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Deutsch: Im Rahmen der NFDI4Biodiversity All Hands Conference vom 12.-14. Oktober 2022 stellt sich die Task Area 2 Measure 3 kurz vor und bietet einen Überblick über die Aktivitäten im Zuge der Harmonisierungsbemühungen im Bereich Metadaten und Datenaustausch des Konsortiums. Die beiden als vielversprechend identifizierten Kandidaten für die erleichterte Auffindbarkeit sowie der semantische Annotation von Daten der Biodiversitätsforschung im Allgemeinen ((bio)schema.org), und der detaillierten inhaltlichen Beschreibung von Daten biologischer Sammlungen im Speziellen werden kurz vorgestellt, um im Fall von bioschemas mit einigen Hintergründen unterfüttert. English: As part of the NFDI4Biodiversity All Hands Conference, October 12-14, 2022, Task Area 2 Measure 3 briefly introduces itself and provides an overview of activities underway in the Consortium's metadata and data exchange harmonization efforts. The two candidates identified as promising for facilitating discoverability as well as semantic annotation of biodiversity research data in general ((bio)schema.org), and detailed content description of biological collections data in particular are briefly presented, and are backed up with some background in terms of bioschemas mark-up.

Background and aimsNon-thyroidal illness syndrome (NTIS) is frequent in critically ill patients and associated with adverse outcomes. We aimed to characterize the evolution of NTIS in patients with acute decompensation (AD) of cirrhosis and acute-on-chronic liver failure (ACLF), since NTIS is not well described in these newly defined syndromes.MethodsThyroid hormones (TH) were quantified at baseline in consecutive patients with cirrhosis. In addition, 76 inflammatory mediators were quantified by proximity extension analysis assay in a subgroup of patients. Associations between TH, cirrhosis stage, mortality and inflammation were assessed.ResultsOverall, 437 patients were included, of whom 165 (37.8%), 211 (48.3%), and 61 (14%) had compensated cirrhosis (CC), AD, and ACLF. FT3 concentrations were lower in AD versus CC, and further decreased in ACLF. Importantly, NTIS was present in 83 (39.3%) patients with AD and in 44 (72.1%) patients with ACLF (P3-ratio, thyroid index) showed an U-shaped evolution during progression of cirrhosis, suggesting a partially preserved responsiveness of the hypothalamus and pituitary in AD. Infections were associated with lower FT3 concentrations in AD, but not in ACLF. Low FT3 concentrations correlated significantly with 90-day mortality. Both, AD/ACLF and NTIS, were associated with signatures of inflammatory mediators, which were partially non-overlapping.ConclusionNTIS is frequent already in AD and therefore precedes critically illness in a subgroup of patients with decompensated cirrhosis. This might constitute a new paradigm of TH signaling in cirrhosis, offering opportunities to explore preventive effects of TH in AD.

Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].

Over the past few years, growing evidence suggests direct crosstalk between thyroid hormones (THs) and the immune system. Components of the immune system were proposed to interfere with the central regulation of systemic TH levels. Conversely, THs regulate innate and adaptive immune responses as immune cells are direct target cells of THs. Accordingly, they express different components of local TH action, such as TH transporters or receptors, but our picture of the interplay between THs and the immune system is still incomplete. This review provides a critical overview of current knowledge regarding the interaction of THs and the immune system with the main focus on local TH action within major innate and adaptive immune cell subsets. Thereby, this review aims to highlight open issues which might help to infer the clinical relevance of THs in host defence in the context of different types of diseases such as infection, ischemic organ injury or cancer.

Purpose: Thyroid hormones (TH) play a central role for cardiac function. TH influence heart rate and cardiac contractility, and altered thyroid function is associated with increased cardiovascular morbidity and mortality. The precise role of TH in onset and progression of heart failure still requires clarification. Methods: Chronic left ventricular pressure overload was induced in mouse hearts by transverse aortic constriction (TAC). One week after TAC, alteration of TH status was induced and the impact on cardiac disease progression was studied longitudinally over 4 weeks in mice with hypo- or hyperthyroidism and was compared to euthyroid TAC controls. Serial assessment was performed for heart function (2D M-mode echocardiography), heart morphology (weight, fibrosis, and cardiomyocyte cross-sectional area), andmolecular changes in heart tissues (TH target gene expression, apoptosis, and mTOR activation) at 2 and 4 weeks. Results: In diseased heart, subsequent TH restriction stopped progression of maladaptive cardiac hypertrophy and improved cardiac function. In contrast and compared to euthyroid TAC controls, increased TH availability after TAC propelled maladaptive cardiac growth and development of heart failure. This was accompanied by a rise in cardiomyocyte apoptosis and mTOR pathway activation. Conclusion: This study shows, for the first time, a protective effect of TH deprivation against progression of pathological cardiac hypertrophy and development of congestive heart failure in mice with left ventricular pressure overload. Whether this also applies to the human situation needs to be determined in clinical studies and would infer a critical re-thinking of management of TH status in patients with hypertensive heart disease. OA Förderung 2021

Presentation about metadata curation for DataCite Open Hours on 7 July 2021

Supplemental material, 2020-00018R1_Production_Supplemental_Data_online_supp for Diagnostic Electron Microscopy of Viruses With Low-voltage Electron Microscopes by Lars Möller, Gudrun Holland and Michael Laue in Journal of Histochemistry & Cytochemistry