7 results on '"Mühlschlegel, Friedrich"'
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2. Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study
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Pleininger, Sonja, Indra, Alexander, De Baetselier, Irith, Vanden Berghe, Wim, Hunjak, Blaženka, Blažić, Tatjana Nemeth, Maikanti-Charalambous, Panayiota, Pieridou, Despo, Zákoucká, Hana, Žemličková, Helena, Hoffmann, Steen, Cowan, Susan, Schwartz, Lasse Jessen, Peetso, Rita, Epstein, Jevgenia, Viktorova, Jelena, Ndeikoundam, Ndeindo, Bercot, Beatrice, Bébéar, Cécile, Lot, Florence, Buder, Susanne, Jansen, Klaus, Miriagou, Vivi, Rigakos, Georgios, Raftopoulos, Vasilios, Balla, Eszter, Dudás, Mária, Ásmundsdóttir, Lena Rós, Sigmundsdóttir, Guðrún, Hauksdóttir, Guðrún Svanborg, Gudnason, Thorolfur, Colgan, Aoife, Crowley, Brendan, Saab, Sinéad, Stefanelli, Paola, Carannante, Anna, Parodi, Patrizia, Pakarna, Gatis, Nikiforova, Raina, Bormane, Antra, Dimina, Elina, Perrin, Monique, Abdelrahman, Tamir, Mossong, Joël, Schmit, Jean-Claude, Mühlschlegel, Friedrich, Barbara, Christopher, Mifsud, Francesca, Van Dam, Alje, Van Benthem, Birgit, Visser, Maartje, Linde, Ineke, Kløvstad, Hilde, Caugant, Dominique, Młynarczyk-Bonikowska, Beata, Azevedo, Jacinta, Borrego, Maria-José, Nascimento, Marina Lurdes Ramos, Pavlik, Peter, Klavs, Irena, Murnik, Andreja, Jeverica, Samo, Kustec, Tanja, Vázquez Moreno, Julio, Diaz, Asuncion, Abad, Raquel, Velicko, Inga, Unemo, Magnus, Fifer, Helen, Shepherd, Jill, Patterson, Lynsey, Sánchez-Busó, Leonor, Cole, Michelle J, Spiteri, Gianfranco, Day, Michaela, Jacobsson, Susanne, Golparian, Daniel, Sajedi, Noshin, Yeats, Corin A, Abudahab, Khalil, Underwood, Anthony, Bluemel, Benjamin, and Aanensen, David M
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- 2022
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3. Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study
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Sánchez-Busó, Leonor, primary, Cole, Michelle J, additional, Spiteri, Gianfranco, additional, Day, Michaela, additional, Jacobsson, Susanne, additional, Golparian, Daniel, additional, Sajedi, Noshin, additional, Yeats, Corin A, additional, Abudahab, Khalil, additional, Underwood, Anthony, additional, Bluemel, Benjamin, additional, Aanensen, David M, additional, Unemo, Magnus, additional, Pleininger, Sonja, additional, Indra, Alexander, additional, De Baetselier, Irith, additional, Vanden Berghe, Wim, additional, Hunjak, Blaženka, additional, Blažić, Tatjana Nemeth, additional, Maikanti-Charalambous, Panayiota, additional, Pieridou, Despo, additional, Zákoucká, Hana, additional, Žemličková, Helena, additional, Hoffmann, Steen, additional, Cowan, Susan, additional, Schwartz, Lasse Jessen, additional, Peetso, Rita, additional, Epstein, Jevgenia, additional, Viktorova, Jelena, additional, Ndeikoundam, Ndeindo, additional, Bercot, Beatrice, additional, Bébéar, Cécile, additional, Lot, Florence, additional, Buder, Susanne, additional, Jansen, Klaus, additional, Miriagou, Vivi, additional, Rigakos, Georgios, additional, Raftopoulos, Vasilios, additional, Balla, Eszter, additional, Dudás, Mária, additional, Ásmundsdóttir, Lena Rós, additional, Sigmundsdóttir, Guðrún, additional, Hauksdóttir, Guðrún Svanborg, additional, Gudnason, Thorolfur, additional, Colgan, Aoife, additional, Crowley, Brendan, additional, Saab, Sinéad, additional, Stefanelli, Paola, additional, Carannante, Anna, additional, Parodi, Patrizia, additional, Pakarna, Gatis, additional, Nikiforova, Raina, additional, Bormane, Antra, additional, Dimina, Elina, additional, Perrin, Monique, additional, Abdelrahman, Tamir, additional, Mossong, Joël, additional, Schmit, Jean-Claude, additional, Mühlschlegel, Friedrich, additional, Barbara, Christopher, additional, Mifsud, Francesca, additional, Van Dam, Alje, additional, Van Benthem, Birgit, additional, Visser, Maartje, additional, Linde, Ineke, additional, Kløvstad, Hilde, additional, Caugant, Dominique, additional, Młynarczyk-Bonikowska, Beata, additional, Azevedo, Jacinta, additional, Borrego, Maria-José, additional, Nascimento, Marina Lurdes Ramos, additional, Pavlik, Peter, additional, Klavs, Irena, additional, Murnik, Andreja, additional, Jeverica, Samo, additional, Kustec, Tanja, additional, Vázquez Moreno, Julio, additional, Diaz, Asuncion, additional, Abad, Raquel, additional, Velicko, Inga, additional, Fifer, Helen, additional, Shepherd, Jill, additional, and Patterson, Lynsey, additional
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- 2022
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4. Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions
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Baldini, Federico, Hertel, Johannes, Sandt, Estelle, Thinnes, Cyrille C., Neuberger-Castillo, Lorieza, Pavelka, Lukas, Betsou, Fay, Krüger, Rejko, Thiele, Ines, Aguayo, Gloria, Allen, Dominic, Ammerlann, Wim, Aurich, Maike, Balling, Rudi, Banda, Peter, Beaumont, Katy, Becker, Regina, Berg, Daniela, Binck, Sylvia, Bisdorff, Alexandre, Bobbili, Dheeraj, Brockmann, Kathrin, Calmes, Jessica, Castillo, Lorieza, Diederich, Nico, Dondelinger, Rene, Esteves, Daniela, Ferrand, Jean-Yves, Fleming, Ronan, Gantenbein, Manon, Gasser, Thomas, Gawron, Piotr, Geffers, Lars, Giarmana, Virginie, Glaab, Enrico, Gomes, Clarissa P. C., Goncharenko, Nikolai, Graas, Jérôme, Graziano, Mariela, Groues, Valentin, Grünewald, Anne, Gu, Wei, Hammot, Gaël, Hanff, Anne-Marie, Hansen, Linda, Hansen, Maxime, Haraldsdöttir, Hulda, Heirendt, Laurent, Herbrink, Sylvia, Herzinger, Sascha, Heymann, Michael, Hiller, Karsten, Hipp, Geraldine, Hu, Michele, Huiart, Laetitia, Hundt, Alexander, Jacoby, Nadine, Jarosław, Jacek, Jaroz, Yohan, Kolber, Pierre, Kutzera, Joachim, Landoulsi, Zied, Larue, Catherine, Lentz, Roseline, Liepelt, Inga, Liszka, Robert, Longhino, Laura, Lorentz, Victoria, Mackay, Clare, Maetzler, Walter, Marcus, Katrin, Marques, Guilherme, Martens, Jan, Mathay, Conny, Matyjaszczyk, Piotr, May, Patrick, Meisch, Francoise, Menster, Myriam, Minelli, Maura, Mittelbronn, Michel, Mollenhauer, Brit, Mommaerts, Kathleen, Moreno, Carlos, Mühlschlegel, Friedrich, Nati, Romain, Nehrbass, Ulf, Nickels, Sarah, Nicolai, Beatrice, Nicolay, Jean-Paul, Noronha, Alberto, Oertel, Wolfgang, Ostaszewski, Marek, Pachchek, Sinthuja, Pauly, Claire, Perquin, Magali, Reiter, Dorothea, Rosety, Isabel, Rump, Kirsten, Satagopam, Venkata, Schlesser, Marc, Schmitz, Sabine, Schmitz, Susanne, Schneider, Reinhard, Schwamborn, Jens, Schweicher, Alexandra, Simons, Janine, Stute, Lara, Trefois, Christophe, Trezzi, Jean-Pierre, Vaillant, Michel, Vasco, Daniel, Vyas, Maharshi, Wade-Martins, Richard, and Wilmes, Paul
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Male ,Systemic disease ,Parkinson's disease ,Physiology ,Luxembourg ,Plant Science ,Disease ,Transsulfuration pathway ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Structural Biology ,RNA, Ribosomal, 16S ,Pantothenic acid ,medicine ,Humans ,Microbiome ,lcsh:QH301-705.5 ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,Aged ,Metabolic modelling ,0303 health sciences ,Gut microbiome ,Methionine ,Dopaminergic ,Parkinson Disease ,Cell Biology ,Middle Aged ,medicine.disease ,3. Good health ,Gastrointestinal Microbiome ,RNA, Bacterial ,chemistry ,Computational modelling ,lcsh:Biology (General) ,Case-Control Studies ,Parkinson’s disease ,Female ,General Agricultural and Biological Sciences ,030217 neurology & neurosurgery ,Developmental Biology ,Biotechnology ,Research Article - Abstract
Background Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson’s Study (n = 147 typical PD cases, n = 162 controls). Results All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed by self-reporting questionnaires. Stool samples from these individuals were first analysed by 16S rRNA gene sequencing. Second, we predicted the potential secretion for 129 microbial metabolites through personalised metabolic modelling using the microbiome data and genome-scale metabolic reconstructions of human gut microbes. Our key results include the following. Eight genera and seven species changed significantly in their relative abundances between PD patients and healthy controls. PD-associated microbial patterns statistically depended on sex, age, BMI, and constipation. Particularly, the relative abundances of Bilophila and Paraprevotella were significantly associated with the Hoehn and Yahr staging after controlling for the disease duration. Furthermore, personalised metabolic modelling of the gut microbiomes revealed PD-associated metabolic patterns in the predicted secretion potential of nine microbial metabolites in PD, including increased methionine and cysteinylglycine. The predicted microbial pantothenic acid production potential was linked to the presence of specific non-motor symptoms. Conclusion Our results suggest that PD-associated alterations of the gut microbiome can translate into substantial functional differences affecting host metabolism and disease phenotype.
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- 2020
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5. Characterization and Diversity of 243 Complete Human Papillomavirus Genomes in Cervical Swabs Using Next Generation Sequencing
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Latsuzbaia, Ardashel, primary, Wienecke-Baldacchino, Anke, additional, Tapp, Jessica, additional, Arbyn, Marc, additional, Karabegović, Irma, additional, Chen, Zigui, additional, Fischer, Marc, additional, Mühlschlegel, Friedrich, additional, Weyers, Steven, additional, Pesch, Pascale, additional, and Mossong, Joël, additional
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- 2020
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6. Precision Antifungal Treatment Significantly Extends Voice Prosthesis Lifespan in Patients Following Total Laryngectomy
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Pentland, Daniel R., primary, Stevens, Sarah, additional, Williams, Leila, additional, Baker, Mark, additional, McCall, Carolyn, additional, Makarovaite, Viktorija, additional, Balfour, Alistair, additional, Mühlschlegel, Friedrich A., additional, and Gourlay, Campbell W., additional
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- 2020
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7. Circulating Anodic and Cathodic Antigen in Serum and Urine from Schistosoma haematobium-Infected Cameroonian Children Receiving Praziquantel: A Longitudinal Study.
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Kremsner, Peter G., Enyong, Peter, Krijger, Frederik W., De Jonge, Niels, Zotter, Gertraud M., Thalhammer, Florian, Mühlschlegel, Friedrich, Bienzle, Ulrich, Feldmeier, Hermann, and Deelder, André M.
- Abstract
A cohort of 148 Cameroonian children infected with Schistosoma haematobium was followed before praziquantel therapy and 1,2,3,5, and 12 months thereafter. Egg output, the reagent strip index (RSI, a pathological marker), and circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) in serum and urine were quantified. At enrollment, the median level of egg output was 365/10 mL of urine; 97% of children had a positive RSI; CAA was detected in serum from 76% of children and in urine from 64%; and CCA was detected in serum from 55% of children and in urine from 87%. Two months after chemotherapy, egg output and RSI had decreased significantly; reinfection later developed in parallel with increases in the serum and urine concentrations of CAA and the urine concentrations of CCA. The measurement of CAA and CCA is useful for diagnosis, evaluation of disease severity, and follow-up of chemotherapy in individuals infected with S. haematobium. [ABSTRACT FROM PUBLISHER]
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- 1994
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