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34 results on '"Mürtz, Manfred"'

7. Kinetics and biological responses of dermal application of nitric oxide in vivo: Therapeutical potential in humans

Author

Opländer, Christian, primary, Römer, Ariane, additional, Paunel-Görgülü, Adnana, additional, Fritsch, Thomas, additional, Faassen, Ernst van, additional, Mürtz, Manfred, additional, Bozkurt, Ahmet, additional, Grieb, Gerrit, additional, Fuchs, Paul, additional, Pallua, Norbert, additional, and Suschek, Christoph, additional

Published
2012
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8. Dermal application of nitric oxide releasing acidified nitrite-containing liniments significantly reduces blood pressure in humans

Author

Opländer, Christian, primary, Volkmar, Christine M., additional, Paunel-Görgülü, Adnana, additional, Fritsch, Thomas, additional, van Faassen, Ernst E., additional, Mürtz, Manfred, additional, Grieb, Gerrit, additional, Bozkurt, Ahmet, additional, Hemmrich, Karsten, additional, Windolf, Joachim, additional, and Suschek, Christoph V., additional

Published
2012
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10. Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates

Author

Opländer, Christian, primary, Volkmar, Christine M., additional, Paunel-Görgülü, Adnana, additional, van Faassen, Ernst E., additional, Heiss, Christian, additional, Kelm, Malte, additional, Halmer, Daniel, additional, Mürtz, Manfred, additional, Pallua, Norbert, additional, and Suschek, Christoph V., additional

Published
2009
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21. The presence of nitrite during UVA irradiation protects from apoptosis

Author

Suschek, Christoph V., primary, Schroeder, Peter, additional, Aust, Olivier, additional, Sies, Helmut, additional, Mahotka, Csaba, additional, Horstjann, Markus, additional, Ganser, Heiko, additional, Mürtz, Manfred, additional, Hering, Peter, additional, Schnorr, Oliver, additional, Kröncke, Klaus‐Dietrich, additional, and Kolb‐Bachofen, Victoria, additional

Published
2003
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22. Laser Spectroscopic Online Monitoring of Volatile Diseasemarkers in Human Breath.

Author

Buzug, Thorsten M., Holz, Dietrich, Bongartz, Jens, Kohl-Bareis, Matthias, Hartmann, Ulrich, Weber, Simone, Mürtz, Manfred, Thelen, Sven, Fritsch, Thomas, and Hering, Peter

Abstract

We present an overview of the recent progress on spectroscopic online monitoring of exhaled breath with mid-infrared coherent sources. The current detection limits of laser spectroscopic approaches are in the picomolar to nanomolar range, depending on the molecular compound. The time resolution of the measurements is down to the sub-second range. This very high sensitivity and time resolution open up exciting perspectives for novel analytical tasks in biomedical research and clinical diagnosis. [ABSTRACT FROM AUTHOR]

Published
2007
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23. Online Monitoring of Exhaled Breath Using Mid-Infrared Laser Spectroscopy.

Author

Ebrahim-Zadeh, Majid, Sorokina, Irina T., Mürtz, Manfred, and Hering, Peter

Abstract

This review describes the merits of laser-assisted analytical instrumentation for biomedical diagnostics. In particular, we present an overview of the recent progress on spectroscopic online monitoring of exhaled breath with mid-infrared coherent sources. The current detection limits of laser spectroscopic approaches are in the picomolar to nanomolar range, depending on the molecular compound. The time resolution of the measurements is down to the sub-second range. This very high sensitivity and time resolution open up exciting perspectives for novel analytical tasks in biomedical research and clinical diagnosis. Keywords: laser absorption spectroscopy; trace gas monitoring; cavity ring-down; exhaled breath [ABSTRACT FROM AUTHOR]

Published
2007
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31. Time resolved simultaneous detection of 14 NO and 15 NO via mid-infrared cavity leak-out spectroscopy.

Author

Halmer, Daniel, Von Basum, Golo, Horstjann, Markus, Hering, Peter, and Mürtz, Manfred

Subjects
ABSORPTION spectra, INFRARED spectroscopy, ISOTOPES, LASERS, MEDICINE
Abstract

We present a ring-down absorption spectrometer based on a continuous-wave CO laser in the mid-infrared spectral region near λ  =  5 μm. Using a linear ring-down cavity (length: 0.5 m) with high reflective mirrors ( R   =  99.988 %), we observed a noise-equivalent absorption coefficient of 3  ×  10 -10 cm -1 Hz -1/2 . This corresponds to a noise-equivalent concentration of 800 parts per trillion (ppt) for 14 NO and 40 ppt for 15 NO in 1 s averaging time. We achieve a time resolution of 1 s which allows time resolved simultaneous detection of the two N isotopes. The δ 15 N value was obtained with a precision of ±1.2‰ in a sample with a NO fraction of 11 ppm. The simultaneous detection enables the use of 15 NO as a tracer molecule for endogenous biomedical processes. [ABSTRACT FROM AUTHOR]

Published
2005
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33. NO detection in biological samples: Differentiation of 14NO and 15NO using infrared laser spectroscopy

Author

Fritsch, Thomas, Brouzos, Paris, Heinrich, Kathrin, Kelm, Malte, Rassaf, Tienush, Hering, Peter, Kleinbongard, Petra, and Mürtz, Manfred

Subjects
*LASER spectroscopy, *NITROGEN compounds, *SPECTRUM analysis, *BIOCHEMISTRY
Abstract

Abstract: Accurate characterization of the biochemical pathways of nitric oxide (NO) is essential for investigations in the field of NO research. To analyze the different reaction pathways of enzymatic and non-enzymatic NO formation, determination of the source of NO is crucial. Measuring NO-related products in biological samples distinguishing between 14NO and 15NO offers the opportunity to specifically analyze NO signaling in blood and tissue. The aim of this study was to establish a highly sensitive technique for the specific measurement of NO in an isotopologue-selective manner in biological samples. With the cavity leak-out spectroscopy setup (CALOS) a differentiation between 14NO and 15NO is feasible. We describe here the employment of this method for measurements in biological samples. Certified gas mixtures of 14NO/N2 and 15NO/N2 were used to calibrate the system. and of aqueous and biological samples were reduced in a triiodide solution, and the NO released was detected via CALOS. Gas-phase chemiluminescence detection (CLD) was used for evaluation. The correlation received for both methods for the detection of NO in the gas phase was r =0.999, p <0.0001. Results obtained using aqueous and biological samples verified that CALOS enables NO measurements with high accuracy (detection limit for 0.3pmol and 0.5pmol; correlation 14NO: p <0.0001, r =0.975, 15NO: p <0.0001, r =0.969). The CALOS assay represents an extension of NO measurements in biological samples, allowing specific investigations of enzymatic and non-enzymatic NO formation and metabolism in a variety of samples. [Copyright &y& Elsevier]

Published
2008
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34. Time resolved simultaneous detection of 14NO and 15NO via mid-infrared cavity leak-out spectroscopy.

Author

Halmer D, von Basum G, Horstjann M, Hering P, and Mürtz M

Subjects
Lasers, Nitric Oxide chemistry, Spectrophotometry, Infrared instrumentation, Nitric Oxide analysis, Nitrogen Isotopes analysis, Spectrophotometry, Infrared methods
Abstract

We present a ring-down absorption spectrometer based on a continuous-wave CO laser in the mid-infrared spectral region near lambda = 5 microm. Using a linear ring-down cavity (length: 0.5 m) with high reflective mirrors (R = 99.988 %), we observed a noise-equivalent absorption coefficient of 3 x 10(-10) cm(-1)Hz(-1/2). This corresponds to a noise-equivalent concentration of 800 parts per trillion (ppt) for (14)NO and 40 ppt for (15)NO in 1 s averaging time. We achieve a time resolution of 1 s which allows time resolved simultaneous detection of the two N isotopes. The delta(15)N value was obtained with a precision of +/-1.2 per thousand in a sample with a NO fraction of 11 ppm. The simultaneous detection enables the use of (15)NO as a tracer molecule for endogenous biomedical processes.

Published
2005
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