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2. Understanding the barriers to prostate cancer population-based early detection programs: The PRAISE-U BEST survey

Author

Beyer, K., primary, Leenen, R., additional, Venderbos, L.D.F., additional, Helleman, J., additional, Denijs, F., additional, Gomez Rivas, J., additional, Vasilyeva, V., additional, Briers, E., additional, Chloupkova, R., additional, Májek, O., additional, Frese, T., additional, Vilaseca, J., additional, Vinker, S., additional, Vynckier, P., additional, Annemans, L., additional, Basu, P., additional, Chandran, A., additional, Van Den Bergh, R.C.N., additional, Collen, S., additional, Van Poppel, H., additional, and Roobol, M.J., additional

Published
2024
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3. Why is there a need to re-think prostate cancer early detection?

Author

Beyer, K., primary, Leenen, R., additional, Venderbos, L.D.F., additional, Denijs, F., additional, Helleman, J., additional, Chloupkova, R., additional, Májek, O., additional, Briers, E., additional, Vasilyeva, V., additional, Gomez Rivas, J., additional, Annemans, L., additional, Vynckier, P., additional, Basu, P., additional, Chandran, A., additional, Van Den Bergh, R.C.N., additional, Collen, S., additional, Stenzl, A., additional, Van Poppel, H., additional, and Roobol, M.J., additional

Published
2024
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8. The time is now: Achieving FH paediatric screening across Europe - The Prague Declaration

Author

Bedlington, N, Abifadel, M, Beger, B, Bourbon, M, Bueno, H, Ceska, R, Cillíková, K, Cimická, Z, Daccord, M, de Beaufort, C, Dharmayat, KI, Ference, BA, Freiberger, T, Geanta, M, Gidding, SS, Groselj, U, Halle, M, Johnson, N, Novakovic, T, Májek, O, Pallidis, A, Peretti, N, Pinto, FJ, Ray, KK, Rees, B, Reeve, J, Reiner, Z, Santos, RD, Schunkert, H, Sikonja, J, Sokolovic, M, Tokgözoglu, L, Vrablík, M, Wiegman, A, Gutiérrez-Ibarluzea, I, Bedlington, N, Abifadel, M, Beger, B, Bourbon, M, Bueno, H, Ceska, R, Cillíková, K, Cimická, Z, Daccord, M, de Beaufort, C, Dharmayat, KI, Ference, BA, Freiberger, T, Geanta, M, Gidding, SS, Groselj, U, Halle, M, Johnson, N, Novakovic, T, Májek, O, Pallidis, A, Peretti, N, Pinto, FJ, Ray, KK, Rees, B, Reeve, J, Reiner, Z, Santos, RD, Schunkert, H, Sikonja, J, Sokolovic, M, Tokgözoglu, L, Vrablík, M, Wiegman, A, and Gutiérrez-Ibarluzea, I

Abstract

Familial hypercholesterolaemia (FH) is the most common inherited metabolic disorder characterized by high cholesterol and if left untreated leads to premature cardiovascular disease, such as heart attacks. Treatment that begins early in life, particularly in childhood, is highly efficacious in preventing cardiovascular disease and cost-effective, thus early detection of FH is crucial. However, in Europe, less than 10% of people living with FH are diagnosed and even less receive life-saving treatment. The Prague Declaration is a call to action for national and European Union policymakers and decision-makers and a result of the Czech EU Presidency meeting on FH Paediatric Screening (early detection of inherited high cholesterol) at the Czech Senate in Prague on 6th September 2022. It builds on a considerable body of evidence which was discussed at the Technical Meeting under the auspices of the Slovenian EU Presidency in October 2021. The Prague meeting addressed the outstanding barriers to the systematic implementation of FH paediatric screening across Europe. In this article, we present the key points from the Prague meeting and concrete actions needed to move forward.

Published
2022

11. Program časného záchytu karcinomu plic.

Author

Skřičková, J., Hejduk, K., Májek, O., Vašáková, M. Koziar, and Peterová-Čierná, I.

Abstract

Copyright of Studia Pneumologica et Phthiseologica is the property of TRIOS, spol. sr.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

14. Projekt „Časný záchyt chronické obstrukční plicní nemoci v rizikové populaci" -- jaké jsou průběžné výsledky?

Author

Brat, K., Kouřil, J., Hejduk, K., Král, N., Skřičková, J., Kos, S., Peterová, I. Čierná, Ngo, O., Mandelová, L., Májek, O., and Koblížek, V.

Abstract

Copyright of Studia Pneumologica et Phthiseologica is the property of TRIOS, spol. sr.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

16. Mammographic screening programmes in Europe: organization, coverage and participation

Author

Giordano L, von Karsa L, Tomatis M, Majek O, de Wolf C, Lancucki L, Hofvind S, Nyström L, Segnan N, Ponti A, Eunice Working Group, Van Hal G, Martens P, Májek O, Danes J, von Euler-Chelpin M, Aasmaa A, Anttila A, Becker N, Péntek Z, Budai A, Mádai S, Fitzpatrick P, Mooney T, Zappa M, Ventura L, Scharpantgen A, Seroczynski P, Morais A, Rodrigues V, Bento MJ, Gomes de Carvalho J, Natal C, Prieto M, Sánchez-Contador Escudero C, Zubizarreta Alberti R, Fernández Llanes SB, Ascunce N, Ederra Sanza M, Sarriugarte Irigoien G, Salas Trejo D, Ibáñez Cabanell J, Wiege M, Ohlsson G, Törnberg S, Korzeniewska M, Fracheboud J, Patnick J J, Ducarroz S, and Suonio E

Abstract

Objectives To summarize participation and coverage rates in population mammographic screening programmes for breast cancer in Europe. Methods We used the European Network for Information on Cancer (EUNICE), a web-based data warehouse (EUNICE Breast Cancer Screening Monitoring, EBCSM) for breast cancer screening, to obtain information on programme characteristics, coverage and participation from its initial application in 10 national and 16 regional programmes in 18 European countries. Results The total population targeted by the screening programme services covered in the report comprised 26.9 million women predominantly aged 50-69. Most of the collected data relates to 2005, 2006 and/or 2007. The average participation rate across all programmes was 53.4% (range 19.4-88.9% of personally invited); or 66.4% excluding Poland, a large programme that initiated personal invitations in 2007. Thirteen of the 26 programmes achieved the European Union benchmark of acceptable participation (>70%), nine achieved the desirable level (>75%). Despite considerable invitation coverage across all programmes (79.3%, range 50.9-115.2%) only 48.2% (range 28.4-92.1%) of the target population were actually screened. The overall invitation and examination coverage excluding Poland was 70.9% and 50.3%, respectively. Conclusions The results demonstrate the feasibility of European-wide screening monitoring using the EBCSM data warehouse, although further efforts to refine the system and to harmonize standards and data collection practices will be required, to fully integrate all European countries. The more than threefold difference in the examination coverage should be taken into account in the evaluation of service screening programmes.

Published
2012

17. False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes

Author

Hofvind S, Ponti A, Patnick J, Ascunce N, Njor S, Broeders M, Giordano L, Frigerio A, Törnberg S, EUNICE Project and Euroscreen Working Groups, Van Hal G, Martens P, Májek O, Danes J, von Euler-Chelpin M, Aasmaa A, Anttila A, Becker N, Péntek Z, Budai A, Mádai S, Fitzpatrick P, Mooney T, Zappa M, Ventura L, Scharpantgen A, Seroczynski P, Morais A, Rodrigues V, Bento MJ, Gomes de Carvalho J, Natal C, Prieto M, Sánchez-Contador Escudero C, Zubizarreta Alberti R, Fernández Llanes SB, Ederra Sanza M, Sarriugarte Irigoien G, Salas Trejo D, Ibáñez Cabanell J, Wiege M, Ohlsson G, Korzeniewska M, de Wolf C, Fracheboud J, Lancucki L, Ducarroz S, and Suonio E

Abstract

Objective To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment. Methods A literature review was conducted to identify studies of the cumulative risk of a false-positive result in European screening programmes (390,000 women). We then examined aggregate data, cross-sectional information about further assessment procedures among women with positive results in 20 mammographic screening programmes from 17 countries (1.7 million initial screens, 5.9 million subsequent screens), collected by the European Network for Information on Cancer project (EUNICE). Results The estimated cumulative risk of a false-positive screening result in women aged 50-69 undergoing 10 biennial screening tests varied from 8% to 21% in the three studies examined (pooled estimate 19.7%). The cumulative risk of an invasive procedure with benign outcome ranged from 1.8% to 6.3% (pooled estimate 2.9%). The risk of undergoing surgical intervention with benign outcome was 0.9% (one study only). From the EUNICE project, the proportions of all screening examinations in the programmes resulting in needle biopsy were 2.2% and 1.1% for initial and subsequent screens, respectively, though the rates differed between countries; the corresponding rates of surgical interventions among women without breast cancer were 0.19% and 0.07%. Conclusion The specific investigative procedures following a recall should be considered when examining the cumulative risk of a false-positive screening result. Most women with a positive screening test undergo a non-invasive assessment procedure. Only a small proportion of recalled women undergo needle biopsy, and even fewer undergo surgical intervention.

Published
2012

18. International variation in management of screen-detected ductal carcinoma in situ of the breast

Author

Ponti, A. (Antonio), Lynge, E. (Elsebeth), James, T. (Ted), Májek, O. (Ondřej), Von Euler-Chelpin, M. (My), Anttila, A. (Ahti), Fitzpatrick, P. (Patricia), Mano, M.P. (Maria Piera), Kawai, M. (Masaaki), Scharpantgen, A. (A.), Fracheboud, J. (Jacques), Hofvind, S. (Solveig), Vidal, C. (Carmen), Ascunce, N. (Nieves), Salas, D. (Dolores), Bulliard, J.-L. (Jean-Luc), Segnan, N. (Nereo), Kerlikowske, K. (Karla), Taplin, S. (Stephen), Ponti, A. (Antonio), Lynge, E. (Elsebeth), James, T. (Ted), Májek, O. (Ondřej), Von Euler-Chelpin, M. (My), Anttila, A. (Ahti), Fitzpatrick, P. (Patricia), Mano, M.P. (Maria Piera), Kawai, M. (Masaaki), Scharpantgen, A. (A.), Fracheboud, J. (Jacques), Hofvind, S. (Solveig), Vidal, C. (Carmen), Ascunce, N. (Nieves), Salas, D. (Dolores), Bulliard, J.-L. (Jean-Luc), Segnan, N. (Nereo), Kerlikowske, K. (Karla), and Taplin, S. (Stephen)

Abstract

Results Twelve countries contributed data from a total of 15 screening programmes, all from Europe except the United States of America and Japan. Among women aged 50-69 years, 7,176,050 screening tests and 5324 screen-detected DCIS were reported. From 21% to 93% of DCIS had a pre-operative diagnosis (PO); 67-90% of DCIS received breast conservation surgery (BCS), and in 41-100% of the cases this was followed by radiotherapy; 6.4-59% received sentinel lymph node biopsy (SLNB) only and 0.8-49% axillary dissection (ALND) with 0.6% (range by programmes 0-8.1%) being node positive. Among BCS patients 35% received SLNB only and 4.8% received ALND. Starting in 2006, PO and SLNB use increased while ALND remained stable. SLNB and ALND were associated with larger size and higher grade DCIS lesions.Conclusions Variation in DCIS management among screened women is wide and includes lymph node surgery beyond what is currently recommended. This indicates the presence of varying levels of overtreatment and the potential for its reduction.Background Ductal carcinoma in situ (DCIS) incidence has grown with the implementation of screening and its detection varies across International Cancer Screening Network (ICSN) countries. The aim of this survey is to describe the management of screen-detected DCIS in ICSN countries and to evaluate the potential for treatment related morbidity.Methods We sought screen-detected DCIS data from the ICSN countries identified during 2004-2008. We adopted standardised data collection forms and analysis and explored DCIS diagnosis and treatment processes ranging from pre-operative diagnosis to type of surgery and radiotherapy.

Published
2014
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19. Mammographic screening programmes in Europe:organization, coverage and participation

Author

Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, Lancucki, L, Giordano, Livia, von Karsa, Lawrence, Tomatis, Mariano, Majek, Ondrej, de Wolf, Chris, Lancucki, Lesz, Hofvind, Solveig, Nyström, Lennarth, Segnan, Nereo, Ponti, Antonio, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, My Catarina, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick J, J, and Lancucki, L

Abstract

To summarize participation and coverage rates in population mammographic screening programmes for breast cancer in Europe.

Published
2012

20. False-positive results in mammographic screening for breast cancer in Europe:a literature review and survey of service screening programmes

Author

Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, Ducarroz, S, Hofvind, Solveig, Ponti, Antonio, Patnick, Julietta, Ascunce, Nieves, Njor, Sisse Helle, Broeders, Mireille, Giordano, Livia, Frigerio, Alfonso, Törnberg, Sven, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, M J, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, S B, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, and Ducarroz, S

Abstract

To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment.

Published
2012

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