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469 results on '"Méndez Ferrer, Simón"'

1. Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms

Author

Grockowiak, Elodie, Korn, Claudia, Rak, Justyna, Lysenko, Veronika, Hallou, Adrien, Panvini, Francesca M., Williams, Matthew, Fielding, Claire, Fang, Zijian, Khatib-Massalha, Eman, García-García, Andrés, Li, Juan, Khorshed, Reema A., González-Antón, Sara, Baxter, E. Joanna, Kusumbe, Anjali, Wilkins, Bridget S., Green, Anna, Simons, Benjamin D., Harrison, Claire N., Green, Anthony R., Lo Celso, Cristina, Theocharides, Alexandre P. A., and Méndez-Ferrer, Simón

Published
2023
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3. Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis

Author

Fang, Zijian, Corbizi Fattori, Giuditta, McKerrell, Thomas, Boucher, Rebecca H., Jackson, Aimee, Fletcher, Rachel S., Forte, Dorian, Martin, Jose-Ezequiel, Fox, Sonia, Roberts, James, Glover, Rachel, Harris, Erica, Bridges, Hannah R., Grassi, Luigi, Rodriguez-Meira, Alba, Mead, Adam J., Knapper, Steven, Ewing, Joanne, Butt, Nauman M., Jain, Manish, Francis, Sebastian, Clark, Fiona J., Coppell, Jason, McMullin, Mary F., Wadelin, Frances, Narayanan, Srinivasan, Milojkovic, Dragana, Drummond, Mark W., Sekhar, Mallika, ElDaly, Hesham, Hirst, Judy, Paramor, Maike, Baxter, E. Joanna, Godfrey, Anna L., Harrison, Claire N., and Méndez-Ferrer, Simón

Published
2023
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4. The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells

Author

Viñado, Ana C., Calvo, Isabel A., Cenzano, Itziar, Olaverri, Danel, Cocera, Miguel, San Martin-Uriz, Patxi, Romero, Juan P., Vilas-Zornoza, Amaia, Vera, Laura, Gomez-Cebrian, Nuria, Puchades-Carrasco, Leonor, Lisi-Vega, Livia E., Apaolaza, Iñigo, Valera, Pablo, Guruceaga, Elisabeth, Granero-Molto, Froilan, Ripalda-Cemborain, Purificacion, Luck, Tamara J., Bullinger, Lars, Planes, Francisco J., Rifon, José J., Méndez-Ferrer, Simón, Yusuf, Rushdia Z., Pardo-Saganta, Ana, Prosper, Felipe, and Saez, Borja

Published
2022
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8. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

Author

Gadomski, Stephen, Fielding, Claire, García-García, Andrés, Korn, Claudia, Kapeni, Chrysa, Ashraf, Sadaf, Villadiego, Javier, Toro, Raquel del, Domingues, Olivia, Skepper, Jeremy N., Michel, Tatiana, Zimmer, Jacques, Sendtner, Regine, Dillon, Scott, Poole, Kenneth E.S., Holdsworth, Gill, Sendtner, Michael, Toledo-Aral, Juan J., De Bari, Cosimo, McCaskie, Andrew W., Robey, Pamela G., and Méndez-Ferrer, Simón

Published
2022
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13. Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Author

Forte, Dorian, García-Fernández, María, Sánchez-Aguilera, Abel, Stavropoulou, Vaia, Fielding, Claire, Martín-Pérez, Daniel, López, Juan Antonio, Costa, Ana S.H., Tronci, Laura, Nikitopoulou, Efterpi, Barber, Michael, Gallipoli, Paolo, Marando, Ludovica, Fernández de Castillejo, Carlos López, Tzankov, Alexandar, Dietmann, Sabine, Cavo, Michele, Catani, Lucia, Curti, Antonio, Vázquez, Jesús, Frezza, Christian, Huntly, Brian J., Schwaller, Juerg, and Méndez-Ferrer, Simón

Published
2020
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16. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

Author

Ho, Ya-Hsuan, del Toro, Raquel, Rivera-Torres, José, Rak, Justyna, Korn, Claudia, García-García, Andrés, Macías, David, González-Gómez, Cristina, del Monte, Alberto, Wittner, Monika, Waller, Amie K., Foster, Holly R., López-Otín, Carlos, Johnson, Randall S., Nerlov, Claus, Ghevaert, Cedric, Vainchenker, William, Louache, Fawzia, Andrés, Vicente, and Méndez-Ferrer, Simón

Published
2019
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21. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

Author

Golan, Karin, Kumari, Anju, Kollet, Orit, Khatib-Massalha, Eman, Subramaniam, Mohana Devi, Ferreira, Zulma S., Avemaria, Francesca, Rzeszotek, Sylwia, García-García, Andrés, Xie, Stephanie, Flores-Figueroa, Eugenia, Gur-Cohen, Shiri, Itkin, Tomer, Ludin-Tal, Aya, Massalha, Hassan, Bernshtein, Biana, Ciechanowicz, Andrzej K., Brandis, Alexander, Mehlman, Tevie, Bhattacharya, Suditi, Bertagna, Mayla, Cheng, Hui, Petrovich-Kopitman, Ekaterina, Janus, Tomasz, Kaushansky, Nathali, Cheng, Tao, Sagi, Irit, Ratajczak, Mariusz Z., Méndez-Ferrer, Simón, Dick, John E., Markus, Regina P., and Lapidot, Tsvee

Published
2018
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28. IL-1β promotes MPN disease initiation by favoring early clonal expansion ofJAK2-mutant hematopoietic stem cells

Author

Rai, Shivam, primary, Zhang, Yang, additional, Grockowiak, Elodie, additional, Kimmerlin, Quentin, additional, Hansen, Nils, additional, Stoll, Cedric B., additional, Usart, Marc, additional, Hao-Shen, Hui, additional, Bader, Michael S., additional, Passweg, Jakob, additional, Dirnhofer, Stefan, additional, Farady, Christopher J., additional, Schroeder, Timm, additional, Méndez-Ferrer, Simón, additional, and Skoda, Radek C., additional

Published
2023
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29. A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics

Author

García-Marqués, Fernando, Trevisan-Herraz, Marco, Martínez-Martínez, Sara, Camafeita, Emilio, Jorge, Inmaculada, Lopez, Juan Antonio, Méndez-Barbero, Nerea, Méndez-Ferrer, Simón, del Pozo, Miguel Angel, Ibáñez, Borja, Andrés, Vicente, Sánchez-Madrid, Francisco, Redondo, Juan Miguel, Bonzon-Kulichenko, Elena, and Vázquez, Jesús

Published
2016
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34. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Author

Saez, Borja, Ferraro, Francesca, Yusuf, Rushdia Z., Cook, Colleen M., Yu, Vionnie W.C., Pardo-Saganta, Ana, Sykes, Stephen M., Palchaudhuri, Rahul, Schajnovitz, Amir, Lotinun, Sutada, Lymperi, Stefania, Mendez-Ferrer, Simon, Toro, Raquel del, Day, Robyn, Vasic, Radovan, Acharya, Sanket S., Baron, Roland, Lin, Charles P., Yamaguchi, Yu, Wagers, Amy J., and Scadden, David T.

Published
2014
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36. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Author

Mangolini, Maurizio, Götte, Frederik, Moore, Andrew, Ammon, Tim, Oelsner, Madlen, Lutzny-Geier, Gloria, Klein-Hitpass, Ludger, Williamson, James C., Lehner, Paul J., Dürig, Jan, Möllmann, Michael, Rásó-Barnett, Lívia, Hughes, Katherine, Santoro, Antonella, Méndez-Ferrer, Simón, Oostendorp, Robert A. J., Zimber-Strobl, Ursula, Peschel, Christian, Hodson, Daniel J., Schmidt-Supprian, Marc, and Ringshausen, Ingo

Published
2018
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44. Stem cells 'aclymatise' to regenerate the blood system

Author

Lisi-Vega, Livia E, Méndez-Ferrer, Simón, Mendez-Ferrer, Simon [0000-0002-9805-9988], and Apollo - University of Cambridge Repository

Subjects
Carcinogenesis, Humans, Hematopoietic Stem Cells, Epigenesis, Genetic, Hematopoiesis
Abstract

How blood stem cells balance fate decisions between quiescence maintenance and differentiation during recovery from cancer treatment remains poorly understood. A recent study by Umemoto et al (2022) uncovers an unexpected linkage between metabolic and epigenetic regulation of haematopoiesis, suggesting new targets in haematopoietic regeneration, with possible implications in leukaemogenesis and therapy resistance.

Published
2022
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45. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.

Author

Valet, Colin, Valet, Colin, Magnen, Mélia, Qiu, Longhui, Cleary, Simon J, Wang, Kristin M, Ranucci, Serena, Grockowiak, Elodie, Boudra, Rafik, Conrad, Catharina, Seo, Yurim, Calabrese, Daniel R, Greenland, John R, Leavitt, Andrew D, Passegué, Emmanuelle, Méndez-Ferrer, Simón, Swirski, Filip K, Looney, Mark R, Valet, Colin, Valet, Colin, Magnen, Mélia, Qiu, Longhui, Cleary, Simon J, Wang, Kristin M, Ranucci, Serena, Grockowiak, Elodie, Boudra, Rafik, Conrad, Catharina, Seo, Yurim, Calabrese, Daniel R, Greenland, John R, Leavitt, Andrew D, Passegué, Emmanuelle, Méndez-Ferrer, Simón, Swirski, Filip K, and Looney, Mark R

Abstract

Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet production and phenotypes of resultant platelets. Here, we showed during sepsis that the spleen was a major site of megakaryopoiesis and platelet production. Sepsis provoked an adrenergic-dependent mobilization of megakaryocyte-erythrocyte progenitors (MEPs) from the bone marrow to the spleen, where IL-3 induced their differentiation into megakaryocytes (MKs). In the spleen, immune-skewed MKs produced a CD40 ligandhi platelet population with potent immunomodulatory functions. Transfusions of post-sepsis platelets enriched from splenic production enhanced immune responses and reduced overall mortality in sepsis-challenged animals. These findings identify a spleen-derived protective platelet population that may be broadly immunomodulatory in acute inflammatory states such as sepsis.

Published
2022

46. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.

Author

Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Gadomski, Stephen, Fielding, Claire, García García, Andrés, Korn, Claudia, Kapeni, Chrysa, Ashraf, Sadaf, Villadiego Luque, Francisco Javier, Toro Estévez, Raquel del, Toledo Aral, Juan José, Méndez Ferrer, Simón, Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Gadomski, Stephen, Fielding, Claire, García García, Andrés, Korn, Claudia, Kapeni, Chrysa, Ashraf, Sadaf, Villadiego Luque, Francisco Javier, Toro Estévez, Raquel del, Toledo Aral, Juan José, and Méndez Ferrer, Simón

Abstract

The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sym pathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers un dergoes an interleukin-6 (IL-6)-induced cholinergic switch upon contacting the bone. A neurotrophic depen dency mediated through GDNF-family receptor-a2 (GFRa2) and its ligand, neurturin (NRTN), is established between sympathetic cholinergic fibers and bone-embedded osteocytes, which require cholinergic innerva tion for their survival and connectivity. Bone-lining osteoprogenitors amplify and propagate cholinergic signals in the bone marrow (BM). Moderate exercise augments trabecular bone partly through an IL-6-depen dent expansion of sympathetic cholinergic nerve fibers. Consequently, loss of cholinergic skeletal innerva tion reduces osteocyte survival and function, causing osteopenia and impaired skeletal adaptation to mod erate exercise. These results uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.

Published
2022

47. Supplemental Information. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

Author

Gadomski, Stephen, Fielding, Claire, García-García, Andrés, Korn, Claudia, Kapeni, Chrysa, Ashraf, Sadaf, Villadiego, Javier, Toro, Raquel del, Domingues, Olivia, Skepper, Jeremy N., Michel, Tatiana, Zimmer, Jacques, Sendtner, Regine, Dillon, Scott, Poole, Kenneth E. S., Holdsworth, Gill, Sendtner, Michael, Toledo-Aral, Juan José, De Bari, Cosimo, McCaskie, Andrew W., Robey, Pamela G., Méndez-Ferrer, Simón, Gadomski, Stephen, Fielding, Claire, García-García, Andrés, Korn, Claudia, Kapeni, Chrysa, Ashraf, Sadaf, Villadiego, Javier, Toro, Raquel del, Domingues, Olivia, Skepper, Jeremy N., Michel, Tatiana, Zimmer, Jacques, Sendtner, Regine, Dillon, Scott, Poole, Kenneth E. S., Holdsworth, Gill, Sendtner, Michael, Toledo-Aral, Juan José, De Bari, Cosimo, McCaskie, Andrew W., Robey, Pamela G., and Méndez-Ferrer, Simón

Published
2022

48. Megakaryocyte Diversity in Ontogeny, Functions and Cell-Cell Interactions

Author

Council for Higher Education (Israel), Weizmann Institute of Science, Wellcome Trust, MRC Cambridge Stem Cell Institute, National Health Service (UK), European Commission, Japan Agency for Medical Research and Development, Cancer Research UK, Khatib-Massalha, Eman, Méndez-Ferrer, Simón, Council for Higher Education (Israel), Weizmann Institute of Science, Wellcome Trust, MRC Cambridge Stem Cell Institute, National Health Service (UK), European Commission, Japan Agency for Medical Research and Development, Cancer Research UK, Khatib-Massalha, Eman, and Méndez-Ferrer, Simón

Abstract

Hematopoietic stem cells (HSCs) rely on local interactions in the bone marrow (BM) microenvironment with stromal cells and other hematopoietic cells that facilitate their survival and proliferation, and also regulate their functions. HSCs and multipotent progenitor cells differentiate into lineage-specific progenitors that generate all blood and immune cells. Megakaryocytes (Mks) are hematopoietic cells responsible for producing blood platelets, which are essential for normal hemostasis and blood coagulation. Although the most prominent function of Mks is platelet production (thrombopoiesis), other increasingly recognized functions include HSC maintenance and host immune response. However, whether and how these diverse programs are executed by different Mk subpopulations remains poorly understood. This Perspective summarizes our current understanding of diversity in ontogeny, functions and cell-cell interactions. Cumulative evidence suggests that BM microenvironment dysfunction, partly caused by mutated Mks, can induce or alter the progression of a variety of hematologic malignancies, including myeloproliferative neoplasms (MPNs) and other disorders associated with tissue scarring (fibrosis). Therefore, as an example of the heterogeneous functions of Mks in malignant hematopoiesis, we will discuss the role of Mks in the onset and progression of BM fibrosis. In this regard, abnormal interactions between of Mks and other immune cells might directly contribute to fibrotic diseases. Overall, further understanding of megakaryopoiesis and how Mks interact with HSCs and immune cells has potential clinical implications for stem cell transplantation and other therapies for hematologic malignancies, as well as for treatments to stimulate platelet production and prevent thrombocytopenia.

Published
2022

49. The EHA Research Roadmap:Hematopoietic Stem Cells and Allotransplantation

Author

Fibbe, Willem, Bernardi, Rosa, Charbord, Pierre, Krause, Daniela, Lo Celso, Cristina, Méndez-Ferrer, Simón, Mummery, Christine, Oostendorp, Robert, Raaijmakers, Marc, Socié, Gerard, Staal, Frank, Bacigalupo, Andrea, Fibbe, Willem, Bernardi, Rosa, Charbord, Pierre, Krause, Daniela, Lo Celso, Cristina, Méndez-Ferrer, Simón, Mummery, Christine, Oostendorp, Robert, Raaijmakers, Marc, Socié, Gerard, Staal, Frank, and Bacigalupo, Andrea

Published
2022

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