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Your search keyword '"M Mohtasheemul, Hassan"' showing total 2 results
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2 results on '"M Mohtasheemul, Hassan"'

1. Kinetic studies on Zingiber officinale

Author

Amir, Shadmani, Iqbal, Azhar, Farah, Mazhar, M Mohtasheemul, Hassan, Syed Waseemuddin, Ahmed, Iqbal, Ahmad, Khan, Usmanghani, and Sumbul, Shamim

Abstract

The present investigation deals with the isolation, purification and characterization of gingerol, the major pungent constituent of ginger (Zingiber officinale) and its kinetic of extraction using a number of organic solvents. The characterization was carried out through GC and GC-MS. Gingerol has been assayed in the plant material during extraction with various solvents by a HPLC method. In order to develop a relationship between solvent characteristics such as viscosity and dielectric constant and the rates of extraction, the kinetics of extraction of gingerol has been studied by using twelve different solvents in order to evaluate the solvent efficacy in the extraction processes. It has been observed that both solvent viscosity (1/v) and dielectric constant (epsilon) show a linear relationship with the rates of extraction (k). An increase in solvent viscosity leads to a decrease in the rates of extraction, similarly an increase in dielectric constant also leads to a decrease in the rates of extraction. This appears to be largely due to an unionizable character of gingerol which does not interact with polar solvents. Thus solvent viscosity and dielectric constant both play an important role in the choice of solvents for the extraction of gingerol. Solvents with relatively low viscosity and dielectric constant are more suitable for the extraction of gingerol from plant material.

Published
2006

2. Arresting the biosynthesis of Lipid A to hinder Escherichia coli and Pseudomonas aeruginosa through fatty diglyceride.

Author

Khadim Sheikh H, Arshad T, Habib U, Zahra Mirmohammadi S, Usman R, and Mohtasheemul Hassan M

Subjects
Pseudomonas aeruginosa, Diglycerides, Anti-Bacterial Agents chemistry, Microbial Sensitivity Tests, Escherichia coli, Lipid A
Abstract

Lipid A is a fragment of lipopolysaccharide (LPS) in gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa; hence inhibition of its biosynthesis is one of the plausible ways of preventing such bacteria from growth and thus preventing gastrointestinal diseases caused by Escherichia coli and pseudomonas aeruginosa. This research revolves around the development of antibiotic glyceride derivatives for the inhibition of the biosynthesis of lipid A. To target the enzymes involved in the biosynthesis of lipid A, four N,N-dimethylaminobenzoate moiety containing fatty diglyceride derivatives were synthesized through a multi-step synthetic scheme starting from glycerol. The molecular structure of the targeted molecules and synthesized intermediates in the synthetic scheme were confirmed by detailed structural analysis through 1 N-NMR, mass and IR spectroscopic techniques. Antibacterial activity was evaluated against the gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The derivatives also underwent docking analysis on the pdb's of enzymatic catalysts involved in the biosynthesis of lipid A using AutoDock Vina package. All synthesized fatty esters gave good antibacterial activity and binding energy upto -7 kcal/mol in the docking analysis. A structure-property relationship was established between alkyl chain lengths of diglycerides and their resultant binding energies. These molecules and their resultant activity can assist in further designing and retrosynthesis of molecular derivatives of drug molecules with lipid A biosynthesis as target for its inhibition.

Published
2023

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