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Your search keyword '"M S Bolhuis"' showing total 3 results
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3 results on '"M S Bolhuis"'

1. Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers.

Author

Y A de Reus, P Hagedoorn, M G G Sturkenboom, F Grasmeijer, M S Bolhuis, I Sibum, H A M Kerstjens, H W Frijlink, and O W Akkerman

Subjects
Medicine, Science
Abstract

RationaleInhaled antimicrobials enable high local concentrations where needed and, compared to orally administration, greatly reduce the potential for systemic side effects. In SARS-CoV-2 infections, hydroxychloroquine sulphate (HCQ) administered as dry powder via inhalation could be safer than oral HCQ allowing higher and therefore more effective pulmonary concentrations without dose limiting toxic effects.ObjectivesTo assess the local tolerability, safety and pharmacokinetic parameters of HCQ inhalations in single ascending doses of 5, 10 and 20 mg using the Cyclops dry powder inhaler.MethodsTwelve healthy volunteers were included in the study. Local tolerability and safety were assessed by pulmonary function tests, electrocardiogram and recording adverse events. To estimate systemic exposure, serum samples were collected before and 0.5, 2 and 3.5 h after inhalation.Results and discussionDry powder HCQ inhalations were well tolerated by the participants, except for transient bitter taste in all participants and minor coughing irritation. There was no significant change in QTc-interval or drop in FEV1 post inhalation. The serum HCQ concentration remained below 10 μg/L in all samples.ConclusionSingle doses of inhaled dry powder HCQ up to 20 mg are safe and well tolerated. Our data support that further studies with inhaled HCQ dry powder to evaluate pulmonary pharmacokinetics and efficacy are warranted.

Published
2022
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2. Bedaquiline exposure in people with drug-resistant TB treated for diabetes

Author

M. S. Bolhuis, O. W. Akkerman, M. G. G. Sturkenboom, J. F. M. van Boven, J-W. C. Alffenaar, J. Stevens, Microbes in Health and Disease (MHD), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), and Groningen Kidney Center (GKC)

Subjects
Pulmonary and Respiratory Medicine, Infectious Diseases, Diarylquinolines/therapeutic use, Antitubercular Agents/therapeutic use, Humans, Tuberculosis, Tuberculosis, Multidrug-Resistant/complications, Multidrug-Resistant/complications, Diabetes Complications/complications
Published
2023
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3. Clinical standards for drug-susceptible pulmonary TB

Author

O. W. Akkerman, R. Duarte, S. Tiberi, H. S. Schaaf, C. Lange, J. W. C. Alffenaar, J. Denholm, A. C. C. Carvalho, M. S. Bolhuis, S. Borisov, J. Bruchfeld, A. M. Cabibbe, J. A. Caminero, I. Carvalho, J. Chakaya, R. Centis, M. P. Dalcomo, L. D´Ambrosio, M. Dedicoat, K. Dheda, K. E. Dooley, J. Furin, J-M. García-García, N. A. H. van Hest, B. C. de Jong, X. Kurhasani, A. G. Märtson, S. Mpagama, M. Munoz Torrico, E. Nunes, C. W. M. Ong, D. J. Palmero, R. Ruslami, A. M. I. Saktiawati, C. Semuto, D. R. Silva, R. Singla, I. Solovic, S. Srivastava, J. E. M. de Steenwinkel, A. Story, M. G. G. Sturkenboom, M. Tadolini, Z. F. Udwadia, A. R. Verhage, J. P. Zellweger, G. B. Migliori, Medical Microbiology & Infectious Diseases, Akkerman, O W, Duarte, R, Tiberi, S, Schaaf, H S, Lange, C, Alffenaar, J W C, Denholm, J, Carvalho, A C C, Bolhuis, M S, Borisov, S, Bruchfeld, J, Cabibbe, A M, Caminero, J A, Carvalho, I, Chakaya, J, Centis, R, Dalcomo, M P, D Ambrosio, L, Dedicoat, M, Dheda, K, Dooley, K E, Furin, J, García-García, J-M, van Hest, N A H, de Jong, B C, Kurhasani, X, Märtson, A G, Mpagama, S, Torrico, M Munoz, Nunes, E, Ong, C W M, Palmero, D J, Ruslami, R, Saktiawati, A M I, Semuto, C, Silva, D R, Singla, R, Solovic, I, Srivastava, S, de Steenwinkel, J E M, Story, A, Sturkenboom, M G G, Tadolini, M, Udwadia, Z F, Verhage, A R, Zellweger, J P, Migliori, G B, and Microbes in Health and Disease (MHD)

Subjects
Pulmonary and Respiratory Medicine, Adult, education, treatment, rehabilitation, diagnosi, Infectious Diseases, SDG 3 - Good Health and Well-being, clinical standard, pulmonary TB, Humans, Child, Tuberculosis, Pulmonary, management, Human
Abstract

BACKGROUND: The aim of these clinical standards is to provide guidance on ‘best practice´ for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB).METHODS: A panel of 54 global experts in the field of TB care, public health, microbiology, and pharmacology were identified; 46 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all 46 participants.RESULTS: Seven clinical standards were defined: Standard 1, all patients (adult or child) who have symptoms and signs compatible with PTB should undergo investigations to reach a diagnosis; Standard 2, adequate bacteriological tests should be conducted to exclude drug-resistant TB; Standard 3, an appropriate regimen recommended by WHO and national guidelines for the treatment of PTB should be identified; Standard 4, health education and counselling should be provided for each patient starting treatment; Standard 5, treatment monitoring should be conducted to assess adherence, follow patient progress, identify and manage adverse events, and detect development of resistance; Standard 6, a recommended series of patient examinations should be performed at the end of treatment; Standard 7, necessary public health actions should be conducted for each patient. We also identified priorities for future research into PTB.CONCLUSION: These consensus-based clinical standards will help to improve patient care by guiding clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment for PTB.

Published
2022
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