327 results on '"M, Dueñas"'
Search Results
2. Liquid Biopsy Characterization of CTCs and THCs Isolated in Patients with UC
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C. Rubio, I. Reina, J. Casalvilla-Dueñas, E. Montesinos, O. Alberquilla, D. Castellanos, F. Guerrero, J. Paramio, E. Lopez-Collazo, and M. Dueñas
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Medicine - Published
- 2023
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3. Novel and Non-invasive Tool for Immunotherapy-Response Prediction in Non-muscle-Invasive Bladder Cancer Patients Based on miRNAs and Cytokine Detection in Urine
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Á. Martín De Bernardo, E. Ramón-Gil, M. Rodríguez Izquierdo, F. Guerrero, D. Castellano, J. Paramio, M. Dueñas, and C. Suárez-Cabrera
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Medicine - Published
- 2023
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4. The psychoneuroendocrine response of aggression due to COVID-19 social isolation
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Angelica M. Palacio-Delgado, Miguel B. Cervera-Sánchez, Anna C. Selvas-Cortinas, Samuel A. Romo-Márquez, and Judith M. Dueñas-Jiménez
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COVID-19. Isolation. Aggression. Stress. ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The pandemic caused by the SARS-COV-2 virus in the years 2020-2022 altered the emotional behavior of humans. The restrictive feeling caused by the isolation and the change of life habits that demanded a social separation promoted anxiety, distress, apathy, domestic violence, educational problems, and economic instability, among other aspects. Erroneous statistics, and social media information about the number of people infected by the coronavirus SARS-COV-2, aggravated human anxiety and depression. This review compares the main psychological effects caused by pandemic isolation compared to other isolated social contexts. We studied the primary central nervous system areas involved in human reactive aggressiveness behavior. We examine this behavior in relationship with catecholamines and hormones during social isolation. We do not measure or analyze any hormone in our laboratory and only describe the circuits involved in the neuroendocrine response to the aggressive behavior.
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- 2023
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5. Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy
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I. Lodewijk, A. Bernardini, C. Suárez-Cabrera, E. Bernal, R. Sánchez, J. L. Garcia, K. Rojas, L. Morales, S. Wang, X. Han, M. Dueñas, J. M. Paramio, and L. Manso
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Platinum-based neoadjuvant chemotherapy followed by interval debulking surgery is an accepted treatment for patients with stage III or IV epithelial ovarian cancer who are not suitable for primary debulking surgery. The identification of suitable adjuvant treatments in these patients is an unmet need. Here, we explore potential genomic characteristics (mutational and immune-associated expression profiles) in a series of patients undergoing neoadjuvant chemotherapy. Tumor samples from biopsy and interval debulking surgery were analyzed for mutational landscape and immune profiling, together with detailed immunohistochemistry using different immune cell markers, and correlated with clinicopathological characteristics and potential response to neoadjuvant chemotherapy. No major differences in the mutational landscape were observed in paired biopsy and surgery samples. Genomic loss of heterozygosity was found to be higher in patients with total/near-total tumor response. The immune gene expression profile after neoadjuvant chemotherapy revealed activation of several immune regulation-related pathways in patients with no/minimal or partial response. In parallel, neoadjuvant therapy caused a significant increase of tumor-infiltrating lymphocyte population abundance, primarily due to an augmentation of the CD8+ T cell population. Remarkably, these changes occurred irrespective of potential homologous recombination defects, such as those associated with BRCA1/2 mutations. Our study strengthens the use of loss of heterozygosity as a biomarker of homologous repair deficiency. The changes of immune states during neoadjuvant chemotherapy reveal the dynamic nature of tumor-host immune interactions and suggest the potential use of immune checkpoint inhibitors or their combination with poly-ADP polymerase inhibitors in high stage and grade epithelial ovarian cancer patients undergoing neoadjuvant therapy.
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- 2022
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6. Spanish Adaptation of the Family Involvement Questionnaire - High School: Version for Parents
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Jorge M. Dueñas, Fabia Morales-Vives, Marta Camarero-Figuerola, and Juana M. Tierno-García
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family involvement ,assessment ,high school ,family ,Philosophy. Psychology. Religion ,Psychology ,BF1-990 - Abstract
Many studies highlight the importance of parental involvement in the academic performance of children and adolescents across subject areas. In view of the lack of instruments in Spain to assess family involvement of parents of adolescents, we undertook this study to develop the Spanish adaptation of the Family Involvement Questionnaire - High School version (FIQ-HS). The sample consisted of 928 parents (85.7 % females) with adolescent sons and daughters. Exploratory and confirmatory factor analyses substantiated the expected three-factor structure (home-school communication, school-based activities, and home-based activities), though seven poorly functioning items were removed. The results show that this instrument has adequate psychometric properties, good reliability, and convergence with another measure of family adaptability and cohesion. Therefore, the FIQ-HS is adequate for the assessment of family involvement in Spanish parents.
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- 2021
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- View/download PDF
7. Understanding the impact of the COVID-19-related lockdown in university workers. Identifying groups through cluster analysis
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H. De Sola, A. Salazar, J. Palomo-Osuna, M. Dueñas, I. Failde, and J.A. Moral-Munoz
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COVID-19 ,Lockdown ,Pandemic ,University workers ,Economic crisis ,Interpersonal factors ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Objective: To analyse the COVID-19-related lockdown impact on University workers, to identify groups based on this information, and to study the factors associated with each group. Study design: Cross-sectional study. Methods: A survey was conducted 3.5 weeks after COVID-19-related lockdown in University workers in Spain. Sociodemographic variables, housing, work, health conditions, levels of anxiety, stress and depression (DASS-21), and social support (MSPSS) were collected. A cluster analysis was performed to identify groups depending on the impact of the lockdown. Differences between groups were tested using Chi-square and Mann-Whitney-U tests, and associated factors with binary logistic regression. Results: We identified two groups of workers. “G1: Consequences in the daily life routine” was mainly composed of men, Research and Teaching Personnel (RTP) with more stable professional categories, higher income level, and bigger houses than people in G2. Participants in “G2: Concerns for the current and future well-being” presented worse intensity of pain than before the lockdown, more anxiety, depression, stress and less social support than people in G1. ASP (Administration and Services Personnel) had more risk of belonging to G2 than RTP (OR = 5.863). A higher number of people living at home decreased the risk of being in G2 (OR = 0.439). People with lower pain intensity had less risk of being in G2 (OR = 0.014), and this risk decreased as friends support increased (OR = 0.833). Conclusions: In G1, the consequences were immediately reflected in the stress resulting from changes in their daily work routine. In G2, the concerns were related to their professional future, with worse mental health, greater intensity of pain and less social support.
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- 2022
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8. Uso y duración de terapia antibiótica en la exacerbación pulmonar aguda de la fibrosis quística: un tema aún sin definir
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Ivan D. Lozada-Martinez, Fredy L Carreño-Hernández, Deiner Y. Muñoz-Delgado, Álvaro E. Marroquín-Murcia, Juan F. Sánchez-Erazo, Erick L. Rubio-Cano, Lina M. Acosta, John H. Cabrera-Ortiz, and Lina M. Dueñas-Triana
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fibrosis quística ,antibacterianos ,brote de los síntomas ,enfermedades pulmonares ,literatura de revisión como asunto ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
La fibrosis quística es una enfermedad sobre la que aún no se sabe mucho y sigue siendo un tema candente en la medicina traslacional y pulmonar. La evidencia sobre el manejo de las exacerbaciones es limitada, con pocos ensayos clínicos y revisiones sistemáticas. Por ejemplo, se desconoce el uso y la duración de los antibióticos en esta enfermedad. Teniendo en cuenta que se trata de una enfermedad que supone un elevado coste sanitario y que disminuye sustancialmente la capacidad funcional del afectado, es necesario establecer rápidamente algoritmos prácticos basados en la evidencia. En base a lo anterior, el objetivo de esta revisión narrativa es sintetizar evidencia sobre el uso y la duración del tratamiento antibiótico en las exacerbaciones pulmonares agudas en pacientes con fibrosis quística. Para esto, se llevó a cabo una búsqueda bibliográfica en los motores de búsqueda y bases de datos bases de datos PubMed, ScienceDirect, Embase, EBSCO y MEDLINE. Se definió que cualquier artículo relacionado con la evaluación del uso y duración de antibioticoterapia en la exacerbación aguda pulmonar del paciente con fibrosis quística, sería incluido, dando prioridad a los estudios originales y a las revisiones sistemáticas y meta-análisis. Posterior a la revisión del título y resumen de todos los resultados, se incluyeron 42 artículos. Se encontró que instaurar antibioticoterapia 10 días posterior al tratamiento estándar, por vía intravenosa, ya sea de doxiciclina o azitromicina más colistimetato, permite obtener mayor recuperación de la función pulmonar perdida, alargar el tiempo hasta la próxima exacerbación y solucionar sintomatología rápidamente.
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- 2022
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9. Direct laser synthesis and patterning of high entropy oxides from liquid precursors
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Alexander C Castonguay, Nabila Nabi Nova, Lauren M Dueñas, Shannon McGee, M J K Lodhi, Yang Yang, and Lauren D Zarzar
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laser synthesis ,laser patterning ,nanomaterials ,high entropy materials ,high entropy oxides ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Chemical technology ,TP1-1185 - Abstract
High entropy oxides are a class of materials distinguished by the use of configurational entropy to drive material synthesis. These materials are being examined for their exciting physiochemical properties and hold promise in numerous fields, such as chemical sensing, electronics, and catalysis. Patterning and integration of high entropy materials into devices and platforms can be difficult due to their thermal sensitivity and incompatibility with many conventional thermally-based processing techniques. In this work, we present a laser-based technique, laser-induced thermal voxels, that combines the synthesis and patterning of high entropy oxides into a single process step, thereby allowing patterning of high entropy materials directly onto substrates. As a proof-of-concept, we target the synthesis and patterning of a well-characterized rock salt-phase high entropy oxide, (Mg _0.2 Co _0.2 Ni _0.2 Cu _0.2 Zn _0.2 )O, as well as a spinel-phase high entropy oxide, (Mg _0.2 Ni _0.2 Co _0.2 Cu _0.2 Zn _0.2 )Cr _2 O _4 . We show through electron microscopy and x-ray analysis that the materials created are atomically homogenous and are primarily of the rock salt or spinel phase. These findings show the efficacy of laser induced thermal voxel processing for the synthesis and patterning of high entropy materials and enable new routes for integration of high entropy materials within microscale platform and devices.
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- 2023
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10. Parental Reports of Intervention Services and Prevalence of Teasing in a Multinational Craniofacial Microsomia Pediatric Study
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Johns, Alexis L., Luquetti, Daniela V., Heike, Carrie L., Drake, Amelia F., Roque, Milagros M. Dueñas, Hurtado-Villa, Paula, Pachajoa, Harry, Porras-Hurtado, Gloria Liliana, Zarante, Ignacio, and Magee, Leanne
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- 2021
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11. New models for donor-recipient matching in lung transplantations.
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J M Dueñas-Jurado, P A Gutiérrez, A Casado-Adam, F Santos-Luna, A Salvatierra-Velázquez, S Cárcel, C J C Robles-Arista, and C Hervás-Martínez
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Medicine ,Science - Abstract
ObjectiveOne of the main problems of lung transplantation is the shortage of organs as well as reduced survival rates. In the absence of an international standardized model for lung donor-recipient allocation, we set out to develop such a model based on the characteristics of past experiences with lung donors and recipients with the aim of improving the outcomes of the entire transplantation process.MethodsThis was a retrospective analysis of 404 lung transplants carried out at the Reina Sofía University Hospital (Córdoba, Spain) over 23 years. We analyzed various clinical variables obtained via our experience of clinical practice in the donation and transplantation process. These were used to create various classification models, including classical statistical methods and also incorporating newer machine-learning approaches.ResultsThe proposed model represents a powerful tool for donor-recipient matching, which in this current work, exceeded the capacity of classical statistical methods. The variables that predicted an increase in the probability of survival were: higher pre-transplant and post-transplant functional vital capacity (FVC), lower pre-transplant carbon dioxide (PCO2) pressure, lower donor mechanical ventilation, and shorter ischemia time. The variables that negatively influenced transplant survival were low forced expiratory volume in the first second (FEV1) pre-transplant, lower arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FiO2) ratio, bilobar transplant, elderly recipient and donor, donor-recipient graft disproportion requiring a surgical reduction (Tailor), type of combined transplant, need for cardiopulmonary bypass during the surgery, death of the donor due to head trauma, hospitalization status before surgery, and female and male recipient donor sex.ConclusionsThese results show the difficulty of the problem which required the introduction of other variables into the analysis. The combination of classical statistical methods and machine learning can support decision-making about the compatibility between donors and recipients. This helps to facilitate reliable prediction and to optimize the grafts for transplantation, thereby improving the transplanted patient survival rate.
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- 2021
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12. Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención. Un estudio de casos y controles
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Esteban A. Plasencia-Duenas, Cristian Diaz-Velez, and Milagros M. Dueñas-Roque
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Fisura del paladar ,Malformaciones congénitas ,Factores de riesgo ,Medicine - Abstract
Objetivo: identificar los factores asociados a la presencia de fisura labial y/o palatina en recién nacidos en el Hospital Nacional Edgardo Rebagliati Martins, localizado en Lima – Perú, durante el periodo noviembre 2012 - diciembre 2016. Materiales y métodos: estudio observacional, analítico, de casos y controles emparejado, con datos del Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAMC). Se analizaron 61 casos y 61 controles. La variable dependiente fue la presencia de fisura labial y/o palatina. Se recogieron también variables clínicas, epidemiológicas, obstétricas y prenatales. Resultados: la fisura labiopalatina con extensión completa, en el sexo masculino, fue la forma más frecuente y estuvo presente en 36 neonatos (59%), con cariotipo normal 44 (75,9%) y sin diagnóstico prenatal 40 (65,6%). Las malformaciones observadas con más frecuencia fueron las faciales 27 (44,2%) seguidas de malformaciones cardiacas (29,6%). Se construyó un modelo estadístico mediante análisis multivariado conformado por tres variables: enfermedad crónica durante el embarazo (odds ratio [OR]: 3,8; intervalo de confianza al 95% [IC 95%]: 1,11 - 13,08), edad materna mayor a 35 años (OR: 6,85; IC 95%: 2,69 - 17,43) y antecedente familiar (OR: 14,5; IC 95%: 1,68 - 125,56). Conclusiones: las enfermedades crónicas en el embarazo, la edad materna avanzada y el antecedente familiar fueron factores que aumentaron la presencia de fisura labial y/o palatina.
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- 2020
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13. Novel mutation in ENG gene causing Hereditary Hemorrhagic Telangiectasia in a Peruvian family
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Alejandro Zevallos-Morales, Alexis Murillo, Milagros M. Dueñas-Roque, Ana Prötzel, Luis Venegas-Tresierra, Verónica Ángeles-Villalba, Miguel Guevara-Cruz, Ada Chávez-Gil, Ricardo Fujita, and Maria L. Guevara-Fujita
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ENG ,Hereditary Hemorrhagic Telangiectasia ,Osler-Weber-Rendu disease ,Genetics ,QH426-470 - Abstract
Abstract Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder of vascular development. Common manifestations include epistaxis, telangiectasias and arteriovenous malformations (AVMs) in multiple organs. Most patients have deletions or missense mutations in the ENG or ACVRL1 gene respectively, significantly affecting endothelium homeostasis. We analyzed the ENG gene in five members of a Peruvian family affected by HHT. One novel mutation was found in exon four of the ENG gene c.408delA, at aminoacid residue 136. This mutation changes the subsequent reading frame producing an early stop at residue 162, preserving only one fourth of the normal protein of 658 aa. This mutation was found in the four affected members of family.
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- 2020
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14. Infecciones por el virus de la influenza
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G. Barahona, M. Dueñas, and E. Pleites
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General Medicine - Published
- 2022
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15. Are older teens more frustrated than younger teens by the covid-19 restrictions? The role of psychological maturity, personality traits, depression and life satisfaction
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Fabia Morales-Vives, Pere J. Ferrando, Jorge-M. Dueñas, Sergi Martín-Arbós, M. Dolores Varea, and Elena Castarlenas
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General Psychology - Abstract
Many studies have shown the negative impact of lockdowns on adolescents, but there is less evidence on how they are affected by other stages of the COVID-19 pandemic, and, especially, whether there are any differences between early and late adolescence. The current study focuses on the frustration felt by adolescents because of the severe COVID-19 restrictions in a non-lockdown situation. We aimed to (a) assess the role of maturity and two personality traits (emotional stability and extraversion) in predicting their frustration, and (b) compare the levels of frustration, depressive symptoms, and life satisfaction in older and younger adolescents. The sample of older adolescents was also compared with a paired sample of the same age collected in 2018, before the pandemic. The results suggest that maturity, extraversion and emotional stability are predictors of frustration in both older and younger adolescents, although older adolescents reported higher levels of frustration and depressive symptoms, and lower levels of life satisfaction. Older adolescents also reported higher levels of depressive symptoms than adolescents of the same age before the pandemic. These results show the negative impact of the pandemic, especially on older adolescents, and the important role of maturity and some personality traits in predicting their frustration.
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- 2023
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16. In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
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D. Rico, A.B. Martín-Diana, C. Martínez-Villaluenga, L. Aguirre, J.M. Silván, M. Dueñas, D.A. De Luis, and A. Lasa
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Food science ,Food analysis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g−1, respectively). Pod mostly contained gallic acid and gallotannins; seed peel and germ's showed as most abundant polyphenols quercetin and apigenin derivatives. Carob pod and seed peel revealed stronger antioxidant capacities compared to germ. The strongest antihypertensive activity was found in seed peel, followed by pod and germ. Anti-inflammatory activity showed inhibition of NO production in LPS-induced macrophages, although only pod was able of reducing pro-inflammatory mediators (TNF-α andPGD2). Finally, fat accumulation on mature adipocytes was reduced by carob seed peel and pod extracts. This work shows the potential use of pod carob by-products as food ingredients with special relevance of carob pod for attenuating metabolic syndrome.
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- 2019
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17. Spanish Adaptation of the Family Involvement Questionnaire - High School: Version for Parents
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Marta Camarero-Figuerola, Juana M. Tierno-García, Jorge M. Dueñas, and Fabia Morales-Vives
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high school ,family ,Social Psychology ,Family involvement ,assessment ,Philosophy. Psychology. Religion ,05 social sciences ,family involvement ,050301 education ,BF1-990 ,Cohesion (linguistics) ,Developmental and Educational Psychology ,Subject areas ,Psychology ,0501 psychology and cognitive sciences ,Convergence (relationship) ,Adaptation (computer science) ,0503 education ,050104 developmental & child psychology ,Clinical psychology - Abstract
Many studies highlight the importance of parental involvement in the academic performance of children and adolescents across subject areas. In view of the lack of instruments in Spain to assess family involvement of parents of adolescents, we undertook this study to develop the Spanish adaptation of the Family Involvement Questionnaire - High School version (FIQ-HS). The sample consisted of 928 parents (85.7 p females) with adolescent sons and daughters. Exploratory and confirmatory factor analyses substantiated the expected three-factor structure (home-school communication, school-based activities, and home-based activities), though seven poorly functioning items were removed. The results show that this instrument has adequate psychometric properties, good reliability, and convergence with another measure of family adaptability and cohesion. Therefore, the FIQ-HS is adequate for the assessment of family involvement in Spanish parents.
- Published
- 2021
18. ¿Cuál es el rol actual de la toracocentesis en el hidrotórax fetal severo? Presentación de caso
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Oswaldo Tipiani Rodríguez, Miguel A. Ponciano Biaggi, Gian C Pérez Fleming, Israel M Gonzales Enríquez, Liz K Andrés Calvo, Julissa Y Pita Álvarez, Milagros M Dueñas Roque, and Percy Pantoja Soto
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General Medicine - Abstract
Se llama hidrotórax a una efusión pleural primaria que ocurre durante la vida prenatal (denominado ‘quilotórax primario’ después del nacimiento). En ciertos casos, esta efusión es severa y produce compresión pulmonar y cardiaca, por lo cual, la mortalidad perinatal sigue siendo alta. Los recién nacidos con hidrotórax requieren, muchas veces, de drenaje, nutrición parenteral total y medicación específica para su recuperación. Sin embargo, las intervenciones prenatales, principalmente con derivaciones toraco-amnióticas, pueden mejorar estos resultados. Reportamos el caso de un feto con hidrotórax severo a quien se le realizó una toracocentesis y revisamos la literatura acerca de su rol en el tratamiento prenatal actual.
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- 2022
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19. Spanish Adaptation of the Family Involvement Questionnaire-High School: Version for Parents
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Universitat Rovira i Virgili, Jorge M Dueñas; Fabia Morales-Vives; Marta Camarero-Figuerola; Juana M Tierno-García, Universitat Rovira i Virgili, and Jorge M Dueñas; Fabia Morales-Vives; Marta Camarero-Figuerola; Juana M Tierno-García
- Abstract
Muchos estudios subrayan la importancia de la implicación familiar en el rendimiento académico de niños y adolescentes en diferentes materias. Teniendo en cuenta la falta de instrumentos en España para evaluar la implicación familiar de los padres de adolescentes, se ha llevado a cabo este estudio para desarrollar una adaptación española del instrumento Family Involvement Questionnaire - High School version (FIQ-HS). La muestra constó de 928 padres (85.7% mujeres) con hijos e hijas adolescentes. Los análisis factoriales exploratorio y confirmatorio confirmaron la estructura esperada de tres factores (comunicación hogar-escuela, actividades basadas en la escuela y actividades basadas en el hogar), aunque se eliminaron siete ítems que presentaban mal funcionamiento. Los resultados muestran que este instrumento presenta unas adecuadas propiedades psicométricas, buena fiabilidad y convergencia con otra medida de adaptabilidad familiar y cohesión. Por lo tanto, el FIQ-HS es adecuado para evaluar la implicación familiar de los padres españoles.
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- 2022
20. Exploring the Communication of Social Movements in Primary Education
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Història i Història de l'Art, Psicologia, Universitat Rovira i Virgili, García-Gómez M; Dueñas JM; Irigoyen A, Història i Història de l'Art, Psicologia, Universitat Rovira i Virgili, and García-Gómez M; Dueñas JM; Irigoyen A
- Abstract
There is much controversy today about several factors involved in children’s education. The last decade has also seen a significant change in the way classes are imparted, with teachers giving greater visibility to subjects of current importance. One of these subjects is the issue of social movements. The present study aimed to identify possible communication strategies between primary school teachers and children and identify possible pedagogical strategies to explain, treat and discuss social movements in classrooms. To carry out the objectives, we used a Delphi method, and we drew on the experience of experts in several social and educational fields to identify the communication strategies. This interactive technique, comprising different phases and a range of questions, was used with experts in the psychology of education, media studies, primary education, and parents to reach a consensus on how best to approach social conflicts in the classroom and obtain predictions. The implications for primary education are discussed.
- Published
- 2022
21. Assessing the Construct Validity and Internal Reliability of the Screening Tool Test Your Memory in Patients with Chronic Pain.
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B Ojeda, A Salazar, M Dueñas, L M Torres, J A Mico, and I Failde
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Medicine ,Science - Abstract
Patients with chronic pain often complain about cognitive difficulties, and since these symptoms represent an additional source of suffering and distress, evaluating the cognitive status of these patients with valid and reliable tests should be an important part of their overall assessment. Although cognitive impairment is a critical characteristic of pain, there is no specific measure designed to detect these effects in this population. The objective was to analyze the psychometric properties of the "Test Your Memory" (TYM) test in patients with chronic pain of three different origins. A cross-sectional study was carried out on 72 subjects free of pain and 254 patients suffering from different types of chronic pain: neuropathic pain (104), musculoskeletal pain (99) and fibromyalgia (51). The construct validity of the TYM was assessed using the Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADs), Index-9 from MOS-sleep, SF-12, and through the intensity (Visual Analogical Scale) and duration of pain. An exploratory factor analysis was also performed and internal reliability was assessed using Cronbach's alpha. After adjusting for potential confounders the TYM could distinguish between pain and pain-free patients, and it was correlated with the: MMSE (0.89, p
- Published
- 2016
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22. Parental Reports of Intervention Services and Prevalence of Teasing in a Multinational Craniofacial Microsomia Pediatric Study
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Carrie L. Heike, Milagros M. Dueñas Roque, Alexis L. Johns, Paula Hurtado-Villa, Harry Pachajoa, Gloria Liliana Porras-Hurtado, Daniela V Luquetti, Leanne Magee, Amelia F. Drake, and Ignacio Zarante
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Hearing aid ,Male ,Parents ,medicine.medical_specialty ,Adolescent ,Hearing loss ,medicine.medical_treatment ,Population ,Psychological intervention ,Special education ,Article ,Goldenhar Syndrome ,Intervention (counseling) ,Prevalence ,Medicine ,Humans ,education ,Child ,Congenital Microtia ,education.field_of_study ,business.industry ,Microtia ,General Medicine ,medicine.disease ,Otorhinolaryngology ,Caregivers ,Family medicine ,Child, Preschool ,Surgery ,medicine.symptom ,business ,Psychosocial - Abstract
Children with craniofacial microsomia (CFM) are at increased risk for educational and social concerns. This study describes intervention services and frequency of teasing in a multinational population of children with CFM. Caregivers of children with CFM ages 3 to 18 years in the US and South America were administered a questionnaire. Additional information was gathered from medical charts and photographs. Participants (N = 169) had an average age of 10.1 ± 6.2 years, were primarily male (60%), and from the US (46%) or Colombia (32%). Most participants had microtia and mandibular hypoplasia (70%). They often had unilateral (71%) or bilateral (19%) hearing loss and 53% used a hearing aid. In the US, special education services were provided for 48% of participants enrolled in school; however, similar services were rare (4%) in South America and reflect differences in education systems. Access to any intervention service was higher in the US (80%) than in South America (48%). Caregivers reported children showed diagnosis awareness by an average age of 4.4 ± 1.9 years. Current or past teasing was reported in 41% of the children, starting at a mean age of 6.0 ± 2.4 years, and most often took place at school (86%). As half of the US participants received developmental and academic interventions, providers should screen for needs and facilitate access to services. Given diagnosis awareness at age 4 and teasing at age 6, providers are encouraged to assess for psychosocial concerns and link to resources early in treatment.
- Published
- 2021
23. La redacción como proceso: recursos electrónicos comentados para el inglés académico
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Pascual Pérez Paredes, P. Aguado, P. Sánchez, F. Mena, L. Cerezo, and M. Dueñas
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Language. Linguistic theory. Comparative grammar ,P101-410 - Published
- 2015
24. Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
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Fabiola Vaca-Cornejo, Héctor Macías Reyes, Sergio H. Dueñas Jiménez, Ricardo A. Llamas Velázquez, and Judith M. Dueñas Jiménez
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chitosan ,hydroxyapatite ,periodontitis ,guided bone regeneration ,Biotechnology ,TP248.13-248.65 ,Medicine (General) ,R5-920 - Abstract
Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis. Patients were evaluated through X-ray images and a millimetric slide over a one year period. The application of CH/HAP produced an average alveolar bone growth of 5.77 mm (±1.87 mm). At the onset of the study, the dental pocket exhibited a depth level (DPDL) of 8.66 mm and decreased to 3.55 mm one year after the implant. Tooth mobility grade was 2.44 mm at the onset and 0.8 mm at the end of the study with a significant difference of p < 0.001. Moreover, the bone density in the affected areas was similar to the density of the bone adjacent to it. This result was confirmed with the software implant viewer from Anne Solutions Company. In conclusion, the CH/HAP implant promoted alveolar bone growth in periodontitis patients.
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- 2017
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25. New models for donor-recipient matching in lung transplantations
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Pedro Antonio Gutiérrez, S. Cárcel, C. J. C. Robles-Arista, A. Salvatierra-Velázquez, J. M. Dueñas-Jurado, A. Casado-Adam, F. Santos-Luna, César Hervás-Martínez, [Dueñas-Jurado,JM, Cárcel,S, Robles-Arista,CJC] Intensive Care Unit, Reina Sofia University Hospital, Cordoba, Spain. [Gutiérrez,PA, Hervás-Martínez,C] Department of Computer Science and Numerical Analysis, Universidad de Córdoba, Córdoba, Spain. [Casado-Adam,A] General and Digestive Surgery Unit, Reina Sofia University Hospital, Cordoba, Spain. [Santos-Luna,F] Pneumology and Lung Transplant Service, Reina Sofia University Hospital, Cordoba, Spain. [Salvatierra-Velázquez,A] Thoracic Surgery and Lung Transplantation Service, Reina Sofia University Hospital, Cordoba, Spain. [Cárcel,S] Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Cordoba, Spain., and This study was funded by the Spanish Ministry of Economy and Competitiveness (MINECO), and FEDER funds (EU) to PAG and CHM (TIN2017-85887-C2-1-P and TIN2017- 90567-REDT).
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Male ,Vital capacity ,Critical Care and Emergency Medicine ,Traumatic Brain Injury ,medicine.medical_treatment ,Respiratory System ,030204 cardiovascular system & hematology ,Concepción de donantes ,Vascular Medicine ,law.invention ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,law ,Persons::Persons::Tissue Donors [Medical Subject Headings] ,Ischemia ,Fraction of inspired oxygen ,Medicine and Health Sciences ,Respiratory System Procedures ,Trauma Medicine ,Multidisciplinary ,Graft Survival ,Tissue Donors ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Lung Transplantation [Medical Subject Headings] ,Survival Rate ,Chemistry ,Obtención de tejidos y órganos ,Donation ,Physical Sciences ,Lung transplantations ,Medicine ,Female ,Anatomy ,Donor ,Traumatic Injury ,Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Survival [Medical Subject Headings] ,Research Article ,Lung Transplantation ,Chemical Elements ,medicine.medical_specialty ,Tissue and Organ Procurement ,Science ,Check Tags::Male [Medical Subject Headings] ,Surgical and Invasive Medical Procedures ,Health Care::Health Care Facilities, Manpower, and Services::Health Services::Tissue and Organ Procurement [Medical Subject Headings] ,03 medical and health sciences ,FEV1/FVC ratio ,Trasplante de pulmón ,medicine ,Cardiopulmonary bypass ,Lung transplantation ,Humans ,Intensive care medicine ,Mechanical ventilation ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Transplantation ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings] ,business.industry ,Biology and Life Sciences ,Organ Transplantation ,Receptores de trasplantes ,Transplant Recipients ,Oxygen ,030228 respiratory system ,Check Tags::Female [Medical Subject Headings] ,Spain ,Trasplante ,Lungs ,business ,Neurotrauma - Abstract
ObjectiveOne of the main problems of lung transplantation is the shortage of organs as well as reduced survival rates. In the absence of an international standardized model for lung donor-recipient allocation, we set out to develop such a model based on the characteristics of past experiences with lung donors and recipients with the aim of improving the outcomes of the entire transplantation process.MethodsThis was a retrospective analysis of 404 lung transplants carried out at the Reina Sofía University Hospital (Córdoba, Spain) over 23 years. We analyzed various clinical variables obtained via our experience of clinical practice in the donation and transplantation process. These were used to create various classification models, including classical statistical methods and also incorporating newer machine-learning approaches.ResultsThe proposed model represents a powerful tool for donor-recipient matching, which in this current work, exceeded the capacity of classical statistical methods. The variables that predicted an increase in the probability of survival were: higher pre-transplant and post-transplant functional vital capacity (FVC), lower pre-transplant carbon dioxide (PCO2) pressure, lower donor mechanical ventilation, and shorter ischemia time. The variables that negatively influenced transplant survival were low forced expiratory volume in the first second (FEV1) pre-transplant, lower arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FiO2) ratio, bilobar transplant, elderly recipient and donor, donor-recipient graft disproportion requiring a surgical reduction (Tailor), type of combined transplant, need for cardiopulmonary bypass during the surgery, death of the donor due to head trauma, hospitalization status before surgery, and female and male recipient donor sex.ConclusionsThese results show the difficulty of the problem which required the introduction of other variables into the analysis. The combination of classical statistical methods and machine learning can support decision-making about the compatibility between donors and recipients. This helps to facilitate reliable prediction and to optimize the grafts for transplantation, thereby improving the transplanted patient survival rate.
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- 2021
26. Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy
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I. Lodewijk, A. Bernardini, C. Suárez-Cabrera, E. Bernal, R. Sánchez, J. L. Garcia, K. Rojas, L. Morales, S. Wang, X. Han, M. Dueñas, J. M. Paramio, L. Manso, Institut Català de la Salut, [Lodewijk I] Biomedical Research Institute I+12, University Hospital '12 de Octubre', Madrid, Spain. Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain. Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Bernardini A] Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Suárez-Cabrera C] Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain. Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Bernal E] Medical Oncology, University Hospital 12 De Octubre, Madrid, Spain. Medical Oncology, Infant Cristina University Hospital, Madrid, Spain. [Sánchez R] Medical Oncology, University Hospital 12 De Octubre, Madrid, Spain. [Garcia JL] Pathology Department, University Hospital 12 De Octubre, Madrid, Spain. [Rojas K] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Cancer Research ,Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms [DISEASES] ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Genetic Phenomena::Gene Expression [PHENOMENA AND PROCESSES] ,Ovaris - Càncer - Tractament ,neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas [ENFERMEDADES] ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,Expressió gènica ,Quimioteràpia combinada ,Article ,Therapeutics::Combined Modality Therapy::Neoadjuvant Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Oncology ,Ovarian cancer ,terapéutica::tratamiento combinado::tratamiento neoadyuvante [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,fenómenos genéticos::expresión génica [FENÓMENOS Y PROCESOS] ,RC254-282 - Abstract
Ovarian cancer Càncer d'ovari Cáncer de ovario Platinum-based neoadjuvant chemotherapy followed by interval debulking surgery is an accepted treatment for patients with stage III or IV epithelial ovarian cancer who are not suitable for primary debulking surgery. The identification of suitable adjuvant treatments in these patients is an unmet need. Here, we explore potential genomic characteristics (mutational and immune-associated expression profiles) in a series of patients undergoing neoadjuvant chemotherapy. Tumor samples from biopsy and interval debulking surgery were analyzed for mutational landscape and immune profiling, together with detailed immunohistochemistry using different immune cell markers, and correlated with clinicopathological characteristics and potential response to neoadjuvant chemotherapy. No major differences in the mutational landscape were observed in paired biopsy and surgery samples. Genomic loss of heterozygosity was found to be higher in patients with total/near-total tumor response. The immune gene expression profile after neoadjuvant chemotherapy revealed activation of several immune regulation-related pathways in patients with no/minimal or partial response. In parallel, neoadjuvant therapy caused a significant increase of tumor-infiltrating lymphocyte population abundance, primarily due to an augmentation of the CD8+ T cell population. Remarkably, these changes occurred irrespective of potential homologous recombination defects, such as those associated with BRCA1/2 mutations. Our study strengthens the use of loss of heterozygosity as a biomarker of homologous repair deficiency. The changes of immune states during neoadjuvant chemotherapy reveal the dynamic nature of tumor-host immune interactions and suggest the potential use of immune checkpoint inhibitors or their combination with poly-ADP polymerase inhibitors in high stage and grade epithelial ovarian cancer patients undergoing neoadjuvant therapy. This study was funded by GlaxoSmithKline (GSK). I.L. position is funded by Fundación Científica Asociación Española Contra el Cáncer (AECC), Predoctoral AECC 2019 grant number PRDMA19024LODE. L. Morales position is funded by AECC, Postdoctoral AECC 2019 grant number POSTD19036MORA. This study was partially co-funded by European Regional Development Fund (FEDER) grants from Science and Innovation (SAF2015-66015-R and PID2019-110758RB-I00 to J.M.P.) and Instituto de Salud Carlos III (CIBERONC no. CB16/12/00228 to J.M.P.).
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- 2021
27. Challenging Cases in Clinical Research Ethics
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Benjamin S Wilfond, Liza-Marie Johnson, Devan M Duenas, Holly A Taylor, Benjamin S Wilfond, Liza-Marie Johnson, Devan M Duenas, and Holly A Taylor
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- Risk
- Abstract
Clinical research ethics consultation has emerged in the last 15 years as a service to those involved in the conduct of clinical research who face challenging issues for which more than one course of action may be justified. To respond to a growing field and need for opportunities to share knowledge and experience, the Clinical Research Ethics Consultation Collaborative, established in 2014, holds monthly webinars for its 90 members to present their most challenging cases to each other and engage in substantive discussion. Every year, the group selects the four most interesting cases with accompanying commentaries for publication in the American Journal of Bioethics. This timely book brings together these cases and commentaries under a range of common themes for the first time, creating a permanent collection in book format that encourages and supports readers to gain a better understanding of the ethical challenges that they may face, and providing them with a convenient and reflective resource to reference in their own deliberations.Key Features:• Comprehensive collection of cases and commentaries, chosen to reflect the range of issues faced by clinical researchers and oversight committees and illustrate the diversity of analysis that can arise • Supplemented by short introductions to each section • Focus on ethical rather than regulatory issues • Essential reading for graduate students in bioethics and post-doctoral bioethics fellows, and useful for all participants in training grants that are funded by either NIH or NSFPresenting challenging cases to stimulate reflection, the book provides invaluable guidance to clinicians in training and in practice and to investigators, bioethics consultants, regulators, and oversight bodies.
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- 2023
28. Checklist of the cestode parasites of wild birds of Argentina
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V Núñez, M Dueñas Díaz, R Draghi, and Fabiana B. Drago
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Bird Diseases ,Host (biology) ,Cestoda ,Argentina ,Zoology ,General Medicine ,Biology ,Cestode Infections ,Anatidae ,biology.organism_classification ,Family hymenolepididae ,Checklist ,Birds ,Taxon ,Animals ,Parasite hosting ,Helminths ,Animal Science and Zoology ,Parasitology - Abstract
An annotated checklist of the cestode parasites of Argentinean wild birds is presented, as the result of a compilation of parasitological papers published between 1900 and April 2021. This review provides data on hosts, geographical distribution, sites of infection, location of material deposited in helminthological collections, references and taxonomic comments. A host/parasite list is also provided. During this period, 38 papers were published that gather information about 34 cestode nominal species and 11 taxa identified at generic level, belonging to three orders, ten families and 35 genera. The highest number of cestode taxa was recorded in the family Hymenolepididae, with 12 nominal species and two taxa identified at generic level, followed by Dilepididae, with eight nominal species and three taxa identified at generic level. Of the 1042 species of birds reported in Argentina, only 29 (2.8%) were reported as hosts of adult cestodes. The families of birds with the highest number of reported taxa were Laridae and Anatidae, with 20 and 14 taxa, respectively.
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- 2021
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29. Allocation Optimization Problem for Peruvian Food Bank
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Renzo A. Benavente-Sotelo, Christian A. Blas-Bazán, Stephanie M. Dueñas-Calderón, Pamela Ivonne Borja-Ramos, Jorge Luis Yupanqui-Chacón, Ricardo Campos-Caycho, Pamela Arista-Yampi, Yasser A. Hidalgo-Gómez, and Patricia Elkfury-Cominges
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Optimization problem ,020303 mechanical engineering & transports ,021103 operations research ,Operations research ,0203 mechanical engineering ,Economics ,0211 other engineering and technologies ,02 engineering and technology ,Food bank - Abstract
Food insecurity is a recurrent condition in which members of a household do not have enough food to cover their nutritional needs; this condition contributes to increasing social vulnerability of those affected. In Peru, there are more than 9 million people who suffer this condition, which generates malnutrition and anemia, mostly in children. On the other hand, the waste of food is associated with production the large amounts of greenhouse gas emissions that affect global warming. According to reports in Peru, 20% of what is food produced becomes waste. This scenario in terms of food for Peruvians represents 3 billion calories in wasted food that could feed 2 million people. The Peruvian Food Bank manages food donations, ensuring this food can reach people in need through humanitarian aid entities. This applied research work uses the tools of operations research to determine a solution to the problem of maximizing the combination of food orders to be distributed based on their total nutritional value to the beneficiaries, seeking maximum coverage and minimum logistic costs.
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- 2021
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30. MLPA followed by target-NGS to detect mutations in the dystrophin gene of Peruvian patients suspected of DMD/DMB
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Milagros M. Dueñas-Roque, Carlos A. Castaneda, Victoria Marca, Ricardo Fujita, Hugo Abarca, Daisy Obispo, Luis Celis, Mario Cornejo-Olivas, Alejandro Estrada-Cuzcano, Milana Trubnykova, Victor Barrenechea, Francia Huaman-Dianderas, Bertha Gallardo, Ana Protzel, Diana Rojas-Málaga, Maria Luisa Guevara-Fujita, Jorge La Serna-Infantes, and Rodrigo Sánchez
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Male ,Duchenne muscular dystrophy ,Population ,QH426-470 ,Dystrophin ,Exon ,Gene Frequency ,Gene duplication ,Peru ,molecular diagnosis ,medicine ,Genetics ,Humans ,Multiplex ,Multiplex ligation-dependent probe amplification ,Genetic Testing ,Indel ,education ,Child ,Molecular Biology ,Genetics (clinical) ,targeted Next Generation Sequencing ,education.field_of_study ,business.industry ,Point mutation ,Original Articles ,medicine.disease ,Muscular Dystrophy, Duchenne ,Becker muscular dystrophy ,multiple ligation probe amplification ,Original Article ,business - Abstract
Background We report the molecular analysis of the DMD gene in a group of Peruvian patients with Duchenne/Becker dystrophinopathy. This is the first study to thoroughly characterize mutations in this population. Methods We used the combination of multiplex ligation‐dependent probe amplification (MLPA) and sequencing analysis of the DMD gene. We recruited Peruvian patients in 2 years from reference national hospitals. We performed DNA tests in 152 patients, checking first exon deletion/duplication by MLPA, and subsequently, if negative, samples were sequenced to detect point mutations. Results The average age for diagnosis was 9.8 years, suggesting a delay for timely diagnosis and care. We found causal DMD mutations in 125 patients: 72 (57.6%) exon deletions/duplications (41.6% deletions, 16.0% duplications), and 53 (42.4%) point mutations (27.2% nonsense, 9.6% small indels, and 5.6% splice site). Conclusion Due to our genetic background, we expected a higher number of novel and recurrent causal mutations in our sample. Results showed 16% of novel mutations, similar to other well‐studied populations., This study characterizes DMD/DMB mutations in Peru. This population has been poorly studied at the genetic level. We want to obtain a landscape of mutations affecting patients and give them treatment options with therapies currently under use in other countries. We found that deletions of the DMD gene, are predominant (41.6%) and point mutations with more than 40% of cases, explain the other cases. Duplications (16%) come in third place in this study. Regarding point mutations, the nonsense type (27%) is the most frequent change found.
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- 2021
31. Haploinsufficiency of SF3B2 causes craniofacial microsomia
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Milagros M. Dueñas-Roque, Casey Griffin, Leanne Magee, Cheryl A Wise, Andrew T. Timberlake, Jennie Slee, Harry Pachajoa, Rhonda E. Schnur, Carrie L. Heike, Jean Pierre Saint-Jeannet, David A. Staffenberg, Natalya Karp, Gloria Liliana Porras-Hurtado, Ignacio Zarante, Steven L. Singer, Jonas A Gustafson, Daniela V Luquetti, Mark R. Davis, Paula Hurtado-Villa, Sureni V Mullegama, Soghra J Doust, David Chitayat, Alexis L. Johns, Anne V. Hing, Amelia F. Drake, Nigel G. Laing, Andrew E. Timms, Michael L. Cunningham, and Jack Goldblatt
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Proband ,Adult ,Male ,Adolescent ,Science ,General Physics and Astronomy ,Haploinsufficiency ,Bioinformatics ,Genome informatics ,General Biochemistry, Genetics and Molecular Biology ,Article ,Xenopus laevis ,Cranial neural crest ,Goldenhar Syndrome ,medicine ,Animals ,Humans ,Exome ,DNA sequencing ,Craniofacial ,Child ,Genetic Association Studies ,Small nuclear ribonucleoprotein complex ,Multidisciplinary ,business.industry ,Microtia ,Infant ,General Chemistry ,medicine.disease ,Hypoplasia ,Pedigree ,Neural Crest ,Mutation ,Spliceosomes ,Female ,RNA Splicing Factors ,business ,Medical genomics - Abstract
Craniofacial microsomia (CFM) is the second most common congenital facial anomaly, yet its genetic etiology remains unknown. We perform whole-exome or genome sequencing of 146 kindreds with sporadic (n = 138) or familial (n = 8) CFM, identifying a highly significant burden of loss of function variants in SF3B2 (P = 3.8 × 10−10), a component of the U2 small nuclear ribonucleoprotein complex, in probands. We describe twenty individuals from seven kindreds harboring de novo or transmitted haploinsufficient variants in SF3B2. Probands display mandibular hypoplasia, microtia, facial and preauricular tags, epibulbar dermoids, lateral oral clefts in addition to skeletal and cardiac abnormalities. Targeted morpholino knockdown of SF3B2 in Xenopus results in disruption of cranial neural crest precursor formation and subsequent craniofacial cartilage defects, supporting a link between spliceosome mutations and impaired neural crest development in congenital craniofacial disease. The results establish haploinsufficient variants in SF3B2 as the most prevalent genetic cause of CFM, explaining ~3% of sporadic and ~25% of familial cases., Despite being a common congenital facial anomaly, the genetic etiology of craniofacial microsomia (CFM) is not well understood. Here, the authors use exome and genome sequencing of 146 individuals with CFM to identify haploinsufficient variants in SF3B2 as a prevalent underlying cause.
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- 2020
32. Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención. Un estudio de casos y controles
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Milagros M. Dueñas-Roque, Esteban Alberto Plasencia-Dueñas, and Cristian Díaz-Vélez
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Gynecology ,medicine.medical_specialty ,Pregnancy ,Multivariate analysis ,General Computer Science ,business.industry ,lcsh:R ,lcsh:Medicine ,Prenatal diagnosis ,Odds ratio ,malformaciones congénitas ,medicine.disease ,Confidence interval ,fisura del paladar ,Epidemiology ,medicine ,factores de riesgo ,Advanced maternal age ,Family history ,business - Abstract
Objetivo: identificar los factores asociados a la presencia de fisura labial y/o palatina en recién nacidos en el Hospital Nacional Edgardo Rebagliati Martins, localizado en Lima – Perú, durante el periodo noviembre 2012 - diciembre 2016. Materiales y métodos: estudio observacional, analítico, de casos y controles emparejado, con datos del Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAMC). Se analizaron 61 casos y 61 controles. La variable dependiente fue la presencia de fisura labial y/o palatina. Se recogieron también variables clínicas, epidemiológicas, obstétricas y prenatales. Resultados: la fisura labiopalatina con extensión completa, en el sexo masculino, fue la forma más frecuente y estuvo presente en 36 neonatos (59%), con cariotipo normal 44 (75,9%) y sin diagnóstico prenatal 40 (65,6%). Las malformaciones observadas con más frecuencia fueron las faciales 27 (44,2%) seguidas de malformaciones cardiacas (29,6%). Se construyó un modelo estadístico mediante análisis multivariado conformado por tres variables: enfermedad crónica durante el embarazo (odds ratio [OR]: 3,8; intervalo de confianza al 95% [IC 95%]: 1,11 - 13,08), edad materna mayor a 35 años (OR: 6,85; IC 95%: 2,69 - 17,43) y antecedente familiar (OR: 14,5; IC 95%: 1,68 - 125,56). Conclusiones: las enfermedades crónicas en el embarazo, la edad materna avanzada y el antecedente familiar fueron factores que aumentaron la presencia de fisura labial y/o palatina.
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- 2020
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33. MYT1 role in the microtia‐craniofacial microsomia spectrum
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Harry Pachajoa, Paula Hurtado-Villa, Paola Ayala-Ramírez, Natalia Jimenez, Andrew E. Timms, Carrie L. Heike, Lina Maria Ibañez, Milagros M. Dueñas-Roque, Gloria Liliana Porras-Hurtado, Daniela V Luquetti, Jonas A Gustafson, and Ignacio Zarante
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Male ,0301 basic medicine ,lcsh:QH426-470 ,030105 genetics & heredity ,Biology ,hemifacial microsomia ,Genetic analysis ,Clinical Reports ,DNA sequencing ,03 medical and health sciences ,symbols.namesake ,Goldenhar Syndrome ,Genotype-phenotype distinction ,medicine ,craniofacial microsomia ,Humans ,genetics ,oculo‐auriculo‐vertebral spectrum ,Child ,Molecular Biology ,Gene ,Genetics (clinical) ,Congenital Microtia ,Genetics ,Sanger sequencing ,Clinical Report ,Microtia ,Syndrome ,medicine.disease ,Hypoplasia ,DNA-Binding Proteins ,Hemifacial microsomia ,lcsh:Genetics ,030104 developmental biology ,Mutation ,symbols ,Female ,microtia ,Transcription Factors - Abstract
Background Craniofacial microsomia (CFM), also known as the oculo‐auriculo‐vertebral spectrum, comprises a variable phenotype with the most common features including microtia and mandibular hypoplasia on one or both sides, in addition to lateral oral clefts, epibulbar dermoids, cardiac, vertebral, and renal abnormalities. The etiology of CFM is largely unknown. The MYT1 gene has been reported as a candidate based in mutations found in three unrelated individuals. Additional patients with mutations in this gene are required to establish its causality. We present two individuals with CFM that have rare variants in MYT1 contributing to better understand the genotype and phenotype associated with mutations in this gene. Methods/Results We conducted genetic analysis using whole‐exome and ‐genome sequencing in 128 trios with CFM. Two novel MYT1 mutations were identified in two participants. Sanger sequencing was used to confirm these mutations. Conclusion We identified two additional individuals with CFM who carry rare variants in MYT1, further supporting the presumptive role of this gene in the CFM spectrum., We conducted genetic analysis using whole‐exome and ‐genome sequencing in 128 trios with CFM. Two novel MYT1 mutations were identified in two participants, further supporting the presumptive role of this gene in the CFM spectrum.
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- 2020
34. Genetics and genomics in Peru: Clinical and research perspective
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Milagros M. Dueñas-Roque, Eduardo Acevedo-Vásquez, Cesar Sanchez, Hugo Abarca-Barriga, Alejandro Piscoya, Luis Jaramillo-Valverde, Pilar Mazzetti, Julio A. Poterico, Gioconda Manassero-Morales, Manuel F. Ugarte-Gil, Yasser Sullcahuaman-Allende, Ricardo Fujita, Kelly S. Levano, Heinner Guio, Mario Cornejo-Olivas, Juan Manuel Iglesias-Pedraz, and Sandro Casavilca-Zambrano
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0301 basic medicine ,Genetics, Medical ,Genomics ,Genética humana ,genomic ,Translational Research, Biomedical ,Perú ,03 medical and health sciences ,0302 clinical medicine ,parasitic diseases ,Peru ,Genetics ,Humans ,Genetic Testing ,Molecular Biology ,Genoma ,Genetics (clinical) ,Field (Bourdieu) ,Perspective (graphical) ,Genetics and Genomic Medicine around the World ,030104 developmental biology ,Geography ,Human evolution ,Genomic ,genetic ,030217 neurology & neurosurgery ,geographic locations ,Facilities and Services Utilization - Abstract
Peru is a pluricultural and ethnically diverse country located in middle west of South America. It is the fourth largest country (1,285,216 km2) in area in South America, bordered in the north by Ecuador and Colombia, in the south by Chile, south east by Bolivia, by Brazil in the east and by the Pacific Ocean in the west. Peru has one of the most diverse climates, geographical and ecological in the world, from tropical or subtropical dessert to glacial in highland mountains to Amazon jungle. Peru is divided into 24 geopolitical regions with a central government. According to last national census in 2017, Peruvian populations accounts for 31,237,385 inhabitants (Instituto Nacional de Estadistica e Informatica [INEI], 2017). Most of Peru's population lives in the Coastal area, with almost one third of the nation's population living in Lima, the largest city with approximately 11 million people. Rural and urban population has changed over the last 50 years due to migration waves in the 1950s from rural to urban sites mainly located in the coast causing decrease or disappearance of native communities. Revisado por pares
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- 2018
35. V-030 - VÍDEO-CASO DE TERATOMA EN LA REGIÓN PINEAL EN UN ADULTO
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Barragan, A. Fernández, Carretero, M. Dueñas, Gutiérrez, M. López, Gómez, S. Santiño, González, J.A. Fernández, Angulo, C. Ortega, Muñoz, P. Cabrerizo, Frade, N. Porto, and Foncea, A.F. Molina
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- 2023
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36. P-052 - NUCLEOPLASTIA PERCUTÁNEA EN EL TRATAMIENTO DEL DOLOR DISCOGÉNICO LUMBAR
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Muñoz, P. Cabrerizo, Angulo, C. Ortega, Foncea, A.F. Molina, González, J.A. Fernández, Gómez, S. Santiño, Porto, N. Frade, Gutiérrez, M. López, Carretero, M. Dueñas, and Barragán, A. Fernández
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- 2023
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37. 8th International Week of Science, Technology & Innovation (8th IWSTI)
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B Medina Delgado, Velásquez Pérez, J E Torres-Ramírez, A Sandoval Amador, L M Dueñas, C A Calero, and E D V-Niño
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History ,Computer Science Applications ,Education - Abstract
The 8th International Week of Science, Technology, and Innovation (8th IWSTI) took place from 21 to 24 September de 2021, in the city of San José de Cúcuta, Colombia, and was organized by the Universidad Francisco de Paula Santander headquarters in San José de Cúcuta and Ocaña. The 8th IWSTI is aimed at the academic and scientific community and to the productive sectors of the region, and have a purpose are the dissemination of academic, and research works; moreover, promotes the exchange of experiences between researchers as well as the participation of the productive sectors in research, extension, technological development, and innovation activities for contribution to strengthening the relationship School-University-Company-State. The 8th IWSTI generated spaces for the exchange experiences academic and scientific in different knowledge areas between students, teachers, entrepreneurs, and researchers from the United States of America, Mexico, Argentina, Chile, Perú, Venezuela, and Colombia. Additionally, during the 8th IWSTI, was held the V Interinstitutional Conference of Research Seedbeds, which has as the main goal to socialize the research proposals and research results, obtained in different areas of knowledge, by the Research Seedbeds of all Educational Institutions of Norte de Santander, SIES+, Colombia. The organizing committee of the 8th IWSTI is extremely thankful to all participants for providing their valuable contributions as well as the reviewers for their recommendations and constructive criticism that help to improve the articles presented in this volume of proceedings. The articles refer to one of the following topics addressed in the 8th IWSTI: Modeling, Simulation, and Diagnostics, Physical-Mathematical Problems in Engineering, Characterization of Materials. Likewise, we like to thank the Universidad Francisco de Paula Santander (UFPS), and the Foundation of Researchers in Materials Science and Technology (FORISTOM), for all the support technical and logistical received. Finally, the editor hopes that those interested in the area of research, technology, and innovation in sciences and engineering will enjoy reading this volume of the Journal of Physics: Conference Series (JPCS), which reflects a wide variety of current issues, contributing to the generation and transfer of knowledge, as well as to the strengthening of research in science and engineering in Colombia. “Education and expression freedom for anyone”. List of Organizing Committee, National Scientific Committee, International Scientific Committee, Logistic, Sponsor, Partners are available in this pdf.
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- 2021
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38. 1st International Conference on Physical Problems of Engineering (1st ICPPE)
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J Barba-Ortega, L M Dueñas, J C Ruge, E D V-Niño, and J E Torres-Ramírez
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History ,Computer Science Applications ,Education - Abstract
The reciprocal contribution that physics has had in engineering and engineering in physics is undeniable. The First International Conference on Physical Problems of Engineering (1st ICPPE) tries to highlight this symbiotic relationship between both sciences through different presentations that reflected their results in separate articles that will be published in the Journal of Physics: Conference Series. List of Organizing Committee, National Scientific Committee, International Scientific Committee, Sponsor, Partners, Images are available in this pdf.
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- 2021
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39. Predicting academic achievement in adolescents: The role of maturity, intelligence and personality
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Fabia, Morales-Vives, Elisa, Camps, and Jorge M, Dueñas
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Male ,Academic Success ,Adolescent ,Consciousness ,Intelligence ,Psychology, Adolescent ,Personality Assessment ,Sex Factors ,Attitude ,Socioeconomic Factors ,Spain ,Humans ,Regression Analysis ,Female ,Personality - Abstract
Very few studies have examined whether the degree of adolescents' maturity has any effect on their academic performance. Moreover, there are no studies that show whether maturity explains variance additional to that explained by intelligence and personality. For this reason, the main aim of the current study was to determine how psychological maturity, the Big Five personality traits and mental aptitudes contribute to the prediction of adolescent academic performance.305 adolescents took part in the study. We performed correlations, multiple regression analysis and structural equation analysis.As expected, results show that the main predictor is intelligence. The results also show that there is a relationship between psychological maturity and academic performance, although this is due only to the work orientation subscale. Moreover, conscientiousness influences academic performance because of its relation to the maturity factor work orientation. Likewise, openness to experience is also indirectly related to academic performance, due to its relationship with intelligence.The results of the current study suggest that psychological maturity is related to academic performance. Only two personality traits are correlated to academic performance, conscientiousness and openness to experience, although these traits do not have direct relationships with academic performance.
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- 2020
40. Novel mutation in ENG gene causing Hereditary Hemorrhagic Telangiectasia in a Peruvian family
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Ana Protzel, Ada Chávez-Gil, María Luisa Guevara-Fujita, Luis Venegas-Tresierra, Milagros M. Dueñas-Roque, Alexis Murillo, Verónica Ángeles-Villalba, Alejandro Zevallos-Morales, Ricardo Fujita, and Miguel Guevara-Cruz
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0106 biological sciences ,0301 basic medicine ,Telangiectasia hemorrágica hereditaria ,QH426-470 ,Biology ,01 natural sciences ,03 medical and health sciences ,Exon ,Perú ,Genetics ,medicine ,Missense mutation ,Normal protein ,Telangiectasia ,Molecular Biology ,Gene ,Hereditary Hemorrhagic Telangiectasia ,Mutación ,ACVRL1 gene ,ENG ,030104 developmental biology ,Human and Medical Genetics ,Mutation (genetic algorithm) ,Familia ,medicine.symptom ,Osler-Weber-Rendu disease ,Novel mutation ,010606 plant biology & botany - Abstract
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder of vascular development. Common manifestations include epistaxis, telangiectasias and arteriovenous malformations (AVMs) in multiple organs. Most patients have deletions or missense mutations in the ENG or ACVRL1 gene respectively, significantly affecting endothelium homeostasis. We analyzed the ENG gene in five members of a Peruvian family affected by HHT. One novel mutation was found in exon four of the ENG gene c.408delA, at aminoacid residue 136. This mutation changes the subsequent reading frame producing an early stop at residue 162, preserving only one fourth of the normal protein of 658 aa. This mutation was found in the four affected members of family.
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- 2020
41. Turner syndrome in diverse populations
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Joanna Y.L. Tung, Katta M. Girisha, Paul Kruszka, Nicole Fleischer, Engy A. Ashaat, E.V. Badoe, Dalia Farouk Hussen, Neer Shoba Chitrakar, Angélica Moresco, Neveen A. Ashaat, Olufemi Fasanmade, Siddaramappa J. Patil, Mona O. El Ruby, André Mégarbané, Johnathan Watts, Karen Fieggen, Gary T. K. Mok, Dhanya Yesodharan, Milagros M. Dueñas-Roque, Ezana Lulseged, Cedrik Tekendo-Ngongang, Sarah Savage, Saumya Shekhar Jamuar, Vajira H. W. Dissanayake, Nirmala D. Sirisena, Sultana M.H. Faradz, Antonio Richieri-Costa, Kelly L. Jones, Jasmine Chew Yin Goh, Brenda C. Iriele, María Beatriz de Herreros, Brian H.Y. Chung, Godfrey Mutashambara Rwegerera, María Gabriela Obregon, Yonit A. Addissie, Nydia Rena Benita Sihombing, Teresa Aravena, Shubha R. Phadke, Victoria Huckstadt, C. Sampath Paththinige, Meow-Keong Thong, Neerja Gupta, Agustini Utari, Sheela Nampoothiri, Elizabeth Eberechi Oyenusi, Ekanem N. Ekure, Maximilian Muenke, Rupesh Mishra, Oluwarotimi Bolaji Olopade, Annette Uwineza, Vorasuk Shotelersuk, and Ambroise Wonkam
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Population ,Cubitus valgus ,Turner Syndrome ,Physical examination ,Short stature ,Article ,White People ,Young Adult ,Asian People ,Turner syndrome ,Genetics ,medicine ,Humans ,Abnormalities, Multiple ,SÍNDROME DE NOONAN ,Child ,education ,Genetics (clinical) ,X chromosome ,Chromosomes, Human, X ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Noonan Syndrome ,Infant, Newborn ,Area under the curve ,Infant ,Hispanic or Latino ,Middle Aged ,medicine.disease ,Phenotype ,Child, Preschool ,Face ,Population Surveillance ,Noonan syndrome ,Female ,medicine.symptom ,business ,Facial Recognition - Abstract
Turner syndrome (TS) is a common multiple congenital anomaly syndrome resulting from complete or partial absence of the second X chromosome. TS presents with short stature, infertility secondary to ovarian dysgenesis, cardiac and renal anomalies, characteristic exam findings such as cubitus valgus, normal intelligence, and specific neurocognitive profile which includes visual spacial deficits and math difficulties. Clinical studies of TS have predominantly focused on individuals of European descent. In this study, we explore the phenotype of TS in diverse populations using clinical examination and facial analysis technology. Clinical data from 70 individuals and images from 108 individuals with TS from 18 different countries were analyzed. Individuals were grouped into categories of African descent (African), Asian, Latin American, Caucasian (European descent), and Middle Eastern. The most common phenotype features across all population groups were short stature (85%), cubitus valgus (77%) and, low posterior hair line 70%. Other phenotype features found in over half included small mandible (63%), narrow hyperconvex and deep set fingernails (56%), narrow maxilla (53%), and short fourth metacarpals (50%). Congenital heart disease was found in 32% of the cohort. Two facial analysis technology experiments were conducted: TS vs. general population and TS vs. Noonan syndrome. Across all ethnicities, facial analysis was very accurate in diagnosing TS from frontal facial images as measured by the area under the curve (AUC). An AUC of 0.903 (p
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- 2020
42. Preface
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M Vergel-Ortega, O L Rincón Leal, and L M Dueñas Ramírez
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History ,ComputingMilieux_COMPUTERSANDEDUCATION ,Computer Science Applications ,Education - Abstract
V International Meeting of Mathematical Education The objective of the V International Meeting on Mathematics Education (V IMME) is to create and maintain a space that privileges and promotes the culture of mathematics, reflection and discussion on the education and application of mathematics, statistics, its history, evolution and didactics, and its interrelation with the sciences. At the meeting, researchers, scientists, and mathematics teachers socialize the results of research, consolidate networks for the exchange of successful experiences, to strengthen mathematics education at different educational levels, promote innovation and encourage the creation of policies, models, educational strategies, tools, and techniques in various areas of mathematics. They also promote innovation and encourage the creation of policies, models, educational strategies, tools and techniques in different areas of knowledge, and foster students' interest in research. V International Meeting of Mathematical Education, Organizing Committee, International Scientist Committee, International Scientific Committee, Invited Speakers are available in this pdf.
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- 2021
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43. Factors influencing growth, sporulation and virus transfer in Cryphonectria parasitica isolates from Castilla and León (Spain)
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Julio J. Diez, A. González Casas, Pablo Zamora, R. San Martín, and M. Dueñas
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0106 biological sciences ,0301 basic medicine ,biology ,Host (biology) ,fungi ,Virulence ,Plant Science ,Horticulture ,biology.organism_classification ,01 natural sciences ,Virology ,Virus ,Conidium ,Microbiology ,03 medical and health sciences ,030104 developmental biology ,Chestnut blight ,Cryphonectria ,Hypovirus ,Agronomy and Crop Science ,Horizontal transmission ,010606 plant biology & botany - Abstract
Biological control with Cryphonectria hypovirus CHV1 of the chestnut blight, caused by the fungus Cryphonectria parasitica, has reduced the impact of the disease in Europe. The virus reduces the virulence of the fungus so that it causes non-lethal cankers, thus enabling the chestnut trees to overcome the disease. The virus can be transmitted horizontally by hyphal anastomosis or vertically to the conidia. In this study, we investigated growth and sporulation of the fungus as well as rates of horizontal transmission of the virus at different temperatures. We used fungal isolates of the vegetative compatibility types (vc types) that are most prevalent in Castilla and Leon (central northern Spain) to evaluate the effects of fungal strain on the parameters tested. In addition, we infected four isolates of C. parasitica with hypovirus subtypes CHV1-F1 and CHV1-I, to determine the influence of virus subtype on growth, sporulation and virus transfer. We assessed growth of fungal colonies and horizontal transmission of the virus at 15 °C and 25 °C. Colony growth was affected by an interaction between fungal isolates included in vc type EU1 or EU11 and virus at both 15 °C and 25 °C. However, horizontal transmission of the virus was only influenced by the fungal genotype of isolates included in vc type EU1 or EU11, and spore production was only affected by the virus subtype. Vertical transmission was also influenced by the fungal isolate and virus subtype. Growth of the fungal isolates varied depending on the virus subtype with which they were infected. This supports the theory that fungal host and virus subtype influence transmission and dissemination of hypovirulence. The fungal genotype affects colony growth and horizontal transmission of the virus. It is common to expect a good dissemination of the hypovirus with a low vc type diversity but the selection of the best combination of hypovirus and fungal isolate is crucial for the success of biological control not only for small areas but in larger chestnut populations as well.
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- 2016
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44. Evaluación de propiedades fisicoquímicas de aceite de girasol (Helianthus annuus) adicionado con extracto de achiote (Bixa orellana) durante calentamiento en horno microondas
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Obradith Caicedo, Yenny M. Dueñas, Arjuna Castrillón, and Julie Naranjo
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aceite de girasol ,calidad de los alimentos ,lcsh:Public aspects of medicine ,grasas ,Bixa orellana ,Helianthus annuus ,lcsh:TX341-641 ,lcsh:RA1-1270 ,microondas ,lcsh:Nutrition. Foods and food supply - Abstract
Antecedentes : la coccion de alimentos en horno microondas es una tendencia en aumento en la poblacion en general, sin que se tenga en cuenta el efecto sobre su calidad. Objetivo : evaluar el efecto del extracto de Bixa orellana sobre aceite de girasol durante el calentamiento en microondas. Materiales y metodos : aceite de girasol, con y sin la adicion de extracto de Bixa orellana 100 ppm, se sometio a calentamiento durante 12 minutos en horno microondas evaluandose sus propiedades fisicoquimicas a distintos intervalos de tiempo. Resultados : la adicion de Bixa orellana contribuye a conservar la calidad del aceite de girasol sometido al microondas durante los tres primeros minutos de calentamiento. A tiempos mayores, dadas las temperaturas alcanzadas, no se observa efecto protector. Conclusion : la adicion de 100 ppm de extracto de Bixa orellana en aceite de girasol permite contrarrestar la oxidacion durante tres minutos de calentamiento en microondas.
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- 2016
45. 7th International Week of Science, Technology and Innovation (VII IWSTI)
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L. M. Dueñas Ramírez, T. Velásquez-Pérez, J. P. Rojas Suarez, and E. D. V-Niño
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History ,Computer Science Applications ,Education - Abstract
The 7th International Week of Science, Technology, and Innovation (7th IWSTI), which took place from 6 to 9 October de 2020, in the city of San José de Cúcuta, Colombia, and was organized by the Universidad Francisco de Paula Santander headquarters in San José de Cúcuta and Ocaña. The 7th IWSTI conference is aimed at the academic and scientific community and to the productive sectors of the region, and have a purpose are the dissemination of academic, and research works; moreover, promotes the exchange of experiences between researchers as well as the participation of the productive sectors in research, extension, technological development, and innovation activities for contribution to strengthening the relationship University-Company-State. The 7th International Week of Science, Technology, and Innovation (7th IWSTI) generated spaces for the exchange experiences academic and scientific in different knowledge areas between students, teachers, entrepreneurs, and researchers from Belgium, Spain, Mexico, Puerto Rico, Brazil, and Colombia. Additionally, during the 7th IWSTI, was held the IV Interinstitutional Conference of Research Seedbeds of the Alliance of Higher Education Institutions SIES+ is held; the main goal of this meeting was to socialize the research proposals and research results, obtained in different areas of knowledge, by the Research Seedbeds of the Educational Institutions of Norte de Santander, SIES+, Colombia. List of Organizing Committee, International Scientific Committee, National Scientific Committee, Logistics Committee, Sponsors and Partners are available in this pdf.
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- 2020
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46. XIV International Congress of Electronics and Advanced Technologies
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A. Pardo García, L. M. Dueñas Ramírez, and E. D. V-Niño
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History ,Engineering ,business.industry ,International congress ,Electronics ,Telecommunications ,business ,Computer Science Applications ,Education - Abstract
The Universidad de Pamplona, Colombia, through its Faculty of Engineering and Architecture, realized the XIV International Congress of Engineering “Electronics and Advanced Technologies” (XIV CIETA), X International Congress on Systems, Informatics, and Knowledge Engineering (CICOM), X International Congress on Telecommunications, IX International Congress on Electrical Engineering, V International Congress of Mechatronics Engineering and II International Congress of Industrial Engineering, Virtual modality in Pamplona, Norte de Santander, Colombia, on October 28, 29 and 30 of the year 2020. This International Congress “Electronics and Advanced Technologies” is a point of contact between the college students, engineers and researchers as much from the Universidad de Pamplona as from other foreign Universities or of Colombia. The International Congress “Electronics and Advanced Technologies” proposes general and specialized articles and discusses topics such as Physics, Mathematics, Automatic Control, Automatization, Digital signal Processing, Electronics, Electrical treat, Telecommunications, Systems, and areas related to sciences and engineering. List of Organizing Committee, International Scientific Committee, National Scientific Committee, Local Scientific Committee, Logistics Committee, Sponsor and Partners are available in this pdf.
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- 2020
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47. III Workshop on Modeling and Simulation for Science and Engineering
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A Sandoval-Amador, L M Dueñas-Ramírez, and E D V-Niño
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History ,Computer Science Applications ,Education - Abstract
The III Workshop on Modeling and Simulation for Science and Engineering (III WMSSE) is an academic event that aims to highlight the close links between basic sciences, especially mathematics, and their implementation in engineering. During the event, which will be held in the city of Armenia, Colombia, talks in areas such Mathematical Physics, Computational Science, Dynamic Systems Model, Mechatronic Systems, Chemical Physics, and Physical Chemistry, Education and Communication is presented; moreover, courses in metaheuristics, financial market analysis, and software management is offered. List of Organizing Committee, National Scientific Committee, Sponsor Partners are available in the pdf.
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- 2020
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48. IV International Meeting of Mathematical Education
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L M Dueñas Ramírez, H. M. Parra-López, and M Vergel-Ortega
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History ,Computer Science Applications ,Education - Abstract
Sharing the motto “Mathematics is Everywhere” and its icon “The crane” symbolizes honesty, maturity, the judgment that ensures the growth of all in spite of unseasonable winds and integrity, the objective of the IV International Meeting on Mathematics Education (IV IMME) is to create and maintain a space that privileges and promotes the culture of mathematics, reflection, and discussion on education and the application of mathematics, statistics, its history, evolution and didactics, and its interrelationship with science. At the meeting, researchers, scientists, and mathematics teachers socialize research results, consolidate networks for the exchange of successful experiences, with the purpose of strengthening mathematics education at different educational levels, promoting innovation, and fostering the creation of educational policies, models, strategies, tools and techniques, in various areas of knowledge and encouraging students’ interest in research. List of Organizing Committee International Scientist Committee National Scientific Committee are available in the pdf.
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- 2020
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49. XV Applied Mathematics Meeting and XII Statistics Meeting
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C. S. Gómez-Vergel, H. M. Parra-López, J. P. Rojas-Suárez, and L. M. Dueñas Ramírez
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History ,Engineering ,business.industry ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,business ,Computer Science Applications ,Education - Abstract
The objective of the XV Applied Mathematics Meeting and XII Statistics Meeting was to promote a space for the exchange of knowledge between the academic and industrial sectors and physics; this event is a space to promote reflection and debate on mathematics, statistics, its history, evolution, didactics and application in physics and other sciences. In this meeting, researchers and teachers of mathematics interacted, socialized research results, consolidated networks for the exchange of ideas and successful experiences; moreover, these spaces allowed the strengthening of mathematics and statistics as a science. This science with its pedagogical principles promoted innovation and encouraged the creation of other learning scenarios; these scenarios are oriented to the application of mathematics in various areas of knowledge and to encourage students’ interest in research in these sciences. List o Organizing Committee, National Scientific Committee, International Scientific Committee, Invited Speakers, Sponsor and Sponsor logos, Partners and Partners logos are also available in this pdf.
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- 2020
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50. Application of virtual technologies for the representation of physical phenomena in maintenance tasks
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C P Chamat Torres, G. A. Villegas López, and L. M. Dueñas Ramírez
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History ,Computer science ,Human–computer interaction ,Physical phenomena ,Representation (systemics) ,Computer Science Applications ,Education - Abstract
Maintenance during industrial development has evolved, always seeking the in-depth study of the physical phenomena that occur in the elements and systems that have suffered functional failures. Maintenance has been adapted to each challenge presented. The progress and development of computer science have opted for the massive use of information and communication technologies that support industrial processes, generating new possibilities in maintenance management and operation. These tools could contribute to improving the efficiency of maintenance processes, taking into account that these costs represent a third of the total production cost in an organization. This work seeks to identify the evolution of these technological tools in the applications that they have had in representing the physical phenomena of maintenance management. This research also seeks to establish the minimum requirements that these tools must consider in their applications and uses. Considering the appropriation of these technologies in Colombia, in order to determine where the country is in terms of development and technological use, being important information for the recognition of the scenario and decision-making that prevail in a competitive Colombian industry world level.
- Published
- 2020
- Full Text
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