487 results on '"M, Baquero"'
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2. 21698. MENINGITIS TUBERCULOSA EN EL ANTIGUO HOSPITAL DEL REY DE MADRID: SERIE DE CASOS CON ESTUDIO DE NECROPSIA
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L. Lacruz Ballester, C. Bojo Canales, M. Meseguer, and M. Baquero
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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3. 20336. DIAGNÓSTICO Y PRONÓSTICO EN LA ENFERMEDAD DE ALZHEIMER: COHORTE VALCODIS (2017-2023)
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L. Álvarez Sánchez, M. Baquero Toledo, L. Ferré González, I. Ferrer Cairols, L. García Vallés, M. Peretó Pamblanco, L. Raga Rodríguez, C. Peña Bautista, G. García Lluch, B. Muria Romero, A. Prieto Cagigal, I. Jareño Toboso, and C. Cháfer Pericás
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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4. 21087. ANÁLISIS PROTEÓMICO EN PLASMA PARA LA IDENTIFICACIÓN DE RUTAS BIOQUÍMICAS Y BIOMARCADORES TEMPRANOS EN LA ENFERMEDAD DE ALZHEIMER
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C. Cháfer Pericás, C. Peña Bautista, L. Álvarez Sánchez, A. Balaguer Timor, L. Ferré González, M. Peretó Pamblanco, and M. Baquero Toledo
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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5. Guía mexicana de práctica clínica para el diagnóstico y el tratamiento de la insuficiencia cardiaca
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Abel A. Pavía-López, José A. Magaña-Serrano, José A. Cigarroa-López, Adolfo Chávez-Mendoza, José L. Mayorga-Butrón, Diego Araiza-Garaygordobil, Juan B. Ivey-Miranda, Gustavo F. Méndez-Machado, Héctor González-Godínez, Luisa F. Aguilera-Mora, Antonio Jordán-Ríos, Luis Olmos-Domínguez, Marcos J. Olalde-Román, Emma M. Miranda-Malpica, Zuilma Vásquez-Ortiz, Jorge Rayo-Chávez, Alexandra Arias-Mendoza, Manlio F. Márquez-Murillo, Sergio A. Chávez-Leal, Amada Álvarez-Sangabriel, Marissa A. Silva-García, Alex D. Pacheco-Bouthiller, Jorge A. Aldrete-Velazco, Carlos A. Guizar-Sánchez, Efraín Gaxiola-López, Arturo Guerra-López, Lourdes Figueiras-Graillet, Gustavo Sánchez-Miranda, Genaro H. Mendoza-Zavala, Moisés Aceves-García, Adolfo Chávez-Negrete, Marisol Arroyo-Hernández, Bertha B. Montaño-Velázquez, Luis F. Romero-Moreno, María M. Baquero-Hoyos, Liliana Velasco-Hidalgo, Ana L. Rodríguez-Lozano, Nancy E. Aguilar-Gómez, Mario Rodríguez-Vega, and Jorge E. Cossío-Aranda
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Insuficiencia cardiaca crónica. Guía de práctica clínica. Revisiones sistemáticas. ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
La insuficiencia cardiaca crónica sigue siendo unas de las principales causas de afectación en el funcionamiento y en la calidad de vida de las personas que la presentan, así como una de las primeras causas de mortalidad en nuestro país y en todo el mundo. México tiene una alta prevalencia de factores de riesgo para desarrollar insuficiencia cardiaca, tales como hipertensión arterial, diabetes y obesidad, lo que hace imprescindible contar con un documento basado en la evidencia que brinde recomendaciones a los profesionales de la salud involucrados en el diagnóstico y el tratamiento de estos pacientes. Este documento establece la guía de práctica clínica (GPC) elaborada por iniciativa de la Sociedad Mexicana de Cardiología (SMC) en colaboración con la Agencia Iberoamericana de Desarrollo y Evaluación de Tecnologías en Salud, con la finalidad de establecer recomendaciones basadas en la mejor evidencia disponible y consensuadas por un grupo interdisciplinario y multicolaborativo de expertos. Cumple con estándares internacionales de calidad, como los descritos por el Institute of Medicine de los Estados Unidos de América (IOM), el National Institute of Clinical Excellence (NICE) del Reino Unido, la Intercollegiate Network for Scottish Guideline Development (SIGN) de Escocia y la Guidelines International Network (G-I-N). El grupo de desarrollo de la guía se integró de manera interdisciplinaria con el apoyo de metodólogos con experiencia en revisiones sistemáticas de la literatura y en el desarrollo de GPC. Se llevó a cabo y se condujo metodología de panel Delphi modificado para lograr un nivel de consenso adecuado en cada una de las recomendaciones contenidas en esta GPC. Esperamos que este documento contribuya para la mejor toma de decisiones clínicas y se convierta en un punto de referencia para los clínicos que manejan pacientes con insuficiencia cardiaca crónica en todas sus etapas clínicas, y de esta manera logremos mejorar la calidad en la atención clínica, aumentar la calidad de vida de los pacientes y disminuir las complicaciones de la enfermedad.
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- 2024
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6. Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease
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R. López-Cuevas, M. Baquero-Toledo, A. Cuevas-Jiménez, N. Martín-Ibáñez, R. Pascual-Costa, M.J. Moreno-Monedero, A. Cañada-Martínez, C. Peña-Bautista, I. Ferrer-Cairols, L. Álvarez-Sánchez, and C. Cháfer-Pericás
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Deterioro cognitivo leve ,Demencia ,Enfermedad de Alzheimer ,Biomarcadores ,Pronóstico ,Proteína tau ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available. We selected patients diagnosed with mild cognitive impairment due to AD (National Institute on Aging-Alzheimer’s Association clinical criteria), confirmed neuropsychological deficit, a Global Deterioration Scale score of 3, and an abnormal profile of cerebrospinal fluid biomarkers. Of the 588 cases reviewed, 110 met the inclusion criteria. During follow-up, 50 cases (45.45%) progressed to dementia due to AD. Baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. After adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28–3.84]; P = .004). Among patients with mild cognitive impairment due to AD and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia. Resumen: Realizamos un análisis retrospectivo de los pacientes evaluados en nuestra unidad de memoria en los que se realizó determinación de biomarcadores licuorales de enfermedad de Alzheimer (EA). Se seleccionaron aquellos casos con diagnóstico de deterioro cognitivo leve debido a EA según criterios clínicos (criterios NIA-AA), déficit neuropsicológico comprobado, una puntuación igual a 3 en la escala GDS y un perfil alterado de biomarcadores en líquido cefalorraquídeo. De los 588 casos revisados, 110 cumplieron los criterios de inclusión. Durante el seguimiento, 50 de estos 110 casos (45,45%) progresaron a demencia por EA. Se observaron diferencias significativas en los niveles basales de tau total y tau fosforilada entre los casos que evolucionaron a demencia y los que permanecieron estables como deterioro cognitivo leve, siendo los niveles más altos en el grupo que progresó a demencia. Después del ajuste por edad, sexo, antecedentes de hipertensión, diabetes y nivel educativo, un aumento del 10% en los valores de proteína tau total se asoció con un aumento del 7,60% en el riesgo de progresión a demencia (HR = 2,22, IC 95% [1,28, 3.84], P = .004). En pacientes con deterioro cognitivo leve debido a EA un perfil alterado de biomarcadores licuorales, concentraciones progresivamente mayores de tau-t y tau-p se asocian a un mayor riesgo de conversión a demencia.
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- 2023
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7. Overview of the EUROfusion Tokamak Exploitation programme in support of ITER and DEMO
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E. Joffrin, M. Wischmeier, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the MAST-U Team, the TCV Team, the WEST Team, the EUROfusion Tokamak Exploitation Team:, D. Abate, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, J. Allcock, M. Alonzo, G. Anastasiou, E. Andersson Sunden, C. Angioni, Y. Anquetin, L. Appel, G.M. Apruzzese, M. Ariola, C. Arnas, J.F. Artaud, W. Arter, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, J. Ayllon, E. Aymerich, A. Baciero, F. Bagnato, L. Bähner, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, M. Balden, A. Balestri, M. Baquero Ruiz, T. Barberis, C. Barcellona, O. Bardsley, S. Benkadda, T. Bensadon, E. Bernard, M. Bernert, H. Betar, R. Bianchetti Morales, J. Bielecki, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, P. Blanchard, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, K. Bogar, P. Bohm, T. Bolzonella, F. Bombarda, N. Bonanomi, L. Boncagni, D. Bonfiglio, R. Bonifetto, M. Bonotto, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, C. Bowman, S. Brezinsek, D. Brida, F. Brochard, R. Brunet, D. Brunetti, V. Bruno, R. Buchholz, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, J. Cai, R. Calado, J. Caloud, S. Cancelli, F. Cani, B. Cannas, M. Cappelli, S. Carcangiu, A. Cardinali, S. Carli, D. Carnevale, M. Carole, M. Carpita, D. Carralero, F. Caruggi, I.S. Carvalho, I. Casiraghi, A. Casolari, F.J. Casson, C. Castaldo, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C.D. Challis, R. Chandra, A. Chankin, B. Chapman, H. Chen, M. Chernyshova, A.G. Chiariello, P. Chmielewski, A. Chomiczewska, C. Cianfarani, G. Ciraolo, J. Citrin, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, I.H. Coffey, C. Colandrea, L. Colas, S. Conroy, C. Contre, N.J. Conway, L. Cordaro, Y. Corre, D. Costa, S. Costea, D. Coster, X. Courtois, C. Cowley, T. Craciunescu, G. Croci, A.M. Croitoru, K. Crombe, D.J. Cruz Zabala, G. Cseh, T. Czarski, A. Da Ros, A. Dal Molin, M. Dalla Rosa, Y. Damizia, O. D’Arcangelo, P. David, M. De Angeli, E. De la Cal, E. De La Luna, G. De Tommasi, J. Decker, R. Dejarnac, D. Del Sarto, G. Derks, C. Desgranges, P. Devynck, S. Di Genova, L.E. di Grazia, A. Di Siena, M. Dicorato, M. Diez, M. Dimitrova, T. Dittmar, L. Dittrich, J.J. Domínguez Palacios Durán, P. Donnel, D. Douai, S. Dowson, S. Doyle, M. Dreval, P. Drews, L. Dubus, R. Dumont, D. Dunai, M. Dunne, A. Durif, F. Durodie, G. Durr Legoupil Nicoud, B. Duval, R. Dux, T. Eich, A. Ekedahl, S. Elmore, G. Ericsson, J. Eriksson, B. Eriksson, F. Eriksson, S. Ertmer, A. Escarguel, B. Esposito, T. Estrada, E. Fable, M. Faitsch, N. Fakhrayi Mofrad, A. Fanni, T. Farley, M. Farník, N. Fedorczak, F. Felici, X. Feng, J. Ferreira, D. Ferreira, N. Ferron, O. Fevrier, O. Ficker, A.R. Field, A. Figueiredo, N. Fil, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, M. Flebbe, M. Fontana, J. Fontdecaba Climent, A. Frank, E. Fransson, L. Frassinetti, D. Frigione, S. Futatani, R. Futtersack, S. Gabriellini, D. Gadariya, D. Galassi, K. Galazka, J. Galdon, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, J. Garcia, M. Garcia Munoz, J. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, M. Gelfusa, J. Gerardin, S.N. Gerasimov, R. Gerru Miguelanez, G. Gervasini, Z. Ghani, F.M. Ghezzi, G. Ghillardi, L. Giannone, S. Gibson, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, T. Gleiter, M. Gobbin, V. Goloborodko, A. González Ganzábal, T. Goodman, V. Gopakumar, G. Gorini, T. Görler, S. Gorno, G. Granucci, D. Greenhouse, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, A. Gude, C. Guillemaut, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, J. Hall, C.J. Ham, M. Hamed, T. Happel, G. Harrer, J. Harrison, D. Harting, N.C. Hawkes, P. Heinrich, S. Henderson, P. Hennequin, R. Henriques, S. Heuraux, J. Hidalgo Salaverri, J. Hillairet, J.C. Hillesheim, A. Hjalmarsson, A. Ho, J. Hobirk, E. Hodille, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, L. Horvath, M. Houry, K. Hromasova, J. Huang, Z. Huang, A. Huber, E. Huett, P. Huynh, A. Iantchenko, M. Imrisek, P. Innocente, C. Ionita Schrittwieser, H. Isliker, P. Ivanova, I. Ivanova Stanik, M. Jablczynska, S. Jachmich, A.S. Jacobsen, P. Jacquet, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, T. Jensen, I. Jepu, S. Jessica, T. Johnson, A. Juven, J. Kalis, J. Karhunen, R. Karimov, A.N. Karpushov, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, W. Kernbichler, HT. Kim, D.B. King, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, F. Kjær, E. Klinkby, A. Knieps, U. Knoche, M. Kochan, F. Köchl, G. Kocsis, J.T.W. Koenders, L. Kogan, Y. Kolesnichenko, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovacic, Y. Kovtun, E. Kowalska Strzeciwilk, K. Koziol, M. Kozulia, A. Krämer Flecken, A. Kreter, K. Krieger, U. Kruezi, O. Krutkin, O. Kudlacek, U. Kumar, H. Kumpulainen, M.H. Kushoro, R. Kwiatkowski, M. La Matina, M. Lacquaniti, L. Laguardia, P. Lainer, P. Lang, M. Larsen, E. Laszynska, K.D. Lawson, A. Lazaros, E. Lazzaro, M.Y.K. Lee, S. Leerink, M. Lehnen, M. Lennholm, E. Lerche, Y. Liang, A. Lier, J. Likonen, O. Linder, B. Lipschultz, A. Listopad, X. Litaudon, E. Litherland Smith, D. Liuzza, T. Loarer, P.J. Lomas, J. Lombardo, N. Lonigro, R. Lorenzini, C. Lowry, T. Luda di Cortemiglia, A. Ludvig Osipov, T. Lunt, V. Lutsenko, E. Macusova, R. Mäenpää, P. Maget, C.F. Maggi, J. Mailloux, S. Makarov, K. Malinowski, P. Manas, A. Mancini, D. Mancini, P. Mantica, M. Mantsinen, J. Manyer, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, M. Markl, T. Markovic, D. Marocco, S. Marsden, L. Martellucci, P. Martin, C. Martin, F. Martinelli, L. Martinelli, J.R. Martin Solis, R. Martone, M. Maslov, R. Masocco, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, M.L. Mayoral, D. Mazon, S. Mazzi, C. Mazzotta, G. McArdle, R. McDermott, K. McKay, A.G. Meigs, C. Meineri, A. Mele, V. Menkovski, S. Menmuir, A. Merle, H. Meyer, K. Mikszuta Michalik, D. Milanesio, F. Militello, A. Milocco, I.G. Miron, J. Mitchell, R. Mitteau, V. Mitterauer, J. Mlynar, V. Moiseenko, P. Molna, F. Mombelli, C. Monti, A. Montisci, J. Morales, P. Moreau, J.M. Moret, A. Moro, D. Moulton, P. Mulholland, M. Muraglia, A. Murari, A. Muraro, P. Muscente, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, E. Nardon, M.F. Nave, R.D. Nem, A. Nielsen, S.K. Nielsen, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, R. Ochoukov, N. Offeddu, S. Olasz, C. Olde, F. Oliva, D. Oliveira, H.J.C. Oliver, P. Ollus, J. Ongena, F.P. Orsitto, N. Osborne, R. Otin, P. Oyola Dominguez, D.I. Palade, S. Palomba, O. Pan, N. Panadero, E. Panontin, A. Papadopoulos, P. Papagiannis, G. Papp, V.V. Parail, C. Pardanaud, J. Parisi, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, A. Patel, B. Patel, A. Pau, G. Pautasso, R. Pavlichenko, E. Pawelec, B. Pegourie, G. Pelka, E. Peluso, A. Perek, E. Perelli Cippo, C. Perez Von Thun, P. Petersson, G. Petravich, Y. Peysson, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, F. Pisano, U. Plank, B. Ploeckl, V. Plyusnin, A. Podolnik, Y. Poels, G. Pokol, J. Poley, G. Por, M. Poradzinski, F. Porcelli, L. Porte, C. Possieri, A. Poulsen, I. Predebon, G. Pucella, M. Pueschel, P. Puglia, O. Putignano, T. Pütterich, V. Quadri, A. Quercia, M. Rabinski, L. Radovanovic, R. Ragona, H. Raj, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Refy, M. Reich, H. Reimerdes, B.C.G. Reman, O. Renders, C. Reux, D. Ricci, M. Richou, S. Rienacker, D. Rigamonti, F. Rigollet, F.G. Rimini, D. Ripamonti, N. Rispoli, N. Rivals, J.F. Rivero Rodriguez, C. Roach, G. Rocchi, S. Rode, P. Rodrigues, J. Romazanov, C.F. Romero Madrid, J. Rosato, R. Rossi, G. Rubino, J. Rueda Rueda, J. Ruiz Ruiz, P. Ryan, D. Ryan, S. Saarelma, R. Sabot, M. Salewski, A. Salmi, L. Sanchis, A. Sand, J. Santos, K. Särkimäki, M. Sassano, O. Sauter, G. Schettini, S. Schmuck, P. Schneider, N. Schoonheere, R. Schramm, R. Schrittwieser, C. Schuster, N. Schwarz, F. Sciortino, M. Scotto D’Abusco, S. Scully, A. Selce, L. Senni, M. Senstius, G. Sergienko, S.E. Sharapov, R. Sharma, A. Shaw, U. Sheikh, G. Sias, B. Sieglin, S.A. Silburn, C. Silva, A. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, J. Simpson, L. Singh, S. Sipilä, Y. Siusko, S. Smith, A. Snicker, E.R. Solano, V. Solokha, M. Sos, C. Sozzi, F. Spineanu, G. Spizzo, M. Spolaore, L. Spolladore, C. Srinivasan, A. Stagni, Z. Stancar, G. Stankunas, J. Stober, P. Strand, C.I. Stuart, F. Subba, G.Y. Sun, H.J. Sun, W. Suttrop, J. Svoboda, T. Szepesi, G. Szepesi, B. Tal, T. Tala, P. Tamain, G. Tardini, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, A. Terra, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, E. Thoren, A. Thornton, A. Thrysoe, Q. TICHIT, W. Tierens, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, E. Tonello, A. Tookey, M. Toscano Jiménez, C. Tsironis, C. Tsui, A. Tykhyy, M. Ugoletti, M. Usoltseva, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, SI. Valvis, M. van Berkel, D. Van Eester, S. Van Mulders, M. van Rossem, R. Vann, B. Vanovac, J. Varela Rodriguez, J. Varje, S. Vartanian, M. Vecsei, L. Velarde Gallardo, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, G. Verona Rinati, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, B. Vincent, P. Vincenzi, M.O. Vlad, G. Vogel, I. Voitsekhovitch, I. Voldiner, P. Vondracek, N.M.T. VU, T. Vuoriheimo, C. Wade, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, D. Weston, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, T. Wilson, A. Wojenski, C. Wuethrich, I. Wyss, L. Xiang, S. Xu, D. Yadykin, Y. Yakovenko, H. Yang, V. Yanovskiy, R. Yi, B. Zaar, G. Zadvitskiy, L. Zakharov, P. Zanca, D. Zarzoso, Y. Zayachuk, J. Zebrowski, M. Zerbini, P. Zestanakis, C. F. B. Zimmermann, M. Zlobinski, A. Zohar, V.K. Zotta, X. Zou, M. Zuin, M. Zurita, and I. Zychor
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JET ,ASDEX Upgrade ,MAST-U ,TCV ,WEST ,Tokamak Exploitation Task Force ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Within the 9th European Framework programme, since 2021 EUROfusion is operating five tokamaks under the auspices of a single Task Force called ‘Tokamak Exploitation’. The goal is to benefit from the complementary capabilities of each machine in a coordinated way and help in developing a scientific output scalable to future largre machines. The programme of this Task Force ensures that ASDEX Upgrade, MAST-U, TCV, WEST and JET (since 2022) work together to achieve the objectives of Missions 1 and 2 of the EUROfusion Roadmap: i) demonstrate plasma scenarios that increase the success margin of ITER and satisfy the requirements of DEMO and, ii) demonstrate an integrated approach that can handle the large power leaving ITER and DEMO plasmas. The Tokamak Exploitation task force has therefore organized experiments on these two missions with the goal to strengthen the physics and operational basis for the ITER baseline scenario and for exploiting the recent plasma exhaust enhancements in all four devices (PEX: Plasma EXhaust) for exploring the solution for handling heat and particle exhaust in ITER and develop the conceptual solutions for DEMO. The ITER Baseline scenario has been developed in a similar way in ASDEX Upgrade, TCV and JET. Key risks for ITER such as disruptions and run-aways have been also investigated in TCV, ASDEX Upgrade and JET. Experiments have explored successfully different divertor configurations (standard, super-X, snowflakes) in MAST-U and TCV and studied tungsten melting in WEST and ASDEX Upgrade. The input from the smaller devices to JET has also been proven successful to set-up novel control schemes on disruption avoidance and detachment.
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- 2024
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8. Experimental research on the TCV tokamak
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B.P. Duval, A. Abdolmaleki, M. Agostini, C.J. Ajay, S. Alberti, E. Alessi, G. Anastasiou, Y. Andrèbe, G.M. Apruzzese, F. Auriemma, J. Ayllon-Guerola, F. Bagnato, A. Baillod, F. Bairaktaris, L. Balbinot, A. Balestri, M. Baquero-Ruiz, C. Barcellona, M. Bernert, W. Bin, P. Blanchard, J. Boedo, T. Bolzonella, F. Bombarda, L. Boncagni, M. Bonotto, T.O.S.J. Bosman, D. Brida, D. Brunetti, J. Buchli, J. Buerman, P. Buratti, A. Burckhart, D. Busil, J. Caloud, Y. Camenen, A. Cardinali, S. Carli, D. Carnevale, F. Carpanese, M. Carpita, C. Castaldo, F. Causa, J. Cavalier, M. Cavedon, J.A. Cazabonne, J. Cerovsky, B. Chapman, M. Chernyshova, P. Chmielewski, A. Chomiczewska, G. Ciraolo, S. Coda, C. Colandrea, C. Contré, R. Coosemans, L. Cordaro, S. Costea, T. Craciunescu, K. Crombe, A. Dal Molin, O. D’Arcangelo, D. de Las Casas, J. Decker, J. Degrave, H. de Oliveira, G.L. Derks, L.E. di Grazia, C. Donner, M. Dreval, M.G. Dunne, G. Durr-Legoupil-Nicoud, B. Esposito, T. Ewalds, M. Faitsch, M. Farník, A. Fasoli, F. Felici, J. Ferreira, O. Février, O. Ficker, A. Frank, E. Fransson, L. Frassinetti, L. Fritz, I. Furno, D. Galassi, K. Gałązka, J. Galdon-Quiroga, S. Galeani, C. Galperti, S. Garavaglia, M. Garcia-Munoz, P. Gaudio, M. Gelfusa, J. Genoud, R. Gerrú Miguelanez, G. Ghillardi, M. Giacomin, L. Gil, A. Gillgren, C. Giroud, T. Golfinopoulos, T. Goodman, G. Gorini, S. Gorno, G. Grenfell, M. Griener, M. Gruca, T. Gyergyek, R. Hafner, M. Hamed, D. Hamm, W. Han, G. Harrer, J.R. Harrison, D. Hassabis, S. Henderson, P. Hennequin, J. Hidalgo-Salaverri, J-P. Hogge, M. Hoppe, J. Horacek, A. Huber, E. Huett, A. Iantchenko, P. Innocente, C. Ionita-Schrittwieser, I. Ivanova Stanik, M. Jablczynska, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A.E. Järvinen, J. Kalis, R. Karimov, A.N. Karpushov, K. Kavukcuoglu, J. Kay, Y. Kazakov, J. Keeling, A. Kirjasuo, J.T.W. Koenders, P. Kohli, M. Komm, M. Kong, J. Kovacic, E. Kowalska-Strzeciwilk, O. Krutkin, O. Kudlacek, U. Kumar, R. Kwiatkowski, B. Labit, L. Laguardia, E. Laszynska, A. Lazaros, K. Lee, E. Lerche, B. Linehan, D. Liuzza, T. Lunt, E. Macusova, D. Mancini, P. Mantica, M. Maraschek, G. Marceca, S. Marchioni, A. Mariani, M. Marin, A. Marinoni, L. Martellucci, Y. Martin, P. Martin, L. Martinelli, F. Martinelli, J.R. Martin-Solis, S. Masillo, R. Masocco, V. Masson, A. Mathews, M. Mattei, D. Mazon, S. Mazzi, S.Y. Medvedev, C. Meineri, A. Mele, V. Menkovski, A. Merle, H. Meyer, K. Mikszuta-Michalik, I.G. Miron, P.A. Molina Cabrera, A. Moro, A. Murari, P. Muscente, D. Mykytchuk, F. Nabais, F. Napoli, R.D. Nem, M. Neunert, S.K. Nielsen, A. Nielsen, M. Nocente, S. Noury, S. Nowak, H. Nyström, N. Offeddu, S. Olasz, F. Oliva, D.S. Oliveira, F.P. Orsitto, N. Osborne, P. Oyola Dominguez, O. Pan, E. Panontin, A.D. Papadopoulos, P. Papagiannis, G. Papp, M. Passoni, F. Pastore, A. Pau, R.O. Pavlichenko, A.C. Pedersen, M. Pedrini, G. Pelka, E. Peluso, A. Perek, C. Perez Von Thun, F. Pesamosca, D. Pfau, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, U. Plank, V. Plyusnin, Y.R.J. Poels, G.I. Pokol, J. Poley-Sanjuan, M. Poradzinski, L. Porte, C. Possieri, A. Poulsen, M.J. Pueschel, T. Pütterich, V. Quadri, M. Rabinski, R. Ragona, H. Raj, A. Redl, H. Reimerdes, C. Reux, D. Ricci, M. Riedmiller, S. Rienäcker, D. Rigamonti, N. Rispoli, J.F. Rivero-Rodriguez, C.F. Romero Madrid, J. Rueda Rueda, P.J. Ryan, M. Salewski, A. Salmi, M. Sassano, O. Sauter, N. Schoonheere, R.W. Schrittwieser, F. Sciortino, A. Selce, L. Senni, S. Sharapov, U.A. Sheikh, B. Sieglin, M. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, E.R. Solano, C. Sozzi, M. Spolaore, L. Spolladore, A. Stagni, P. Strand, G. Sun, W. Suttrop, J. Svoboda, B. Tal, T. Tala, P. Tamain, M. Tardocchi, A. Tema Biwole, A. Tenaglia, D. Terranova, D. Testa, C. Theiler, A. Thornton, A.S. Thrysoe, M. Tomes, E. Tonello, H. Torreblanca, B. Tracey, M. Tsimpoukelli, C. Tsironis, C.K. Tsui, M. Ugoletti, M. Vallar, M. van Berkel, S. van Mulders, M. van Rossem, C. Venturini, M. Veranda, T. Verdier, K. Verhaegh, L. Vermare, N. Vianello, E. Viezzer, F. Villone, B. Vincent, P. Vincenzi, I. Voitsekhovitch, L. Votta, N.M.T. Vu, Y. Wang, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, S. Wiesen, M. Wiesenberger, T. Wijkamp, C. Wüthrich, D. Yadykin, H. Yang, V. Yanovskiy, J. Zebrowski, P. Zestanakis, M. Zuin, and M. Zurita
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TCV ,review ,plasma ,SPC ,EPFL ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Tokamak à configuration variable (TCV), recently celebrating 30 years of near-continual operation, continues in its missions to advance outstanding key physics and operational scenario issues for ITER and the design of future power plants such as DEMO. The main machine heating systems and operational changes are first described. Then follow five sections: plasma scenarios. ITER Base-Line (IBL) discharges, triangularity studies together with X3 heating and N2 seeding. Edge localised mode suppression, with a high radiation region near the X-point is reported with N _2 injection with and without divertor baffles in a snowflake configuration. Negative triangularity (NT) discharges attained record, albeit transient, β _N ∼ 3 with lower turbulence, higher low-Z impurity transport, vertical stability and density limits and core transport better than the IBL. Positive triangularity L-Mode linear and saturated ohmic confinement confinement saturation, often-correlated with intrinsic toroidal rotation reversals, was probed for D, H and He working gases. H-mode confinement and pedestal studies were extended to low collisionality with electron cyclotron heating obtaining steady state electron iternal transport barrier with neutral beam heating (NBH), and NBH driven H-mode configurations with off-axis co-electron cyclotron current drive. Fast particle physics. The physics of disruptions, runaway electrons and fast ions (FIs) was developed using near-full current conversion at disruption with recombination thresholds characterised for impurity species (Ne, Ar, Kr). Different flushing gases (D2, H2) and pathways to trigger a benign disruption were explored. The 55 kV NBH II generated a rich Alfvénic spectrum modulating the FI fas ion loss detector signal. NT configurations showed less toroidal Alfvén excitation activity preferentially affecting higher FI pitch angles. Scrape-off layer and edge physics. gas puff imaging systems characterised turbulent plasma ejection for several advanced divertor configurations, including NT. Combined diagnostic array divertor state analysis in detachment conditions was compared to modelling revealing an importance for molecular processes. Divertor physics. Internal gas baffles diversified to include shorter/longer structures on the high and/or low field side to probe compressive efficiency. Divertor studies concentrated upon mitigating target power, facilitating detachment and increasing the radiated power fraction employing alternative divertor geometries, optimised X-point radiator regimes and long-legged configurations. Smaller-than-expected improvements with total flux expansion were better modelled when including parallel flows. Peak outer target heat flux reduction was achieved (>50%) for high flux-expansion geometries, maintaining core performance ( H _98 > 1). A reduction in target heat loads and facilitated detachment access at lower core densities is reported. Real-time control. TCV’s real-time control upgrades employed MIMO gas injector control of stable, robust, partial detachment and plasma β feedback control avoiding neoclassical tearing modes with plasma confinement changes. Machine-learning enhancements include trajectory tracking disruption proximity and avoidance as well as a first-of-its-kind reinforcement learning-based controller for the plasma equilibrium trained entirely on a free-boundary simulator. Finally, a short description of TCV’s immediate future plans will be given.
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- 2024
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- View/download PDF
9. Holistic approach of the care of the infant with hypoxic-ischaemic encephalopathy in Spain
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Juan Arnaez, Nuria Herranz-Rubia, Alfredo Garcia-Alix, J. Diez-Delgado, I. Benavente-Fernández, I. Tofé, A.E. Jerez, J.A. Hurtado, J.M. Ceballos, M.L. Millán, M.D. Esquivel, C. Ruiz, M. Baca, E. Tapia, M. Losada, E. Torres, A. Pavón, P.J. Jiménez, F. Jiménez, M.P. Ventura, S. Rite, T. González, R.P. Arias, P.R. Balliu, J.M. Lloreda-García, J.L. Alcaráz, C. Tapia, A. de la Morena, I. Centelles, I. Güemes, J. Estañ, A. Alberola, S. Aparici, R. López, J. Beceiro, B. García, L. Martínez, E. González, L. Arruza, M.D. Blanco, M.T. Moral, B. Arias, F. Mar, J. Jiménez, G. Romera, A. Cuñarro, C. Muñóz, F. Cabañas, E. Valverde, R. Montero, J.C. Tejedor, C. Santana, B. Reyes, S. Romero, A. Orizaola, M. Baquero, D. Hernández, A. Pantoja, C. Vega-del-Val, L. Castañón, E.P. Gutiérrez, M. Benito, S. Caserío, G. Arca, M.J. García, M.A. López-Vílchez, L. Castells, M. Domingo, W. Coroleu, H. Boix, R. Porta, A. García-Alix, S. Martínez-Nadal, E. Jiménez, E. Sole, M. Albújar, E.M. Fernández, A.R. Barrio, E. Piñán, A. Avila-Alvarez, M.E. Vázquez, N. Balado, P.A. Crespo, M.L. Couce, A. Concheiro-Guisán, I. Esteban, A. Lavilla, V. Alzina, A. Aguirre, B. Loureiro, I. Echániz, M.D. Elorza, and A. Euba
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Hipoxia-isquemia ,Asfixia ,Neonato ,Hipotermia terapéutica ,Biomarcadores ,Pronóstico ,Pediatrics ,RJ1-570 - Abstract
Introduction: There is not much information about the care of infants with hypoxic-ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) in Spain. This includes whether protocols are routinely used, the type of neuro-monitoring performed, and how information on the neurological prognosis is presented to families. The answers to these would allow to detect and implement areas of improvement. Method: A cross-sectional analysis was performed on the responses to structured questionnaires sent to all the Spanish neonatal units that were performing TH in June 2015. Questions were divided into 5 sections: (1) the availability of protocols and technological resources, (2) the use of neuro-monitoring tools, (3) the knowledge and training of the professionals; (4) the prognostic information given to the parents; and (5) the discharge report and the follow-up plan. Results: Most centres (95%) use servo controlled whole-body cooling methods and have specific management protocols. Sedation is used in 70% of centres, and in 68% of them the onset of enteral feeding is delayed until the end of the cooling period. Amplitude-integrated electroencephalography monitoring is used in more than 80% of the centres, although only in 50% are nurses able to interpret it. Cerebral oxygen saturation is not often monitored (16%). As regards diagnostic-prognostic studies, neuroimaging is universal, but brain damage biomarkers are hardly used (29%). Prognostic information is offered within the first 72 posnatal hours in 21% of the centres, and is given without the presence of the nurse in 70% of the centres. Follow-up is performed by a neuro-paediatrician (84%), with an uneven duration between centres. Conclusions: The care of infants with HIE treated with TH in Spain is generally adequate, although there are areas for improvement in neuromonitoring, sedation, prognostic information, teamwork, and duration of follow-up. Resumen: Introducción: Apenas conocemos cómo es la asistencia de los recién nacidos (RN) con encefalopatía hipóxico-isquémica (EHI) en hipotermia terapéutica (HT), especialmente si existen protocolos asistenciales, la neuromonitorización que se realiza o cómo es la aproximación al pronóstico neurológico. Este conocimiento permite detectar e implementar áreas de mejora asistencial. Método: Estudio transversal de los 57 hospitales españoles que realizaban HT en 2015, mediante cuestionario sobre: 1) la disponibilidad de protocolos y de recursos tecnológicos; 2) el uso de herramientas de neuromonitorización; 3) los conocimientos de los profesionales; 4) la información pronóstica que se da los padres, y 5) el informe al alta y del plan de seguimiento. Resultados: El 95% utiliza enfriamiento corporal-total servocontrolado y dispone de protocolos específicos de actuación. El 70% utiliza sedación y el 68% deja al paciente a dieta absoluta. La monitorización con electroencefalografía integrada por amplitud se utiliza en más del 80% de los centros, aunque solo en el 50% la enfermera es capaz de interpretarlo. La saturación de oxígeno cerebral es escasamente monitorizada (16%). Entre los estudios diagnóstico-pronósticos, la neuroimagen es universal, pero los neurobiomarcadores apenas se utilizan (29%). Solo el 21% ofrece información pronóstica antes de las 72 h de vida; sin presencia de la enfermera en el 70%. El seguimiento lo realiza el neuropediatra (84%), con una duración desigual entre centros. Conclusiones: La asistencia del RN con EHI en España es adecuada, con áreas de mejora en: neuromonitorización, sedación, marco temporal de la información pronóstica, trabajo en equipo y estandarización de la duración del seguimiento.
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- 2020
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- View/download PDF
10. Atención integral del neonato con encefalopatía hipóxico-isquémica en España
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Juan Arnaez, Nuria Herranz-Rubia, Alfredo Garcia-Alix, J. Diez-Delgado, I. Benavente-Fernández, I. Tofé, A.E. Jerez, J.A. Hurtado, J.M. Ceballos, M.L. Millán, M.D. Esquivel, C. Ruiz, M. Baca, E. Tapia, M. Losada, E. Torres, A. Pavón, P.J. Jiménez, F. Jiménez, M.P. Ventura, S. Rite, T. González, R.P. Arias, P.R. Balliu, J.M. Lloreda-García, J.L. Alcaráz, C. Tapia, A. de la Morena, I. Centelles, I. Güemes, J. Estañ, A. Alberola, S. Aparici, R. López, J. Beceiro, B. García, L. Martínez, E. González, L. Arruza, M.D. Blanco, M.T. Moral, B. Arias, F. Mar, J. Jiménez, G. Romera, A. Cuñarro, C. Muñóz, F. Cabañas, E. Valverde, R. Montero, J.C. Tejedor, C. Santana, B. Reyes, S. Romero, A. Orizaola, M. Baquero, D. Hernández, A. Pantoja, C. Vega-del-Val, L. Castañón, E.P. Gutiérrez, M. Benito, S. Caserío, G. Arca, M.J. García, M.A. López-Vílchez, L. Castells, M. Domingo, W. Coroleu, H. Boix, R. Porta, A. García-Alix, S. Martínez-Nadal, E. Jiménez, E. Sole, M. Albújar, E.M. Fernández, A.R. Barrio, E. Piñán, A. Avila-Alvarez, M.E. Vázquez, N. Balado, P.A. Crespo, M.L. Couce, A. Concheiro-Guisán, I. Esteban, A. Lavilla, V. Alzina, A. Aguirre, B. Loureiro, I. Echániz, M.D. Elorza, and A. Euba
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Hypoxia-ischaemia ,Asphyxia ,Newborn ,Therapeutic hypothermia ,Biomarkers ,Prognosis ,Pediatrics ,RJ1-570 - Abstract
Resumen: Introducción: Apenas conocemos cómo es la asistencia de los recién nacidos (RN) con encefalopatía hipóxico-isquémica (EHI) en hipotermia terapéutica (HT), especialmente si existen protocolos asistenciales, la neuromonitorización que se realiza o cómo es la aproximación al pronóstico neurológico. Este conocimiento permite detectar e implementar áreas de mejora asistencial. Método: Estudio transversal de los 57 hospitales españoles que realizaban HT en 2015, mediante cuestionario sobre: 1) la disponibilidad de protocolos y de recursos tecnológicos; 2) el uso de herramientas de neuromonitorización; 3) los conocimientos de los profesionales; 4) la información pronóstica que se da los padres, y 5) el informe al alta y del plan de seguimiento. Resultados: El 95% utiliza enfriamiento corporal-total servocontrolado y dispone de protocolos específicos de actuación. El 70% utiliza sedación y el 68% deja al paciente a dieta absoluta. La monitorización con electroencefalografía integrada por amplitud se utiliza en más del 80% de los centros, aunque solo en el 50% la enfermera es capaz de interpretarlo. La saturación de oxígeno cerebral es escasamente monitorizada (16%). Entre los estudios diagnóstico-pronósticos, la neuroimagen es universal, pero los neurobiomarcadores apenas se utilizan (29%). Solo el 21% ofrece información pronóstica antes de las 72 h de vida; sin presencia de la enfermera en el 70%. El seguimiento lo realiza el neuropediatra (84%), con una duración desigual entre centros. Conclusiones: La asistencia del RN con EHI en España es adecuada, con áreas de mejora en: neuromonitorización, sedación, marco temporal de la información pronóstica, trabajo en equipo y estandarización de la duración del seguimiento. Abstract: Introduction: There is not much information about the care of infants with hypoxic-ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) in Spain. This includes whether protocols are routinely used, the type of neuro-monitoring performed, and how information on the neurological prognosis is presented to families. The answers to these would allow to detect and implement areas of improvement. Method: A cross-sectional analysis was performed on the responses to structured questionnaires sent to all the Spanish neonatal units that were performing TH in June 2015. Questions were divided into 5 sections: 1) the availability of protocols and technological resources, 2) the use of neuro-monitoring tools, 3) the knowledge and training of the professionals; 4) the prognostic information given to the parents; and 5) the discharge report and the follow-up plan. Results: Most centres (95%) use servo controlled whole-body cooling methods and have specific management protocols. Sedation is used in 70% of centres, and in 68% of them the onset of enteral feeding is delayed until the end of the cooling period. Amplitude-integrated electroencephalography monitoring is used in more than 80% of the centres, although only in 50% are nurses able to interpret it. Cerebral oxygen saturation is not often monitored (16%). As regards diagnostic-prognostic studies, neuroimaging is universal, but brain damage biomarkers are hardly used (29%). Prognostic information is offered within the first 72 posnatal hours in 21% of the centres, and is given without the presence of the nurse in 70% of the centres. Follow-up is performed by a neuro-paediatrician (84%), with an uneven duration between centres. Conclusions: The care of infants with HIE treated with TH in Spain is generally adequate, although there are areas for improvement in neuromonitoring, sedation, prognostic information, teamwork, and duration of follow-up.
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- 2020
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- View/download PDF
11. Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica
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Abel A. Pavía-López, Marco A. Alcocer-Gamba, Edith D. Ruiz-Gastélum, José L. Mayorga-Butrón, Roopa Mehta, Filiberto A. Díaz-Aragón, Jorge A. Aldrete-Velasco, Nitzia López-Juárez, Ivette Cruz-Bautista, Adolfo Chávez-Mendoza, Nikos C. Secchi-Nicolás, Francisco J. Guerrero-Martínez, Jorge E. Cossio-Aranda, Victoria Mendoza-Zubieta, Guillermo Fanghänel-Salmón, Martha Valdivia-Proa, Luis Olmos-Domínguez, Carlos A. Aguilar-Salinas, Luis Dávila-Maldonado, Armando Vázquez-Rangel, Vanina Pavia-Aubry, María de los A. Nava-Hernández, Carlos A. Hinojosa-Becerril, Juan C. Anda-Garay, Manuel O. de los Ríos-Ibarra, Ana Berni-Betancourt, Julio López-Cuellar, Diego Araiza-Garaygordobil, Romina Rivera-Reyes, Gabriela Borrayo-Sánchez, Mónica Tapia-Hernández, Claudia V. Cano-Nigenda, Arturo Guerra-López, Josué Elías-López, Marco A. Figueroa-Morales, Bertha B. Montaño-Velázquez, Liliana Velasco-Hidalgo, Ana L. Rodríguez-Lozano, Claudia Pimentel-Hernández, María M. Baquero-Hoyos, Felipe Romero-Moreno, and Mario Rodríguez-Vega
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Dislipidemias. Enfermedad cardiovascular. Enfermedad cardiovascular aterosclerótica. Guía de práctica clínica. Revisiones sistemáticas. ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Antecedentes: Las enfermedades cardiovasculares son la principal causa mundial de mortalidad y México no es la excepción. Los datos epidemiológicos obtenidos en 1990 mostraron que los padecimientos cardiovasculares representaron el 19.8% de todas las causas de muerte en nuestro país; esta cifra se incrementó de manera significativa a un 25.5% para 2015. Diversas encuestas nacionales sugieren que más del 60% de la población adulta tiene al menos un factor de riesgo para padecer enfermedades cardiovasculares (obesidad o sobrepeso, hipertensión, tabaquismo, diabetes, dislipidemias). Por otro lado, datos de la Organización Panamericana de la Salud han relacionado el proceso de aterosclerosis como la primer causa de muerte prematura, reduciendo la expectativa de vida de manera sensible, lo que tiene una enorme repercusión social. Objetivo: Este documento constituye la guía de práctica clínica (GPC) elaborada por iniciativa de la Sociedad Mexicana de Cardiología en colaboración con la Sociedad Mexicana de Nutrición y Endocrinología, A.C., Asociación Nacional de Cardiólogos de México, A.C., Asociación Mexicana para la Prevención de la Aterosclerosis y sus Complicaciones, A.C., Comité Normativo Nacional de Medicina General, A.C., Colegio Nacional de Medicina Geriátrica, A.C., Colegio de Medicina Interna de México, A.C., Sociedad Mexicana de Angiología y Cirugía Vascular y Endovenosa, A.C., Instituto Mexicano de Investigaciones Nefrológicas, A.C. y la Academia Mexicana de Neurología, A.C.; con el apoyo metodológico de la Agencia Iberoamericana de Desarrollo y Evaluación de Tecnologías en Salud, con la finalidad de establecer recomendaciones basadas en la mejor evidencia disponible y consensuadas por un grupo interdisciplinario de expertos. El objetivo de este documento es el de brindar recomendaciones basadas en evidencia para ayudar a los tomadores de decisión en el diagnóstico y tratamiento de las dislipidemias en nuestro país. Material y métodos: Este documento cumple con estándares internacionales de calidad, como los descritos por el Instituto de Medicina de EE.UU., el Instituto de Excelencia Clínica de Gran Bretaña, la Red Colegiada para el Desarrollo de Guías de Escocia y la Red Internacional de Guías de Práctica Clínica. Se integró un grupo multidisciplinario de expertos clínicos y metodólogos con experiencia en revisiones sistemáticas de la literatura y el desarrollo de guías de práctica clínica. Se consensuó un documento de alcances, se establecieron las preguntas clínicas relevantes, se identificó de manera exhaustiva la mejor evidencia disponible evaluada críticamente en revisiones sistemáticas de la literatura y se desarrollaron las recomendaciones clínicas. Se utilizó la metodología de Panel Delphi modificado para lograr un nivel de consenso adecuado en cada una de las recomendaciones contenidas en esta GPC. Resultados: Se consensuaron 23 preguntas clínicas que dieron origen a sus respectivas recomendaciones clínicas. Conclusiones: Esperamos que este documento contribuya a la mejor toma de decisiones clínicas y se convierta en un punto de referencia para los clínicos y pacientes en el manejo de las dislipidemias y esto contribuya a disminuir la morbilidad y mortalidad derivada de los eventos cardiovasculares ateroscleróticos en nuestro país.
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- 2022
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12. 4D and 5D phase-space tomography using slowing-down physics regularization
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B.S. Schmidt, M. Salewski, D. Moseev, M. Baquero-Ruiz, P.C. Hansen, J. Eriksson, O. Ford, G. Gorini, H. Järleblad, Ye O. Kazakov, D. Kulla, S. Lazerson, J.E. Mencke, D. Mykytchuk, M. Nocente, P. Poloskei, M. Rud, A. Snicker, L. Stagner, S. Äkäslompolo, and the W7-X Team
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fast ions ,tomography ,slowing-down ,NBI ,Tokamak ,stellarator ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
We compute reconstructions of 4D and 5D fast-ion phase-space distribution functions in fusion plasmas from synthetic projections of these functions. The fast-ion phase-space distribution functions originating from neutral beam injection (NBI) at TCV and Wendelstein 7-X (W7-X) at full, half, and one-third injection energies can be distinguished and particle densities of each component inferred based on 20 synthetic spectra of projected velocities at TCV and 680 at W7-X. Further, we demonstrate that an expansion into a basis of slowing-down distribution functions is equivalent to regularization using slowing-down physics as prior information. Using this technique in a Tikhonov formulation, we infer the particle density fractions for each NBI energy for each NBI beam from synthetic measurements, resulting in six unknowns at TCV and 24 unknowns at W7-X. Additionally, we show that installing 40 LOS in each of 17 ports at W7-X, providing full beam coverage and almost full angle coverage, produces the highest quality reconstructions.
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- 2023
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13. Valor pronóstico de los biomarcadores licuorales en el deterioro cognitivo leve debido a enfermedad de Alzheimer
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M.J. Moreno-Monedero, L. Álvarez-Sánchez, I. Ferrer-Cairols, A. Cuevas-Jiménez, C. Peña-Bautista, Antonio José Cañada-Martínez, N. Martín-Ibáñez, R. López-Cuevas, M. Baquero-Toledo, R. Pascual-Costa, and C. Cháfer-Pericás
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medicine.medical_specialty ,business.industry ,Hazard ratio ,Neuropsychology ,medicine.disease ,Gastroenterology ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,Internal medicine ,Diabetes mellitus ,medicine ,Dementia ,Biomarker (medicine) ,Neurology (clinical) ,Alzheimer's disease ,business ,030217 neurology & neurosurgery - Abstract
We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available. We selected patients diagnosed with mild cognitive impairment due to AD (National Institute on Aging-Alzheimer's Association clinical criteria), confirmed neuropsychological deficit, a Global Deterioration Scale score of 3, and an abnormal profile of cerebrospinal fluid biomarkers. Of the 588 cases reviewed, 110 met the inclusion criteria. During follow-up, 50 cases (45.45%) progressed to dementia due to AD. Baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. After adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28-3.84]; P = .004). Among patients with mild cognitive impairment due to AD and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia.
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- 2023
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14. Protocolo diagnóstico diferencial de la demencia
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M. Baquero and L. Álvarez-Sánchez
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General Medicine - Published
- 2023
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15. A Middle to Late Miocene Trans-Andean Portal: Geologic Record in the Tatacoa Desert
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C. Montes, C. A. Silva, G. A. Bayona, R. Villamil, E. Stiles, A. F. Rodriguez-Corcho, A. Beltran-Triviño, F. Lamus, M. D. Muñoz-Granados, L. C. Pérez-Angel, N. Hoyos, S. Gomez, J. J. Galeano, E. Romero, M. Baquero, A. L. Cardenas-Rozo, and A. von Quadt
- Subjects
Northern Andes ,Andes ,miocene ,drainages ,La Venta ,portal ,Science - Abstract
Integration of several geologic lines of evidence reveals the prevalence of a lowland trans-Andean portal communicating western Amazonia and the westernmost Andes from at least middle Miocene until Pliocene times. Volcanism and crustal shortening built up relief in the southernmost Central and Eastern Cordilleras of Colombia, closing this lowland gap. Independent lines of evidence consist first, of field mapping in the Tatacoa Desert with a coverage area of ∼381 km2, 1,165 km of geological contact traces, 164 structural data points, and 3D aerial digital mapping models. This map documents the beginning of southward propagation of the southernmost tip of the Eastern Cordillera’s west-verging, fold-and-thrust belt between ∼12.2 and 13.7 Ma. Second, a compilation of new and published detrital zircon geochronology in middle Miocene strata of the Tatacoa Desert shows three distinctive age populations: middle Miocene, middle Eocene, and Jurassic; the first two sourced west of the Central Cordillera, the latter in the Magdalena Valley. Similar populations with the three distinctive peaks have now been recovered in western Amazonian middle Miocene strata. These observations, along with published molecular and fossil fish data, suggest that by Serravallian times (∼13 Ma), the Northern Andes were separated from the Central Andes at ∼3°N by a fluvial system that flowed into the Amazon Basin through the Tatacoa Desert. This paleogeographic configuration would be similar to a Western Andean, or Marañon Portal. Late Miocene flattening of the subducting Nazca slab caused the eastward migration of the Miocene volcanic arc, so that starting at ∼4 Ma, large composite volcanoes were built up along the axis of today's Central Cordillera, closing this lowland Andean portal and altering the drainage patterns to resemble a modern configuration.
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- 2021
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16. Care of the newborn with perinatal asphyxia candidate for therapeutic hypothermia during the first six hours of life in Spain
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Juan Arnaez, Alfredo Garcia-Alix, Sara Calvo, Simón Lubián-López, J. Diez-Delgado, I. Benavente, I. Tofé, A.E. Jerez, J.A. Hurtado, J.M. Ceballos, M.L. Millán, M.D. Esquivel, C. Ruiz, M. Baca, E. Tapia, M. Losada, E. Torres, A. Pavón, P.J. Jiménez, F. Jiménez, M.P. Ventura, S. Rite, T. González, R.P. Arias, P.R. Balliu, J.M. Lloreda-García, J.L. Alcaráz, C. Tapia, A. de la Morena, I. Centelles, I. Güemes, J. Estañ, A. Alberola, S. Aparici, R. López, J. Beceiro, B. García, L. Martínez, E. González, L. Arruza, M.D. Blanco, M.T. Moral, B. Arias, F. Mar, J. Jiménez, G. Romera, A. Cuñarro, C. Muñóz, F. Cabañas, E. Valverde, R. Montero, J.C. Tejedor, C. Santana, B. Reyes, S. Romero, A. Orizaola, M. Baquero, D. Hernández, A. Pantoja, C. Vega, L. Castañón, E.P. Gutiérrez, M. Benito, S. Caserío, G. Arca, M.J. García, M.A. López-Vílchez, L. Castells, M. Domingo, W. Coroleu, H. Boix, R. Porta, A. García-Alix, S. Martínez-Nadal, E. Jiménez, E. Sole, M. Albújar, E.M. Fernández, A.R. Barrio, E. Piñán, A. Avila-Alvarez, M.E. Vázquez, N. Balado, P.A. Crespo, M.L. Couce, A. Concheiro-Guisán, I. Esteban, A. Lavilla, V. Alzina, A. Aguirre, B. Loureiro, I. Echániz, and M.D. Elorza A. Euba
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Hipoxia-isquemia ,Asfixia ,Recién nacido ,Hipotermia terapéutica ,España ,Horas de oro ,Pediatrics ,RJ1-570 - Abstract
Introduction: The process of care and assistance from birth to the starting of therapeutic hypothermia (TH) is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury. Methods: A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level III units on the care of the newborn ≥ 35 weeks gestation within the first hours of life after a perinatal asphyxia event. According to clinical practice guidelines, the quality of care was compared between the hospitals that carried out or did not carry out TH, and according to the level of care. Results: A total of 89/90 hospitals participated, of which 57/90 performed TH. They all used resuscitation protocols and turned off the radiant warmer after stabilisation. All of them performed glucose and blood gas analysis, monitored the central temperature, put the newborn on a diet, and performed at least two examinations for the diagnosis of hypoxic-ischaemic encephalopathy. Greater than one-third (35%) of hospitals did not have amplitude-integrated electroencephalogram, and 6/57 were TH-hospitals. The quality of care among hospitals with and without TH was similar, childbirth being better in those that performed TH, and those with a higher level of care. Level IIIc hospitals had higher scores than the others. The TH-hospitals mentioned not always having neonatologists with experience in neurological assessment and interpretation of amplitude-integrated electroencephalogram (25%), or in brain ultrasound (62%). Conclusions: In response to the recommendations of the asphyxiated newborn, there is a proper national health care standard with differences according to the level of care and whether TH is offered. More amplitude-integrated electroencephalogram devices are necessary, as well as more neonatologists trained in the evaluations that will be required by the newborn with hypoxic-ischaemic encephalopathy. Resumen: Introducción: El proceso asistencial hasta el inicio de la hipotermia terapéutica (HT) es crucial para mejorar su efectividad y prevenir el agravamiento del daño hipóxico-isquémico. Método: Estudio transversal nacional realizado en 2015 mediante cuestionario a todas las unidades nivel iii sobre la asistencia al recién nacido (RN) con asfixia perinatal en las primeras horas de vida. Se comparó la calidad asistencial entre los hospitales que realizaban o no HT y según el nivel asistencial, de acuerdo a las guías de práctica clínica. Resultados: Participaron 89/90 hospitales, 57/90 realizaban HT. Todos utilizaban protocolos de reanimación y apagaban la cuna tras estabilización. Fue universal realizar medición de glucemia y gasometría, monitorizar la temperatura, dejar al RN a dieta y realizar al menos 2 exploraciones para el diagnóstico de encefalopatía hipóxico-isquémica. El 35% no disponía de electroencefalograma integrado por amplitud; 6/57 eran hospitales que realizaban HT. La calidad asistencial entre los hospitales con/sin HT fue similar, siendo mejor la del parto en los que hacían HT, y la de aquellos con mayor nivel asistencial. El 25% de aquellos que realizaban HT no tenían neonatólogos con experiencia en la exploración neurológica o en la interpretación del electroencefalograma integrado por amplitud; ni en la realización de ecografía cerebral en el 62%. Conclusiones: Atendiendo a las recomendaciones del RN asfíctico, existe un adecuado estándar asistencial nacional, con diferencias según el nivel asistencial y si realizan o no hipotermia. Son necesarios más equipos de electroencefalograma integrado por amplitud y formación de los neonatólogos en las evaluaciones que requerirá el RN con encefalopatía hipóxico-isquémica.
- Published
- 2018
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17. Resilience to infection by Mycobacterium avium subspecies paratuberculosis following direct intestinal inoculation in calves
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Kevin J. Stinson, Monica M. Baquero, and Brandon L. Plattner
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Veterinary medicine ,SF600-1100 - Abstract
Abstract Mycobacterium avium subspecies paratuberculosis (Map) is the cause of Johne’s disease, a chronic enteritis of cattle. A significant knowledge gap is how persistence of Map within the intestinal tract after infection contributes to progression of disease. To address this, we exposed calves to Map by direct ileocecal Peyer’s patch injection. Our objective was to characterize the persistence of Map in tissues, associated intestinal lesions, fecal Map shedding, and serum antibody responses, through the first 28-weeks post-inoculation (wpi). Previous work using this model showed 100% rate of Map infection in intestine and lymph node by 12 wpi. We hypothesized that direct inoculation of Map into the distal small intestine would induce intestinal Map infection with local persistence and progression towards clinical disease. However, our data show decreased persistence of Map in the distal small intestine and draining lymph nodes. We identified Map in multiple sections of distal ileum and draining lymph node of all calves at 4 and 12 wpi, but then we observed reduced Map in distal ileum at 20 wpi, and by 28 wpi we found that 50% of animals had no detectable Map in intestine or the lymph node. This provides evidence of resilience to Map infection following direct intestinal Map inoculation. Further work examining the immune responses and host–pathogen interactions associated with this infection model are needed to help elicit the mechanisms underlying resilience to Map infection.
- Published
- 2018
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18. X-band microwave modules for both PAZ and RBX novel active radar calibrator system.
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Ana M. Baquero, Laura Ojalvo, David Madrono, Eduardo De Diego, and Juan Ramón Larrañaga Sudupe
- Published
- 2014
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19. Bloqueo atrioventricular de primer grado asociado a bloqueo de rama derecha del haz de His
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Laura M Baquero Bárcenas and Carlos I. Quesada Aguilar
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Trastornos de conducción atrioventricular ,bloqueo atrioventricular ,bloqueo intraventricular ,bloqueo de rama derecha del haz de His. ,Medicine - Abstract
El bloqueo de conducción atrioventricular de primer grado y el bloqueo de rama derecha del haz de His presentan una característica en común: usualmente son asintomáticos. El trastorno de conducción intraventricular se ha asociado con un aumento en el riesgo cardiovascular y con un aumento en la mortalidad por cualquier causa. Los bloqueos AV, a pesar de ser de I grado, se han asociado a un mayor riesgo de muerte, falla cardiaca y fibrilación atrial. Se presenta un electrocardiograma con estos dos hallazgos y una prolongación marcada de la conducción atrioventricular. Se revisará brevemente los criterios diagnósticos y puntos clave en el manejo de estos pacientes.
- Published
- 2018
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20. Infarto agudo al miocardio de cara inferior con posterior revascularización.
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Laura M. Baquero Bárcenas and Carlos I. Quesada Aguilar
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Infarto agudo al miocardio con elevación del segmento ST ,intervención coronaria percutánea (ICP) ,infarto de cara inferior ,arteria coronaria derecha. ,Medicine - Abstract
El infarto agudo al miocardio con elevación del ST (IAMCEST) es una entidad de muy alta mor-talidad y con alta probabilidad de complicacio-nes asociadas. Como primicia, tras el diagnóstico inicial de un infarto agudo al miocardio con elevación del segmento ST el manejo debe estar enfocado hacia la restauración de la perfusión coronaria lo más pronto posible. Se presenta el caso electrocardiográfico de un infarto agudo al miocardio con elevación del ST de cara inferior, representado por las derivaciones aVF, D II y D III, que fue manejado con intervención mecánica temprana. Se revisarán los puntos clave en el diagnóstico de estos casos así como los funda-mentos del manejo.
- Published
- 2018
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21. Bovine WC1+ and WC1neg γδ T Lymphocytes Influence Monocyte Differentiation and Monocyte-Derived Dendritic Cell Maturation during In Vitro Mycobacterium avium Subspecies paratuberculosis Infection
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Monica M. Baquero and Brandon L. Plattner
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Mycobacterium avium subspecies paratuberculosis ,γδ T lymphocytes ,WC1 ,macrophages ,monocytes ,dendritic cells ,Immunologic diseases. Allergy ,RC581-607 - Abstract
During early Mycobacterium avium subspecies paratuberculosis (Map) infection, complex interactions occur between the bacteria, cells from the mononuclear phagocyte system (MPS) including both resident (macrophages and dendritic cells) and recruited (monocytes) cells, and other mucosal sentinel cells such as γδ T lymphocytes. Though the details of early host–pathogen interactions in cattle remain largely underexplored, our hypothesis is that these significantly influence development of host immunity and ultimate success or failure of the host to respond to Map infection. The aims of the present study were to first characterize monocyte-derived MPS cells from young calves with respect to their immunophenotype and function. Then, we set out to investigate the effects of WC1+ and WC1neg γδ T lymphocytes on (1) the differentiation of autologous monocytes and (2) the maturation of autologous monocyte-derived dendritic cells (MDDCs). To achieve this, peripheral blood WC1+ or WC1neg γδ T lymphocytes were cocultured with either autologous freshly isolated peripheral blood-derived monocytes or autologous immature MDDCs (iMDDCs). We began by measuring several markers of interest on MPS cells. Useful markers to distinguish monocyte-derived macrophages (MDMs) from MDDCs include CD11b, CD163, and CD172a, which are expressed significantly higher on MDMs compared with MDDCs. Function, but not phenotype, was influenced by WC1neg γδ T lymphocytes: viability of Map harvested from monocytes differentiated in the presence of WC1neg γδ T lymphocytes (dMonWC1neg) was significantly lower compared to MDMs and MDDCs. With respect to DC maturation, we first showed that mature MDDCs (mMDDCs) have significantly higher expression of CD11c, CD80, and CD86 compared with iMDDCs, and the phagocytic capacity of mMDDCs is significantly reduced compared to iMDDCs. We then showed that γδ T lymphocyte subsets induce functional (reduced phagocytosis) but not phenotypic (surface marker expression) iMDDC maturation. These data collectively show that γδ T lymphocytes influence differentiation, maturation, and ultimately the function of monocytes during Map infection, which has significant implications on survival of Map and success of host defense during early Map infection.
- Published
- 2017
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22. Proceso de decisión de desinversión en filiales extranjeras: La experiencia de la industria farmacéutica
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Luis M. Baquero and Teresa Longobardi
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proceso de decisión de desinversión ,relaciones entre empresas matrices y filiales ,operaciones industriales farmacéuticas en puerto rico ,estilos de gestión de subsidiarias. ,Business ,HF5001-6182 - Abstract
Este artículo pretende calcular y analizar los niveles de productividad y de sus componentes para los equipos que participaron en la Liga de Campeones de la UEFA entre 2003 y 2012. Se persiguen tres objetivos: 1) evaluar la utilización de los recursos, 2) analizar los niveles de productividad de los equipos de fútbol y los resultados deportivos y 3) ver si la experiencia que da la participación influye en la productividad y los resultados deportivos. Usando el índice de productividad de Malmquist, los resultados reflejan una ausencia de evolución constante para la eficiencia, la productividad y el cambio técnico. Esta competición no premia el uso eficiente de los recursos y el cambio técnico. Esta competición no premia el uso eficiente de los recursos y no hay una relación concluyente entre productividad y permanencia en la competición.
- Published
- 2014
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23. UN ANÁLISIS SINCRÓNICO DEL VOSEO VERBAL CHILENO Y RIOPLATENSE
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Julia M Baquero Velásquez and Germán F Westphal Montt
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voseo verbal ,Chile ,Río de la Plata ,morfo-fonología ,fonología generativa ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
Se cuestiona el enfoque tradicional de los voseos chileno y rioplatense, el cual deriva ambos de las formas verbales correspondientes a vosotros, usando por lo menos seis reglas distintas, incluidos tres procesos de monoptongación que carecen de toda motivación fonológica. En contrapartida, se argumenta que las formas verbales de dichos voseos no se derivan sincrónicamente de las formas de la segunda persona plural, sino de representaciones subyacentes coincidentes con las de la segunda persona singular no honorífica. Con ello, la teoría requiere del uso de una sola regla especial para el voseo chileno, la cual permite derivar todas las formas verbales del caso, en conjunción con otras reglas que tienen justificación independiente en la lengua. La propuesta se enmarca dentro del formalismo de la fonología generativa clásica. Todas las formas de ambos voseos han sido documentadas en el corpus CORDE de la RAE, el uso de internautas y las intuiciones lingüísticas de los autores.
- Published
- 2014
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24. Clinical stages of patients with Alzheimer disease treated in specialist clinics in Spain. The EACE study
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J. Alom Poveda, M. Baquero, and M. González-Adalid Guerreiro
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: The diagnostic paradigm of Alzheimer's disease (AD) is changing; there is a trend toward diagnosing the disease in its early stages, even before the complete syndrome of dementia is apparent. The clinical stage at which AD is usually diagnosed in our area is unknown. Therefore, the purpose of this study is to describe the clinical stages of AD patients at time of diagnosis. Methods: Multicentre, observational and cross-sectional study. Patients with probable AD according to NINCDS-ARDRA criteria, attended in specialist clinics in Spain, were included in the study. We recorded the symptom onset to evaluation and symptom onset to diagnosis intervals and clinical status of AD (based on MMSE, NPI questionnaire, and CDR scale). Results: Participants in this study included 437 specialists representing all of Spain's autonomous communities and a total of 1707 patients, of whom 1694 were included in the analysis. Mean MMSE score was 17.6 ± 4.8 (95% CI: 17.4–17.9). Moderate cognitive impairment (MMSE between 10 and 20) was detected in 64% of the patients, and severe cognitive impairment (MMSE
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- 2013
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25. Estadio evolutivo de los pacientes con enfermedad de Alzheimer que acuden a la consulta especializada en España. Estudio EACE
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J. Alom Poveda, M. Baquero, and M. González-Adalid Guerreiro
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Resumen: Introducción: Estamos asistiendo a un cambio en el paradigma del diagnóstico de la enfermedad de Alzheimer (EA), de modo que tiende a realizarse en fases más precoces de la evolución, incluso antes de la aparición del síndrome completo de demencia. En nuestro entorno no se conoce en qué situación clínica se está realizando el diagnóstico de la EA. Por ese motivo, se ha llevado a cabo este estudio, para describir el estadio evolutivo de los pacientes con EA en el momento del diagnóstico. Métodos: Estudio multicéntrico, observacional y transversal. Se incluyeron pacientes que cumplían criterios NINCDS-ARDRA de EA probable, atendidos en consultas de Atención Especializada en España. Se recogieron los datos sobre los tiempos asistenciales y de evolución de la EA según el MMSE, el cuestionario NPI y la escala CDR. Resultados: Participaron 437 especialistas de todas las Comunidades Autónomas, que incluyeron un total de 1.707 pacientes, de los cuales 1.694 fueron incluidos en el análisis. La puntuación media del MMSE fue de 17,6 ± 4,8 (IC 95%: 17,4-17,9). El 64% de los pacientes presentaban deterioro cognitivo moderado (MMSE entre 10 y 20) y el 6% grave (MMSE
- Published
- 2013
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26. Identificación, mediante imagen 99mTc-HDP-SPECT/TC, de metástasis pulmonares no conocidas en pacientes con osteosarcoma
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C. Agra Pujol, J. Orcajo Rincón, V. Pérez Aradas, M. Baquero Oliveros, and C. Mata Fernandez
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business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Nuclear medicine - Published
- 2021
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27. Identification, by 99mTc-HDP-SPECT/CT imaging, of unknown pulmonary metastases in patients with osteosarcoma
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C. Agra Pujol, C. Mata Fernandez, J. Orcajo Rincón, M. Baquero Oliveros, and V. Pérez Aradas
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medicine.medical_specialty ,business.industry ,General Engineering ,MEDLINE ,medicine.disease ,medicine ,General Earth and Planetary Sciences ,Osteosarcoma ,In patient ,Identification (biology) ,Radiology ,Ct imaging ,business ,General Environmental Science - Published
- 2021
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28. Influence of the methodological approaches adopted on the food waste generation ratios
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M. Baquero, E. Cifrian, J.R. Viguri, A. Andrés, and Universidad de Cantabria
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Economics and Econometrics ,Food waste generation ratio ,FW measurement ,Food supply chain step ,FW definitions ,Waste Management and Disposal ,European countries - Abstract
Food waste (FW) accounting methodology is of paramount importance in Europe. The European Commission established a common methodology and minimum quality requirements for its measurement. Although these guidelines represents a great advance, important questions as the definition of flows, the Food Supply Chain (FSC) stages considered or the measurement methodology depending on the availability of resources remain open. The study aim is to analyze the implications of these approaches on the FW ratios, based on 109 ratios from different European frameworks obtained by literature review. Among these aspects, the considered FSC stages and the measurement methodology stand out as factors that influence the results; while the direct methods give more accurate values, the indirect methods tend to overestimate the generation. Highlight as significant result, the creation of a superstructure that collects the different approaches used in FW generation ratios and it serves as a tool for benchmarking. This work has been financially supported by the Government of Cantabria R&D project entitled “Obtaining, treatment and dissemination of data related to production and management of waste, and adjustment of the existing indicators system to the valid waste plan of Cantabria”.
- Published
- 2023
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29. Overview of the TCV tokamak experimental programme
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H. Reimerdes, M. Agostini, E. Alessi, S. Alberti, Y. Andrebe, H. Arnichand, J. Balbin, F. Bagnato, M. Baquero-Ruiz, M. Bernert, W. Bin, P. Blanchard, T.C. Blanken, J.A. Boedo, D. Brida, S. Brunner, C. Bogar, O. Bogar, T. Bolzonella, F. Bombarda, F. Bouquey, C. Bowman, D. Brunetti, J. Buermans, H. Bufferand, L. Calacci, Y. Camenen, S. Carli, D. Carnevale, F. Carpanese, F. Causa, J. Cavalier, M. Cavedon, J.A. Cazabonne, J. Cerovsky, R. Chandra, A. Chandrarajan Jayalekshmi, O. Chellaï, P. Chmielewski, D. Choi, G. Ciraolo, I.G.J. Classen, S. Coda, C. Colandrea, A. Dal Molin, P. David, M.R. de Baar, J. Decker, W. Dekeyser, H. de Oliveira, D. Douai, M. Dreval, M.G. Dunne, B.P. Duval, S. Elmore, O. Embreus, F. Eriksson, M. Faitsch, G. Falchetto, M. Farnik, A. Fasoli, N. Fedorczak, F. Felici, O. Février, O. Ficker, A. Fil, M. Fontana, E. Fransson, L. Frassinetti, I. Furno, D.S. Gahle, D. Galassi, K. Galazka, C. Galperti, S. Garavaglia, M. Garcia-Munoz, B. Geiger, M. Giacomin, G. Giruzzi, M. Gobbin, T. Golfinopoulos, T. Goodman, S. Gorno, G. Granucci, J.P. Graves, M. Griener, M. Gruca, T. Gyergyek, R. Haelterman, A. Hakola, W. Han, T. Happel, G. Harrer, J.R. Harrison, S. Henderson, G.M.D. Hogeweij, J.-P. Hogge, M. Hoppe, J. Horacek, Z. Huang, A. Iantchenko, P. Innocente, K. Insulander Björk, C. Ionita-Schrittweiser, H. Isliker, A. Jardin, R.J.E. Jaspers, R. Karimov, A.N. Karpushov, Y. Kazakov, M. Komm, M. Kong, J. Kovacic, O. Krutkin, O. Kudlacek, U. Kumar, R. Kwiatkowski, B. Labit, L. Laguardia, J.T. Lammers, E. Laribi, E. Laszynska, A. Lazaros, O. Linder, B. Linehan, B. Lipschultz, X. Llobet, J. Loizu, T. Lunt, E. Macusova, Y. Marandet, M. Maraschek, G. Marceca, C. Marchetto, S. Marchioni, E.S. Marmar, Y. Martin, L. Martinelli, F. Matos, R. Maurizio, M.-L. Mayoral, D. Mazon, V. Menkovski, A. Merle, G. Merlo, H. Meyer, K. Mikszuta-Michalik, P.A. Molina Cabrera, J. Morales, J.-M. Moret, A. Moro, D. Moulton, H. Muhammed, O. Myatra, D. Mykytchuk, F. Napoli, R.D. Nem, A.H. Nielsen, M. Nocente, S. Nowak, N. Offeddu, J. Olsen, F.P. Orsitto, O. Pan, G. Papp, A. Pau, A. Perek, F. Pesamosca, Y. Peysson, L. Pigatto, C. Piron, M. Poradzinski, L. Porte, T. Pütterich, M. Rabinski, H. Raj, J.J. Rasmussen, G.A. Rattá, T. Ravensbergen, D. Ricci, P. Ricci, N. Rispoli, F. Riva, J.F. Rivero-Rodriguez, M. Salewski, O. Sauter, B.S. Schmidt, R. Schrittweiser, S. Sharapov, U.A. Sheikh, B. Sieglin, M. Silva, A. Smolders, A. Snicker, C. Sozzi, M. Spolaore, A. Stagni, L. Stipani, G. Sun, T. Tala, P. Tamain, K. Tanaka, A. Tema Biwole, D. Terranova, J.L. Terry, D. Testa, C. Theiler, A. Thornton, A. Thrysøe, H. Torreblanca, C.K. Tsui, D. Vaccaro, M. Vallar, M. van Berkel, D. Van Eester, R.J.R. van Kampen, S. Van Mulders, K. Verhaegh, T. Verhaeghe, N. Vianello, F. Villone, E. Viezzer, B. Vincent, I. Voitsekhovitch, N.M.T. Vu, N. Walkden, T. Wauters, H. Weisen, N. Wendler, M. Wensing, F. Widmer, S. Wiesen, M. Wischmeier, T.A. Wijkamp, D. Wünderlich, C. Wüthrich, V. Yanovskiy, J. Zebrowski, the EUROfusion MST1 Team, EUROfusion MST1 Team, Control Systems Technology, Liquid metal heat shields, Science and Technology of Nuclear Fusion, Group Heemels, Mechanical Engineering, Data Mining, EAISI Health, ICMS Affiliated, EAISI High Tech Systems, Applied Physics and Science Education, Reimerdes, H, Agostini, M, Alessi, E, Alberti, S, Andrebe, Y, Arnichand, H, Balbin, J, Bagnato, F, Baquero-Ruiz, M, Bernert, M, Bin, W, Blanchard, P, Blanken, T, Boedo, J, Brida, D, Brunner, S, Bogar, C, Bogar, O, Bolzonella, T, Bombarda, F, Bouquey, F, Bowman, C, Brunetti, D, Buermans, J, Bufferand, H, Calacci, L, Camenen, Y, Carli, S, Carnevale, D, Carpanese, F, Causa, F, Cavalier, J, Cavedon, M, Cazabonne, J, Cerovsky, J, Chandra, R, Chandrarajan Jayalekshmi, A, Chellai, O, Chmielewski, P, Choi, D, Ciraolo, G, Classen, I, Coda, S, Colandrea, C, Dal Molin, A, David, P, De Baar, M, Decker, J, Dekeyser, W, De Oliveira, H, Douai, D, Dreval, M, Dunne, M, Duval, B, Elmore, S, Embreus, O, Eriksson, F, Faitsch, M, Falchetto, G, Farnik, M, Fasoli, A, Fedorczak, N, Felici, F, Fevrier, O, Ficker, O, Fil, A, Fontana, M, Fransson, E, Frassinetti, L, Furno, I, Gahle, D, Galassi, D, Galazka, K, Galperti, C, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Giacomin, M, Giruzzi, G, Gobbin, M, Golfinopoulos, T, Goodman, T, Gorno, S, Granucci, G, Graves, J, Griener, M, Gruca, M, Gyergyek, T, Haelterman, R, Hakola, A, Han, W, Happel, T, Harrer, G, Harrison, J, Henderson, S, Hogeweij, G, Hogge, J, Hoppe, M, Horacek, J, Huang, Z, Iantchenko, A, Innocente, P, Insulander Bjork, K, Ionita-Schrittweiser, C, Isliker, H, Jardin, A, Jaspers, R, Karimov, R, Karpushov, A, Kazakov, Y, Komm, M, Kong, M, Kovacic, J, Krutkin, O, Kudlacek, O, Kumar, U, Kwiatkowski, R, Labit, B, Laguardia, L, Lammers, J, Laribi, E, Laszynska, E, Lazaros, A, Linder, O, Linehan, B, Lipschultz, B, Llobet, X, Loizu, J, Lunt, T, Macusova, E, Marandet, Y, Maraschek, M, Marceca, G, Marchetto, C, Marchioni, S, Marmar, E, Martin, Y, Martinelli, L, Matos, F, Maurizio, R, Mayoral, M, Mazon, D, Menkovski, V, Merle, A, Merlo, G, Meyer, H, Mikszuta-Michalik, K, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Muhammed, H, Myatra, O, Mykytchuk, D, Napoli, F, Nem, R, Nielsen, A, Nocente, M, Nowak, S, Offeddu, N, Olsen, J, Orsitto, F, Pan, O, Papp, G, Pau, A, Perek, A, Pesamosca, F, Peysson, Y, Pigatto, L, Piron, C, Poradzinski, M, Porte, L, Putterich, T, Rabinski, M, Raj, H, Rasmussen, J, Ratta, G, Ravensbergen, T, Ricci, D, Ricci, P, Rispoli, N, Riva, F, Rivero-Rodriguez, J, Salewski, M, Sauter, O, Schmidt, B, Schrittweiser, R, Sharapov, S, Sheikh, U, Sieglin, B, Silva, M, Smolders, A, Snicker, A, Sozzi, C, Spolaore, M, Stagni, A, Stipani, L, Sun, G, Tala, T, Tamain, P, Tanaka, K, Tema Biwole, A, Terranova, D, Terry, J, Testa, D, Theiler, C, Thornton, A, Thrysoe, A, Torreblanca, H, Tsui, C, Vaccaro, D, Vallar, M, Van Berkel, M, Van Eester, D, Van Kampen, R, Van Mulders, S, Verhaegh, K, Verhaeghe, T, Vianello, N, Villone, F, Viezzer, E, Vincent, B, Voitsekhovitch, I, Vu, N, Walkden, N, Wauters, T, Weisen, H, Wendler, N, Wensing, M, Widmer, F, Wiesen, S, Wischmeier, M, Wijkamp, T, Wunderlich, D, Wuthrich, C, Yanovskiy, V, and Zebrowski, J
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Nuclear and High Energy Physics ,Tokamak ,feedback-control ,Nuclear fusion ,TCV ,EUROfusion ,ddc:620 ,plasmas ,Condensed Matter Physics ,tokamak ,nuclear fusion ,QC - Abstract
The tokamak à configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019–20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T e/T i ∼ 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with ‘small’ (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019–20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations.
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- 2022
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30. Validation of edge turbulence codes in a magnetic X-point scenario in TORPEX
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D. Galassi, C. Theiler, T. Body, F. Manke, P. Micheletti, J. Omotani, M. Wiesenberger, M. Baquero-Ruiz, I. Furno, M. Giacomin, E. Laribi, F. Militello, P. Ricci, A. Stegmeir, P. Tamain, H. Bufferand, G. Ciraolo, H. De Oliveira, A. Fasoli, V. Naulin, S. L. Newton, N. Offeddu, D. S. Oliveira, E. Serre, N. Vianello, Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS]Physics [physics] ,Plasma fluctuations ,Plasma dynamics ,[SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,Plasma properties and parameters ,Condensed Matter Physics ,01 natural sciences ,Plasma confinement ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,010305 fluids & plasmas ,Plasma diagnostics ,Fluid flows ,[SPI]Engineering Sciences [physics] ,Electrostatics ,0103 physical sciences ,Transport properties ,Plasma sheaths ,010306 general physics ,Tokamaks ,ComputingMilieux_MISCELLANEOUS - Abstract
Transport processes around the magnetic X-point of tokamaks, such as turbulence and mean-field drifts, are scarcely understood. The assessment of the capability of turbulence codes to quantitatively reproduce these dynamics has been hampered by limitations in computational power and available experimental data. In this paper, we present a rigorous validation of full-scale simulations of a newly developed X-point scenario in the basic toroidal plasma device TORPEX, performed with the four state-of-the-art codes FELTOR, GBS, GRILLIX, and STORM. High-resolution Langmuir probe array measurements of various time-averaged and fluctuating quantities and across the entire cross section of TORPEX show that this X-point scenario features the key ingredients of X-point dynamics, such as small-scale fluctuations and background drifts. The codes are able to qualitatively reproduce some characteristics of the time-averaged fields, such as the ion saturation current profiles at mid-height, the plasma up-down asymmetry, and the blob trajectories. A quantitative agreement is found for the background E × B velocity pattern, while the fluctuation levels are generally underestimated typically by factors of 2 or more, and thus, background fluxes are found to dominate over turbulent ones in simulations. The sensitivity of the simulation results on the plasma collisionality and on the position of the sources is tested in GBS, showing a mild effect on the overall quantitative agreement with the experiment. Overall, this validation reveals the challenges to reproduce the plasma dynamics near an X-point and provides a clear path to a quantitative and computationally relatively inexpensive assessment of future developments in turbulence codes.
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- 2022
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31. Methodology proposed for estimating biowaste generation using municipal rurality indexes
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Ana Andrés, L. Pérez-Gandarillas, Eva Cifrian, M. Baquero, and Universidad de Cantabria
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Estimation ,Consumption (economics) ,Rurality ,Environmental Engineering ,Renewable Energy, Sustainability and the Environment ,Biowaste ,Municipal level ,Waste generation ,Food waste ,Statistics ,Environmental science ,Multiple linear regression analysis ,Waste Management and Disposal ,Municipal solid waste management ,Regression analysis - Abstract
The separated collection and management of biowaste (BW) must be implemented in next years in the European countries. In order to define a proper BW strategy, it is necessary to estimate the generation at a municipal level, since depending on the amount to be treated, the strategy may notably vary. The aim of this study is to develop a methodology to estimate BW generation at municipal level taking into account the characteristics of the region, the Municipal Solid Waste management applied, and diferent socio-economic variables that defne the level of rurality of a municipality. A model to estimate the BW generation for each type of municipality has been developed using Multiple Linear Regression Analysis. As input data, results from a Waste Compositional Analysis executed by the regional government to samples collected on 38 municipalities and data related to infuential socio-economic variables have been used. Signifcant infuence of socio-economic variables on BW generation is observed for the rural municipalities. The evolution of these characteristics, as well as the greater awareness of society with food waste, have change the consumption patterns. Therefore, it is not recommended to use static ratios, but models that allow including socio-economic changes in the estimation of waste generation. This work has been financially supported by the Government of Cantabria R&D project entitled “Obtention, treatment and dissemination of data related to production and management of waste, and adjustment of the existing indicators system to the valid waste plan of Cantabria”. The public company MARE S.A. has provided the MSW generation data, as well as the WCA characterisations used to develop the statistical modelling
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- 2022
32. Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease
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I. Ferrer-Cairols, L. Ferré-González, G. García-Lluch, C. Peña-Bautista, L. Álvarez-Sánchez, M. Baquero, and C. Cháfer-Pericás
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Neuropsychology and Physiological Psychology ,General Neuroscience - Published
- 2023
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33. A false-positive case on brain 18F-Choline PET/MR due to tumefactive multiple sclerosis. A case report
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J.R. Garcia, M. Baquero, P. Bassa, A. Compte, S. Mourelo, and E. Riera
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General Engineering ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
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34. Falso positivo por esclerosis tumefacta en PET/RM cerebral con 18F-Colina. A propósito de un caso
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S. Mourelo, E. Riera, Pere Bassa, M. Baquero, A. Compte, and J.R. Garcia
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Pathology ,medicine.medical_specialty ,Tumefactive multiple sclerosis ,Text mining ,business.industry ,Choline pet ,medicine ,MEDLINE ,Radiology, Nuclear Medicine and imaging ,medicine.disease ,business - Published
- 2022
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35. Thermal, electromagnetic and structural analysis of gas baffles for the TCV divertor upgrade
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G. Calabrò, M. Baquero, S. Minucci, Dario Vaccaro, A. Salvitti, J-M Moret, B. P. Duval, D. Marzullo, H. Elaian, Pierluigi Fanelli, Christian Theiler, H. Reimerdes, M. Toussaint, G. Di Gironimo, Vaccaro, Dario, Elaian, H., Reimerdes, H., Baquero, M., Duval, B. P., Marzullo, D., Moret, J. -M., Theiler, C., Calabrò, G., Di Gironimo, G., Fanelli, P., Minucci, S., Salvitti, A., and Toussaint, M.
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Tokamak ,Materials science ,Nuclear engineering ,Finite element analysi ,Baffle ,Fixture ,7. Clean energy ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Divertor ,law ,0103 physical sciences ,Thermal ,General Materials Science ,010306 general physics ,Finite element analysis ,Plasma facing components ,TCV ,Civil and Structural Engineering ,Nuclear Energy and Engineering ,Materials Science (all) ,Mechanical Engineering ,Plasma facing component ,Closure (computer programming) ,Plasma channel ,Current (fluid) - Abstract
As part of an ongoing divertor upgrade of the TCV tokamak it is planned to add gas baffles to form a divertor chamber of variable closure. The baffles promise to increase the compression of neutral particles in the divertor and, thereby, extend the research on the TCV divertor towards more reactor relevant, highly dissipative divertor regimes. It is foreseen to construct the baffles entirely of polycrystalline graphite that was used for the existing TCV protection tiles. The thermal considerations of the baffle design are based on the heat loads expected during normal operation, where even an extremely large increase in the power carrying plasma channel towards the baffle over the entire 2 seconds duration of a TCV discharge gives no cause for concern. An electromagnetic analysis considers halo currents flowing through the baffles, which can occur during disruptions, as a worst-case scenario. It is found that a halo current of 250 kA results in an average vertical force in the baffles of up to 950 kN/m3. The fixture of the baffle tiles to the vacuum vessel is designed for a maximum tensile stress of 31 MPa and maximum compressive stress of 60 MPa that remains a factor of two below their respective material limits. The obtained results of the thermal, electromagnetic and structural analysis thus validate the proposed baffle design.
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- 2019
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36. Papel de las colecciones de piezas anatómicas en la enseñanza de la anatomía patológica
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M. Baquero, Lourdes Mariño Gutiérrez, and María Antonia Meseguer
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010404 medicinal & biomolecular chemistry ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,01 natural sciences ,0104 chemical sciences ,Pathology and Forensic Medicine - Abstract
Resumen La trascendencia de la museologia relacionada con la anatomia y la anatomia patologica radica tanto en la conservacion de piezas anatomicas naturales o de sus reproducciones, como en la posibilidad de ofrecer un valioso material para fines didacticos e investigadores. Los primeros fundamentos para la ensenanza anatomica fueron los theatrum anatomicum y los «gabinetes anatomicos» de las catedras de anatomia de la facultades de medicina europeas, a los que sucedieron en siglos posteriores los museos anatomicos y anatomopatologicos. Tras una epoca de auge durante el siglo xviii , la mayor parte de ellos sufrieron un proceso de decadencia progresiva que llevo a la perdida de muchos de ellos. En la actualidad se observa un interes creciente en la recuperacion y puesta en valor de estas colecciones. Este trabajo muestra una aproximacion historica de su desarrollo y una revision de la situacion actual de los principales museos de Espana y de Europa.
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- 2019
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37. Identification, by
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J, Orcajo Rincón, M, Baquero Oliveros, C, Mata Fernandez, V, Pérez Aradas, and C, Agra Pujol
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Osteosarcoma ,Lung Neoplasms ,Single Photon Emission Computed Tomography Computed Tomography ,Humans ,Bone Neoplasms - Published
- 2021
38. Effects of inflammatory stimuli on responses of macrophages to Mycoplasma bovis infection
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Jeff L. Caswell, Jose Perez-Casal, Cassidy Wong, DeLenn Burrows, Meghan Domony, Hugh Y. Cai, Ksenia Vulikh, Monica M. Baquero, and David Marom
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Mycoplasma bovis ,Proteases ,Priming (immunology) ,Cattle Diseases ,Inflammation ,Biology ,Microbiology ,Cathepsin B ,medicine ,Animals ,Secretion ,Mycoplasma Infections ,Phospholipases A2, Secretory ,Lung ,General Veterinary ,Macrophages ,General Medicine ,Pneumonia ,medicine.disease ,medicine.anatomical_structure ,Cytokines ,Cattle ,medicine.symptom ,Pneumonia (non-human) ,Respiratory tract - Abstract
Inflammation in the respiratory tract is thought to worsen the disease response to Mycoplasma bovis infection. This study investigated the cells involved in this response with a focus on proteases and cytokines as harmful effector mechanisms. By immunohistochemistry, Mac387-positive macrophages were the main cell type comprising the foci of caseous necrosis in cattle with M. bovis pneumonia. Thus, the study evaluated how priming of different types of macrophages with bacterial lysate (or pro-inflammatory cytokines induced by the bacterial lysate) affected their responses to M. bovis infection. Inducible responses were detected in monocyte-derived macrophages (M1-MDMs and M2-MDMs), whereas pulmonary alveolar macrophages (PAMs) were minimally affected by priming or infection. M. bovis-infected MDMs secreted MMP-12 and SPLA2, and priming with pro-inflammatory cytokines increased the secretion of cathepsin B in response to M. bovis infection. Of these, there were higher concentrations of cathepsin B and SPLA2 in lungs with M. bovis pneumonia compared to healthy lungs, and these are potential mechanisms for macrophage-induced lung damage in M. bovis infection. Priming of MDMs with either bacterial lysate or with pro-inflammatory cytokines caused an enhanced response to M. bovis infection with respect to IL-8 and IL-1β secretion. The findings of this study suggest proteases, lipases and cytokines derived from monocyte-derived macrophages as possible mediators by which prior inflammation in the respiratory tract worsen disease outcomes from M. bovis infection.
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- 2021
39. Rapid desensitization in patients with hypersensitivity to acetylsalicylic acid with indication for dual antiplatelet therapy due to coronary artery disease. A guide for the clinician in the intensive care unit
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Javier M. Baquero, Andrés F. Buitrago, Edgar Celis, Manuel José Álvarez, and Dormar David Barrios
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Ácido acetilsalicílico ,Enfermedad arterial coronaria ,Acetylsalicylic acid ,Infarto agudo del miocardio ,Acute myocardial infarction ,Cardiology and Cardiovascular Medicine ,Coronary artery disease - Abstract
Resumen El ácido acetilsalicílico (Aspirina) es un inhibidor irreversible de la acetil ciclooxigenasa (COX) y su actividad no es restaurada hasta la formación de nuevas plaquetas. Sus efectos benéficos terapéuticos cardiovasculares lo han convertido en la piedra angular del tratamiento del paciente con enfermedad arterial coronaria. Existe una población de pacientes con indicación absoluta para su uso; sin embargo, la presencia o antecedente de hipersensibilidad a esta molécula conlleva un alto riesgo de complicaciones no relacionadas con enfermedad cardiovascular. En algunos de estos pacientes es crucial conocer e implementar protocolos de desensibilización para el ácido acetilsalicílico y, de esta manera, continuar con el uso de esta estrategia terapéutica necesaria e idónea en esta población. Abstract Acetylsalicylic acid (Aspirin) is an irreversible inhibitor of acetyl cyclooxygenase (COX) and its activity is not restored until new platelets are formed. Its beneficial therapeutic cardiovascular effects have made it the cornerstone of the treatment of patients with coronary artery disease. There is a population of patients with absolute indication for its use, however, the presence or history of hypersensitivity to this molecule leads to a high risk of complications unrelated to their cardiovascular disease. It is vital to know and implement in some of these patients, desensitization protocols for acetyl salicylic acid and in this way to continue the use of this therapeutic strategy necessary and appropriate in this population.
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- 2021
40. Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities
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H Appeltants, C Boesch, I Cromarty, D Carretta, S Romanov, U Windstetter, F Mibach, Jens Refsgaard, S Lebedev, F Proietti, M Y Tamimi, M C Gamboa, M Novikova, E Prada, K H Sim, E Messas, E Zherlitsyna, A Kalampalikis, N Nevolina, N Trocan, J Cohen, G Szto, R Gilabert Gómez, M Omelchenko, A Pinzani, D Goodwin, J Umaran Sánchez, Kim Fox, S H Dong, K Kronberg, E Castillo Lueña, T Ignatieva, S Joubert, C Macchi, S Lee, S Eidelman, F Alizon, S Chandra, M Akbar, D M Colquhoun, G Yanes Bowden, J de Juan Baguda, M Sebastian, C Wernham, K Miedema, R La Greca, C Morton, B S Jheeta, A C Tran, T Q Do, O Rodrigues, J Yan, S H Kim, R Jurgaitienė, Jean-Claude Tardif, R Baleón, D Hay, V Hennebelle, F Fazekas, R Davies, P Gratia, L Sorodoc, S Y Wu, C Martínez Sánchez, L Lopes Antunes, T H T Pham, I Suliman, M J Gómez Martinez, A Pernat, S H Hur, M Alanazy, L Zhabina, M Stanley, J Rogers, Y J Kim, S Geffroy, L K Andersen, S Coman, V Pedrosa del Moral, Y Garaud, J Krupicka, O Dzhkha, C Paul, M Jeżewska, B Mahler Mioto, V Abduvalieva, P Morra, L Kucheryava, C La Rosa, B Chan, M Wrębiak-Trznadel, A Kozlowski, M Sharif, L López Barreiro, V Kolesnikov, M Lawrence, A Tucker, C Okawabata, B La Hay, E Sadauskienė, B K Nguyen, L Bui, A Said, M E Ruíz Esparza, R K Saran, M S C Ho, E Homs Espinach, J R Romo Santana, J Forte De Carvalho, I Pattison, H H Phan, L Baleeva, L Kisiel, A López Granados, C Raters, F Paganelli, R Haberl, A P T Wong, D Xu, R Jagathesan, L Grekhova, H Stursova, Q B Truong, P Raymond, Y Sosnova, N H Khong, J Zarauza Navarro, C Florescu, L Gorshkova, N Saaidin, E Gordillo Higuero, L Davin, I Budanova, C Lavicka, L Gruznykh, P Bogdański, A Dufka, I Arroja, H A R Tahir, G Wilson, G Kolios, S J Yoon, Simon Cattan, K Berdnik, A Serrano, B Sievers, A Rodríguez Almodóvar, L A Holden, F O'Reilly, D Verleyen, H Hafez, K Nehrig, S M Kang, S Berrisch-Rahmel, E Meyer-Michael, P Samama, L Soares, A K Nguyen, F Tuktarova, C Weytjens, E Sandoval Rodriguez, J Cheng, F M Villasenor, João Morais, B Sullivan, R Zimoląg, Albert V. 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Velez Edwards, A Buakhamsri, N Bazargani, U Spengler, M Toringhibel, M A Matos, I Skoczylas, V Arrarte Esteban, J Fuertes Beneitez, V Gil, L U P Tran, A Mehta, A Álvarez Sangabriel, P Di Pasquale, K Egstrup, P Choudhury, S Whetstone, T S Chee, M Elkohen, P Martina, J Martínez Rivero, C Arden, J Walczewska, I Benett, R Silvestri, V García Saavedra, J Słaboszewska, A Thomson, S Revienė, A Szpak, V Challenor, F Saporito, P Ruiz Pérez, Vives, H M Li, I Sadykova, D Lawton, T Kuzmina, R Elias, D Troup, P Dehayes, J Vavougios, V Pernice, P Tanielian, R Cabrera Solé, T Pitsch, R Nethononda, P Poinson, A Tavares E Taveira, J Yi-MingCha, J Y Hwang, T Haghfelt, C García Pindado, N Bilous, A Kotsalos, M Bariaud, A Drzewiecka, L Polkina, V Arfaras, P Vymetal, J Rawal, A Aumjaud, H P Wang, L Wu Amen, J Fernandes, F Howie, A Ouguoujil, M H Ngo, J A Bertarini, A Malysheva, G De Geeter, N Aimouch, R Parkin, H Taylor, M Kittipovanonth, A Gupte, S Ramanaidu, L Basto, A Zherebtsova, T Arsentieva, V Männl, Y L Cham, J J Gómez Doblas, D Ennouchi, Iveta Mintale, A Vance, R Jirmar, L Boikova, D T Le, P Srivastava, L Tonet, M Liautard, C Proto, Q H Do, Mª A Pérez Martínez, R Stankevičius, L Semedo, M Anghel, I Nikolaeva, J Janes, H Al-Backer, M C Escourrou Berdou, O Leshchuk, D Reshotko, V P Dang, I Édes, L Schlueter, B Sikorska-Buczkowska, K Hatalova, I Marozsán, S Gessner, J Gmehling, M Kuzmicheva, Z Huang, L Kosareva, D K Kumbla, A Baika, F El-Shaer, T Voronova, J M Chopo Alcubilla, A Veternik, S Mohr, D Garcia, J Y Rhew, C K Yeo, C De Niel, H K N Nguyen, E Orts Soler, J Dubrava, S Natarajan, M S H Khan, U Kossowska, J P Detienne, T T H Nguyen, I Centa, M G Millauer, Jose Lopez-Sendon, J T Counsell, E Galehr, T Schröder, L Frost, P P Singh, C Moya López, R Beyer, L Carpentier, J Carrillo Calvillo, Z M Du, R Steeds, E Horstkotte, P Kindler, P Johnson, M Sander, I Rodríguez Tejero, F Azar Manzur, S Brown, M Odín de los Ríos Ibarra, C K Choor, M A Sadiq, D B Gysan, V B Doan, A Gueusquin, M Andrews, L L Feng, B Martina-Hooi, S R Shetty, Y Dascotte, E T Ch'ng, P Dematteo, A Woodall, S Gabriilidis, Jean Ferrières, S K Oh, J Lindford, S Blignaut, L Macedo, R Carrillo Cardoso, Y C Lai, C Lang, S R Jayasinghe, B Bastian, V Sanfins, J de Jeús Zuñiga, F X Meriaux, G Sepp, S Molotyagina, S García Ortego, T Perger, Y Lukina, J H Wirtz, A Regulska, P Durand, P Loheac, J Sinnadurai, S Avlonitis, J García-Moll Marimón, J Bradley, K Pareathumby, L Latyntseva, D Stergiou, K Ling, S K Hong, N S Chonkar, C Goldie, C C Koo, A Salustri, Y Peneva, I Rodríguez Briones, P Ferreira, L Franskyavichene, G Bragança, C Rodrigues, S H Lee, L Dang, B J Lubelsky, L Weinrich, E Hoffer, J Tricoire, M Marachli, O Smirnova, C Falces Salvador, A Mobeirek, M Fagan, A Serazhim, M M W Yeung, F Petitjean, I Cullen, J Benacka, Yañez Wonenburger, D Gentille Lorente, J Ferreira Dos Santos, F Bosa Ojeda, N Marchionni, L Brottier, P Keelan, D Kerö, L Moretti, R Seabra Gomes, I Jasinkevica, P Purnode, D Relange, H N Luqman, A Petit, I Hamilton-Craig, E Kochurov, P Berry, P Aguar Carrascosa, M Noble, S Yvorra, N Razzaq, J M Walch, L Lenartowska, R Sethi, W Kim, C Killeen, S Kurochkina, N Capuano, P Sampson, K H Mak, T Bouchaya, J Hellermann, M Geneves, F Ramos Ariznabarreta, J L Mougeolle, J Ferreira, T Roy, J de Andrés Novales, J F Monteiro Ferreira, M S Mayer, N Lopez Cabanillas, P Touzet, K H Ng, F Pelier, T K Huynh, J Schindler, T Krechunova, A Gaglione, Z Fras, P Haralambus, R Pradhan, L P Low, G Odent, M Sidor, R Sopia, D Janody, T K Ong, K Adamaszek, G Vives Boniato, T Maxwell, H Charles, D Gough, O Dibon, A A Abdul Rahim, H B Liew, S Tikhonova, I Bläse, J Chambel De Aguiar, E Santas Olmeda, M Rosseel, R Angela, D Savard, C Cernetti, O Huttin, J Calder, O Kilaberiya, A Elkrail, I I Tulevski, A Ilyukhina, E Chalkiadakis, R Antonicelli, H C Gwon, G Bautista López, G Brown, J Kojelienė, R Zeitouni, J Mimoso, N Better, N H Vu, H Abdel Wahab, B Poprawa, F Weber, A Ghicu, K Rybak, G Fouquet, C Pindado Rodríguez, A Salakhova, L Isaeva, M H Fallacher, J Placke, G McCansh, V D Tran, O Gusev, D Enayat, P Khera, E Brice, G Levesque, A Alvarez Auñon, M A Arnau, M A López Aranda, E Andreicheva, I Kruck, R Grigoriu, I Sainz Hidalgo, M Węglarz, A Ajani, I Khudina, T Makhieva, V D Dang, R Testa, E Cisowska-Drozd, F Giacomazzi, R Cierpka, Nicola Greenlaw, P Wong, L Simões, L Tsaryabina, O Gureeva, R Raffelsberger, H Luquez, A Rainbird, D Evéquoz, M A Balice-Pasquinelli, R Massay, K L Joseph, I H Chae, R Herrmann, I Salecker, A Montero Gaspar, P F Fonseca, A Martin, W Czarnecki, R Motomancea, E Dechoux, M Shamsuzzaman, M Leandri, D Marzal Martín, C Navas Navas, C Beaurain, T Gkinis, K Shetty, P A Jeannerat, D S Wong, A Gonzaga, W Kulig, J F Millet, E Jankauskienė, E Anastasiou, A I Ruhani, N Aksyutina, O Kolesova, K Yared, M Panajatovic, Y L Zhou, S Thurston, T Alekseeva, S Preston, N Mai, M Kuzyakina, D Rechtman, T Boonyasirinant, J Nobre Dos santos, A Ahuad Guerrero, M Al-Shamiri, M Feldner-Busztin, S Godart, S Liandrat, A Narayan, L Burlakova, M J García Martínez, C Militaru, J Chávez Paez, H B Matheson, D Meddah, P Brindle, N Petrova, A Nicolino, D Spensieri, A Giuca, E Molina Laborda, J Moreno Arribas, V Martinho, T Mularek-Kubzdela, S K Chua, G A Dan, N T H Tu, V T Nguyen, M Alcocer Gamba, J Costa, H Milligan, R Badr-Eslam, E Variava, A Merkhi, C Mays, R De Castro Aritmendiz, A K Mohamed Yusof, A Hamer, R McNeilly, S Dedkova, D Rousson, K Chamou, A Mahr, D C Dan, R Till, T L Yang, M Vida Gutiérrez, D Piyayotai, É Bajcsi, D Zaronskienė, I Alexopoulos, Y Huo, H S Zeng, P Rowe, S Fleming, D B Vu, Á Dongó, C Hand, J C S Leong, M Claeys, S Hood, J Bozkova, G Vieyra, G Unger, A Liqui-Lung, D Cremer Luengo, M Castillo Orive, S Muth, M Joseph, P L Torres Díaz, C Zakopoulos, D Cross, F Trujillo Berraquero, F Sattar, H A Boyrazian, T B Le, M Mantcheva, M Constantinescu, P Gosse, U Keil, G F Vaz, M Bdeir, T S Pham, M J García González, J K Ryu, D W Jeon, Zs Malkócs, J Á Perea Egido, R Izquierdo González, V Probst, E Wellenkamp, C Boureux, M Czarnecka, C Vaughan, H Falconer, H Brunner, G Peña Pérez, E Nelböck-Huber, E Blanc, F Thomas-Richard, A L R Ng, M Provvidenza, R Gascueña Rubia, J Freitas, A Dabboura, B Mörz-Proszowski, A Utech, C Alves, C M David, J A Lastra Galán, L Oliveira, T A Nguyen, I Ghaly, A Hofmeister, I Gorodilova, P Szałkowski, M S Hiremath, G Golovina, C Daly, M Tardy, S Kostomarova, J-P Salembier, P Zagožen, D Wang, M Vogel, J Borbola, I Chlewicka, K-H Schmitz, C Pappas, J Victory, M Garandeau, P Wiggers, C Piñero Ramírez, L Tkhorzhevskaya, E Suglobova, V Samakhovets, P Surmont, H A Ramírez Reyes, M Winter, F Prunier, B Cavert, B Salaun, J M Roca Catalán, A Beinhauer, Ian Ford, K Elsby, V Knyazeva, C Tamburino, V Khoury, A Felice Castro Issa, B Marchenko, K König, A Kennedy, J M Alegret Colomer, T Gillet, Clarify Investigators, B Maheu, A Troncoso Gil, N Haldane, B Koujan, T Mouhat, A Waldman, J Robert, J Campbell, A Kokis, M Micheals, P Gori, P Ramoutar, M Al Zaibag, V Ryzhkova, M Kazakovtseva, C Bernardeau, B Ferreiro Rodríguez, Y Voloshko, S Szabo, I Jarvis, Y N Ke, J Donetti, A Serrano-Garcia, R Ketelers, S Grigoryan, V Kulik, P Zündorf, L Kleemann, J McPherson, M Luaces Méndez, F Mouquet, L G Xiong, T H Tran, P Costello, A Potter, M Cinteza, F Colivicchi, E Nowicka, O Greiner, G Reddy, M Martins Oliveira, F Fernandes De Sousa, P Nocon, R Sewell, I Nikodemska, R Tadeu Munhoz, T Gilbert, I Laizane, M Maroun, B Demianiuk, A Bolidai, R Kacorzyk, R Fernández Mouzo, K Karastanev, J Blanco Castiñeiras, P Messali, R Schwarz, M Vardhani, O Gouli, C Thelemann, A Forclaz, G Khaznadar, G Eisele, P Sosner, M L Bourachot, N Pontikakis, S Heinemann-Meerz, E Zatsarina, E Smrckova, P Calmettes, D H Kang, M L Santos Iglesias, S M Marinescu, A Heap, Melnikova, N F Strathmore, S Tolpygina, M Yang, M Naisseh, E George, J Banach, E Delcoulx, E Teijeira Fernández, J Poles, P Saunders, S Haddad, T Q Luu, A Dhesi, O Prikolota, M Baar, P Lafontaine, C O'Dong, I Petropoulos, B-M Altevogt, D Warden, T De Backer, G Miñana Escrivá, T L Mai, U Schlesinger-Irsch, M M Gomaa, E Moksyuta, M Drexler, P Monteiro, P Grooterhorst, J Moolman, P McAlavey, J O'Shea, L P Quinn, F Crespo, K Srinivasa Reddy, T Shokina, Ellen M. Schmidt, M H Jeong, K Denef, A Pleskof, I Takács, Y Tikhonov, O Ushakov, L Stevens, J Ezcurdia Sasieta, L Nkombua, O Henne Otero, J Y Fraboulet, D S Kim, G Hoh, A Tamm, M Sardon, G Chatzioakim, M A Ulecia Martínez, S Reymond, M Myint, G Proença, R Massabie, E Foster, H Dougall, Anjan Kumar Roy, C Franco Aranda, M Getman, E Filippova, C Aguiar, X D Pu, N Voronina, L L Chen, M Szulc, L Bayakhchan, M J Pinto Vaz, C Niederberger, N Vites, I Sen, Paul R. Kalra, J A Castillo Moreno, W K Ng, C Brunschwig, D Morgan, A Concepción Clemente, N Yakimova, J M Guy, A H Jaafar, J Badarienė, N Taylor, L Compson, R Amor, A Maximovitch, J L Bardají Mayor, E Marín Araez, N H Chau, N Srtumilenko, K Kelly, A Papathanasioy, S Erofeev, B Mamez, A Ribeiro, M Micko, N Alvarenga Recalde, K Atueva, Z Sebõk, P Kycina, A K Gupta, A Laucevičius, R Ahuja, A Prokop, P Stadler, S De Ridder, L Zhang, F B Ramadan, L Kapustina, V Fedoskin, A Bateman, C A Nacht, R Musetescu, M Aparici Feal, A Büttl, S Ross, M Rau, P Federico Zaragoza, G Brisson, M Zagreanu, T T H Pham, F Dominé, N Davydova, N Petrochenko, N Paul, P H Truong, S Frickel, W Bryl, G Brouillette, A Stumpp, M Barrera Bustillos, C Ziccarelli, O Zalyzniak, M eatherhead, N Watkins, G Riccioni, l Kudryavtsev, R Carvalho, J P S Sawhney, V González Toda, P Matos Dias, M Giorgadze, I Rodriguez Marrero, W Gritsch, K Lee, G W Kellam, I Parker, V Ecina, Mª I Soto Ruiz, C Delhomme, T Ivaschenko, Y W Cheah, I Grudtsina, R Chehayeb, T Dookie, O Krasnoslobodskaya, P Jarmużek, F Van den Branden, A M F Vandeplas, A Rocha De Almeida, M Espiga De Macedo, E Łotocka, K Nagy, R Paliulionienė, J L Leyva Pons, N Fedorova, Y Yanina, O Stasuk, Z Vlasuk, P Lim, P Egloff, T Berezhna, A Faria, J Cerda Rojas, E Moser, H G Jin, S J Oh, G Arquero García, K H Karner, I Leontaridis, A Banikova, J Fridrich, H Lesseliers, I Pokrovskaya, P Astridge, H Abdul Manap, R Daniel, C A Almeida Fernández, A Nowowiejska-Wiewióra, B Carvalho De Moura, M Malden, H Rosenstein, S Dixon, G Balogh, M Adam-Blanpain, A Sandalian, H Gervas Pavón, G A Antoniadis, N Naberezhnova, A Amlaiky, P Terrosu, K K H Lau, B Chartier, X Su, O Kovyrshyna, G Beale, P Primot, M H Chen, S S Ramesh, R Chyrek, E Gómez Álvarez, J Rodríguez Collado, G Sibilio, R Jeremiasz, R Colin, C Lalla, G M Fullerton, M P Samal, H Thümmel, R P Patel, J Takhar, H M Kwon, T A Cieza Lara, F Magliari, J Morrell, M Rayo Gutiérrez, T L Orenstein-Lyall, H Choi, S Kulinich, A Aftab, A Wallace, B B Abdul Kareem, S Kwok, A Królak, A Grover, Laurent Fauchier, Mª J Pinilla Lozano, G Sengupta, D Paris, M Al Dhanki, J Milewski, F Petersen Aranguren, H Brufau Redondo, H Mayr, A Arias Mendoza, M Ducoudre, A Correia, J S Awtar Singh, P Aylward, E Brscic, J Du Plooy, J L Arenas León, G Silva Alves, L Sreenivasa Murthy, P Dendale, F La Varra, S Minkin, T Eggeling, A Jamiel, G Lebischak, E Andreev, T V A Tuong, V Chaithiraphan, O Duprez, S Higgins, F Chometon, Y Cottin, A Bonny, C Guyetand, J Matos, F Henpin Yue Cesena, L Polyaeva, M Drijfhout, J Toplak, G E Vertes, N F Wang, J Doucet, A K Trivedi, P Turek, G Chouinard, A Al Lawati, W Filip, F Kovar, T J Cha, A Belanger, H L Cong, J F Robert, D López Gómez, J L Sanz Rodríguez, H Simper, P Shetty, A Chukwu, E Bukanina, C Amoros Galito, H MacCowan, T T T Tran, A Singal, K C Vu, O Ismail, A Ardiaca Capell, P Bousquet, F Goss, Z Galeeva, Maxime Guenoun, B Rijavec, Z Lazerevic, A McCracken, A C Motoc, Y Sharapova, S Wright, A J Paule Sánchez, L Mainar Latorre, I Sirazov, X L Yang, S E Paget, G Berkenboom, J Markenvard, I Surovtseva, S K George, Matthias Simon, M L Fuantos Delgado, C Christoforidis, M Lagares Carballo, P Alvarez García, J Könemann, L Crawford, I Gonos, D Saulnier, E Szabó, L Ardouin, J Bhayat, F J Abardía Oliva, X Bernard, O Sirbu, P Boutsikos, N Khmelevskikh, E Tavlueva, P LeBouthillier, I Bourazanis, A Sequeira, M López Martínez, C P Paulus, R K M Bhaskaran, F Pellerin, B Brown, B Saleh, A Lacchè, R Sola Casado, E Kaźmierczak, M Weingrod, and G Vijayaraghavan
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medicine.medical_specialty ,Cardiac & Cardiovascular Systems ,Epidemiology ,LONG-TERM ,medicine.medical_treatment ,Chronic coronary syndromes ,Coronary Artery Disease ,Revascularization ,Ventricular Function, Left ,GLUCOSE ,MELLITUS ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Ethnicity ,Prevalence ,medicine ,Humans ,ARTERY-DISEASE ,Myocardial infarction ,Stroke ,RISK ,OUTCOMES ,Ejection fraction ,Science & Technology ,business.industry ,Proportional hazards model ,CLARIFY Investigators ,Hazard ratio ,Diabetes ,Stroke Volume ,Geographical disparities ,Syndrome ,medicine.disease ,MIDDLE-EAST ,EUROPEAN-SOCIETY ,Treatment Outcome ,MYOCARDIAL-INFARCTION ,Heart failure ,CLARIFY registry ,Cardiovascular System & Cardiology ,HEART-FAILURE ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine - Abstract
BackgroundIn contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity.Methods and resultsCLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure.Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest.ConclusionIn patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.ClinicalTrials identifierISRCTN43070564
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- 2021
41. Inline Combline Filters of Order N With up to N+1 Transmission Zeros
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David Rubio, Santiago Cogollos, Vicente E. Boria, Miguel Angel Fuentes, Marco Guglielmi, M. Baquero, and Jose Joaquin Vague
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Radiation ,Admittance ,Computer science ,Capacitive sensing ,Order (ring theory) ,Mixed couplings ,Condensed Matter Physics ,Topology ,Inductor ,Transmission zeros (TZs) ,Resonator ,Filter (video) ,TEORIA DE LA SEÑAL Y COMUNICACIONES ,Equivalent circuit ,Combline filters ,Electrical and Electronic Engineering ,High selectivity ,Passband - Abstract
[EN] In this paper we describe several alternative inline implementations for combline filters with transmission zeros located both below and above the pass-band. A systematic design procedure is also presented using a lumped-element equivalent circuit. Following the design procedure that we propose, up to N+1 transmission zeros can be implemented with an inline filter of order N. The generation of the transmission zeros is explained physically in terms of mixed inductive and capacitive couplings. Several filters are also manufactured and tested. Good agreement between measured and simulated results is demonstrated thereby fully validating the new filter concepts., This work was supported by the Ministerio de Ciencia e Innovacion under Coordinated Project PID2019-103982RB-C41.
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- 2021
42. Initial TCV operation with a baffled divertor
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H. Reimerdes, B.P. Duval, H. Elaian, A. Fasoli, O. Février, C. Theiler, F. Bagnato, M. Baquero-Ruiz, P. Blanchard, D. Brida, C. Colandrea, H. De Oliveira, D. Galassi, S. Gorno, S. Henderson, M. Komm, B. Linehan, L. Martinelli, R. Maurizio, J.-M. Moret, A. Perek, H. Raj, U. Sheikh, D. Testa, M. Toussaint, C.K. Tsui, M. Wensing, the TCV team, the EUROfusion MST1 team, Science and Technology of Nuclear Fusion, TCV Team, and EUROfusion MST1 Team
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Coupling ,Nuclear and High Energy Physics ,Tokamak ,Materials science ,Nuclear engineering ,Divertor ,Baffle ,Plasma ,Condensed Matter Physics ,01 natural sciences ,TCV tokamak ,010305 fluids & plasmas ,law.invention ,law ,0103 physical sciences ,Tokamak à configuration variable ,Plasma exhaust ,010306 general physics ,Plasma density - Abstract
The Tokamak à Configuration Variable (TCV) tokamak is in the midst of an upgrade to further its capability to investigate conventional and alternative divertor configurations. To that end, modular and removable gas baffles have been installed to decrease the coupling between the divertor and the plasma core. The baffles primarily seek to suppress the transit of recycling neutrals to closed flux surfaces. A first experimental campaign with the gas baffles has shown that the baffled divertor remains compatible with a wide range of configurations including snowflake and super-X divertors. Plasma density ramp experiments reveal an increase of the neutral pressure in the divertor by up to a factor ×5 compared to the unbaffled divertor and thereby qualitatively confirm simulations with the SOLPS-ITER code that were used to guide the baffle design. Together with a range of new and upgraded divertor diagnostics, the baffled TCV divertor is now used to validate divertor models for ITER and next step devices with particular emphasis on geometric variations.
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- 2021
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43. Toxocariasis y vacunación para Toxocara: una revisión sistemática
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Mónica M. Baquero-Parra, Carina da Silva-Pinheiro, Neuza Maria Alcantara-Neves, Dumar A. Jaramillo-Hernández, and Luis F. Salazar-Garcés
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030231 tropical medicine ,Toxocariasis ,medicine ,Biology ,medicine.disease ,Humanities - Abstract
espanolSegun la prevalencia y el impacto en la salud publica, la toxocariasis es una zoonosis subestimada en los paises en desarrollo y desarrollados. La transmision de Toxocara spp. involucra animales de compania caninos y felinos, como tambien perros y gatos sin hogar (Canis familiaris y Felis catus, respectivamente), que diseminan los huevos del parasito en sus heces al medio ambiente. Uno de los principales factores de riesgo para la infeccion y el desarrollo de la toxocariasis humana es convivir con cachorros felinos y caninos. Durante mucho tiempo, la estrategia preventiva para esta infeccion parasitaria ha sido el uso regular de medicamentos antiparasitarios para reducir la carga parasitaria a corto plazo. Se puede lograr una proteccion inmunologica duradera con la vacunacion, sin embargo, todavia no se dispone de una vacuna. Por lo tanto, es fundamental conocer y comprender el estado del arte del desarrollo de vacunas para el control efectivo de esta zoonosis. Este articulo revisa los estudios experimentales centrados en el desarrollo de vacunas para el control de la toxocariasis, y se presta especial atencion a los estudios epidemiologicos relevantes sobre la importancia de los caninos domesticos en la toxocariasis humana. EnglishBased on prevalence and impact on public health, toxocariasis is an underestimated zoonosis in developing and developed countries. The transmission of Toxocara spp. involves pets, stray dogs and cats (Canis familiaris and Felis catus, respectively), which spread the parasite’s eggs in their feces to the environment. One of the main risk factors for the infection and development of human toxocariasis, is to cohabit with puppies and kittens. For a long time, the preventive strategy for this parasitic infection has been the regular use of antiparasitic drugs to reduce parasite burden in the short term. A long lasting immunological protection can be achieved with vaccination, however, a vaccine is not yet available. Therefore, it is fundamental to know and to understand the state of the art of vaccine development for effective control of this zoonosis. This paper reviews the experimental studies focused on vaccine development for toxocariasis control, and special attention is given to relevant epidemiological studies on the importance of dogs in human toxocariasis. portuguesCom base na prevalencia e no impacto na saude publica, a toxocariase e uma zoonose subestimada nos paises em desenvolvimento e desenvolvidos. A transmissao de Toxocara spp. envolve animais caes e gatos de estimacao e vadios (Canis familiaris e Felis catus, respectivamente), que espalham os ovos do parasita nas fezes para o meio ambiente. Um dos principais fatores de risco para a infeccao e desenvolvimento da toxocariase humana e coabitar com filhotes de cachorros e gatos. Por um longo tempo, a estrategia preventiva para essa infeccao parasitaria tem sido o uso regular de medicamentos antiparasitarios para reduzir a carga parasitaria a curto prazo. Uma protecao imunologica duradoura pode ser alcancada com a vacinacao, no entanto, uma vacina ainda nao esta disponivel. Portanto, e fundamental conhecer e entender o estado da arte do desenvolvimento de vacinas para o controle efetivo dessa zoonose. Este artigo revisa os estudos experimentais focados no desenvolvimento de vacinas para o controle da toxocariase, e atencao especial e dada a estudos epidemiologicos relevantes sobre a importância dos caes na toxocariase humana.
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- 2020
44. A false-positive case on brain
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J R, Garcia, M, Baquero, P, Bassa, A, Compte, S, Mourelo, and E, Riera
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Multiple Sclerosis ,Positron-Emission Tomography ,Brain ,Humans ,Radiopharmaceuticals ,Choline - Published
- 2020
45. Beamforming Networks for antenna array, useful inWiFi applications
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Miguel Ferrando-Bataller, M. Baquero, Carlos Ramiro Peñafiel, Diana Verónica Navarro, and Luis Fernando Carrera
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Physics ,Butler Matrix ,lcsh:TA1-2040 ,WiFi ,lcsh:Technology (General) ,Rotman Lens ,lcsh:T1-995 ,lcsh:Engineering (General). Civil engineering (General) ,Humanities ,Array Antena ,Slots array with SIW guide ,Butler matrix - Abstract
En este articulo se han presentado varios tipos de redes conformadoras de haz, estas propuestas pueden ser utilizadas para una agrupacion de antenas utiles en diversos tipos aplicaciones. El primer diseno corresponde a una Matriz de Butler de 4X4 para una frecuencia de resonancia de 2.45 GHz, dependiendo del puerto por la cual la senal sea excitada, se podra obtener diversas variaciones en fase en los puertos de salida (45°, 135°, -45° y -135°), la matriz de Butler propuesta ha sido optimizada a partir de un esquema de matriz generalizada, reduciendo el tamano a traves de una simple superposicion de multiples lineas de transmision a l/4. El segundo diseno corresponde a una lente de Rotman con una frecuencia de resonancia caracteristica de 5.8 GHz, con un maximo angulo focal de 30°, para este diseno se ha utilizado el concepto de la optica geometrica, y el ultimo diseno ha sido realizado para una frecuencia de 5.8 GHz usando una agrupacion de ranuras disenadas con tecnologia Substrate Integrated Waveguide.
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- 2018
46. 6q21q22.2 Deletion Syndrome with Ataxia and Congenital Ocular Motor Apraxia (Cogan´s Syndrome)
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MC Carrascosa-Romero, M Baquero Cano, E Lozano-Setién, A Correas-Sánchez, AB Delgado García, and ER Méndez-Carrascosa
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Pediatrics ,medicine.medical_specialty ,S syndrome ,Ataxia ,business.industry ,Medicine ,Deletion syndrome ,medicine.symptom ,business ,Ocular Motor Apraxia - Abstract
Congenital oculomotor apraxia, also known as Cogan´s syndrome [Cogan-type congenital ocular motor apraxia (COMA, OMIM 257550)], is a rare hereditary disease that affects the eye insofar as it cannot make horizontal movements voluntary. Of unknown etiology, it was described by Cogan in 1952 and, classically considered as a sporadic disease with autosomal dominant inheritance in some cases, and as an indicator of partial metabolic alterations or defects of neurological development in others. We present a newborn with 6q21q22.1 microdeletion, result of gestation after in vitro fertilization, which clinically manifests movement disorders including ataxia and characteristic clinical picture of Cogan´s syndrome (oculomotor apraxia); highlighting microcephaly and peculiar phenotype characterized by small eyes, sparse hair, broad nasal root with epicanthus and hypoplasia of nasal wings. Cerebral ultrasound showed Cysts of the Subependymal. Germinal Matrix. The 6q deletions are infrequent, with around 100 cases described, associated with variable phenotypes, including dysmorphic features, growth retardation, upper limb malformations, and Prader-Willi (PW)-like features; and few of them studied with high resolution cytogenetic techniques. Recently, in the study of three patients (one with ataxia and two with movement disorders), the 6q22.1 region has been proposed as critical (including the MARCKS, HDAC2, and HS3ST5 genes), a region that is also affected in our patient, and correlated with the ataxia phenotype, as the most outstanding data. So, from these results, the genetic heterogeneity of Cogan syndrome is inferred. In this article we also review the bibliography related to oculomotor apraxia associated with other movement disorders such as ataxia.
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- 2018
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47. Estudio de fiabilidad en la interpretación del electrocardiograma por médicos de familia y médicos residentes
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F.J. Alonso Moreno, L. Rodríguez Padial, A.I. Rabadán Velasco, M. Baquero Alonso, R. Orueta Sánchez, A. Villarín Castro, L. Luna del Pozo, and A. Segura Fragoso
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03 medical and health sciences ,0302 clinical medicine ,Public Health, Environmental and Occupational Health ,030212 general & internal medicine ,030204 cardiovascular system & hematology ,Family Practice - Abstract
Resumen Objetivo Conocer la fiabilidad en la interpretacion del electrocardiograma (ECG) por medicos de familia en ejercicio y medicos residentes en periodo de formacion, utilizando para ello la comparacion con la interpretacion realizada por el cardiologo. Material y metodos Estudio observacional. Se incluyeron medicos de familia en ejercicio del Area de Salud de Toledo, medicos internos residentes de Medicina Familiar y Comunitaria y los medicos internos residentes de Cardiologia de los 3 anos iniciales del periodo formativo (R1-R3). Se utilizo un cuestionario con 13 ECG sin datos clinicos del paciente. Los 13 ECG fueron seleccionados y sus diagnosticos consensuados por 2 cardiologos del Complejo Hospitalario de Toledo. Resultados El porcentaje de respuestas correctas mas alto (82,3%) correspondio al ECG 5 (fibrilacion auricular), y el mas bajo (26,5%), al ECG 11 (ritmo de la union). La competencia diagnostica mas alta fue alcanzada por los medicos residentes de Cardiologia, los medicos de familia en ejercicio, los tutores de residentes y los medicos con trabajo en el Servicio de Urgencias del hospital. Los valores mas altos de odds ratio para una mayor competencia diagnostica fueron trabajar en el Servicio de Urgencias y ser medico de familia en ejercicio, ambas con resultados casi significativos (p Conclusiones Los medicos de familia y los medicos residentes tienen un grado de fiabilidad medio en la interpretacion del ECG con relacion al cardiologo.
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- 2018
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48. Complicaciones del infarto de miocardio
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L. Rodríguez Padial, F. Sabatel Pérez, and M. Baquero Alonso
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Medicine ,030212 general & internal medicine ,General Medicine ,030204 cardiovascular system & hematology ,business ,Humanities - Abstract
Resumen Introduccion El IAM es una de las principales causas de muerte en los paises desarrollados. Complicaciones La elevada mortalidad de esta patologia, a su vez, se debe a la frecuente aparicion de complicaciones. Las arritmias en general son las mas frecuentes en la fase aguda, siendo las ventriculares la principal causa de muerte en la fase prehospitalaria. Durante la hospitalizacion y despues de ella, sera sobre todo el grado de disfuncion ventricular y sus consecuencias las que condicionen el pronostico del paciente. Las complicaciones mecanicas, al igual que las anteriores mucho menos frecuentes en la era de la reperfusion precoz, tienen una alta letalidad pero son potencialmente corregibles, por lo que siempre hay que tenerlas en mente ante un paciente que se deteriora hemodinamicamente de forma brusca.
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- 2017
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49. Utilidad de la PET con 11C-metionina en la diferenciación precoz entre recurrencia tumoral y radionecrosis de pacientes tratados de glioma de alto grado con RM indeterminada
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M. Baquero, J. Rubio, G. Maida, A. Jaramillo, M. Soler, E. Riera, M. Cozar, J.M. Fernández Barrionuevo, and J.R. Garcia
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Nuclear medicine ,030218 nuclear medicine & medical imaging - Abstract
Resumen Objetivo Valorar la contribucion de la PET con 11C-metionina en la diferenciacion precoz entre recurrencia tumoral y radionecrosis en pacientes tratados de gliomas de alto grado. Metodo Treinta pacientes tratados de glioma (grado iii / iv ) con cirugia/radioterapia/quimioterapia (5-18 meses) con RM indeterminada. A todos se les realizo estudio de PET con 11C-metionina ( El manejo de los pacientes se decidio en el comite de neurooncologia: seguimiento clinico-imagen, tratamiento de segunda linea o cirugia. Resultados Veintitres estudios de PET con 11C-metionina fueron visualmente positivos. La morfologia fue: 15 focales, 4 difusos y 4 anulares. Tres de los focales fueron resecados (AP+). En 16 se realizo terapia de segunda linea (11 respuesta, 5 progresion). En los 4 de morfologia anular se decidio seguimiento, con progresion en 2 (verdaderos positivos) y libres de enfermedad en 2 (6 y 7 meses despues) (falsos positivos). Siete estudios de PET con 11C-metionina fueron visualmente negativos, todos ellos libres de enfermedad (3-12 meses). La relacion SUV lesion/fondo en la recurrencia tumoral fue de 2,79 ± 1,35 mientras que en la radionecrosis fue de 1,53 ± 0,39 (p Con umbral de corte SUV lesion/fondo de 2,35 se obtuvo una sensibilidad y especificidad del 90,5 y 100%. Conclusion La valoracion de la PET con 11C-metionina, con analisis visual, cuantitativo y corregistro PET/RM muestra un papel complementario en los pacientes con RM no concluyente, permitiendo una diferenciacion precoz entre recurrencia tumoral y radionecrosis, que ayuda a la individualizacion de la terapia.
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- 2017
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50. The value of 11 C-methionine PET in the early differentiation between tumor recurrence and radionecrosis in patients treated for a high-grade glioma and indeterminate MRI
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J. Rubio, M. Soler, G. Maida, M. Cozar, A. Jaramillo, E. Riera, M. Baquero, J.M. Fernández Barrionuevo, and J.R. Garcia
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Chemotherapy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Engineering ,medicine.disease ,030218 nuclear medicine & medical imaging ,Tumor recurrence ,Radiation therapy ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Glioma ,medicine ,General Earth and Planetary Sciences ,In patient ,Histopathology ,medicine.symptom ,Indeterminate ,business ,Nuclear medicine ,General Environmental Science - Abstract
Objective To evaluate the contribution of 11 C-Methionine PET in the early differentiation between tumor recurrence and radionecrosis in patients treated for a high grade glioma. Method The study included 30 patients with glioma (III/IV grade) treated with surgery/radiotherapy/chemotherapy (5–8 months) and with an indeterminate MRI. All patients underwent a 11 C-Methione PET (within 15 days of MRI) and studies were visually analyzed (intensity and morphology of uptake), quantified (SUV max/SUV mean background), and coregistered to MRI (3D-Flair). Patient management was decided by the neuro-oncology committee to clinical and imaging follow-up, second-line treatment, or surgery. Results There were 23 11 C-Methionine PET studies visually positive. Morphology of uptake was focal in 15, diffuse in 4, and ring-shaped in 4. Three out of the focal uptake cases underwent resection (Histopathology +). Sixteen underwent second-line therapy (11 responded; 5 progressed). The 4 cases with ring-shaped uptake were followed-up, and progression was found in 2 (true-positive), and disease-free in 2 (follow-up of 6 and 7 months, respectively) (false-positive). Seven out of 11 C-Methionine PET studies were visually negative, and all of them were disease-free (follow-up of 3–12 months). SUV lesion/background was 2.79 ± 1.35 in tumor recurrence, and 1.53 ± 0.39 in radionecrosis ( P Taking into account a SUV lesion/background threshold of 2.35, the sensitivity and specificity values were 90.5% and 100%, respectively. Conclusion Visual analysis, quantitative and PET/MRI coregistration of 11 C-Methionine PET showed their complementary role in patients with indeterminate MRI results, thus allowing early differentiation between tumor recurrence and radionecrosis, and helping in the individual therapy approach.
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- 2017
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