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Infectious agents were detected in 100% of examined children with Reiter's disease (RD). Chlamydia trachomatis were detected in 98% of cases. In children with RD lesions of joints and eyes often took acute forms with cases of sacroiliitis, early muscular atrophy and conjunctivitis. In 95% of the patients the prostatitis manifestations were detected. In children with RD a rised number of CD lymphocytes in combination with the fivefold rised IL-4 content, an essential increase in the activity of C2-C5 components of the complement and a multiple rised level of PSA were registered.

We demonstrate that a size-dependent mesoscopic mismatch exists in homoepitaxy, which has a strong impact on the morphology of the islands and the substrate. Atomic scale calculations for double layer Cu islands on Cu(111) reveal that mesoscopic strain relaxations in both islands and the substrate strongly influence the shape of islands and can effect the details of atomic motion near the island.

Reiter's disease in children was shown to be not such a rare disorder and to occur as the polysystemic process. The inflammation is induced by trigger agent (mostly by Chlamydia trachomatis), but then afterwards the key role has inadequate activation of cell-mediated and humoral immunity that may be manifested by substantial enhancement of leuko- and lymphopoiesis. There is an elevation of total number of leukocytes, T cells and lymphocytes, expressing CD4, CD8 and CD25 receptors with sharp increase of CD4/CD8 ratio. The numbers of natural killer cells (CD16) and cells, expressing activation markers, are 2 times higher than in healthy children. Besides, levels of IL-4 and IFN-gamma were increased in great numbers. Severity and duration of the disease course are genetically predetermined. Children - carriers of HLA B27 antigen - had 10-fold elevation of CD71 cells and IFN-gamma in comparison with control group and patients with Reiter's disease, but without this antigen.

Two cases of diagnostic mistakes of Reuter's disease in for children have been described. 7-year-old girl has been operated on for the suspicion on hematogenic osteomyelitis. The diagnosis was not confirmed. The symptoms of Reuter disease-right knee and hip joints synovitis-have appeared in postoperative period. A nonsignificant trauma in 9-year-old boy was the reason for the diagnosis of nontraumatic arthritis. Despite of Reuter's disease symptoms (arthritis, urethritis and conjunctivitis) the immobilization of extremities has been done. In 7 of 30 patients the Reuter's disease has not been diagnosed from the beginning.

Nucleotide metabolism (pools A, G, C, U, xanthine, uric acid) in lymph nodes of two groups of white rats (the 1st model, the 2nd model) has been studied under the influence of hypoxic hypoxia (HH) with further comparative estimation of the findings. The 1st model of HH corresponded to 12 thou. m (up to the death of animals at that "height"). The nucleotide metabolism status in lymph nodes is characterized by irreversible disturbances of the nucleotide component levels and correlations. Significant tension of the nucleotide metabolism causes decompensation of the substrate-enzymatic regulation of metabolism in the lymphoid tissue. The 2nd model of HH corresponded also to 12 thou. m (up to the survival of animals at that "height"). Reversible indices of nucleotide metabolism in lymph nodes of rats are marked (deviations of the majority of indices are not so deep as in the 1st model). The reversible character of changes in the nucleotide metabolism testifies to conservation of the substrate-enzymatic self-regulation in the lymphoid tissue.

The author discusses the risk factors that may be conducive to the development of postgonorrheal diseases in women. When only opportunistic microflora can be isolated from urogenital discharge, postgonorrheal diseases may develop in patients with a poor local immunity. Before gonorrhea treatment the cervical mucus lysozyme activity has been reduced 10-fold in these women, and the level of secretory IgA has been but 7.33% of the normal value.