Search

Your search keyword '"Lyne R"' showing total 183 results
Start Over Author "Lyne R"
183 results on '"Lyne R"'

1. Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

Author

Luo, X-J, Li, M, Huang, L, Steinberg, S, Mattheisen, M, Liang, G, Donohoe, G, Shi, Y, Chen, C, Yue, W, Alkelai, A, Lerer, B, Li, Z, Yi, Q, Rietschel, M, Cichon, S, Collier, DA, Tosato, S, Suvisaari, J, Rujescu, Dan, Golimbet, V, Silagadze, T, Durmishi, N, Milovancevic, MP, Stefansson, H, Schulze, TG, Nöthen, MM, Lyne, R, Morris, DW, Gill, M, Corvin, A, Zhang, D, Dong, Q, Moyzis, RK, Stefansson, K, Sigurdsson, E, Hu, F, Su, B, and Gan, L

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Serious Mental Illness, Genetics, Brain Disorders, Human Genome, Schizophrenia, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Mental health, Alleles, Asian People, Brain, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Case-Control Studies, Cognition, Databases, Genetic, Down-Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Personality, Polymorphism, Single Nucleotide, Protein Interaction Maps, Schizophrenic Psychology, White People, association, CAMKK2, eQTL, expression, protein-protein interaction, schizophrenia, MooDS SCZ Consortium, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, which examined changes in gene expression in schizophrenia patients and their matched controls. We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies. To seek the potential genetic variants that may regulate the expression of CAMKK2, we investigated the association between single-nucleotide polymorphisms (SNPs) within CAMKK2 and the expression level of CAMKK2. We found one SNP, rs1063843, which is located in intron 17 of CAMKK2, is strongly associated with the expression level of CAMKK2 in human brains (P=1.1 × 10(-6)) and lymphoblastoid cell lines (the lowest P=8.4 × 10(-6)). We further investigated the association between rs1063843 and schizophrenia in multiple independent populations (a total of 130 623 subjects) and found rs1063843 is significantly associated with schizophrenia (P=5.17 × 10(-5)). Interestingly, we found the T allele of rs1063843, which is associated with lower expression level of CAMKK2, has a higher frequency in individuals with schizophrenia in all of the tested samples, suggesting rs1063843 may be a causal variant. We also found that rs1063843 is associated with cognitive function and personality in humans. In addition, protein-protein interaction (PPI) analysis revealed that CAMKK2 participates in a highly interconnected PPI network formed by top schizophrenia genes, which further supports the potential role of CAMKK2 in the pathogenesis of schizophrenia. Taken together, these converging lines of evidence strongly suggest that CAMKK2 may have pivotal roles in schizophrenia susceptibility.

Published
2014

7. Ciris

Author

Lyne, R. O. A. M., primary and Holzberg, Niklas, additional

Published
2015
Full Text
View/download PDF

15. The DNA sequence and biological annotation of human chromosome 1

Author

Gregory, S. G., Barlow, K. F., McLay, K. E., Kaul, R., Swarbreck, D., Dunham, A., Scott, C. E., Howe, K. L., Woodfine, K., Spencer, C. C. A., Jones, M. C., Gillson, C., Searle, S., Zhou, Y., Kokocinski, F., McDonald, L., Evans, R., Phillips, K., Atkinson, A., Cooper, R., Jones, C., Hall, R. E., Andrews, T. D., Lloyd, C., Ainscough, R., Almeida, J. P., Ambrose, K. D., Anderson, F., Andrew, R. W., Ashwell, R. I. S., Aubin, K., Babbage, A. K., Bagguley, C. L., Bailey, J., Beasley, H., Bethel, G., Bird, C. P., Bray-Allen, S., Brown, J. Y., Brown, A. J., Buckley, D., Burton, J., Bye, J., Carder, C., Chapman, J. C., Clark, S. Y., Clarke, G., Clee, C., Cobley, V., Collier, R. E., Corby, N., Coville, G. J., Davies, J., Deadman, R., Dunn, M., Earthrowl, M., Ellington, A. G., Errington, H., Frankish, A., Frankland, J., French, L., Garner, P., Garnett, J., Gay, L., Ghori, M. R. J., Gibson, R., Gilby, L. M., Gillett, W., Glithero, R. J., Grafham, D. V., Griffiths, C., Griffiths-Jones, S., Grocock, R., Hammond, S., Harrison, E. S. I., Hart, E., Haugen, E., Heath, P. D., Holmes, S., Holt, K., Howden, P. J., Hunt, A. R., Hunt, S. E., Hunter, G., Isherwood, J., James, R., Johnson, C., Johnson, D., Joy, A., Kay, M., Kershaw, J. K., Kibukawa, M., Kimberley, A. M., King, A., Knights, A. J., Lad, H., Laird, G., Lawlor, S., Leongamornlert, D. A., Lloyd, D. M., Loveland, J., Lovell, J., Lush, M. J., Lyne, R., Martin, S., Mashreghi-Mohammadi, M., Matthews, L., Matthews, N. S. W., McLaren, S., Milne, S., Mistry, S., Nickerson, T., O'Dell, C. N., Oliver, K., Palmeiri, A., Palmer, S. A., Parker, A., Patel, D., Pearce, A. V., Peck, A. I., Pelan, S., Phelps, K., Phillimore, B. J., Plumb, R., Rajan, J., Raymond, C., Rouse, G., Saenphimmachak, C., Sehra, H. K., Sheridan, E., Shownkeen, R., Sims, S., Skuce, C. D., Smith, M., Steward, C., Subramanian, S., Sycamore, N., Tracey, A., Tromans, A., Van Helmond, Z., Wall, M., Wallis, J. M., White, S., Whitehead, S. L., Wilkinson, J. E., Willey, D. L., Williams, H., Wilming, L., Wray, P. W., Wu, Z., Coulson, A., Vaudin, M., Sulston, J. E., Durbin, R., Hubbard, T., Wooster, R., Dunham, I., Carter, N. P., McVean, G., Ross, M. T., Harrow, J., Olson, M. V., Beck, S., Rogers, J., and Bentley, D. R.

Abstract

Author(s): S. G. Gregory (corresponding author) [1, 2]; K. F. Barlow [1]; K. E. McLay [1]; R. Kaul [3]; D. Swarbreck [1]; A. Dunham [1]; C. E. Scott [1]; K. [...]

Published
2006
Full Text
View/download PDF

16. The genome sequence of Schizosaccharomyces pombe

Author

Wood, V., Gwilliam, R., Rajandream, M.-A., Lyne, M., Lyne, R., Stewart, A., Sgouros, J., Peat, N., Hayles, J., Baker, S., Basham, D., Bowman, S., Brooks, K., Brown, D., Brown, S., Chillingworth, T., Churcher, C., Collins, M., Connor, R., Cronin, A., Davis, P., Feltwell, T., Fraser, A., Gentles, S., Goble, A., Hamlin, N., Harris, D., Hidalgo, J., Hodgson, G., Holroyd, S., Hornsby, T., Howarth, S., Huckle, E. J., Hunt, S., Jagels, K., James, K., Jones, L., Jones, M., Leather, S., McDonald, S., McLean, J., Mooney, P., Moule, S., Mungall, K., Murphy, L., Niblett, D., Odell, C., Oliver, K., O'Neil, S., Pearson, D., Quail, M. A., Rabbinowitsch, E., Rutherford, K., Rutter, S., Saunders, D., Seeger, K., Sharp, S., Skelton, J., Simmonds, M., Squares, R., Squares, S., Stevens, K., Taylor, K., Taylor, R. G., Tivey, A., Walsh, S., Warren, T., Whitehead, S., Woodward, J., Volckaert, G., Aert, R., Robben, J., Grymonprez, B., Weltjens, I., Vanstreels, E., Rieger, M., Schafer, M., Muller-Auer, S., Gabel, C., Fuchs, M., Fritzc, C., Holzer, E., Moestl, D., Hilbert, H., Borzym, K., Langer, I., Beck, A., Lehrach, H., Reinhardt, R., Pohl, T. M., Eger, P., Zimmermann, W., Wedler, H., Wambutt, R., Purnelle, B., Goffeau, A., Cadieu, E., Dreano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Aves, S. J., Xiang, Z., Hunt, C., Moore, K., Hurst, S. M., Lucas, M., Rochet, M., Gaillardin, C., Tallada, V. A., Garzon, A., Thode, G., Daga, R. R., Cruzado, L., Jimenez, J., Sanchez, M., del Rey, F., Benito, J., Dominguez, A., Revuelta, J. L., Moreno, S., Armstrong, J., Forsburg, S. L., Cerrutti, L., Lowe, T., McCombie, W. R., Paulsen, I., Potashkin, J., Shpakovski, G. V., Ussery, D., Barrell, B. G., and Nurse, P.

Abstract

Author(s): V. Wood [1]; R. Gwilliam [1]; M.-A. Rajandream (corresponding author) [1]; M. Lyne [1]; R. Lyne [1]; A. Stewart [2]; J. Sgouros [2]; N. Peat [3]; J. Hayles [3]; [...]

Published
2002
Full Text
View/download PDF

21. The association between perceived cause of glaucoma and illness perceptions

Author

Eunice Choe, Shervonne Poleon, Tracy Thomas, and Lyne Racette

Subjects
primary open-angle glaucoma, POAG, cause of disease, illness perception, BIPQ, Medicine (General), R5-920
Abstract

PurposeThe perceived cause of disease is an important factor that has been linked with treatment outcomes but has not been fully assessed in primary open-angle glaucoma (POAG). This study assessed the accuracy of patients’ perceived cause of POAG and identified associations between accuracy, illness perceptions, medication adherence, and quality of life (QoL).MethodsThe Brief Illness Perception Questionnaire (BIPQ) was used to assess illness perceptions and asked patients to rank the three most important causes of their disease in order of importance. POAG risk factors recognized by the American Academy of Ophthalmology were used to code responses as accurate or inaccurate based on the following three methods: (1) coding any reported cause, regardless of rank, (2) coding only the first-ranked cause, and (3) coding and weighting all reported causes. Medication adherence was measured electronically. QoL was measured using the Glaucoma Quality of Life questionnaire. Mann–Whitney U test was used to detect differences in illness perceptions, medication adherence, and QoL between accuracy groups.ResultsA total of 97 patients identified a cause of their POAG and were included in this analysis. A higher proportion of patients reported an accurate cause (86.6% using method 1, 78.4% using method 2, and 79.4% using method 3; all p 0.05). Using method 2 (p = 0.045) and method 3 (p = 0.028), patients who reported an accurate cause of their POAG believed that their illness would last for a longer time compared to patients who reported an inaccurate cause. Method 3 also revealed that patients who reported an accurate cause of their POAG had lower perceived understanding of their illness (p = 0.048) compared to patients who reported an inaccurate cause. There were no differences in QoL between accuracy groups (all p > 0.05).ConclusionThis study highlights the association between perceived cause of POAG and illness perceptions related to knowledge level and POAG duration. Future studies should assess associations between perceived cause of disease and other critical dimensions of illness perception.

Published
2024
Full Text
View/download PDF

23. The genome sequence of Schizosaccharomyces pombe (vol 415, pg 871, 2002)

Author

Wood, V, Gwilliam, R, Rajandream, M, Lyne, M, Lyne, R, Stewart, A, Sgouros, J, Peat, N, Hayles, J, Baker, S, Basham, D, Bowman, S, Brooks, K, Brown, D, Brown, S, Chillingworth, T, Churcher, C, Collins, M, Connor, R, Cronin, A, Davis, P, Feltwell, T, Fraser, A, Gentles, S, and Goble, A

Published
2016

24. Notes de lecture

Author

Lyne, R. O. A. M., Hunt, J. M., Guilbert, D., and Stégen, Guillaume

Published
1969

30. Making linked data SPARQL with the InterMine biological data warehouse

Author

Déraspe, M., Binkley, G., Butano, D., Chadwick, M., Cherry, J.M., Clark-Casey, J., Contrino, S., Corbeil, Jacques, Heimbach, J., Karra, K., Lyne, R., Sullivan, J., Yehudi, Y., Micklem, G., Dumontier, M., Déraspe, M., Binkley, G., Butano, D., Chadwick, M., Cherry, J.M., Clark-Casey, J., Contrino, S., Corbeil, Jacques, Heimbach, J., Karra, K., Lyne, R., Sullivan, J., Yehudi, Y., Micklem, G., and Dumontier, M.

Abstract

InterMine is a system for integrating, analysing, and republishing biological data from multiple sources. It provides access to these data via a web user interface and programmatic web services. However, the precise invocation of services and subsequent exploration of returned data require substantial expertise on the structure of the underlying database. Here, we describe an approach that uses Semantic Web technologies to make InterMine data more broadly accessible and reusable, in accordance with the FAIR principles. We describe a pipeline to extract, transform, and load a Linked Data representation of the InterMine store. We use Docker to bring together SPARQL-aware applications to search, browse, explore, and query the InterMine-based data. Our work therefore extends interoperability of the InterMine platform, and supports new query functionality across InterMine installations and the network of open Linked Data.

Published
2016

31. The DNA sequence of the human X chromosome

Author

ROSS MT, GRAFHAM DV, COFFEY AJ, SCHERER S, MCLAY K, MUZNY D, PLATZER M, HOWELL GR, BURROWS C, BIRD CP, FRANKISH A, LOVELL FL, HOWE KL, ASHURST JL, FULTON RS, SUDBRAK R, WEN G, JONES MC, HURLES ME, ANDREWS TD, SCOTT CE, SEARLE S, RAMSER J, WHITTAKER A, DEADMAN R, CARTER NP, HUNT SE, CHEN R, CREE A, GUNARATNE P, HAVLAK P, HODGSON A, METZKER ML, RICHARDS S, SCOTT G, STEFFEN D, SODERGREN E, WHEELER DA, WORLEY KC, AINSCOUGH R, AMBROSE KD, ANSARI LARI MA, ARADHYA S, ASHWELL RI, BABBAGE AK, BAGGULEY CL, BANERJEE R, BARKER GE, BARLOW KF, BARRETT IP, BATES KN, BEARE DM, BEASLEY H, BEASLEY O, BECK A, BETHEL G, BLECHSCHMIDT K, BRADY N, BRAY ALLEN S, BRIDGEMAN AM, BROWN AJ, BROWN MJ, BONNIN D, BRUFORD EA, BUHAY C, BURCH P, BURFORD D, BURGESS J, BURRILL W, BURTON J, BYE JM, CARDER C, CARREL L, CHAKO J, CHAPMAN JC, CHAVEZ D, CHEN E, CH EN G, CHEN Y, CHEN Z, CHINAULT C, CICCODICOLA A, CLARK SY, CLARKE G, CLEE CM, CLEGG S, CLERC BLANKENBURG K, CLIFFORD K, COBLEY V, COLE CG, CONQUER JS, CORBY N, CONNOR RE, DAVID R, DAVIES J, DAVIS C, DAVIS J, DELGADO O, DESHAZO D, DHAMI P, DING Y, DINH H, DODSWORTH S, DRAPER H, DUGAN ROCHA S, DUNHAM A, DUNN M, DURBIN KJ, DUTTA I, EADES T, ELLWOOD M, EMERY COHEN A, ERRINGTON H, EVANS KL, FAULKNER L, FRANCIS F, FRANKLAND J, FRASER AE, GALGOCZY P, GILBERT J, GILL R, GLOCKNER G, GREGORY SG, GRIBBLE S, GRIFFITHS C, GROCOCK R, GU Y, GWILLIAM R, HAMILTON C, HART EA, HAWES A, HEATH PD, HEITMANN K, HENNIG S, HERNANDEZ J, HINZMANN B, HO S, HOFFS M, HOWDEN PJ, HUCKLE EJ, HUME J, HUNT PJ, HUNT AR, ISHERWOOD J, JACOB L, JOHNSON D, JONES S, DE JONG PJ, JOSEPH SS, KEENAN S, KELLY S, KERSHAW JK, KHAN Z, KIOSCHIS P, KLAGES S, KNIGHTS AJ, KOSIURA A, KOVAR SMITH C, LAIRD GK, LANGFORD C, LAWLOR S, LEVERSHA M, LEWIS L, LIU W, LLOYD C, LLOYD DM, LOULSEGED H, LOVELAND JE, LOVELL JD, LOZADO R, LU J, LYNE R, MA J, MAHESHWARI M, MATTHEWS LH, MCDOWALL J, MCLAREN S, MCMURRAY A, MEIDL P, MEITINGER T, MILNE S, MINER G, MISTRY SL, MORGAN M, MORRIS S, MULLER I, M.U.L.L.I.K.I.N. . ., BALLABIO, ANDREA, Ross, Mt, Grafham, Dv, Coffey, Aj, Scherer, S, Mclay, K, Muzny, D, Platzer, M, Howell, Gr, Burrows, C, Bird, Cp, Frankish, A, Lovell, Fl, Howe, Kl, Ashurst, Jl, Fulton, R, Sudbrak, R, Wen, G, Jones, Mc, Hurles, Me, Andrews, Td, Scott, Ce, Searle, S, Ramser, J, Whittaker, A, Deadman, R, Carter, Np, Hunt, Se, Chen, R, Cree, A, Gunaratne, P, Havlak, P, Hodgson, A, Metzker, Ml, Richards, S, Scott, G, Steffen, D, Sodergren, E, Wheeler, Da, Worley, Kc, Ainscough, R, Ambrose, Kd, ANSARI LARI, Ma, Aradhya, S, Ashwell, Ri, Babbage, Ak, Bagguley, Cl, Ballabio, Andrea, Banerjee, R, Barker, Ge, Barlow, Kf, Barrett, Ip, Bates, Kn, Beare, Dm, Beasley, H, Beasley, O, Beck, A, Bethel, G, Blechschmidt, K, Brady, N, BRAY ALLEN, S, Bridgeman, Am, Brown, Aj, Brown, Mj, Bonnin, D, Bruford, Ea, Buhay, C, Burch, P, Burford, D, Burgess, J, Burrill, W, Burton, J, Bye, Jm, Carder, C, Carrel, L, Chako, J, Chapman, Jc, Chavez, D, Chen, E, CH EN, G, Chen, Y, Chen, Z, Chinault, C, Ciccodicola, A, Clark, Sy, Clarke, G, Clee, Cm, Clegg, S, CLERC BLANKENBURG, K, Clifford, K, Cobley, V, Cole, Cg, Conquer, J, Corby, N, Connor, Re, David, R, Davies, J, Davis, C, Davis, J, Delgado, O, Deshazo, D, Dhami, P, Ding, Y, Dinh, H, Dodsworth, S, Draper, H, DUGAN ROCHA, S, Dunham, A, Dunn, M, Durbin, Kj, Dutta, I, Eades, T, Ellwood, M, EMERY COHEN, A, Errington, H, Evans, Kl, Faulkner, L, Francis, F, Frankland, J, Fraser, Ae, Galgoczy, P, Gilbert, J, Gill, R, Glockner, G, Gregory, Sg, Gribble, S, Griffiths, C, Grocock, R, Gu, Y, Gwilliam, R, Hamilton, C, Hart, Ea, Hawes, A, Heath, Pd, Heitmann, K, Hennig, S, Hernandez, J, Hinzmann, B, Ho, S, Hoffs, M, Howden, Pj, Huckle, Ej, Hume, J, Hunt, Pj, Hunt, Ar, Isherwood, J, Jacob, L, Johnson, D, Jones, S, DE JONG, Pj, Joseph, S, Keenan, S, Kelly, S, Kershaw, Jk, Khan, Z, Kioschis, P, Klages, S, Knights, Aj, Kosiura, A, KOVAR SMITH, C, Laird, Gk, Langford, C, Lawlor, S, Leversha, M, Lewis, L, Liu, W, Lloyd, C, Lloyd, Dm, Loulseged, H, Loveland, Je, Lovell, Jd, Lozado, R, Lu, J, Lyne, R, Ma, J, Maheshwari, M, Matthews, Lh, Mcdowall, J, Mclaren, S, Mcmurray, A, Meidl, P, Meitinger, T, Milne, S, Miner, G, Mistry, Sl, Morgan, M, Morris, S, Muller, I, and M. U. L. L. I. K. I. N. ., .

Published
2005

32. Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

Author

Luo, XJ, Li, M, Huang, L, Steinberg, S, Mattheisen, M, Liang, G, Donohoe, G, Shi, Y, Chen, C, Yue, W, Alkelai, A, Lerer, B, Li, Z, Yi, Q, Rietschel, M, Cichon, S, Collier, DA, Tosato, S, Suvisaari, J, Rujescu, D, Golimbet, V, Silagadze, T, Durmishi, N, Milovancevic, MP, Stefansson, H, Schulze, TG, Nöthen, MM, Lyne, R, Morris, DW, Gill, M, Corvin, A, Zhang, D, Dong, Q, Moyzis, RK, Stefansson, K, Sigurdsson, E, Hu, F, SCZ Consortium36, Su, B, Gan, L, and College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China [2] Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, NY, USA. 2Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA. 31] Nanchang University, Nanchang, China [2] Gannan Medical University, Ganzhou, China [3] Jiangxi Provincial People's Hospital, Nanchang, China. 4deCODE Genetics, Reykjavik, Iceland. 5Department of Biomedicine, Aarhus University, Aarhus C, Denmark. 6College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. 7Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland. 8Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. 9Department of Psychology and Social Behavior, University of California, Irvine, CA, USA. 101] Institute of Mental Health, Peking University, Beijing, China [2] Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. 11Department of Psychiatry, Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 12Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi, China. 13Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, Mannheim, Germany. 14Department of Genomics, Life and Brain Center, and Institute of Human Genetics, University of Bonn, Bonn, Germany. 151] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Eli Lilly and Co. Ltd, Erl Wood Manor, Surrey, UK. 16Section of Psychiatry, University of Verona, Verona, Italy. 17Mental Health and Substance Abuse Services, National Institute for Health and Welfare THL, Helsinki, Finland. 181] Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany [2] Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany. 19Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia. 20Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia. 21Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia. 22Medical Faculty, University of Belgrade, Belgrade, Serbia. 23Department of Psychiatry and Psychotherapy, University Medical Center Georg-August-Universität, Goettingen, Germany. 24State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. 25Department of Biological Chemistry, University of California, Irvine, CA, USA. 261] deCODE Genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland. 271] School of Medicine, University of Iceland, Reykjavik, Iceland [2] Department of Psychiatry, National University Hospital, Reykjavik, Iceland. 28Affiliated Eye Hospital of Nanchang University, Nanchang, China. 29State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Subjects
Pathogenesis, protein-protein interaction, 0302 clinical medicine, Cognition, Gene expression, Genamengi, Databases, Genetic, Protein Interaction Maps, European Continental Ancestry Group/genetics, Psychotic Disorders/genetics, CAMKK2, Schizophrenic Psychology, Genetics, 0303 health sciences, Brain, Chromosome Mapping, Polymorphism, Single Nucleotide/genetics, Psychiatry and Mental health, Geðsjúkdómar, Personality, Genotype, Schizophrenia (object-oriented programming), Down-Regulation, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Single-nucleotide polymorphism, Calcium-Calmodulin-Dependent Protein Kinase, Biology, eQTL, Polymorphism, Single Nucleotide, White People, 03 medical and health sciences, Cellular and Molecular Neuroscience, Asian People, Geðklofi, Personality/genetics, Kinase/metabolism, expression, SNP, Brain/metabolism, Humans, Genetic Predisposition to Disease, Asian Continental Ancestry Group/genetics, Allele, Molecular Biology, Gene, association, schizophrenia, Alleles, 030304 developmental biology, Arfgengi, Kinase/genetics, Schizophrenia/genetics, Case-Control Studies, Protein Interaction Maps/genetics, 030217 neurology & neurosurgery, Chromosomes, Human, Pair 17, Genome-Wide Association Study
Abstract

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, which examined changes in gene expression in schizophrenia patients and their matched controls. We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies. To seek the potential genetic variants that may regulate the expression of CAMKK2, we investigated the association between single-nucleotide polymorphisms (SNPs) within CAMKK2 and the expression level of CAMKK2. We found one SNP, rs1063843, which is located in intron 17 of CAMKK2, is strongly associated with the expression level of CAMKK2 in human brains (P=1.1 × 10(-6)) and lymphoblastoid cell lines (the lowest P=8.4 × 10(-6)). We further investigated the association between rs1063843 and schizophrenia in multiple independent populations (a total of 130 623 subjects) and found rs1063843 is significantly associated with schizophrenia (P=5.17 × 10(-5)). Interestingly, we found the T allele of rs1063843, which is associated with lower expression level of CAMKK2, has a higher frequency in individuals with schizophrenia in all of the tested samples, suggesting rs1063843 may be a causal variant. We also found that rs1063843 is associated with cognitive function and personality in humans. In addition, protein-protein interaction (PPI) analysis revealed that CAMKK2 participates in a highly interconnected PPI network formed by top schizophrenia genes, which further supports the potential role of CAMKK2 in the pathogenesis of schizophrenia. Taken together, these converging lines of evidence strongly suggest that CAMKK2 may have pivotal roles in schizophrenia susceptibility. National Natural Science Foundation of China/81271006/ 81060081 Hangzhou City Health Science Foundation/20120633B01 Jiangxi Provincial Natural Science Foundation/2010GZY0089/20114BAB215006 Natural Science Foundation of China/U1202225/81130022/ 81272302/31000553 863 Program 2012AA02A515 EU/HEALTH-2011-286213 HEALTH-F2-2009-223423 111 Project of the Ministry of Education of China/B07008 Israel Science Foundation info:eu-repo/grantAgreement/EC/FP7/286213

Published
2014
Full Text
View/download PDF

34. The genome sequence of Schizosaccharomyces pombe (vol 415, pg 871, 2002)

Author

Wood, V, Gwilliam, R, Rajandream, MA, Lyne, M, Lyne, R, Stewart, A, Sgouros, J, Peat, N, Hayles, J, Baker, S, Basham, D, Bowman, S, Brooks, K, Brown, D, Brown, S, Chillingworth, T, Churcher, C, Collins, M, Connor, R, Cronin, A, Davis, P, Feltwell, T, Fraser, A, Gentles, S, Goble, A, Hamlin, N, Harris, D, Hidalgo, J, Hodgson, G, Holroyd, S, Hornsby, T, Howarth, S, Huckle, EJ, Hunt, S, Jagels, K, James, K, Jones, L, Jones, M, Leather, S, McDonald, S, McLean, J, Mooney, P, Moule, S, Mungall, K, Murphy, L, Niblett, D, Odell, C, Oliver, K, O'Neil, S, Pearson, D, Quail, MA, Rabbinowitsch, E, Rutherford, K, Rutter, S, Saunders, D, Seeger, K, Sharp, S, Skelton, J, Simmonds, M, Squares, R, Squares, S, Stevens, K, Taylor, K, Taylor, RG, Tivey, A, Walsh, S, Warren, T, Whitehead, S, Woodward, J, Volckaert, G, Aert, R, Robben, J, Grymonprez, B, Weltjens, I, Vanstreels, E, Rieger, M, Schafer, M, Muller-Auer, S, Gabel, C, Fuchs, M, Dusterhoft, A, Fritzc, C, Holzer, E, Moestl, D, Hilbert, H, Borzym, K, Langer, I, Beck, A, Lehrach, H, Reinhardt, R, Pohl, TM, Eger, P, Zimmermann, W, Wedler, H, Wambutt, R, Purnelle, B, Goffeau, A, Cadieu, E, Dreano, S, Gloux, S, Lelaure, V, Mottier, S, Galibert, F, Aves, SJ, Xiang, Z, Hunt, C, Moore, K, Hurst, SM, Lucas, M, Rochet, M, Gaillardin, C, Tallada, VA, Garzon, A, Thode, G, Daga, RR, Cruzado, L, Jimenez, J, Sanchez, M, del Rey, F, Benito, J, Dominguez, A, Revuelta, JL, Moreno, S, Armstrong, J, Forsburg, SL, Cerutti, L, Lowe, T, McCombie, WR, Paulsen, I, Potashkin, J, Shpakovski, GV, Ussery, D, Barrell, BG, and Nurse, P

Published
2003

35. Whitecoat Adherence in Patients With Primary Open-Angle Glaucoma

Author

Shervonne Poleon, Nouran Sabbagh, and Lyne Racette

Subjects
glaucoma, medication, whitecoat, adherence, implementation phase, Medicine (General), R5-920
Abstract

PurposeWhitecoat adherence refers to improved medication adherence in the days surrounding clinic visits. This may lead to clinical measures that are not representative of those outside of clinical encounters. In glaucoma, whitecoat adherence to prescribed hypotensive therapy may lead to intraocular pressure readings within the target range, which may impact clinical decision-making. We aimed to quantify and identify factors associated with whitecoat adherence.MethodsIn this cohort study, patients with primary open-angle glaucoma were selected from an ongoing longitudinal NIH-funded study if they used hypotensive eyedrops, had a clinic visit during the parent study, and had adherence data during the 28 days evenly bracketing the clinic visit. Adherence within the implementation phase was measured using Medication Event Monitoring System (MEMS) caps. Wilcoxon tests were used to compare mean adherence between the following periods: Pre14−4 (days 14 to 4 preceding the clinic visit) and Pre3−1 (days 3 to 1 preceding the visit); Post1−3 (days 1 to 3 following the clinic visit) and Post4−14 (days 4 to 14 following the visit). Analyses were performed in the full sample and in patients with optimal (≥80%, n = 49) and suboptimal adherence (

Published
2022
Full Text
View/download PDF

37. modMine: flexible access to modENCODE data

Author

Contrino, S., primary, Smith, R. N., additional, Butano, D., additional, Carr, A., additional, Hu, F., additional, Lyne, R., additional, Rutherford, K., additional, Kalderimis, A., additional, Sullivan, J., additional, Carbon, S., additional, Kephart, E. T., additional, Lloyd, P., additional, Stinson, E. O., additional, Washington, N. L., additional, Perry, M. D., additional, Ruzanov, P., additional, Zha, Z., additional, Lewis, S. E., additional, Stein, L. D., additional, and Micklem, G., additional

Published
2011
Full Text
View/download PDF

41. Erratum: The DNA sequence and biological annotation of human chromosome 1

Author

Gregory, S. G., primary, Barlow, K. F., additional, McLay, K. E., additional, Kaul, R., additional, Swarbreck, D., additional, Dunham, A., additional, Scott, C. E., additional, Howe, K. L., additional, Woodfine, K., additional, Spencer, C. C. A., additional, Jones, M. C., additional, Gillson, C., additional, Searle, S., additional, Zhou, Y., additional, Kokocinski, F., additional, McDonald, L., additional, Evans, R., additional, Phillips, K., additional, Atkinson, A., additional, Cooper, R., additional, Jones, C., additional, Hall, R. E., additional, Andrews, T. D., additional, Lloyd, C., additional, Ainscough, R., additional, Almeida, J. P., additional, Ambrose, K. D., additional, Anderson, F., additional, Andrew, R. W., additional, Ashwell, R. I. S., additional, Aubin, K., additional, Babbage, A. K., additional, Bagguley, C. L., additional, Bailey, J., additional, Banerjee, R., additional, Beasley, H., additional, Bethel, G., additional, Bird, C. P., additional, Bray-Allen, S., additional, Brown, J. Y., additional, Brown, A. J., additional, Bryant, S. P., additional, Buckley, D., additional, Burford, D. C., additional, Burrill, W. D. H., additional, Burton, J., additional, Bye, J., additional, Carder, C., additional, Chapman, J. C., additional, Clark, S. Y., additional, Clarke, G., additional, Clee, C., additional, Clegg, S. M., additional, Cobley, V., additional, Collier, R. E., additional, Corby, N., additional, Coville, G. J., additional, Davies, J., additional, Deadman, R., additional, Dhami, P., additional, Dovey, O., additional, Dunn, M., additional, Earthrowl, M., additional, Ellington, A. G., additional, Errington, H., additional, Faulkner, L. M., additional, Frankish, A., additional, Frankland, J., additional, French, L., additional, Garner, P., additional, Garnett, J., additional, Gay, L., additional, Ghori, M. R. J., additional, Gibson, R., additional, Gilby, L. M., additional, Gillett, W., additional, Glithero, R. J., additional, Grafham, D. V., additional, Gribble, S. M., additional, Griffiths, C., additional, Griffiths-Jones, S., additional, Grocock, R., additional, Hammond, S., additional, Harrison, E. S. I., additional, Hart, E., additional, Haugen, E., additional, Heath, P. D., additional, Holmes, S., additional, Holt, K., additional, Howden, P. J., additional, Hunt, A. R., additional, Hunt, S. E., additional, Hunter, G., additional, Isherwood, J., additional, James, R., additional, Johnson, C., additional, Johnson, D., additional, Joy, A., additional, Kay, M., additional, Kershaw, J. K., additional, Kibukawa, M., additional, Kimberley, A. M., additional, King, A., additional, Knights, A. J., additional, Lad, H., additional, Laird, G., additional, Langford, C. F., additional, Lawlor, S., additional, Leongamornlert, D. A., additional, Lloyd, D. M., additional, Loveland, J., additional, Lovell, J., additional, Lush, M. J., additional, Lyne, R., additional, Martin, S., additional, Mashreghi-Mohammadi, M., additional, Matthews, L., additional, Matthews, N. S. W., additional, McLaren, S., additional, Milne, S., additional, Mistry, S., additional, oore, M. J. F. M., additional, Nickerson, T., additional, O'Dell, C. N., additional, Oliver, K., additional, Palmeiri, A., additional, Palmer, S. A., additional, Pandian, R. D., additional, Parker, A., additional, Patel, D., additional, Pearce, A. V., additional, Peck, A. I., additional, Pelan, S., additional, Phelps, K., additional, Phillimore, B. J., additional, Plumb, R., additional, Porter, K. M., additional, Prigmore, E., additional, Rajan, J., additional, Raymond, C., additional, Rouse, G., additional, Saenphimmachak, C., additional, Sehra, H. K., additional, Sheridan, E., additional, Shownkeen, R., additional, Sims, S., additional, Skuce, C. D., additional, Smith, M., additional, Steward, C., additional, Subramanian, S., additional, Sycamore, N., additional, Tracey, A., additional, Tromans, A., additional, Van Helmond, Z., additional, Wall J. M. Wallis, M., additional, White, S., additional, Whitehead, S. L., additional, Wilkinson, J. E., additional, Willey, D. L., additional, Williams, H., additional, Wilming, L., additional, Wray, P. W., additional, Wu, Z., additional, Coulson, A., additional, Vaudin, M., additional, Sulston, J. E., additional, Durbin, R., additional, Hubbard, T., additional, Wooster, R., additional, Dunham, I., additional, Carter, N. P., additional, McVean, G., additional, Ross, M. T., additional, Harrow, J., additional, Olson, M. V., additional, Beck, S., additional, Rogers, J., additional, and Bentley, D. R., additional

Published
2006
Full Text
View/download PDF

45. corrigendum: The genome sequence of Schizosaccharomyces pombe

Author

Wood, V., Gwilliam, R., Rajandream, M.-A., Lyne, M., Lyne, R., Stewart, A., Sgouros, J., Peat, N., Hayles, J., Baker, S., Basham, D., Bowman, S., Brooks, K., Brown, D., Brown, S., Chillingworth, T., Churcher, C., Collins, M., Connor, R., Cronin, A., Davis, P., Feltwell, T., Fraser, A., Gentles, S., Goble, A., Hamlin, N., Harris, D., Hidalgo, J., Hodgson, G., Holroyd, S., Hornsby, T., Howarth, S., Huckle, E. J., Hunt, S., Jagels, K., James, K., Jones, L., Jones, M., Leather, S., McDonald, S., McLean, J., Mooney, P., Moule, S., Mungall, K., Murphy, L., Niblett, D., Odell, C., Oliver, K., O'Neil, S., Pearson, D., Quail, M. A., Rabbinowitsch, E., Rutherford, K., Rutter, S., Saunders, D., Seeger, K., Sharp, S., Skelton, J., Simmonds, M., Squares, R., Squares, S., Stevens, K., Taylor, K., Taylor, R. G., Tivey, A., Walsh, S., Warren, T., Whitehead, S., Woodward, J., Volckaert, G., Aert, R., Robben, J., Grymonprez, B., Weltjens, I., Vanstreels, E., Rieger, M., Schafer, M., Muller-Auer, S., Gabel, C., Fuchs, M., Dusterhoft, A., Fritzc, C., Holzer, E., Moestl, D., Hilbert, H., Borzym, K., Langer, I., Beck, A., Lehrach, H., Reinhardt, R., Pohl, T. M., Eger, P., Zimmermann, W., Wedler, H., Wambutt, R., Purnelle, B., Goffeau, A., Cadieu, E., Dreano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Aves, S. J., Xiang, Z., Hunt, C., Moore, K., Hurst, S. M., Lucas, M., Rochet, M., Gaillardin, C., Tallada, V. A., Garzon, A., Thode, G., Daga, R. R., Cruzado, L., Jimenez, J., Sanchez, M., del Rey, F., Benito, J., Dominguez, A., Revuelta, J. L., Moreno, S., Armstrong, J., Forsburg, S. L., Cerutti, L., Lowe, T., McCombie, W. R., Paulsen, I., Potashkin, J., Shpakovski, G. V., Ussery, D., Barrell, B. G., and Nurse, P.

Abstract

Author(s): V. Wood; R. Gwilliam; M.-A. Rajandream; M. Lyne; R. Lyne; A. Stewart; J. Sgouros; N. Peat; J. Hayles; S. Baker; D. Basham; S. Bowman; K. Brooks; D. Brown; S. [...]

Published
2003
Full Text
View/download PDF

46. Erratum: corrigendum: The genome sequence of Schizosaccharomyces pombe

Author

Wood, V., primary, Gwilliam, R., additional, Rajandream, M.-A., additional, Lyne, M., additional, Lyne, R., additional, Stewart, A., additional, Sgouros, J., additional, Peat, N., additional, Hayles, J., additional, Baker, S., additional, Basham, D., additional, Bowman, S., additional, Brooks, K., additional, Brown, D., additional, Brown, S., additional, Chillingworth, T., additional, Churcher, C., additional, Collins, M., additional, Connor, R., additional, Cronin, A., additional, Davis, P., additional, Feltwell, T., additional, Fraser, A., additional, Gentles, S., additional, Goble, A., additional, Hamlin, N., additional, Harris, D., additional, Hidalgo, J., additional, Hodgson, G., additional, Holroyd, S., additional, Hornsby, T., additional, Howarth, S., additional, Huckle, E. J., additional, Hunt, S., additional, Jagels, K., additional, James, K., additional, Jones, L., additional, Jones, M., additional, Leather, S., additional, McDonald, S., additional, McLean, J., additional, Mooney, P., additional, Moule, S., additional, Mungall, K., additional, Murphy, L., additional, Niblett, D., additional, Odell, C., additional, Oliver, K., additional, O'Neil, S., additional, Pearson, D., additional, Quail, M. A., additional, Rabbinowitsch, E., additional, Rutherford, K., additional, Rutter, S., additional, Saunders, D., additional, Seeger, K., additional, Sharp, S., additional, Skelton, J., additional, Simmonds, M., additional, Squares, R., additional, Squares, S., additional, Stevens, K., additional, Taylor, K., additional, Taylor, R. G., additional, Tivey, A., additional, Walsh, S., additional, Warren, T., additional, Whitehead, S., additional, Woodward, J., additional, Volckaert, G., additional, Aert, R., additional, Robben, J., additional, Grymonprez, B., additional, Weltjens, I., additional, Vanstreels, E., additional, Rieger, M., additional, Schäfer, M., additional, Müller-Auer, S., additional, Gabel, C., additional, Fuchs, M., additional, Düsterhöft, A., additional, Fritzc, C., additional, Holzer, E., additional, Moestl, D., additional, Hilbert, H., additional, Borzym, K., additional, Langer, I., additional, Beck, A., additional, Lehrach, H., additional, Reinhardt, R., additional, Pohl, T. M., additional, Eger, P., additional, Zimmermann, W., additional, Wedler, H., additional, Wambutt, R., additional, Purnelle, B., additional, Goffeau, A., additional, Cadieu, E., additional, Dréano, S., additional, Gloux, S., additional, Lelaure, V., additional, Mottier, S., additional, Galibert, F., additional, Aves, S. J., additional, Xiang, Z., additional, Hunt, C., additional, Moore, K., additional, Hurst, S. M., additional, Lucas, M., additional, Rochet, M., additional, Gaillardin, C., additional, Tallada, V. A., additional, Garzon, A., additional, Thode, G., additional, Daga, R. R., additional, Cruzado, L., additional, Jimenez, J., additional, Sánchez, M., additional, del Rey, F., additional, Benito, J., additional, Domínguez, A., additional, Revuelta, J. L., additional, Moreno, S., additional, Armstrong, J., additional, Forsburg, S. L., additional, Cerutti, L., additional, Lowe, T., additional, McCombie, W. R., additional, Paulsen, I., additional, Potashkin, J., additional, Shpakovski, G. V., additional, Ussery, D., additional, Barrell, B. G., additional, and Nurse, P., additional

Published
2003
Full Text
View/download PDF

47. Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma.

Author

Fang-I Chu and Lyne Racette

Subjects
Medicine, Science
Abstract

PurposeTo characterize and quantify the temporal relationship between structural and functional change in glaucoma.Methods120 eyes of 120 patients with ocular hypertension or primary open-angle glaucoma were selected from the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study. Patients had 11 visits, separated by at least 3 months over 5 to 10 years. Each visit had rim area (RA) and mean sensitivity (MS) measurements taken within a 30-day period. The structure-function (SF) relationship was summarized using conventional and modified cross-correlation functions (CCFs), which identified the strongest absolute and positive correlation, respectively. Patients were categorized in one of the following three groups: RA and MS evolved simultaneously (lag = 0), RA preceded MS (lag0). Lagging regression analysis was used to examine the variations of the SF relationship within groups.ResultsThe number of participants, mean visit lag, and mean correlation (standard deviation) were, for the conventional and modified CCFs, respectively: lag = 0 [16, 0, 0.53 (0.10) and 16, 0, 0.46 (0.11)]; lag0 [54, 3.35, 0.53 (0.13) and 49, 3.78, 0.45 (0.12)]. A significant difference of the visit lag relation within groups was identified using lagging regression analysis (pConclusionsThe strongest relationship between structure and function was obtained at different visit lags in different patients. This finding also suggests that the SF relationship should be addressed at the subject level when using both measurements jointly to model glaucoma progression.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results