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1. Clinical efficacy of implementing a Patient Blood Management (PBM) Protocol in joint replacement surgery: a retrospective cohort study in a national referral center

Author

M, Scardino, B, Di Matteo, A, De Angelis, G, Anzillotti, F, Martorelli, V, Simili, G, Monteleone, M, Bovio, F, Tasso, M E, Laino, T, Tommasini, V, Savevski, G, Grappiolo, E, Kon, and T, D'Amato

Abstract

The aging of population has dramatically broadened the total number of Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA) performed worldwide. To optimize the number of blood transfusions performed, a multimodal and multidisciplinary approach was introduced, called Patient Blood Management (PBM). The aim of the present retrospective study is to evaluate the feasibility and clinical outcomes of a PBM protocol applied in a national referral center for joint replacement surgery. Clinical reports of 9,635 patients undergoing primary THA or TKA, from 2014 to 2019, were screened. The trends of hemoglobin value at admission and at day 4 after surgery were analyzed. Furthermore, the trend of blood bags' requests and blood transfusions was longitudinally evaluated to assess the efficacy of our PBM protocol and its potential impact in reducing the length of stay in the hospital.In 2014, mean hemoglobin (Hb) levels at postoperative day 4 were 10.3 g/dl and 10.2 g/dl for TKA (unilateral and bilateral, respectively), and in 2019 were 11.3 g/dl and 11.6 g/dl (unilateral and bilateral, respectively, p=0.001). Total requested red blood cell (RBC) transfusions by each surgery over time have decreased for THA (277 in 2014 vs. 120 in 2019, p=0.001). A correlation matrix analysis between Hb level, body mass index (BMI), age, days spent in orthopedic (OR) ward and number of requested transfusions showed that RBC bags transfusions were related to the length of the hospital stay.A timely application of a PBM protocol in the perioperative period of TKA and THA was significantly associated to the reduction of blood transfusions and total length of hospital stay, with clear benefits for both the patients and the hospital.

Published
2023

2. A rapid recovery protocol for hip and knee replacement surgery: a report of the outcomes in a referral center

Author

F, Tasso, V, Simili, B, Di Matteo, G, Monteleone, F, Martorelli, A, De Angelis, T, D'Amato, M, Bovio, D, Altomare, G, Campofreda, M, Marcacci, and M, Scardino

Subjects
Arthroplasty, Replacement, Hip, Humans, Length of Stay, Arthroplasty, Replacement, Knee, Referral and Consultation, Retrospective Studies
Abstract

The number of joint replacements is expected to dramatically increase, and the optimization of the available resources is fundamental to maintain high clinical standards while providing an efficient treatment to an increasing number of patients. The present study describes the outcomes of the application of a rapid recovery (RR) protocol in a referral center for hip and knee replacement surgery.The medical records of every patient undergoing primary hip or knee replacement in 2019 were identified and all the relevant data were retrospectively extracted and compared to those of year 2016 (the last year before the onset of the rapid recovery protocol). The following outcomes were considered: 1) length of stay (LOS); 2) total number of TKR and THR; 3) pre- and post-operative subjective questionnaires; 4) NRS for pain at day 1 following surgery; 5) mean hemoglobin value at discharge; 6) number of blood transfusion performed; 7) complications following surgery.The mean LOS was significantly lower for patients managed through the rapid recovery protocol: 5.1 ± 1.4 days vs. 10.4 ± 2.3 days (p0.0001). The earlier discharge of patients promoted an overall increase in the total number of joint replacement procedures performed (2,806 in year 2019 vs. 2,236 in year 2016; p0.0001). Higher hemoglobin values at discharge were found in the RR group (10.6 ± 1.4 g/dl vs. 9.6 ± 1.2 g/dl, p = 0.049). No difference was observed in terms of clinical scores and overall complication rate.The application of a multimodal RR protocol for THR and TKR patients was able to reduce the length of stay and optimize the use of blood products, without increasing the risk of complications or jeopardizing the functional recovery.

Published
2022

3. Specie esotiche invasive di rilevanza unionale in Italia: aggiornamenti e integrazioni

Author

C. Montagnani, R. Gentili, G. Brundu, L. Celesti‐Grapow, G. Galasso, L. Lazzaro, S. Armeli Minicante, L. Carnevali, A. T. R. Acosta, E. Agrillo, A. Alessandrini, C. Angiolini, N. M. G. Ardenghi, I. Arduini, S. Armiraglio, F. Attorre, G. Bacchetta, S. Bagella, E. Barni, G. Barone, F. Bartolucci, A. Beretta, G. Berta, R. Bolpagni, I. Bona, G. Bonari, D. Bouvet, M. Bovio, I. Briozzo, G. Brusa, F. Buldrini, S. Buono, M. Burnelli, M. Carboni, E. Carli, F. Casella, M. Castello, R. M. Ceriani, K. Cianfaglione, M. Cicutto, F. Conti, D. Dagnino, G. Domina, E. Fanfarillo, S. Fascetti, A. Ferrario, G. Ferretti, B. Foggi, L. Gariboldi, C. Giancola, D. Gigante, R. Guarino, D. Iamonico, M. Iberite, M. Kleih, V. L. A. Laface, M. Latini, V. Lazzeri, V. Lozano, S. Magrini, A. Mainetti, F. Marinangeli, F. Martini, F. Masiero, M. Massimi, L. Mazzola, P. Medagli, M. Mugnai, C. M. Musarella, G. Nicolella, S. Orsenigo, S. Peccenini, L. Pedullà, E. V. Perrino, M. Plutino, L. Podda, L. Poggio, G. Posillipo, C. Proietti, F. Prosser, A. Ranfa, M. Rempicci, G. Rivieccio, E. S. Rodi, L. Rosati, G. Salerno, A. Santangelo, F. Scalari, A. Selvaggi, G. Spampinato, A. Stinca, C. Turcato, D. Viciani, M. Vidali, M. Villani, M. Vurro, R. P. Wagensommer, T. Wilhalm, S. Citterio, S. Armeli Minicante, L. Celesti-Grapow, G. Galasso, L. Lazzaro, C. Montagnani, G. Brundu, Montagnani, C., Gentili, R., Brundu, G., Celesti‐grapow, L., Galasso, G., Lazzaro, L., Armeli Minicante, S., Carnevali, L., Acosta, A. T. R., Agrillo, E., Alessandrini, A., Angiolini, C., Ardenghi, N. M. G., Arduini, I., Armiraglio, S., Attorre, F., Bacchetta, G., Bagella, S., Barni, E., Barone, G., Bartolucci, F., Beretta, A., Berta, G., Bolpagni, R., Bona, I., Bonari, G., Bouvet, D., Bovio, M., Briozzo, I., Brusa, G., Buldrini, F., Buono, S., Burnelli, M., Carboni, M., Carli, E., Casella, F., Castello, M., Ceriani, R. M., Cianfaglione, K., Cicutto, M., Conti, F., Dagnino, D., Domina, G., Fanfarillo, E., Fascetti, S., Ferrario, A., Ferretti, G., Foggi, B., Gariboldi, L., Giancola, C., Gigante, D., Guarino, R., Iamonico, D., Iberite, M., Kleih, M., Laface, V. L. A., Latini, M., Lazzeri, V., Lozano, V., Magrini, S., Mainetti, A., Marinangeli, F., Martini, F., Masiero, F., Massimi, M., Mazzola, L., Medagli, P., Mugnai, M., Musarella, C. M., Nicolella, G., Orsenigo, S., Peccenini, S., Pedullà, L., Perrino, E. V., Plutino, M., Podda, L., Poggio, L., Posillipo, G., Proietti, C., Prosser, F., Ranfa, A., Rempicci, M., Rivieccio, G., Rodi, E. S., Rosati, L., Salerno, G., Santangelo, A., Scalari, F., Selvaggi, A., Spampinato, G., Stinca, A., Turcato, C., Viciani, D., Vidali, M., Villani, M., Vurro, M., Wagensommer, R. P., Wilhalm, T., and Citterio, S.

Subjects
Italy, Invasive alien plant species, plant distribution, Invasive alien plant species, plant distribution, Italy, Invasive alien plant specie
Abstract

La Commissione Europea (CE) ha inserito ad oggi 36 taxa esotici vegetali nella lista delle specie esotiche invasive di rilevanza unionale ai sensi del Regolamento (UE) n. 1143/2014 del Parlamento Europeo e del Consiglio, recante disposizioni volte a prevenire e gestire l’introduzione e la diffusione delle specie esotiche invasive. La lista delle specie di rilevanza unionale viene periodicamente aggiornata e include quelle specie che rappresentano una grave minaccia per la biodiversità, ma anche per la salute dei cittadini e le attività economiche nei territori dell’Unione Europea e che necessitano di una gestione concertata a livello comunitario. La CE vigila sullo stato di ogni taxon grazie anche a periodiche rendicontazioni da parte dei paesi dell'Unione. In vista di tali report, tra il 2020 e il 2021 è stata definita e integrata la distribuzione di queste specie in Italia.

Published
2022

4. Notulae To The Italian Native Vascular Flora: 11

Author

Davide Dagnino, Nicole Hofmann, Roberto Marchianò, Goffredo Filibeck, Carmelo Maria Musarella, Fabrizio Bonali, Riccardo Pennesi, Lorenzo Lastrucci, Giacomo Mei, Giulio Ferretti, Flavio Menini, Agostino Brusco, Duilio Iamonico, Gianniantonio Domina, Gianluca Piovesan, Valentina Laface, Francesco Roma-Marzio, Antonio Pica, G. Barberis, M. Bovio, A. Gabellini, Laura Cancellieri, L. Gubellini, Paolo Marenzi, Leonardo Rosati, Marco Martignoni, Rossano Bolpagni, Carlo Argenti, Jacopo Lupoletti, Sandro Ballelli, Lorenzo Antonino Gianguzzi, Emanuele Del Guacchio, Gabriele Galasso, Marco Merli, Lorenzo Pinzani, Bruno Foggi, Gianluigi Bacchetta, Michele Lonati, Sarah Tonelli, Davide Barberis, Simone Ravetto Enri, Maurizio Trenchi, Luciana Carotenuto, Lina Podda, Marco Pittarello, Giovanni Spampinato, Enrico Banfi, Giuliano Campus, Emanuele Cheli, Fabrizio Bartolucci, Claudia Turcato, Adriano Stinca, Daniele Viciani, Orazio Caldarella, Domenico Lucarini, Emmanuele Farris, Sebastiano Andreatta, Gianni Bedini, Ian Briozzo, Simonetta Peccenini, Günter Gottschlich, Simone Orsenigo, Lorenzo Peruzzi, Bartolucci, F., Domina, G., Andreatta, S., Argenti, C., Bacchetta, G., Ballelli, S., Banfi, E., Barberis, D., Barberis, G., Bedini, G., Bolpagni, R., Bonali, F., Bovio, M., Briozzo, I., Brusco, A., Caldarella, O., Campus, G., Cancellieri, L., Carotenuto, L., Cheli, E., Dagnino, D., Guacchio, E. D., Farris, E., Ferretti, G., Filibeck, G., Foggi, B., Gabellini, A., Galasso, G., Gianguzzi, L., Gottschlich, G., Gubellini, L., Hofmann, N., Iamonico, D., Laface, V. L. A., Lonati, M., Lucarini, D., Lupoletti, J., Marchiano, R., Marenzi, P., Martignoni, M., Mei, G., Menini, F., Merli, M., Musarella, C. M., Orsenigo, S., Peccenini, S., Pennesi, R., Peruzzi, L., Pica, A., Pinzani, L., Piovesan, G., Pittarello, M., Podda, L., Enri, S. R., Roma-Marzio, F., Rosati, L., Spampinato, G., Stinca, A., Tonelli, S., Trenchi, M., Turcato, C., Viciani, D., Lastrucci, L., and BARTOLUCCI F., DOMINA G., ANDREATTA S., ARGENTI C., BACCHETTA G., BALLELLI S., BANFI E., BARBERIS D., BARBERIS G., BEDINI G., BOLPAGNI R., BONALI F., BOVIO M., BRIOZZO I., BRUSCO A., CALDARELLA O., CAMPUS G., CANCELLIERI L., CAROTENUTO L., CHELI E., DAGNINO D., DEL GUACCHIO E., FARRIS E., FERRETTI G., FILIBECK F., FOGGI B., GABELLINI A., GALASSO G., GIANGUZZI L., GOTTSCHLICH G., GUBELLINI L., HOFMANN N., IAMONICO D., LAFACE V.L.A., LONATI M., LUCARINI D., LUPOLETTI J., MARCHIANÒ R., MARENZI P., MARTIGNONI M., MEI G., MENINI F., MERLI M., MUSARELLA C.M., ORSENIGO S., PECCENINI S., PENNESI R., PERUZZI L., PICA A., PINZANI L., PIOVESAN G., PITTARELLO M., PODDA L., RAVETTO ENRI S., ROMA-MARZIO F., ROSATI L., SPAMPINATO G., STINCA A., TONELLI S., TRENCHI M., TURCATO C., VICIANI D., LASTRUCCI L.

Subjects
0106 biological sciences, Flora, Endemic taxa, Endemic taxa, Floristic data, Italy, Floristic data, Italy, Botany, Zoology, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, QK1-989, Settore BIO/03 - Botanica Ambientale E Applicata, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, exclusions, and status changes to the Italian administrative regions. A new combination in the genus Pilosella is proposed. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as Suppl. material 1.

Published
2021

5. Impact of invasive alien plants on native plant communities and Natura 2000 habitats: State of the art, gap analysis and perspectives in Italy

Author

Alberto Selvaggi, Mariacristina Villani, Michele Aleffi, Andrea Mainetti, Lorenzo Lazzaro, S. Ceschin, Rodolfo Gentili, V. Di Cecco, Marina Allegrezza, L. Carnevali, Annalena Cogoni, Giovanni Spampinato, Fernando Lucchese, M. Bovio, Michele Lonati, A. Acosta, L. Sottovia, Simonetta Bagella, Francesco Bracco, Silvia Paola Assini, M. Vidali, L. Poggio, Adriano Stinca, Gianfranco Pirone, Bruno Paura, M. Adorni, Piero Genovesi, Anna Rita Frattaroli, Giuseppe Brundu, Bruno Foggi, Enrico V. Perrino, Rossano Bolpagni, Angela Stanisci, Roberto Venanzoni, Marco Caccianiga, Leonardo Rosati, Marta Puglisi, Daniele Viciani, Marcella Maria Mariotti, Gianmaria Bonari, Lorenzo Lastrucci, Daniela Gigante, M. Pellizzari, Livio Poldini, Filippo Prosser, Gabriella Buffa, S. Poponessi, Claudia Angiolini, I. Prisco, Giampiero Ciaschetti, Pietro Minissale, Lazzaro, L, Bolpagni, R, Buffa, G, Gentili, R, Lonati, M, Stinca, A, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Caccianiga, M, Carnevali, L, Di Cecco, V, Ceschin, S, Ciaschetti, G, Cogoni, A, Foggi, B, Frattaroli, A, Genovesi, P, Gigante, D, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Venanzoni, R, Viciani, D, Vidali, M, Villani, M, Lastrucci, L, Lazzaro, L., Bolpagni, R., Buffa, G., Gentili, R., Lonati, M., Stinca, A., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Caccianiga, M., Carnevali, L., Di Cecco, V., Ceschin, S., Ciaschetti, G., Cogoni, A., Foggi, B., Frattaroli, A. R., Genovesi, P., Gigante, D., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, M., and Lastrucci, L.

Subjects
Competition, Ecological impact, Expert survey, Impact mechanism, Impact outcome, Natura 2000 network, Environmental Engineering, 0208 environmental biotechnology, Biodiversity, Introduced species, 02 engineering and technology, Alien, 010501 environmental sciences, Management, Monitoring, Policy and Law, 01 natural sciences, Italy, Plants, Ecosystem, Introduced Species, media_common.cataloged_instance, European union, Waste Management and Disposal, 0105 earth and related environmental sciences, media_common, BIO/03 - BOTANICA AMBIENTALE E APPLICATA, Ecology, Plant community, General Medicine, Plant, Native plant, 020801 environmental engineering, Geography, Habitat, Natura 2000, Settore BIO/03 - Botanica Ambientale e Applicata
Abstract

Invasive alien plants are a major threat to biodiversity and they contribute to the unfavourable conservation status of habitats of interest to the European Community. In order to favour implementation of European Union Regulation no. 1143/2014 on invasive alien species, the Italian Society of Vegetation Science carried out a large survey led by a task force of 49 contributors with expertise in vegetation across all the Italian administrative regions. The survey summed up the knowledge on impact mechanisms of invasive alien plants in Italy and their outcomes on plant communities and the EU habitats of Community Interest, in accordance with Directive no. 92/43/EEC. The survey covered 241 alien plant species reported as having deleterious ecological impacts. The data collected illustrate the current state of the art, highlight the main gaps in knowledge, and suggest topics to be further investigated. In particular, the survey underlined competition as being the main mechanism of ecological impact on plant communities and Natura 2000 habitats. Of the 241 species, only Ailanthus altissima was found to exert an ecological impact on plant communities and Natura 2000 habitats in all Italian regions; while a further 20 species impact up to ten out of the 20 Italian administrative regions. Our data indicate that 84 out of 132 Natura 2000 Habitats (64%) are subjected to some degree of impact by invasive alien plants. Freshwater habitats and natural and semi-natural grassland formations were impacted by the highest number of alien species, followed by coastal sand dunes and inland dunes, and forests. Although not exhaustive, this research is the first example of nationwide evaluation of the ecological impacts of invasive alien plants on plant communities and Natura 2000 Habitats.

Published
2020

6. Notulae to the Italian native vascular flora: 9

Author

Francesco Festi, D. Marchetti, Gianluigi Bacchetta, Paola Liguori, Davide Barberis, Riccardo Pennesi, Filippo Prosser, Maurizio Trenchi, Sandro Ballelli, Francesco Roma-Marzio, Nicodemo G. Passalacqua, Valeria Tomaselli, Giuseppina Chianese, Antonietta Crisanti, Adriano Stinca, Mariangela Pellegrino, Gina Pirastru, Giancarlo Tondi, Ian Briozzo, Gabriele Galasso, Fernando Lucchese, Simone Ravetto Enri, Fabrizio Bartolucci, Luigi Minuto, Davide Dagnino, Claudia Turcato, Daniela Longo, Mauro Mariotti, Chiara Toffolo, Lorenzo Pinzani, Flavio Menini, Enrico Banfi, Alessio Bertolli, Sebastiano Andreatta, Chiara Nepi, Gianniantonio Domina, Alfredo Di Filippo, Carlo Cibei, Giovanni Russo, Gianmaria Bonari, Giovanna Orrù, Lorenzo Peruzzi, Maria Loredana Pala, Simonetta Fanni, Maria Carmine Locci, M. Bovio, Günter Gottschlich, Assunta Esposito, Giacomo Calvia, Roberto Angius, Giuseppe Silletti, Rodolfo Gentili, E. Lattanzi, Luigi Forte, Maurizio Copez, Nicola M. G. Ardenghi, G. Barberis, Fabio Conti, Liliana Bernardo, Giovanni Buccomino, Michele Lonati, Anna Scoppola, Bartolucci F., Domina G., Andreatta S., Angius R., Ardenghi N.M.G., Bacchetta G., Ballelli S., Banfi E., Barberis D., Barberis G., Bernardo L., Bertolli A., Bonari G., Bovio M., Briozzo I., Buccomino G., Calvia G., Chianese G., Cibei C., Conti F., Copez M., Crisanti A., Dagnino D., Di Filippo A., Esposito A., Fanni S., Festi F., Forte L., Galasso G., Gentili R., Gottschlich G., Lattanzi E., Liguori P., Locci M.C., Longo D., Lonati M., Lucchese F., Marchetti D., Mariotti M.G., Menini F., Minuto L., Orru G., Pala M.L., Passalacqua N.G., Pellegrino M., Pennesi R., Peruzzi L., Pinzani L., Pirastru G., Prosser F., Enri S.R., Roma-Marzio F., Russo G., Scoppola A., Silletti G., Stinca A., Toffolo C., Tomaselli V., Tondi G., Trenchi M., Turcato C., Nepi C., Bartolucci, F, Domina, G, Andreatta, S, Angius, R, Ardenghi, Nmg, Bacchetta, G, Ballelli, S, Banfi, E, Barberis, D, Barberis, G, Bernardo, L, Bertolli, A, Bonari, G, Bovio, M, Briozzo, I, Buccomino, G, Calvia, G, Chianese, G, Cibei, C, Conti, F, Copez, M, Crisanti, A, Dagnino, D, Di Filippo, A, Esposito, A, Fanni, S, Festi, F, Forte, L, Galassog, Gentili, R, Gottschlich, G, Lattanzi, E, Liguori, P, Locci, Mc, Longo, D, Lonati, M, Lucchese, F, Marchetti, D, Mariotti, M, Flavio Menini, F, Luigi Minuto, L, Orrù, G, Loredana Pala, Ml, Passalacqua, Ng, Pellegrino, M, Pennesi, R, Peruzzi, L, Pinzani, L, Pirastru, G, Prosser, F, Ravetto Enri, S, Roma-Marzio, F, Russo, G, Scoppola, A, Silletti, G, Stinca, A, Toffolo, C, Tomaselli, V, Tondi, G, Trenchi, M, Turcato, C, Nepi, C, Ardenghi, N, Galasso, G, Locci, M, Menini, F, Minuto, L, Orru, G, Pala, M, Passalacqua, N, and Enri, S

Subjects
Endemic, Floristic data, Italy, Nomenclature, Endemic Floristic data Italy Nomenclature, 0106 biological sciences, BIO/03 - BOTANICA AMBIENTALE E APPLICATA, 010506 paleontology, Flora, Nomenclature, Zoology, Floristic data, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, lcsh:QK1-989, Endemic, Italy, lcsh:Botany, BIO/02 - BOTANICA SISTEMATICA, Settore BIO/03 - Botanica Ambientale E Applicata, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences
Abstract

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, exclusions, and status changes to the Italian administrative regions. Two new combinations are proposed. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as Suppl. material 1.

Published
2020

7. Verso una checklist della vegetazione alloctona in Italia

Author

S. Bagella, D. Viciani, M. Vidali, D. Gigante, R. Bolpagni, M. Villani, A. T. R. Acosta, M. Adorni, M. Aleffi, M. Allegrezza, C. Angiolini, S. Assini, G. Bonari, M. Bovio, F. Bracco, G. Brundu, G. Buffa, M. Caccianiga, L. Carnevali, S. Ceschin, G. Ciaschetti, A. Cogoni, V. Di Cecco, B. Foggi, A. R. Frattaroli, P. Genovesi, R. Gentili, L. Lazzaro, M. Lonati, F. Lucchese, A. Mainetti, M. Mariotti, P. Minissale, B. Paura, M. Pellizzari, E. V. Perrino, G. Pirone, L. Poggio, L. Poldini, S. Poponessi, I. Prisco, F. Prosser, M. Puglisi, L. Rosati, A. Selvaggi, L. Sottovia, G. Spampinato, A. Stanisci, A. Stinca, R. Venanzoni, L. Lastrucci, Bagella, S., Viciani, D., Vidali, M., Gigante, D., Bolpagni, R., Villani, M., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A. R., Genovesi, P., Gentili, R., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., and Lastrucci, L.

Published
2019

8. Contribution to the floristic knowledge of the head of the Po Valley (Piedmont, north Italy)

Author

Adriano Stinca, Giovanni Salerno, C. Gangale, A. Tilia, M. Bovio, Simonetta Fascetti, Enrico V. Perrino, Simonetta Peccenini, Fabrizio Bartolucci, Dimitar Uzunov, Leonardo Rosati, A. Soldano, E. Lattanzi, Fabio Conti, Gabriele Galasso, Enrico Banfi, Massimo Barbo, Annalaura Pistarino, Francesco Faraoni, Laura Cancellieri, Romeo Di Pietro, R. Masin, Daniela Bouvet, Vito Antonio Romano, Bouvet, D, Pistarino, A, Soldano, A, Banfi, E, Barbo, M, Bartolucci, F, Bovio, M, Cancellieri, L, Conti, F, DI PIETRO, R, Faraoni, F, Fascetti, S, Galasso, G, Gangale, C, Lattanzi, E, Peccenini, S, Perrino, Ev, Masin, Rr, Romano, Va, Rosati, L, Salerno, G, Stinca, A, Tilia, A, and Uzunov, D

Subjects
0106 biological sciences, vascular flora, new floristic records, Plant Science, Cottian Alps, regional flora, new floristic records, vascular flora, regional flora, 010603 evolutionary biology, 01 natural sciences, Archaeology, Floristics, Head (geology), lcsh:QK1-989, Geography, lcsh:Botany, Cottian Alps, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany
Abstract

In 2014, the annual field trip of the working group for Floristics, Systematics, and Evolution of the Italian Botanical Society was held in Piemonte (northern Italy), at the head of the Po Valley. This valley, at whose extremity is located the Monviso (3,841 m a.s.l.), belongs to the Cottian Alps about which very little is known from a floristic point of view. An inventory of the taxa of vascular plants collected during the field trip is reported here. The research led to the identification of 3,546 exsiccata, kept in nine public and nine private collections. A total of 669 taxa belonging to 79 plant families were recorded. Six taxa resulted endemic to Italy and three exclusive to Piemonte, while only nine alien species were detected; six taxa are new and five confirmed for the regional flora.

Published
2018

9. Red Listing plants under full national responsibility: Extinction risk and threats in the vascular flora endemic to Italy

Author

Eugenio Duprè, Mariacristina Villani, Gianniantonio Domina, Domenico Gargano, Gianluigi Bacchetta, M. Bovio, Enrico V. Perrino, Sara Magrini, Miris Castello, Chiara Montagnani, Giuseppe Fenu, T. Wilhalm, Graziano Rossi, Mauro Iberite, Lorenzo Peruzzi, Alberto Selvaggi, Angelino Carta, Filippo Prosser, Carlo Blasi, Donatella Cogoni, Adriano Stinca, Annalisa Santangelo, Robert P. Wagensommer, C. Lasen, Bruno Foggi, Thomas Abeli, Simone Orsenigo, Daniela Gigante, Fabrizio Bartolucci, N. Tartaglini, Salvatore Brullo, Fabio Conti, Cristian Brullo, Matilde Gennai, A. Alessandrini, Ilda Vagge, Orsenigo S., Montagnani C., Fenu G., Gargano D., Peruzzi L., Abeli T., Alessandrini A., Bacchetta G., Bartolucci F., Bovio M., Brullo C., Brullo S., Carta A., Castello M., Cogoni D., Conti F., Domina G., Foggi B., Gennai M., Gigante D., Iberite M., Lasen C., Magrini S., Perrino E.V., Prosser F., Santangelo A., Selvaggi A., Stinca A., Vagge I., Villani M., Wagensommer R.P., Wilhalm T., Tartaglini N., Dupre E., Blasi C., Rossi G., Orsenigo, Simone, Montagnani, Chiara, Fenu, Giuseppe, Gargano, Domenico, Peruzzi, Lorenzo, Abeli, Thoma, Alessandrini, Alessandro, Bacchetta, Gianluigi, Bartolucci, Fabrizio, Bovio, Maurizio, Brullo, Cristian, Brullo, Salvatore, Carta, Angelino, Castello, Miri, Cogoni, Donatella, Conti, Fabio, Domina, Gianniantonio, Foggi, Bruno, Gennai, Matilde, Gigante, Daniela, Iberite, Mauro, Lasen, Cesare, Magrini, Sara, Perrino, Enrico V., Prosser, Filippo, Santangelo, Annalisa, Selvaggi, Alberto, Stinca, Adriano, Vagge, Ilda, Villani, Mariacristina, Wagensommer, Robert P., Wilhalm, Thoma, Tartaglini, Nicoletta, Duprè, Eugenio, Blasi, Carlo, Rossi, Graziano, Orsenigo, S, Montagnani, C, Fenu, G, Gargano, D, Peruzzi, L, Abeli, T, Alessandrini, A, Bacchetta, G, Bartolucci, F, Bovio, M, Brullo, C, Brullo, S, Carta, A, Castello, M, Cogoni, D, Conti, F, Domina, G, Foggi, B, Gennai, M, Gigante, D, Iberite, M, Lasen, C, Magrini, S, Perrino, E, Prosser, F, Santangelo, A, Selvaggi, A, Stinca, A, Vagge, I, Villani, M, Wagensommer, R, Wilhalm, T, Tartaglini, N, Duprè, E, Blasi, C, and Rossi, G

Subjects
0106 biological sciences, Behavior and Systematic, Biodiversity conservation, Endemic rich areas, Endemic taxa, IUCN Red Lists, Mediterranean Basin, Species richness, Taxonomic knowledge, Flora, Species richne, Evolution, Biodiversity conservation, Endemic rich areas, Endemic taxa, IUCN Red Lists, Mediterranean Basin, Species richness, Taxonomic knowledge, 010603 evolutionary biology, 01 natural sciences, Plant Ecology, Nature and Landscape Conservation, IUCN Red List, Ecology, Evolution, Behavior and Systematics, Data deficient, Extinction, Endemic rich area, Ecology, 010604 marine biology & hydrobiology, Ecology, Evolution, Behavior and Systematic, Biodiversity hotspot, Habitat destruction, Geography, Threatened species, Protected area
Abstract

Taxa endemic to a country are key elements for setting national conservation priorities and for driving conservation strategies, since their persistence is entirely dependent on national policy. We applied the IUCN Red List categories to all Italian endemic vascular plants (1340 taxa) to assess their current risk of extinction and to highlight their major threats. Our results revealed that six taxa are already extinct and that 22.4% (300 taxa) are threatened with extinction, while 18.4% (247; especially belonging to apomictic groups) have been categorized as Data Deficient. Italian endemic vascular plants are primarily threatened by natural habitat modification due to agriculture, residential and tourism development. Taxa occurring in coastal areas and lowlands, where anthropogenic impacts and habitat destruction are concentrated, display the greatest population decline and extinction. The national network of protected areas could be considered effective in protecting endemic-rich areas (ERAs) and endemic taxa, but ineffective in protecting narrow endemic-rich areas (NERAs), accordingly changes to the existing network may increase the effectiveness of protection. For the first time in the Mediterranean Basin biodiversity hotspot, we present a comprehensive extinction assessment for endemic plants under the full responsibility of a single country. This would provide an important step towards the prioritization and conservation of threatened endemic flora at Italian, European, and Mediterranean level. A successful conservation strategy of the Italian endemic vascular flora should implement the protected area system, solve some taxonomical criticism in poorly known genera, and should rely on monitoring threatened species, and on developing species-specific action plans.

Published
2018

10. An updated checklist of the vascular flora alien to Italy

Author

G. Galasso, F. Conti, L. Peruzzi, N. M. G. Ardenghi, E. Banfi, L. Celesti-Grapow, A. Albano, A. Alessandrini, G. Bacchetta, S. Ballelli, M. Bandini Mazzanti, G. Barberis, L. Bernardo, C. Blasi, D. Bouvet, M. Bovio, L. Cecchi, E. Del Guacchio, G. Domina, S. Fascetti, L. Gallo, L. Gubellini, A. Guiggi, D. Iamonico, M. Iberite, P. Jiménez-Mejías, E. Lattanzi, D. Marchetti, E. Martinetto, R. R. Masin, P. Medagli, N. G. Passalacqua, S. Peccenini, R. Pennesi, B. Pierini, L. Podda, L. Poldini, F. Prosser, F. M. Raimondo, F. Roma-Marzio, L. Rosati, A. Santangelo, A. Scoppola, S. Scortegagna, A. Selvaggi, F. Selvi, A. Soldano, A. Stinca, R. P. Wagensommer, T. Wilhalm, F. Bartolucci, Galasso, G, Conti, F, Peruzzi, L, Ardenghi, Nmg, Banfi, E, Celesti-Grapow, L, Albano, A, Alessandrini, A, Bacchetta, G, Ballelli, S, Bandini Mazzanti, M, Barberis, G, Bernardo, L, Blasi, C, Bouvet, D, Bovio, M, Cecchi, L, Del Guacchio, E, Domina, G, Fascetti, S, Gallo, L, Gubellini, L, Guiggi, A, Iamonico, D, Iberite, M, Jiménez-Mejías, P, Lattanzi, E, Marchetti, D, Martinetto, E, Masin, Rr, Medagli, P, Passalacqua, Ng, Peccenini, S, Pennesi, R, Pierini, B, Podda, L, Poldini, L, Prosser, F, Raimondo, Fm, Roma-Marzio, F, Rosati, L, Santangelo, A, Scoppola, A, Scortegagna, A, Selvaggi, A, Selvi, F, Soldano, A, Stinca, A, Wagensommer, Rp, Wilhalm, T & Bartolucci F, Galasso, G., Conti, F., Peruzzi, L., Ardenghi, N. M. G., Banfi, E., Celesti-Grapow, L., Albano, A., Alessandrini, A., Bacchetta, G., Ballelli, S., Bandini Mazzanti, M., Barberis, G., Bernardo, L., Blasi, C., Bouvet, D., Bovio, M., Cecchi, L., Del Guacchio, E., Domina, G., Fascetti, S., Gallo, L., Gubellini, L., Guiggi, A., Iamonico, D., Iberite, M., Jiménez-Mejías, P., Lattanzi, E., Marchetti, D., Martinetto, E., Masin, R. R., Medagli, P., Passalacqua, N. G., Peccenini, S., Pennesi, R., Pierini, B., Podda, L., Poldini, L., Prosser, F., Raimondo, F. M., Roma-Marzio, F., Rosati, L., Santangelo, A., Scoppola, A., Scortegagna, S., Selvaggi, A., Selvi, F., Soldano, A., Stinca, A., Wagensommer, R. P., Wilhalm, T., Bartolucci, F., Jimenez-Mejias, P., Ardenghi, N.M.G., Masin, R.R., Passalacqua, N.G., Raimondo, F.M., and Wagensommer, R.P.

Subjects
0106 biological sciences, Floristic diversity, Mediterranean flora, non-native flora, plant invasion, taxonomy, Ecology, Evolution, Behavior and Systematics, Plant Science, Ecology, Evolution, Settore BIO/02 - Botanica Sistematica, 010603 evolutionary biology, 01 natural sciences, Ecology, Evolution, Behavior and Systematic, nonnative flora, Behavior and Systematics, Settore BIO/03 - Botanica Ambientale E Applicata, floristic diversity, mediterranean flora, 010606 plant biology & botany, Floristic diversity, Mediterranean flora, nonnative flora, plant invasion, taxonomy
Abstract

An updated inventory of the vascular flora alien to Italy, providing details on the occurrence at regional level, is presented. The checklist includes 1597 species, subspecies, and hybrids, distributed in 725 genera and 152 families; 2 taxa are lycophytes, 11 ferns and fern allies, 33 gymnosperms, and 1551 angiosperms. 157 taxa are archaeophytes and 1440 neophytes. The alien taxa currently established in Italy are 791 (570 naturalized and 221 invasive), while 705 taxa are casual aliens, 4 are not assessed, 7 are of unknown regional distribution, 47 have not been confirmed in recent times, 3 are considered extinct or possibly extinct in the country, and 40 are doubtfully occurring in Italy. This checklist allows to establish an up-to-date number (9792) of taxa constituting the whole (native and alien) Italian flora.

Published
2018

11. An updated checklist of the vascular flora native to Italy

Author

Bruno Foggi, Pietro Medagli, S. Scortegagna, A. Alessandrini, B. Pierini, Alberto Selvaggi, Edoardo Martinetto, Simonetta Fascetti, Francesco Roma-Marzio, Lorenzo Cecchi, Gianluigi Bacchetta, Liliana Bernardo, Filippo Prosser, Robert P. Wagensommer, D. Marchetti, Sandro Ballelli, Duilio Iamonico, G. Barberis, T. Wilhalm, Riccardo Pennesi, Antonella Albano, Lorenzo Peruzzi, A. Soldano, Fabrizio Bartolucci, Giuseppe Fenu, Adriano Stinca, L. Gubellini, Annalisa Santangelo, R. Masin, Francesco Festi, Mauro Iberite, Anna Scoppola, Livio Poldini, R. Di Pietro, Nicola M. G. Ardenghi, Simonetta Peccenini, Enrico Banfi, Günter Gottschlich, Nicodemo G. Passalacqua, Lorenzo Gallo, Federico Selvi, Daniela Bouvet, E. Lattanzi, Pedro Jiménez-Mejías, Giovanni Astuti, Francesco Maria Raimondo, Leonardo Rosati, Gabriele Galasso, Gianniantonio Domina, M. Bovio, Fabio Conti, Bartolucci, F., Peruzzi, L., Galasso, G., Albano, A., Alessandrini, A., Ardenghi, N. M. G., Astuti, G., Bacchetta, G., Ballelli, S., Banfi, E., Barberis, G., Bernardo, L., Bouvet, D., Bovio, M., Cecchi, L., Di Pietro, R., Domina, G., Fascetti, S., Fenu, G., Festi, F., Foggi, B., Gallo, L., Gottschlich, G., Gubellini, L., Iamonico, D., Iberite, M., Jimenez-Mejias, P., Lattanzi, E., Marchetti, D., Martinetto, E., Masin, R. R., Medagli, P., Passalacqua, N. G., Peccenini, S., Pennesi, R., Pierini, B., Poldini, L., Prosser, F., Raimondo, F. M., Roma-Marzio, F., Rosati, L., Santangelo, A., Scoppola, A., Scortegagna, S., Selvaggi, A., Selvi, F., Soldano, A., Stinca, A., Wagensommer, R. P., Wilhalm, T., Conti, F., Jiménez-Mejías, P., Bartolucci, F, Peruzzi, L, Galasso, G, Albano, A, Alessandrini, A, Ardenghi, Nmg, Astuti, G, Bacchetta, G, Ballelli, S, Banfi, E, Barberis, G, Bernardo, L, Bouvet, D, Bovio, M, Cecchi, L, Di Pietro, R, Domina, G, Fascetti, S, Fenu, G, Festi, F, Foggi, B, Gallo, L, Gottschlich, G, Gubellini, L, Iamonico, D, Iberite, M, Jiménez-Mejías, P, Lattanzi, E, Marchetti, D, Martinetto, E, Masin, Rr, Medagli, P, Passalacqua, Ng, Peccenini, S, Pennesi, R, Pierini, B, Poldini, L, Prosser, F, Raimondo, Fm, Roma-Marzio, F, Rosati, L, Santangelo, A, Scoppola, A, Scortegagna, A, Selvaggi, A, Selvi, F, Soldano, A, Stinca, A, Wagensommer, Rp, Wilhalm, T & Conti F, Ardenghi, N.M.G., Masin, R.R., Passalacqua, N.G., Raimondo, F.M., and Wagensommer, R.P.

Subjects
0106 biological sciences, Endemism, floristic diversity, Italy, Mediterranean flora, taxonomy, Ecology, Evolution, Behavior and Systematics, Plant Science, endemism, mediterranean flora, ecology, evolution, behavior and systematics, plant science, Introduced species, Alien, Subspecies, 010603 evolutionary biology, 01 natural sciences, Endemism, floristic diversity, Italy, Mediterranean flora, taxonomy, biology, Ecology, Settore BIO/02 - Botanica Sistematica, Endemism floristic diversity, biology.organism_classification, Ecology, Evolution, Behavior and Systematic, Checklist, Taxon, Geography, Settore BIO/03 - Botanica Ambientale E Applicata, Taxonomy (biology), Fern, 010606 plant biology & botany
Abstract

An updated inventory of the vascular flora alien to Italy, providing details on the occurrence at regional level, is presented. The checklist includes 1597 species, subspecies, and hybrids, distributed in 725 genera and 152 families; 2 taxa are lycophytes, 11 ferns and fern allies, 33 gymnosperms, and 1551 angiosperms. 157 taxa are archaeophytes and 1440 neophytes. The alien taxa currently established in Italy are 791 (570 naturalized and 221 invasive), while 705 taxa are casual aliens, 4 are not assessed, 7 are of unknown regional distribution, 47 have not been confirmed in recent times, 3 are considered extinct or possibly extinct in the country, and 40 are doubtfully occurring in Italy. This checklist allows to establish an up-to-date number (9792) of taxa constituting the whole (native and alien) Italian flora.

Published
2018

12. At the intersection of cultural and natural heritage: Distribution and conservation of the type localities of Italian endemic vascular plants

Author

A. Croce, G. Barberis, Liliana Bernardo, Luisa Carta, Duilio Iamonico, Gabriella Vacca, Stefano Marsili, A Brunu, Adriano Stinca, Annalisa Santangelo, Fabrizio Bartolucci, Cristina Salmeri, Gianluca Iiriti, Antonella Albano, Elisabetta Scassellati, Giuseppe Brundu, Daniela Longo, Mauro Mariotti, Riccardo Pennesi, Robert P. Wagensommer, Mariacristina Villani, Lorenzo Peruzzi, Ignazio Camarda, A. Alessandrini, Pietro Medagli, Simonetta Peccenini, Salvatore Brullo, Fabio Conti, Enrico Banfi, Francesco Maria Raimondo, Gabriele Galasso, Gianniantonio Domina, M. Bovio, Mauro Iberite, Annalaura Pistarino, Nicodemo G. Passalacqua, Federico Selvi, Brundu, GIUSEPPE ANTONIO DOMENICO, Peruzzi, Lorenzo, Domina, Gianniantonio, Bartolucci, Fabrizio, Galasso, Gabriele, Peccenini, Simonetta, Raimondo, Francesco Maria, Albano, Antonella, Alessandrini, Alessandro, Banfi, Enrico, Barberis, Giuseppina, Bernardo, Liliana, Bovio, Maurizio, Brullo, Salvatore, Brunu, Antonello, Camarda, Ignazio, Carta, Luisa, Conti, Fabio, Croce, Antonio, Iamonico, Duilio, Iberite, Mauro, Iiriti, Gianluca, Longo, Daniela, Marsili, Stefano, Medagli, Pietro, Mariotti, Mauro Giorgio, Pennesi, Riccardo, Pistarino, Annalaura, Salmeri, Cristina, Santangelo, Annalisa, Scassellati, Elisabetta, Selvi, Federico, Stinca, Adriano, Vacca, Gabriella, Villani, Mariacristina, Wagensommer, Robert Philipp, Passalacqua, Nicodemo Giuseppe, Brundu, G., Peruzzi, L., Domina, G., Bartolucci, F., Galasso, G., Peccenini, S., Raimondo, F., Albano, A., Alessandrini, A., Banfi, E., Barberis, G., Bernardo, L., Bovio, M., Brullo, S., Brunu, A., Camarda, I., Carta, L., Conti, F., Croce, A., Iamonico, D., Iberite, M., Iiriti, G., Longo, D., Marsili, S., Medagli, P., Mariotti, M., Pennesi, R., Pistarino, A., Salmeri, C., Santangelo, A., Scassellati, E., Selvi, F., Stinca, A., Vacca, G., Villani, M., Wagensommer, R., Passalacqua, N., Brundu, Giuseppe, Raimondo, F. M., Mariotti, M. G., Wagensommer, R. P., and Passalacqua, N. G.

Subjects
0106 biological sciences, Mediterranean climate, Behavior and Systematic, 010504 meteorology & atmospheric sciences, Evolution, Distribution (economics), Conservation, 010603 evolutionary biology, 01 natural sciences, Endemic, Type (biology), Endemics, Italian flora, Loci classici, Spatial analysis, Natural heritage, Resource management, Endemism, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, Italian flora, Conservation, Endemics, Spatial analysis, Loci classici, Nature and Landscape Conservation, Ecology, business.industry, Settore BIO/02 - Botanica Sistematica, Ecology, Evolution, Behavior and Systematic, Geography, Important Plant Areas, Spatial analysi, Settore BIO/03 - Botanica Ambientale E Applicata, Mainland, business
Abstract

We conducted a GIS spatial analysis with the aim of providing the first quantitative large-scale overview of the distribution patterns of 1536 type localities ( loci classici ) of 1216 Italian endemic vascular plants and their relationship with a set of descriptive variables. Whereas some variables were used to model the presence-absence distribution patterns of the type localities for the whole set of endemics as well as for the subset of narrow endemics, others (e.g., presence inside or outside protected areas and Italian Important Plant Areas) were considered with the purpose of assessing potential assets or risks for conservation. The largest number of type localities was found within the Mediterranean biogeographic region (1134), followed by the Alpine region (306) and Continental region (96). A total of 670 locations are located on islands, whereas 866 are located on the Italian mainland (139 and 124 in the case of narrow endemics, respectively). A large number of type localities are located in mountainous areas and along the coastline, which can be seen as a potential risk for conservation. On the contrary, we detected a positive correlation with the distance from roads, which might be considered to be an asset. Importantly, 1030 type localities fall inside protected areas, whereas 506 localities fall outside protected areas, with 259 of these unprotected localities on islands. We propose considering the results of the analysis of the distribution of type localities of Italian endemics to be a strategic tool for conservation planning and resource management. Application of plant micro-reserves and integration of diverse legislation tools are suggested to strengthen efforts and increase conservation success.

Published
2017

13. Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma

Author

Peter A. Drew, Ian M. Bovio, Charles J. Rosser, Samer Z. Al-Quran, Robert W. Allan, and Chester B. Algood

Subjects
medicine.medical_specialty, Pathology, Histology, Muscularis mucosae, Urinary bladder, Bladder cancer, business.industry, medicine.medical_treatment, Anatomical pathology, General Medicine, medicine.disease, Pathology and Forensic Medicine, Cystectomy, medicine.anatomical_structure, Carcinoma, medicine, Immunohistochemistry, Smoothelin, business
Abstract

Bovio I M, Al-Quran S Z, Rosser C J, Algood C B, Drew P A & Allan R W (2010) Histopathology 56, 951–956 Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma Aims: To prospectively evaluate the utility of smoothelin immunohistochemical expression for the evaluation of muscularis propria (MP) in diagnostic transurethral resection of bladder tumour (TURBT) specimens and cystectomies. Methods and results: Smoothelin immunohistochemistry was performed on a total of 26 TURBT and cystectomy specimens. All but two cases (24/26) demonstrated strong (3+) or moderate (2+) immunoreactivity of the MP with smoothelin. Muscularis mucosae (MM) never displayed strong (3+) reactivity, and in only one case did the MM have moderate (2+) reactivity; in this case the MP had strong (3+) reactivity. MM intensity mirrored the intensity of reactivity of blood vessels in all cases (26/26). Using moderate or strong immunoreactivity as a cut-off, smoothelin had a sensitivity of 92% for detecting MP and a specificity of 97% for distinguishing between MP and MM. In all unequivocal MP-invasive and lamina proporia-invasive cases by haematoxylin and eosin (H&E), smoothelin immunohistochemistry confirmed the original light microscopic diagnosis. In four cases in which there was equivocal MP involvement by H&E, smoothelin helped establish MP invasion. Conclusions: Smoothelin immunohistochemistry has diagnostic utility in the evaluation of MP invasion in urothelial carcinoma. Smoothelin could be used as an adjunct to traditional H&E-stained light microscopy and may help reduce the number of equivocal diagnoses.

Published
2010

14. Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

Author

Matthew J. Delano, Yutaro Kumagai, Jason S. Weinstein, Samer Z. Al-Quran, Shizuo Akira, Kindra M. Kelly-Scumpia, Ian M. Bovio, Alex G. Cuenca, Lyle L. Moldawer, and Philip O. Scumpia

Subjects
Lipopolysaccharides, medicine.medical_treatment, Immunology, Bone Marrow Cells, Mice, Inbred Strains, Biology, Article, Mice, Bone Marrow, In vivo, medicine, Animals, Immunology and Allergy, Progenitor cell, Cecum, Ligation, Cells, Cultured, Cell Proliferation, Mice, Knockout, Mice, Inbred C3H, Interleukin-6, Stem Cells, Receptors, Interleukin-1, Bacterial Infections, Staphylococcal Infections, Flow Cytometry, Hematopoietic Stem Cells, Cell biology, Mice, Inbred C57BL, Toll-Like Receptor 4, Adaptor Proteins, Vesicular Transport, Haematopoiesis, medicine.anatomical_structure, Cytokine, TRIF, Myeloid Differentiation Factor 88, TLR4, Bone marrow, Stem cell, Signal Transduction
Abstract

Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be activated by type I IFNs, TLR agonists, viruses, and bacteria to increase hematopoiesis. In this study, we report that endotoxin treatment in vivo induces TLR4, MyD88, and Toll/IL-1 resistance domain-containing adaptor-inducing IFN-β (TRIF)-dependent expansion of BM HSPCs. Bacterial infection by Staphylococcus aureus or cecal ligation and puncture also induces HSPC expansion, but MyD88, TRIF, type I IFN, cytokine, PG, or oxidative stress pathways are not required for their expansion. S. aureus-induced HSPC expansion in MyD88−/−TRIF−/− mice is also normal, but is associated with BM remodeling as granulocyte stores are released peripherally. Importantly, reduction in BM cellularity alone can reproduce HSPC expansion. These data show in vivo HSPC responses to bacterial infection are complex and not absolutely dependent upon key inflammatory signaling pathways.

Published
2010

15. Inventory of the non‐native flora of Italy

Author

T. Wilhalm, Liliana Bernardo, Giuseppe Brundu, Lucia Viegi, Pier Virgilio Arrigoni, A. Alessandrini, F. Pretto, Laura Celesti-Grapow, S. Marchiori, Simonetta Fascetti, Carlo Blasi, L. Gubellini, Mariacristina Villani, Simonetta Peccenini, M. R. Cagiotti, Fabio Conti, V. La Valva, Fernando Lucchese, Pietro Mazzola, Livio Poldini, Emanuela Carli, Enrico Banfi, Filippo Prosser, Ignazio Camarda, Consolata Siniscalco, M. Bovio, Gabriele Galasso, Celesti Grapow, L, Alessandrini, A, Arrigoni, Pv, Banfi, E, Bernardo, L, Bovio, M, Brundu, G, Cagiotti, Mr, Camarda, I, Carli, E, Conti, F, Fascetti, S, Galasso, G, Gubellini, L, La Valva, V, Lucchese, Fernando, Marchiori, S, Mazzola, P, Peccenini, S, Poldini, L, Pretto, F, Prosser, F, Siniscalco, C, Villani, Mc, Viegi, L, Wilhalm, T, Blasi, C., Arrigoni, PV, Cagiotti, MR, Lucchese, F, Poldini, S, Villani, MC, and Blasi, C

Subjects
Vascular plant, Flora, species inventories, plant invasions, alien flora, residence time, "italy", italy, "species inventories", "residence time", "alien flora", "plant invasions", Introduced species, Plant invasions, Plant Science, Subspecies, Invasive species, Floristics, Alien flora, Italy, Residence time, Species inventories, Ecology, Evolution, Behavior and Systematics, plant invasion, biology, Ecology, Aliena Flora, Italy, Xenophytes, biology.organism_classification, Herbarium, Taxon
Abstract

In this paper we present a comprehensive inventory of the non‐native vascular flora of Italy, which was produced within the project “A survey of the Italian non‐native flora”, funded by the Italian Ministry for the Environment. Previously published floristic accounts were the main source of information. Historical records were critically revised and integrated with recent literature, data from herbaria and some unpublished information, so as to obtain a complete, up‐to‐date catalogue of the non‐native vascular plant species that occur spontaneously in Italy. The inventory lists 1023 non‐native species and subspecies, which account for 13.4% of all the Italian flora. The Italian non‐native flora was divided, according to its residence time, into 103 archaeophytes and 920 neophytes. According to its current invasion status, it was classified into 437 casual (42.7% of all non‐native) and 524 established taxa, the latter being divided into 361 naturalized non‐invasive (35.3%) and 163 invasive taxa (15.9%). The inventory includes a group of 62 species (6.1%) that lack recent records (i.e. since 1950). By combining local expertise into a unified, nationwide scheme using a standardized method and terminology, the inventory provides the essential scientific basis for the development of plant invasion research and management in the country.

Published
2009

16. XpII.2 Translocation Renal Carcinoma With Placental Metastasis: A Case Report

Author

Ian M. Bovio, Bahram R. Oliai, Troy Hampton, Robert W. Allan, and Demaretta S. Rush

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, business.industry, Cell, Chromosomal translocation, TFE3, medicine.disease, eye diseases, Pathology and Forensic Medicine, Metastasis, Surgery, medicine.anatomical_structure, Renal cell carcinoma, Placenta, Carcinoma, Cancer research, Medicine, Anatomy, business, Placenta Diseases
Abstract

Renal cell carcinomas with sporadic Xp11.2 translocations are uncommon malignancies in children and young adults associated with several different reciprocal translocations involving the TFE3 gene located on chromosome Xp11.2. Placental metastases are extremely rare, with only a handful of cases reported. This study reports the case of a 20-year-old woman with an Xp11.2 translocation renal carcinoma that metastasized to the placenta. This is the first reported case of a renal cell carcinoma metastatic to the placenta and highlights the aggressive behavior of Xp11 translocation renal cell carcinomas.

Published
2009

17. Are Red Lists really useful for plant conservation? The New Red List of the Italian Flora in the perspective of national conservation policies

Author

Patrizia Campisi, Liliana Bernardo, L. Miserere, Sara Magrini, Michele Aleffi, Simonetta Peccenini, Lorenzo Peruzzi, Mauro Iberite, Filippo Prosser, Elena Zappa, Sonia Ravera, L. Poggio, Miris Castello, Giuseppe Venturella, T. Wilhalm, Carlo Blasi, Simonetta Bagella, Domenico Gargano, Bruno Foggi, C. Montagnani, Giuseppe Fenu, Annalisa Santangelo, Gianniantonio Domina, Thomas Abeli, M. Bovio, Matilde Gennai, Gianluigi Bacchetta, Giuseppe Fabrini, Francesco Maria Raimondo, Annalena Cogoni, Simone Orsenigo, Maria Cristina Villani, Marta Puglisi, N. Tartaglini, Fabio Conti, Fernando Lucchese, Daniela Gigante, S. Strumia, Alberto Selvaggi, Donatella Cogoni, Enrico V. Perrino, Mirca Zotti, A. Alessandrini, Gianni Bedini, Nicola M. G. Ardenghi, Graziano Rossi, Rodolfo Gentili, Robert P. Wagensommer, Fabrizio Bartolucci, Anna Maria Persiani, Emmanuele Farris, Lucchese, Fernando, Graziano, Rossi, Chiara, Montagnani, Thomas, Abeli, Domenico, Gargano, Lorenzo, Peruzzi, Rossi, G, Montagnani, C, Abeli, T, Gargano, D, Peruzzi, L, Fenu, G, Magrini, S, Gennai, M, Foggi, B, Wagensommer, Rp, Ravera, S, Cogoni, A, Aleffi, M, Alessandrini, A, Bacchetta, G, Bagella, S, Bartolucci, F, Bedini, G, Bernardo, L, Bovio, M, Castello, M, Conti, F, Domina, G, Farrise, Gentili, R, Gigante, D, Peccenini, S, Persiani, Am, Poggio, L, Prosser, F, Santangelo, A, Selvaggi, A, Villani, Mc, Wilhalm, T, Zappa, E, Zotti, M, Tartaglini, N, Ardenghi, Mg, Blasi, C, Raimondo, Fm, Venturella, G, Cogoni, D, Puglisi, M, Campisi, P, Miserere, L, Perrino, Ev, Strumia, S, Iberite, M, Fabrini, G, Orsenigo, S., G., Rossi, C., Montagnani, T., Abeli, D., Gargano, L., Peruzzi, G., Fenu, S., Magrini, M., Gennai, B., Foggi, R. P., Wagensommer, S., Ravera, A., Cogoni, M., Aleffi, A., Alessandrini, G., Bacchetta, S., Bagella, F., Bartolucci, G., Bedini, L., Bernardo, M., Bovio, M., Castello, F., Conti, G., Domina, E., Farri, R., Gentili, D., Gigante, S., Peccenini, A. M., Persiani, L., Poggio, F., Prosser, Santangelo, Annalisa, A., Selvaggi, M. C., Villani, T., Wilhalm, E., Zappa, M., Zotti, N., Tartaglini, N. M. G., Ardenghi, C., Blasi, F. M., Raimondo, G., Venturella, D., Cogoni, M., Puglisi, P., Campisi, L., Miserere, E. V., Perrino, S., Strumia, M., Iberite, F., Lucchese, G., Fabrini, S., Orsenigo, T., Abelia, A., Santangelo, N., Tartaglinia, F. M., Raimondoa, M., Puglisia, P., Campisia, L., Misererea, Strumia, Sandro, Wagensommer, RP, Farris, E, Persiani, AM, Villani, MC, Ardenghi, NMG, Raimondo, FM, Perrino, EV, Lucchese, F, Fabrinit G, Orsenigo, S, Castello, Miri, and G., Fabrinit

Subjects
policy species, Flora, Endemic species, GIS database, IUCN protocol, Italy, policy species, gis database, iucn protocol, endemic species, italy, GIS database, Regional Red List, Plant Science, Biology, red list, Italian flora, Red List Index, IUCN protocollo, Environmental protection, IUCN Red List, Endemic species, IUCN protocol, Italy, Endemism, specie endemiche, Ecology, Evolution, Behavior and Systematics, Extinction, Agroforestry, Settore BIO/02 - Botanica Sistematica, endemic species, GIS database IUCN protocol, Itlay, policy specie, policy specie, Endemic specie, Italia, Taxon, GIS banca dati, Threatened species, Settore BIO/03 - Botanica Ambientale E Applicata, endemismi, GIS banca dati, IUCN protocollo, Italia, policy specie
Abstract

La nuova Lista Rossa della flora Italiana comprende tutte le "policy" specie italiane e altre specie di nota conservazione e comprende 400 taxa di cui il 65% sono minacciate di estinzione. La Lista Rossa si basa su un enorme data-set georeferenziato utile per gli scopi di conservazione. - The New Red List of the Italian Flora includes all the Italian policy species and other species of known conservation concerns for a total of 400 taxa, 65% of which are threatened with extinction. The Red List is based on a huge georeferenced data-set useful for conservation purposes.

Published
2013

21. The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas

Author

Robert W. Allan and Ian M. Bovio

Subjects
Adult, Male, Pathology, medicine.medical_specialty, CD30, Adolescent, CD33, Sialic Acid Binding Ig-like Lectin 3, Antigens, Differentiation, Myelomonocytic, Biology, CD13 Antigens, Immunophenotyping, Antigens, CD, hemic and lymphatic diseases, medicine, Biomarkers, Tumor, Anaplastic lymphoma kinase, Humans, Anaplastic Lymphoma Kinase, Child, Anaplastic large-cell lymphoma, Aged, Retrospective Studies, Aged, 80 and over, Large-cell lymphoma, Infant, Receptor Protein-Tyrosine Kinases, General Medicine, Middle Aged, Protein-Tyrosine Kinases, medicine.disease, Flow Cytometry, Molecular biology, Immunohistochemistry, Lymphoma, Child, Preschool, Lymphoma, Large-Cell, Anaplastic, Female, CD5
Abstract

We retrospectively studied the immunophenotype by flow cytometry of 20 anaplastic large cell lymphomas (ALCLs) (9 anaplastic lymphoma kinase [ALK]+ and 11 ALK-) with a particular emphasis on the aberrant expression of the myeloid associated antigens CD13 and/or CD33. All ALCLs expressed CD45, HLA-DR, and CD30. Most (8/9) ALK+ ALCLs expressed at least 1 surface T-cell antigen (CD4, 6/9 [67%]; CD7, 6/9 [67%]; CD2, 5/9 [56%]; CD5, 2/9 [22%]; CD8, 2/9 [22%]; CD3, 1/9 [11%]). All ALK-ALCLs expressed at least 1 surface T-cell antigen (CD3, 7/11 [64%]; CD4, 6/11 [55%]; CD2, 6/11 [55%]; CD7, 2/11 [18%]; CD5, 1/11 [9%]; CD8, 1/11 [9%]). CD13 and/or CD33 were expressed in all (9/9) ALK+ ALCLs compared with 1 of 11 ALK-ALCLs (9%) (P < .0001). Surface CD3 was more likely expressed in ALK-ALCLs (7/11) compared with ALK+ ALCLs (1/9) (P .03). The myeloid-associated antigens CD13 and/or CD33 are sensitive but not entirely specific markers of ALK+ ALCLs and should not be misinterpreted as indicating myeloid sarcoma.

Published
2008

22. La gestion du sol par rapport au système de conduite dans un vignoble en forte pente

Author

G. GAY, M. BOVIO, J. L. MINATI, A. MORANDO, V. NOVELLO, and R. AMBROSOLI

Subjects
soil microflora, herbicide, grass cover, food and beverages, grape maturity, grapevine
Abstract

In the North-West Italy, close spaced and low trunk vines are vertically trellised and Guyot pruned. In these conditions the permanent grass cover may compete with grapevine leaves and clusters for air and light. In a ‘White Muscat’ vineyard, grafted on ‘420A’, the following soil management techniques were compared: a) permanent grass cover controlled by mowing; b) permanent grass cover controlled by foliar herbicides; c) no tillage using residual + foliar herbicides. The maximum soil cover was found on the grass cutting treatment. A good but reduced cover was obtained by the foliar herbicide used alone, stimulating the vine vigor, and giving more yields with higher total soluble solids concentration. The soil nitrifying microflora was less reduced by glufosinate-ammonium than by glyphosate. The grass cover was minimum using residual herbicides; as a consequence the erosion risk was enhanced, the soil total N and organic matter were reduced, yield and gray mold damages were increased.

Published
2004

23. Schede per una Lista Rossa della Flora vascolare e crittogamica Italiana: Artemisia genipi Weber ex Stechm

Author

Orsenigo, S., Selvaggi, A., Bovio, M., Poggio, L., Prosser, F., Wilhalm, T., Parolo, G., Lasen, C., Castello, Miris, Rossi, G., S., Orsenigo, A., Selvaggi, M., Bovio, L., Poggio, F., Prosser, T., Wilhalm, G., Parolo, C., Lasen, Castello, Miri, and G., Rossi

Subjects
Flora, Lista Rossa IUCN Italiana, Italia, Artemisia genipi
Abstract

Valutazione dello stato di conservazione di Artemisia genipi per la Lista Rossa della Flora vascolare e crittogamica Italiana

Published
2013

24. Sublingual sufentanil tablet system (SSTS) versus a single shot peri-nervous injection of ropivacaine for the management of postoperative pain after total knee arthroplasty: a single-center randomized trial.

Author

Monteleone G, Tasso F, De Angelis A, Martorelli F, Simili V, Bovio M, Biamino C, Anzillotti G, Di Matteo B, Marcacci M, and Scardino M

Subjects
Humans, Male, Female, Aged, Middle Aged, Administration, Sublingual, Pain Measurement, Nerve Block methods, Analgesics, Opioid therapeutic use, Analgesics, Opioid administration & dosage, Tablets, Treatment Outcome, Amides administration & dosage, Amides therapeutic use, Patient Satisfaction, Ropivacaine administration & dosage, Ropivacaine therapeutic use, Arthroplasty, Replacement, Knee, Pain, Postoperative drug therapy, Pain, Postoperative etiology, Sufentanil administration & dosage, Sufentanil therapeutic use, Anesthetics, Local administration & dosage, Anesthetics, Local therapeutic use
Abstract

Introduction: For several years, ropivacaine has been the standard-of-care for establishing postoperative femoral nerve block in total knee arthroplasty (TKA) setting and is still widely in use but new approaches such as the patient-controlled administration of sublingual sufentanil tablets system (SSTS) seem to offer good clinical results. Our aim is to compare the SSTS to single shot peri-nervous injection of ropivacaine (single shot) after TKA in terms of effectiveness in pain management and of time to recovery., Materials and Methods: A total of 165 patients undergoing TKA were enrolled. Eighty-four patients were randomly allocated in the SSTS group and 81 patients in the single shot group. The primary objective of the study was to evaluate performance of Timed Up and Go test. Secondary objectives were to measure the length of stay, NRS pain scale, the adherence to the prescribed plan, the joint mobility, the frequency of rescue analgesic use, side effects and patients' satisfaction., Results: Of all patients of the single shot group, 64 were withdrawn from the study as they unable to achieve pain control; only one patient was withdrawn from the SSTS group. Times for the "Timed Up and Go" test on the 3rd postoperative day were 8.4 ± 1.6 and 11.8 ± 3.6 in the SSTS group (n = 83) and single shot group (n = 17), respectively (p < .001)., Conclusions: SSTS provides better pain management when compared to peri-nervous ropivacaine single shot injection after TKA., (© 2024. The Author(s), under exclusive licence to Istituto Ortopedico Rizzoli.)

Published
2024
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25. Use of chloroprocaine in orthopedic day surgery: a brief report in a cohort of patients undergoing knee arthroscopy.

Author

Tasso F, Monteleone G, Biamino C, Lupo Pasinetti B, Giacoppo AA, De Angelis A, Simili V, Bovio M, Martorelli F, Anzillotti G, Di Matteo B, Franceschi C, Kon E, and Scardino M

Subjects
Humans, Arthroscopy adverse effects, Ambulatory Surgical Procedures adverse effects, Ambulatory Surgical Procedures methods, Retrospective Studies, Procaine adverse effects, Double-Blind Method, Anesthetics, Local, Anesthesia, Spinal methods
Abstract

Objective: Spinal anesthesia with local anesthetics is a viable alternative to general anesthesia in orthopedic surgery, and it is currently considered the standard of care for knee arthroscopy. The use of chloroprocaine may offer several potential advantages over other local anesthetics, including, above all, its rapid onset and short duration of action. The aim of the present retrospective study is to evaluate the post-surgical outcomes of patients who underwent knee arthroscopy using spinal anesthesia with chloroprocaine in an outpatient orthopedic setting., Patients and Methods: Data from patients who underwent elective knee arthroscopy between January 2022 and December 2022 were collected for the present study. Spinal anesthesia with chloroprocaine 10 mg/mL was administered in the designated subarachnoid space (L3-L4 in the majority of patients). A dosage of 40 mg was used to obtain a satisfactory sensory and motor block., Results: A total number of 302 patients met the inclusion criteria. No complications were reported during surgery in the present series of patients. None of the patients required bladder catheterization. In 84% of cases, the PADSS (Post-Anesthetic Discharge Scoring System) score at discharge was 10, whereas in 16% of cases, the PADSS score was 9. The mean time from anesthesia induction to first urination was 75±9.4 minutes, while the mean time from the anesthesia induction to the discharge from the hospital was 152±18.5 minutes., Conclusions: Spinal chloroprocaine for knee arthroscopy demonstrated a short motor block duration, resulting in a fast time to discharge. These limited data show that chloroprocaine may be safely and effectively applied in outpatient knee arthroscopy procedures. However, more studies, possibly with a randomized design, are required to confirm these findings.

Published
2023
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26. Clinical efficacy of implementing a Patient Blood Management (PBM) Protocol in joint replacement surgery: a retrospective cohort study in a national referral center.

Author

Scardino M, Di Matteo B, De Angelis A, Anzillotti G, Martorelli F, Simili V, Monteleone G, Bovio M, Tasso F, Laino ME, Tommasini T, Savevski V, Grappiolo G, Kon E, and D'Amato T

Subjects
Humans, Blood Transfusion, Hemoglobins analysis, Length of Stay, Referral and Consultation, Retrospective Studies, Treatment Outcome, Clinical Protocols, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Abstract

Objective: The aging of population has dramatically broadened the total number of Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA) performed worldwide. To optimize the number of blood transfusions performed, a multimodal and multidisciplinary approach was introduced, called Patient Blood Management (PBM). The aim of the present retrospective study is to evaluate the feasibility and clinical outcomes of a PBM protocol applied in a national referral center for joint replacement surgery., Patients and Methods: Clinical reports of 9,635 patients undergoing primary THA or TKA, from 2014 to 2019, were screened. The trends of hemoglobin value at admission and at day 4 after surgery were analyzed. Furthermore, the trend of blood bags' requests and blood transfusions was longitudinally evaluated to assess the efficacy of our PBM protocol and its potential impact in reducing the length of stay in the hospital., Results: In 2014, mean hemoglobin (Hb) levels at postoperative day 4 were 10.3 g/dl and 10.2 g/dl for TKA (unilateral and bilateral, respectively), and in 2019 were 11.3 g/dl and 11.6 g/dl (unilateral and bilateral, respectively, p=0.001). Total requested red blood cell (RBC) transfusions by each surgery over time have decreased for THA (277 in 2014 vs. 120 in 2019, p=0.001).  A correlation matrix analysis between Hb level, body mass index (BMI), age, days spent in orthopedic (OR) ward and number of requested transfusions showed that RBC bags transfusions were related to the length of the hospital stay., Conclusions: A timely application of a PBM protocol in the perioperative period of TKA and THA was significantly associated to the reduction of blood transfusions and total length of hospital stay, with clear benefits for both the patients and the hospital.

Published
2022
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27. A rapid recovery protocol for hip and knee replacement surgery: a report of the outcomes in a referral center.

Author

Tasso F, Simili V, Di Matteo B, Monteleone G, Martorelli F, De Angelis A, D'Amato T, Bovio M, Altomare D, Campofreda G, Marcacci M, and Scardino M

Subjects
Humans, Length of Stay, Referral and Consultation, Retrospective Studies, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Knee adverse effects
Abstract

Objective: The number of joint replacements is expected to dramatically increase, and the optimization of the available resources is fundamental to maintain high clinical standards while providing an efficient treatment to an increasing number of patients. The present study describes the outcomes of the application of a rapid recovery (RR) protocol in a referral center for hip and knee replacement surgery., Patients and Methods: The medical records of every patient undergoing primary hip or knee replacement in 2019 were identified and all the relevant data were retrospectively extracted and compared to those of year 2016 (the last year before the onset of the rapid recovery protocol). The following outcomes were considered: 1) length of stay (LOS); 2) total number of TKR and THR; 3) pre- and post-operative subjective questionnaires; 4) NRS for pain at day 1 following surgery; 5) mean hemoglobin value at discharge; 6) number of blood transfusion performed; 7) complications following surgery., Results: The mean LOS was significantly lower for patients managed through the rapid recovery protocol: 5.1 ± 1.4 days vs. 10.4 ± 2.3 days (p < 0.0001). The earlier discharge of patients promoted an overall increase in the total number of joint replacement procedures performed (2,806 in year 2019 vs. 2,236 in year 2016; p < 0.0001). Higher hemoglobin values at discharge were found in the RR group (10.6 ± 1.4 g/dl vs. 9.6 ± 1.2 g/dl, p = 0.049). No difference was observed in terms of clinical scores and overall complication rate., Conclusions: The application of a multimodal RR protocol for THR and TKR patients was able to reduce the length of stay and optimize the use of blood products, without increasing the risk of complications or jeopardizing the functional recovery.

Published
2022
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28. PAIP 2019: Liver cancer segmentation challenge.

Author

Kim YJ, Jang H, Lee K, Park S, Min SG, Hong C, Park JH, Lee K, Kim J, Hong W, Jung H, Liu Y, Rajkumar H, Khened M, Krishnamurthi G, Yang S, Wang X, Han CH, Kwak JT, Ma J, Tang Z, Marami B, Zeineh J, Zhao Z, Heng PA, Schmitz R, Madesta F, Rösch T, Werner R, Tian J, Puybareau E, Bovio M, Zhang X, Zhu Y, Chun SY, Jeong WK, Park P, and Choi J

Subjects
Algorithms, Humans, Image Processing, Computer-Assisted, Tumor Burden, Artificial Intelligence, Liver Neoplasms diagnostic imaging
Abstract

Pathology Artificial Intelligence Platform (PAIP) is a free research platform in support of pathological artificial intelligence (AI). The main goal of the platform is to construct a high-quality pathology learning data set that will allow greater accessibility. The PAIP Liver Cancer Segmentation Challenge, organized in conjunction with the Medical Image Computing and Computer Assisted Intervention Society (MICCAI 2019), is the first image analysis challenge to apply PAIP datasets. The goal of the challenge was to evaluate new and existing algorithms for automated detection of liver cancer in whole-slide images (WSIs). Additionally, the PAIP of this year attempted to address potential future problems of AI applicability in clinical settings. In the challenge, participants were asked to use analytical data and statistical metrics to evaluate the performance of automated algorithms in two different tasks. The participants were given the two different tasks: Task 1 involved investigating Liver Cancer Segmentation and Task 2 involved investigating Viable Tumor Burden Estimation. There was a strong correlation between high performance of teams on both tasks, in which teams that performed well on Task 1 also performed well on Task 2. After evaluation, we summarized the top 11 team's algorithms. We then gave pathological implications on the easily predicted images for cancer segmentation and the challenging images for viable tumor burden estimation. Out of the 231 participants of the PAIP challenge datasets, a total of 64 were submitted from 28 team participants. The submitted algorithms predicted the automatic segmentation on the liver cancer with WSIs to an accuracy of a score estimation of 0.78. The PAIP challenge was created in an effort to combat the lack of research that has been done to address Liver cancer using digital pathology. It remains unclear of how the applicability of AI algorithms created during the challenge can affect clinical diagnoses. However, the results of this dataset and evaluation metric provided has the potential to aid the development and benchmarking of cancer diagnosis and segmentation., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jack Zeineh is a shareholder and management of PreciseDx., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2021
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29. Impact of invasive alien plants on native plant communities and Natura 2000 habitats: State of the art, gap analysis and perspectives in Italy.

Author

Lazzaro L, Bolpagni R, Buffa G, Gentili R, Lonati M, Stinca A, Acosta ATR, Adorni M, Aleffi M, Allegrezza M, Angiolini C, Assini S, Bagella S, Bonari G, Bovio M, Bracco F, Brundu G, Caccianiga M, Carnevali L, Di Cecco V, Ceschin S, Ciaschetti G, Cogoni A, Foggi B, Frattaroli AR, Genovesi P, Gigante D, Lucchese F, Mainetti A, Mariotti M, Minissale P, Paura B, Pellizzari M, Perrino EV, Pirone G, Poggio L, Poldini L, Poponessi S, Prisco I, Prosser F, Puglisi M, Rosati L, Selvaggi A, Sottovia L, Spampinato G, Stanisci A, Venanzoni R, Viciani D, Vidali M, Villani M, and Lastrucci L

Subjects
Biodiversity, Italy, Plants, Ecosystem, Introduced Species
Abstract

Invasive alien plants are a major threat to biodiversity and they contribute to the unfavourable conservation status of habitats of interest to the European Community. In order to favour implementation of European Union Regulation no. 1143/2014 on invasive alien species, the Italian Society of Vegetation Science carried out a large survey led by a task force of 49 contributors with expertise in vegetation across all the Italian administrative regions. The survey summed up the knowledge on impact mechanisms of invasive alien plants in Italy and their outcomes on plant communities and the EU habitats of Community Interest, in accordance with Directive no. 92/43/EEC. The survey covered 241 alien plant species reported as having deleterious ecological impacts. The data collected illustrate the current state of the art, highlight the main gaps in knowledge, and suggest topics to be further investigated. In particular, the survey underlined competition as being the main mechanism of ecological impact on plant communities and Natura 2000 habitats. Of the 241 species, only Ailanthus altissima was found to exert an ecological impact on plant communities and Natura 2000 habitats in all Italian regions; while a further 20 species impact up to ten out of the 20 Italian administrative regions. Our data indicate that 84 out of 132 Natura 2000 Habitats (64%) are subjected to some degree of impact by invasive alien plants. Freshwater habitats and natural and semi-natural grassland formations were impacted by the highest number of alien species, followed by coastal sand dunes and inland dunes, and forests. Although not exhaustive, this research is the first example of nationwide evaluation of the ecological impacts of invasive alien plants on plant communities and Natura 2000 Habitats., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Published
2020
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30. Traumatic subarachnoid hemorrhage related to ophthalmic artery avulsion: a case report.

Author

Prior A, Allegretti L, Melloni I, Bovio M, Laganà F, Ceraudo M, and Zona G

Subjects
Aged, Computed Tomography Angiography, Diagnosis, Differential, Humans, Hydrocephalus etiology, Hydrocephalus pathology, Intracranial Aneurysm etiology, Intracranial Aneurysm pathology, Male, Subarachnoid Hemorrhage, Traumatic etiology, Subarachnoid Hemorrhage, Traumatic pathology, Hydrocephalus diagnostic imaging, Intracranial Aneurysm diagnostic imaging, Ophthalmic Artery injuries, Subarachnoid Hemorrhage, Traumatic diagnostic imaging
Abstract

We present a case of ophthalmic artery (OA) traumatic avulsion, leading to a post-traumatic subarachnoid hemorrhage (SAH) with ventricular blood invasion and hydrocephalus, mimicking an internal carotid aneurysm rupture. This is the third case of such an event reported in literature and the first without orbital fractures and optic nerve avulsion. Conservative treatment was sufficient for the avulsion, but surgery was needed for the coexisting eye luxation. Traumatic OA avulsion is a rare but possible event and should be suspected in case of basal cisterns SAH, evidence of orbital trauma and CT angiogram or angiographic absence of opacification of the OA.

Published
2018
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31. Severe vitamin D deficiency is associated with frequently observed diseases in medical inpatients.

Author

Marra A, Leoncini G, Mussap M, Bovio M, Nazzari E, Giusti M, Minuto F, Murialdo G, and Ameri P

Subjects
Aged, Biomarkers blood, Cerebrovascular Disorders complications, Female, Heart Failure complications, Humans, Hypertension complications, Infections complications, Inpatients statistics & numerical data, Length of Stay, Liver Diseases complications, Male, Middle Aged, Parathyroid Hormone blood, Prospective Studies, Risk Factors, Vitamin D analogs & derivatives, Vitamin D blood, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
Abstract

Introduction: Vitamin D deficiency consequences may go beyond altered calcium homeostasis and musculoskeletal disease. Medical inpatients are often vitamin D-deficient, but little information is available about the relation of vitamin D status with extra-skeletal disorders in this population., Methods: We analysed the relationship between the concentrations of 25-hydroxyvitamin D [25(OH)D], the marker of vitamin D status, and the conditions most commonly causing admission in 115 consecutive medical inpatients., Results: Sixty-five subjects (56.5%) had severe vitamin D deficiency [25(OH)D < 8 ng/ml]. Age (β = -0.35, p = 0.01) and hepatic disease (β = -0.21, p = 0.02) were significant correlates of 25(OH)D levels. Compared with patients with ≥ 8 ng/ml 25(OH)D, those with < 8 ng/ml 25(OH)D had significantly higher parathyroid hormone (PTH) concentrations [123 (92.7-208.2) ng/l vs. 88 (68.5-129.5) ng/l, p < 0.001], were significantly more likely to have arterial hypertension (OR 2.76, 95% CI 1.16-6.58), heart failure (HF) (OR 2.49, 95% CI 1.14-5.47), cerebrovascular disease (OR 3.23, 95% CI 1.41-7.39), and infections (OR 2.44, 95% CI 1.02-5.87), and stayed in hospital significantly longer (10 days vs. 7.5 days, p = 0.01). Only the probability of having an infection remained significantly higher in cases with severe vitamin D deficiency after adjustment for age (OR 2.41, 95% CI 1.03-5.68) and persisted after further correcting for presence of hepatic disease and PTH values (OR 2.66, 95% CI 1.03-6.88). A significant association between PTH and HF (OR 2.32, 95% CI 1.05-5.09) and length of hospitalisation (β = 0.22, p = 0.04) emerged in the fully adjusted regression models., Conclusions: Severe vitamin D deficiency is associated with commonly presenting extra-skeletal diseases in medical inpatients. With the exception of infections, this association is mainly driven by age. Additional studies are needed to determine whether vitamin D testing on admission may help stratifying specific categories of patients by clinical severity., (© 2014 John Wiley & Sons Ltd.)

Published
2014
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32. Inferior vena cava parameters predict re-admission in ischaemic heart failure.

Author

Carbone F, Bovio M, Rosa GM, Ferrando F, Scarrone A, Murialdo G, Quercioli A, Vuilleumier N, Mach F, Viazzi F, and Montecucco F

Subjects
Aged, Aged, 80 and over, Chronic Disease, Female, Follow-Up Studies, Heart Failure pathology, Humans, Male, Myocardial Ischemia pathology, Natriuretic Peptide, Brain blood, Patient Readmission, Peptide Fragments blood, Pilot Projects, Ultrasonography, Vena Cava, Inferior pathology, Heart Failure diagnostic imaging, Myocardial Ischemia diagnostic imaging, Vena Cava, Inferior diagnostic imaging
Abstract

Background: The clinical history of heart failure (HF) is usually characterized by frequent hospitalizations for decompensation. Therefore, several markers of subclinical hemodynamic congestion are under investigation for predicting early rehospitalization. In this field, the potential of ultrasound inferior vena cava (IVC) assessment has been recently investigated in HF but not yet assessed in the different aetiological categories., Material and Methods: Forty-eight patients admitted for decompensated HF (n = 25 with ischaemic heart disease [IHD] and n = 23 non-IHD) underwent biochemical examination (including NT-proBNP), echocardiography and IVC assessment by hand-carried ultrasound (HCU). During 60-day follow-up after discharge, the re-hospitalization rate for HF was recorded to investigate the predictive power of NT-proBNP and IVC assessment among the two study groups., Results: IHD and non-IHD patients with HF were similar except for gender distribution. During follow-up, 16·7% of patients were rehospitalized for decompensated HF, with higher prevalence in IHD group (28% vs. 4·3% P = 0·031). IVC assessment at discharge significantly predicted re-admission in the overall population and in IHD group, whereas NT-proBNP failed to predict rehospitalization in IHD group. In adjusted hazard ratio, only IVC min and the changes of IVC from admission significantly predicted re-admission. ROC analysis confirmed the change in IVC min as the best predictor of rehospitalization in patients with IHD., Conclusion: This pilot study showed a higher early re-admission rate in patients with HF due to IHD. In addition, the change in IVC min diameter from admission to discharge was the best predictor of re-admission in patients with IHD., (© 2014 Stichting European Society for Clinical Investigation Journal Foundation.)

Published
2014
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33. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency.

Author

Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, Ferone D, Murialdo G, and Minuto F

Subjects
Aged, Female, Hormone Replacement Therapy, Humans, Italy, Linear Models, Logistic Models, Male, Medical Records, Middle Aged, Prospective Studies, Retrospective Studies, Treatment Outcome, Vitamin D administration & dosage, Vitamin D analogs & derivatives, Vitamin D blood, Vitamins administration & dosage, Vitamins blood, Human Growth Hormone blood, Human Growth Hormone deficiency, Insulin-Like Growth Factor I metabolism, Vitamin D therapeutic use, Vitamin D Deficiency drug therapy, Vitamins therapeutic use
Abstract

Objectives: Previous studies suggested that vitamin D modulates circulating IGF1. We investigated this effect in adults and its clinical relevance in the management of GH deficiency (GHD)., Design and Methods: IGF1 levels were prospectively measured before and after 12 weeks of treatment with oral vitamin D3 (5000 or 7000 IU/week) vs no intervention in 39 subjects 61.9±7.9 years old. The frequency of IGF1 values ≥50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4±16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured., Results: Treatment with 5000 and 7000 IU vitamin D3/week significantly raised 25(OH)D by 12.7±8.4 and 13.1±6.5 ng/ml respectively (both P<0.001 vs baseline). In the 7000 IU group, IGF1 levels also significantly increased by 31.3±36.7 ng/ml (P=0.01). Neither 25(OH)D nor IGF1 significantly varied in controls. IGF1 was ≥50th percentile more frequently in GHD patients with 25(OH)D levels ≥15 than <15 ng/ml (65.9 vs 40.0%, P<0.05). Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between ≥15 ng/ml 25(OH)D and IGF1 ≥50th percentile (OR 4.4, 95% CI 1.0-18.8, P<0.05). A significant negative correlation between 25(OH)D concentrations and rhGH dose was found after correcting for age and IGF1 (β -0.042, P<0.01), but not after further adjusting for sex, thyroid, adrenal or gonadal replacement, and season (β -0.037, P=0.06)., Conclusions: Vitamin D increases circulating IGF1 in adults. As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD.

Published
2013
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34. Genetic diversity in widespread species is not congruent with species richness in alpine plant communities.

Author

Taberlet P, Zimmermann NE, Englisch T, Tribsch A, Holderegger R, Alvarez N, Niklfeld H, Coldea G, Mirek Z, Moilanen A, Ahlmer W, Marsan PA, Bona E, Bovio M, Choler P, Cieślak E, Colli L, Cristea V, Dalmas JP, Frajman B, Garraud L, Gaudeul M, Gielly L, Gutermann W, Jogan N, Kagalo AA, Korbecka G, Küpfer P, Lequette B, Letz DR, Manel S, Mansion G, Marhold K, Martini F, Negrini R, Niño F, Paun O, Pellecchia M, Perico G, Piękoś-Mirkowa H, Prosser F, Puşcaş M, Ronikier M, Scheuerer M, Schneeweiss GM, Schönswetter P, Schratt-Ehrendorfer L, Schüpfer F, Selvaggi A, Steinmann K, Thiel-Egenter C, van Loo M, Winkler M, Wohlgemuth T, Wraber T, Gugerli F, and Vellend M

Subjects
Ecosystem, Geography, Biodiversity, Genetic Variation, Plants genetics
Abstract

The Convention on Biological Diversity (CBD) aims at the conservation of all three levels of biodiversity, that is, ecosystems, species and genes. Genetic diversity represents evolutionary potential and is important for ecosystem functioning. Unfortunately, genetic diversity in natural populations is hardly considered in conservation strategies because it is difficult to measure and has been hypothesised to co-vary with species richness. This means that species richness is taken as a surrogate of genetic diversity in conservation planning, though their relationship has not been properly evaluated. We tested whether the genetic and species levels of biodiversity co-vary, using a large-scale and multi-species approach. We chose the high-mountain flora of the Alps and the Carpathians as study systems and demonstrate that species richness and genetic diversity are not correlated. Species richness thus cannot act as a surrogate for genetic diversity. Our results have important consequences for implementing the CBD when designing conservation strategies., (© 2012 Blackwell Publishing Ltd/CNRS.)

Published
2012
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36. Currarino syndrome with pelvic neuroendocrine tumor diagnosed by post-mortem genetic analysis of tissue specimens.

Author

Ciotti P, Mandich P, Bellone E, Ceppa P, Bovio M, Ameri P, Torre G, Fiocca R, and Murialdo G

Subjects
Adult, Anal Canal abnormalities, Anal Canal pathology, Carcinoma, Neuroendocrine genetics, Carcinoma, Neuroendocrine pathology, Constipation pathology, Dermoid Cyst pathology, Digestive System Abnormalities genetics, Digestive System Abnormalities pathology, Fatal Outcome, Female, Genetic Association Studies, Heterozygote, Homeodomain Proteins genetics, Humans, Magnetic Resonance Imaging, Mutation, Missense, Rectum abnormalities, Rectum pathology, Sacrum abnormalities, Sacrum pathology, Syringomyelia genetics, Syringomyelia pathology, Transcription Factors genetics, Uterus abnormalities, Uterus pathology, White People genetics, Carcinoma, Neuroendocrine diagnosis, Digestive System Abnormalities diagnosis, Genetic Testing, Pelvis pathology, Syringomyelia diagnosis
Abstract

Currarino syndrome (CS) is an autosomal dominant disorder of embryonic development characterized by the triad of anorectal abnormalities, partial sacral agenesis, and presacral mass. Mutations of the HLXB9 gene have been identified in most CS cases, but a precise genotype-phenotype correlation has not been described so far. We report the clinical case of a 44-year-old Caucasian woman with malignant neuroendocrine transformation of a pre-sacrococcygeal mass combined with bicornuate uterus, dermoid cyst of the ovaries, and chronic constipation. After the patient died, a sacrococcygeal malformation and anterior meningocele were diagnosed in her 22-year-old son. CS diagnosis was then retrospectively confirmed by molecular analysis of normal and pathological tissue specimens of the mother, with identification of a HLXB9 mutation (c.727C>T; p.R243W). CS should be considered, and genetic counseling recommended, to all patients with presacral masses. Since malignant neuroendocrine transformation of presacral mass in CS is a possible complication, even thought rare, close follow up in these patients is advisable., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2011
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37. High prevalence of vitamin D deficiency and its association with left ventricular dilation: an echocardiography study in elderly patients with chronic heart failure.

Author

Ameri P, Ronco D, Casu M, Denegri A, Bovio M, Menoni S, Ferone D, and Murialdo G

Subjects
Aged, Aged, 80 and over, Chronic Disease, Echocardiography, Female, Heart Failure physiopathology, Heart Ventricles physiopathology, Humans, Male, Vitamin D analogs & derivatives, Vitamin D blood, Vitamin D Deficiency blood, Heart Failure complications, Heart Failure diagnostic imaging, Heart Ventricles diagnostic imaging, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
Abstract

Background and Aims: Vitamin D deficiency has been associated with chronic heart failure (CHF). We evaluated vitamin D levels in relationship with New York Heart Association (NYHA) classes, N-terminal pro-brain natriuretic peptide (NT-proBNP) values and left ventricular (LV) measures in ≥60 year old patients with stable CHF. Differently from previous investigations, LV function was assessed by transthoracic echocardiography, to provide easily reproducible results., Methods and Results: The study was performed at geographic latitude 44° N, from March to May and from September to November 2008. Acute HF and diseases or drugs altering vitamin D status were exclusion criteria. NYHA scores and 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D and NT-proBNP concentrations were assessed in 90 (45 F, 45 M) Caucasian patients with CHF secondary to hypertension and/or coronary artery disease. Vitamin D levels were also measured in 31 subjects without heart disease (controls). LV echocardiography was performed in 52 (26 F, 26 M) representative patients. Vitamin D concentrations were significantly lower in CHF cases than in controls. Among subject with CHF, 97.8% presented vitamin D deficiency (25(OH)D<75 nmol/L), being severe (<25 nmol/L) in 66.7%. LV end-diastolic and end-systolic diameters were significantly longer, LV end-diastolic and end-systolic volumes bigger and fractional shortening lower in CHF patients with 25(OH)D<25 nmol/L than with 25(OH)D≥25 nmol/L (p<0.05). Log-values of 25(OH)D were negatively correlated with LV end-systolic diameter and volume (r=-0.28; p<0.05). On subgroup analysis, these results persisted only in male patients., Conclusions: In elderly CHF patients, vitamin D deficiency was highly prevalent and often severe. This first addressed echocardiography study showed a sex-specific association between vitamin D deficiency and LV dilation. Since further echocardiography data are easily obtainable, larger investigations are demanded., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2010
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38. Relationship between fatty degeneration of thigh muscles and vitamin D status in the elderly: a preliminary MRI study.

Author

Tagliafico AS, Ameri P, Bovio M, Puntoni M, Capaccio E, Murialdo G, and Martinoli C

Subjects
Aged, Analysis of Variance, Female, Gait, Humans, Image Interpretation, Computer-Assisted, Male, Muscular Atrophy pathology, Postural Balance, Software, Statistics, Nonparametric, Adipose Tissue pathology, Magnetic Resonance Imaging methods, Muscle, Skeletal pathology, Thigh, Vitamin D blood, Vitamin D Deficiency complications
Abstract

Objective: The purpose of this study was to study the relationship between fatty degeneration of thigh muscles and vitamin D status in elderly adults., Subjects and Methods: For six months, 121 patients 65 years old or older were evaluated. Myopathy, muscular impairment, and conditions influencing vitamin D status other than diet and sunlight were exclusion criteria. Twenty patients (10 men and 10 women; mean age, 77.6 years) underwent MRI. Thigh muscles were scanned from the hip to the knee with T1- and T2-weighted spin-echo sequences. Skeletal muscles were evaluated for fatty degeneration and atrophy from grade 0 to 3 (grade 0 = normal appearance, grade 3 = severe changes). The relationship between muscular fatty degeneration, 25-hydroxyvitamin D (25-OHD) levels, and scores on Tinetti scales for balance and gait were examined., Results: In the evaluation of the extensor muscles for fatty degeneration and atrophy, grade 0 was present in three patients (15%), grade 1 in 11 (55%), and grade 2 in six (30%). In the flexor muscles, grade 0 was found in one patient (5%), grade 1 in five (25%), and grade 2 in 14 (70%); grade 3 changes were not seen. Muscular fatty degeneration negatively correlated with 25-OHD levels (r = -0.50, p < 0.01) and the Tinetti scores (balance: r = -0.40, p < 0.05; gait: r = -0.50, p < 0.05). In 11 vitamin D-deficient patients (55%), there was selective complete atrophy of at least one thigh muscle. The gracilis and sartorius muscles were spared., Conclusion: In elderly adults, fatty degeneration of thigh muscles was associated with vitamin D deficiency and impaired balance and gait. Selective complete fatty degeneration of single muscles was observed.

Published
2010
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39. Severe bone disease with bilateral femur fracture in a young woman after gastrectomy for gastric polyposis with SMAD4 mutation.

Author

Ameri P, Bovio M, Mareni C, and Murialdo G

Subjects
Adult, Bone Diseases therapy, Female, Gardner Syndrome, Humans, Malnutrition etiology, Mutation, Polyps genetics, Stomach Neoplasms genetics, Bone Diseases etiology, Femoral Fractures etiology, Gastrectomy adverse effects, Polyps surgery, Smad4 Protein genetics, Stomach Neoplasms surgery
Published
2010
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