33 results on '"M., Catanesi"'
Search Results
2. Measurement of the inclusive $\nu_{\mu}$ charged current cross section on iron and hydrocarbon in the T2K on-axis neutrino beam
- Author
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P. de Perio, Yoshikazu Yamada, E. Larkin, D. Brailsford, M. J. Wilking, R. Poutissou, K. Mavrokoridis, F. d. M. Blaszczyk, Y. Kanazawa, J. D. Perkin, Hidekazu Kakuno, I. Kreslo, T. Sekiguchi, L. Ludovici, A. T. Suzuki, M. Ravonel, S. Martynenko, J. Lagoda, S. R. Dennis, A. Bravar, J. Steinmann, Y. Takeuchi, A. Cervera, V. Palladino, M. Kabirnezhad, T. Akiri, T. Hasegawa, G. Christodoulou, M. Sorel, J. F. Martin, D. Autiero, A. Redij, A. Thorley, A. Korzenev, K. Sakashita, S. M. Oser, C. Bojechko, R. J. Wilson, P. Jonsson, R. Ohta, D. Ruterbories, M. Ieva, Yasunari Suzuki, T. Nakadaira, C. K. Jung, Y. Seiya, W. R. Kropp, Minoru Otani, F. Sato, R. Castillo, Yuichi Oyama, R. P. Litchfield, M. Barbi, Hidetoshi Kubo, J. R. Wilson, C. Nielsen, S. Tobayama, K. Nakamura, A. K. Ichikawa, M. D. Haigh, Scott Davis, D. Hansen, I. Lamont, F. Bay, Masato Shiozawa, Antonin Vacheret, L. L. Kormos, S. Assylbekov, S. Moriyama, Masayuki Nakahata, D. R. Hadley, J. Zmuda, A. C. Weber, S. Roth, J. Kameda, S. Horikawa, T. Wachala, B. E. Berger, P. Sinclair, P. A. Rodrigues, M. Tzanov, Rhiju Das, B. Jamieson, C. J. Metelko, E. S. Pinzon Guerra, Hiroaki Aihara, Koji Yamamoto, P. N. Ratoff, T. Kutter, Th. A. Mueller, Y. Uchida, A. Hillairet, A. Longhin, J. Marteau, Z. Williamson, A. Haesler, K. S. McFarland, F. Sanchez, R. Tacik, O. Perevozchikov, Matthew T. Reeves, Takahiro Hiraki, C. Lister, N. Grant, S. Short, N. C. Hastings, P. Plonski, P. Mijakowski, M. Friend, Teppei Katori, V. Galymov, G. Collazuol, Mark Scott, T. Maruyama, A. Kilinski, S. Bhadra, Stefan Schoppmann, J. Caravaca Rodríguez, H.A. Tanaka, L. Zambelli, E. Radicioni, J. L. Palomino, Michal Dziewiecki, L. Southwell, J. Myslik, T. Duboyski, K. Gilje, S. Murphy, Masashi Tanaka, C. W. Walter, J. H. Jo, Artur F. Izmaylov, Seiko Hirota, A. P. Furmanski, T. Kikawa, M. Gonin, K. Zaremba, L. Escudero, H. M. O'Keeffe, Kazuhiro Suzuki, V. Paolone, T. Golan, D. Kielczewska, M. Batkiewicz, G.D. Barr, K. Abe, C. Pistillo, W. Oryszczak, André Rubbia, K. Huang, A. Jacob, Yuki Fujii, E. Mazzucato, B. A. Popov, A. Dabrowska, T. Dealtry, K. Ieki, D. Karlen, A. Missert, K. Iyogi, L. F. Thompson, E. D. Zimmerman, Jan Kisiel, M. Yu, D. L. Wark, J. M. Poutissou, C. Bronner, Atsushi Takeda, P. Kitching, M. O. Wascko, J. Adam, D. Cherdack, A. Clifton, Yusuke Koshio, B. Smith, E. Reinherz-Aronis, T. Okusawa, J. Holeczek, S. B. Boyd, K. Nakayoshi, N. Buchanan, F. Retiere, M. Murdoch, Jungsang Kim, S. Y. Suzuki, Takaaki Kajita, Y. Shustrov, K. Iwamoto, A. Zalewska, I. Karpikov, R. J. Wilkes, Hiroyuki Sekiya, T. Szeglowski, R. Sacco, S. Nakayama, D. Goeldi, E. Scantamburlo, Kate Scholberg, D. Dewhurst, T. Kobayashi, Yukika Nishimura, S. Di Luise, L. Cremonesi, A. V. Waldron, C. McGrew, A. N. Khotjantsev, S. Yen, L. Koch, T. Yano, R. L. Helmer, M. Ikeda, M. Bass, A. C. Kaboth, J. Dumarchez, J. Schwehr, R.P. Kurjata, S. J. Coleman, T. Tomura, M. Hartz, H. K. Tanaka, Y. Hayato, C. Wilkinson, P. Stamoulis, Joshua Hignight, Y. Fukuda, M. Posiadala, M. G. Catanesi, Kendall Mahn, C. Andreopoulos, T. Lindner, A. J. Finch, R. A. Johnson, E. Kearns, S. Berkman, C. Touramanis, Antonio Ereditato, D. Sgalaberna, O. V. Mineev, Masashi Yokoyama, E. Poplawska, C. Yanagisawa, Y. Totsuka, M. Zito, I. Z. Danko, A. Konaka, M. M. Khabibullin, R. A. Wendell, Susumu Takahashi, Vincenzo Berardi, N. Yershov, M. A.M. Rayner, T. Tsukamoto, T. Hara, M. B. Smy, A. D. Marino, Y. Petrov, E. Rondio, W. H. Toki, O. Drapier, T. Wongjirad, S. Emery-Schrenk, A. Blondel, S. A. Dytman, G. De Rosa, R. A. Owen, Gareth J. Barker, N. McCauley, M. Hierholzer, F. Di Lodovico, M. McCarthy, B. Still, M. Tada, Yusuke Suda, D. J. Payne, R. Terri, K. E. Duffy, G. Vasseur, Tsuyoshi Nakaya, J. Imber, T. Ishida, M. Miura, A. Himmel, A. Kolaceke, T. Yuan, R. G. Calland, T. Ishii, D. Gudin, M. Lazos, S. Manly, P. Hamilton, M. Nirkko, P. Przewlocki, S. Bordoni, S. L. Cartwright, L. Magaletti, C. Giganti, K. Connolly, E. Iwai, D. Terhorst, M. R. Vagins, A. Murakami, Yu. Kudenko, K. Nishikawa, Jan T. Sobczyk, K. Laihem, T. J. Irvine, K. Koseki, M. Lawe, H. W. Sobel, P. Rojas, C. A. Miller, A. Minamino, C. Hearty, M. Ziembicki, J. Zalipska, J. Insler, B. Quilain, Marco Laveder, J. P. Coleman, C. Densham, M. Malek, Akitaka Ariga, Ko Okumura, Shigeki Aoki, L. Pickard, S. Giffin, V. Matveev, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), T2K, K. a., Abe, J., Adam, H. a., Aihara, T., Akiri, C., Andreopoulo, S., Aoki, A., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, V., Berardi, B. w., Berger, S., Berkman, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Bordoni, S., Boyd, D., Brailsford, A., Bravar, C., Bronner, N., Buchanan, R., Calland, J. C., Rodr??????guez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, L., Cremonesi, A., Dabrowska, I., Danko, R., Da, S., Davi, P. D., Perio, DE ROSA, Gianfranca, T. a., Dealtry, S. b., Denni, C., Densham, D., Dewhurst, F. D., Lodovico, S. D., Luise, O., Drapier, T., Duboyski, K., Duffy, J., Dumarchez, S., Dytman, M., Dziewiecki, S., Emery Schrenk, A., Ereditato, L., Escudero, A., Finch, M., Friend, Y., Fujii, Y., Fukuda, A., Furmanski, V., Galymov, S., Giffin, C., Giganti, K., Gilje, D., Goeldi, T., Golan, M., Gonin, N., Grant, D., Gudin, D., Hadley, A., Haesler, M., Haigh, P., Hamilton, D., Hansen, T., Hara, M. a., Hartz, T., Hasegawa, N., Hasting, Y. a., Hayato, C., Hearty, R., Helmer, M., Hierholzer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, S., Hirota, J., Holeczek, S., Horikawa, K., Huang, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Irvine, T., Ishida, T., Ishii, E., Iwai, K., Iwamoto, K., Iyogi, A. v., Izmaylov, A., Jacob, B., Jamieson, R., Johnson, J., Jo, P., Jonsson, C., Jung, M., Kabirnezhad, A., Kaboth, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D. a., Karlen, I., Karpikov, T., Katori, E. w., Kearn, M., Khabibullin, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, J., Kisiel, P., Kitching, T., Kobayashi, L., Koch, A., Kolaceke, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, I., Lamont, E., Larkin, M., Laveder, M., Lawe, M., Lazo, T., Lindner, C., Lister, R., Litchfield, A., Longhin, L., Ludovici, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marino, J., Marteau, J., Martin, S., Martynenko, T., Maruyama, V., Matveev, K., Mavrokoridi, E., Mazzucato, M., Mccarthy, N., Mccauley, K., Mcfarland, C., Mcgrew, C., Metelko, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, A., Missert, M., Miura, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nakadaira, M. a., Nakahata, K. w., Nakamura, S., Nakayama, T. y., Nakaya, K., Nakayoshi, C., Nielsen, M., Nirkko, K., Nishikawa, Y., Nishimura, H., O'Keeffe, R., Ohta, K. a., Okumura, T., Okusawa, W., Oryszczak, S., Oser, M., Otani, R., Owen, Y., Oyama, Palladino, Vittorio, J., Palomino, V., Paolone, D., Payne, O., Perevozchikov, J., Perkin, Y., Petrov, L., Pickard, E. P., Guerra, C., Pistillo, P., Plonski, E., Poplawska, B., Popov, M., Posiadala, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, A., Redij, M., Reeve, E., Reinherz Aroni, F., Retiere, P., Rodrigue, P., Roja, E., Rondio, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., S??????nchez, F., Sato, E., Scantamburlo, K., Scholberg, S., Schoppmann, J., Schwehr, M., Scott, Y., Seiya, T., Sekiguchi, H., Sekiya, D., Sgalaberna, M. a., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, M., Smy, J., Sobczyk, H. w., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, Y., Suda, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, R. a., Tacik, M., Tada, S., Takahashi, A., Takeda, Y. x., Takeuchi, H., Tanaka, M., Tanaka, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, A., Vacheret, M. w., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, D. a., Wark, M., Wascko, A. a., Weber, R., Wendell, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, T., Yano, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, M., Yu, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, J., Zmuda, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Science and Technology Facilities Council (STFC)
- Subjects
Particle physics ,Nuclear and High Energy Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,FOS: Physical sciences ,Astronomy & Astrophysics ,7. Clean energy ,01 natural sciences ,Physics, Particles & Fields ,High Energy Physics - Experiment ,Nuclear physics ,Cross section (physics) ,Physics and Astronomy (all) ,High Energy Physics - Experiment (hep-ex) ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,010306 general physics ,Neutrino oscillation ,Nuclear Experiment ,DETECTOR ,Charged current ,Mathematical Physics ,chemistry.chemical_classification ,Physics ,Science & Technology ,hep-ex ,010308 nuclear & particles physics ,T2K experiment ,Física ,Hydrocarbon ,chemistry ,Physical Sciences ,High Energy Physics::Experiment ,Neutrino ,Nucleon - Abstract
We report a measurement of the $\nu_\mu$ inclusive charged current cross sections on iron and hydrocarbon in the T2K on-axis neutrino beam. The measured inclusive charged current cross sections on iron and hydrocarbon averaged over the T2K on-axis flux with a mean neutrino energy of 1.51 GeV are $(1.444\pm0.002(stat.)_{-0.157}^{+0.189}(syst.))\times 10^{-38}\mathrm{cm}^2/\mathrm{nucleon}$, and $(1.379\pm0.009(stat.)_{-0.147}^{+0.178}(syst.))\times 10^{-38}\mathrm{cm}^2/\mathrm{nucleon}$, respectively, and their cross section ratio is $1.047\pm0.007(stat.)\pm0.035(syst.)$. These results agree well with the predictions of the neutrino interaction model, and thus we checked the correct treatment of the nuclear effect for iron and hydrocarbon targets in the model within the measurement precisions., Comment: 15 pages, 17 figures
- Published
- 2014
3. Observation of Electron Neutrino Appearance in a Muon Neutrino Beam
- Author
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Y. Yamada, E. Rondio, N. McCauley, K. Huang, M. Bass, S. L. Cartwright, K. Connolly, J. Kameda, P. Przewlocki, M. J. Wilking, J. Zmuda, L. L. Kormos, D. Brailsford, R. Ohta, André Rubbia, R. Poutissou, S. Takahashi, D. Terhorst, Lester D.R. Thompson, K. Zaremba, F. Sato, R. Castillo, Yuichi Oyama, J. Kisiel, Berardi, R. P. Litchfield, F. Di Lodovico, C. Hearty, A. Izmaylov, J. Steinmann, Atsushi Takeda, A. Kilinski, C. W. Walter, K. Gilje, A. V. Waldron, T. Nagasaki, Alexander Finch, A. Clifton, T. Dealtry, A. Missert, A. Redij, S. Assylbekov, A. Longhin, L. Ludovici, J. Caravaca Rodríguez, Yu. G. Kudenko, J. Marteau, P. A. Rodrigues, M. Lawe, R. J. Smith, Z. Williamson, A. Kolaceke, H.A. Tanaka, P. Rojas, K. Nakayoshi, L. Monfregola, Kimihiro Okumura, P. Hamilton, S. Tobayama, Frédéric Dufour, T. Okusawa, Joshua Hignight, Yoshihiro Suzuki, S. Murphy, C. Licciardi, M. Ikeda, A. C. Kaboth, Y. Fukuda, Y. Totsuka, I. Lamont, D. Autiero, R. A. Johnson, M. Miura, L. Magaletti, C. Giganti, F. Retiere, M. A.M. Rayner, T. Wachala, B. Quilain, Dennis, T. Wongjirad, M. Vagins, S. Horikawa, T. Akiri, S. Berkman, A. C. Weber, Robert Wilson, J. M. Poutissou, C. Bronner, K. Mavrokoridis, J. Adam, J. Lagoda, Sy Suzuki, F. d. M. Blaszczyk, M. Murdoch, Hiroyuki Sekiya, T. Szeglowski, S. Yen, C. Bojechko, R. L. Helmer, Kendall Mahn, S. Kumaratunga, Yusuke Koshio, Galymov, M. Ravonel, Marco Laveder, D. Cherdack, K. Abe, R. Sacco, C. McGrew, Y. Kanazawa, B. Still, Masashi Tanaka, A. P. Furmanski, P. Stamoulis, A. Gaudin, L. Koch, T. Sekiguchi, A. Hillairet, Y. Petrov, Ken Sakashita, C. Andreopoulos, A. Zalewska, K. Nishikawa, G. Christodoulou, D. Naples, T. Hara, A. Jacob, S. Manly, Antonin Vacheret, W. R. Kropp, T. Hasegawa, S. Mine, C. K. Jung, W. Toki, G. De Rosa, J. Holeczek, S. Nakayama, K. E. Duffy, Iain Alexander Bertram, S. W. K. Emery, K. Koseki, K. Iyogi, R. A. Owen, D. Kielczewska, M. Batkiewicz, J. F. Martin, M. Tzanov, M. Ieva, Jan T. Sobczyk, C. J. Metelko, S. M. Oser, A. Dabrowska, S. Dytman, M. Barbi, N. Grant, J. Imber, S. Moriyama, S. Short, N. C. Hastings, G. Collazuol, E. D. Zimmerman, J.J. Gómez-Cadenas, E. Mazzucato, H. Kubo, G. F. Pearce, Y. Seiya, M. Macaire, Masayuki Nakahata, A. Konaka, F. Bay, M. Posiadala, Y. Uchida, M. B. Smy, M. G. Catanesi, P. Plonski, R. Tacik, J. D. Perkin, Mark Scott, Oleg Mineev, J. Schwehr, O. Perevozchikov, Hajime Tanaka, M. Gonin, Takahiro Hiraki, C. Pistillo, L. Escudero, P. de Perio, S. Bordoni, D. Goeldi, S. Di Luise, L. Cremonesi, Hadley, T. Yuan, Palladino, T. J. Irvine, M. Ziembicki, J. Zalipska, J. Insler, K. Laihem, Y. Suda, Henry W. Sobel, T. Lindner, W. Oryszczak, D. Sgalaberna, C. Densham, M. Sorel, B. Smith, O. Drapier, M. Nirkko, E. Reinherz-Aronis, Michal Dziewiecki, Kazuhiro Yamamoto, R. A. Wendell, Y. Nishimura, Takaaki Kajita, Matveev, K. Ueno, A. K. Ichikawa, Tomoko Ariga, Y. Shustrov, S. Hirota, B. E. Berger, S. Roth, M. Mezzetto, A. Cervera, Federico Sanchez, G. Vasseur, E. S. Pinzon Guerra, Th. A. Mueller, M. Zito, Matthew T. Reeves, J. Marzec, Paolone, D. Payne, H. Kakuno, I. Kreslo, C. Nielsen, H. M. O'Keeffe, E. Scantamburlo, P. Kitching, M. O. Wascko, E. Kearns, C. Lister, R.P. Kurjata, S. W. Bentham, Akitaka Ariga, T. Tsukamoto, L. Zambelli, B. A. Popov, Shigeki Aoki, T. Maruyama, L. Pickard, R. Terri, S. Giffin, Wilson, Kate Scholberg, T. Nakadaira, J. H. Jo, A. Murakami, M. Hartz, I. Z. Danko, A. Thorley, A. Korzenev, G.D. Barr, A. Minamino, M. Malek, Rhiju Das, B. Jamieson, K. P. Lee, I. Karpikov, S. J. Coleman, L. Southwell, J. Myslik, C. Touramanis, Antonio Ereditato, N. Yershov, T. Golan, Kevin Scott McFarland, T. Kikawa, Takashi Kobayashi, J. Dumarchez, L. Floetotto, Scott Davis, D. Hansen, S. J. Ives, C. A. Miller, T. Tomura, E. L. Mathie, S. B. Boyd, T. Ishii, M. M. Khabibullin, K. Suzuki, M. McCarthy, Y. Takeuchi, T. Ishida, D. Ruterbories, Hiroaki Aihara, P. N. Ratoff, T. Kutter, Koji Nakamura, A. N. Khotjantsev, Y. Fujii, A. Suzuki, Masashi Yokoyama, E. Poplawska, Tsuyoshi Nakaya, M. Friend, A. Bravar, Masato Shiozawa, M. Tada, A. Haesler, P. Jonsson, S. Bhadra, P. Sinclair, Arnaud Robert, P. Mijakowski, Jy Kim, A. Himmel, E. Radicioni, R. G. Calland, D. Gudin, M. Lazos, D. L. Wark, A. D. Marino, A. Blondel, N. J. Buchanan, K. Ieki, D. Karlen, R. J. Wilkes, C. Wilkinson, C. Yanagisawa, Gareth J. Barker, M. Hierholzer, J. P. Coleman, Yoshinari Hayato, Haigh, T. Duboyski, T. Nakai, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, T2K, K., Abe, J., Adam, H., Aihara, T., Akiri, C., Andreopoulo, S., Aoki, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, S., Bentham, V., Berardi, B., Berger, S., Berkman, I., Bertram, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Bordoni, S., Boyd, D., Brailsford, A., Bravar, C., Bronner, N., Buchanan, R., Calland, J. C., Rodr??????guez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, L., Cremonesi, A., Dabrowska, I., Danko, R., Da, S., Davi, P. D., Perio, DE ROSA, Gianfranca, T., Dealtry, S., Denni, C., Densham, F. D., Lodovico, S. D., Luise, O., Drapier, T., Duboyski, K., Duffy, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, S., Emery, A., Ereditato, L., Escudero, A., Finch, L., Floetotto, M., Friend, Y., Fujii, Y., Fukuda, A., Furmanski, V., Galymov, A., Gaudin, S., Giffin, C., Giganti, K., Gilje, D., Goeldi, T., Golan, J., Gomez Cadena, M., Gonin, N., Grant, D., Gudin, D., Hadley, A., Haesler, M., Haigh, P., Hamilton, D., Hansen, T., Hara, M., Hartz, T., Hasegawa, N., Hasting, Y., Hayato, C., Hearty, R., Helmer, M., Hierholzer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, S., Hirota, J., Holeczek, S., Horikawa, K., Huang, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Irvine, T., Ishida, T., Ishii, S., Ive, K., Iyogi, A., Izmaylov, A., Jacob, B., Jamieson, R., Johnson, J., Jo, P., Jonsson, C., Jung, A., Kaboth, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D., Karlen, I., Karpikov, E., Kearn, M., Khabibullin, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, J., Kisiel, P., Kitching, T., Kobayashi, L., Koch, A., Kolaceke, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, S., Kumaratunga, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, I., Lamont, M., Laveder, M., Lawe, M., Lazo, K., Lee, C., Licciardi, T., Lindner, C., Lister, R., Litchfield, A., Longhin, L., Ludovici, M., Macaire, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marino, J., Marteau, J., Martin, T., Maruyama, J., Marzec, E., Mathie, V., Matveev, K., Mavrokoridi, E., Mazzucato, M., Mccarthy, N., Mccauley, K., Mcfarland, C., Mcgrew, C., Metelko, M., Mezzetto, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, M., Miura, L., Monfregola, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nagasaki, T., Nakadaira, M., Nakahata, T., Nakai, K., Nakamura, S., Nakayama, T., Nakaya, K., Nakayoshi, D., Naple, C., Nielsen, M., Nirkko, K., Nishikawa, Y., Nishimura, H., O'Keeffe, R., Ohta, K., Okumura, T., Okusawa, W., Oryszczak, S., Oser, R., Owen, Y., Oyama, Palladino, Vittorio, V., Paolone, D., Payne, G., Pearce, O., Perevozchikov, J., Perkin, Y., Petrov, L., Pickard, E. P., Guerra, C., Pistillo, P., Plonski, E., Poplawska, B., Popov, M., Posiadala, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, A., Redij, M., Reeve, E., Reinherz Aroni, F., Retiere, A., Robert, P., Rodrigue, P., Roja, E., Rondio, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., S??????nchez, F., Sato, E., Scantamburlo, K., Scholberg, J., Schwehr, M., Scott, Y., Seiya, T., Sekiguchi, H., Sekiya, D., Sgalaberna, M., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, R., Smith, M., Smy, J., Sobczyk, H., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, Y., Suda, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, R., Tacik, M., Tada, S., Takahashi, A., Takeda, Y., Takeuchi, H., Tanaka, M., Tanaka, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, D., Wark, M., Wascko, A., Weber, R., Wendell, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, Muda, J. ?. ?. ?., Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Science and Technology Facilities Council (STFC)
- Subjects
General Physics ,Particle physics ,Solar neutrino ,Physics, Multidisciplinary ,FOS: Physical sciences ,General Physics and Astronomy ,7. Clean energy ,09 Engineering ,High Energy Physics - Experiment ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Tau neutrino ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Neutrino oscillation ,01 Mathematical Sciences ,Physics ,Science & Technology ,02 Physical Sciences ,hep-ex ,High Energy Physics::Phenomenology ,T2K experiment ,Física ,Solar neutrino problem ,Neutrino detector ,T2K Collaboration ,Physical Sciences ,Measurements of neutrino speed ,High Energy Physics::Experiment ,Neutrino - Abstract
The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3$\sigma$ when compared to 4.92 $\pm$ 0.55 expected background events. In the PMNS mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles $\theta_{12}$, $\theta_{23}$, $\theta_{13}$, a mass difference $\Delta m^2_{32}$ and a CP violating phase $\delta_{\mathrm{CP}}$. In this neutrino oscillation scenario, assuming $|\Delta m^2_{32}| = 2.4 \times 10^{-3}$ $\rm eV^2$, $\sin^2 \theta_{23} = 0.5$, and $\Delta m^2_{32} >0$ ($\Delta m^2_{32}, Comment: 8 pages, 6 figures
- Published
- 2014
4. Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear deexcitation gamma rays
- Author
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J. Caravaca Rodríguez, H.A. Tanaka, R. Poutissou, J. Holeczek, K. Nakayoshi, N. Buchanan, A. C. Weber, R. L. Helmer, M. Yu, S. Kumaratunga, A. Redij, J. M. Poutissou, C. Bronner, Yukika Nishimura, J. Zmuda, S. J. Coleman, T. J. Irvine, M. Posiadala-Zezula, N. Grant, C. Touramanis, Antonio Ereditato, L. Southwell, J. Myslik, T. Sekiguchi, L. Ludovici, G. Collazuol, Mark Scott, N. Yershov, T. Golan, K. Suzuki, Y. Takeuchi, M. Sorel, André Rubbia, T. Ovsyannikova, S. Murphy, A. K. Ichikawa, S. Roth, J. Kameda, E. S. Pinzon Guerra, Th. A. Mueller, Matthew T. Reeves, P. Mijakowski, H. M. O'Keeffe, F. Di Lodovico, P. Kitching, M. O. Wascko, T. Maruyama, Yuki Fujii, Takaaki Kajita, Y. Shustrov, M. Ieva, C. Yanagisawa, M. M. Khabibullin, K. Zaremba, A. V. Waldron, T. Nagasaki, J. H. Jo, C. Nantais, G.D. Barr, F. Retiere, T. Nakai, M. Tada, Yu. G. Kudenko, L. Monfregola, S. Manly, P. Hamilton, B. A. Popov, C. A. Miller, O. Drapier, M. McCarthy, M. D. Haigh, I. Lamont, K. Iwamoto, A. Clifton, A. Minamino, A. T. Suzuki, A. Zalewska, L. Magaletti, C. Giganti, F. Sato, R. Castillo, Yuichi Oyama, J. Dumarchez, J. Schwehr, Takahiro Hiraki, I. Karpikov, Gareth J. Barker, M. Hierholzer, K. Huang, Atsushi Takeda, R. P. Litchfield, E. Rondio, N. McCauley, Hiroaki Aihara, M. Ravonel, P. Stamoulis, J. A. Nowak, E. Iwai, J. F. Martin, Kate Scholberg, T. Akiri, S. Assylbekov, P. N. Ratoff, T. Kutter, D. Autiero, T. Nakadaira, R. A. Johnson, Joshua Hignight, Anne Robert, Yoshihiro Suzuki, A. Konaka, Koji Yamamoto, T. Tsukamoto, P. Przewlocki, C. Pistillo, T. Hasegawa, O. V. Mineev, A. Gaudin, M. Hartz, B. Smith, E. Reinherz-Aronis, H. K. Tanaka, D. Payne, J. Adam, M. Friend, Teppei Katori, Yusuke Koshio, Lester D.R. Thompson, R. A. Wendell, C. W. Walter, S. Martynenko, E. Scantamburlo, Scott Davis, D. Hansen, A. Himmel, Y. Totsuka, J. Lagoda, T. Ishida, G. Christodoulou, Susumu Takahashi, M. A.M. Rayner, Leïla Haegel, C. Bojechko, Richard J.H. Smith, A. Kolaceke, M. R. Vagins, R.P. Kurjata, S. W. Bentham, P. Rojas, R. Terri, M. Barbi, V. Galymov, M. Mezzetto, S. Berkman, M. Zito, Hidekazu Kakuno, R. J. Wilson, S. Mine, Vincenzo Berardi, J. P. Coleman, I. Kreslo, S. J. Ives, R. Ohta, S. R. Johnson, D. Ruterbories, T. Wongjirad, D. Cherdack, M. Malek, I. Z. Danko, R. G. Calland, D. Gudin, G. De Rosa, M. B. Smy, K. Abe, R. Sacco, M. Lazos, A. Thorley, A. Korzenev, F. Shaker, S. A. Dytman, Koh Ueno, Y. Petrov, K. Sakashita, A. Murakami, Jan Kisiel, R. A. Owen, S. Moriyama, F. Bay, J. Marzec, Hidetoshi Kubo, A. N. Khotjantsev, D. Goeldi, S. Bordoni, T. Tomura, D. Naples, S. M. Oser, A. Hillairet, S. Short, N. C. Hastings, P. Plonski, C. McGrew, Tomoko Ariga, L. Koch, J.J. Gómez-Cadenas, T. Kobayashi, S. Di Luise, L. Cremonesi, M. Macaire, J. L. Palomino, Hiroyuki Sekiya, Rhiju Das, E. Mazzucato, Antonin Vacheret, C. Hearty, Y. Hayato, C. Andreopoulos, T. Szeglowski, B. Jamieson, E. L. Mathie, Masayuki Nakahata, M. Lawe, Y. Seiya, Y. Uchida, G. F. Pearce, P. de Perio, R. Tacik, O. Perevozchikov, Yoshikazu Yamada, Artur F. Izmaylov, M. Miura, K. P. Lee, Y. Fukuda, M. Tzanov, M. Ziembicki, C. J. Metelko, H. W. Sobel, T. Ishii, K. Ieki, J. Zalipska, J. Insler, Kendall Mahn, A. Longhin, J. Marteau, S. B. Boyd, Z. Williamson, Michal Dziewiecki, Yusuke Suda, C. Licciardi, D. Karlen, R. J. Wilkes, T. Yuan, K. E. Duffy, Iain Alexander Bertram, I. Taylor, C. K. Jung, D. Dewhurst, G. Vasseur, M. G. Catanesi, A. Cervera, V. Palladino, M. Kabirnezhad, J. Imber, B. Quilain, B. Still, Masato Shiozawa, C. Wilkinson, Marco Laveder, A. Haesler, D. Sgalaberna, S. Bhadra, S. L. Cartwright, K. Connolly, Seiko Hirota, T. Kikawa, M. Gonin, L. Escudero, K. Mavrokoridis, F. d. M. Blaszczyk, Stefan Schoppmann, A. Kilinski, Akitaka Ariga, Y. Kanazawa, Ko Okumura, W. Oryszczak, P. A. Rodrigues, D. Terhorst, E. Kearns, T. Okusawa, Jungsang Kim, Masashi Yokoyama, E. Poplawska, J. R. Wilson, C. Nielsen, S. Y. Suzuki, M. Ikeda, T. Duboyski, M. Bass, A. C. Kaboth, A. Mefodiev, Tsuyoshi Nakaya, Shigeki Aoki, L. Pickard, S. Giffin, C. Lister, V. Matveev, A. Blondel, K. Nishikawa, Jan T. Sobczyk, K. Laihem, Masashi Tanaka, A. P. Furmanski, K. Koseki, V. Paolone, A. Jacob, K. Iyogi, E. D. Zimmerman, E. Radicioni, D. L. Wark, G. A. Fiorentini Aguirre, T. Hara, A. D. Marino, S. R. Dennis, A. Bravar, P. Jonsson, D. Kielczewska, M. Batkiewicz, P. Sinclair, A. Dabrowska, T. Lindner, C. Densham, S. King, W. R. Kropp, S. Tobayama, K. Nakamura, D. R. Hadley, S. Horikawa, T. Wachala, F. Sanchez, E. Larkin, M. J. Wilking, J. Steinmann, W. H. Toki, B. E. Berger, L. Zambelli, Alexander Finch, C. Riccio, T. Dealtry, A. Missert, L. L. Kormos, F. Dufour, K. S. McFarland, K. Gilje, J. D. Perkin, M. Nirkko, M. Murdoch, S. Nakayama, S. Yen, T. Yano, S. Emery-Schrenk, D. Brailsford, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), T2K, K., Abe, J., Adam, H. a., Aihara, T., Akiri, C., Andreopoulo, S., Aoki, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, S., Bentham, V., Berardi, B. w., Berger, S., Berkman, I., Bertram, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Bordoni, S., Boyd, D., Brailsford, A., Bravar, C., Bronner, N., Buchanan, R., Calland, J. C., Rodr??????guez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, L., Cremonesi, A., Dabrowska, I., Danko, R., Da, S., Davi, P. D., Perio, DE ROSA, Gianfranca, T. a., Dealtry, S. b., Denni, C., Densham, D., Dewhurst, F. D., Lodovico, S. D., Luise, O., Drapier, T., Duboyski, K., Duffy, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, S., Emery Schrenk, A., Ereditato, L., Escudero, A., Finch, G. F., Aguirre, M., Friend, Y., Fujii, Y., Fukuda, A., Furmanski, V., Galymov, A., Gaudin, S., Giffin, C., Giganti, K., Gilje, D., Goeldi, T., Golan, J., Gomez Cadena, M., Gonin, N., Grant, D., Gudin, D., Hadley, L., Haegel, A., Haesler, M., Haigh, P., Hamilton, D., Hansen, T., Hara, M. a., Hartz, T., Hasegawa, N., Hasting, Y. a., Hayato, C., Hearty, R., Helmer, M., Hierholzer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, S., Hirota, J., Holeczek, S., Horikawa, K., Huang, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Irvine, T., Ishida, T., Ishii, S., Ive, E., Iwai, K., Iwamoto, K., Iyogi, A. v., Izmaylov, A., Jacob, B., Jamieson, R., Johnson, S., Johnson, J., Jo, P., Jonsson, C., Jung, M., Kabirnezhad, A., Kaboth, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D. a., Karlen, I., Karpikov, T., Katori, E. w., Kearn, M., Khabibullin, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, S., King, J., Kisiel, P., Kitching, T., Kobayashi, L., Koch, A., Kolaceke, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, S., Kumaratunga, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, I., Lamont, E., Larkin, M., Laveder, M., Lawe, M., Lazo, K., Lee, C., Licciardi, T., Lindner, C., Lister, R., Litchfield, A., Longhin, L., Ludovici, M., Macaire, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marino, J., Marteau, J., Martin, S., Martynenko, T., Maruyama, J., Marzec, E., Mathie, V., Matveev, K., Mavrokoridi, E., Mazzucato, M., Mccarthy, N., Mccauley, K., Mcfarland, C., Mcgrew, A., Mefodiev, C., Metelko, M., Mezzetto, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, M., Miura, L., Monfregola, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nagasaki, T., Nakadaira, M. a., Nakahata, T., Nakai, K. w., Nakamura, S., Nakayama, T. y., Nakaya, K., Nakayoshi, C., Nantai, D., Naple, C., Nielsen, M., Nirkko, K., Nishikawa, Y., Nishimura, J., Nowak, H., O'Keeffe, R., Ohta, K. a., Okumura, T., Okusawa, W., Oryszczak, S., Oser, T., Ovsyannikova, R., Owen, Y., Oyama, Palladino, Vittorio, J., Palomino, V., Paolone, D., Payne, G., Pearce, O., Perevozchikov, J., Perkin, Y., Petrov, L., Pickard, E. P., Guerra, C., Pistillo, P., Plonski, E., Poplawska, B., Popov, M., Posiadala Zezula, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, A., Redij, M., Reeve, E., Reinherz Aroni, Riccio, Ciro, F., Retiere, A., Robert, P., Rodrigue, P., Roja, E., Rondio, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., S??????nchez, F., Sato, E., Scantamburlo, K., Scholberg, S., Schoppmann, J., Schwehr, M., Scott, Y., Seiya, T., Sekiguchi, H. a., Sekiya, D., Sgalaberna, F., Shaker, M. a., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, R., Smith, M., Smy, J., Sobczyk, H. w., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, Y., Suda, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, R. a., Tacik, M., Tada, S., Takahashi, A., Takeda, Y. x., Takeuchi, H., Tanaka, M., Tanaka, I., Taylor, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M. w., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, D. a., Wark, M., Wascko, A. a., Weber, R., Wendell, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, T., Yano, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, M., Yu, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, J., Zmuda, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)
- Subjects
Nuclear and High Energy Physics ,Cherenkov detector ,Physics::Instrumentation and Detectors ,C-12 ,FOS: Physical sciences ,Astronomy & Astrophysics ,law.invention ,High Energy Physics - Experiment ,Physics, Particles & Fields ,Nuclear physics ,SUPER-KAMIOKANDE DETECTOR ,Cross section (physics) ,High Energy Physics - Experiment (hep-ex) ,law ,EXCITATION ,ABSORPTION ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,SCATTERING ,O-16 ,Nuclear Experiment ,Physics ,CALIBRATION ,Science & Technology ,Neutral current ,hep-ex ,Gamma ray ,T2K experiment ,Física ,3. Good health ,Physical Sciences ,Neutrino ,WEAK ,Fiducial marker ,Beam (structure) - Abstract
We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation $\gamma$-rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to $3.01 \times 10^{20}$ protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the $4-30$ MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background is primarily nonquasielastic neutral-current interactions and has only 1.2 events from natural radioactivity. The flux-averaged NCQE cross section we measure is $1.55 \times 10^{-38}$ cm$^2$ with a 68\% confidence interval of $(1.22, 2.20) \times 10^{-38}$ cm$^2$ at a median neutrino energy of 630 MeV, compared with the theoretical prediction of $2.01 \times 10^{-38}$ cm$^2$., Comment: 10 pages, 6 figures
- Published
- 2014
- Full Text
- View/download PDF
5. Precise measurement of the neutrino mixing parameter θ23 from muon neutrino disappearance in an off-axis beam
- Author
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K. Mavrokoridis, F. d. M. Blaszczyk, Y. Kanazawa, S. Berkman, Robert Wilson, Viktor Matveev, L. Southwell, J. D. Perkin, T. J. Irvine, Henry W. Sobel, C. W. Walter, C. Yanagisawa, K. Nishikawa, S. Murphy, J. Myslik, T. Wachala, M. Nirkko, Oleg Mineev, T. Hara, T. Golan, Y. Yamada, Y. Fukuda, D. Autiero, Jan T. Sobczyk, J. L. Palomino, S. W. K. Emery, Gareth J. Barker, M. Hierholzer, M. Ziembicki, P. de Perio, K. Laihem, J. Zalipska, J. Insler, E. Radicioni, A. Murakami, A. Kilinski, A. Himmel, F. Retiere, Y. Totsuka, R. G. Calland, D. Gudin, Yusuke Koshio, S. L. Cartwright, S. M. Oser, A. Konaka, M. Lazos, M. A.M. Rayner, J. P. Coleman, Hiroyuki Sekiya, D. L. Wark, A. K. Ichikawa, S. Bordoni, T. Okusawa, Jungsang Kim, T. Nakai, S. Y. Suzuki, E. Rondio, M. Mezzetto, N. McCauley, S. Roth, E. S. Pinzon Guerra, Th. A. Mueller, Matthew T. Reeves, H. Kakuno, L. Ludovici, T. Wongjirad, S. Manly, K. Connolly, T. Szeglowski, Kendall Mahn, M. Ikeda, A. C. Kaboth, T. Kikawa, Masashi Tanaka, Y. Seiya, J. Schwehr, A. Robert, A. Izmaylov, A. P. Furmanski, Ken Sakashita, H. M. O'Keeffe, Takahiro Hiraki, A. Longhin, J. Marteau, A. Cervera, K. Suzuki, V. Paolone, K. Huang, J. Kameda, P. Przewlocki, Antonin Vacheret, W. R. Kropp, A. Jacob, A. D. Marino, Y. Takeuchi, K. Ieki, D. Karlen, S. R. Dennis, A. Bravar, R. J. Wilkes, D. Terhorst, J. Dumarchez, M. D. Haigh, A. Minamino, I. Lamont, P. Kitching, M. O. Wascko, V. Palladino, J. F. Martin, M. Tzanov, K. Ueno, Yusuke Suda, K. E. Duffy, Iain Alexander Bertram, E. Kearns, M. Kabirnezhad, C. J. Metelko, J. Imber, S. Moriyama, A. Suzuki, Masashi Yokoyama, D. Naples, Z. Williamson, S. Tobayama, E. Poplawska, P. Rojas, S. J. Coleman, Frédéric Dufour, Lester D.R. Thompson, K. Iyogi, R. J. Smith, D. Goeldi, A. Kolaceke, C. Touramanis, J. Adam, S. Di Luise, L. Cremonesi, D. Brailsford, P. Stamoulis, M. Murdoch, R. Poutissou, E. D. Zimmerman, S. Yen, M. Lawe, C. Wilkinson, M. B. Smy, M. Zito, M. Tada, D. Cherdack, P. Jonsson, M. Vagins, M. Malek, R. Ohta, D. R. Hadley, M. Bass, D. Ruterbories, F. Sato, R. Castillo, Yuichi Oyama, D. Sgalaberna, R. P. Litchfield, Antonio Ereditato, N. Yershov, J. Zmuda, K. Abe, R. Sacco, I. Kreslo, A. Redij, A. Zalewska, J. Holeczek, C. McGrew, L. Koch, S. Assylbekov, L. Floetotto, Scott Davis, D. Hansen, Y. Nishimura, S. J. Ives, P. Sinclair, C. A. Miller, Kevin Scott McFarland, G. De Rosa, C. Andreopoulos, M. Sorel, Takashi Kobayashi, B. Quilain, R. A. Owen, W. Toki, S. Nakayama, Hiroaki Aihara, Tsuyoshi Nakaya, R. A. Wendell, M. Ravonel, A. Blondel, S. Horikawa, Akitaka Ariga, M. Posiadala, M. G. Catanesi, C. Hearty, Marco Laveder, Vincenzo Berardi, P. N. Ratoff, Tomoko Ariga, Shigeki Aoki, T. Kutter, M. Macaire, G. Christodoulou, T. Tomura, K. Zaremba, A. V. Waldron, T. Nagasaki, T. Maruyama, S. Short, S. Dytman, Yoshinari Hayato, P. A. Rodrigues, L. Pickard, S. Giffin, G. Vasseur, N. C. Hastings, P. Plonski, T. Yuan, Masato Shiozawa, Atsushi Takeda, T. Duboyski, H. Kubo, T. Tsukamoto, E. L. Mathie, M. Friend, N. J. Buchanan, Joshua Hignight, Masayuki Nakahata, B. Still, Yoshihiro Suzuki, T. Nakadaira, Y. Uchida, J. Caravaca Rodríguez, J. H. Jo, J. R. Wilson, C. Nielsen, A. Haesler, H.A. Tanaka, M. J. Wilking, B. A. Popov, Seiko Hirota, G.D. Barr, S. Bhadra, M. Gonin, Stefan Schoppmann, S. B. Boyd, L. Escudero, M. Miura, M. Yu, C. Lister, J. M. Poutissou, C. Bronner, W. Oryszczak, K. P. Lee, Y. Petrov, J. Steinmann, P. Mijakowski, Kate Scholberg, C. K. Jung, D. Kielczewska, M. Batkiewicz, I. Karpikov, A. Dabrowska, M. Hartz, T. Lindner, C. Densham, T. Akiri, A. C. Weber, T. Hasegawa, S. Mine, N. Grant, G. Collazuol, Mark Scott, J. Marzec, R. Terri, K. Nakayoshi, R. L. Helmer, S. Kumaratunga, A. Thorley, A. Korzenev, Rhiju Das, B. Jamieson, T. Ishii, M. M. Khabibullin, O. Drapier, M. McCarthy, T. Ishida, Koji Nakamura, A. N. Khotjantsev, Y. Fujii, Kimihiro Okumura, M. Barbi, F. Bay, V. Galymov, Michal Dziewiecki, Kazuhiro Yamamoto, E. Mazzucato, L. L. Kormos, T. Sekiguchi, Takaaki Kajita, Y. Shustrov, A. Hillairet, Federico Sanchez, J. Kisiel, D. Payne, K. Gilje, Alexander Finch, André Rubbia, S. Takahashi, T. Dealtry, A. Missert, A. Clifton, R. A. Johnson, B. E. Berger, J. Lagoda, F. Di Lodovico, C. Bojechko, L. Zambelli, K. Koseki, M. Ieva, Yu. G. Kudenko, R. Tacik, O. Perevozchikov, Hajime Tanaka, L. Monfregola, P. Hamilton, L. Magaletti, C. Giganti, E. Iwai, C. Pistillo, B. Smith, E. Reinherz-Aronis, E. Scantamburlo, R.P. Kurjata, S. W. Bentham, I. Z. Danko, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, T2K, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), K., Abe, J., Adam, H. a., Aihara, T., Akiri, C., Andreopoulo, S., Aoki, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, S., Bentham, V., Berardi, B., Berger, S., Berkman, I., Bertram, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Bordoni, S., Boyd, D., Brailsford, A., Bravar, C., Bronner, N., Buchanan, R., Calland, J. C., Rodr??????guez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, L., Cremonesi, A., Dabrowska, I., Danko, R., Da, S., Davi, P. D., Perio, DE ROSA, Gianfranca, T. a., Dealtry, S. b., Denni, C., Densham, F. D., Lodovico, S. D., Luise, O., Drapier, T., Duboyski, K., Duffy, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, S., Emery, A., Ereditato, L., Escudero, A., Finch, L., Floetotto, M., Friend, Y., Fujii, Y., Fukuda, A., Furmanski, V., Galymov, S., Giffin, C., Giganti, K., Gilje, D., Goeldi, T., Golan, M., Gonin, N., Grant, D., Gudin, D., Hadley, A., Haesler, M., Haigh, P., Hamilton, D., Hansen, T., Hara, M. a., Hartz, T., Hasegawa, N., Hasting, Y., Hayato, C., Hearty, R., Helmer, M., Hierholzer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, S., Hirota, J., Holeczek, S., Horikawa, K., Huang, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Irvine, T., Ishida, T., Ishii, S., Ive, E., Iwai, K., Iyogi, A. v., Izmaylov, A., Jacob, B., Jamieson, R., Johnson, J., Jo, P., Jonsson, C., Jung, M., Kabirnezhad, A., Kaboth, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D. a., Karlen, I., Karpikov, E. w., Kearn, M., Khabibullin, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, J., Kisiel, P., Kitching, T., Kobayashi, L., Koch, A., Kolaceke, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, S., Kumaratunga, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, I., Lamont, M., Laveder, M., Lawe, M., Lazo, K., Lee, T., Lindner, C., Lister, R., Litchfield, A., Longhin, L., Ludovici, M., Macaire, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marino, J., Marteau, J., Martin, T., Maruyama, J., Marzec, E., Mathie, V., Matveev, K., Mavrokoridi, E., Mazzucato, M., Mccarthy, N., Mccauley, K., Mcfarland, C., Mcgrew, C., Metelko, M., Mezzetto, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, M., Miura, L., Monfregola, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nagasaki, T., Nakadaira, M. a., Nakahata, T., Nakai, K. w., Nakamura, S., Nakayama, T. y., Nakaya, K., Nakayoshi, D., Naple, C., Nielsen, M., Nirkko, K., Nishikawa, Y., Nishimura, H., O'Keeffe, R., Ohta, K. a., Okumura, T., Okusawa, W., Oryszczak, S., Oser, R., Owen, Y., Oyama, Palladino, Vittorio, J., Palomino, V., Paolone, D., Payne, O., Perevozchikov, J., Perkin, Y., Petrov, L., Pickard, E. P., Guerra, C., Pistillo, P., Plonski, E., Poplawska, B., Popov, M., Posiadala, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, A., Redij, M., Reeve, E., Reinherz Aroni, F., Retiere, A., Robert, P., Rodrigue, P., Roja, E., Rondio, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., S??????nchez, F., Sato, E., Scantamburlo, K., Scholberg, S., Schoppmann, J., Schwehr, M., Scott, Y., Seiya, T., Sekiguchi, H., Sekiya, D., Sgalaberna, M. a., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, R., Smith, M., Smy, J., Sobczyk, H. w., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, Y., Suda, A., Suzuki, K., Suzuki, S., Suzuki, Y. a., Suzuki, T., Szeglowski, R. a., Tacik, M., Tada, S., Takahashi, A., Takeda, Y. x., Takeuchi, H., Tanaka, M., Tanaka, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M. w., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, D. a., Wark, M., Wascko, A. a., Weber, R., Wendell, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, M., Yu, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, J., Zmuda, and Science and Technology Facilities Council (STFC)
- Subjects
Particle physics ,General Physics ,Physics, Multidisciplinary ,MODELS ,General Physics and Astronomy ,FOS: Physical sciences ,MASS ,01 natural sciences ,09 Engineering ,High Energy Physics - Experiment ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Physics and Astronomy (all) ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,SCATTERING ,Muon neutrino ,010306 general physics ,Neutrino oscillation ,DETECTOR ,Mixing (physics) ,01 Mathematical Sciences ,Physics ,Neutrons ,Science & Technology ,02 Physical Sciences ,010308 nuclear & particles physics ,Scattering ,Oscillation ,hep-ex ,Física ,T2K Collaboration ,Physical Sciences ,SYMMETRIES ,High Energy Physics::Experiment ,Neutrino ,High energy physics, Mixing, Parameter estimation, Parameter extraction ,Confidence limit, Energy dependent, Neutrino oscillations, Off-axis neutrino beam, Oscillation parameters, Oscillation probabilities, Precise measurements, Statistical uncertainty ,Beam (structure) ,Energy (signal processing) - Abstract
New data from the T2K neutrino oscillation experiment produce the most precise measurement of the neutrino mixing parameter theta_{23}. Using an off-axis neutrino beam with a peak energy of 0.6 GeV and a data set corresponding to 6.57 x 10^{20} protons on target, T2K has fit the energy-dependent nu_mu oscillation probability to determine oscillation parameters. Marginalizing over the values of other oscillation parameters yields sin^2 (theta_{23}) = 0.514 +0.055/-0.056 (0.511 +- 0.055), assuming normal (inverted) mass hierarchy. The best-fit mass-squared splitting for normal hierarchy is Delta m^2_{32} = (2.51 +- 0.10) x 10^{-3} eV^2/c^4 (inverted hierarchy: Delta m^2_{13} = (2.48 +- 0.10) x 10^{-3} eV^2/c^4). Adding a model of multinucleon interactions that affect neutrino energy reconstruction is found to produce only small biases in neutrino oscillation parameter extraction at current levels of statistical uncertainty., Comment: 8 pages, 4 figures. Final version as published in PRL, with very minor changes from initial version in response to referee comments
- Published
- 2014
6. T2K neutrino flux prediction
- Author
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Y. Fukuda, D. Autiero, R. Ohta, A. Suzuki, S. Tobayama, T. Ishii, M. M. Khabibullin, Masashi Yokoyama, E. Poplawska, S. Dytman, P. Stamoulis, A. Gaudin, A. Laing, D. R. Hadley, V. Galymov, L. Ludovici, W. Toki, J. D. Perkin, S. Nakayama, S. W. K. Emery, Luigi Salvatore Esposito, M. D. Haigh, H. Kubo, C. W. Walter, M. Gonin, L. Escudero, W. Oryszczak, T. Akiri, T. Hasegawa, S. Mine, M. Messina, S. M. Oser, S. Horikawa, Scott Davis, D. Hansen, A. Zalewska, Tsuyoshi Nakaya, G. Kogan, E. Radicioni, S. Short, J. P. A. M. de André, N. C. Hastings, P. Plonski, J. Lagoda, E. Mazzucato, T. Ishida, G. F. Pearce, M. Bass, M. Lawe, Y. Seiya, J. Schwehr, G. De Rosa, Ken Sakashita, R. A. Owen, S. J. Ives, Kimihiro Okumura, D. G. Brook-Roberge, A. V. Waldron, T. Nagasaki, P. A. Rodrigues, C. A. Miller, D. L. Wark, R. Castillo, M. Macaire, Masato Shiozawa, M. Y. Pac, Yuichi Oyama, J. Dobson, Joshua Hignight, Yoshihiro Suzuki, J. Marzec, C. Licciardi, S. Murphy, C. Bojechko, R. P. Litchfield, Antonin Vacheret, W. R. Kropp, Alexander Finch, M. Mezzetto, F. Di Lodovico, T. Yuan, C. K. Jung, A. Haesler, S. Assylbekov, G. Wikström, S. Bhadra, Y. Totsuka, M. A.M. Rayner, M. Day, A. Longhin, J. Marteau, Z. Williamson, C. Hearty, Hiroyuki Sekiya, D. Cherdack, K. Abe, R. Sacco, C. McGrew, C. Andreopoulos, T. Szeglowski, M. Murdoch, D. Kielczewska, M. Batkiewicz, I. Taylor, A. Dabrowska, T. Tomura, Akitaka Ariga, E. L. Mathie, Yu. G. Kudenko, J. F. Martin, G. Jover-Manas, M. Tzanov, J. Caravaca Rodríguez, T. Dealtry, H.A. Tanaka, Iain Alexander Bertram, S. Yen, J. Imber, S. Moriyama, T. Yano, T. Wongjirad, A. Murakami, H. Kaji, A. D. Marino, S. J. Coleman, B. Quilain, F. Retiere, L. Monfregola, Takahiro Hiraki, A. Marchionni, A. Missert, P. Guzowski, P. Mijakowski, K. Koseki, C. J. Metelko, E. Frank, A. Bravar, K. Zaremba, Kendall Mahn, M. Sorel, Marco Laveder, C. Touramanis, M. B. Smy, S. B. Boyd, Antonio Ereditato, N. Yershov, Shigeki Aoki, T. Lindner, A. Himmel, K. Huang, Atsushi Takeda, P. de Perio, M. Ieva, L. Magaletti, C. Giganti, R. Poutissou, T. Nakai, M. Shibata, P. Masliah, Jing Wang, L. L. Kormos, E. Rondio, N. McCauley, J. M. Poutissou, C. Bronner, Kevin Scott McFarland, R. A. Wendell, Takashi Kobayashi, S. Giffin, Vincenzo Berardi, R. G. Calland, D. Gudin, B. Rossi, S. Di Luise, D. Naples, K. Nakajima, M. Tada, Yukika Nishimura, A. Hyndman, T. Maruyama, Y. Obayashi, C. Densham, T. Nakadaira, P. Jonsson, K. Suzuki, A. C. Weber, Y. Takeuchi, R. Tacik, O. Perevozchikov, M. Ravonel, J. Kisiel, A. K. Ichikawa, A. Curioni, J. Kameda, J. H. Jo, K. Kowalik, M. Szeptycka, Tomoko Ariga, A. Izmaylov, F. Khanam, G.D. Barr, M. J. Wilking, S. Roth, V. Paolone, S. Berkman, L. Southwell, M. Miura, J. J. Gomez-Cadenas, T. Nicholls, P. Przewlocki, P. Sinclair, J. Myslik, K. Gilje, A. Cervera, S. Manly, E. S. Pinzon Guerra, T. Sekiguchi, A. Hillairet, Kodai Matsuoka, G. Christodoulou, R. Terri, G. Vasseur, Th. A. Mueller, Matthew T. Reeves, S. B. Kim, Lester D.R. Thompson, Viktor Matveev, V. Palladino, T. McLachlan, J. Y. Kim, A. Blondel, M. M. Tanaka, K. P. Lee, Koji Nakamura, A. N. Khotjantsev, Y. Fujii, T. Golan, Minoru Otani, D. Ruterbories, R. J. Smith, M. Vagins, R. Sulej, H. Kakuno, Y. Yamada, J. Steinmann, A. Minamino, H. M. O'Keeffe, I. Karpikov, André Rubbia, A. Kilinski, Yoshinari Hayato, J. Holeczek, S. L. Cartwright, K. Connolly, A. Thorley, A. Korzenev, J. R. Wilson, C. Nielsen, M. Dziomba, P. Kitching, B. Smith, E. Reinherz-Aronis, S. Takahashi, T. Kikawa, M. O. Wascko, K. K. Joo, T. Wachala, E. Kearns, Hiroaki Aihara, P. N. Ratoff, N. J. Buchanan, Rhiju Das, M. Posiadala, M. G. Catanesi, E. Scantamburlo, J. Dumarchez, M. Malek, R.P. Kurjata, A. Clifton, S. W. Bentham, D. Terhorst, T. Duboyski, Jungsang Kim, S. Y. Suzuki, B. Jamieson, K. Nakayoshi, Masayuki Nakahata, Justin Albert, N. Abgrall, C. Lister, Y. Uchida, I. Z. Danko, Yusuke Koshio, M. Ikeda, B. Still, Henry W. Sobel, R. L. Helmer, S. Kumaratunga, T. Kutter, Masashi Tanaka, M. Friend, R. A. Johnson, K. Nishikawa, D. I. Scully, K. Iyogi, N. Grant, Jan T. Sobczyk, E. D. Zimmerman, K. Mavrokoridis, K. Ieki, K. Laihem, D. Karlen, R. J. Wilkes, F. d. M. Blaszczyk, C. Wilkinson, G. Collazuol, Mark Scott, C. Yanagisawa, Gareth J. Barker, Dmitriy Beznosko, J. P. Coleman, Y. Kanazawa, K. Ueno, M. Zito, B. Kirby, I. Kreslo, T. Tsukamoto, Oleg Mineev, B. A. Popov, Takaaki Kajita, G. D. Lopez, Y. Shustrov, Kate Scholberg, Federico Sanchez, M. Ziembicki, C. Matsumura, D. Payne, M. Barbi, M. Hartz, J. Insler, F. Bay, Michal Dziewiecki, Kazuhiro Yamamoto, Frédéric Dufour, I. T. Lim, Robert Wilson, T. Hara, A. Konaka, J. Åmuda, B. E. Berger, L. Zambelli, Ministry of Education and Science of the Russian Federation, Ministry of Education, Culture, Sports, Science and Technology (Japan), Natural Sciences and Engineering Research Council of Canada, Centro Nacional de Física de Partículas, Astropartículas y Nuclear (España), Russian Foundation for Basic Research, Abgrall, Nicolas, Blondel, Alain, Bravar, Alessandro, Dufour, Fanny, Haesler, Alexis, Korzenev, Alexander, Murphy, Sébastien, Ravonel Salzgeber, Melody, Rayner, Mark, Scantamburlo, Enrico, Wikstrom, Gustav, K., Abe, N., Abgrall, H., Aihara, T., Akiri, J., Albert, C., Andreopoulo, S., Aoki, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, S., Bentham, V., Berardi, B., Berger, S., Berkman, I., Bertram, D., Beznosko, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Boyd, A., Bravar, C., Bronner, D., Brook Roberge, N., Buchanan, R., Calland, J. C., Rodríguez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, A., Curioni, A., Dabrowska, I., Danko, R., Da, S., Davi, M., Day, J. D., André, P. D., Perio, DE ROSA, Gianfranca, T., Dealtry, C., Densham, F. D., Lodovico, S. D., Luise, J., Dobson, T., Duboyski, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, M., Dziomba, S., Emery, A., Ereditato, L., Escudero, L., Esposito, A., Finch, E., Frank, M., Friend, Y., Fujii, Y., Fukuda, V., Galymov, A., Gaudin, S., Giffin, C., Giganti, K., Gilje, T., Golan, J., Gomez Cadena, M., Gonin, N., Grant, D., Gudin, P., Guzowski, D., Hadley, A., Haesler, M., Haigh, D., Hansen, T., Hara, M., Hartz, T., Hasegawa, N., Hasting, Y., Hayato, C., Hearty, R., Helmer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, J., Holeczek, S., Horikawa, K., Huang, A., Hyndman, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Ishida, T., Ishii, S., Ive, K., Iyogi, A., Izmaylov, B., Jamieson, R., Johnson, J., Jo, P., Jonsson, K., Joo, G., Jover Mana, C., Jung, H., Kaji, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D., Karlen, I., Karpikov, E., Kearn, M., Khabibullin, F., Khanam, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, S., Kim, B., Kirby, J., Kisiel, P., Kitching, T., Kobayashi, G., Kogan, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, K., Kowalik, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, S., Kumaratunga, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, A., Laing, M., Laveder, M., Lawe, K., Lee, C., Licciardi, I., Lim, T., Lindner, C., Lister, R., Litchfield, A., Longhin, G., Lopez, L., Ludovici, M., Macaire, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marchionni, A., Marino, J., Marteau, J., Martin, T., Maruyama, J., Marzec, P., Masliah, E., Mathie, C., Matsumura, K., Matsuoka, V., Matveev, K., Mavrokoridi, E., Mazzucato, N., Mccauley, K., Mcfarland, C., Mcgrew, T., Mclachlan, M., Messina, C., Metelko, M., Mezzetto, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, M., Miura, L., Monfregola, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nagasaki, T., Nakadaira, M., Nakahata, T., Nakai, K., Nakajima, K., Nakamura, S., Nakayama, T., Nakaya, K., Nakayoshi, D., Naple, T., Nicholl, C., Nielsen, K., Nishikawa, Y., Nishimura, H., O'Keeffe, Y., Obayashi, R., Ohta, K., Okumura, W., Oryszczak, S., Oser, M., Otani, R., Owen, Y., Oyama, M., Pac, Palladino, Vittorio, V., Paolone, D., Payne, G., Pearce, O., Perevozchikov, J., Perkin, E. P., Guerra, P., Plonski, E., Poplawska, B., Popov, M., Posiadala, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, M., Reeve, E., Reinherz Aroni, F., Retiere, P., Rodrigue, E., Rondio, B., Rossi, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., Sánchez, E., Scantamburlo, K., Scholberg, J., Schwehr, M., Scott, D., Scully, Y., Seiya, T., Sekiguchi, H., Sekiya, M., Shibata, M., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, R., Smith, M., Smy, J., Sobczyk, H., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, R., Sulej, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, M., Szeptycka, R., Tacik, M., Tada, S., Takahashi, A., Takeda, Y., Takeuchi, H., Tanaka, M., Tanaka, I., Taylor, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, J., Wang, D., Wark, M., Wascko, A., Weber, R., Wendell, G., Wikström, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, T., Yano, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, A., Zalewska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, and J., Åmuda
- Subjects
Nuclear and High Energy Physics ,Particle physics ,Physics::Instrumentation and Detectors ,Solar neutrino ,Astrophysics::High Energy Astrophysical Phenomena ,ddc:500.2 ,Antiprotons ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,Nuclear physics ,Pions ,0103 physical sciences ,Momentum range ,Muon neutrino ,010306 general physics ,Neutrino oscillation ,Nuclear Experiment ,QC ,Physics ,Gev-c ,010308 nuclear & particles physics ,Particle-production ,High Energy Physics::Phenomenology ,T2K experiment ,Física ,Detector ,Monitor ,Solar neutrino problem ,Nuclei ,Neutrino detector ,13. Climate action ,Measurements of neutrino speed ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,Neutrino ,Protons ,Absorption cross-sections ,Particle Physics - Experiment - Abstract
The Tokai-to-Kamioka (T2K) experiment studies neutrino oscillations using an off-axismuon neutrino beam with a peak energy of about 0.6 GeV that originates at the Japan Proton Accelerator Research Complex accelerator facility. Interactions of the neutrinos are observed at near detectors placed at 280 m from the production target and at the far detector-Super-Kamiokande-located 295 km away. The flux prediction is an essential part of the successful prediction of neutrino interaction rates at the T2K detectors and is an important input to T2K neutrino oscillation and cross section measurements. A FLUKA and GEANT3-based simulation models the physical processes involved in the neutrino production, from the interaction of primary beam protons in the T2K target, to the decay of hadrons and muons that produce neutrinos. The simulation uses proton beam monitor measurements as inputs. The modeling of hadronic interactions is reweighted using thin target hadron production data, including recent charged pion and kaon measurements from the NA61/SHINE experiment. For the first T2K analyses the uncertainties on the flux prediction are evaluated to be below 15% near the flux peak. The uncertainty on the ratio of the flux predictions at the far and near detectors is less than 2% near the flux peak., We thank the J-PARC accelerator team for the superb accelerator performance and the J-PARC center for the continuous support of the T2K experiment. We are grateful to the NA61/SHINE collaboration and FLUKA team for their assistance to make our data-driven flux prediction. We acknowledge the support of MEXT, Japan; NSERC, NRC and CFI, Canada; CEA and CNRS/IN2P3, France; DFG, Germany; INFN, Italy; National Science Centre, Poland; RAS, RFBR and the Ministry of Education and Science of the Russian Federation; MEST and NRF, South Korea; MICINN and CPAN, Spain; SNSF and SER, Switzerland; STFC, U.K.; NSF and DOE, U.S.. We also thank CERN for their donation of the UA1/NOMAD magnet and DESY for the HERA-B magnet mover system. In addition, participation of individual researchers and institutions in T2K has been further supported by funds from: ERC (FP7), E.U.; JSPS, Japan; Royal Society, U.K.; DOE Early Career program; and the A.P. Sloan Foundation, U.S.
- Published
- 2013
7. Recent Results from the T2K Experiment
- Author
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Yuichi Oyama, R. P. Litchfield, S. Assylbekov, Koji Yamamoto, K. Abe, A. Cervera, V. Palladino, C. Yanagisawa, A. Blondel, V. Galymov, T. Tomura, E. Mazzucato, G. F. Pearce, M. Ziembicki, R. Ohta, W. R. Kropp, Y. Totsuka, J. Zalipska, J. Insler, E. L. Mathie, M. Ravonel, Susumu Takahashi, S. Tobayama, M. Lawe, S. J. Coleman, J. Lagoda, A. Himmel, R. G. Calland, Y. Takeuchi, Gareth J. Barker, D. Gudin, T. Wongjirad, K. Sakashita, J. Caravaca Rodríguez, H.A. Tanaka, A. Thorley, A. Korzenev, K. Nishikawa, G. D. Lopez, M. Lazos, T. Kajita, Minoru Otani, S. M. Oser, S. B. Boyd, Y. Shustrov, Robert Wilson, Antonin Vacheret, M. Tzanov, M. Hierholzer, D. Ruterbories, C. Touramanis, Antonio Ereditato, N. Yershov, C. J. Metelko, Rhiju Das, H. W. Sobel, C. Licciardi, J. P. Coleman, C. Bojechko, Kevin Scott McFarland, I. Taylor, S. Horikawa, Y. Seiya, B. Jamieson, A. Zalewska, Federico Sanchez, C. J. Densham, Jan T. Sobczyk, S. Short, N. C. Hastings, P. Plonski, M. Zito, Hidekazu Kakuno, Hiroaki Aihara, T. Maruyama, S. Mine, P. N. Ratoff, T. Ishii, G. Christodoulou, J. Holeczek, T. Kutter, K. Nakayoshi, K. Laihem, B. Quilain, S. Murphy, Mauricio Barbi, R. L. Helmer, I. Kreslo, S. Kumaratunga, E. Frank, Marco Laveder, J. M. Poutissou, C. Bronner, M. Ieva, E. Kearns, Masashi Yokoyama, N. J. Buchanan, J. H. Jo, G.D. Barr, K. K. Joo, T. Wachala, M. Friend, L. Southwell, T. Dealtry, J. Myslik, C. W. Walter, E. Poplawska, R. Tacik, A. Missert, J. Zmuda, O. Perevozchikov, S. R. Dennis, A. Bravar, F. Retiere, T. Golan, S. Moriyama, P. Stamoulis, K. Ieki, K. Koseki, Y. Nishimura, T. J. Irvine, Yusuke Koshio, Takahiro Hiraki, D. Karlen, D. Brailsford, I. Karpikov, K. Zaremba, Yuki Fujii, R. Poutissou, O. V. Mineev, A. Gaudin, Masayuki Nakahata, A. Konaka, L. L. Kormos, André Rubbia, Tsuyoshi Nakaya, P. Masliah, C. K. Jung, Hidetoshi Kubo, Atsushi Takeda, R. J. Wilkes, D. Kielczewska, M. Batkiewicz, Y. Uchida, K. P. Lee, W. H. Toki, A. V. Waldron, T. Nagasaki, T. Akiri, M. Ikeda, P. Jonsson, Rosario Castillo, A. Dabrowska, A. Longhin, B. A. Popov, P. A. Rodrigues, J. Dumarchez, G. Kogan, J. Marteau, J. Schwehr, F. Bay, Hiroyuki Sekiya, T. Szeglowski, T. Hasegawa, T. Tsukamoto, A. Robert, Masato Shiozawa, L. Ludovici, C. Wilkinson, Janusz Marzec, F. Dufour, G. De Rosa, Z. Williamson, Akitaka Ariga, Ko Okumura, Y. Fukuda, A. Izmaylov, K. Mavrokoridis, F. d. M. Blaszczyk, R. A. Owen, A. Haesler, A. Clifton, D. Sgalaberna, Y. Kanazawa, Joshua Hignight, Kendall Mahn, Yoshihiro Suzuki, A. Redij, S. B. Kim, B. E. Berger, S. Bhadra, S. Emery, P. Sinclair, Scott Davis, D. Hansen, J. D. Perkin, A. J. Finch, R. A. Johnson, T. Lindner, M. A. M. Rayner, S. J. Ives, Shigeki Aoki, David Hadley, J.J. Gómez-Cadenas, K. Gilje, M. Macaire, T. Ishida, M. Miura, Michal Dziewiecki, S. Giffin, A. N. Khotjantsev, A. Kolaceke, E. Radicioni, S. Manly, M. J. Wilking, T. Yuan, V. Matveev, D. L. Wark, T. Duboyski, L. Zambelli, J. Steinmann, S. L. Cartwright, C. A. Miller, A. Minamino, Kate Scholberg, K. Connolly, T. Hara, A. D. Marino, Yusuke Suda, M. Malek, D. Terhorst, M. Hartz, Masashi Tanaka, Iain Alexander Bertram, A. P. Furmanski, J. Imber, V. Paolone, A. Jacob, K. Iyogi, E. D. Zimmerman, R. A. Wendell, A. C. Weber, A. Kilinski, J. R. Wilson, C. Nielsen, T. Okusawa, Jungsang Kim, S. Y. Suzuki, M. Bass, A. C. Kaboth, S. Berkman, N. Abgrall, C. Lister, Vincenzo Berardi, Tomoko Ariga, G. Vasseur, N. Grant, G. Collazuol, Mark Scott, M. Posiadala, M. G. Catanesi, T. Nakai, E. Rondio, N. McCauley, R. Terri, K. Huang, P. Przewlocki, Lester D.R. Thompson, M. R. Vagins, A. Murakami, I. T. Lim, C. Hearty, B. Still, Richard J.H. Smith, Jan Kisiel, T. Kobayashi, S. Di Luise, L. Cremonesi, A. Curioni, A. T. Suzuki, J. F. Martin, D. Autiero, T. Nakadaira, M. Nirkko, C. Pistillo, B. Smith, E. Reinherz-Aronis, Y. Petrov, E. Scantamburlo, R.P. Kurjata, S. W. Bentham, D. Cherdack, I. Z. Danko, M. B. Smy, S. A. Dytman, Koh Ueno, R. Sacco, F. Di Lodovico, M. Tada, D. J. Payne, C. McGrew, Yu. G. Kudenko, L. Monfregola, P. Hamilton, M. Murdoch, Y. Hayato, C. Andreopoulos, S. Nakayama, S. Yen, M. M. Khabibullin, L. Magaletti, C. Giganti, M. Y. Pac, O. Drapier, Seiko Hirota, A. K. Ichikawa, A. Hillairet, S. Roth, J. Kameda, T. Kikawa, E. S. Pinzon Guerra, M. Gonin, Th. A. Mueller, Matthew T. Reeves, P. Mijakowski, L. Escudero, W. Oryszczak, H. M. O'Keeffe, Kazuhiro Suzuki, P. Kitching, M. O. Wascko, T. Sekiguchi, M. Sorel, M. D. Haigh, Koji Nakamura, P. de Perio, Yoshikazu Yamada, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), T2K, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), K., Abe, N., Abgrall, H., Aihara, T., Akiri, C., Andreopoulo, S., Aoki, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, M., Barbi, G., Barker, G., Barr, M., Ba, M., Batkiewicz, F., Bay, S., Bentham, V., Berardi, B., Berger, S., Berkman, I., Bertram, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, S., Boyd, D., Brailsford, A., Bravar, C., Bronner, N., Buchanan, R., Calland, J. C., Rodr??????guez, S., Cartwright, R., Castillo, M., Catanesi, A., Cervera, D., Cherdack, G., Christodoulou, A., Clifton, J., Coleman, S., Coleman, G., Collazuol, K., Connolly, L., Cremonesi, A., Curioni, A., Dabrowska, I., Danko, R., Da, S., Davi, P. d., Perio, DE ROSA, Gianfranca, T. a., Dealtry, S. b., Denni, C., Densham, F. D., Lodovico, S. D., Luise, O., Drapier, T., Duboyski, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, S., Emery, A., Ereditato, L., Escudero, A., Finch, E., Frank, M., Friend, Y., Fujii, Y., Fukuda, A., Furmanski, V., Galymov, A., Gaudin, S., Giffin, C., Giganti, K., Gilje, T., Golan, J., Gomez Cadena, M., Gonin, N., Grant, D., Gudin, D., Hadley, A., Haesler, M., Haigh, P., Hamilton, D., Hansen, T., Hara, M. b., Hartz, T., Hasegawa, N., Hasting, Y., Hayato, C., Hearty, R., Helmer, M., Hierholzer, J., Hignight, A., Hillairet, A., Himmel, T., Hiraki, S., Hirota, J., Holeczek, S., Horikawa, K., Huang, A., Ichikawa, K., Ieki, M., Ieva, M., Ikeda, J., Imber, J., Insler, T., Irvine, T., Ishida, T., Ishii, S., Ive, K., Iyogi, A. x., Izmaylov, A., Jacob, B., Jamieson, R., Johnson, J., Jo, P., Jonsson, K., Joo, C. a., Jung, A., Kaboth, T., Kajita, H., Kakuno, J., Kameda, Y., Kanazawa, D. b., Karlen, I., Karpikov, E., Kearn, M., Khabibullin, A., Khotjantsev, D., Kielczewska, T., Kikawa, A., Kilinski, J., Kim, S., Kim, J., Kisiel, P., Kitching, T., Kobayashi, G., Kogan, A., Kolaceke, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, S., Kumaratunga, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, M., Laveder, M., Lawe, M., Lazo, K., Lee, C., Licciardi, I., Lim, T., Lindner, C., Lister, R. b., Litchfield, A., Longhin, G., Lopez, L., Ludovici, M., Macaire, L., Magaletti, K., Mahn, M., Malek, S., Manly, A., Marino, J., Marteau, J., Martin, T., Maruyama, J., Marzec, P., Masliah, E., Mathie, V., Matveev, K., Mavrokoridi, E., Mazzucato, N., Mccauley, K., Mcfarland, C., Mcgrew, C., Metelko, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, M., Miura, L., Monfregola, S., Moriyama, T., Mueller, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nagasaki, T., Nakadaira, M., Nakahata, T., Nakai, K. y., Nakamura, S., Nakayama, T., Nakaya, K., Nakayoshi, C., Nielsen, M., Nirkko, K., Nishikawa, Y., Nishimura, H., O'Keeffe, R., Ohta, K., Okumura, T., Okusawa, W., Oryszczak, S., Oser, M., Otani, R., Owen, Y., Oyama, M., Pac, Palladino, Vittorio, V., Paolone, D., Payne, G., Pearce, O., Perevozchikov, J., Perkin, Y., Petrov, E. P., Guerra, C., Pistillo, P., Plonski, E., Poplawska, B., Popov, M., Posiadala, J., Poutissou, R., Poutissou, P., Przewlocki, B., Quilain, E., Radicioni, P., Ratoff, M., Ravonel, M., Rayner, A., Redij, M., Reeve, E., Reinherz Aroni, F., Retiere, A., Robert, P., Rodrigue, E., Rondio, S., Roth, A., Rubbia, D., Ruterborie, R., Sacco, K., Sakashita, F., S??????nchez, E., Scantamburlo, K., Scholberg, J., Schwehr, M., Scott, Y., Seiya, T., Sekiguchi, H., Sekiya, D., Sgalaberna, M., Shiozawa, S., Short, Y., Shustrov, P., Sinclair, B., Smith, R., Smith, M., Smy, J., Sobczyk, H., Sobel, M., Sorel, L., Southwell, P., Stamouli, J., Steinmann, B., Still, Y., Suda, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, R. b., Tacik, M., Tada, S., Takahashi, A., Takeda, Y., Takeuchi, H., Tanaka, M., Tanaka, I., Taylor, D., Terhorst, R., Terri, L., Thompson, A., Thorley, S., Tobayama, W., Toki, T., Tomura, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M. y., Vagin, G., Vasseur, T., Wachala, A., Waldron, C., Walter, D. a., Wark, M., Wascko, A. a., Weber, R., Wendell, R., Wilke, M., Wilking, C., Wilkinson, Z., Williamson, J., Wilson, R., Wilson, T., Wongjirad, Y., Yamada, K., Yamamoto, C., Yanagisawa, S., Yen, N., Yershov, M., Yokoyama, T., Yuan, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, and J., Zmuda
- Subjects
θ13 ,Nuclear and High Energy Physics ,Particle physics ,Physics::Instrumentation and Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,Solar neutrino ,Neutrino Oscillation ,01 natural sciences ,7. Clean energy ,Nuclear physics ,Long Baseline ,Atomic and Molecular Physics ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,010306 general physics ,Neutrino oscillation ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,ComputingMilieux_MISCELLANEOUS ,T2K ,Physics ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,T2K experiment ,Solar neutrino problem ,Atomic and Molecular Physics, and Optics ,Neutrino detector ,Measurements of neutrino speed ,High Energy Physics::Experiment ,and Optics ,Neutrino ,Neutrino astronomy - Abstract
The Tokai to Kamioka (T2K) experiment studies neutrino oscillations using a beam of muon neutrinos produced by an accelerator. The neutrinos travel from J-PARC on the east coast of Japan and are detected 295 kilometers further away in the Super-Kamiokande detector. A complex of near detectors located 280 meters away from the neutrino production target is used to better characterize the neutrino beam and reduce systematic uncertainties. The experiment aims at measuring electronic neutrino appearance ( ν μ → ν e oscillation) to measure the neutrino mixing angle θ 13 , and muon neutrino disappearance to measure the neutrino mixing angle θ 23 and mass splitting | Δ m 32 2 |. We report here electron neutrino appearance results using three years of data, recorded until the 2012 summer, as well as muon neutrino disappearance results based on the data coming from the first two years of the experiment.
- Published
- 2012
8. Indication of electron neutrino appearance from an accelerator-produced off-axis muon neutrino beam
- Author
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S. Roth, J. Lagoda, M. Iwasaki, Paul Fraser Harrison, T. Okusawa, Jungsang Kim, S. Y. Suzuki, M. Ikeda, M. Bass, F. Pierre, R. A. Wendell, C. Bojechko, C. W. Walter, B. A. Popov, Vincenzo Berardi, P. T. Le, P. Mijakowski, C. Licciardi, Tomoko Ariga, J. Ilic, M. Ravonel, T. Maruyama, E. L. Mathie, V. Galymov, T. Ishii, M. A. George, I. Taylor, G. Vasseur, T. Nakadaira, Kazuhiro Suzuki, M. Ieva, Hirokatsu Ohhata, Y. Fukuda, D. Autiero, P. Paul, Kate Scholberg, M. M. Khabibullin, A. Yamamoto, Toru Ogitsu, F. Khanam, G.D. Barr, T. Maryon, Michel Raymond, P. Kitching, R. Tacik, M. Hartz, G. Christodoulou, S. B. Boyd, J. R. Wilson, K. K. Joo, T. Wachala, E. Frank, M. O. Wascko, C. A. Chavez, Marco Laveder, A. Ferrero, B. Hartfiel, A. C. Weber, E. Kearns, K. P. Lee, Justin Albert, N. Abgrall, M. Szeptycka, M. M. Tanaka, Leigh H. Whitehead, J. P.A.M. De André, E. Mazzucato, Sy Suzuki, Y. Obayashi, K. Mavrokoridis, G. F. Pearce, J. J. Walding, A. Suzuki, J. Myslik, N. Grant, André Rubbia, M. Murdoch, S. W. K. Emery, Masayuki Nakahata, P. de Perio, G. Collazuol, Mark Scott, Yusuke Koshio, Masashi Tanaka, S. Yen, T. Ishida, Yoshikazu Yamada, F. d. M. Blaszczyk, T. Yano, T. Golan, Biagio Rossi, Hiroyuki Sekiya, Y. Uchida, C. Hansen, C. A. Miller, A. Minamino, M. Day, V. Paolone, P. Sutcliffe, Masashi Yokoyama, E. Poplawska, R. Poutissou, Hs Budd, P. Masliah, T. Szeglowski, Soo-Bong Kim, A. Longhin, Michael Litos, J. Marteau, O. Drapier, K. Iyogi, F. Moreau, E. D. Zimmerman, M. Iida, B. Morgan, M. A. Ward, Tomiyoshi Haruyama, J. M. Levy, L. L. Kormos, T. Kikawa, C. Touramanis, Kendall Mahn, Robert Henderson, A. Hatzikoutelis, H. Kaji, R. A. Johnson, Antonio Ereditato, H. Nishino, M. Zito, N. Yershov, A. Cazes, K. Zaremba, B. Kirby, I. Kreslo, J. Dumarchez, Kevin Scott McFarland, A. Cervera, Henry W. Sobel, V. Palladino, Tsuyoshi Nakaya, Takashi Kobayashi, M. Malek, J. Y. Kim, J. Kisiel, T. M. Raufer, T. Hasegawa, S. Mine, Y. Takeuchi, A. Delbart, J. D. Perkin, Scott Davis, D. Hansen, R. Sulej, Atsushi Takeda, Takaaki Kajita, G. D. Lopez, Oleg Mineev, K. Hamano, R. Castillo, Yuichi Oyama, T. Tsukamoto, S. J. Ives, R. P. Litchfield, Takayuki Tomaru, Masato Shiozawa, M. Ziembicki, S. Sabouri, Ken Sakashita, Norio Higashi, J. Zalipska, Minoru Otani, David Calvet, C. Strabel, S. Assylbekov, M. Siyad, V. Pettinacci, K. Gilje, A. Zalewska, Federico Sanchez, M. Fechner, A. Haesler, Fred Gannaway, Alexander Finch, D. Ruterbories, G. Wikström, S. Bhadra, Akitaka Ariga, Antonin Vacheret, W. R. Kropp, K. Kowalik, J. Marzec, C. Matsumura, D. Payne, T. Hara, J. F. Martin, M. Tzanov, C. J. Metelko, Koji Nakamura, M. Barbi, Hiroaki Aihara, G. Jover-Manas, A. Carver, Shigeki Aoki, P. N. Ratoff, T. Kutter, S. Giffin, A. N. Khotjantsev, Y. Fujii, W. Coleman, A. Gendotti, A. Missert, F. Bay, M. Miura, T. Ozaki, A. Muir, Kodai Matsuoka, P. Guzowski, A. Bravar, Frédéric Dufour, C. Yanagisawa, K. Nishikawa, G. P. Ward, I. T. Lim, R. Terri, J. Holeczek, P. Wanderer, J. J. Gomez-Cadenas, Michal Dziewiecki, Kazuhiro Yamamoto, Jan T. Sobczyk, K. Laihem, N. Kimura, H. Kubo, K. Nakajima, M. Tada, P. Gumplinger, R. L. Helmer, Gareth J. Barker, Kimihiro Okumura, K. Koseki, Y. Shimizu, Dmitriy Beznosko, D. G. Brook-Roberge, S. M. Oser, J. P. Coleman, Y. Seiya, J. Schwehr, Yasuo Ajima, T. McLachlan, S. Horikawa, A. Blondel, M. Goldhaber, S. Yamada, K. Ieki, D. Karlen, R. J. Wilkes, D. I. Scully, N. J. Buchanan, P. A. Rodrigues, E. Radicioni, M. L. Navin, H.A. Tanaka, Yoshinari Hayato, C. K. Jung, D. L. Wark, M. Y. Pac, Achim Stahl, J. L. Stone, D. Kielczewska, A. Dabrowska, A. D. Marino, J. M. Poutissou, C. Bronner, N. West, I. Kato, K. Kaneyuki, T. C. Nicholls, Gavin Davies, U. Dore, P. Stamoulis, A. Thorley, A. Korzenev, L. Ludovici, M. Sorel, A. Gaudin, W. Qian, T. Lindner, C. Densham, G. Kogan, G. De Rosa, S. Hastings, R. A. Owen, M. D. Haigh, A. Badertscher, M. Macaire, Y. Takenaga, M. J. Wilking, Rhiju Das, S. Dytman, B. Jamieson, J. L. Raaf, J. Bouchez, Thorsten Lux, O. Araoka, M. Gonin, L. Escudero, Kenichi Tanaka, J. Steinmann, K. Abe, R. Sacco, S. L. Cartwright, A. Terashima, C. McGrew, K. Connolly, C. Andreopoulos, D. Terhorst, T. Nakai, Jing Wang, E. Rondio, P. Dinh Tran, N. McCauley, K. Mizouchi, Viktor Matveev, M. Noy, N. Tanimoto, Iain Alexander Bertram, J. Imber, S. Moriyama, M. B. Smy, M. Shibata, A. Hyndman, J. Kameda, P. Przewlocki, P. F. Loverre, J. M. Roney, Lester D.R. Thompson, Y. Kouzuma, L. R. Sulak, M. Mezzetto, R.P. Kurjata, S. W. Bentham, I. Z. Danko, K. Sasaki, K. Tashiro, Koh Ueno, Katsuyu Kasami, Yasuhiro Makida, N. Kulkarni, C. Hearty, T. Sekiguchi, Tatsushi Nakamoto, Alastair Grant, Richard J.H. Smith, G. Mituka, A. Murakami, Yutaka Yamanoi, Hiroshi Yamaoka, A. Marchionni, S. Di Luise, F. Di Lodovico, A. Curioni, K. Hayashi, Barry L. Nelson, Yu. G. Kudenko, L. Monfregola, S. Koike, S. Manly, M. Vagins, B. Andrieu, C. Giganti, B. Still, J. A. Nowak, C. Ishihara, M. Dziomba, Eiichi Hirose, M. Posiadala, M. G. Catanesi, V. Kravtsov, S. Murphy, F. Retiere, Y. Totsuka, Susumu Takahashi, W. Metcalf, T. Wongjirad, S. Nakayama, A. Sarrat, S. Short, N. C. Hastings, D. Naples, A. Robert, A. Izmaylov, Steve K. Choi, J. Zmuda, M. Messina, A. V. Waldron, M. Besnier, J. Dobson, Joshua Hignight, Yoshihiro Suzuki, Robert Wilson, Takahiro Okamura, J. Argyriades, J. Beucher, A. Konaka, W. H. Toki, B. E. Berger, H. Kakuno, L. Zambelli, A. K. Ichikawa, Luigi Salvatore Esposito, Escudero Sanchez, Lorena [0000-0003-3464-9206], Whitehead, Leigh [0000-0002-3327-2534], Apollo - University of Cambridge Repository, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Département d'Electronique, des Détecteurs et d'Informatique (ex SEDI) (DEDI), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, T2K, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Département d'Electronique, des Détecteurs et d'Informatique pour la Physique (ex SEDI) (DEDIP), Abgrall, Nicolas, Argyriades, Jeremy, Blondel, Alain, Bravar, Alessandro, Dufour, Fanny, Ferrero, Andréa, Haesler, Alexis, Korzenev, Alexander, Murphy, Sébastien, Ravonel Salzgeber, Melody, Wikstrom, Gustav, K., Abe, N., Abgrall, Y., Ajima, H., Aihara, J., Albert, C., Andreopoulo, B., Andrieu, S., Aoki, O., Araoka, J., Argyriade, A., Ariga, T., Ariga, S., Assylbekov, D., Autiero, A., Badertscher, M., Barbi, G., Barker, G., Barr, M., Ba, F., Bay, S., Bentham, V., Berardi, B., Berger, I., Bertram, M., Besnier, J., Beucher, D., Beznosko, S., Bhadra, F., Blaszczyk, A., Blondel, C., Bojechko, J., Bouchez, S., Boyd, A., Bravar, C., Bronner, D., Brook Roberge, N., Buchanan, H., Budd, D., Calvet, S., Cartwright, A., Carver, R., Castillo, M., Catanesi, A., Caze, A., Cervera, C., Chavez, S., Choi, G., Christodoulou, J., Coleman, W., Coleman, G., Collazuol, K., Connolly, A., Curioni, A., Dabrowska, I., Danko, R., Da, G., Davie, S., Davi, M., Day, DE ROSA, Gianfranca, J., de André, P., de Perio, A., Delbart, C., Densham, F., Di Lodovico, S., Di Luise, P., Dinh Tran, J., Dobson, U., Dore, O., Drapier, F., Dufour, J., Dumarchez, S., Dytman, M., Dziewiecki, M., Dziomba, S., Emery, A., Ereditato, L., Escudero, L., Esposito, M., Fechner, A., Ferrero, A., Finch, E., Frank, Y., Fujii, Y., Fukuda, V., Galymov, F., Gannaway, A., Gaudin, A., Gendotti, M., George, S., Giffin, C., Giganti, K., Gilje, T., Golan, M., Goldhaber, J., Gomez Cadena, M., Gonin, N., Grant, A., Grant, P., Gumplinger, P., Guzowski, A., Haesler, M., Haigh, K., Hamano, C., Hansen, D., Hansen, T., Hara, P., Harrison, B., Hartfiel, M., Hartz, T., Haruyama, T., Hasegawa, N., Hasting, S., Hasting, A., Hatzikouteli, K., Hayashi, Y., Hayato, C., Hearty, R., Helmer, R., Henderson, N., Higashi, J., Hignight, E., Hirose, J., Holeczek, S., Horikawa, A., Hyndman, A., Ichikawa, K., Ieki, M., Ieva, M., Iida, M., Ikeda, J., Ilic, J., Imber, T., Ishida, C., Ishihara, T., Ishii, S., Ive, M., Iwasaki, K., Iyogi, A., Izmaylov, B., Jamieson, R., Johnson, K., Joo, G., Jover Mana, C., Jung, H., Kaji, T., Kajita, H., Kakuno, J., Kameda, K., Kaneyuki, D., Karlen, K., Kasami, I., Kato, E., Kearn, M., Khabibullin, F., Khanam, A., Khotjantsev, D., Kielczewska, T., Kikawa, J., Kim, S., Kim, N., Kimura, B., Kirby, J., Kisiel, P., Kitching, T., Kobayashi, G., Kogan, S., Koike, A., Konaka, L., Kormo, A., Korzenev, K., Koseki, Y., Koshio, Y., Kouzuma, K., Kowalik, V., Kravtsov, I., Kreslo, W., Kropp, H., Kubo, Y., Kudenko, N., Kulkarni, R., Kurjata, T., Kutter, J., Lagoda, K., Laihem, M., Laveder, K., Lee, P., Le, J., Levy, C., Licciardi, I., Lim, T., Lindner, R., Litchfield, M., Lito, A., Longhin, G., Lopez, P., Loverre, L., Ludovici, T., Lux, M., Macaire, K., Mahn, Y., Makida, M., Malek, S., Manly, A., Marchionni, A., Marino, J., Marteau, J., Martin, T., Maruyama, T., Maryon, J., Marzec, P., Masliah, E., Mathie, C., Matsumura, K., Matsuoka, V., Matveev, K., Mavrokoridi, E., Mazzucato, N., Mccauley, K., Mcfarland, C., Mcgrew, T., Mclachlan, M., Messina, W., Metcalf, C., Metelko, M., Mezzetto, P., Mijakowski, C., Miller, A., Minamino, O., Mineev, S., Mine, A., Missert, G., Mituka, M., Miura, K., Mizouchi, L., Monfregola, F., Moreau, B., Morgan, S., Moriyama, A., Muir, A., Murakami, M., Murdoch, S., Murphy, J., Myslik, T., Nakadaira, M., Nakahata, T., Nakai, K., Nakajima, T., Nakamoto, K., Nakamura, S., Nakayama, T., Nakaya, D., Naple, M., Navin, B., Nelson, T., Nicholl, K., Nishikawa, H., Nishino, J., Nowak, M., Noy, Y., Obayashi, T., Ogitsu, H., Ohhata, T., Okamura, K., Okumura, T., Okusawa, S., Oser, M., Otani, R., Owen, Y., Oyama, T., Ozaki, M., Pac, Palladino, Vittorio, V., Paolone, P., Paul, D., Payne, G., Pearce, J., Perkin, V., Pettinacci, F., Pierre, E., Poplawska, B., Popov, M., Posiadala, J. M., Poutissou, R., Poutissou, P., Przewlocki, W., Qian, J., Raaf, E., Radicioni, P., Ratoff, T., Raufer, M., Ravonel, M., Raymond, F., Retiere, A., Robert, P., Rodrigue, E., Rondio, J., Roney, B., Rossi, S., Roth, A., Rubbia, D., Ruterborie, S., Sabouri, R., Sacco, K., Sakashita, F., Sánchez, A., Sarrat, K., Sasaki, K., Scholberg, J., Schwehr, M., Scott, D., Scully, Y., Seiya, T., Sekiguchi, H., Sekiya, M., Shibata, Y., Shimizu, M., Shiozawa, S., Short, M., Siyad, R., Smith, M., Smy, J., Sobczyk, H., Sobel, M., Sorel, A., Stahl, P., Stamouli, J., Steinmann, B., Still, J., Stone, C., Strabel, L., Sulak, R., Sulej, P., Sutcliffe, A., Suzuki, K., Suzuki, S., Suzuki, Y., Suzuki, T., Szeglowski, M., Szeptycka, R., Tacik, M., Tada, S., Takahashi, A., Takeda, Y., Takenaga, Y., Takeuchi, K., Tanaka, H., Tanaka, M., Tanaka, N., Tanimoto, K., Tashiro, I., Taylor, A., Terashima, D., Terhorst, R., Terri, L., Thompson, A., Thorley, W., Toki, T., Tomaru, Y., Totsuka, C., Touramani, T., Tsukamoto, M., Tzanov, Y., Uchida, K., Ueno, A., Vacheret, M., Vagin, G., Vasseur, T., Wachala, J., Walding, A., Waldron, C., Walter, P., Wanderer, J., Wang, M., Ward, G., Ward, D., Wark, M., Wascko, A., Weber, R., Wendell, N., West, L., Whitehead, G., Wikström, R., Wilke, M., Wilking, J., Wilson, R., Wilson, T., Wongjirad, S., Yamada, Y., Yamada, A., Yamamoto, K., Yamamoto, Y., Yamanoi, H., Yamaoka, C., Yanagisawa, T., Yano, S., Yen, N., Yershov, M., Yokoyama, A., Zalewska, J., Zalipska, L., Zambelli, K., Zaremba, M., Ziembicki, E., Zimmerman, M., Zito, J., ??muda, and Walter, Christopher W
- Subjects
Particle physics ,FOS: Physical sciences ,General Physics and Astronomy ,ddc:500.2 ,CHOOZ ,01 natural sciences ,Particle identification ,High Energy Physics - Experiment ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,neutrino ,14.60.Pq, 13.15.+g, 25.30.Pt, 95.55.Vj ,0103 physical sciences ,neutrino oscillation ,Muon neutrino ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,Neutrino oscillation ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,ComputingMilieux_MISCELLANEOUS ,Physics ,NOνA ,Tribimaximal mixing ,hep-ex ,010308 nuclear & particles physics ,T2K experiment ,Física ,T2K Collaboration ,particle identification ,Electron neutrino ,experimental results - Abstract
The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumulated with $1.43\times10^{20}$ protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with $|\Delta m_{23}^2|=2.4\times10^{-3}$ eV$^2$, $\sin^2 2\theta_{23}=1$ and $\sin^2 2\theta_{13}=0$, the expected number of such events is 1.5$\pm$0.3(syst.). Under this hypothesis, the probability to observe six or more candidate events is 7$\times10^{-3}$, equivalent to 2.5$\sigma$ significance. At 90% C.L., the data are consistent with 0.03(0.04)$, Comment: 20 pages, 6 figures, version published in PRL
- Published
- 2011
9. Measurements of forward proton production with incident protons and charged pions on nuclear targets at the CERN Proton Synchroton
- Author
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Jordi Burguet-Castell, G. Giannini, L. Tortora, S.A. Bunyatov, A. Blondel, M. G. Catanesi, M. Kirsanov, E. Tcherniaev, M. Mezzetto, U. Gastaldi, Domizia Orestano, R. Schroeter, G.D. Barr, N. G. Polukhina, V. Tereschenko, E. Di Capua, A. Bagulya, V. Palladino, P. Zucchelli, Ilya Tsukerman, G.P. Skoro, A. Artamonov, A. Guglielmi, C. Meurer, L. Coney, G. Vidal-Sitjes, A. Kayis-Topaksu, L. Howlett, J.S. Graulich, S. Gianì, M. Sorel, Ghislain Grégoire, A. Cervera-Villanueva, G. Prior, R. Tsenov, Rob Edgecock, Ioannis Papadopoulos, C. Wiebusch, M. Bonesini, A. Grossheim, V. Grichine, U. Dore, A. Grant, Claus Gößling, P. Gorbunov, Silvia Borghi, E. Radicioni, Simone Gilardoni, Alexey Krasnoperov, F. Pastore, Malcolm Ellis, A. Ivanchenko, M. Bogomilov, D. W. Schmitz, P. Novella, J. Martín-Albo, D. Gibin, J.J. Gómez-Cadenas, Petar Temnikov, J. Panman, D. Kolev, C. N. Booth, S. Piperov, J. Dumarchez, F. Ferri, Vladimir Ivanchenko, M. C. Morone, B. A. Popov, A. Tonazzo, M. Apollonio, P. Chimenti, F. Bobisut, G. B. Mills, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), HARP, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), UCL - SST/IRMP - Institut de recherche en mathématique et physique, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Çukurova Üniversitesi, M., Apollonio, A., Artamonov, A., Bagulya, G., Barr, A., Blondel, F., Bobisut, M., Bogomilov, M., Bonesini, C., Booth, S., Borghi, S., Bunyatov, J., Burguet Castell, M., Catanesi, A., Cervera Villanueva, P., Chimenti, L., Coney, E., Di Capua, U., Dore, J., Dumarchez, R., Edgecock, M., Elli, F., Ferri, U., Gastaldi, S., Giani, Giannini, Gianrossano, D., Gibin, S., Gilardoni, P., Gorbunov, C., Gößling, J., Gómez Cadena, A., Grant, J., Graulich, G., Grégoire, V., Grichine, A., Grossheim, A., Guglielmi, L., Howlett, A., Ivanchenko, V., Ivanchenko, A., Kayis Topaksu, M., Kirsanov, D., Kolev, A., Krasnoperov, J., Martín Albo, C., Meurer, M., Mezzetto, G., Mill, M., Morone, P., Novella, D., Orestano, V., Palladino, J., Panman, I., Papadopoulo, F., Pastore, S., Piperov, N., Polukhina, B., Popov, G., Prior, E., Radicioni, D., Schmitz, R., Schroeter, G., Skoro, M., Sorel, E., Tcherniaev, P., Temnikov, V., Tereschenko, A., Tonazzo, L., Tortora, R., Tsenov, I., Tsukerman, G., Vidal Sitje, C., Wiebusch, P., Zucchelli, Blondel, Alain, Borghi, Silvia, Morone, Maria Cristina, Prior, Gersende, Schroeter, Raphaël, Çukurova Üniversitesi, Fen-Edebiyat Fakültesi, Fizik Bölümü, Apollonio, M, Artamonov, A, Bagulya, A, Barr, G, Blondel, A, Bobisut, F, Bogomilov, M, Bonesini, M, Booth, C, Borghi, S, Bunyatov, S, Burguet Castell, J, Catanesi, Mg, Cervera Villanueva, A, Chimenti, P, Coney, L, Di Capua, E, Dore, U, Dumarchez, J, Edgecock, R, Ellis, M, Ferri, F, Gastaldi, U, Giani, S, Giannini, G, Gibin, D, Gilardoni, S, Gorbunov, P, Gossling, C, Gomez Cadenas, Jj, Grant, A, Graulich, J, Gregoire, G, Grichine, V, Grossheim, A, Guglielmi, A, Howlett, L, Ivanchenko, A, Ivanchenko, V, Kayis Topaksu, A, Kirsanov, M, Kolev, D, Krasnoperov, A, Martin Albo, J, Meurer, C, Mezzetto, M, Mills, Gb, Morone, Mc, Novella, P, Orestano, Domizia, Palladino, V, Panman, J, Papadopoulos, I, Pastore, F, Piperov, S, Polukhina, N, Popov, B, Prior, G, Radicioni, E, Schmitz, D, Schroeter, R, Skoro, G, Sorel, M, Tcherniaev, E, Temnikov, P, Tereschenko, V, Tonazzo, A, Tortora, L, Tsenov, R, Tsukerman, I, Vidal Sitjes, G, Wiebusch, C, and Zucchelli, P.
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Nuclear and High Energy Physics ,[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,Physics::Instrumentation and Detectors ,proton ,nuclear targets ,charged pions ,FOS: Physical sciences ,ddc:500.2 ,01 natural sciences ,High Energy Physics - Experiment ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Basic research ,0103 physical sciences ,CERN ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,010306 general physics ,Nuclear Experiment ,Inelastic proton scattering ,Physics ,Large Hadron Collider ,010308 nuclear & particles physics ,Other reactions above meson production thresholds ,[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,Física ,Pion-induced reactions ,Research council ,nuclear target ,Physics::Accelerator Physics ,HARP Experiment ,High Energy Physics::Experiment ,Humanities ,Particle Physics - Experiment - Abstract
Measurements of the double-differential proton production cross-section d(2 sigma)/dpd Omega in the range of momentum 0.5 GeV/c, We gratefully acknowledge the help and support of the PS beam staff and of the numerous technical collaborators who contributed to the detector design, construction, commissioning and operation. In particular, we would like to thank G. Barichello, R. Brocard, K. Burin, V. Carassiti, F. Chignoli, D. Conventi, G. Decreuse, M. Delattre, C. Detraz, A. Domeniconi, M. Dwuznik, F. Evangelisti, B. Friend, A. Iaciofano, I. Krasin, D. Lacroix, J.-C. Legrand, M. Lobello, M. Lollo, J. Loquet, F. Marinilli, R. Mazza, J. Mulon, L. Musa, R. Nicholson, A. Pepato, P. Petev, X. Pons, I. Rusinov, M. Scandurra, E. Usenko, R. van der Vlugt, for their support in the construction of the detector and P. Dini for his contribution to Monte Carlo production. The collaboration acknowledges the major contributions and advice of M. Baldo-Ceolin, L. Linssen, M.T. Muciaccia and A. Pullia during the construction of the experiment. The collaboration is indebted to V. Ableev, F. Bergsma, P. Binko, E. Boter,M. Calvi, C. Cavion,M.Chizov, A. Chukanov, A. DeSanto, A. DeMin, M. Doucet, D. D¨ullmann, V. Ermilova, W. Flegel, Y. Hayato, A. Ichikawa, O. Klimov, T. Kobayashi, D. Kustov, M. Laveder, M. Mass, H. Meinhard, A. Menegolli, T. Nakaya, K. Nishikawa, M. Paganoni, F. Paleari, M. Pasquali, M. Placentino, V. Serdiouk, S. Simone, P.J. Soler, S. Troquereau, S. Ueda, A. Valassi and R. Veenhof for their contributions to the experiment. We acknowledge the contributions of V. Ammosov, G. Chelkov, D. Dedovich, F. Dydak, M. Gostkin, A. Guskov, D. Khartchenko, V. Koreshev, Z. Kroumchtein, I. Nefedov, A. Semak, J. Wotschack, V. Zaets and A. Zhemchugov to the work described in this paper. The experiment was made possible by grants from the Institut Interuniversitaire des Sciences Nucléaires and the Interuniversitair Instituut voor Kernwetenschappen (Belgium), Ministerio de Educación y Ciencia, Grant FPA2003-06921-c02-02 and Generalitat Valenciana, grant GV00-054-1, CERN (Geneva, Switzerland), the German Bundesministerium für Bildung und Forschung (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), INR RAS (Moscow), the Russian Foundation for Basic Research (grant 08-02-00018), the Bulgarian Mational Science Fund (contract VU-F- 205/2006) and the Particle Physics and Astronomy Research Council (UK). We gratefully acknowledge their support.
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- 2010
10. Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models.
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Antonosante A, Castelli V, Sette M, Alfonsetti M, Catanesi M, Benedetti E, Ardini M, Cimini A, and d'Angelo M
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- Animals, Mice, Oxidopamine, Proteasome Endopeptidase Complex, PPAR-beta, Neuroprotective Agents pharmacology, Parkinson Disease drug therapy
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Background: The underlying mechanism of Parkinson's disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are transcription factors involved in the control of numerous pathways. Specifically, PPARβ/δ is recognized as an oxidative stress sensor, and we have previously reported that it plays a detrimental role in neurodegeneration., Methods: Basing on this concept, in this work, we tested the potential effects of a specific PPARβ/δ antagonist (GSK0660) in an in vitro model of Parkinson's disease. Specifically, live-cell imaging, gene expression, Western blot, proteasome analyses, mitochondrial and bioenergetic studies were performed. Since we obtained promising results, we tested this antagonist in a 6-hydroxydopamine hemilesioned mouse model. In the animal model, behavioral tests, histological analysis, immunofluorescence and western blot of substantia nigra and striatum upon GSK0660 were assayed., Results: Our findings suggested that PPARβ/δ antagonist has neuroprotective potential due to neurotrophic support, anti-apoptotic and anti-oxidative effects paralleled to an amelioration of mitochondria and proteasome activity. These findings are strongly supported also by the siRNA results demonstrating that by silencing PPARβ/δ a significative rescue of the dopaminergic neurons was obtained, thus indicating an involvement of PPARβ/δ in PD's pathogenesis. Interestingly, in the animal model, GSK0660 treatment confirmed neuroprotective effects observed in the in vitro studies. Neuroprotective effects were highlighted by the behavioural performance and apomorphine rotation tests amelioration and the reduction of dopaminergic neuronal loss. These data were also confirmed by imaging and western blotting, indeed, the tested compound decreased astrogliosis and activated microglia, concomitant with an upregulation of neuroprotective pathways., Conclusions: In summary, PPARβ/δ antagonist displayed neuroprotective activities against 6-hydroxydopamine detrimental effects both in vitro and in vivo models of Parkinson's disease, suggesting that it may represent a novel therapeutic approach for this disorder., (© 2023. The Author(s).)
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- 2023
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11. Differential Effects of Nonsteroidal Anti-Inflammatory Drugs in an In Vitro Model of Human Leaky Gut.
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d'Angelo M, Brandolini L, Catanesi M, Castelli V, Giorgio C, Alfonsetti M, Tomassetti M, Zippoli M, Benedetti E, Cesta MC, Colagioia S, Cocchiaro P, Cimini A, and Allegretti M
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- Humans, Ibuprofen pharmacology, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Oxidative Stress, Ketoprofen
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The intestinal barrier is the main contributor to gut homeostasis. Perturbations of the intestinal epithelium or supporting factors can lead to the development of intestinal hyperpermeability, termed "leaky gut". A leaky gut is characterized by loss of epithelial integrity and reduced function of the gut barrier, and is associated with prolonged use of Non-Steroidal Anti-Inflammatories. The harmful effect of NSAIDs on intestinal and gastric epithelial integrity is considered an adverse effect that is common to all drugs belonging to this class, and it is strictly dependent on NSAID properties to inhibit cyclo-oxygenase enzymes. However, different factors may affect the specific tolerability profile of different members of the same class. The present study aims to compare the effects of distinct classes of NSAIDs, such as ketoprofen (K), Ibuprofen (IBU), and their corresponding lysine (Lys) and, only for ibuprofen, arginine (Arg) salts, using an in vitro model of leaky gut. The results obtained showed inflammatory-induced oxidative stress responses, and related overloads of the ubiquitin-proteasome system (UPS) accompanied by protein oxidation and morphological changes to the intestinal barrier, many of these effects being counteracted by ketoprofen and ketoprofen lysin salt. In addition, this study reports for the first time a specific effect of R-Ketoprofen on the NFkB pathway that sheds new light on previously reported COX-independent effects, and that may account for the observed unexpected protective effect of K on stress-induced damage on the IEB.
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- 2023
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12. An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration.
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Tupone MG, Panella G, d'Angelo M, Castelli V, Caioni G, Catanesi M, Benedetti E, and Cimini A
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- Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Humans, Nerve Regeneration drug effects, Regenerative Medicine, Tissue Engineering, Central Nervous System physiology, Graphite chemistry, Nanostructures chemistry
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Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity, allowing to study, and educate neural connections, and guide neural growth and differentiation; thus, graphene-based nanomaterials represent an emerging aspect in regenerative medicine. Moreover, there is now an urgent need to develop multifunctional and functionalized nanomaterials able to arrive at neuronal cells through the blood-brain barrier, to manage a specific drug delivery system. In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields of nervous tissue engineering and neural regenerative medicine. We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications.
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- 2021
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13. S-Carboxymethyl Cysteine Protects against Oxidative Stress and Mitochondrial Impairment in a Parkinson's Disease In Vitro Model.
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Catanesi M, Brandolini L, d'Angelo M, Tupone MG, Benedetti E, Alfonsetti M, Quintiliani M, Fratelli M, Iaconis D, Cimini A, Castelli V, and Allegretti M
- Abstract
The mucolytic agent S-carboxymethylcysteine is widely used as an expectorant for the treatment of numerous respiratory disorders. The metabolic fate of S-carboxymethyl-L-cysteine is complex. Several clinical studies have demonstrated that the metabolism of this agent differs within the same individual, with sulfur oxygenated metabolites generated upon night-time administration. It has been indicated that this drug behaves like a free radical scavenger and that, in this regard, the sulfide is the active species with sulphoxide metabolites (already oxidized) being inactive. Consequently, a night-time consumption of the drug should be more effective upon daytime administration. Still, this diurnal variation in biotransformation (deactivation) is dependent on the genetic polymorphism on which relies the patient population capacities of S-carboxymethyl-L-cysteine sulphoxidation. It has been reported that those cohorts who are efficient sulfur oxidizers will generate inactive oxygenated metabolites. In contrast, those who have a relative deficiency in this mechanism will be subjected to the active sulfide for a more extended period. In this regard, it is noteworthy that 38-39% of Parkinson's disease patients belong to the poor sulphoxide cohort, being exposed to higher levels of active sulfide, the active antioxidant metabolite of S-carboxymethyl-L-cysteine. Parkinson's disease is a neurodegenerative disorder that affects predominately dopaminergic neurons. It has been demonstrated that oxidative stress and mitochondrial dysfunction play a crucial role in the degeneration of dopaminergic neurons. Based on this evidence, in this study, we evaluated the effects of S-carboxymethyl cysteine in an in vitro model of Parkinson's disease in protecting against oxidative stress injury. The data obtained suggested that an S-carboxymethylcysteine-enriched diet could be beneficial during aging to protect neurons from oxidative imbalance and mitochondrial dysfunction, thus preventing the progression of neurodegenerative processes.
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- 2021
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14. L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease.
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Catanesi M, Brandolini L, d'Angelo M, Benedetti E, Tupone MG, Alfonsetti M, Cabri E, Iaconis D, Fratelli M, Cimini A, Castelli V, and Allegretti M
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Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and the biosynthesis of glutathione to counteract oxidative stress. Still, methionine restriction avoids altered methionine/transmethylation metabolism, thus reducing DNA damage and possibly avoiding neurodegenerative processes. In this study, we wanted to study the preventive effects of methionine in counteracting 6-hydroxydopamine (6-OHDA)-induced injury. In particular, we analyzed the protective effects of the amino acid L-methionine in an in vitro model of Parkinson's disease and dissected the underlying mechanisms compared to the known antioxidant taurine to gain insights into the potential of methionine treatment in slowing the progression of the disease by maintaining mitochondrial functionality. In addition, to ascribe the effects of methionine on mitochondria and oxidative stress, methionine sulfoxide was used in place of methionine. The data obtained suggested that an L-methionine-enriched diet could be beneficial during aging to protect neurons from oxidative imbalance and mitochondrial dysfunction, thus preventing the progression of neurodegenerative processes.
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- 2021
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15. A State-of-the-Art of Functional Scaffolds for 3D Nervous Tissue Regeneration.
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Tupone MG, d'Angelo M, Castelli V, Catanesi M, Benedetti E, and Cimini A
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Exploring and developing multifunctional intelligent biomaterials is crucial to improve next-generation therapies in tissue engineering and regenerative medicine. Recent findings show how distinct characteristics of in situ microenvironment can be mimicked by using different biomaterials. In vivo tissue architecture is characterized by the interconnection between cells and specific components of the extracellular matrix (ECM). Last evidence shows the importance of the structure and composition of the ECM in the development of cellular and molecular techniques, to achieve the best biodegradable and bioactive biomaterial compatible to human physiology. Such biomaterials provide specialized bioactive signals to regulate the surrounding biological habitat, through the progression of wound healing and biomaterial integration. The connection between stem cells and biomaterials stimulate the occurrence of specific modifications in terms of cell properties and fate, influencing then processes such as self-renewal, cell adhesion and differentiation. Recent studies in the field of tissue engineering and regenerative medicine have shown to deal with a broad area of applications, offering the most efficient and suitable strategies to neural repair and regeneration, drawing attention towards the potential use of biomaterials as 3D tools for in vitro neurodevelopment of tissue models, both in physiological and pathological conditions. In this direction, there are several tools supporting cell regeneration, which associate cytokines and other soluble factors delivery through the scaffold, and different approaches considering the features of the biomaterials, for an increased functionalization of the scaffold and for a better promotion of neural proliferation and cells-ECM interplay. In fact, 3D scaffolds need to ensure a progressive and regular delivery of cytokines, growth factors, or biomolecules, and moreover they should serve as a guide and support for injured tissues. It is also possible to create scaffolds with different layers, each one possessing different physical and biochemical aspects, able to provide at the same time organization, support and maintenance of the specific cell phenotype and diversified ECM morphogenesis. Our review summarizes the most recent advancements in functional materials, which are crucial to achieve the best performance and at the same time, to overcome the current limitations in tissue engineering and nervous tissue regeneration., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Tupone, d’Angelo, Castelli, Catanesi, Benedetti and Cimini.)
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- 2021
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16. PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress.
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Castelli V, Catanesi M, Alfonsetti M, Laezza C, Lombardi F, Cinque B, Cifone MG, Ippoliti R, Benedetti E, Cimini A, and d'Angelo M
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Breast cancer is the most frequent cancer and the second leading cause of death among women. Triple-negative breast cancer is the most aggressive subtype of breast cancer and is characterized by the absence of hormone receptors and human epithelial growth factor receptor 2. Cancer stem cells (CSCs) represent a small population of tumor cells showing a crucial role in tumor progression, metastasis, recurrence, and drug resistance. The presence of CSCs can explain the failure of conventional therapies to completely eradicate cancer. Thus, to overcome this limit, targeting CSCs may constitute a promising approach for breast cancer treatment, especially in the triple-negative form. To this purpose, we isolated and characterized breast cancer stem cells from a triple-negative breast cancer cell line, MDA-MB-231. The obtained mammospheres were then treated with the specific PPARα antagonist GW6471, after which, glucose, lipid metabolism, and invasiveness were analyzed. Notably, GW6471 reduced cancer stem cell viability, proliferation, and spheroid formation, leading to apoptosis and metabolic impairment. Overall, our findings suggest that GW6471 may be used as a potent adjuvant for gold standard therapies for triple-negative breast cancer, opening the possibility for preclinical and clinical trials for this class of compounds.
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- 2021
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17. Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders.
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Catanesi M, Caioni G, Castelli V, Benedetti E, d'Angelo M, and Cimini A
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- Alzheimer Disease drug therapy, Animals, Antioxidants chemistry, Antioxidants pharmacology, Humans, Neuroprotective Agents therapeutic use, Parkinson Disease drug therapy, Aquatic Organisms chemistry, Marine Biology, Neurodegenerative Diseases drug therapy
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Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs' neuroprotective potential for neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. We will describe these marine compounds' potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.
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- 2021
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18. Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death.
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Castelli V, Melani F, Ferri C, d'Angelo M, Catanesi M, Grassi D, Benedetti E, Giordano A, Cimini A, and Desideri G
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Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H
2 O2 in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and vitamin B12 were used alone or in combination in human neuronal differentiated SH-SY5Y cells upon hydrogen peroxide-induced injury and neuroprotective, neuronal death pathways were analyzed. The nutraceuticals analyzed were able to protect H2 O2 cytotoxic effects, through increasing cell viability and proteins involved in neuroprotection pathways and restoring proteins involved in cell death pathways. On this basis, it is possible to propose the use of these compounds as dietary supplement for the prevention or as adjuvant to the only symptomatic treatments so far available for neurodegenerative diseases., (© 2020 Wiley Periodicals LLC.)- Published
- 2020
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19. MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases.
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Catanesi M, d'Angelo M, Tupone MG, Benedetti E, Giordano A, Castelli V, and Cimini A
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- Apoptosis genetics, Apoptosis physiology, Gene Expression Regulation, Humans, Mitochondria metabolism, Mitochondria pathology, Neurodegenerative Diseases metabolism, Neurodegenerative Diseases pathology, Reactive Oxygen Species metabolism, Aging genetics, MicroRNAs genetics, Mitochondria genetics, Neurodegenerative Diseases genetics
- Abstract
Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying these disorders are essential to develop therapeutic approaches. MicroRNAs (miRNAs) are short non-coding RNAs implicated in gene expression regulation at the post-transcriptional level. Moreover, miRNAs are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. Altered miRNAs levels have been associated with the formation of reactive oxygen species (ROS) and mitochondrial dysfunction. Mitochondrial dysfunction and ROS formation occur in many neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. The crosstalk existing among oxidative stress, mitochondrial dysfunction and miRNAs dysregulation plays a pivotal role in the onset and progression of neurodegenerative diseases. Based on this evidence, in this review, with a focus on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets.
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- 2020
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20. Neuroprotective potential of choline alfoscerate against β-amyloid injury: Involvement of neurotrophic signals.
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Catanesi M, d'Angelo M, Antonosante A, Castelli V, Alfonsetti M, Benedetti E, Desideri G, Ferri C, and Cimini A
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- Amyloid beta-Peptides toxicity, Apoptosis drug effects, Brain-Derived Neurotrophic Factor metabolism, Cell Differentiation, Cell Line, Tumor, Cell Survival drug effects, Humans, Neurons cytology, Neurons drug effects, Peptide Fragments toxicity, Receptor, trkB metabolism, Signal Transduction, Alzheimer Disease metabolism, Glycerylphosphorylcholine pharmacology, Neuroprotective Agents pharmacology
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Alzheimer's disease represents the most prevalent neurodegeneration worldwide, clinically characterized by cognitive and memory impairment. New therapeutic approaches are extremely important to counteract this disorder. This research is focused on the potential use of choline alfoscerate in preventing neuronal death using in vitro models of Alzheimer's disease, representing the early stage of the disease, treated before or after the insult with glycerylphosphorylcholine. On the light of the results collected, we can postulate that choline alfoscerate, by the activation of the neurotrophin survival pathway, was able to counteract the detrimental effect of β-amyloid in both in vitro models, reducing apoptotic cell death and preserving the neuronal morphology., (© 2020 International Federation for Cell Biology.)
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- 2020
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21. Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson's disease models.
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Castelli V, d'Angelo M, Lombardi F, Alfonsetti M, Antonosante A, Catanesi M, Benedetti E, Palumbo P, Cifone MG, Giordano A, Desideri G, and Cimini A
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- Animals, Behavior, Animal drug effects, Cell Line, Tumor, Disease Models, Animal, Humans, Male, Mice, Probiotics administration & dosage, Gastrointestinal Microbiome drug effects, Motor Skills drug effects, Parkinson Disease, Secondary drug therapy, Probiotics therapeutic use
- Abstract
Parkinson is a common neurodegenerative disorder, characterized by motor and non-motor symptoms, including abnormalities in the gut function, which may appear before the motor sign. To date, there are treatments that can help relieve Parkinson' disease (PD)-associated symptoms, but there is no cure to control the onset and progression of this disorder. Altered components of the gut could represent a key role in gut-brain axis, which is a bidirectional system between the central nervous system and the enteric nervous system. Diet can alter the microbiota composition, affecting gut-brain axis function. Gut microbiome restoration through selected probiotics' administration has been reported. In this study, we investigated the effects of the novel formulation SLAB51 in PD. Our findings indicate that this probiotic formulation can counteract the detrimental effect of 6-OHDA in vitro and in vivo models of PD. The results suggest that SLAB51 can be a promising candidate for the prevention or as coadjuvant treatment of PD.
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- 2020
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22. Corrigendum: Theranostic Nanomedicine for Malignant Gliomas.
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d'Angelo M, Castelli V, Benedetti E, Antonosante A, Catanesi M, Dominguez-Benot R, Pitari G, Ippoliti R, and Cimini A
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[This corrects the article DOI: 10.3389/fbioe.2019.00325.]., (Copyright © 2020 d'Angelo, Castelli, Benedetti, Antonosante, Catanesi, Dominguez-Benot, Pitari, Ippoliti and Cimini.)
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- 2020
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23. Theranostic Nanomedicine for Malignant Gliomas.
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d'Angelo M, Castelli V, Benedetti E, Antonosante A, Catanesi M, Dominguez-Benot R, Pitari G, Ippoliti R, and Cimini A
- Abstract
Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described., (Copyright © 2019 d'Angelo, Castelli, Benedetti, Antonosante, Catanesi, Dominguez-Benot, Pitari, Ippoliti and Cimini.)
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- 2019
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24. Lifestyle and Food Habits Impact on Chronic Diseases: Roles of PPARs.
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d'Angelo M, Castelli V, Tupone MG, Catanesi M, Antonosante A, Dominguez-Benot R, Ippoliti R, Cimini AM, and Benedetti E
- Subjects
- Animals, Chronic Disease, Energy Metabolism, Humans, Protein Isoforms metabolism, Feeding Behavior, Inflammation metabolism, Life Style, Metabolic Syndrome metabolism, Peroxisome Proliferator-Activated Receptors metabolism
- Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that exert important functions in mediating the pleiotropic effects of diverse exogenous factors such as physical exercise and food components. Particularly, PPARs act as transcription factors that control the expression of genes implicated in lipid and glucose metabolism, and cellular proliferation and differentiation. In this review, we aim to summarize the recent advancements reported on the effects of lifestyle and food habits on PPAR transcriptional activity in chronic disease.
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- 2019
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25. PPARγ and Cognitive Performance.
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d'Angelo M, Castelli V, Catanesi M, Antonosante A, Dominguez-Benot R, Ippoliti R, Benedetti E, and Cimini A
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- Animals, Autistic Disorder genetics, Cognition Disorders genetics, Humans, PPAR gamma genetics, Parkinson Disease genetics, Schizophrenia genetics, Autistic Disorder metabolism, Cognition, Cognition Disorders metabolism, PPAR gamma metabolism, Parkinson Disease metabolism, Schizophrenia metabolism
- Abstract
Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed.
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- 2019
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- View/download PDF
26. The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration.
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d'Angelo M, Benedetti E, Tupone MG, Catanesi M, Castelli V, Antonosante A, and Cimini A
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- Animals, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Humans, Mechanotransduction, Cellular, Stem Cells drug effects, Stem Cells physiology, Cellular Reprogramming, Regeneration, Stem Cells cytology, Tissue Scaffolds chemistry
- Abstract
The mechanotransduction is the process by which cells sense mechanical stimuli such as elasticity, viscosity, and nanotopography of extracellular matrix and translate them into biochemical signals. The mechanotransduction regulates several aspects of the cell behavior, including migration, proliferation, and differentiation in a time-dependent manner. Several reports have indicated that cell behavior and fate are not transmitted by a single signal, but rather by an intricate network of many signals operating on different length and timescales that determine cell fate. Since cell biology and biomaterial technology are fundamentals in cell-based regenerative therapies, comprehending the interaction between cells and biomaterials may allow the design of new biomaterials for clinical therapeutic applications in tissue regeneration. In this work, we present the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time.
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- 2019
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27. DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain.
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Brandolini L, Castelli V, Aramini A, Giorgio C, Bianchini G, Russo R, De Caro C, d'Angelo M, Catanesi M, Benedetti E, Giordano A, Cimini A, and Allegretti M
- Subjects
- Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cytokines metabolism, Humans, Molecular Targeted Therapy, Neuralgia prevention & control, Oxaliplatin adverse effects, Oxaliplatin therapeutic use, Antineoplastic Agents adverse effects, Interleukin-8 metabolism, Neuralgia etiology, Neuralgia metabolism, Signal Transduction drug effects
- Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of several anti-neoplastics and a main cause of sensory disturbances in cancer survivors, negatively impacting patients' quality of life. Peripheral nerve degeneration or small fibre neuropathy is generally accepted as the underlying mechanism in the development of CIPN. Recent evidence has contributed to clarify the determinant role of cytokines and chemokines in the process leading to neuronal hyperexcitability. Exposure to oxaliplatin triggers alterations in peripheral neuropathic pathways previously linked to IL-8 pathway. We investigated a novel selective inhibitor of IL-8 receptors, DF2726A, and showed its effects in counteracting CINP pathways, extending the relevance of the activation of IL-8 pathway to the class of platinum chemotherapeutics. Based on our results, we suggest that DF2726A might be a promising candidate for clinical treatment of CIPN conditions due to its efficacy and optimized pharmacokinetic/pharmacodynamic profile.
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- 2019
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28. Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic.
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Castelli V, Benedetti E, Antonosante A, Catanesi M, Pitari G, Ippoliti R, Cimini A, and d'Angelo M
- Abstract
Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges, resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative disorders, these mechanisms are compromised. In fact, neurons show unique age-related changes in functions and metabolism, resulting in greater susceptibility to insults and disease. Aging affects the nervous system as well as other organs. More precisely, as the nervous system ages, neuron metabolism may change, inducing glucose hypometabolism, impaired transport of critical substrates underlying metabolism, alterations in calcium signaling, and mitochondrial dysfunction. Moreover, in neuronal aging, an accumulation of impaired and aggregated proteins in the cytoplasm and in mitochondria is observed, as the result of oxidative stress: reduced antioxidant defenses and/or increase of reactive oxygen species (ROS). These changes lead to greater vulnerability of neurons in various regions of the brain and increased susceptibility to several diseases. Specifically, the first part of the review article will focus on the major neuronal cells' rearrangements during aging in response to changes in metabolism and oxidative stress, while the second part will cover the neurodegenerative disease areas in detail.
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- 2019
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29. YAP/TAZ mechano-transduction as the underlying mechanism of neuronal differentiation induced by reduced graphene oxide.
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Catanesi M, Panella G, Benedetti E, Fioravanti G, Perrozzi F, Ottaviano L, Leandro LD, Ardini M, Giansanti F, d'Angelo M, Castelli V, Angelucci F, Ippoliti R, and Cimini A
- Subjects
- Acyltransferases, Cell Differentiation, Cell Line, Humans, Neurons cytology, Oxidation-Reduction, Signal Transduction, Surface Properties, YAP-Signaling Proteins, Adaptor Proteins, Signal Transducing metabolism, Graphite metabolism, Mechanotransduction, Cellular physiology, Neurons metabolism, Phosphoproteins metabolism, Transcription Factors metabolism
- Abstract
Aim: The aim of this work is the dissection of the molecular pathways underlying the differentiation effect of reduced graphene oxide (GO) materials in the absence of differentiation agents., Materials & Methods: Reduced GO is obtained either by drop casting method and heat-treated or biological reduction by the interaction between GO and wtPrxI. Cells were grown on both materials and the differentiation process studied by immunological and morphological detection., Results & Conclusion: The results obtained indicate that both reduction methods of GO can determine the modulation of pathway involved in mechano-transduction and differentiation, by affecting YAP/TAZ localization outside the nuclei and increasing neuronal differentiation markers. This suggests that the mechano-transduction pathways are responsible for the differentiation process.
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- 2018
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30. The Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells.
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Antonosante A, d'Angelo M, Castelli V, Catanesi M, Iannotta D, Giordano A, Ippoliti R, Benedetti E, and Cimini A
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- Animals, Energy Metabolism genetics, Energy Metabolism physiology, Humans, Neoplasms genetics, Peroxisome Proliferator-Activated Receptors genetics, Receptors, Cytoplasmic and Nuclear genetics, Receptors, Cytoplasmic and Nuclear metabolism, Neoplasms metabolism, Peroxisome Proliferator-Activated Receptors metabolism
- Abstract
Energy homeostasis is crucial for cell fate, since all cellular activities are strongly dependent on the balance between catabolic and anabolic pathways. In particular, the modulation of metabolic and energetic pathways in cancer cells has been discussed in some reports, but subsequently has been neglected for a long time. Meanwhile, over the past 20 years, a recovery of the study regarding cancer metabolism has led to an increasing consideration of metabolic alterations in tumors. Cancer cells must adapt their metabolism to meet their energetic and biosynthetic demands, which are associated with the rapid growth of the primary tumor and colonization of distinct metastatic sites. Cancer cells are largely dependent on aerobic glycolysis for their energy production, but are also associated with increased fatty acid synthesis and increased rates of glutamine consumption. In fact, emerging evidence has shown that therapeutic resistance to cancer treatment may arise from the deregulation of glucose metabolism, fatty acid synthesis, and glutamine consumption. Cancer cells exhibit a series of metabolic alterations induced by mutations that lead to a gain-of-function of oncogenes, and a loss-of-function of tumor suppressor genes, including increased glucose consumption, reduced mitochondrial respiration, an increase of reactive oxygen species, and cell death resistance; all of these are responsible for cancer progression. Cholesterol metabolism is also altered in cancer cells and supports uncontrolled cell growth. In this context, we discuss the roles of peroxisome proliferator-activated receptors (PPARs), which are master regulators of cellular energetic metabolism in the deregulation of the energetic homeostasis, which is observed in cancer. We highlight the different roles of PPAR isotypes and the differential control of their transcription in various cancer cells.
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- 2018
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31. PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation.
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D'Angelo M, Antonosante A, Castelli V, Catanesi M, Moorthy N, Iannotta D, Cimini A, and Benedetti E
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- Animals, Humans, Neurodegenerative Diseases pathology, Neurons metabolism, Adaptation, Physiological, Cell Differentiation, Energy Metabolism, Neurogenesis, Neurons cytology, Peroxisome Proliferator-Activated Receptors metabolism
- Abstract
Peroxisome proliferator activated receptors (PPARs) are a class of ligand-activated transcription factors, belonging to the superfamily of receptors for steroid and thyroid hormones, retinoids, and vitamin D. PPARs control the expression of several genes connected with carbohydrate and lipid metabolism, and it has been demonstrated that PPARs play important roles in determining neural stem cell (NSC) fate. Lipogenesis and aerobic glycolysis support the rapid proliferation during neurogenesis, and specific roles for PPARs in the control of different phases of neurogenesis have been demonstrated. Understanding the changes in metabolism during neuronal differentiation is important in the context of stem cell research, neurodegenerative diseases, and regenerative medicine. In this review, we will discuss pivotal evidence that supports the role of PPARs in energy metabolism alterations during neuronal maturation and neurodegenerative disorders.
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- 2018
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32. Probiotic DSF counteracts chemotherapy induced neuropathic pain.
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Castelli V, Palumbo P, d'Angelo M, Moorthy NK, Antonosante A, Catanesi M, Lombardi F, Iannotta D, Cinque B, Benedetti E, Ippoliti R, Cifone MG, and Cimini A
- Abstract
Problem Statement: Chemotherapy-induced peripheral neuropathy (CIPN) is a widespread and potentially disabling side effect of various anticancer drugs. In spite of the intensive research focused on obtaining therapies capable to treat or prevent CIPN, the medical demand remains very high. Microtubule-stabilizing agents, among which taxanes, are effective chemotherapeutic agents for the therapy of several oncologic diseases. The inflammatory process activated by chemotherapeutic agents has been interpreted as a potential trigger of the nociceptive process in CIPN. The chemotherapy-driven release of proinflammatory and chemokines has been recognized as one of the principal mechanisms controlling the establishment of CIPN. Several reports have indicated that probiotics are capable to regulate the balance of anti-inflammatory and pro-inflammatory cytokines. Accordingly, it has been suggested that some probiotic formulations, may have an effective role in the management of inflammatory pain symptoms. Experimental approaches used: we tested the hypothesis that paclitaxel-induced neuropathic pain can be counteracted by the probiotic DSF by using an in vitro model of sensitive neuron, the F11 cells. On this model, the biomolecular pathways involved in chemotherapy induced peripheral neuropathy depending on inflammatory cytokines were investigated by Real-time PCR, Western blotting and confocal microscopy. General conclusions: the results obtained, i.e. the increase of acetylated tubulin, the increase of the active forms of proteins involved in the establishment of neuropathic pain, point towards the use of this probiotic formulation as a possible adjuvant agent for counteracting CINP symptoms., Competing Interests: CONFLICTS OF INTEREST None.
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- 2018
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33. Differential protein modulation by ketoprofen and ibuprofen underlines different cellular response by gastric epithelium.
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Brandolini L, d'Angelo M, Antonosante A, Villa S, Cristiano L, Castelli V, Benedetti E, Catanesi M, Aramini A, Luini A, Parashuraman S, Mayo E, Giordano A, Cimini A, and Allegretti M
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal toxicity, Arginine toxicity, Cell Survival drug effects, Cytoprotection, Drug Combinations, Epithelial Cells metabolism, Epithelial Cells pathology, Gastric Mucosa metabolism, Gastric Mucosa pathology, Gene Expression Profiling methods, Gene Regulatory Networks drug effects, Humans, Ibuprofen toxicity, Ketoprofen pharmacology, Ketoprofen toxicity, Lysine pharmacology, Lysine toxicity, MCF-7 Cells, Oligonucleotide Array Sequence Analysis, Real-Time Polymerase Chain Reaction, Time Factors, Transcriptome drug effects, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Arginine pharmacology, Epithelial Cells drug effects, Ethanol toxicity, Gastric Mucosa drug effects, Ibuprofen pharmacology, Ketoprofen analogs & derivatives, Lysine analogs & derivatives
- Abstract
Ketoprofen L-lysine salt (KLS), is widely used due to its analgesic efficacy and tolerability, and L-lysine was reported to increase the solubility and the gastric tolerance of ketoprofen. In a recent report, L-lysine salification has been shown to exert a gastroprotective effect due to its specific ability to counteract the NSAIDs-induced oxidative stress and up-regulate gastroprotective proteins. In order to derive further insights into the safety and efficacy profile of KLS, in this study we additionally compared the effect of lysine and arginine, another amino acid counterion commonly used for NSAIDs salification, in control and in ethanol challenged human gastric mucosa model. KLS is widely used for the control of post-surgical pain and for the management of pain and fever in inflammatory conditions in children and adults. It is generally well tolerated in pediatric patients, and data from three studies in >900 children indicate that oral administration is well tolerated when administered for up to 3 weeks after surgery. Since only few studies have so far investigated the effect of ketoprofen on gastric mucosa maintenance and adaptive mechanisms, in the second part of the study we applied the cMap approach to compare ketoprofen-induced and ibuprofen-induced gene expression profiles in order to explore compound-specific targeted biological pathways. Among the several genes exclusively modulated by ketoprofen, our attention was particularly focused on genes involved in the maintenance of gastric mucosa barrier integrity (cell junctions, morphology, and viability). The hypothesis was further validated by Real-time PCR., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2018
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