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Renal cell carcinomas, which comprise the majority of primary kidney tumors, present diverse challenges in treatment planning. This case report explores the application of simultaneous partial nephrectomy and radiofrequency (RF) ablation in a patient with a solitary kidney, emphasizing the significance of specific interventions. A 52-year-old female patient who underwent radical nephrectomy presented with right flank pain and hematuria. Contrast-enhanced computed tomography revealed exophytic and calyceal system-extending lesions in the right kidney. A multidisciplinary approach involving interventional radiology and nephrology facilitated preoperative preparation. The patient underwent simultaneous partial nephrectomy and RF ablation in a single session, resulting in favorable outcomes. This meta-analysis highlighted radical nephrectomy's association with chronic kidney disease, emphasizing the need for specialized treatment approaches. Ablative treatment was associated with superior perioperative outcomes, whereas partial nephrectomy exhibited higher urological complication rates. Minimally invasive techniques are crucial, especially for solitary kidney cases and small renal tumors. Simultaneous partial nephrectomy and RF ablation are effective for managing exophytic and calyceal system-extending masses in solitary kidneys. The preservation of renal function is of paramount importance, prompting consideration of ablative treatment alongside partial nephrectomy. Despite limited evidence, ablative therapies offer a viable alternative for frail and comorbid patients, ensuring long-term oncological durability and superior preservation of renal function. Keywords:Ablation, partial nephrectomy, radical nephrectomy, radiofrequency ablation, renal cell carcinoma, renal tumor, tumor: [ABSTRACT FROM AUTHOR]

Objective: Some prognostic models have been described for localized and metastatic renal cell carcinoma (RCC). The European Association of Urology guidelines on RCC recommend using these models. However, there is no model for T1 and T2. The study evaluated the risk factors for recurrence in T1 and T2 RCC. Materials and Methods: Data of 4823 renal tumor patients from the Renal Tumor Database of the Association of Urooncology in Turkey were evaluated. Of 4823 patients, 1845 RCC patients with pathological T1 or T2 were included in this study. The patients were divided into two groups according to the recurrence status. Anatomical, histological, and clinical prognostic factors were statistically compared between the groups. Afterwards, multivariate analysis was performed for the variables that were found to be statistically significant. Results: The mean follow-up time was 30 (4-180) months. Of 1845 RCC patients, 117 (6.3%) had recurrence. Univariate analysis revealed statistically significant differences between age, preoperative hemoglobin, albumin, neutrophil, alkaline phosphates, platelet and calcium values, histological subtype, Fuhrman grade, surgical technique (radical or partial), and pathological stage in the groups. However, in multivariate analysis, only pathological stage was found to be a risk factor for recurrence (2.17 95%, 1.25-3.77). Conclusions: The results of our study show that it is difficult to design a prognostic model for the recurrence of pT1 and pT2 RCC. We suggest that patients with a higher tumor diameter should be followed up more frequently. [ABSTRACT FROM AUTHOR]

Objective: The incidence of advanced prostate cancer increases in proportion to new treatment options and prolonged life expectancy. Especially in advanced disease, prostate cancer is a progressive disease that can cause obstructive uropathy. This study investigated the relationship between the characteristics of advanced prostate cancer and obstructive uropathy. Materials and Methods: This study retrospectively evaluated the data of prostate adenocarcinoma patients admitted to the Urology Clinic of Manisa Celal Bayar University Hospital between 2017 and 2021. Of them, 48 were advanced prostate cancer patients, and they were all included. All patients in the study received hormonal therapy along with chemotherapy for prostate cancer treatment. The relationship between hydronephrosis and patient age, creatinine and prostatespecific antigen (PSA) values, urinary tract infections, prostate volume, pathological features of cancer, and castration resistance was evaluated. Results: Parameters that we found to be associated with obstructive uropathy (OU) are as follows: high creatinine level at the time of diagnosis of cancer (p<0.001), increase in creatinine at follow-up (p=0.001), urinary infection at the time of diagnosis of cancer (p=0.002) and at follow-up (p=0.003), development of castration resistance during treatment (p=0.038) and high PSA values at the time of diagnosis of prostate cancer (p=0.011). Conclusion: Renal functions should be observed very carefully in advanced prostate cancer patients who develop or are at risk of developing OU. High PSA values and/or castration resistance should be approached carefully in terms of the patients prognosis. It should not be forgotten that their significant relationship with OU has been demonstrated. [ABSTRACT FROM AUTHOR]

Objective: This report examined the approaches to low-risk patients using the data from the Urologic Cancer Database - Prostate, Urooncology Association. Materials and Methods: In this study, there were 920 patients with low-risk prostate cancer according to the current guidelines of the European Urology Association. Patient data were obtained from the Urological Cancer Database - Prostate, the Turkish Urooncology Association (UroCaD-P) from records of the years 1995-2021. Ethics committee approval was obtained for this study to publish in the form of a database report. Results: Our study was conducted with 920 patients with low-risk prostate cancer. Therefore, at the time of diagnosis, all patients in the study were ISUP 1, had a prostate specific antigen (PSA) level lower than 10 ng/mL, and clinically T1-T2a. Surgical treatment was used in 750 (81.5%) of the patients. At the time patients were retrieved from the database for the study, 140 patients (15.2%) were in the active surveillance (AS) process. Thirty patients (3.2%) in the study received their local treatment as radiotherapy (RT). The mean age value at cancer detection in the study was 61.9. The mean ages of the patients who were under AS and who underwent radical prostatectomy (RP) were 61.3 and 61.7 years, respectively. In the RT group, the mean age was 66.7 years. The mean PSA value of the whole group was 5.81 ng/mL. While it was 5.94 in AS patients, it was calculated as 5.89 in patients who underwent radical surgery. The mean PSA value of the RT group was 5.40. The pathological upgrade was detected in 225 patients (30%) after surgery. Surgical margin positivity was in 160 of the patients (21.3%) who underwent surgery. In addition, 100 patients (13.3%) had extracapsular disease. The seminal vesicle invasion was detected in 25 patients (3.3%) after surgery. Conclusion: We predict that the incidence of low-risk prostate cancer will increase over time due to the aging of the population, the use of PSA, advances in imaging modalities, and increasing biopsy success rates. Therefore, the importance of the existence of multicentric databases containing this patient group is undeniable. More studies are needed with these databases, including both patient demographics and treatment outcomes. Hopefully, this database report will be an important step in this direction. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate the effect of postoperative early mobilization in patients who underwent radical cystectomy (RC) and ileal conduit in terms of the healing process and quality of life (QoL). Materials and Methods: This multicenter prospective randomized controlled study included 40 patients who were randomly divided into two groups. The intervention group was mobilized within the first 16 h postoperatively following the mobilization procedure, which was determined according to the literature. Data were collected using the case report form, hospital anxiety and depression scale, and 36-Item Short Form Survey (SF-36) QoL scale. Results: Postoperative hospitalization, narcotic analgesic administration duration, first oral food intake, flatus, defecation, and nasogastric tube termination time were shorter in the intervention group. Additionally, blood glucose and pulse values were higher in the control group after mobilization. SF-36 physical function, physical role difficulty, and general perception of health subscales were higher in the intervention group at the postoperative first and third months (p<0.05). Conclusion: Early mobilization positively contributed to the healing process and improved the QoL in patients who underwent RC and ileal conduit surgery. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to investigate pathological lymph node involvement in selected patients and the relationship of prostate-specific antigen (PSA) progression-free survival rates between patients with and without lymph node involvement on preoperative conventional radiologic imaging. Limited data is available about local treatment outcomes in patients with prostate cancer (PCa) having clinical lymph node involvement. Materials and Methods: Using the national PCa database, patients who underwent radical prostatectomy (RP) and pelvic lymph node dissection between 2001 and 2019, with pathologic lymph node involvement, were included in the study. Patients were divided into two groups as those with and without clinical lymph node involvement by preoperative imaging. Results: A total of 213 patients were included in the final analysis, wherein 164 are with and 49 are without lymph node involvement. After the mean follow-up periods of 33.9 months, a significant difference was not found between the two groups in terms of recurrence, adjuvant treatment necessity, and final status. The multivariate analysis for 5-year PSA recurrence-free survival revealed that surgical margin positivity was the only significant factor (p=0.016, hazard ratio: 2.67, confidence interval: 1.19-5.98). Conclusion: Our results revealed that preoperative clinical lymph node status did not affect the 5-year PSA recurrence-free survival in pathologic lymph node involvement of patients treated with RP and pelvic lymph node dissection. Therefore, RP stands as an effective treatment option in selected patients with PCa having clinical lymph node involvement. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the effect of risk factors and selected surgical methods on operative and oncological results of patients undergoing radical prostatectomy (RP) with high‐risk prostate cancer (HRPC). Methods: Retrospective analysis of patients who underwent RP for HRPC from 13 urology centres between 1990 and 2019 was performed. Groups were created according to the risk factors of D'Amico classification. Patients with one risk factor were included in group 1 where group 2 consisted of patients with two or three risk factors. Results: A total of 1519 patients were included in this study and 1073 (70.6%) patients were assigned to group 1 and 446 (29.4%) patients to group 2. Overall (biochemical and/or clinical and/or radiological) progression rate was 12.4% in group 1 and 26.5% in group 2 (P =.001). Surgical procedure was open RP in 844 (55.6%) patients and minimally invasive RP in 675 (44.4%) patients (laparoscopic and robot‐assisted RP in 230 (15.1%) and 445 (29.3%) patients, respectively). Progression rates were similar in different types of operations (P =.22). Progression rate was not significantly different in patients who either underwent pelvic lymph node dissection (PLND) or not in each respective group. Conclusion: RP alone is an effective treatment in the majority of patients with HRPC and PLND did not affect the progression rates after RP. According to the number of pre‐operative high‐risk features, as the number of risk factors increases, there is a need for additional treatment. [ABSTRACT FROM AUTHOR]

Liposarcoma is a tumour originating from the mesoderm, which captures nearly twenty percent of all sarcomas. It first described by Lesauvage in 1845. Seventy percent of cases are extremity and retroperitoneum masses. Paratesticular liposarcoma is a rare entity. For treatment, a tumour-free margin radical orchiectomy with wide local excision and high ligation of the spermatic cord should be performed. If needed radiotherapy should be applied. An eighty-six-year-old male patient with paratesticular liposarcoma is reported in this article. [ABSTRACT FROM AUTHOR]

Objective: To investigate the prognostic role of positive surgical margin (PSM) features in addition to well-defined risk factors in predicting biochemical recurrence (BCR) after radical prostatectomy. Materials and Methods: This study used the prostate cancer database from the Urooncology Association in Turkey. Clinical, surgical, pathological and follow-up data were recorded from the database. PSM features, including number, location, linear length and Gleason grade (GG) were also recorded. Kaplan-Meier survival analyses were performed to assess differences in BCR-free survival (BCR-FS). In order to identify prognostic factors affecting BCR-FS, univariate and multivariate Cox regression analyses were performed. Results: The study included 984 patients who met the eligibility criteria. The median follow-up time was 29 (minimum: 6, maximum: 210) months, and BCR was detected in 178 (18.1%) patients. BCR-FS was found to be significantly lower in patients with higher total prostate-specific antigen, higher International Society of Urological Pathology (ISUP) grade, extraprostatic extension (EPE), seminal vesicle invasion, lymphovascular invasion, lymph node involvement, PSM and GG at PSM (PSMGG) =4 (log-rank p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001 and p=0.005). ISUP grade, EPE and PSM were identified as independent prognostic factors in predicting BCR-FS [Hazard ratio (HR): 1.89, p=0.035 and HR: 4.65, p<0.001, HR: 1.82, p=0.030, HR: 1.77, p=0.042, respectively]. Unlike the univariate analysis, in multivariate analysis, PSMGG did not prove to be an independent prognostic factor in predicting BCR-FS. Conclusion: PSM GG =4 was found to be significantly associated with shorter BCR-FS. There is a need for large, randomised prospective studies to clarify the role of PSMGG to be used in nomograms as an independent predictor to determine patients who would benefit from adjuvant radiation therapy. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study is to investigate the relevance of the Epstein criteria for the 12-core transrectal prostate biopsy (TRUS-Bx) scheme with the evaluation of clinicopathologic data recorded in the Urologic Cancer Database - Prostate (UroCaD-P), Urooncology Association, Turkey (UOAT). Materials and Methods: Patients with detailed pathological 12-core TRUS-Bx data for each biopsy core and who underwent RP due to PCa were included in this study. A total of 1167 patients from seven different centres were analysed. TRUS-Bx pathological findings were separately evaluated in the areas matching the sextant biopsy (6-core paramedian-lateral) scheme and in all 12-core biopsy areas (12-core biopsy scheme). Overall detection rates of PCa and ratios of clinically significant (sPCa) and insignificant PCa (insPCa) after RP were defined and compared between the biopsy schemes. Biopsy findings, according to the Epstein criteria, were also compared between the two schemes. A model for each biopsy scheme was created, including the Epstein criteria and additional biopsy findings using logistic regression analysis to predict clinically sPCa after RP. Results: There was a high correlation for the prediction of clinically insPCa between the two biopsy schemes in the same population. However, 7.3% of PCa could not be diagnosed in the 6-core TRUS-Bx scheme. Also, 69.4% of these had clinically sPCa according to the Epstein criteria in 12-core TRUS-Bx scheme and 51.8% of these were clinically sPCa after RP. The presence of perineural invasion (PNI) in 12-core biopsy was also significant regarding predicting sPCa (p<0.001). Conclusion: The Epstein criteria in 12-core prostate biopsy provide a better prediction of clinically sPCa than the 6-core biopsy scheme. Biopsy PNI findings appeared to improve the effectiveness of 12-core prostate biopsy, in addition to the Epstein criteria. [ABSTRACT FROM AUTHOR]

In a 55-year-old woman patient with a body mass index of 27 kg/m2, a giant staghorn kidney stone (10 × 6.4 × 8 cm) was detected in the right kidney on computed tomography, then the patient was treated with a single-session percutaneous nephrolithotomy, and there were no complications afterwards. [ABSTRACT FROM AUTHOR]