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1. Long-term impact of Diabetes Prevention Program interventions on walking endurance

Author: Medha N. Munshi, Elizabeth M. Venditti, Ashley H. Tjaden, William C. Knowler, Edward J. Boyko, Roeland J. W. Middelbeek, José A. Luchsinger, Christine G. Lee, Helen P. Hazuda, Marcel E. Salive, Sharon L. Edelstein, and Thomas W. Storer
Subjects: diabetes, walking endurance, aging, six-minute walk test, lifestyle, Public aspects of medicine, RA1-1270
Abstract: ObjectivesType 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. We aimed to examine the long-term effects of metformin or intensive lifestyle intervention in adults at high risk of T2D on their 6-min walk test (6MWT) performance.MethodsParticipants were randomized in the 3-year Diabetes Prevention Program (DPP) to one of the three groups: lifestyle intervention, metformin, or placebo, and were subsequently followed in the DPP Outcomes Study. A 6MWT was conducted 20 years after randomization. Associations between DPP interventions and 6MWT completion (achieving a distance ≥200 m) were assessed using logistic regression. Among the test completers, differences in distance walked (6MWD) were evaluated using multivariable linear regression. Additional variables of interest included concomitant measures of body mass index (BMI) and grip strength along with mean measures of HbA1c and self-reported physical activity (PA).ResultsData on 1830 participants were analyzed. The interventions were not associated with test completion or the 6MWD among test completers (362, 364, and 360 m in the lifestyle, metformin, and placebo groups, respectively, p = 0.8). Age, education, grip strength, and PA were each significantly associated with the 6MWT completion and the 6MWD after adjustment. Grip strength, PA, and education were positively associated with the 6MWD, while age, BMI, and HbA1c were negatively associated with the 6MWD.ConclusionWe confirmed that the 6MWT is related to other measures of physical ability such as PA and grip strength in persons at risk for and with T2D, suggesting potential long-term benefits of maintaining a healthy lifestyle. However, we did not observe a sustained effect of the original randomized interventions.Clinical trial registrationhttp://www.clinicaltrials.gov/ct/show/NCT00004992, identifier DPP NCT00004992; http://www.clinicaltrials.gov/ct/show/NCT00038727, identifier DPPOS NCT00038727
Published: 2024
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2. Examining paradoxical session attendance and weight loss relationships in a clinic based lifestyle modification intervention

Author: Kristen M. J. Azar, Sylvia Sudat, Qiwen Huang, Alice P. Pressman, Nina K. Szwerinski, Catherine Nasrallah, Elizabeth M. Venditti, and Robert J. Romanelli
Subjects: diabetes mellitus, health education, lifestyle change, obesity, program effectiveness, type 2 diabetes, Internal medicine, RC31-1245
Abstract: Abstract Objective Evaluations of lifestyle modification interventions (LMIs), modeled after the Diabetes Prevention Program, have repeatedly shown a dose‐response relationship between session attendance and weight loss. Despite this, not all participants had “average” weight loss experiences. Nearly one‐third of LMI participants experienced unexpected, paradoxical outcomes (i.e., high attendance with little weight loss, and low attendance with clinically significant weight loss). Paradoxical weight‐loss outcomes were characterized based on session attendance among participants in a group‐based LMI in a real‐world healthcare setting. This group‐based LMI was delivered over 1 year to participants with the possibility of attending up to 25 sessions total. Methods LMI participants identified in 2010–2017 from electronic health records were characterized as having low (
Published: 2023
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3. Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae: Analysis of cases and evaluation of in vitro activity of fosfomycin-containing combinations

Author: A. Oliva, D. Al Ismail, G. Arcari, MC. Miele, E. Casali, F. Sacco, L. Volpicelli, M. De Angelis, M.T. Mascellino, F. Cancelli, G. Raponi, A. Carattoli, and M Venditti
Subjects: Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae KPC-variant, Fosfomycin, Synergism, Carbapenems, Meropenem/vaborbactam, Microbiology, QR1-502
Abstract: ABSTRACT: Objectives: Little is known regarding outcomes and optimal therapeutic regimens of infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) resistant to ceftazidime/avibactam (CZA) and susceptible to meropenem (MEM). Although susceptible to MEM in vitro, the possibility of developing MEM resistance overtime is a concern. We describe the clinical characteristics of patients with colonization/infection due to KPC variants with a focus on the in vitro activity of fosfomycin (FOS)-containing combinations. Methods: Patients with colonization/infection due to a KPC variant were included. Fosfomycin susceptibility was performed by agar dilution method. Synergistic activity of FOS-based combinations was evaluated by gradient strip-agar diffusion method. The emergence of in vitro MEM resistance was also tested. Results: Eleven patients were included: eight with infection [four with ventilator-associated pneumonia and four with bloodstream infections] and three with colonization. Previous therapy with CZA was administered to all patients (with a mean cumulative duration of 23 days). All subjects with infection received meropenem, in monotherapy (n = 4) or with amikacin (n = 2) or fosfomycin (n = 2), and achieved clinical cure. A new CZA-susceptible and MEM-resistant KPC-Kp strain was subsequently isolated in three patients (27.3%). Meropenem/vaborbactam (MVB) showed high in vitro activity, while FOS+MEM combination was synergistic in 40% of cases. In vitro resistance to MEM was observed with maintenance of CZA resistance. Conclusions: Detection of KPC variants may occur within the same patient, especially if CZA has been previously administered. Although clinical success has been obtained with carbapenems, the emergence of MEM resistance is a concern. Fosfomycin plus meropenem is synergistic and may be a valuable combination option for KPC variants, while MVB may be considered in monotherapy. The detection of KPC variants in an endemic setting for KPC-Kp represents a worryingly emerging condition. The optimal therapeutic approach is still unknown and the development of meropenem resistance is of concern, which may lead to therapeutic failure in clinical practice. In these cases, the addition of fosfomycin to meropenem, or a more potent antibiotic, such as meropenem/vaborbactam, may be valuable therapeutic options.
Published: 2023
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4. The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS)

Author: Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, and DPP Research Group
Subjects: Alcohol, Diet, Disease prevention, Obesity, Physical activity, Weight, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920
Abstract: Abstract Background The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that aligns with the recommendations – assessed via the 2018 WCRF/AICR Score – was associated with lower risk of type 2 diabetes in high-risk adults participating in the Diabetes Prevention Program Outcomes Study (DPPOS). Methods The Diabetes Prevention Program (DPP) randomized adults at high risk for diabetes to receive a lifestyle intervention (ILS), metformin (MET) or a placebo (PLB) (mean: 3.2 years), with additional follow-up in DPPOS for 11 years (mean: 15 years total). 2018 WCRF/AICR Scores included seven components: body weight, physical activity, plant-based foods, fast foods, red and processed meat, sugar-sweetened beverages, and alcohol; the optional breastfeeding component was excluded. Scores ranged 0-7 points (with greater scores indicating greater alignment with the recommendations) and were estimated at years 0, 1, 5, 6, 9, and 15 (N=3,147). Fasting glucose and HbA1c were measured every six months and oral glucose tolerance tests were performed annually. Adjusted Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were used to examine the association of both Score changes from years 0-1 and time-dependent Score changes on diabetes risk through DPP and year 15. Results Scores improved within all groups over 15 years (p
Published: 2022
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5. Effectiveness of a behavioral lifestyle intervention on weight management and mobility improvement in older informal caregivers: a secondary data analysis

Author: Xinran Liu, Jennifer King, Brandi Boak, Michelle E. Danielson, Robert M. Boudreau, Anne B. Newman, Elizabeth M. Venditti, and Steven M. Albert
Subjects: Caregiver, Aged, Weight loss programs, Health promotion, Healthy lifestyle, Exercise, Geriatrics, RC952-954.6
Abstract: Abstract Background Older informal caregivers are prone to sedentary behavior and obesity. With great caregiving burdens and frequent physical and mental distress, older informal caregivers may have low adherence and poor results in behavioral intervention for weight management. This study examined whether overweight or obese older informal caregivers could benefit from a behavioral weight management program as much as non-caregivers. Methods The Mobility and Vitality Lifestyle Program (MOVE UP) was a pre-post, community-based, 13-month lifestyle intervention study to help older adults improve physical function performance and lose weight. We identified a subset of informal caregivers (n = 29) and non-caregivers (n = 65) from the MOVE UP participants retrospectively. Changes in lower extremity function, weight, depressive symptoms, and self-efficacy from baseline were compared between caregivers and non-caregivers using paired t-tests and ANCOVA. Results Older informal caregivers had significantly lower session attendance rates than non-caregivers (67.7% vs 76.8%, P
Published: 2022
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6. Diet quality, weight loss, and diabetes incidence in the Diabetes Prevention Program (DPP)

Author: Benjamin T. Allaire, Ashley H. Tjaden, Elizabeth M. Venditti, John W. Apolzan, Dana Dabelea, Linda M. Delahanty, Sharon L. Edelstein, Mary A. Hoskin, Karla A. Temple, Judith Wylie-Rosett, Lindsay M. Jaacks, and DPP Research Group
Subjects: AHEI, Body weight, DPP, Prediabetes, Type 2 diabetes, Lifestyle intervention, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920
Abstract: Abstract Background We evaluated whether diet quality is a predictor of weight loss and reduced diabetes risk, independent of caloric intake in the Diabetes Prevention Program (DPP) cohort, a randomized clinical trial of adults at risk for diabetes. Methods This secondary analysis included 2914 participants with available data (964 intensive lifestyle (ILS), 977 metformin, 973 placebo). Dietary intake was assessed using a 117-item food frequency questionnaire. Diet quality was quantified using the Alternative Healthy Eating Index 2010 (AHEI). AHEI ranges from 0 to 110, with higher scores corresponding to higher quality diets. ILS participants had greater improvement (p
Published: 2020
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7. Preferences for Technology-Mediated Behavioral Lifestyle Interventions With Different Levels of Coach and Peer Support Among Latino Men: Comparative Study Within One Arm of a Randomized Controlled Trial

Author: Lisa G Rosas, Nan Lv, Lan Xiao, Kristen MJ Azar, Steven P Hooker, Elizabeth M Venditti, Megan A Lewis, Patricia Zavella, and Jun Ma
Subjects: Medicine
Abstract: BackgroundAlthough Latino men have the highest prevalence (45%) of obesity among all men in the United States, traditional weight loss interventions have not effectively engaged this hard-to-reach and diverse group. Offering choices among technology-mediated weight loss interventions may offer advantages. ObjectiveThe aim of this study is to examine Latino men’s preferences among 3 weight loss intervention options. We also examined whether attendance in group sessions (videoconference and in person) and weight loss differed according to intervention choice. MethodsLatino men (n=200; mean age 47.3, SD 11.8 years) participated in a comparative effectiveness trial based on primary care and were randomized to receive the 1-year HOMBRE (Hombres con Opciones para Mejorar su Bienestar para Reducir Enfermedades Crónicas; English translation: Men With Options to Improve Their Well-being and Reduce Chronic Disease) intervention. HOMBRE is a weight loss intervention that offers 3 delivery options. During an orientation session, a trained bilingual coach helped men select 1 of the 3 intervention options that differed in coach, peer support, and available language. We used canonical discriminant analysis to assess multivariate associations of demographic, clinical, employment, cultural, and technology use and access factors with men’s intervention choices. We used generalized linear models to estimate weight loss at 6, 12, and 18 months for men in each intervention option. ResultsAmong Latino men, 28% (56/200) chose videoconference groups, 31% (62/200) chose web-based videos, and 41% (82/200) chose in-person groups. The canonical discriminant analysis identified 1 orthogonal dimension that distinguished between men who chose an in-person group and men who chose web-based videos. Men who were older, spoke Spanish, and did not use a computer frequently had a higher probability of choosing in-person groups versus web-based videos. For men who selected a group delivery option, 86.9% (107/123) attended ≥25% of the sessions, 83.7% (103/123) attended ≥50% of the sessions, and 73.2% (90/123) attended ≥75% of the sessions, with no differences by type of group (videoconference or in person). Men who chose videoconference and in-person group sessions lost significantly more weight at 6 months (both P
Published: 2022
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8. Habitat differentiation among three Nigeria–Cameroon chimpanzee (Pan troglodytes ellioti) populations

Author: Ekwoge E. Abwe, Bethan J. Morgan, Barthelemy Tchiengue, Fabrice Kentatchime, Roger Doudja, Marcel E. Ketchen, Eric Teguia, Ruffin Ambahe, Dana M. Venditti, Matthew W. Mitchell, Bernard Fosso, Albert Mounga, Roger C. Fotso, and Mary Katherine Gonder
Subjects: ecological niche models, ecotone, ground‐truthing, human‐modified landscape, rainforest, Ecology, QH540-549.5
Abstract: Abstract Ecological niche models (ENMs) are often used to predict species distribution patterns from datasets that describe abiotic and biotic factors at coarse spatial scales. Ground‐truthing ENMs provide important information about how these factors relate to species‐specific requirements at a scale that is biologically relevant for the species. Chimpanzees are territorial and have a predominantly frugivorous diet. The spatial and temporal variation in fruit availability for different chimpanzee populations is thus crucial, but rarely depicted in ENMs. The genetic and geographic distinction within Nigeria–Cameroon chimpanzee (Pan troglodytes ellioti) populations represents a unique opportunity to understand fine scale species‐relevant ecological variation in relation to ENMs. In Cameroon, P. t. ellioti is composed of two genetically distinct populations that occupy different niches: rainforests in western Cameroon and forest–woodland–savanna mosaic (ecotone) in central Cameroon. We investigated habitat variation at three representative sites using chimpanzee‐relevant environmental variables, including fruit availability, to assess how these variables distinguish these niches from one another. Contrary to the assumption of most ENM studies that intact forest is essential for the survival of chimpanzees, we hypothesized that the ecotone and human‐modified habitats in Cameroon have sufficient resources to sustain large chimpanzee populations. Rainfall, and the diversity, density, and size of trees were higher at the rainforest. The ecotone had a higher density of terrestrial herbs and lianas. Fruit availability was higher at Ganga (ecotone) than at Bekob and Njuma. Seasonal variation in fruit availability was highest at Ganga, and periods of fruit scarcity were longer than at the rainforest sites. Introduced and secondary forest species linked with anthropogenic modification were common at Bekob, which reduced seasonality in fruit availability. Our findings highlight the value of incorporating fine scale species‐relevant ecological data to create more realistic models, which have implications for local conservation planning efforts.
Published: 2019
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9. Early changes in neural circuit function engaged by negative emotion and modified by behavioural intervention are associated with depression and problem-solving outcomes: A report from the ENGAGE randomized controlled trial

Author: Andrea N Goldstein-Piekarski, Joseph Wielgosz, Lan Xiao, Patrick Stetz, Carlos G. Correa, Sarah E. Chang, Nan Lv, Lisa G. Rosas, Philip W. Lavori, Mark B. Snowden, Elizabeth M. Venditti, Janine M. Simmons, Joshua M. Smyth, Trisha Suppes, Megan A. Lewis, Olusola Ajilore, Jun Ma, and Leanne M. Williams
Subjects: Depression, Obesity, Insula, Amygdala, Problem-solving, Neuroimaging, Medicine, Medicine (General), R5-920
Abstract: Background: Depression exerts a staggering toll that is worsened with co-occurring chronic conditions such as obesity. It is imperative to develop more effective interventions for depression and to identify objective and biological plausible neural mechanisms to understand intervention outcomes. The current study uses functional neuroimaging to determine whether a behavioural intervention changes the negative affect circuit and whether these changes relate to subsequent improvements in both symptom and problem-solving outcomes in depressed patients with co-occurring obesity. Methods: This study (‘ENGAGE’) was a pre-planned element of the randomized controlled trial, ‘RAINBOW’ (ClinicalTrials.gov NCT02246413). 108 depressed patients with obesity were randomized to receive an integrated collaborative care intervention (I-CARE) or usual care. Participants underwent functional neuroimaging using an established facial emotion task at baseline and two months (coinciding with the first two months of intervention focused on problem-solving therapy (‘PST’)). Amygdala, insula and anterior cingulate cortex activation was extracted using pre-planned definitions and standardized methods. The primary health and behavioural outcomes were depression symptom severity and problem-solving ability respectively, assessed at baseline, the main 6-month outcome point and at 12-month follow up. Mediation analyses used an intent-to-treat approach. Findings: PST, relative to usual care, reduced amygdala activation engaged by threat stimuli at two months. This reduction mediated subsequent improvements in depression severity in an intervention-dependent manner. PST did not change insula activation at two months but did temper the strength of the relationship between insula activation and improvements in problem-solving ability. Interpretation: The negative affect circuit may be an important neural target and potential mediator of PST in patients with comorbid obesity. Funding: US National Institutes of Health/National Heart Lung and Blood Institute R01 HL119453 and UH2/UH3 HL132368
Published: 2021
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10. Using RE-AIM to examine the potential public health impact of an integrated collaborative care intervention for weight and depression management in primary care: Results from the RAINBOW trial.

Author: Megan A Lewis, Laura K Wagner, Lisa G Rosas, Nan Lv, Elizabeth M Venditti, Lesley E Steinman, Bryan J Weiner, Jeremy D Goldhaber-Fiebert, Mark B Snowden, and Jun Ma
Subjects: Medicine, Science
Abstract: BackgroundAn integrated collaborative care intervention was used to treat primary care patients with comorbid obesity and depression in a randomized clinical trial. To increase wider uptake and dissemination, information is needed on translational potential.MethodsThe trial collected longitudinal, qualitative data at baseline, 6 months (end of intensive treatment), 12 months (end of maintenance treatment), and 24 months (end of follow-up). Semi-structured interviews (n = 142) were conducted with 54 out of 409 randomly selected trial participants and 37 other stakeholders, such as recruitment staff, intervention staff, and clinicians. Using a Framework Analysis approach, we examined themes across time and stakeholder groups according to the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework.ResultsAt baseline, participants and other stakeholders reported being skeptical of the collaborative care approach related to some RE-AIM dimensions. However, over time they indicated greater confidence regarding the potential for future public health impact. They also provided information on barriers and actionable information to enhance program reach, effectiveness, adoption, implementation, and maintenance.ConclusionsRE-AIM provided a useful framework for understanding how to increase the impact of a collaborative and integrative approach for treating comorbid obesity and depression. It also demonstrates the utility of using the framework as a planning tool early in the evidence-generation pipeline.
Published: 2021
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11. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program

Author: Mike Reidy, Christine Lee, Michael Brändle, Sherita Hill Golden, Samuel Dagogo-Jack, David Kessler, Elizabeth Barrett-Connor, Steve Jones, Ling Chen, Judith Wylie-Rosett, Ping Zhang, Paula Williamson, Carlos Lorenzo, Leigh Perreault, Dana Dabelea, Santica Marcovina, Rachel Williams, Marie Smith, Carmen Pal, Patricia Katz, William H. Herman, Sharon L Edelstein, Yong Ma, Vanita R Aroda, Costas A Christophi, Catherine Kim, Sherita H Golden, Edward Horton, Kieren J Mather, George A. Bray, Kishore Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith, Julia A. St, Richard T. Tulley Amant, Paula C. Vicknair, Donald Williamson, Jeffery J. Zachwieja, Kenneth S. Polonsky, Janet Tobian, David A. Ehrmann, Margaret J. Matulik, Bart Clark, Kirsten Czech, Catherine DeSandre, Ruthanne Hilbrich, Wylie McNabb, Ann R. Semenske, Jose F. Caro, Kevin Furlong, Barry J. Goldstein, Pamela G. Watson, Kellie A. Smith, Jewel Mendoza, Wendi Wildman, Renee Liberoni, John Spandorfer, Constance Pepe, Richard P. Donahue, Ronald B. Goldberg, Ronald Prineas, Jeanette Calles, Juliet Ojito, Patricia Rowe, Paul Cassanova-Romero, Sumaya Castillo-Florez, Hermes J. Florez, Anna Giannella, Lascelles Kirby, Carmen Larreal, Olga Lara, Valerie McLymont, Jadell Mendez, Arlette Perry, Patrice Saab, Beth Veciana, Steven M. Haffner, Helen P. Hazuda, Maria G. Montez, Kathy Hattaway, Arlene Martinez, Tatiana Walker, Richard F. Hamman, Patricia V. Nash, Sheila C. Steinke, Lisa Testaverde, Denise R. Anderson, Larry B. Ballonoff, Alexis Bouffard, Brian Bucca, B. Ned Calonge, Lynne Delve, Martha Farago, James O. Hill, Shelley R. Hoyer, Tonya Jenkins, Bonnie T. Jortberg, Dione Lenz, Marsha Miller, David W. Price, Judith G. Regensteiner, Helen Seagle, Carissa M. Smith, Brent VanDorsten, Edward S. Horton, Kathleen E. Lawton, Catherine S. Poirier, Kati Swift, Ronald A. Arky, Marybeth Bryant, Jacqueline P. Burke, Enrique Caballero, Karen M. Callaphan, Barbara Fargnoli, Therese Franklin, Om P. Ganda, Ashley Guidi, Mathew Guido, Sharon D. Jackson, Alan M. Jacobsen, Lori Lambert, Sarah Ledbury, Margaret Kocal, Lyn M. Kula, Maureen A. Malloy, Maryanne Nicosia, Cathryn F. Oldmixon, Jocelyn Pan, Marizel Quitingon, Stacy Rubtchinsky, Jessica Sansoucy, Dana Schweizer, Ellen W. Seely, Donald Simonson, Fannie Smith, Caren G. Solomon, Jeanne Spellman, James Warram, Steven E. Kahn, Brenda K. Montgomery, Wilfred Fujimoto, Robert H. Knopp, Edward W. Lipkin, Michelle Marr, Ivy Morgan-Taggart, Anne Murillo, Dace Trence, Lonnese Taylor, April Thomas, Elaine C. Tsai, Abbas E. Kitabchi, Mary E. Murphy, Laura Taylor, Jennifer Dolgoff, William B. Applegate, Michael Bryer-Ash, Debra Clark, Sandra L. Frieson, Uzoma Ibebuogu, Raed Imseis, Helen Lambeth, Lynne C. Lichtermann, Hooman Oktaei, Harriet Ricks, Lily M.K. Rutledge, Amy R. Sherman, Clara M. Smith, Judith E. Soberman, Beverly Williams-Cleaves, Boyd E. Metzger, Mark E. Molitch, Mariana K. Johnson, Daphne T. Adelman, Catherine Behrends, Michelle Cook, Marian Fitzgibbon, Mimi M. Giles, Deloris Heard, Cheryl K.H. Johnson, Diane Larsen, Anne Lowe, Megan Lyman, David McPherson, Samsam C. Penn, Thomas Pitts, Renee Reinhart, Susan Roston, Pamela A. Schinleber, David M. Nathan, Charles McKitrick, Heather Turgeon, Mary Larkin, Kathy Abbott, Ellen Anderson, Laurie Bissett, Kristy Bondi, Enrico Cagliero, Jose C. Florez, Kali D’Anna, Linda Delahanty, Valerie Goldman, Peter Lou, Alexandra Poulos, Elyse Raymond, Christine Stevens, Beverly Tseng, Jerrold M. Olefsky, Mary Lou Carrion-Petersen, Madeline Beltran, Lauren N. Claravall, Jonalle M. Dowden, Steven V. Edelman, Robert R. Henry, Javiva Horne, Marycie Lamkin, Simona Szerdi Janesch, Diana Leos, Sunder Mudaliar, William Polonsky, Jean Smith, Jennifer Torio-Hurley, Karen Vejvoda, F. Xavier Pi-Sunyer, Jane E. Lee, David B. Allison, Nnenna Agharanya, Nancy J. Aronoff, Maria Baldo, Jill P. Crandall, Sandra T. Foo, Susan Hagamen, Jose A. Luchsinger, Kathy Parkes, Mary Beth Pena, Ellen S. Rooney, Gretchen E.H. Van Wye, Kristine A. Viscovich, David G. Marrero, Kieren J. Mather, Melvin J. Prince, Susie M. Kelly, Marcia A. Jackson, Gina McAtee, Paula Putenney, Ronald T. Ackermann, Carolyn M. Cantrell, Yolanda F. Dotson, Edwin S. Fineberg, Megan Fultz, John C. Guare, Angela Hadden, James M. Ignaut, Marion S. Kirkman, Erin O’Kelly Phillips, Beverly D. Porter, Paris J. Roach, Nancy D. Rowland, Madelyn L. Wheeler, Vanita Aroda, Robert E. Ratner, Gretchen Youssef, Sue Shapiro, Catherine Bavido-Arrage, Geraldine Boggs, Marjorie Bronsord, Ernestine Brown, Wayman W. Cheatham, Susan Cola, Cindy Evans, Peggy Gibbs, Tracy Kellum, Renee Wiggins, Milvia Lagarda, Lilia Leon, Claresa Levatan, Milajurine Lindsay, Asha K. Nair, Maureen Passaro, Angela Silverman, Gabriel Uwaifo, Debra Wells-Thayer, Mohammed F. Saad, Karol Watson, Maria Budget, Sujata Jinagouda, Medhat Botrous, Khan Akbar, Claudia Conzues, Perpetua Magpuri, Kathy Ngo, Amer Rassam, Debra Waters, Kathy Xapthalamous, Julio V. Santiago, Neil H. White, Angela L. Brown, Samia Das, Prajakta Khare-Ranade, Tamara Stich, Ana Santiago, Edwin Fisher, Emma Hurt, Tracy Jones, Michelle Kerr, Lucy Ryder, Cormarie Wernimont, Christopher D. Saudek, Vanessa Bradley, Emily Sullivan, Tracy Whittington, Caroline Abbas, Adrienne Allen, Frederick L. Brancati, Sharon Cappelli, Jeanne M. Clark, Jeanne B. Charleston, Janice Freel, Katherine Horak, Alicia Greene, Dawn Jiggetts, Deloris Johnson, Hope Joseph, Kimberly Loman, Henry Mosley, John Reusing, Richard R. Rubin, Alafia Samuels, Thomas Shields, Shawne Stephens, Kerry J. Stewart, LeeLana Thomas, Evonne Utsey, David S. Schade, Karwyn S. Adams, Janene L. Canady, Carolyn Johannes, Claire Hemphill, Penny Hyde, Leslie F. Atler, Patrick J. Boyle, Mark R. Burge, Lisa Chai, Kathleen Colleran, Ysela Gonzales, Doris A. Hernandez-McGinnis, Carolyn King, Sofya Rubinchik, Willette Senter, Jill Crandall, Harry Shamoon, Janet O. Brown, Gilda Trandafirescu, Elsie Adorno, Liane Cox, Helena Duffy, Samuel Engel, Allison Friedler, Angela Goldstein, Crystal J. Howard-Century, Jennifer Lukin, Stacey Kloiber, Nadege Longchamp, Helen Martinez, Dorothy Pompi, Jonathan Scheindlin, Elissa Violino, Elizabeth A. Walker, Elise Zimmerman, Joel Zonszein, Trevor Orchard, Rena R. Wing, Susan Jeffries, Gaye Koenning, M. Kaye Kramer, Susan Barr, Catherine Benchoff, Miriam Boraz, Lisa Clifford, Rebecca Culyba, Marlene Frazier, Ryan Gilligan, Stephanie Guimond, Susan Harrier, Louann Harris, Andrea Kriska, Bonny Rockette-Wagner, Qurashia Manjoo, Monica Mullen, Alicia Noel, Amy Otto, Jessica Pettigrew, Debra Rubinstein, Linda Semler, Cheryl F. Smith, Elizabeth Venditti, Valarie Weinzierl, Katherine V. Williams, Tara Wilson, Richard F. Arakaki, Renee W. Latimer, Narleen K. Baker-Ladao, Mae K. Isonaga, Ralph Beddow, Nina E. Bermudez, Lorna Dias, Jillian Inouye, Marjorie K. Mau, John S. Melish, Kathy Mikami, Pharis Mohideen, Sharon K. Odom, Raynette U. Perry, Robin E. Yamamoto, William C. Knowler, Norman Cooeyate, Mary A. Hoskin, Carol A. Percy, Alvera Enote, Camille Natewa, Kelly J. Acton, Vickie L. Andre, Rosalyn Barber, Shandiin Begay, Peter H. Bennett, Mary Beth Benson, Evelyn C. Bird, Brenda A. Broussard, Brian C. Bucca, Marcella Chavez, Sherron Cook, Jeff Curtis, Tara Dacawyma, Matthew S. Doughty, Roberta Duncan, Charlotte Dodge, Cyndy Edgerton, Jacqueline M. Ghahate, Justin Glass, Martia Glass, Dorothy Gohdes, Wendy Grant, Robert L. Hanson, Ellie Horse, Louise E. Ingraham, Merry Jackson, Priscilla Jay, Roylen S. Kaskalla, Kathleen M. Kobus, Jonathan Krakoff, Jason Kurland, Catherine Manus, Cherie McCabe, Sara Michaels, Tina Morgan, Yolanda Nashboo, Julie A. Nelson, Steven Poirier, Evette Polczynski, Christopher Piromalli, Jeanine Roumain, Debra Rowse, Robert J. Roy, Sandra Sangster, Janet Sewenemewa, Miranda Smart, Darryl Tonemah, Charlton Wilson, Michelle Yazzie, Raymond Bain, Sarah Fowler, Marinella Temprosa, Michael D. Larsen, Tina Brenneman, Sharon L. Edelstein, Solome Abebe, Julie Bamdad, Melanie Barkalow, Joel Bethepu, Tsedenia Bezabeh, Nicole Butler, Jackie Callaghan, Caitlin E. Carter, Costas Christophi, Gregory M. Dwyer, Mary Foulkes, Yuping Gao, Robert Gooding, Adrienne Gottlieb, Kristina L. Grimes, Nisha Grover-Fairchild, Lori Haffner, Heather Hoffman, Kathleen Jablonski, Tara L. Jones, Richard Katz, Preethy Kolinjivadi, John M. Lachin, Pamela Mucik, Robert Orlosky, Qing Pan, Susan Reamer, James Rochon, Alla Sapozhnikova, Hanna Sherif, Charlotte Stimpson, Ashley Hogan Tjaden, Fredricka Walker-Murray, Elizabeth M. Venditti, Andrea M. Kriska, Valerie Weinzierl, Jessica Harting, F. Alan Aldrich, John Albers, Greg Strylewicz, R. Eastman, Judith Fradkin, Sanford Garfield, Edward Gregg, Morton B. Brown, David Altshuler, Liana K. Billings, Maegan Harden, Toni I. Pollin, Alan R. Shuldiner, Paul W. Franks, and Marie-France Hivert
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction Sex hormone binding globulin (SHBG) levels are reported to be inversely associated with diabetes risk. It is unknown whether diabetes prevention interventions increase SHBG and whether resultant changes in SHBG affect diabetes risk. The purpose of this analysis was to determine whether intensive lifestyle intervention (ILS) or metformin changed circulating SHBG and if resultant changes influenced diabetes risk in the Diabetes Prevention Program (DPP).Research design and methods This is a secondary analysis from the DPP (1996–2001), a randomized trial of ILS or metformin versus placebo on diabetes risk over a mean follow-up of 3.2 years. The DPP was conducted across 27 academic study centers in the USA. Men, premenopausal and postmenopausal women without hormone use in the DPP were evaluated. The DPP included overweight/obese persons with elevated fasting glucose and impaired glucose tolerance. Main outcomes measures were changes in SHBG levels at 1 year and risk of diabetes over 3 years.Results ILS resulted in significantly higher increases (postmenopausal women: p
Published: 2020
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12. Lifestyle change program engagement in real-world clinical practice: a mixed-methods analysis

Author: Hsiao-Ching Huang, Nina K Szwerinski, Catherine Nasrallah, Qiwen Huang, Vidita Chopra, Elizabeth M Venditti, Kristen M J Azar, and Robert J Romanelli
Subjects: Behavioral Neuroscience, Applied Psychology
Abstract: Participant engagement in structured lifestyle change programs (LCPs) is essential for adopting behaviors that promote weight loss; however, the challenges to, and facilitators that promote, engagement with such programs are not well understood. We conducted a mixed-methods study among real-world LCP participants to assess factors associated with program engagement and to examine the reasons for withdrawal. Using electronic health records (EHR), we identified LCP eligible participants between 2010 and 2017. Multivariable logistic regression was used to assess associations between program engagement and baseline characteristics. Semi-structured interviews with LCP participants were conducted and thematically analyzed to examine reasons for withdrawal. A total of 1,813 LCP participants were included. The median number of sessions attended was 10 of 21–25 sessions. Highest LCP engagement was associated with factors potentially related to self-efficacy/motivation, such as older age, higher baseline weight, prior healthcare utilization and an absence of a history of smoking or depression. Engagement was also negatively associated with being Non-Hispanic Black versus White. The qualitative analysis of the interviews revealed four general themes pertaining to participants’ withdrawal: competing priorities, perceived program effectiveness, characteristics of the program, and facilitator-related factors. Taken together, results from this mixed-methods study suggest that motivation and self-efficacy are important for program engagement; future LCP enhancements should incorporate flexible formats that may help participants manage competing priorities and maximize personal and cultural relevance for all racial/ethnic groups, especially those who have not benefitted fully. Furthermore, participants should be encouraged to set realistic goals to manage expectations.
Published: 2023
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13. Profiles of sociodemographic, behavioral, clinical and psychosocial characteristics among primary care patients with comorbid obesity and depression

Author: Jun Ma, Lan Xiao, Nan Lv, Lisa G. Rosas, Megan A. Lewis, Jeremy D. Goldhaber-Fiebert, Elizabeth M. Venditti, Mark B. Snowden, Lenard Lesser, and Elizabeth Ward
Subjects: Medicine
Abstract: The objective of this study is to characterize profiles of obese depressed participants using baseline data collected from October 2014 through December 2016 for an ongoing randomized controlled trial (n=409) in Bay Area, California, USA. Four comorbidity severity categories were defined by interaction of the binary levels of body mass index (BMI) and depression Symptom Checklist 20 (SCL20) scores. Sociodemographic, behavioral, clinical and psychosocial characteristics were measured. Mean (SD) age was 51 (12.1) years, BMI 36.7 (6.4) kg/m2, and SCL20 1.5 (0.5). Participants in the 4 comorbidity severity categories had similar sociodemographic characteristics, but differed significantly in the other characteristics. Two statistically significant canonical dimensions were identified. Participants with BMI≥35 and SCL20≥1.5 differed significantly from those with BMI
Published: 2017
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14. HOMBRE: A Trial Comparing 2 Weight Loss Approaches for Latino Men

Author: Lisa G. Rosas, Nan Lv, Lan Xiao, Elizabeth M. Venditti, Megan A. Lewis, Kristen M.J. Azar, Steven P. Hooker, Patricia Zavella, and Jun Ma
Subjects: Behavior Therapy, Epidemiology, Weight Loss, Public Health, Environmental and Occupational Health, Humans, Hispanic or Latino, Obesity, Middle Aged, Overweight
Abstract: Latino men have been drastically under-represented in research to identify effective behavioral weight-loss interventions. This trial compared 2 interventions for weight loss: (1) a culturally adapted intervention (HOMBRE) and (2) a minimal-intensity intervention.Randomized controlled trial.Latino men with a BMI ≥27 kg/mHOMBRE provided men a choice among 3 options: coach-facilitated group sessions using online video conferencing, coach-facilitated group sessions in person, and prerecorded videos of group sessions available online.The primary outcome was the proportion of participants sustaining clinically significant (≥5% of baseline) weight loss at 18 months. Secondary outcomes included weight loss trajectory over time, 3% and 10% weight loss, cardiometabolic risk factors, health behaviors, and psychosocial well-being at baseline and 18 months. Data were analyzed from October 6, 2020 to January 15, 2022.Participants were predominantly middle aged (47.0 [SD=11.9] years), were married (74.3%), were with at least some college experience (79.7%), and had middle to upper incomes (72.4% with annual family incomes$75,000). Their average BMI was 33.1 kg/mAmong Latino men with overweight and obesity, HOMBRE was not more effective for clinically significant weight loss than a minimal-intensity intervention at 18 months.
Published: 2022
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15. Correction: Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial.

Author: Nan Lv, Lan Xiao, Marzieh Majd, Philip W Lavori, Joshua M Smyth, Lisa G Rosas, Elizabeth M Venditti, Mark B Snowden, Megan A Lewis, Elizabeth Ward, Lenard I Lesser, Leanne M Williams, Kristen M J Azar, and Jun Ma
Subjects: Medicine, Science
Abstract: [This corrects the article DOI: 10.1371/journal.pone.0231743.].
Published: 2020
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16. Variability in engagement and progress in efficacious integrated collaborative care for primary care patients with obesity and depression: Within-treatment analysis in the RAINBOW trial.

Author: Nan Lv, Lan Xiao, Marzieh Majd, Philip W Lavori, Joshua M Smyth, Lisa G Rosas, Elizabeth M Venditti, Mark B Snowden, Megan A Lewis, Elizabeth Ward, Lenard Lesser, Leanne M Williams, Kristen M J Azar, and Jun Ma
Subjects: Medicine, Science
Abstract: IntroductionThe RAINBOW randomized clinical trial validated the efficacy of an integrated collaborative care intervention for obesity and depression in primary care, although the effect was modest. To inform intervention optimization, this study investigated within-treatment variability in participant engagement and progress.MethodsData were collected in 2014-2017 and analyzed post hoc in 2018. Cluster analysis evaluated patterns of change in weekly self-monitored weight from week 6 up to week 52 and depression scores on the Patient Health Questionnaire-9 (PHQ-9) from up to 15 individual sessions during the 12-month intervention. Chi-square tests and ANOVA compared weight loss and depression outcomes objectively measured by blinded assessors to validate differences among categories of treatment engagement and progress defined based on cluster analysis results.ResultsAmong 204 intervention participants (50.9 [SD, 12.2] years, 71% female, 72% non-Hispanic White, BMI 36.7 [6.9], PHQ-9 14.1 [3.2]), 31% (n = 63) had poor engagement, on average completing self-monitored weight in ConclusionsParticipants demonstrating poor engagement or poor progress could be identified early during the intervention and were more likely to fail treatment at the end of the intervention. This insight could inform individualized and timely optimization to enhance treatment efficacy.Trial registrationClinicalTrials.gov# NCT02246413.
Published: 2020
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17. Clinical course of Coronavirus Disease-19 in patients with haematological malignancies is characterized by a longer time to respiratory deterioration compared to non-haematological ones: results from a case–control study

Author: A. Oliva, A. Curtolo, L. Volpicelli, F. Cancelli, C. Borrazzo, F. Cogliati Dezza, G. Marcelli, F. Gavaruzzi, S. Di Bari, P. Ricci, O. Turriziani, C. M. Mastroianni, and M. Venditti
Subjects: Microbiology (medical), SARS-CoV-2, non-Hodgkin lymphoma, case-control studies, COVID-19, thrombocytopenia, adrenal cortex hormones, albumins, General Medicine, multiple myeloma, retrospective studies, anti-bacterial agents, Infectious Diseases, SARS-CoV2, haematological malignancy, humans, hematologic neoplasms, neutropenia
Abstract: Background We evaluated clinical features and risk factors for mortality in patients with haematological malignancies and COVID-19. Methods Retrospective, case–control (1:3) study in hospitalized patients with COVID-19. Cases were patients with haematological malignancies and COVID-19, controls had COVID-19 without haematological malignancies. Patients were matched for sex, age and time of hospitalization. Results Overall, 66 cases and 198 controls were included in the study. Cases had higher prior corticosteroid use, infection rates, thrombocytopenia and neutropenia and more likely received corticosteroids and antibiotics than controls. Cases had higher respiratory deterioration than controls (78.7% vs 65.5%, p = 0.04). Notably, 29% of cases developed respiratory worsening > 10 days after hospital admission, compared to only 5% in controls. Intensive Care Unit admission and mortality were higher in cases than in controls (27% vs 8%, p = 0.002, and 35% vs 10%, p At multivariable analysis, having haematological malignancy [OR4.76, p p = 0.004], prior infections [OR57.7, p = 0.006], thrombocytopenia [OR3.03, p p = 0.001], low albumin levels [OR3.1, p = 0.001] and ≥ 10 days from hospital admission to respiratory worsening [OR3.3, p = 0.002] were independently associated with mortality. In cases, neutropenia [OR3.1, p p p p = 0.044], the variation of the CT lung score during hospitalization [OR2.6, p = 0.006] and active treatment [OR 4.4, p Conclusion An underlying haematological malignancy was associated with a worse clinical outcome in COVID-19 patients. A prolonged clinical monitoring is needed, since respiratory worsening may occur later during hospitalization.
Published: 2022
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18. Cross-trial prediction of depression remission using problem-solving therapy: A machine learning approach

Author: Thomas, Kannampallil, Ruixuan, Dai, Nan, Lv, Lan, Xiao, Chenyang, Lu, Olusola A, Ajilore, Mark B, Snowden, Elizabeth M, Venditti, Leanne M, Williams, Emily A, Kringle, and Jun, Ma
Subjects: Machine Learning, Psychotherapy, Psychiatry and Mental health, Clinical Psychology, Treatment Outcome, Depression, Humans, Female, Prospective Studies, Algorithms
Abstract: Psychotherapy is a standard depression treatment; however, determining a patient's prognosis with therapy relies on clinical judgment that is subject to trial-and-error and provider variability.To develop machine learning (ML) algorithms to predict depression remission for patients undergoing 6 months of problem-solving therapy (PST).Using data from the treatment arm of 2 randomized trials, ML models were trained and validated on ENGAGE-2 (ClinicalTrials.gov, #NCT03841682) and tested on RAINBOW (ClinicalTrials.gov, #NCT02246413) for predictions at baseline and at 2-months. Primary outcome was depression remission using the Depression Symptom Checklist (SCL-20) score 0.5 at 6 months. Predictor variables included baseline characteristics (sociodemographic, behavioral, clinical, psychosocial) and intervention engagement through 2-months.Of the 26 candidate variables, 8 for baseline and 11 for 2-months were predictive of depression remission, and used to train the models. The best-performing model predicted remission with an accuracy significantly greater than chance in internal validation using the ENGAGE-2 cohort, at baseline [72.6% (SD = 3.6%), p 0.0001] and at 2-months [72.3% (5.1%), p 0.0001], and in external validation with the RAINBOW cohort at baseline [58.3% (0%), p 0.0001] and at 2-months [62.3% (0%), p 0.0001]. Model-agnostic explanations highlighted key predictors of depression remission at the cohort and patient levels, including female sex, lower self-reported sleep disturbance, lower sleep-related impairment, and lower negative problem orientation.ML models using clinical and patient-reported data can predict depression remission for patients undergoing PST, affording opportunities for prospective identification of likely responders, and for developing personalized early treatment optimization along the patient care trajectory.
Published: 2022
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19. Association of COVID-19 impact with outcomes of an integrated obesity and depression intervention: Posthoc analysis of an RCT

Author: Emily A, Kringle, Nan, Lv, Corina R, Ronneberg, Nancy, Wittels, Lisa G, Rosas, Lesley E, Steinman, Joshua M, Smyth, Ben S, Gerber, Lan, Xiao, Elizabeth M, Venditti, Olusola A, Ajilore, Leanne M, Williams, and Jun, Ma
Subjects: Adult, Nutrition and Dietetics, Depression, Endocrinology, Diabetes and Metabolism, Quality of Life, COVID-19, Humans, Obesity, Anxiety
Abstract: To examine the association between COVID-19 impact and clinical outcomes of an integrated collaborative care intervention for adults with obesity and comorbid depression.Latent class analysis identified clusters of self-reported COVID-19 impact. Cluster characteristics were examined using Fishers' least significant difference method and canonical discriminant analysis. Intervention vs. usual care effects on primary (body mass index [BMI], depressive symptoms) and secondary (anxiety symptoms and other psychosocial) outcomes stratified by cluster were examined using linear mixed models.Three clusters were identified: mental health and sleep impact (cluster 1, n = 37), economic impact (cluster 2, n = 18), and less overall impact (cluster 3, n = 20). Clusters differed in age, income, diet, and baseline coping skills. The intervention led to improvements across several health outcomes compared with usual care, with medium to large effects on functional impairments (standardized mean difference, -0.7 [95% CI: -1.3, -0.1]) in cluster 1, depressive symptoms (-1.1 [95% CI: -2.0, -0.1]) and obesity-related problems (-1.6 [95% CI: -2.8, -0.4]) in cluster 2, and anxiety (-1.1 [95% CI: -1.9, -0.3]) in cluster 3.People with obesity and comorbid depression may have varied intervention responses based on COVID-19 impact. Interventions tailored to specific COVID-19 impact clusters may restore post-pandemic health.
Published: 2022
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20. Profiles of Accelerometry-Derived Physical Activity Are Related to Perceived Physical Fatigability in Older Adults.

Author: Jessica L. Graves, Yujia (Susanna) Qiao, Kyle D. Moored, Robert M. Boudreau, Elizabeth M. Venditti, Robert T. Krafty, Eric J. Shiroma, Jaroslaw Harezlak, and Nancy W. Glynn
Published: 2021
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21. Translating the Diabetes Prevention Program Lifestyle Intervention to the Military Setting

Author: M Kaye Kramer, Susan C Agee, Rachel G Miller, Vincent C Arena, Karl K Vanderwood, Yvonne L Eaglehouse, Elizabeth M Venditti, and Andrea M Kriska
Subjects: Public Health, Environmental and Occupational Health, General Medicine, Feature Article and Original Research
Abstract: Introduction Diabetes and obesity pose a significant burden for the U.S. military beneficiary population, creating a great need to provide evidence-based diabetes and obesity prevention services for military personnel, retirees, and their dependents. Despite increasing dissemination of the Diabetes Prevention Program (DPP) lifestyle intervention nationwide, formal evaluation of implementation of this highly successful program is limited in the military setting. The purpose of this study is to prospectively evaluate delivery of a direct adaptation of a 1-year DPP lifestyle intervention at a U.S. Air Force medical facility, Wright-Patterson Medical Center (WPMC), to determine the feasibility of delivery of the program in a group of at-risk active duty military, retirees, and family members, as well as assess effectiveness in improving weight and other risk factors for type 2 diabetes. Materials and Methods A pre/post study design was utilized to evaluate feasibility and effectiveness of the DPP Group Lifestyle Balance (GLB), an up-to-date, 22-session direct adaptation of the DPP curriculum, at WPMC. Participants chose to complete the 1-year program either in coach-led face-to-face groups or via DVD with weekly telephonic coach contact. The study was approved by the University of Pittsburgh and WPMC Institutional Review Boards. Results A total of 99 individuals enrolled in the study, with 83 (84%) and 77 (78%) completing 6- and 12-month follow-up assessments, respectively. The mean age of participants at baseline was 57 (range 20-85 years), with 63% being female. The group was comprised of individuals who were non-Hispanic White (73.7%), non-Hispanic Black (18.2%), and other race or Hispanic ethnicity (8.1%). Within this group, there were 10 active duty military, 37 retirees, and 52 family members. The DPP-GLB program was shown to be feasible to implement in this military healthcare setting as demonstrated by the high engagement over the course of the year-long program. Significant improvements were shown in the two main behavioral goals: mean weight (−12.8 lbs, −6.3%, P Conclusions These results demonstrate that the DPP-GLB program delivered via face-to-face groups or DVD was feasible and effective in improving weight, PA levels, and diabetes and cardiovascular risk factors in this group of active and retired military personnel and their family members. The program was well received by the program participants as well as the WPMC team. These findings offer a model for provision of the DPP-GLB program throughout the Military Health System.
Published: 2022
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22. Diet Improvements in Community-Dwelling Older Adults in the Mobility and Vitality Lifestyle Program

Author: Jessica Cheng, Lora E. Burke, Elizabeth M. Venditti, Susan M. Sereika, Nancy W. Glynn, Steven M. Albert, and Anne B. Newman
Subjects: Weight Loss, Humans, Independent Living, Overweight, Geriatrics and Gerontology, Life Style, Gerontology, Article, Aged, Diet
Abstract: This analysis examined whether a community-based intervention produced measurable improvements in dietary habits. MOVE UP combined translational, evidence-based weight management and healthy aging interventions using a non-randomized design. This 13-month intervention included 32 group sessions, explicit calorie and physical activity goals, self-monitoring, and nutrition education. Participants were ( N = 297) older adults (mean = 68.0 years) with overweight and obesity. Diet was measured using Rate Your Plate (RYP)-Heart. Changes in scores from baseline to 5, 9, and 13 months were assessed using mixed models. MOVE UP successfully shifted eating patterns from baseline (mean = 50.9) to 5 months (mean = 55.1) ( p < .0001) adjusted for age, sex, and race. Improvements persisted through 9 (mean = 54.7) and 13 months (mean = 55.0) ( p < .0001). Although participants were not prescribed a specific diet, RYP-Heart indicated positive dietary shifts. Community-implemented behavioral weight loss interventions may assess the modifiability of dietary habits with a simple, easy-to-administer tool.
Published: 2022
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23. Characterising trafficking and trade of pangolins in the Gulf of Guinea

Author: Daniel J. Ingram, Drew T. Cronin, Daniel W.S. Challender, Dana M. Venditti, and Mary K. Gonder
Subjects: Ecology, QH540-549.5
Abstract: Humans and pangolins have a long and intertwined history in Africa and Asia, with the species having been used for subsistence, livelihood, medicinal, and cultural purposes. Populations of Asian pangolins have severely declined, and intercontinental trafficking of African pangolin scales to Asia has emerged in the last decade. Coastal countries in the Gulf of Guinea have been highlighted as hotspots of illegal pangolin trade, and in 2017, international commercial trade in pangolins was banned. We characterise the trade and international trafficking of African pangolins in the coastal countries around the Gulf of Guinea using data across three tiers. First, we investigated which countries were most heavily involved in international trafficking using seizure data. Second, we investigated where domestic seizures of pangolins took place, and whether they were seized with other species. Finally, we tracked the open sale of pangolins across 20-years at the main wild meat market in Malabo, Equatorial Guinea, to investigate patterns of pangolin sales in a capital city. We found a total of 55893 kg of pangolin scales in 33 seizures between 2012 and 2018, with Cameroon and Nigeria being the most common export countries for international trafficking of pangolin scales. Cameroon had the largest number of domestic seizures (45); we also observed a shift from seizures of meat to scales from 2013 onwards. At the Malabo market a total of 11207 Phataginus pangolins and 366 Smutsia pangolins were sold between 1997 and 2017, and the number and price of pangolins increased over time for both genera and corresponded to a shift in the import of pangolins from Cameroon. Together, these results highlight the scale of trade and trafficking in pangolins within and from this region. Keywords: Africa, Bushmeat, Conservation, Phataginus, Smutsia, Wild meat
Published: 2019
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24. Problem-solving therapy–induced amygdala engagement mediates lifestyle behavior change in obesity with comorbid depression: a randomized proof-of-mechanism trial

Author: Nan Lv, Philip W. Lavori, Trisha Suppes, Joshua M. Smyth, Elizabeth M. Venditti, Wesley K. Lefferts, Lan Xiao, Janine M. Simmons, Megan A. Lewis, Leanne M. Williams, Mark B Snowden, Lisa G. Rosas, Jun Ma, Andrea N. Goldstein-Piekarski, Joseph Wielgosz, Patrick Stetz, and Olusola Ajilore
Subjects: Adult, medicine.medical_specialty, Medicine (miscellaneous), Amygdala, Physical medicine and rehabilitation, Neuroimaging, Weight loss, Functional neuroimaging, Intervention (counseling), medicine, Humans, Obesity, Life Style, Depression (differential diagnoses), Nutrition and Dietetics, Depression, business.industry, Mechanism (biology), medicine.disease, Psychotherapy, Original Research Communications, medicine.anatomical_structure, medicine.symptom, business
Abstract: BACKGROUND: Depression hinders obesity treatment; elucidating mechanisms may enable treatment enhancements. OBJECTIVES: The aim was to investigate whether changes in neural targets in the negative affect circuit following psychotherapy mediate subsequent changes in weight and behaviors. METHODS: Adults (n = 108) with obesity and depression were randomly assigned to usual care or an intervention that delivered problem-solving therapy (PST) for depression over 2 mo. fMRI for brain imaging was performed at baseline and 2 mo. BMI, physical activity, and diet were measured at baseline and 12 mo. Mediation analysis assessed between-group differences in neural target changes using t test and correlations between neural target changes and outcome changes (simple and interaction effect) using ordinary least-squares regression. RESULTS: Compared with usual care, PST led to reductions in left amygdala activation (−0.75; 95% CI: −1.49, −0.01) and global scores of the negative affect circuit (−0.43; −0.81, −0.06), engaged by threat stimuli. Increases in amygdala activation and global circuit scores at 2 mo correlated with decreases in physical activity outcomes at 12 mo in the usual-care group; these relations were altered by PST. In relation to change in leisure-time physical activity, standardized β-coefficients were −0.67 in usual care and −0.01 in the intervention (between-group difference: 0.66; 0.02, 1.30) for change in left amygdala activation and −2.02 in usual care and −0.11 in the intervention (difference: 1.92; 0.64, 3.20) for change in global circuit scores. In relation to change in total energy expenditure, standardized β-coefficients were −0.65 in usual care and 0.08 in the intervention (difference: 0.73; 0.29, 1.16) for change in left amygdala activation and −1.65 in usual care and 0.08 in the intervention (difference: 1.74; 0.85, 2.63) for change in global circuit scores. Results were null for BMI and diet. CONCLUSIONS: Short-term changes in the negative affect circuit engaged by threat stimuli following PST for depression mediated longer-term changes in physical activity. This trial was registered at www.clinicaltrials.gov as NCT02246413 (https://clinicaltrials.gov/ct2/show/NCT02246413).
Published: 2021
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25. Weight Loss through Lifestyle Intervention Improves Mobility in Older Adults

Author: Anne B. Newman, Steven M. Albert, Judith R. Rager, Lora E. Burke, Janice C. Zgibor, Linda Semler, Joni Vander Bilt, Lori A Kieffer, Robert M. Boudreau, Elizabeth M. Venditti, John M. Jakicic, Nancy W. Glynn, Kenneth J. Smith, and Michelle E. Danielson
Subjects: Male, Research design, medicine.medical_specialty, Overweight, Weight loss, Weight Loss, Weight management, Lifestyle intervention, Humans, Medicine, Community health workers, Obesity, Intervention Research, Mobility Limitation, Life Style, Aged, business.industry, Public health, General Medicine, medicine.disease, Physical therapy, Female, Independent Living, Geriatrics and Gerontology, medicine.symptom, business, Gerontology
Abstract: Background and Objectives The high prevalence of overweight or obesity in older adults is a public health concern because obesity affects health, including the risk of mobility disability. Research Design and Methods The Mobility and Vitality Lifestyle Program, delivered by community health workers (CHWs), enrolled 303 community-dwelling adults to assess the impact of a 32-session behavioral weight management intervention. Participants completed the program at 26 sites led by 22 CHWs. Participation was limited to people aged 60–75 who had a body mass index (BMI) of 27–45 kg/m2. The primary outcome was the performance on the Short Physical Performance Battery (SPPB) over 12 months. Results Participants were aged 67.7 (SD 4.1) and mostly female (87%); 22.7% were racial minorities. The mean (SD) BMI at baseline was 34.7 (4.7). Participants attended a median of 24 of 32 sessions; 240 (80.3%) completed the 9- or 13-month outcome assessment. Median weight loss in the sample was 5% of baseline body weight. SPPB total scores improved by +0.31 units (p < .006), gait speed by +0.04 m/s (p < .0001), and time to complete chair stands by −0.95 s (p < .0001). Weight loss of at least 5% was associated with a gain of +0.73 in SPPB scores. Increases in activity (by self-report or device) were not independently associated with SPPB outcomes but did reduce the effect of weight loss. Discussion and Implications Promoting weight management in a community group setting may be an effective strategy for reducing the risk of disability in older adults.
Published: 2021
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26. Effect of ceftazidime/avibactam plus fosfomycin combination on 30 day mortality in patients with bloodstream infections caused by KPC-producing

Author: A, Oliva, L, Volpicelli, S, Di Bari, A, Curtolo, C, Borrazzo, F, Cogliati Dezza, A, Cona, S, Agrenzano, A, Mularoni, M, Trancassini, F, Mengoni, S, Stefani, G, Raponi, and M, Venditti
Abstract: The primary outcome of the study was to evaluate the effect on 30 day mortality of the combination ceftazidime/avibactam + fosfomycin in the treatment of bloodstream infections (BSIs) caused by KPC-producingFrom October 2018 to March 2021, a retrospective, two-centre study was performed on patients with KPC-Overall, 221 patients were included in the study. Following the 1:1 match, 122 subjects were retrieved: 61 cases (ceftazidime/avibactam + fosfomycin) and 61 controls (ceftazidime/avibactam ± other). No difference in overall mortality emerged between cases and controls, whereas controls had more non-BSI KPC-Our data show that fosfomycin was used in the treatment of KPC
Published: 2022

27. Association of Intensive Lifestyle and Metformin Interventions With Frailty in the Diabetes Prevention Program Outcomes Study

Author: Jill P. Crandall, Andrea M. Kriska, Sherita Hill Golden, Hermes Florez, Helen P. Hazuda, José A. Luchsinger, Qing Pan, Elizabeth M. Venditti, and George A. Bray
Subjects: Male, Aging, medicine.medical_specialty, THE JOURNAL OF GERONTOLOGY: Medical Sciences, 030209 endocrinology & metabolism, Placebo, Gee, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Humans, Hypoglycemic Agents, Medicine, 030212 general & internal medicine, Prediabetes, Life Style, Frailty, business.industry, Repeated measures design, Odds ratio, Middle Aged, medicine.disease, Metformin, Clinical trial, Diabetes Mellitus, Type 2, Female, Geriatrics and Gerontology, business, Follow-Up Studies, medicine.drug
Abstract: Background Frailty is a geriatric syndrome of decreased physiologic reserve and resistance to stressors that results in increased vulnerability to adverse health outcomes with aging. Diabetes and hyperglycemia are established risk factors for frailty. We sought to examine whether the odds of frailty among individuals at high risk of diabetes randomized to treatment with intensive lifestyle (ILS), metformin, or placebo differed after long-term follow-up. Method The sample comprised participants in the Diabetes Prevention Program (DPP) clinical trial, who continued follow-up in the DPP Outcomes Study (DPPOS) and completed frailty assessments in DPPOS Years 8 (n = 2385) and 10 (n = 2289), approximately 12 and 14 years after DPP randomization. Frailty was classified using Fried Frailty Phenotype criteria. GEE models adjusting for visit year with repeated measures pooled for Years 8 and 10 were used to estimate pairwise odds ratios (ORs) between ILS, metformin, and placebo for the outcomes of frail and prefrail versus nonfrail. Results Frailty prevalence by treatment group was ILS = 3.0%, metformin = 5.4%, placebo = 5.7% at Year 8, and ILS = 3.6%, metformin = 5.3%, placebo = 5.4% at Year 10. Odds ratios (95% CI) estimated with GEE models were ILS versus placebo, 0.62 (0.42–0.93), p = .022; metformin versus placebo, 0.99 (0.69–1.42), p = .976; and ILS versus metformin, 0.63 (0.42–0.94), p = .022. Odds of being frail versus nonfrail were 37% lower for ILS compared to metformin and placebo. Conclusions Early ILS intervention, at an average age of about 50 years, in persons at high risk of diabetes may reduce frailty prevalence in later life. Metformin may be ineffective in reducing frailty prevalence. Clinical Trials Registration Numbers NCT00004992 (DPP) and NCT00038727 (DPPOS).
Published: 2021
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28. Diet quality, weight loss, and diabetes incidence in the Diabetes Prevention Program (DPP)

Author: Judith Wylie-Rosett, Lindsay M. Jaacks, Dana Dabelea, Ashley H. Tjaden, Elizabeth M. Venditti, Sharon L. Edelstein, Linda M. Delahanty, Benjamin T. Allaire, Mary A. Hoskin, Karla A. Temple, and John W. Apolzan
Subjects: Lifestyle intervention, medicine.medical_specialty, Diabetes risk, Race, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Dietary pattern, 030209 endocrinology & metabolism, lcsh:TX341-641, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Internal medicine, Diabetes mellitus, medicine, 030212 general & internal medicine, Prediabetes, Obesity, Diabetes prevention, lcsh:R5-920, Nutrition and Dietetics, lcsh:TP368-456, business.industry, AHEI, Weight change, Public Health, Environmental and Occupational Health, Body weight, medicine.disease, Metformin, lcsh:Food processing and manufacture, medicine.symptom, business, lcsh:Medicine (General), lcsh:Nutrition. Foods and food supply, medicine.drug, Research Article, DPP
Abstract: Background We evaluated whether diet quality is a predictor of weight loss and reduced diabetes risk, independent of caloric intake in the Diabetes Prevention Program (DPP) cohort, a randomized clinical trial of adults at risk for diabetes. Methods This secondary analysis included 2914 participants with available data (964 intensive lifestyle (ILS), 977 metformin, 973 placebo). Dietary intake was assessed using a 117-item food frequency questionnaire. Diet quality was quantified using the Alternative Healthy Eating Index 2010 (AHEI). AHEI ranges from 0 to 110, with higher scores corresponding to higher quality diets. ILS participants had greater improvement (p Results An increase in AHEI score was associated with weight loss in ILS [β per 10-point increase (SE) -1.2 kg (0.3, p p p = 0.01)]. However, AHEI change was not associated with incident diabetes in any group before or after adjustment for weight change. Conclusions Controlling for weight, diet quality was not associated with diabetes incidence but helps achieve weight loss, an important factor in diabetes prevention.
Published: 2020
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29. The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures

Author: Andrea M, Kriska, Bonny, Rockette-Wagner, Sharon L, Edelstein, George A, Bray, Linda M, Delahanty, Mary A, Hoskin, Edward S, Horton, Elizabeth M, Venditti, William C, Knowler, and Marie-France, Hivert
Subjects: Research design, medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Hypoglycemic Agents, Medicine, 030212 general & internal medicine, Exercise, Life Style, Advanced and Specialized Nursing, business.industry, Proportional hazards model, Hazard ratio, Clinical Care/Education/Nutrition/Psychosocial Research, medicine.disease, Metformin, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Cohort, business
Abstract: OBJECTIVE Across the Diabetes Prevention Program (DPP) follow-up, cumulative diabetes incidence remained lower in the lifestyle compared with the placebo and metformin randomized groups and could not be explained by weight. Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention. RESEARCH DESIGN AND METHODS Yearly self-reported PA and diabetes assessment and oral glucose tolerance test results (fasting glucose semiannually) were collected for 3,232 participants with one accelerometry assessment 11–13 years after randomization (n = 1,793). Mixed models determined PA differences across treatment groups. The association between PA and diabetes incidence was examined using Cox proportional hazards models. RESULTS There was a 6% decrease (Cox proportional hazard ratio 0.94 [95% CI 0.92, 0.96]; P < 0.001) in diabetes incidence per 6 MET-h/week increase in time-dependent PA for the entire cohort over an average of 12 years (controlled for age, sex, baseline PA, and weight). The effect of PA was greater (12% decrease) among participants less active at baseline ( CONCLUSIONS PA was inversely related to incident diabetes in the entire cohort across the study, with cross-sectional accelerometry results supporting these findings. This highlights the importance of PA within lifestyle intervention efforts designed to prevent diabetes and urges health care providers to consider both PA and weight when counseling high-risk patients.
Published: 2020
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30. Group Lifestyle Phone Maintenance for Weight, Health, and Physical Function in Adults Aged 65–80 Years: A Randomized Clinical Trial

Author: Vincent C. Arena, Marsha D. Marcus, Rachel G. Miller, Bonny Rockette-Wagner, Elizabeth M. Venditti, and Susan L. Greenspan
Subjects: Male, Aging, medicine.medical_specialty, THE JOURNAL OF GERONTOLOGY: Medical Sciences, Overweight, Body Mass Index, law.invention, Randomized controlled trial, Weight loss, law, Outcome Assessment, Health Care, Weight Loss, Weight management, Humans, Medicine, Healthy Lifestyle, Obesity, Exercise, Life Style, Aged, Aged, 80 and over, business.industry, Weight change, medicine.disease, Telemedicine, Telephone, Weight Reduction Programs, Blood pressure, Psychotherapy, Group, Physical therapy, Patient Compliance, Female, Periodicals as Topic, Geriatrics and Gerontology, medicine.symptom, business, Body mass index
Abstract: Background Group lifestyle sessions with phone maintenance could improve weight, health, and function in vulnerable older adults. Methods Community-dwelling adults (N = 322) with body mass index (BMI, kg/m2) ≥27 and additional risk factors received 12 one-hour in-person behavioral weight management group sessions then were randomized to 8 half-hour telephone sessions (n = 162) or newsletter control (n = 160) from 4 to 12 months with no treatment contact thereafter. Primary outcome was 0- to 12-month weight change. Cardiometabolic, short physical performance battery (SPPB), and self-reported activity changes were assessed at 12 and 24 months. Results At baseline, the mean (SD) age was 71.2 (4.3) and BMI was 33.8 (5.1). Participants were 77% women, 13% Black, 85% retired, averaging 4 medical conditions, and taking blood pressure (67.4%) and lipid-lowering (51.6%) medications. At 12 months, a greater proportion of the phone group (66.0%) achieved ≥5% weight loss compared with newsletter control (53.2%; p = .02). Mean (95% CI) weight loss was greater for phone (−6.6 kg [−7.5, −5.8]) than newsletter (−5.1 kg [−7.2, −3.0]); p = .01. Modest lipid, glucose, and blood pressure improvements were found, but did not differ significantly between groups. Small SPPB and activity improvements were maintained at 12 and 24 months in both groups. Conclusions Brief phone contacts compared to newsletters enhanced weight loss maintenance among older high-risk adults at 1 year, but not cardiometabolic outcomes. Modest functional improvements were observed in both. Lower-intensity maintenance contacts (phone or newsletter) for weight, health, and physical function in older adults warrant further study. Clinical Trials Registration Number NCT03192475
Published: 2020
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31. Sleep characteristics modify the associations of physical activity during pregnancy and gestational weight gain

Author: Marquis S. Hawkins, Rachel K. Conlon, Shannon Donofry, Daniel J. Buysse, Elizabeth M. Venditti, Yu Cheng, and Michele D. Levine
Subjects: Obstetrics and Gynecology, General Medicine
Abstract: Objective: Excessive gestational weight gain (eGWG) is associated with adverse long-term maternal outcomes. Most lifestyle interventions that incorporate physical activity have been ineffective at reducing eGWG. The purpose of this study is to determine if sleep modified the relationships between physical activity change from the 2nd to 3rd trimester and the odds of excessive gestational weight gain (eGWG). Methods: This was a secondary data analysis of a prospective cohort study of pregnant birthing people with overweight or obesity (n = 105). We estimated physical activity energy expenditure (PAEE) in the 2nd and 3rd trimesters of pregnancy and sleep characteristics (i.e., sleep quality, daytime dysfunction, sleep efficiency, sleep duration) in the 2nd trimester of pregnancy with validated measures. We used regression models with sleep and PAEE change (increase/stable vs. decrease) interaction terms to examine the impact of sleep on PAEE change and eGWG. Results: Mean GWG was 37.02±16.76 lbs. and 80% of participants experienced eGWG. 18% of participants increased their PAEE from the 2nd to the 3rd trimester. Increasing (vs. decreasing) PAEE was associated with lower log-odds of eGWG only among participants that slept at least 8 hours/night (p=0.06), had at least 85% sleep efficiency (p=0.03), or reported less daytime dysfunction (p=0.08). Sleep quality did not moderate the association between PAEE change and eGWG. Conclusions: Weight management interventions in pregnancy should consider screening for and addressing poor sleep in the second trimester.
Published: 2022
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32. Sleep characteristics modify the associations of physical activity during pregnancy and gestational weight gain

Author: Marquis S, Hawkins, Rachel K, Conlon, Shannon, Donofry, Daniel J, Buysse, Elizabeth M, Venditti, Yu, Cheng, and Michele D, Levine
Abstract: Excessive gestational weight gain (eGWG) is associated with adverse long-term maternal outcomes. Most lifestyle interventions that incorporate physical activity have been ineffective at reducing eGWG. The purpose of this study was to determine if sleep modified the relationships between physical activity change from the 2nd to 3rd trimester and the odds of excessive gestational weight gain (eGWG).This was a secondary data analysis of a prospective cohort study of pregnant birthing people with overweight or obesity (n = 105). We estimated physical activity energy expenditure (PAEE) in the 2nd and 3rd trimesters of pregnancy and sleep characteristics (i.e., sleep quality, daytime dysfunction, sleep efficiency, sleep duration) in the 2nd trimester of pregnancy with validated measures. We used regression models with sleep and PAEE change (increase/stable vs. decrease) interaction terms to examine the impact of sleep on PAEE change and eGWG.Mean GWG was 37.02 ± 16.76 lbs. and 80% of participants experienced eGWG. Eighteen percent of participants increased their PAEE from the 2nd to the 3rd trimester. Increasing (vs. decreasing) PAEE was associated with lower log-odds of eGWG only among participants that slept at least 8 h/night (p = 0.06), had at least 85% sleep efficiency (p = 0.03), or reported less daytime dysfunction (p = 0.08). Sleep quality did not moderate the association between PAEE change and eGWG.Weight management interventions in pregnancy should consider screening for and addressing poor sleep in the second trimester.
Published: 2022

33. Mediating Effects of Neural Targets on Depression, Weight, and Anxiety Outcomes of an Integrated Collaborative Care Intervention: The ENGAGE-2 Mechanistic Pilot Randomized Clinical Trial

Author: Nan Lv, Olusola A. Ajilore, Lan Xiao, Elizabeth M. Venditti, Philip W. Lavori, Ben S. Gerber, Mark B. Snowden, Nancy E. Wittels, Corina R. Ronneberg, Patrick Stetz, Amruta Barve, Rohit Shrestha, Sushanth Dosala, Vikas Kumar, Tessa L. Eckley, Andrea N. Goldstein-Piekarski, Joshua M. Smyth, Lisa G. Rosas, Thomas Kannampallil, John Zulueta, Trisha Suppes, Leanne M. Williams, and Jun Ma
Subjects: General Medicine
Published: 2022
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34. Program Factors Affecting Weight Loss and Mobility in Older Adults: Evidence From the Mobility and Vitality Lifestyle Program (MOVE UP)

Author: Xinran Liu, Lori A. Kieffer, Jennifer King, Brandi Boak, Janice C. Zgibor, Kenneth J. Smith, Lora E. Burke, John M. Jakicic, Linda N. Semler, Michelle E. Danielson, Anne B. Newman, Elizabeth M. Venditti, and Steven M. Albert
Subjects: Nursing (miscellaneous), Public Health, Environmental and Occupational Health
Abstract: Background. The Mobility and Vitality Lifestyle Program (MOVE UP) is a behavioral weight-management intervention for improving mobility among community-dwelling older adults. We examined program factors that affect implementation outcomes and participant-level health outcomes. Methods. The MOVE UP program was implemented in the greater Pittsburgh area from January 2015 to June 2019 to improve lower extremity performance in community-dwelling older adults who were overweight or obese. Thirty-two sessions were delivered over 13 months. All sessions were designed to be 1-hour in length, on-site, group-based, and led by trained and supported community health workers (CHWs). Participants completed weekly Lifestyle Logs for self-monitoring of body weight, diet, and physical activity. We evaluated the MOVE UP program using the RE-AIM framework, and collected quantitative data at baseline, 5-, 9-, and 13-months. Multilevel linear regression models assessed the impacts of program factors (site, CHW, and participant characteristics) on implementation outcomes and participant-level health outcomes. Results. Twenty-two CHWs delivered MOVE UP program to 303 participants in 26 cohorts. Participants were similar to the target source population in weight but differed in some demographic characteristics. The program was effective for weight loss and lower extremity function in both intervention and maintenance periods (Ps < .01), with an independent effect for Lifestyle Logs submission but not session attendance. Discussion. CHWs were able to deliver a multi-component weight loss intervention effectively in community settings. CHW and site characteristics had independent impacts on participants’ adherence. Lifestyle Log submission may be a more potent measure of adherence in weight loss interventions than attendance.
Published: 2023
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35. Study of quark and gluon jet substructure in Z plus jet and dijet events from pp collisions

Author: Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Dragicevic, M. Del Valle, A. Escalante and Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I Paulitsch, P. Pitters, F. M. Schieck, J. and Schofbeck, R. Spanring, M. Templ, S. Waltenberger, W. and Wulz, C-E Chekhovsky, V Litomin, A. Makarenko, V and Darwish, M. R. De Wolf, E. A. Janssen, T. Kello, T. and Lelek, A. Sfar, H. Rejeb Van Mechelen, P. Van Putte, S. and Van Remortel, N. Blekman, F. Bols, E. S. D'Hondt, J. and Delcourt, M. El Faham, H. Lowette, S. Moortgat, S. and Morton, A. Muller, D. Sahasransu, A. R. Tavernier, S. and Van Doninck, W. Van Mulders, P. Stylianou, N. Beghin, D. and Bilin, B. Clerbaux, B. De Lentdecker, G. Favart, L. and Grebenyuk, A. Kalsi, A. K. Lee, K. Mahdavikhorrami, M. and Makarenko, I Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. Vannerom, D. Wezenbeek, L. Gao, X. and Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. and Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. and Bethani, A. Bruno, G. Bury, F. Caputo, C. David, P. and Delaere, C. Donertas, I. S. Giammanco, A. Jaffel, K. and Jain, Sa Lemaitre, V Mondal, K. Prisciandaro, J. and Taliercio, A. Teklishyn, M. Tran, T. T. Vischia, P. and Wertz, S. Alves, G. A. Hensel, C. Moraes, A. Alda Junior, W. L. Gallo Pereira, M. Alves Ferreira Filho, M. Barroso and Malbouisson, H. Brandao Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. Damiao, D. De Jesus De Souza, S. Fonseca Figueiredo, D. Matos Herrera, C. Mora and Amarilo, K. Mota Mundim, L. Nogima, H. Teles, P. Rebello and Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. and Da Silva De Araujo, F. Torres Pereira, A. Vilela Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. and Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. and Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Cheng, T. Guo, Q. Javaid, T. Mittal, M. Wang, H. Yuan, L. Ahmad, M. Bauer, G. and Dozen, C. Hu, Z. Martins, J. Wang, Y. Yi, K. and Chapon, E. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. and Kapoor, A. Leggat, D. Liao, H. Liu, Z-A Milosevic, V and Monti, F. Sharma, R. Tao, J. Thomas-wilsker, J. and Wang, J. Zhang, H. Zhang, S. Zhao, J. Agapitos, A. and An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. and Mao, Y. Qian, S. J. Wang, D. Wang, Q. Xiao, J. Lu, M. You, Z. Okawa, H. Lin, Z. Xiao, M. Avila, C. and Cabrera, A. Florez, C. Fraga, J. Guisao, J. Mejia and Ramirez, F. Alvarez, J. D. Ruiz Gonzalez, C. A. Salazar and Giljanovic, D. Godinovic, N. Lelas, D. Puljak, I and Antunovic, Z. Kovac, M. Sculac, T. Brigljevic, V and Ferencek, D. Majumder, D. Roguljic, M. Starodumov, A. and Susa, T. Attikis, A. Christoforou, K. Erodotou, E. and Ioannou, A. Kole, G. Kolosova, M. Konstantinou, S. and Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. and Rykaczewski, H. Saka, H. Finger, M. Finger Jr, M. Jr and Kveton, A. Ayala, E. Carrera Jarrin, E. Abdalla, H. Abu Zeid, S. Mahmoud, M. A. Mohammed, Y. Bhowmik, S. and Dewanjee, R. K. Ehataht, K. Kadastik, M. Nandan, S. and Nielsen, C. Pata, J. Raidal, M. Tani, L. Veelken, C. and Eerola, P. Forthomme, L. Kirschenmann, H. Osterberg, K. and Voutilainen, M. Bharthuar, S. Brucken, E. Garcia, F. and Havukainen, J. Kim, M. S. Kinnunen, R. Lampen, T. and Lassila-Perini, K. Lehti, S. Linden, T. Lotti, M. and Martikainen, L. Myllymaki, M. Ott, J. Siikonen, H. and Tuominen, E. Tuominiemi, J. Luukka, P. Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. and Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. and Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Mijuskovic, J. Ahuja, S. Beaudette, F. Bonanomi, M. and Perraguin, A. Buchot Busson, P. Cappati, A. Charlot, C. and Davignon, O. Diab, B. Falmagne, G. Ghosh, S. de Cassagnac, R. Granier Hakimi, A. Kucher, I Motta, J. and Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sauvan, J. B. Sirois, Y. Tarabini, A. Zabi, A. and Zghiche, A. Agram, J-L Andrea, J. Apparu, D. Bloch, D. and Bourgatte, G. Brom, J-M Chabert, E. C. Collard, C. and Darej, D. Fontaine, J-C Goerlach, U. Grimault, C. Le Bihan, A-C Nibigira, E. Van Hove, P. Asilar, E. and Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. and Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V Torterotot, L. and Touquet, G. Vander Donckt, M. Viret, S. Lomidze, I and Toriashvili, T. Tsamalaidze, Z. Mestvirishvili, A. Feld, L. and Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rauch, M. P. Roewert, N. Schulz, J. Teroerde, M. Dodonova, A. and Eliseev, D. Erdmann, M. Fackeldey, P. Fischer, B. and Hebbeker, T. Hoepfner, K. Ivone, F. Keller, H. and Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Mocellin, G. and Mondal, S. Mukherjee, S. Noll, D. Novak, A. Pook, T. and Pozdnyakov, A. Rath, Y. Reithler, H. Roemer, J. Schmidt, A. Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. Zaleski, S. Borras, K. Kasem, A. Coubez, X. and Dziwok, C. Flugge, G. Ahmad, W. Haj Hlushchenko, O. and Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. and Sert, H. Stahl, A. Ziemons, T. Petersen, H. Aarup and Martin, M. Aldaya Asmuss, P. Babounikau, I Baxter, S. and Behnke, O. Martinez, A. Bermudez Bhattacharya, S. Bin Anuar, A. A. Botta, V Brunner, D. Campbell, A. Cardini, A. and Cheng, C. Colombina, F. Rodriguez, S. Consuegra Silva, G. Correia Danilov, V Didukh, L. Eckerlin, G. Eckstein, D. and Banos, L. I. Estevez Filatov, O. Gallo, E. Geiser, A. and Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. and Jomhari, N. Z. Jung, H. Kasemann, M. Kaveh, H. and Kleinwort, C. Krucker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I-A Morentin, M. Mendizabal Metwally, J. Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Adan, D. Perez Pitzl, D. and Raspereza, A. Lopes, B. Ribeiro Rubenach, J. Saggio, A. and Saibel, A. Savitskyi, M. Scham, M. Scheurer, V and Schutze, P. Schwanenberger, C. Singh, A. Ricardo, R. E. Sosa and Stafford, D. Tonon, N. Turkot, O. Van De Klundert, M. and Walsh, R. Walter, D. Wen, Y. Wichmann, K. Wiens, L. and Wissing, C. Wuchterl, S. Bakhshiansohi, H. Aggleton, R. and Albrecht, S. Bein, S. Benato, L. Benecke, A. Connor, P. De Leo, K. Eich, M. Feindt, F. Froehlich, A. and Garbers, C. Garutti, E. Gunnellini, P. Haller, J. and Hinzmann, A. Kasieczka, G. Klanner, R. Kogler, R. and Kramer, T. Kutzner, V Lange, J. Lange, T. Lobanov, A. and Malara, A. Nigamova, A. Rodriguez, K. J. Pena Rieger, O. and Schleper, P. Schroeder, M. Schwandt, J. Schwarz, D. and Sonneveld, J. Stadie, H. Steinbrueck, G. Tews, A. and Vormwald, B. Zoi, I Bechtel, J. Berger, T. Butz, E. and Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. Faltermann, N. Giffels, M. Gosewisch, J. O. Gottmann, A. Hartmann, F. Heidecker, C. Husemann, U. Keicher, P. Koppenhofer, R. Maier, S. Metzler, M. and Mitra, S. Mueller, Th Neukum, M. Nurnberg, A. Quast, G. and Rabbertz, K. Rauser, J. Savoiu, D. Schnepf, M. and Seith, D. Shvetsov, I Simonis, H. J. Ulrich, R. Van der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. and Wieland, S. Wolf, R. Wozniewski, S. Wunsch, S. and Anagnostou, G. Daskalakis, G. Geralis, T. Kyriakis, A. and Loukas, D. Stakia, A. Diamantopoulou, M. Karasavvas, D. and Karathanasis, G. Kontaxakis, P. Koraka, C. K. and Manousakis-katsikakis, A. Panagiotou, A. Papavergou, I and Saoulidou, N. Theofilatos, K. Tziaferi, E. 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A. Bloom, K. and Bryson, M. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. and Joo, C. Kravchenko, I Musich, M. Reed, I Siado, J. E. Snow, G. R. Tabb, W. Yan, F. Agarwal, G. and Bandyopadhyay, H. Hay, L. Iashvili, I. Kharchilava, A. and McLean, C. Nguyen, D. Pekkanen, J. Rappoccio, S. and Williams, A. Alverson, G. Barberis, E. Haddad, Y. and Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D. M. Nguyen, V Orimoto, T. Parker, A. Skinnari, L. and Tishelman-Charny, A. Wamorkar, T. Wang, B. Wisecarver, A. and Wood, D. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. and Hahn, K. A. Liu, Y. Odell, N. Schmitt, M. H. and Velasco, M. Band, R. Bucci, R. Das, A. Dev, N. and Goldouzian, R. Hildreth, M. Anampa, K. Hurtado Jessop, C. and Lannon, K. Lawrence, J. Loukas, N. Lutton, D. and Marinelli, N. Mcalister, I McCauley, T. Mcgrady, C. and Meng, F. Mohrman, K. Ruchti, R. Siddireddy, P. Townsend, A. Wayne, M. Wightman, A. Wolf, M. Zarucki, M. and Zygala, L. Bylsma, B. Cardwell, B. Durkin, L. 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Gershtein, Y. and Halkiadakis, E. Hart, A. Heindl, M. Karacheban, O. and Laflotte, I Lath, A. Montalvo, R. Nash, K. Osherson, M. and Salur, S. Schnetzer, S. Somalwar, S. Stone, R. and Thayil, S. A. Thomas, S. Acharya, H. Delannoy, A. G. and Fiorendi, S. Spanier, S. Bouhali, O. Dalchenko, M. and Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Luo, S. and Malhotra, S. Mueller, R. Overton, D. Rathjens, D. and Safonov, A. Akchurin, N. Damgov, J. Hegde, V Kunori, S. and Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. and Volobouev, I Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. and Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. and Ledovskoy, A. Li, A. Neu, C. Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. Bose, T. Caillol, C. Dasu, S. De Bruyn, I Everaerts, P. Fienga, F. and Galloni, C. He, H. Herndon, M. Herve, A. Hussain, U. and Lanaro, A. Loeliger, A. Loveless, R. Sreekala, J. Madhusudanan Mallampalli, A. Mohammadi, A. Pinna, D. and Savin, A. Shang, V Smith, W. H. Teague, D. and Trembath-reichert, S. Vetens, W. CMS Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract: Measurements of jet substructure describing the composition of quark- and gluon-initiated jets are presented. Proton-proton (pp) collision data at root s = 13 TeV collected with the CMS detector are used, corresponding to an integrated luminosity of 35.9 fb(-1). Generalized angularities are measured that characterize the jet substructure and distinguish quark- and gluon-initiated jets. These observables are sensitive to the distributions of transverse momenta and angular distances within a jet. The analysis is performed using a data sample of dijet events enriched in gluon-initiated jets, and, for the first time, a Z+jet event sample enriched in quark-initiated jets. The observables are measured in bins of jet transverse momentum, and as a function of the jet radius parameter. Each measurement is repeated applying a “soft drop” grooming procedure that removes soft and large angle radiation from the jet. Using these measurements, the ability of various models to describe jet substructure is assessed, showing a clear need for improvements in Monte Carlo generators.
Published: 2022

36. Measurement and QCD analysis of double-differential inclusive jet cross sections in proton-proton collisions at root s=13 TeV

Author: Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C. -E. Chekhovsky, V. Litomin, A. and Makarenko, V. Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Rejeb Sfar, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. and Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I. and Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. and Vanlaer, P. Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. and Benecke, A. Bethani, A. Bruno, G. Bury, F. Caputo, C. and David, P. Delaere, C. Donertas, I. S. Giammanco, A. and Jaffel, K. Jain, Sa. Lemaitre, V. Mondal, K. and Prisciandaro, J. Taliercio, A. Teklishyn, M. Tran, T. T. and Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. and Alda Junior, W. L. Alves Gallo Pereira, M. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. and Fonseca De Souza, S. Mora Herrera, C. Mota Amarilo, K. and Mundim, L. Nogima, H. Rebello Teles, P. Santoro, A. and Silva Do Amaral, S. M. Sznajder, A. Thiel, M. Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C. A. and Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. and Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. and Petrov, A. Cheng, T. Javaid, T. Mittal, M. Yuan, L. and Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. and Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. and Chen, M. Iemmi, F. Kapoor, A. Leggat, D. Liao, H. and Liu, Z. -A. Milosevic, V. Monti, F. Sharma, R. Tao, J. and Thomas-Wilsker, J. Wang, J. Zhang, H. Zhao, J. and Agapitos, A. An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Wang, Q. and Xiao, J. Lu, M. You, Z. Gao, X. Okawa, H. Zhang, Y. and Lin, Z. Xiao, M. Avila, C. Cabrera, A. Florez, C. and Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. and Lelas, D. Puljak, I. Antunovic, Z. Kovac, M. Sculac, T. and Brigljevic, V. Ferencek, D. Majumder, D. Roguljic, M. and Starodumov, A. Susa, T. Attikis, A. Christoforou, K. and Erodotou, E. Ioannou, A. Kole, G. Kolosova, M. and Konstantinou, S. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Saka, H. Finger, M. Finger, Jr., M. Kveton, A. Ayala, E. Carrera Jarrin, E. Assran, Y. Ellithi Kamel, A. Mahmoud, M. A. Mohammed, Y. and Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Nandan, S. Nielsen, C. Pata, J. Raidal, M. Tani, L. and Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. and Osterberg, K. Voutilainen, M. Bharthuar, S. Brucken, E. and Garcia, F. Havukainen, J. Kim, M. S. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. and Lotti, M. Martikainen, L. Myllymaki, M. Ott, J. and Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. and Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. and Ganjour, S. Gras, P. Hamel de Monchenault, G. Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Ahuja, S. Beaudette, F. Bonanomi, M. Buchot Perraguin, A. and Busson, P. Cappati, A. Charlot, C. Davignon, O. and Diab, B. Falmagne, G. Ghosh, S. Granier de Cassagnac, R. and Hakimi, A. Kucher, I. Motta, J. Nguyen, M. Ochando, C. and Paganini, P. Rembser, J. Salerno, R. Sarkar, U. and Sauvan, J. B. Sirois, Y. Tarabini, A. Zabi, A. Zghiche, A. Agram, J. -L. Andrea, J. Apparu, D. Bloch, D. and Bourgatte, G. Brom, J. -M. Chabert, E. C. Collard, C. and Darej, D. Fontaine, J. -C. Goerlach, U. Grimault, C. Le Bihan, A. -C. Nibigira, E. Van Hove, P. Asilar, E. and Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. and Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V. Torterotot, L. and Touquet, G. Vander Donckt, M. Viret, S. Lomidze, I. and Toriashvili, T. Tsamalaidze, Z. Botta, V. Feld, L. and Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rowert, N. and Schulz, J. Teroerde, M. Dodonova, A. Eliseev, D. and Erdmann, M. Fackeldey, P. Fischer, B. Ghosh, S. and Hebbeker, T. Hoepfner, K. Ivone, F. Mastrolorenzo, L. and Merschmeyer, M. Meyer, A. Mocellin, G. Mondal, S. and Mukherjee, S. Noll, D. Novak, A. Pook, T. Pozdnyakov, A. and Rath, Y. Reithler, H. Roemer, J. Schmidt, A. and Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. and Zaleski, S. Dziwok, C. Flugge, G. Haj Ahmad, W. and Hlushchenko, O. Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Ziemons, T. Zotz, A. and Aarup Petersen, H. Aldaya Martin, M. Asmuss, P. Baxter, S. Bayatmakou, M. Behnke, O. Bermudez Martinez, A. and Bhattacharya, S. Bin Anuar, A. A. Borras, K. Brunner, D. and Campbell, A. Cardini, A. Cheng, C. Colombina, F. and Consuegra Rodriguez, S. Correia Silva, G. Danilov, V. De Silva, M. Didukh, L. Eckerlin, G. Eckstein, D. Eren, E. and Estevez Banos, L. I. Filatov, O. Gallo, E. Gao, J. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. and Kaveh, H. Kleinwort, C. Kruecker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Maekelae, T. Mankel, R. and Melzer-Pellmann, I. -A. Mendizabal Morentin, M. Metwally, J. and Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Perez Adan, D. Pitzl, D. Raspereza, A. Ribeiro Lopes, B. Ruebenach, J. Saggio, A. Saibel, A. Savitskyi, M. and Scham, M. Scheurer, V. Schnake, S. Schuetze, P. and Schwanenberger, C. Shchedrolosiev, M. Sosa Ricardo, R. E. and Stafford, D. Tonon, N. Van De Klundert, M. Walsh, R. and Walter, D. Wen, Y. Wichmann, K. Wiens, L. Wissing, C. and Wuchterl, S. Zlebcik, R. Aggleton, R. Albrecht, S. and Bein, S. Benato, L. Connor, P. De Leo, K. Eich, M. and Feindt, F. Froehlich, A. Garbers, C. Garutti, E. and Gunnellini, P. Hajheidari, M. Haller, J. Hinzmann, A. and Kasieczka, G. Klanner, R. Kogler, R. Kramer, T. Kutzner, V. Lange, J. Lange, T. Lobanov, A. Malara, A. and Nigamova, A. Pena Rodriguez, K. J. Rieger, O. 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Spiegel, L. and Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, N. V. Uplegger, L. Vaandering, E. W. Weber, H. A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. Cherepanov, V. and Errico, F. Field, R. D. Guerrero, D. Joshi, B. M. and Kim, M. Koenig, E. Konigsberg, J. Korytov, A. Lo, K. H. and Matchev, K. Menendez, N. Mitselmakher, G. Muthirakalayil Madhu, A. Rawal, N. Rosenzweig, D. Rosenzweig, S. and Rotter, J. Shi, K. Sturdy, J. Wang, J. Yigitbasi, E. and Zuo, X. Adams, T. Askew, A. Habibullah, R. Hagopian, V. and Johnson, K. F. Khurana, R. Kolberg, T. Martinez, G. and Prosper, H. Schiber, C. Viazlo, O. Yohay, R. Zhang, J. and Baarmand, M. M. Butalla, S. Elkafrawy, T. Hohlmann, M. and Kumar Verma, R. Noonan, D. Rahmani, M. Yumiceva, F. and Adams, M. R. Becerril Gonzalez, H. Cavanaugh, R. Dittmer, S. and Evdokimov, O. Gerber, C. E. Hangal, D. A. Hofman, D. J. and Merrit, A. H. Mills, C. Oh, G. Roy, T. Rudrabhatla, S. Tonjes, M. B. Varelas, N. Viinikainen, J. Wang, X. and Wu, Z. Ye, Z. Alhusseini, M. Dilsiz, K. Gandrajula, R. P. Koseyan, O. K. Merlo, J. -P. Mestvirishvili, A. and Nachtman, J. Ogul, H. Onel, Y. Penzo, A. Snyder, C. and Tiras, E. Amram, O. Blumenfeld, B. Corcodilos, L. Davis, J. Eminizer, M. Gritsan, A. V. Kyriacou, S. Maksimovic, P. Roskes, J. Swartz, M. Vami, T. A. Abreu, A. and Anguiano, J. Baldenegro Barrera, C. Baringer, P. Bean, A. and Bylinkin, A. Flowers, Z. Isidori, T. Khalil, S. and King, J. Krintiras, G. Kropivnitskaya, A. Lazarovits, M. and Le Mahieu, C. Lindsey, C. Marquez, J. Minafra, N. and Murray, M. Nickel, M. Rogan, C. Royon, C. Salvatico, R. and Sanders, S. Schmitz, E. Smith, C. Tapia Takaki, J. D. and Wang, Q. Warner, Z. Williams, J. Wilson, G. Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. and Mitchell, T. Modak, A. Nam, K. Rebassoo, F. Wright, D. and Adams, E. Baden, A. Baron, O. Belloni, A. Eno, S. C. and Hadley, N. J. Jabeen, S. Kellogg, R. G. Koeth, T. and Mignerey, A. C. Nabili, S. Palmer, C. Seidel, M. Skuja, A. Wang, L. Wong, K. Abercrombie, D. Andreassi, G. and Bi, R. Busza, W. Cali, I. A. Chen, Y. D'Alfonso, M. and Eysermans, J. Freer, C. Gomez Ceballos, G. Goncharov, M. and Harris, P. Hu, M. Klute, M. Kovalskyi, D. Krupa, J. and Lee, Y. -J. Mironov, C. Paus, C. Rankin, D. Roland, C. and Roland, G. Shi, Z. Stephans, G. S. F. Wang, J. Wang, Z. Wyslouch, B. Chatterjee, R. M. Evans, A. Hiltbrand, J. Jain, Sh. Krohn, M. Kubota, Y. Mans, J. Revering, M. Rusack, R. Saradhy, R. Schroeder, N. Strobbe, N. and Wadud, M. A. Bloom, K. Bryson, M. Chauhan, S. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Joo, C. and Kravchenko, I. Musich, M. Reed, I. Siado, J. E. Snow, G. R. Tabb, W. Yan, F. Zecchinelli, A. G. Agarwal, G. and Bandyopadhyay, H. Hay, L. Iashvili, I. Kharchilava, A. and McLean, C. Nguyen, D. Pekkanen, J. Rappoccio, S. and Williams, A. Alverson, G. Barberis, E. Haddad, Y. and Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D. M. Nguyen, V. Orimoto, T. Parker, A. Skinnari, L. and Tishelman-Charny, A. Wamorkar, T. Wang, B. Wisecarver, A. and Wood, D. Bhattacharya, S. Bueghly, J. Chen, Z. and Gilbert, A. Gunter, T. Hahn, K. A. Liu, Y. Odell, N. and Schmitt, M. H. Velasco, M. Band, R. Bucci, R. Cremonesi, M. Das, A. Dev, N. Goldouzian, R. Hildreth, M. and Hurtado Anampa, K. Jessop, C. Lannon, K. Lawrence, J. and Loukas, N. Lutton, D. Marinelli, N. Mcalister, I. and McCauley, T. Mcgrady, C. Mohrman, K. Moore, C. Musienko, Y. Ruchti, R. Siddireddy, P. Townsend, A. Wayne, M. and Wightman, A. Zarucki, M. Zygala, L. Bylsma, B. Cardwell, B. Durkin, L. S. Francis, B. Hill, C. Nunez Ornelas, M. and Wei, K. Winer, B. L. Yates, B. R. Addesa, F. M. and Bonham, B. Das, P. Dezoort, G. Elmer, P. Frankenthal, A. and Greenberg, B. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kopp, G. Kwan, S. Lange, D. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Stickland, D. Tully, C. Malik, S. Norberg, S. Bakshi, A. S. Barnes, V. E. and Chawla, R. Das, S. Gutay, L. Jones, M. Jung, A. W. and Karmarkar, S. Kondratyev, D. Liu, M. Negro, G. and Neumeister, N. Paspalaki, G. Piperov, S. Purohit, A. and Schulte, J. F. Stojanovic, M. Thieman, J. Wang, F. Xiao, R. Xie, W. Dolen, J. Parashar, N. Baty, A. Carnahan, T. Decaro, M. Dildick, S. Ecklund, K. M. Freed, S. and Gardner, P. Geurts, F. J. M. Kumar, A. Li, W. Padley, B. P. Redjimi, R. Shi, W. Stahl Leiton, A. G. Yang, S. and Zhang, L. Zhang, Y. Bodek, A. de Barbaro, P. Demina, R. and Dulemba, J. L. Fallon, C. Ferbel, T. Galanti, M. and Garcia-Bellido, A. Hindrichs, O. Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. Chou, J. P. Gandrakota, A. and Gershtein, Y. Halkiadakis, E. Hart, A. Heindl, M. and Karacheban, O. Laflotte, I. Lath, A. Montalvo, R. Nash, K. Osherson, M. Salur, S. Schnetzer, S. Somalwar, S. and Stone, R. Thayil, S. A. Thomas, S. Wang, H. Acharya, H. and Delannoy, A. G. Fiorendi, S. Spanier, S. Bouhali, O. and Dalchenko, M. Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Kim, H. Luo, S. Malhotra, S. Mueller, R. Overton, D. Rathjens, D. Safonov, A. Akchurin, N. and Damgov, J. Hegde, V. Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. Peltola, T. Volobouev, I. and Wang, Z. Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. and Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. and Ledovskoy, A. Li, A. Neu, C. Perez Lara, C. E. and Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. and Bose, T. Caillol, C. Dasu, S. De Bruyn, I. and Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. and Herve, A. Hussain, U. Lanaro, A. Loeliger, A. and Loveless, R. Madhusudanan Sreekala, J. Mallampalli, A. and Mohammadi, A. Pinna, D. Savin, A. Shang, V. Sharma, V. and Smith, W. H. Teague, D. Trembath-Reichert, S. Vetens, W. and CMS Collaboration
Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: A measurement of the inclusive jet production in proton-proton collisions at the LHC at root s = 13TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum p(T) and the absolute jet rapidity vertical bar y vertical bar. The anti- k(T) clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet p(T) from 97 GeV up to 3.1TeV and vertical bar y vertical bar < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb(-1) (33.5 fb(-1)). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the parton distributions in the proton. Simultaneously, the value of the strong coupling constant at the Z boson mass is extracted as alpha(S)(m(Z)) = 0.1170 +/- 0.0019. For the first time, these data are used in a standard model effective field theory analysis at next-to-leading order, where parton distributions and the QCD parameters are extracted simultaneously with imposed constraints on the Wilson coefficient c(1) of 4-quark contact interactions.
Published: 2022

37. Effect of ceftazidime/avibactam plus fosfomycin combination on 30 day mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae: results from a multicentre retrospective study

Author: A Oliva, L Volpicelli, S Di Bari, A Curtolo, C Borrazzo, F Cogliati Dezza, A Cona, S Agrenzano, A Mularoni, M Trancassini, F Mengoni, S Stefani, G Raponi, and M Venditti
Subjects: Microbiology (medical), Infectious Diseases, Immunology, Immunology and Allergy, Microbiology
Abstract: Introduction The primary outcome of the study was to evaluate the effect on 30 day mortality of the combination ceftazidime/avibactam + fosfomycin in the treatment of bloodstream infections (BSIs) caused by KPC-producing Klebsiella pneumoniae (KPC-Kp). Materials and methods From October 2018 to March 2021, a retrospective, two-centre study was performed on patients with KPC-Kp BSI hospitalized at Sapienza University (Rome) and ISMETT-IRCCS (Palermo) and treated with ceftazidime/avibactam-containing regimens. A matched cohort (1:1) analysis was performed. Cases were patients receiving ceftazidime/avibactam + fosfomycin and controls were patients receiving ceftazidime/avibactam alone or in combination with in vitro non-active drugs different from fosfomycin (ceftazidime/avibactam ± other). Patients were matched for age, Charlson comorbidity index, ward of isolation (ICU or non-ICU), source of infection and severity of BSI, expressed as INCREMENT carbapenemase-producing Enterobacteriaceae (CPE) score. Results Overall, 221 patients were included in the study. Following the 1:1 match, 122 subjects were retrieved: 61 cases (ceftazidime/avibactam + fosfomycin) and 61 controls (ceftazidime/avibactam ± other). No difference in overall mortality emerged between cases and controls, whereas controls had more non-BSI KPC-Kp infections and a higher number of deaths attributable to secondary infections. Almost half of ceftazidime/avibactam + fosfomycin patients were prescribed fosfomycin without MIC fosfomycin availability. No difference in the outcome emerged after stratification for fosfomycin susceptibility availability and dosage. SARS-CoV-2 infection and ICS ≥ 8 independently predicted 30 day mortality, whereas an appropriate definitive therapy was protective. Conclusions Our data show that fosfomycin was used in the treatment of KPC-Kp BSI independently from having its susceptibility testing available. Although no difference was found in 30 day overall mortality, ceftazidime/avibactam + fosfomycin was associated with a lower rate of subsequent KPC-Kp infections and secondary infections than other ceftazidime/avibactam-based regimens.
Published: 2022

38. Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Dragicevic, M. Ero, J. Del Valle, A. Escalante and Flechl, M. Fruhwirth, R. Jeitler, M. Krammer, N. and Kratschmer, I Liko, D. Madlener, T. Mikulec, I Rad, N. and Schieck, J. Schofbeck, R. Spanring, M. Waltenberger, W. and Wulz, C-E Zarucki, M. Drugakov, V Mossolov, V and Gonzalez, J. Suarez Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. Kello, T. Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. and Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. and D'Hondt, J. De Clercq, J. Lontkovskyi, D. Lowette, S. and Marchesini, I Moortgat, S. Python, Q. Tavernier, S. and Van Doninck, W. Van Mulders, P. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. and Favart, L. Grebenyuk, A. Kalsi, A. K. Moureaux, L. and Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I Niedziela, M. Roskas, C. Skovpen, K. and Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Lemaitre, V Prisciandaro, J. Saggio, A. and Vischia, P. Zobec, J. Alves, G. A. Silva, G. Correia and Hensel, C. Moraes, A. Batista Das Chagas, E. Belchior and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. Damiao, D. De Jesus Martins, C. De Oliveira and De Souza, S. Fonseca Malbouisson, H. Martins, J. and Figueiredo, D. Matos Jaime, M. Medina De Almeida, M. Melo and Herrera, C. Mora Mundim, L. Nogima, H. Prado Da Silva, W. L. and Teles, P. Rebello Rosas, L. J. Sanchez Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Da Silva De Araujo, F. Torres Pereira, A. Vilela Bernardes, C. A. and Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. and Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Bonchev, M. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. and Petkov, P. Petrov, A. Fang, W. Gao, X. Yuan, L. and Ahmad, M. Hu, Z. Wang, Y. Chen, G. M. Chen, H. S. and Chen, M. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Spiezia, A. Tao, J. Yazgan, E. Zhang, H. Zhang, S. and Zhao, J. Agapitos, A. Ban, Y. Chen, G. Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. and Wang, Q. Xiao, M. Avila, C. Cabrera, A. Florez, C. and Gonzalez Hernandez, C. F. Segura Delgado, M. A. Mejia Guisao, J. and Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Vanegas Arbelaez, N. Godinovic, N. Lelas, D. Puljak, I Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V Ferencek, D. and Kadija, K. Mesic, B. Roguljic, M. Starodumov, A. and Susa, T. Ather, M. W. Attikis, A. Erodotou, E. Ioannou, A. Kolosova, M. Konstantinou, S. Mavromanolakis, G. and Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. and Rykaczewski, H. Saka, H. Tsiakkouri, D. 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Huang, T. Kamon, T. Kim, H. Luo, S. and Malhotra, S. Marley, D. Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. and De Guio, F. Hegde, V Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. and Volobouev, I Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. and Padeken, K. Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. and Cummings, G. Hakala, J. Hirosky, R. Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. Wolfe, E. Xia, F. and Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. and Thapa, P. Black, K. Bose, T. Buchanan, J. Caillol, C. and Carlsmith, D. Dasu, S. De Bruyn, I Dodd, L. Galloni, C. He, H. Herndon, M. Herve, A. Hussain, U. Lanaro, A. Loeliger, A. Loveless, R. Sreekala, J. Madhusudanan and Mallampalli, A. Pinna, D. Ruggles, T. Savin, A. Sharma, V Smith, W. H. Teague, D. Trembath-reichert, S. CMS Collaboration
Subjects: High Energy Physics::Experiment
Abstract: The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.
Published: 2022

39. Measurement of double-parton scattering in inclusive production of four jets with low transverse momentum in proton-proton collisions at root s=13 TeV

Author: Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Dragicevic, M. Del Valle, A. Escalante and Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I Paulitsch, P. Pitters, F. M. Schieck, J. and Schofbeck, R. Spanring, M. Templ, S. Waltenberger, W. and Wulz, C-E Chekhovsky, V Litomin, A. Makarenko, V and Darwish, M. R. De Wolf, E. A. Janssen, X. Kello, T. and Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. and Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. and Bols, E. S. D'Hondt, J. De Clercq, J. Delcourt, M. and El Faham, H. Lowette, S. Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. Tavernier, S. Van Doninck, W. Van Mulders, P. Stylianou, N. Beghin, D. Bilin, B. Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I Moureaux, L. and Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. and Vannerom, D. Wezenbeek, L. Fang, W. Gao, X. Cornelis, T. and Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. and Niedziela, M. Roskas, C. Samalan, A. Skovpen, K. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Bethani, A. and Bruno, G. Bury, F. Caputo, C. David, P. Delaere, C. and Donertas, I. S. Giammanco, A. Jaffel, K. Jain, Sa and Lemaitre, V Mondal, K. Prisciandaro, J. Taliercio, A. and Teklishyn, M. Tran, T. T. Vischia, P. Wertz, S. and Wuyckens, S. Alves, G. A. Hensel, C. Moraes, A. Alda Junior, W. L. Gallo Pereira, M. Alves Ferreira Filho, M. Barroso and Mal-Bouisson, H. Brandao Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. Damiao, D. De Jesus De Souza, S. Fonseca Figueiredo, D. Matos Herrera, C. Mora and Amarilo, K. Mota Mundim, L. Nogima, H. Teles, P. Rebello and Santoro, A. Silva Do Amaral, S. M. Sznajder, A. Thiel, M. and Da Silva De Araujo, F. Torres Pereira, A. Vilela Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. and Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. and Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Cheng, T. Guo, Q. Javaid, T. Mittal, M. Wang, H. Yuan, L. Ahmad, M. Bauer, G. and Dozen, C. Hu, Z. Martins, J. Wang, Y. Yi, K. and Chapon, E. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. and Kapoor, A. Leggat, D. Liao, H. Liu, Z-A Milosevic, V and Monti, F. Sharma, R. Tao, J. Thomas-wilsker, J. and Wang, J. Zhang, H. Zhang, S. Zhao, J. Agapitos, A. and Ban, Y. Chen, C. Huang, Q. Levin, A. Li, Q. Lyu, X. and Mao, Y. Qian, S. J. Wang, D. Wang, Q. Xiao, J. and Lu, M. You, Z. Okawa, H. Lin, Z. Xiao, M. Avila, C. and Cabrera, A. Florez, C. Fraga, J. Sarkar, A. Segura Delgado, M. A. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. and Lelas, D. Puljak, I Antunovic, Z. Kovac, M. Sculac, T. and Brigljevic, V Ferencek, D. 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Karapinar, G. Ocalan, K. Yalvac, M. and Akgun, B. Atakisi, I. O. Gulmez, E. Kaya, M. Kaya, O. and Tekten, S. Yetkin, E. A. Cakir, A. Cankocak, K. and Komurcu, Y. Sen, S. Cerci, S. Kaynak, B. Ozkorucuklu, S. and Cerci, D. Sunar Grynyov, B. Levchuk, L. Anthony, D. and Bhal, E. Bologna, S. Brooke, J. J. Bundock, A. Clement, E. Cussans, D. Flacher, H. Goldstein, J. Heath, G. P. and Heath, H. F. Kreczko, L. Krikler, B. Paramesvaran, S. and El Nasr-Storey, S. Seif Smith, V. J. White, R. Bell, K. W. Brew, C. Brown, R. M. Cockerill, D. J. A. Ellis, V, K. Harder, K. Harper, S. Linacre, J. Manolopoulos, K. and Newbold, D. M. Olaiya, E. Petyt, D. Reis, T. Schuh, T. Shepherd-Themistocleous, C. H. Tomalin, I. R. Williams, T. Bainbridge, R. Bloch, P. Bonomally, S. Borg, J. and Breeze, S. Buchmuller, O. Cepaitis, V Chahal, G. S. and Colling, D. Dauncey, P. Davies, G. Della Negra, M. and Fayer, S. Fedi, G. Hall, G. Hassanshahi, M. H. Iles, G. and Langford, J. Lyons, L. Magnan, A-M Malik, S. and Martelli, A. Nash, J. Pesaresi, M. Raymond, D. M. and Richards, A. Rose, A. Scott, E. Seez, C. Shtipliyski, A. and Tapper, A. Uchida, K. Wardle, N. Webb, S. N. and Winterbottom, D. Zecchinelli, A. G. Coldham, K. Cole, J. E. and Khan, A. Kyberd, P. Reid, I. D. Teodorescu, L. and Zahid, S. Abdullin, S. Brinkerhoff, A. Caraway, B. and Dittmann, J. Hatakeyama, K. Kanuganti, A. R. McMaster, B. and Pastika, N. Sawant, S. Sutantawibul, C. Wilson, J. and Bartek, R. Dominguez, A. Uniyal, R. Hernandez, A. M. Vargas and Buccilli, A. Cooper, I, S. Di Croce, D. Gleyzer, V, S. and Henderson, C. Perez, C. U. West, C. Akpinar, A. and Albert, A. Arcaro, D. Cosby, C. Demiragli, Z. Fontanesi, E. Gastler, D. Rohlf, J. Salyer, K. Sperka, D. and Spitzbart, D. Suarez, I Tsatsos, A. Yuan, S. Zou, D. and Benelli, G. Burkle, B. Cutts, D. Hadley, M. Heintz, U. and Hogan, J. M. Landsberg, G. Lau, K. T. Lukasik, M. and Luo, J. Narain, M. Sagir, S. Usai, E. Wong, W. Y. and Yan, X. Yu, D. Zhang, W. Bonilla, J. Brainerd, C. and Breedon, R. Sanchez, M. Calderon De La Barca Chertok, M. and Conway, J. Cox, P. T. Erbacher, R. Haza, G. Jensen, F. and Kukral, O. Lander, R. Mulhearn, M. Pellett, D. and Regnery, B. Taylor, D. Yao, Y. Zhang, F. Bachtis, M. and Cousins, R. Datta, A. Hamilton, D. Hauser, J. Ignatenko, M. Iqbal, M. A. Lam, T. Mccoll, N. Nash, W. A. and Regnard, S. Saltzberg, D. Stone, B. Valuev, V. Burt, K. and Chen, Y. Clare, R. Gary, J. W. Gordon, M. Hanson, G. and Karapostoli, G. Long, O. R. Manganelli, N. Negrete, M. Olmedo Si, W. Wimpenny, S. Zhang, Y. Branson, J. G. and Chang, P. Cittolin, S. Cooperstein, S. Deelen, N. and Duarte, J. Gerosa, R. Giannini, L. Gilbert, D. Guiang, J. Kansal, R. Krutelyov, V Lee, R. Letts, J. and Masciovecchio, M. May, S. Pieri, M. Narayanan, B. V. Sathia and Sharma, V Tadel, M. Vartak, A. Wurthwein, F. Xiang, Y. Yagil, A. Amin, N. Campagnari, C. Citron, M. and Dorsett, A. Dutta, V Incandela, J. Kilpatrick, M. Marsh, B. Mei, H. Oshiro, M. Quinnan, M. Richman, J. and Sarica, U. Stuart, D. Wang, S. Bornheim, A. Cerri, O. and Dutta, I Lawhorn, J. M. Lu, N. Mao, J. Newman, H. B. and Ngadiuba, J. Nguyen, T. Q. Spiropulu, M. Vlimant, J. R. and Wang, C. Xie, S. Zhang, Z. Zhu, R. Y. Pena, C. and Alison, J. An, S. Andrews, M. B. Bryant, P. Ferguson, T. and Harilal, A. Liu, C. Mudholkar, T. Paulini, M. and Sanchez, A. Cumalat, J. P. Ford, W. T. Hassani, A. and MacDonald, E. Patel, R. Perloff, A. Savard, C. Stenson, K. Ulmer, K. A. Wagner, S. R. Alexander, J. and Bright-thonney, S. Cheng, Y. Cranshaw, D. J. Hogan, S. and Monroy, J. Patterson, J. R. Quach, D. Reichert, J. Reid, M. Ryd, A. Sun, W. Thom, J. Wittich, P. Zou, R. and Albrow, M. Alyari, M. Apollinari, G. Apresyan, A. Apyan, A. Bauerdick, L. A. T. Berry, D. Berryhill, J. Bhat, P. C. Burkett, K. Butler, J. N. Canepa, A. Cerati, G. B. and Cheung, H. W. K. Chlebana, F. Cremonesi, M. Di Petrillo, K. F. Elvira, V. D. Feng, Y. Freeman, J. Gecse, Z. and Gray, L. Green, D. Grunendahl, S. Gutsche, O. Harris, R. M. Heller, R. Herwig, T. C. Hirschauer, J. Jayatilaka, B. Jindariani, S. Johnson, M. Joshi, U. Klijnsma, T. and Klima, B. Kwok, K. H. M. Lammel, S. Lincoln, D. Lipton, R. Liu, T. Madrid, C. Maeshima, K. Mantilla, C. and Mason, D. McBride, P. Merkel, P. Mrenna, S. Nahn, S. and O'Dell, V Papadimitriou, V Pedro, K. Prokofyev, O. and Ravera, F. Hall, A. Reinsvold Ristori, L. Schneider, B. and Sexton-Kennedy, E. Smith, N. Soha, A. Spalding, W. J. and Spiegel, L. Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, V, N. Uplegger, L. Vaandering, E. W. Weber, H. A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. and Cherepanov, V Errico, F. Field, R. D. Guerrero, D. and Joshi, B. M. Kim, M. Koenig, E. Konigsberg, J. Korytov, A. Lo, K. H. Matchev, K. Menendez, N. Mitselmakher, G. and Madhu, A. Muthirakalayil Rawal, N. Rosenzweig, D. and Rosenzweig, S. Shi, K. Sturdy, J. Yigitbasi, E. Zuo, X. and Adams, T. Askew, A. Diaz, D. Habibullah, R. and Hagopian, V Johnson, K. F. Khurana, R. Kolberg, T. and Martinez, G. Prosper, H. Schiber, C. Yohay, R. Zhang, J. and Baarmand, M. M. Butalla, S. Elkafrawy, T. Hohlmann, M. and Verma, R. Kumar Noonan, D. Rahmani, M. Saunders, M. and Yumiceva, F. Adams, M. R. Gonzalez, H. Becerril Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C. E. and Hangal, D. A. Hofman, D. J. Merrit, A. H. Mills, C. Oh, G. Roy, T. Rudrabhatla, S. Tonjes, M. B. Varelas, N. and Viinikainen, J. Wang, X. Wu, Z. Ye, Z. Alhusseini, M. and Dilsiz, K. Gandrajula, R. P. Koseyan, O. K. Merlo, J-P and Nachtman, J. Ogul, H. Onel, Y. Penzo, A. Snyder, C. and Tiras, E. Amram, O. Blumenfeld, B. Corcodilos, L. and Davis, J. Eminizer, M. Gritsan, V, A. Kyriacou, S. and Maksimovic, P. Roskes, J. Swartz, M. Vami, T. A. and Anguiano, J. Barrera, C. Baldenegro Baringer, P. Bean, A. and Bylinkin, A. Isidori, T. Khalil, S. King, J. and Krintiras, G. Kropivnitskaya, A. Lindsey, C. Minafra, N. and Murray, M. Rogan, C. Royon, C. Salvatico, R. Sanders, S. and Schmitz, E. Smith, C. Takaki, J. D. Tapia Williams, J. and Wilson, G. Duric, S. Ivanov, A. Kaadze, K. Kim, D. and Maravin, Y. Mitchell, T. Modak, A. Nam, K. Rebassoo, F. Wright, D. Adams, E. Baden, A. Baron, O. Belloni, A. Eno, S. C. Hadley, N. J. Jabeen, S. Kellogg, R. G. and Koeth, T. Mignerey, A. C. Nabili, S. Seidel, M. and Skuja, A. Wang, L. Wong, K. Abercrombie, D. Andreassi, G. Bi, R. Brandt, S. Busza, W. Cali, I. A. and D'Alfonso, M. Eysermans, J. Ceballos, G. Gomez Goncharov, M. and Harris, P. Hu, M. Klute, M. Kovalskyi, D. Krupa, J. and Lee, Y-J Maier, B. Mironov, C. Paus, C. Rankin, D. and Roland, C. Roland, G. Shi, Z. Stephans, G. S. F. and Tatar, K. Wang, Z. Wyslouch, B. Chatterjee, R. M. Evans, A. Hansen, P. Hiltbrand, J. Jain, Sh Krohn, M. and Kubota, Y. Mans, J. Revering, M. Rusack, R. Saradhy, R. and Schroeder, N. Strobbe, N. Wadud, M. A. Bloom, K. and Bryson, M. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. and Fernandez, J. R. Gonzalez Joo, C. Kravchenko, I Musich, M. Reed, I Siado, J. E. Snow, G. R. Tabb, W. Yan, F. and Agarwal, G. Bandyopadhyay, H. Hay, L. Iashvili, I. and Kharchilava, A. McLean, C. Nguyen, D. Pekkanen, J. and Rappoccio, S. Williams, A. Alverson, G. Barberis, E. and Freer, C. Haddad, Y. Hortiangtham, A. Li, J. Madigan, G. and Marzocchi, B. Morse, D. M. Nguyen, V Orimoto, T. and Parker, A. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. Hahn, K. A. Odell, N. and Schmitt, M. H. Velasco, M. Band, R. Bucci, R. Das, A. and Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Hurtado and Jessop, C. Lannon, K. Loukas, N. Marinelli, N. and Mcalister, I McCauley, T. Meng, F. Mohrman, K. Ruchti, R. Siddireddy, P. Wayne, M. Wightman, A. Wolf, M. and Zarucki, M. Zygala, L. Bylsma, B. Cardwell, B. Durkin, L. S. Francis, B. Hill, C. Ornelas, M. Nunez Wei, K. and Winer, B. L. Yates, B. R. Addesa, F. M. Bonham, B. Das, P. Dezoort, G. Elmer, P. Frankenthal, A. Greenberg, B. and Haubrich, N. Higginbotham, S. Kalogeropoulos, A. Kopp, G. Kwan, S. Lange, D. Lucchini, M. T. Marlow, D. and Mei, K. Ojalvo, I Olsen, J. Palmer, C. Stickland, D. and Tully, C. Norberg, S. Bakshi, A. S. Barnes, V. E. and Chawla, R. Das, S. Gutay, L. Jones, M. Jung, A. W. and Karmarkar, S. Liu, M. Negro, G. Neumeister, N. and Paspalaki, G. Peng, C. C. Piperov, S. Purohit, A. and Schulte, J. F. Stojanovic, M. Thieman, J. Wang, F. Xiao, R. Xie, W. Dolen, J. Parashar, N. Baty, A. Decaro, M. Dildick, S. Ecklund, K. M. Freed, S. Gardner, P. and Geurts, F. J. M. Li, W. Padley, B. P. Redjimi, R. Shi, W. Leiton, A. G. Stahl Zhang, L. Bodek, A. de Barbaro, P. Demina, R. Dulemba, J. L. Fallon, C. Ferbel, T. and Galanti, M. Garcia-Bellido, A. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. and Chou, J. P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. and Hart, A. Heindl, M. Hughes, E. Kaplan, S. Laflotte, I and Lath, A. Montalvo, R. Nash, K. Osherson, M. Salur, S. Schnetzer, S. Somalwar, S. Stone, R. Thayil, S. A. and Thomas, S. Acharya, H. Delannoy, A. G. Spanier, S. and Bouhali, O. Dalchenko, M. Delgado, A. Eusebi, R. and Gilmore, J. Huang, T. Luo, S. Malhotra, S. Mueller, R. and Overton, D. Rathjens, D. Safonov, A. Akchurin, N. and Damgov, J. Hegde, V Kunori, S. Lamichhane, K. Mengke, T. and Muthumuni, S. Peltola, T. Volobouev, I Whitbeck, A. and Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. and Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. and Velkovska, J. Arenton, M. W. Cox, B. Cummings, G. and Hakala, J. Hirosky, R. Joyce, M. Ledovskoy, A. Li, A. and Neu, C. Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. Bose, T. Buchanan, J. Caillol, C. Dasu, S. De Bruyn, I Everaerts, P. Fienga, F. Galloni, C. and He, H. Herndon, M. Herve, A. Hussain, U. Lanaro, A. and Loeliger, A. Loveless, R. Sreekala, J. Madhusudanan and Mallampalli, A. Mohammadi, A. Pinna, D. Savin, A. Shang, V Smith, W. H. Teague, D. Trembath-reichert, S. Vetens, W. CMS Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract: A measurement of inclusive four-jet production in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. The transverse momenta of jets within vertical bar eta vertical bar 4.7 are required to exceed 35, 30, 25, and 20 GeV for the first-, second-, third-, and fourth-leading jet, respectively. Differential cross sections are measured as functions of the jet transverse momentum, jet pseudorapidity, and several other observables that describe the angular correlations between the jets. The measured distributions show sensitivity to different aspects of the underlying event, parton shower modeling, and matrix element calculations. In particular, the interplay between angular correlations caused by parton shower and double-parton scattering contributions is shown to be important. The double-parton scattering contribution is extracted by means of a template fit to the data, using distributions for single-parton scattering obtained from Monte Carlo event generators and a double-parton scattering distribution constructed from inclusive single-jet events in data. The effective double-parton scattering cross section is calculated and discussed in view of previous measurements and of its dependence on the models used to describe the single-parton scattering background.
Published: 2022

40. Integrated collaborative care intervention for depression and obesity in primary care: translation from research to practice

Author: Corina R Ronneberg, Nan Lv, Olusola A Ajilore, Ben S Gerber, Elizabeth M Venditti, Mark B Snowden, Lesley E Steinman, Nancy E Wittels, Amruta Barve, Sushanth Dosala, Lisa G Rosas, Emily A Kringle, and Jun Ma
Subjects: Primary Health Care, Depression, Public Health, Environmental and Occupational Health, COVID-19, Humans, Obesity, Education, Telephone
Abstract: The objective of this study was to present lessons learned about engagement, delivery modality and pandemic impact while delivering a collaborative care intervention with a socioeconomically, racially and ethnically diverse sample. Participants completed a post-intervention survey (n = 41) on experiences and preferred intervention delivery modality, coronavirus 2019 (COVID-19) Impact Survey (n = 50) and provided open-ended feedback about the intervention (n = 27). Intervention process data included attendance, modality, and withdrawals. Data were analyzed using descriptive statistics and inductive content analyses. Of 71 intervention participants, 6 (8%) withdrew before session 1. Completers adhered to intervention timeline better than withdrawals. Participants liked the in-person interaction, efficient coach support, accountability of in-person and Zoom vs. phone sessions and the flexibility and convenience of phone and Zoom vs. in-person sessions. A majority of participants reported experiencing pandemic impacts such as heightened emotional distress, decreased activity engagement, poorer eating behaviors and being unable to meet basic needs. Participants deviating from intervention timelines may be re-engaged by targeted outreach attempts. Videoconference has the potential for providing as-needed coaching. Future interventions may be optimized to account for and address areas impacted by the pandemic. Findings revealed specific strategies that can be implemented in future interventions to improve emotional and physical health among diverse populations.
Published: 2021

41. Impact of Maintenance Session Attendance and Early Weight Loss Goal Achievement on Weight Loss Success in a Community-Based Diabetes Prevention Program Intervention

Author: Susan M. Devaraj, Elizabeth M. Venditti, Rachel G. Miller, Elsa S. Strotmeyer, Andrea M. Kriska, Bonny Rockette-Wagner, Jenna M. Napoleone, Vincent C. Arena, and Kaye Kramer
Subjects: Gerontology, Male, Health (social science), Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Medicare, Health Professions (miscellaneous), Article, Prediabetic State, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Diabetes mellitus, Weight Loss, medicine, Goal achievement, Humans, 030212 general & internal medicine, Session (computer science), Aged, Community based, Attendance, Middle Aged, medicine.disease, Program intervention, United States, Diabetes Mellitus, Type 2, Female, medicine.symptom, Psychology, Goals
Abstract: Purpose The purpose of this study was to examine how maintenance session attendance and 6-month weight loss (WL) goal achievement impacted 12-month 5% WL success in older adults participating in a community-based Diabetes Prevention Program (DPP) lifestyle intervention. Methods Data were combined from 2 community trials that delivered the 12-month DPP-based Group Lifestyle Balance (GLB) to overweight/obese adults (mean age = 62 years, 76% women) with prediabetes and/or metabolic syndrome. Included participants (n = 238) attended ≥4 core sessions (months 0-6) and had complete data on maintenance attendance (≥4 of 6 sessions during months 7-12) and 6- and 12-month WL (5% WL goal, yes/no). Multivariate logistic regression was used to estimate the odds of 12-month 5% WL associated with maintenance attendance and 6-month WL. Associations between age (Medicare-eligible ≥65 vs Results Both attending ≥4 maintenance sessions and meeting the 6-month 5% WL goal increased the odds of meeting the 12-month 5% WL goal. For those not meeting the 6-month WL goal, maintenance session attendance did not improve odds of 12-month WL success. Medicare-eligible adults ≥65 years were more likely to meet the 12-month WL goal (odds ratio = 3.03, 95% CI, 1.58-5.81) versus Conclusions The results of this study provide important information regarding participant attendance and WL for providers offering DPP-based lifestyle intervention programs across the country who are seeking Medicare reimbursement. Understanding Medicare reimbursement-defined success will allow these providers to focus on and develop strategies to enhance program effectiveness and sustainability.
Published: 2021

42. 517-P: Cardiometabolic Benefits in Older Adults with Metabolic Syndrome after Diabetes Prevention Program (DPP)-Based Lifestyle Intervention

Author: Harrison J. Stern, Tina Costacou, Trevor J. Orchard, Elizabeth M. Venditti, and Rachel G. Miller
Subjects: medicine.medical_specialty, Calorie, Heart disease, Strength training, business.industry, Endocrinology, Diabetes and Metabolism, medicine.disease, Blood pressure, Weight loss, Internal medicine, Diabetes mellitus, Lifestyle intervention, Internal Medicine, medicine, medicine.symptom, Metabolic syndrome, business
Abstract: Nearly 50% of US adults >60 years have metabolic syndrome (MetS), which is linked to heart disease and diabetes. We evaluated if changes in cardiometabolic measures during a behavioral weight loss intervention for older adults differed by baseline MetS status (+ vs. -). The Pitt Retiree Study (PRS) was a 1-year lifestyle intervention trial adapted from DPP for adults 65+ years at high cardiometabolic risk. Participants attended 12 in-person group sessions, then were randomized to a monthly follow-up mode (phone or newsletter). Goals included 7% weight loss by 4 months via reduced calorie/fat intake, increased lean protein, and aerobic/strength training. Analyses include women only as 77% of PRS was female and sex differences in lipid metabolism exist. Participants (n=238) were mean (SD) age 71.1 (4.2), BMI 33.8 (5.4), and 67% had MetS at baseline. Regression models were used to compare change in cardiometabolic measures at 12 months in -MetS vs. +MetS (Table). Mean triglycerides (TG) decreased more in +MetS than -MetS while changes in other cardiometabolic measures did not differ between groups. -MetS had normal mean TG at baseline with little scope to improve, while +MetS had controlled blood pressure (BP) and LDL due to greater use of BP and lipid-lowering drugs. Nevertheless, both groups showed favorable cardiometabolic changes following lifestyle intervention. Disclosure H. J. Stern: None. R. G. Miller: None. T. J. Orchard: None. T. Costacou: None. E. M. Venditti: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R18DK096405)
Published: 2021
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43. 516-P: Objective and Subjective Physical and Mental Health Benefits in Older Adults with Cardiometabolic Risk after Diabetes Prevention Program (DPP)-Based Lifestyle Intervention

Author: Harrison J. Stern, Rachel P. Kolko Conlon, Michele D. Levine, Rachel G. Miller, Marsha D. Marcus, and Elizabeth M. Venditti
Subjects: medicine.medical_specialty, Strength training, business.industry, Endocrinology, Diabetes and Metabolism, Center for Epidemiologic Studies Depression Scale, medicine.disease, Mood, Quality of life, Diabetes mellitus, Weight management, Internal Medicine, medicine, Physical therapy, Aerobic exercise, Prediabetes, business
Abstract: Physical function, health-related quality of life (HRQoL), and depressive symptoms are key outcomes for older adults (≥65y) enrolled in behavioral weight management, but less is known about relationships among these variables. We evaluated associations between changes in these measures after a 1-year DPP-based lifestyle program. Participants (N=322) were M±SD age 71.2y±4.3, BMI 33.8±5.1, 77% women, 13% Black, averaged 4 chronic conditions, and 31% had prediabetes. Most took blood pressure (67%) and lipid (52%) medications. Participants attended 12 in-person weekly groups, then were randomized to continued monthly contact by phone or newsletter, losing 7.4% (CI) (-8.9, -5.9) and 6.1% (-8.6, -3.6) of weight at 1 year, respectively. Goals included reducing calorie/fat intake, increasing lean protein, ≥150 minutes aerobic activity/week, and strength training. Physical function was measured via Short Physical Performance Battery (SPPB) gait speed, chair rise, and balance tests, perceived HRQoL via SF-12 Physical and Mental Component Summary (PCS and MCS), and mood via Center for Epidemiologic Studies Depression Scale (CES-D) at pre- and post-intervention. Associations between baseline-12 month changes in SPPB, HRQoL and CES-D were estimated in mixed-effect models. SPPB improved by 0.3±1.4 (p=0.001) in phone and 0.3±1.7 (p=0.02) in newsletter. Increased SPPB was associated with improved PCS (β=1.18, SE=0.20, p Disclosure H. J. Stern: None. R. G. Miller: None. R. P. K. Conlon: None. M. D. Levine: None. M. D. Marcus: Advisory Panel; Self; Weight Watchers International, Inc. E. M. Venditti: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R18DK096405)
Published: 2021
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44. 1058-P: The 2018 World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) Score and Diabetes Risk in the Diabetes Prevention Program Outcomes Study (DPPOS)

Author: Catherine Kim, Elizabeth M. Venditti, Jill Reedy, Marissa Shams-White, Karla A. Temple, Ashley H. Tjaden, Sarah Bassiouni, Xavier Pi-Sunyer, Brandy M. Heckman-Stoddard, and Sharon L. Edelstein
Subjects: medicine.medical_specialty, Cancer prevention, Diabetes risk, business.industry, Endocrinology, Diabetes and Metabolism, Hazard ratio, medicine.disease, Metformin, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Marital status, Prediabetes, Family history, business, medicine.drug
Abstract: Lifestyle changes may reduce the burdens of diabetes and cancer. We examined how changes in the 2018 WCRF/AICR Score, reflecting key cancer prevention recommendations, are associated with diabetes risk. The Diabetes Prevention Program (DPP) randomized adults with prediabetes to a lifestyle intervention (ILS), metformin (MET), or placebo (PLB) for a mean of 3.2 years, with follow-up in DPPOS for 11 years. The Score includes 7 components: weight, physical activity, plant-based diet, red/processed meat, sugar-sweetened drinks, fast foods, and alcohol (0-7 points, with 7 as the best total score). Scores were estimated at years 0, 1, 5, 6, 9, and 15 for participants with complete baseline data (N = 3,147). Covariates included sex, age, race/ethnicity, marital status, education, family history of diabetes, hormone therapy (females), and energy intake. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) stratified by treatment group estimated the association of Score changes with diabetes risk in DPP and DPPOS within and between groups. There were significant Score improvements within all groups over 15 years (p < 0.001); the differences between groups were only significant after 1 year (p < 0.001; 15 years: p = 0.137). For every 1-unit improvement in Score during DPP, there was a 29% and 16% lower diabetes risk in ILS (95% CI: 0.58 - 0.88) and PLB (95% CI: 0.72 - 0.99), respectively, and no significant association in MET. The time-dependent Score improvements in ILS and PLB were significantly associated with lower diabetes risk through year 15 (ILS HR: 0.86, 95% CI 0.77 - 0.96; PLB HR: 0.85, 95% CI 0.76 - 0.95). Changes in weight, physical activity, and plant-based diet appeared to be drivers of the Score’s effect. Findings suggest that Score improvements are associated with a long-term, lower risk for diabetes among adults with prediabetes. Future research can explore how this risk reduction impacts cancer risk. Disclosure M. M. M. Shams-white: None. B. M. Heckman-stoddard: None. D. Research group: None. A. H. Tjaden: None. S. Edelstein: None. S. Bassiouni: None. C. Kim: None. X. Pi-sunyer: None. K. A. Temple: None. E. M. Venditti: None. J. Reedy: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (U01DK048489)
Published: 2021
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45. Abstract P185: Paradoxical Outcomes Among Group Lifestyle Balance Participants In Real-world Clinical Practice

Author: Sylvia Sudat, Qiwen Huang, Kristen M.J. Azar, Elizabeth M. Venditti, Robert J. Romanelli, and Alice R. Pressman
Subjects: Clinical Practice, Gerontology, business.industry, Physiology (medical), Diabetes mellitus, Lifestyle intervention, Health services research, Medicine, Cardiology and Cardiovascular Medicine, Diabetes type ii, business, medicine.disease, Balance (ability)
Abstract: Introduction: The CDC established the National Diabetes Prevention Program (NDPP) initiative in 2010, leading to implementation of numerous group-based lifestyle interventions, such as the 12-month Group Lifestyle Balance (GLB) program, in community and clinical settings. Heterogeneity in weight outcomes is common. While evidence suggests that session attendance is associated with greater weight loss, some participants do not achieve weight loss even with high session attendance. Conversely, some may achieve clinically significant weight loss (≥5%) with lower attendance. In this study, we sought to identify and characterize such paradoxical interventional outcomes. (i.e., high session attendance and Hypothesis: No a priori hypotheses. Methods: We conducted a longitudinal descriptive analysis of overweight/obese GLB participants using electronic health record data from an integrated healthcare delivery system in Northern California (2010-2017). We focused on the 12-week intensive core phase of the curriculum because prior studies show that weight loss outcomes achieved during this period are highly correlated with long-term weight loss. We categorized patients into 4 mutually exclusive groups by session attendance ( Results: Among 1,818 evaluable participants, we identified 870 (47.9%) with paradoxical outcomes. Of these, 104 (12.0%) achieved ≥5% weight loss with Conclusions: Nearly half of all GLB participants in this integrated health system had paradoxical outcomes, with more than 40% classified as paradoxical non-responders. These results suggest that session attendance may not be as sensitive a predictor of weight outcomes as previously thought, and other approaches are needed to understand the complex factors influencing goal attainment in behavioral lifestyle programs.
Published: 2021
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46. Preferences for Technology-Mediated Behavioral Lifestyle Interventions With Different Levels of Coach and Peer Support Among Latino Men: Comparative Study Within One Arm of a Randomized Controlled Trial

Author: Lisa G Rosas, Nan Lv, Lan Xiao, Kristen MJ Azar, Steven P Hooker, Elizabeth M Venditti, Megan A Lewis, Patricia Zavella, and Jun Ma
Subjects: Medicine (miscellaneous), Health Informatics, Computer Science Applications
Abstract: Background Although Latino men have the highest prevalence (45%) of obesity among all men in the United States, traditional weight loss interventions have not effectively engaged this hard-to-reach and diverse group. Offering choices among technology-mediated weight loss interventions may offer advantages. Objective The aim of this study is to examine Latino men’s preferences among 3 weight loss intervention options. We also examined whether attendance in group sessions (videoconference and in person) and weight loss differed according to intervention choice. Methods Latino men (n=200; mean age 47.3, SD 11.8 years) participated in a comparative effectiveness trial based on primary care and were randomized to receive the 1-year HOMBRE (Hombres con Opciones para Mejorar su Bienestar para Reducir Enfermedades Crónicas; English translation: Men With Options to Improve Their Well-being and Reduce Chronic Disease) intervention. HOMBRE is a weight loss intervention that offers 3 delivery options. During an orientation session, a trained bilingual coach helped men select 1 of the 3 intervention options that differed in coach, peer support, and available language. We used canonical discriminant analysis to assess multivariate associations of demographic, clinical, employment, cultural, and technology use and access factors with men’s intervention choices. We used generalized linear models to estimate weight loss at 6, 12, and 18 months for men in each intervention option. Results Among Latino men, 28% (56/200) chose videoconference groups, 31% (62/200) chose web-based videos, and 41% (82/200) chose in-person groups. The canonical discriminant analysis identified 1 orthogonal dimension that distinguished between men who chose an in-person group and men who chose web-based videos. Men who were older, spoke Spanish, and did not use a computer frequently had a higher probability of choosing in-person groups versus web-based videos. For men who selected a group delivery option, 86.9% (107/123) attended ≥25% of the sessions, 83.7% (103/123) attended ≥50% of the sessions, and 73.2% (90/123) attended ≥75% of the sessions, with no differences by type of group (videoconference or in person). Men who chose videoconference and in-person group sessions lost significantly more weight at 6 months (both P Conclusions There were significant differences according to demographic, employment, cultural, and technology use factors between men who chose 1 of the 3 intervention options. Men who chose one of the group-based options (videoconference or in person) lost significantly more weight than those who chose web-based videos. Providing options that accommodate the diversity of Latino men’s preferences is important for increasing engagement in behavioral interventions. Trial Registration ClinicalTrials.gov NCT03092960; https://clinicaltrials.gov/ct2/show/NCT03092960
Published: 2021

47. Preferences for Technology-Mediated Behavioral Lifestyle Interventions With Different Levels of Coach and Peer Support Among Latino Men: Comparative Study Within One Arm of a Randomized Controlled Trial (Preprint)

Author: Lisa G Rosas, Nan Lv, Lan Xiao, Kristen MJ Azar, Steven P Hooker, Elizabeth M Venditti, Megan A Lewis, Patricia Zavella, and Jun Ma
Abstract: BACKGROUND Although Latino men have the highest prevalence (45%) of obesity among all men in the United States, traditional weight loss interventions have not effectively engaged this hard-to-reach and diverse group. Offering choices among technology-mediated weight loss interventions may offer advantages. OBJECTIVE The aim of this study is to examine Latino men’s preferences among 3 weight loss intervention options. We also examined whether attendance in group sessions (videoconference and in person) and weight loss differed according to intervention choice. METHODS Latino men (n=200; mean age 47.3, SD 11.8 years) participated in a comparative effectiveness trial based on primary care and were randomized to receive the 1-year HOMBRE (Hombres con Opciones para Mejorar su Bienestar para Reducir Enfermedades Crónicas; English translation: Men With Options to Improve Their Well-being and Reduce Chronic Disease) intervention. HOMBRE is a weight loss intervention that offers 3 delivery options. During an orientation session, a trained bilingual coach helped men select 1 of the 3 intervention options that differed in coach, peer support, and available language. We used canonical discriminant analysis to assess multivariate associations of demographic, clinical, employment, cultural, and technology use and access factors with men’s intervention choices. We used generalized linear models to estimate weight loss at 6, 12, and 18 months for men in each intervention option. RESULTS Among Latino men, 28% (56/200) chose videoconference groups, 31% (62/200) chose web-based videos, and 41% (82/200) chose in-person groups. The canonical discriminant analysis identified 1 orthogonal dimension that distinguished between men who chose an in-person group and men who chose web-based videos. Men who were older, spoke Spanish, and did not use a computer frequently had a higher probability of choosing in-person groups versus web-based videos. For men who selected a group delivery option, 86.9% (107/123) attended ≥25% of the sessions, 83.7% (103/123) attended ≥50% of the sessions, and 73.2% (90/123) attended ≥75% of the sessions, with no differences by type of group (videoconference or in person). Men who chose videoconference and in-person group sessions lost significantly more weight at 6 months (both PP=.02 and P=.04, respectively) than those who chose web-based videos. Men who chose in-person group sessions also lost significantly more weight at 12 months (P=.008) than those who chose web-based videos. CONCLUSIONS There were significant differences according to demographic, employment, cultural, and technology use factors between men who chose 1 of the 3 intervention options. Men who chose one of the group-based options (videoconference or in person) lost significantly more weight than those who chose web-based videos. Providing options that accommodate the diversity of Latino men’s preferences is important for increasing engagement in behavioral interventions. CLINICALTRIAL ClinicalTrials.gov NCT03092960; https://clinicaltrials.gov/ct2/show/NCT03092960
Published: 2021
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48. Profiles of Accelerometry-Derived Physical Activity are Related to Perceived Physical Fatigability in Older Adults

Author: Jaroslaw Harezlak, Elizabeth M. Venditti, Yujia Susanna Qiao, Robert M. Boudreau, Nancy W. Glynn, Kyle D. Moored, Jessica L Graves, Eric J. Shiroma, and Robert T. Krafty
Subjects: medicine.medical_specialty, Rest, Physical activity, lcsh:Chemical technology, Biochemistry, Article, Analytical Chemistry, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Accelerometry, medicine, Humans, lcsh:TP1-1185, 030212 general & internal medicine, Electrical and Electronic Engineering, Instrumentation, Exercise, neoplasms, older adults, Aged, business.industry, rest–activity rhythm, Atomic and Molecular Physics, and Optics, Rest activity rhythm, Cardiology, fatigue, business, Body mass index, 030217 neurology & neurosurgery
Abstract: Physical activity (PA) is associated with greater fatigability in older adults, little is known about magnitude, shape, timing and variability of the entire 24-h rest–activity rhythm (RAR) associated with fatigability. We identified which features of the 24-h RAR pattern were independently and jointly associated with greater perceived physical fatigability (Pittsburgh Fatigability Scale, PFS, 0–50) in older adults (n = 181, 71.3 ± 6.7 years). RARs were characterized using anti-logistic extended cosine models and 4-h intervals of PA means and standard deviations across days. A K-means clustering algorithm approach identified four profiles of RAR features: “Less Active/Robust”, “Earlier Risers”, “More Active/Robust” and “Later RAR”. Quantile regression tested associations of each RAR feature/profile on median PFS adjusted for age, sex, race, body mass index and depression symptomatology. Later rise times (up mesor, β = 1.38, p = 0.01) and timing of midpoint of activity (acrophase, β = 1.29, p = 0.01) were associated with higher PFS scores. Lower PA between 4 a.m. and 8 a.m. was associated with higher PFS scores (β = −4.50, p = 0.03). “Less Active/Robust” (β = 6.14, p = 0.01) and “Later RAR” (β = 3.53, p = 0.01) patterns were associated with higher PFS scores compared to “Earlier Risers”. Greater physical fatigability in older adults was associated with dampened, more variable, and later RARs. This work can guide development of interventions aimed at modifying RARs to reduce fatigability in older adults.
Published: 2021
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49. Sex Moderates Treatment Effects of Integrated Collaborative Care for Comorbid Obesity and Depression: The RAINBOW RCT

Author: Leanne M. Williams, Jun Ma, Mark B Snowden, Corina R. Ronneberg, Olusola Ajilore, Aashutos S. Patel, Megan A. Lewis, Elizabeth M. Venditti, Nan Lv, Joshua M. Smyth, Ben S. Gerber, Lisa G. Rosas, and Lan Xiao
Subjects: Male, medicine.medical_specialty, Psychological intervention, Collaborative Care, Comorbidity, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Weight loss, Internal medicine, Weight Loss, medicine, Humans, 030212 general & internal medicine, Obesity, General Psychology, Depression (differential diagnoses), business.industry, Depression, Regular Article, medicine.disease, Psychiatry and Mental health, Affect, Mood, Female, medicine.symptom, business, Psychosocial, 030217 neurology & neurosurgery
Abstract: Background Sex influences health and related behaviors due to biological and psychosocial/socioeconomic factors. Assessing sex-specific responses to integrated treatment for comorbid obesity and depression could inform intervention targeting. Purpose To test (a) whether sex moderates the effects of integrated collaborative care on weight and depression outcomes through 24 months and (b) whether treatment response at 6 months predicts 12 and 24 month outcomes by sex. Methods Secondary data analyses on weight and depression severity (SCL-20) measured over 24 months among 409 adults with obesity and depression in the Research Aimed at Improving Both Mood and Weight trial. Results Men achieved significantly greater weight reductions in intervention versus usual care than women, whereas women achieved significantly greater percentage reductions in SCL-20 than men at both 12 and 24 months. In logistic models, at 80% specificity for correctly identifying participants not achieving clinically significant long-term outcomes, women who lost Conclusions Sex modified the integrated treatment effects for obesity and depression. Sex-specific responses at 6 months predicted clinically significant weight loss and depression outcomes through 24 months. Based on early responses, interventions may need to be tailored to address sex-specific barriers and facilitators to achieving healthy weight and depression outcomes at later time points. Clinical Trial Registration NCT02246413 (https://clinicaltrials.gov/ct2/show/NCT02246413).
Published: 2021

50. Correction: Clinical course of Coronavirus Disease-19 in patients with haematological malignancies is characterized by a longer time to respiratory deterioration compared to non-haematological ones: results from a case–control study

Author: A. Oliva, A. Curtolo, L. Volpicelli, F. Cancelli, C. Borrazzo, F. Cogliati Dezza, G. Marcelli, F. Gavaruzzi, S. Di Bari, P. Ricci, O. Turriziani, C. M. Mastroianni, and M. Venditti
Subjects: Microbiology (medical), Infectious Diseases, General Medicine
Published: 2022
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