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The present study tested for gender differences in depressive symptoms in a sample of 622 low-income, urban, African American adolescents. Results indicate that adolescent girls in this sample were significantly more likely to endorse depressive symptoms than were boys. To examine possible explanations for this gender difference, 2 variables were tested as mediators of the relation between gender and depressive symptoms: (1) interpersonal stressors and (2) ruminative coping. Results indicate that ruminative coping, but not interpersonal stressors, mediated the relation between gender and depressive symptoms in this sample. Possible explanations for these findings, in light of the common and unique experiences of low-income, urban youth of color, are explored.