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Resumen Introduccion La diarrea por Clostridium difficile constituye un importante problema de salud que parece incrementarse. En nuestro estudio analizamos los cambios en la incidencia de esta infeccion en los ultimos 11 anos. Material y metodos Estudio retrospectivo de los pacientes hospitalizados con diarrea por Clostridium difficile diagnosticados en el Hospital Universitario Marques de Valdecilla (Santander) desde el ano 2004 hasta el 2014. Resultados Se estudio a 244 pacientes (53% varones) de 66 (DE 15) anos. Los casos de adquisicion hospitalaria (80%) tenian, respecto a los de adquisicion comunitaria, mayor edad [67 (DE 15) vs. 63 (DE 19) anos; p = 0,01], comorbilidad alta (86% hospitalarios y 75% comunitarios; p = 0,01), uso de antibioticos (95 vs. 75%; p Clostridium difficile en los ultimos 11 anos. Conclusion El perfil clinico de los pacientes con diarrea por C lostridium difficile varia segun el lugar de adquisicion de la infeccion. Aumenta la prevalencia de esta enfermedad.

Introduction Clostridium difficile associated diarrhoea is a major health problem that seems to be on the increase. In our study, we analyse the changes in the incidence of this infection over the last 11 years. Methods A descriptive study in hospitalised patients with C. difficile associated diarrhoea in University Hospital Marques de Valdecilla (Santander, Spain) from 2004 to 2014. Results A total of 244 adults were identified [53% men; 66 (SD 15) years]. The cases of nosocomial acquisition (80%), with respect to community acquired C. difficile infection, were older [67 (SD 15) years vs. 63 (19) years; p = 0.01], high comorbidity (86% vs. 75%; p = 0.01), use of antibiotics (95% vs. 75%; p p C. difficile associated diarrhoea in our hospital over an 11-year period. Conclusion The clinical profile of patients with C. difficile diarrhoea varies by place of acquisition of infection. The prevalence of this disease is increasing.

Clostridium difficile associated diarrhoea is a major health problem that seems to be on the increase. In our study, we analyse the changes in the incidence of this infection over the last 11 years.A descriptive study in hospitalised patients with Clostridium difficile associated diarrhoea in University Hospital Marqués de Valdecilla (Santander, Spain) from 2004 to 2014.A total of 244 adults were identified [53% men; 66 (SD 15) years]. The cases of nosocomial acquisition (80%), with respect to community acquired Clostridium difficile infection, were older [67 (SD 15) years vs. 63 (19) years; P=.01), high comorbidity (86% vs. 75%; P=.01), use of antibiotics (95% vs. 75%; P.001) and proton pump inhibitors (87% vs. 48% P.001). There has been an increasing incidence of Clostridium difficile associated diarrhoea in our hospital over an 11-year period.The clinical profile of patients with Clostridium difficile diarrhoea varies by place of acquisition of infection. The prevalence of this disease is increasing.