1. Hospital-Wide SARS-CoV-2 seroprevalence in health care workers in a Spanish teaching hospital
- Author
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Mª Isabel Galán, María Velasco, Mª Luisa Casas, Mª José Goyanes, Gil Rodríguez-Caravaca, Juan E. Losa-García, Carmen Noguera, Virgilio Castilla, Alejandro Algora Weber, Juan Carlos Alonso Punter, María Teresa Alonso Salazar, Gregorio Bonilla Zafra, M. Mercedes Bueno Campaña, Camilo Carrión Pulido, Ana Isabel Díaz Cuasante, Aurora Fabero Jiménez, Rosa María Fariña García, María Isabel González Anglada, Carlos Guijarro Herraiz, M. Mercedes Izquierdo Patron, Susana Lorenzo Martínez, Margarita Mosquera González, Montserrat Pérez Encinas, Elia Pérez Fernández, Francisco José Pérez Vega, and Maria Esther Renilla Sánchez
- Subjects
0301 basic medicine ,Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Health Personnel ,education ,030106 microbiology ,Logistic regression ,Asymptomatic ,Infección nosocomial ,Teaching hospital ,03 medical and health sciences ,0302 clinical medicine ,Cross infection ,Seroepidemiologic Studies ,Internal medicine ,Health care ,Seroprevalencia ,medicine ,Seroprevalence ,Humans ,030212 general & internal medicine ,Hospitals, Teaching ,business.industry ,Transmission (medicine) ,SARS-CoV-2 ,COVID-19 ,Cross-Sectional Studies ,Immunoglobulin G ,Trabajador sanitario ,RNA, Viral ,Original Article ,Female ,medicine.symptom ,business - Abstract
Introduction Hospital-wide SARS-CoV-2 seroprevalence is rarely explored and can identify areas of unexpected risk. We determined the seroprevalence against SARS-CoV-2 in all health care workers (HCW) at a hospital. Methods Cross-sectional study (14-27/04/2020). We determined SARS-CoV-2 IgG by ELISA in all HCW including external workers of a teaching hospital in Madrid. They were classified by professional category, working area, and risk for SARS-CoV-2 exposure. Results Among 2919 HCW, 2590 (88,7%) were evaluated. The mean age was 43.8 years (SD 11.1), and 73.9% were females. Globally, 818 (31.6%) workers were IgG positive with no differences for age, sex or previous diseases. Of these, 48.5% did not report previous symptoms. Seropositivity was more frequent in high- (33.1%) and medium- (33.8%) than in low-risk areas (25.8%, p = 0.007), but not for hospitalization areas attending COVID-19 and non-COVID-19 patients (35.5 vs 38.3% p > 0.05). HWC with a previous SARS-CoV2 PCR-positive test were IgG seropositive in 90.8%. By multivariate logistic regression analysis seropositivity was significantly associated with being physicians (OR 2.37, CI95% 1.61–3.49), nurses (OR 1.67, CI95% 1.14–2.46), nurse assistants (OR 1.84, CI95% 1.24–2.73), HCW working at COVID-19 hospitalization areas (OR 1.71, CI95% 1.22–2.40), non-COVID-19 hospitalization areas (OR 1.88, CI95% 1.30–2.73), and at the Emergency Room (OR 1.51, CI95% 1.01–2.27). Conclusions Seroprevalence uncovered a high rate of infection previously unnoticed among HCW. Patients not suspected of having COVID-19 as well as asymptomatic HCW may be a relevant source for nosocomial SARS-CoV-2 transmission.
- Published
- 2020