310 results on '"M. Centeno"'
Search Results
2. Primary cutaneous T-cell lymphoma not otherwise specified (NOS) with expression of cytotoxic molecules: Case report in a pediatric patient
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E. Rossetti, M. Guitter, L. Peruzzo, A.B. Cervini, M. Centeno, C. Sánchez la Rosa, L. Galluzo, C. Pennella, and M.S. Felice
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Primary cutaneous T-cell lymphomas NOS ,Hemophagocytic lymphohistiocytosis ,Double negative (CD4/CD8) primary cutaneous T-cell lymphoma ,Children ,Pediatrics ,RJ1-570 - Abstract
Primary cutaneous T-cell lymphomas NOS (CTCL not otherwise specified) involve a heterogeneous group of neoplasms that affect the skin, with no evidence of extracutaneous involvement at the time of diagnosis. The association with hemophagocytic lymphohistiocytosis (HLH) syndrome has been documented. They are rare in children, and usually are characterized by a dismal prognosis. We report an unusual case of a pediatric patient diagnosed as acute pityriasis lichenoide et varioliformis (PLEVA), with a torpid clinical course, association with HLH and a subsequent diagnosis of double negative (CD4/CD8) primary CTCL, with expression of cytotoxic molecules. more...
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- 2021
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3. Modulation of epileptic networks by transient interictal epileptic activity: A dynamic approach to simultaneous EEG-fMRI
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G.R. Iannotti, M.G. Preti, F. Grouiller, M. Carboni, P. De Stefano, F. Pittau, S. Momjian, D. Carmichael, M. Centeno, M. Seeck, C.M. Korff, K. Schaller, D. Van De Ville, and S. Vulliemoz
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EEG-fMRI ,Epilepsy ,Dynamic functional connectivity ,Pre-surgical planning ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Epileptic networks, defined as brain regions involved in epileptic brain activity, have been mapped by functional connectivity in simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) recordings. This technique allows to define brain hemodynamic changes, measured by the Blood Oxygen Level Dependent (BOLD) signal, associated to the interictal epileptic discharges (IED), which together with ictal events constitute a signature of epileptic disease. Given the highly time-varying nature of epileptic activity, a dynamic functional connectivity (dFC) analysis of EEG-fMRI data appears particularly suitable, having the potential to identify transitory features of specific connections in epileptic networks. In the present study, we propose a novel method, defined dFC-EEG, that integrates dFC assessed by fMRI with the information recorded by simultaneous scalp EEG, in order to identify the connections characterised by a dynamic profile correlated with the occurrence of IED, forming the dynamic epileptic subnetwork. Ten patients with drug-resistant focal epilepsy were included, with different aetiology and showing a widespread (or multilobar) BOLD activation, defined as involving at least two distinct clusters, located in two different lobes and/or extended to the hemisphere contralateral to the epileptic focus. The epileptic focus was defined from the IED-related BOLD map. Regions involved in the occurrence of interictal epileptic activity; i.e., forming the epileptic network, were identified by a general linear model considering the timecourse of the fMRI-defined focus as main regressor. dFC between these regions was assessed with a sliding-window approach. dFC timecourses were then correlated with the sliding-window variance of the IED signal (VarIED), to identify connections whose dynamics related to the epileptic activity; i.e., the dynamic epileptic subnetwork. As expected, given the very different clinical picture of each individual, the extent of this subnetwork was highly variable across patients, but was but was reduced of at least 30% with respect to the initially identified epileptic network in 9/10 patients. The connections of the dynamic subnetwork were most commonly close to the epileptic focus, as reflected by the laterality index of the subnetwork connections, reported higher than the one within the original epileptic network. Moreover, the correlation between dFC timecourses and VarIED was predominantly positive, suggesting a strengthening of the dynamic subnetwork associated to the occurrence of IED. The integration of dFC and scalp IED offers a more specific description of the epileptic network, identifying connections strongly influenced by IED. These findings could be relevant in the pre-surgical evaluation for the resection or disconnection of the epileptogenic zone and help in reaching a better post-surgical outcome. This would be particularly important for patients characterised by a widespread pathological brain activity which challenges the surgical intervention. more...
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- 2020
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4. Estudio de shunt derecha-izquierda en la amnesia global transitoria
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J. de Francisco, F. Pujadas, M. Toledo, E. Santamarina, M. Quintana, M.C. Edo, M. Centeno, and J. Álvarez Sabín
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Resumen: Introducción: La amnesia global transitoria (AGT) es una entidad de etiopatogenia incierta. En recientes estudios se cita la posible asociación entre la AGT y el shunt derecha-izquierda (SDI). Por ello estudiamos la presencia de SDI en una serie de pacientes con AGT de nuestra población y la comparamos con otra población de pacientes con ataque isquémico transitorio (AIT). Pacientes y métodos: Recogimos de forma consecutiva 66 pacientes con AGT en los que se realizó un estudio de SDI mediante Doppler transcraneal. Comparamos las características clínicas del episodio, los factores de riesgo vascular, el antecedente de migraña, la recurrencia de AGT y la neuroimagen entre las AGT con y sin SDI. Comparamos la prevalencia de SDI con la de una serie de 59 casos de AIT de origen indeterminado. Resultados: En el grupo de AGT la prevalencia de SDI fue del 21,2%. La presencia de SDI se asoció con el antecedente de migraña (el 40 frente al 13%; p = 0,014) y una maniobra de Valsalva como factor desencadenante (el 50 frente al 14,5%; p = 0,022). Se observó una mayor frecuencia de SDI en el grupo de AIT (el 55,9 frente al 21,2%; p < 0,001). Conclusiones: La prevalencia de SDI en los pacientes con AGT es similar a la descrita en la población general, pero significativamente inferior a su prevalencia en aquellos con AIT de origen indeterminado. La asociación con una maniobra de Valsalva como desencadenante del episodio en las AGT con SDI podría implicar un mecanismo etiopatogénico en este subgrupo. Abstract: Introduction: Transient global amnesia (TGA) is a disorder of unknown aetiology. In recent studies, TGA was associated with a right to left shunt (RLS). We studied the presence of the RLS in patients with TGA and we compared this series with patients who had suffered a transient ischaemic attack (TIA). Patients and methods: We included 66 consecutive TGA patients. In these patients a transcranial Doppler was performed to determine the presence of a RLS. We collected data on the TGA episode, vascular risk factors, migraine history, recurrence of TGA and neuroimaging in patients with and without RLS. We compared the prevalence of the RLS in TGA series with 59 patients with TIA. Results: The prevalence of RLS was 21.2% in patients with TGA. The RLS was associated with the migraine history (40% versus 13%; p = 0.014) and a Valsalva manoeuvre as a triggering factor (50% versus 14.5%; p = 0.022). A greater prevalence of RLS was detected in patients with TIA (55.9% versus 21.2%; p < 0.001). Conclusions: The RLS prevalence in TGA patients is similar to the general population but significantly lower than the prevalence in TIA patients. The association with a Valsalva manoeuvre as a precipitating factor in the TGA patients with RLS could play a role in the aetiopathogenesis of the TGA. Palabras clave: Amnesia global transitoria, Shunt derecha-izquierda, Foramen oval permeable, Maniobra de Valsalva, Ataque isquémico transitorio, Keywords: Transient global amnesia, Right to left shunt, Patent foramen ovale, Valsalva manoeuvre, Transient ischaemic attack more...
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- 2010
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5. A study of right-left shunt in transient global amnesia
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J. de Francisco, F. Pujadas, M. Toledo, E. Santamarina, M. Quintana, M.C. Edo, M. Centeno, and J. Álvarez Sabín
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Transient global amnesia (TGA) is a disorder of unknown aetiology. In recent studies, TGA was associated with a right to left shunt (RLS). We studied the presence of the RLS in patients with TGA and we compared this series with patients who had suffered a transient ischaemic attack (TIA). Patients and methods: We included 66 consecutive TGA patients. In these patients a transcranial Doppler was performed to determine the presence of a RLS. We collected data on the TGA episode, vascular risk factors, migraine history, recurrence of TGA and neuroimaging in patients with and without RLS. We compared the prevalence of the RLS in TGA series with 59 patients with TIA. Results: The prevalence of RLS was 21.2% in patients with TGA. The RLS was associated with the migraine history (40% versus 13%; p=0.014) and a Valsalva manoeuvre as a triggering factor (50% versus 14.5%; p=0.022). A greater prevalence of RLS was detected in patients with TIA (55.9% versus 21.2%; p more...
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- 2010
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6. Performance Analysis of Encryption Algorithms on Smartwatches.
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Joseph Kyle M. Centeno, Prabhmehar S. Chhabra, Chynna L. Fianza, Isabel Montes-Austria, and Roel Ocampo
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- 2018
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7. Testing an Adapted Auditory Verbal Learning Test Paradigm for fMRI to Lateralize Verbal Memory in Patients with Epilepsy
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E. Conde-Blanco, J.C. Pariente, M. Carreño, T. Boget, S. Pascual-Díaz, M. Centeno, I. Manzanares, A. Donaire, L. Pintor, J. Rumià, P. Roldán, X. Setoain, and N. Bargalló
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Epilepsy ,Epilepsy, Temporal Lobe ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Neurology (clinical) ,Verbal Learning ,Neuropsychological Tests ,Magnetic Resonance Imaging ,Functional Laterality - Abstract
fMRI is a noninvasive tool for predicting postsurgical deficits in candidates with pharmacoresistant temporal lobe epilepsy. We aimed to test an adapted paradigm of the Rey Auditory Verbal Learning Test to evaluate differences in memory laterality indexes between patients and healthy controls and its association with neuropsychological scores.We performed a prospective study of 50 patients with temporal lobe epilepsy and 22 healthy controls. Participants underwent a block design language and memory fMRI. Laterality indexes and the hippocampal anterior-posterior index were calculated. Language and memory lateralization was organized into typical and atypical on the basis of laterality indexes. A neuropsychological assessment was performed with a median time from fMRI of 8 months and was compared with fMRI performance.We studied 40 patients with left temporal lobe epilepsy and 10 with right temporal lobe epilepsy. Typical language occurred in 65.3% of patients and 90.9% of healthy controls (The adapted Rey Auditory Verbal Learning Test paradigm fMRI might support verbal memory lateralization. Temporal lobe epilepsy laterality influences hippocampal memory laterality indexes. Left temporal lobe epilepsy has shown a higher proportion of atypical verbal memory compared with language, potentially to memory functional reorganization. more...
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- 2022
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8. Impact of accessibility on O&M of floating offshore wind turbines: Sensitivity of the deployment site
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M. Centeno-Telleria, J.I. Aizpurua, and M. Penalba
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- 2022
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9. Primary cutaneous T-cell lymphoma not otherwise specified (NOS) with expression of cytotoxic molecules: Case report in a pediatric patient
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Maria S. Felice, M. Centeno, E. Rossetti, C. Sánchez la Rosa, L. Galluzo, Myriam Guitter, Andrea Bettina Cervini, Carla L Pennella, and L. Peruzzo
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Hemophagocytic lymphohistiocytosis ,medicine.medical_specialty ,business.industry ,Not Otherwise Specified ,Primary cutaneous T-cell lymphomas NOS ,Clinical course ,Hematology ,Pityriasis ,medicine.disease ,Primary cutaneous T-cell lymphoma ,Pediatrics ,Dermatology ,RJ1-570 ,Pediatric patient ,Oncology ,hemic and lymphatic diseases ,Pediatrics, Perinatology and Child Health ,medicine ,Double negative (CD4/CD8) primary cutaneous T-cell lymphoma ,Cytotoxic molecules ,business ,Children ,CD8 - Abstract
Primary cutaneous T-cell lymphomas NOS (CTCL not otherwise specified) involve a heterogeneous group of neoplasms that affect the skin, with no evidence of extracutaneous involvement at the time of diagnosis. The association with hemophagocytic lymphohistiocytosis (HLH) syndrome has been documented. They are rare in children, and usually are characterized by a dismal prognosis. We report an unusual case of a pediatric patient diagnosed as acute pityriasis lichenoide et varioliformis (PLEVA), with a torpid clinical course, association with HLH and a subsequent diagnosis of double negative (CD4/CD8) primary CTCL, with expression of cytotoxic molecules. more...
- Published
- 2021
- Full Text
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10. Microbialites: Diversity Hotspots in the Mexican Plateau
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Patricia M. Valdespino-Castillo, Bernardo Águila, Jesús Torres-Huesca, Carla M. Centeno, Jesus Martínez-Díaz, Margarita Reyes-Salas, Sonia Angeles-García, Yislem Beltrán, Rocío J. Alcántara-Hernández, Hoi-Ying N. Holman, and Luisa I. Falcón more...
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- 2022
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11. Cohort of patients with hypertrophic cardiomyopathy and alpha tropomyosin 1 variants followed up at a national reference center
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R Alvarez Garcia-Roves, M A Espinosa Castro, A I Fernandez, I Mendez Fernandez, M Centeno Jimenez, M Lopez Blazquez, N Vazquez Aguilera, C Relano Garcia, C Medrano Lopez, and J Bermejo Thomas
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Cardiology and Cardiovascular Medicine - Abstract
Background Hypertrophic cardiomyopathy (HCM), the most common inherited cardiac condition, is mainly caused by pathogenic variants in sarcomeric genes. Alpha tropomyosin gene (TPM1) account for a small percentage (1–5%) of HCM cases with ∼20 relevant variants described so far related to this condition. However, TPM1–hypertrophic cardiomyopathy is thought to be associated with high rates of heart failure and sudden death (SD). Purpose To describe the phenotype and genotype of a cohort of adult and pediatric patients with HCM and variants in TPM1 followed up in an inherited cardiovascular disease program of a national reference center. Methods Patients with HCM and TPM1 variants potentially related to the phenotype were retrospectively identified. Genetic test was performed by next generation sequencing panels or clinical exome. Clinical data, any need of intervention (obstruction relief, device implantation, heart transplant) and major adverse cardiovascular events were collected from medical records. We performed co-segregation studies whenever possible. Predictive models in order to support the possible pathogenicity of the variants were also applied. Results We identified 13 individuals (54% females) from 11 families with HCM and variants in TPM1. 12 patients had phenotype and one was a carrier. 5 out of 12 patients (42%) were diagnosed before the age of 12 years, all with severe phenotype. The most frequent pattern was asymmetric septal hypertrophy, with a mean thickness of the septum of 22 mm (range 14–37). 4 cases were obstructive, of which 3 required surgical myectomy. 4 patients required an implanted cardiac defibrillator (ICD), all in childhood. One was in secondary prevention after an aborted SD in a 12-year-old girl. 3 appropriate therapies were recorded in 2 patients during follow-up. A girl underwent heart transplantation at the age of 12 because of angina at rest. At last evaluation 67% were symptomatic, with 3 patients in functional class II and 5 patients in functional class III-IV/IV. 8 missense variants in TPM1 were identified in the 11 families (table 1). All variants are described in Clinvar as variants of unknown significance (VUS). They appear at a very low frequency ( Conclusion This study provides cosegregation data and “in silico” analysis of the potential functional impact of several TPM1 variants, supporting their pathogenicity. In our cohort, HCM related to TMP1 variants is associated with high penetrance (92%), early onset and poor clinical course in childhood and youth. Funding Acknowledgement Type of funding sources: None. Figure 1 more...
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- 2021
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12. Clinical epidemiology and outcomes of ventilator-associated pneumonia in critically ill adult patients: protocol for a large-scale systematic review and planned meta-analysis
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Russel Salvador Abalos-Fabia, John Mark M. Gutiérrez, Monina Hernandez, Mae M. Centeno, Annabelle R. Borromeo, John Anthony Domantay, Allan L. Dueño, Mary Grace C. Lacanaria, Emmanuel D. Paragas, Rosanta O. Ellasus, Arnel E. Sonido, Jose Reinhard C. Laoingco, Alain Jason A. Generale, Jerry A. Abriam, and Roberto C. Sombillo more...
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Adult ,medicine.medical_specialty ,Critical Illness ,Medicine (miscellaneous) ,Critical care nursing ,lcsh:Medicine ,CINAHL ,03 medical and health sciences ,0302 clinical medicine ,Intensive care ,Clinical endpoint ,medicine ,Protocol ,Humans ,Ventilator-associated pneumonia ,030212 general & internal medicine ,Intensive care medicine ,Risk assessment ,Protocol (science) ,business.industry ,030503 health policy & services ,Clinical epidemiology ,lcsh:R ,Pneumonia, Ventilator-Associated ,Odds ratio ,Predictive analytics ,medicine.disease ,Respiration, Artificial ,Intensive Care Units ,Meta-analysis ,Prognostic review ,Risk factors ,Systematic review ,0305 other medical science ,business - Abstract
Background An increasing number of studies have investigated the clinical epidemiology and outcomes of ventilator-associated pneumonia (VAP) in intensive care units. However, these findings have not been clearly defined in broad subgroups of mechanically ventilated adults. Hence, this protocol for a systematic review and meta-analysis is designed to better understand the clinical and epidemiological features of VAP in these patient populations by establishing its overall prognosis of and risk factors for morbidity and mortality and to determine the differences in clinical and economic outcomes between VAP and non-VAP patients. Methods This present review will systematically search available full-text articles without date and language restrictions and indexed in PubMed, CENTRAL, CINAHL, Web of Science, and EMBASE databases. In addition, reference lists and citations of retrieved articles and relevant medical and nursing journals will be manually reviewed. Supplementary search in other databases involving trials, reviews, and grey literatures, including conference proceedings, theses, and dissertations, will be performed. Study investigators will be contacted to clarify missing or unpublished data. All prognostic studies meeting the pre-defined eligibility criteria will be included. The study selection, risk of bias assessment, data extraction, and grading of the quality of evidence will be carried out in duplicate, involving independent evaluation by two investigators with consensus or a third-party adjudication. The degree of inter-rater agreement will be calculated using the kappa statistic. For meta-analysis, dichotomous and continuous outcome measures will be pooled using odds ratios and standardized mean differences with 95% confidence intervals, respectively. The Mantel-Haenszel or inverse variance methods with random effects model will be used as a guide for analysis. The heterogeneity of each outcome measure will be assessed using both X2 and I2 statistics. In addition, sensitivity and subgroup analyses will be performed to ensure consistency of pooled results. The review protocol described herein is in accordance with the PRISMA-P standards. Discussion The investigation of the epidemiological profiles, prognostic factors, and outcomes associated with VAP is critical for the identification of high-risk groups of mechanically ventilated patients and evaluation of possible clinical endpoints. This may provide substantial links for improved VAP prevention practices targeting modifiable risk factors. Implications for future research directions are discussed. Systematic review registration PROSPERO CRD42017048158 Electronic supplementary material The online version of this article (10.1186/s13643-019-1080-y) contains supplementary material, which is available to authorized users. more...
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- 2019
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13. Potassium channels contribute to the increased sensitivity of the rabbit carotid artery to hydrogen sulfide in diabetes
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Teresa Jover-Mengual, Alicia Aliena-Valero, María Castelló-Ruiz, Francisco J. Miranda, María C. Burguete, Mikahela A. López-Morales, and José M. Centeno
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Male ,0301 basic medicine ,Potassium Channels ,Charybdotoxin ,Carotid arteries ,Hydrogen sulfide ,Pharmacology ,Potassium channels ,Diabetes Mellitus, Experimental ,Glibenclamide ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Animals ,Hydrogen Sulfide ,Dose-Response Relationship, Drug ,Chemistry ,Diabetes ,medicine.disease ,Pathophysiology ,Potassium channel ,Vasodilation ,Carotid Arteries ,030104 developmental biology ,Rabbits ,Carotid artery ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Hydrogen sulfide (H2S) is a potential endothelium-derived hyperpolarizing factor (EDHF) and adventitium- or adipocyte-derived relaxing factor (ADRF) which vasorelaxant action is mediated by potassium channels. H2S could also play an important role in the pathophysiology of diabetic cardiovascular complications. The present study has investigated the influence of alloxan-induced diabetes on the role of potassium channels mediating the relaxant response of the rabbit carotid artery to NaHS, a donor of H2S. NaHS (10−8-3 × 10−5 M) relaxed phenylephrine-precontracted carotid arteries, with higher potency in diabetic than in control rabbits. The selective blockers of potassium channels charybdotoxin, 4-amynopiridine and glibenclamide significantly inhibited the relaxant action of NaHS in diabetic rabbits, but not in control rabbits. When compared to control rabbits, carotid arteries from diabetic rabbits showed significantly reduced expression of big conductance Ca+2-activated potassium channels (BKCa), significantly enhanced expression of intermediate conductance Ca+2-activated potassium channels (IKCa) and not significant different expression of voltage-sensitive potassium channels (KV) and ATP-sensitive potassium channels (KATP). These results suggest that an enhanced role of IKCa, KV and KATP potassium channels could be involved in the increased sensitivity of the rabbit carotid artery to H2S in diabetes. more...
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- 2019
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14. The Role of NF-κB Triggered Inflammation in Cerebral Ischemia
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Teresa Jover-Mengual, Jee-Yeon Hwang, Hyae-Ran Byun, Brenda L. Court-Vazquez, José M. Centeno, María C. Burguete, and R. Suzanne Zukin
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0301 basic medicine ,Mini Review ,Ischemia ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Context (language use) ,Inflammation ,Brain damage ,Cervell Ferides i lesions ,Neuroprotection ,NF-κB ,cerebral ischemia ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,business.industry ,Neurodegeneration ,neurodegeneration ,Inflammasome ,medicine.disease ,030104 developmental biology ,chemistry ,inflammation ,Cellular Neuroscience ,neuroprotection ,medicine.symptom ,business ,Oxigen Efectes fisiològics ,Neuroscience ,030217 neurology & neurosurgery ,RC321-571 ,medicine.drug - Abstract
Cerebral ischemia is a devastating disease that affects many people worldwide every year. The neurodegenerative damage as a consequence of oxygen and energy deprivation, to date, has no known effective treatment. The ischemic insult is followed by an inflammatory response that involves a complex interaction between inflammatory cells and molecules which play a role in the progression towards cell death. However, there is presently a matter of controversy over whether inflammation could either be involved in brain damage or be a necessary part of brain repair. The inflammatory response is triggered by inflammasomes, key multiprotein complexes that promote secretion of pro-inflammatory cytokines. An early event in post-ischemic brain tissue is the release of certain molecules and reactive oxygen species (ROS) from injured neurons which induce the expression of the nuclear factor-kappaB (NF-κB), a transcription factor involved in the activation of the inflammasome. There are conflicting observations related to the role of NF-κB. While some observe that NF-κB plays a damaging role, others suggest it to be neuroprotective in the context of cerebral ischemia, indicating the need for additional investigation. Here we discuss the dual role of the major inflammatory signaling pathways and provide a review of the latest research aiming to clarify the relationship between NF-κB mediated inflammation and neuronal death in cerebral ischemia. more...
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- 2021
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15. POS0151 PREGNANCIES IN PATIENTS WITH SPONDYLOARTHRITIS: DATA FROM 2 EUROPEAN CENTERS
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F. Crisafulli, A. R. Cruz-Machado, J. Rodrigues-Fernandes, M. C. Gerardi, S. C. Barreira, S. Grazioli, P. Martins, C. Zanardini, M. Centeno, S. Zatti, C. Araújo, L. Pinto, S. Capela, L. Andreoli, F. Franceschini, and A. Tincani more...
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Rheumatology ,Immunology ,Immunology and Allergy ,General Biochemistry, Genetics and Molecular Biology - Abstract
BackgroundThere is growing interest in reproductive issues in patients with Spondyloarthritis (SpA) and Psoriatic arthritis (PsA).ObjectivesTo describe a real-life cohort of prospectively-followed pregnancies in SpA and PsA patients, focusing on obstetric outcome and on flare during pregnancies and post-partum.MethodsData on SpA and PsA pregnancies prospectively-followed in 2 European pregnancy clinics from 2010 to 2021 were retrospectively analysed.Disease activity was assessed using ASDAS-CRP or DAS28-CRP according to the main involvement (peripheral or axial). Disease flare was defined as the need to treatment modification (introduction or increase ≥5mg/day of prednisone, introduction of cDMARD or bDMARD). Miscarriages were excluded from the analysis of flares.ResultsData on 122 pregnancies (53 PsA and 69 ‘other SpA’: 39 axialSpA, 20 undifferentiated SpA, 6 IBD-related SpA, 4 reactive arthritis) in 102 patients (median age at conception: 34 [IQR: 31-36] years; median disease duration: 72 [24-132] months) were collected.We recorded 98 (86%) live births and 16 (14%) miscarriages (8 missing data).Cesarean section was performed in 15/98 (15%) cases. Median week of gestation at delivery was 39 [38-40]; 8 preterm births (Fourty-two pregnancies (40%) had at least 1 flare during pregnancy; 7 pregnancies had more than 1 flare. Overall, there were 13, 24 and 12 flares in the 1st, 2nd and 3rd trimester, respectively.A higher frequency of patients with axial involvement was observed in the ‘flare’ group as compared to pregnancies without flare (83% vs 59%, p=0.02) (Table 1).Table 1.Comparison between ‘flare’ and ‘without flare’ groups.FLARE (42)WITHOUT FLARE (64)pAge at conception (years)33 (31-37)33 (31-35)0.88Disease duration at conception (months)71 (24-120)60 (24-137)0.74PsA13 (31%)31 (48%)0.11‘Other SpA’29 (69%)33 (52%)0.11Axial involvement35 (83%)38 (59%)0.02Peripheral involvement30 (%)54 (%)0.17bDMARD useAny time before pregnancy16 (38%)19 (30%)0.49Stop at + pregnancy test/1st trimester8 (19%)4 (6%)0.09Start/continue 1st trimester7 (17%)10 (16%)0.89Start in 2ndtrimester5 (12%)00.02Start in 3rd trimester2 (5%)00.30Post-partum flare11/34 (32%)22/49 (45%)0.36Continuous variables were compared using Mann-Whitney test; categorical variables were compared using Chi-square with Yates’ correction or Fisher’s exact test.Medications resumed to treat flare were steroids (29 pregnancies), csDMARDs (14 pregnancies) and TNF-inhibitors (7 pregnancies: 5 during the 2nd and 2 during the 3rd trimester).A post-partum flare was registered in 33/83 (40%) of cases, without difference between ‘flare’ group vs ‘without flare’ group (Table 1), as well as between PsA vs ‘other SpA’ pregnancies (47% vs 33%, p=0.2).ConclusionIn this cohort of SpA pregnancies, 40% experienced a flare during pregnancy and 40% during post-partum. Flares occurred more frequently in the 2nd trimester and especially in patients with axial involvement, requiring the start of a TNF-inhibitor during the 2nd or the 3rd trimester in 7 pregnancies. Having a flare during pregnancy was not associated with a post-partum flare.Disclosure of InterestsNone declared more...
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- 2022
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16. Narrative review of esophageal motility changes after endoscopic therapy for gastroesophageal reflux disease
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Deborah M. Centeno, Filipe Padua, Marco G. Patti, and Fernando A. M. Herbella
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Reflux ,Narrative review ,Disease ,business ,Gastroenterology ,Esophageal motility - Published
- 2021
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17. Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: A comparative study with 17β-estradiol
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Germán Torregrosa, Enrique Alborch, María Jorques, Salvador Pérez, Alicia Aliena-Valero, María C. Burguete, José M. Centeno, Francisco J. Miranda, Andrés Jurado-Rodríguez, Juan B. Salom, Mikahela A. López-Morales, María Castelló-Ruiz, Teresa Jover-Mengual, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), and Generalitat Valenciana more...
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Male ,0301 basic medicine ,MAPK/ERK pathway ,Indoles ,Signaling pathways ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Estrogen receptor ,Apoptosis ,Estrogen receptors ,Second Messenger Systems ,Biochemistry ,Brain Ischemia ,Receptors, G-Protein-Coupled ,0302 clinical medicine ,Endocrinology ,Phosphatidylinositol Phosphates ,Cerebral Cortex ,Neurons ,Estradiol ,Neuroprotection ,Stroke ,Neuroprotective Agents ,Selective estrogen receptor modulator ,Reperfusion Injury ,Molecular Medicine ,Selective estrogen receptor modulators ,GPER ,medicine.medical_specialty ,MAP Kinase Signaling System ,medicine.drug_class ,Acute ischemic stroke ,Nerve Tissue Proteins ,Bazedoxifene ,Biology ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Estrogen Receptor beta ,Rats, Wistar ,Molecular Biology ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Estrogen Receptor alpha ,Estrogens ,Cell Biology ,Estrogen ,030104 developmental biology ,030217 neurology & neurosurgery - Abstract
As the knowledge on the estrogenic system in the brain grows, the possibilities to modulate it in order to afford further neuroprotection in brain damaging disorders so do it. We have previously demonstrated the ability of the selective estrogen receptor modulator, bazedoxifene (BZA), to reduce experimental ischemic brain damage. The present study has been designed to gain insight into the molecular mechanisms involved in such a neuroprotective action by investigating: 1) stroke-induced apoptotic cell death; 2) expression of estrogen receptors (ER) ERα, ERβ and the G-protein coupled estrogen receptor (GPER); and 3) modulation of MAPK/ ERK1/2 and PI3K/Akt signaling pathways. For comparison, a parallel study was done with 17β-estradiol (E2)- treated animals. Male Wistar rats subject to transient right middle cerebral artery occlusion (tMCAO, intraluminal thread technique, 60 min), were distributed in vehicle-, BZA- (20.7 ± 2.1 ng/mL in plasma) and E2- (45.6 ± 7.8 pg/mL in plasma) treated groups. At 24 h from the onset of tMCAO, RT-PCR, Western blot and histochemical analysis were performed on brain tissue samples. Ischemia-reperfusion per se increased apoptosis as assessed by both caspase-3 activity and TUNEL-positive cell counts, which were reversed by both BZA and E2. ERα and ERβ expression, but not that of GPER, was reduced by the ischemic insult. BZA and E2 had different effects: while BZA increased both ERα and ERβ expression, E2 increased ERα expression but did not change that of ERβ. Both MAPK/ERK1/2 and PI3K/Akt pathways were stimulated under ischemic conditions. While BZA strongly reduced the increased p-ERK1/2 levels, E2 did not. Neither BZA nor E2 modified ischemia-induced increase in p-Akt levels. These results show that modulation of ERα and ERβ expression, as well as of the ERK1/2 signaling pathway accounts, at least in part, for the inhibitory effect of BZA on the stroke-induced apoptotic cell death. This lends mechanistic support to the consideration of BZA as a potential neuroprotective drug in acute ischemic stroke treatment., Supported in part by Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (RETICS networks INVICTUS (RD12/0014/ 0004) and INVICTUS+ (RD16/0019/0008), as well as grant PI12/ 00145) and by Conselleria d' Educació, Investigació, Cultura i Esport – GVA (grant GV/2015/133). more...
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- 2017
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18. Microbialites: What on Earth?
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Patricia M. Valdespino-Castillo, Yislem Beltrán, Alfredo Yanez-Montalvo, Elizabeth Selene Gómez-Acata, Carla M. Centeno, Luisa I. Falcón, and Bernardo Águila
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media_common.quotation_subject ,05 social sciences ,Art ,Archaeology ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,0501 psychology and cognitive sciences ,Earth (chemistry) ,Falcon ,computer ,030217 neurology & neurosurgery ,media_common ,computer.programming_language - Abstract
Author(s): Yanez-Montalvo, Alfredo; Aguila, Bernardo; Gomez-Acata, Elizabeth S; Beltran, Yislem; Valdespino-Castillo, Patricia M; Centeno, Carla M; Falcon, Luisa I
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- 2019
19. Novel Mutations inMLH1andMSH2Genes in Mexican Patients with Lynch Syndrome
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Víctor Maciel-Gutiérrez, Melva Gutiérrez-Angulo, Jose Miguel Moreno-Ortiz, Lucía Pérez-Carbonell, Jorge Román Corona-Rivera, Jennifer Rhees, Erin Hotchkiss, Juan Armendáriz-Borunda, María de la Luz Ayala-Madrigal, Clement Richard Boland, M. Centeno-Flores, and Ramón Franco-Topete more...
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0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Article Subject ,medicine.disease_cause ,Denaturing high performance liquid chromatography ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Germline mutation ,PMS2 ,Medicine ,lcsh:RC799-869 ,neoplasms ,Sanger sequencing ,Genetics ,Mutation ,Hepatology ,business.industry ,Gastroenterology ,nutritional and metabolic diseases ,medicine.disease ,digestive system diseases ,Lynch syndrome ,MSH6 ,030104 developmental biology ,MSH2 ,030220 oncology & carcinogenesis ,symbols ,lcsh:Diseases of the digestive system. Gastroenterology ,business ,Research Article - Abstract
Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genesMLH1,MSH2,MSH6,andPMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this study was to identify mutations inMMRgenes in three Mexican patients with LS.Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, Denaturing High Performance Liquid Chromatography (dHPLC), and Sanger sequencing complemented the analysis.Results. Two samples showed the absence of nuclear staining for MLH1 and one sample showed loss of nuclear staining for MSH2. The mutations found inMLH1gene were c.2103+1G>C in intron 18 and compound heterozygous mutants c.1852_1854delAAG (p.K618del) and c.1852_1853delinsGC (p.K618A) in exon 16. In theMSH2gene, we identified mutation c.638dupT (p.L213fs) in exon 3.Conclusions. This is the first report of mutations in MMR genes in Mexican patients with LS and these appear to be novel. more...
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- 2016
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20. Síndrome celulitis-adenitis, una forma infrecuente de presentación de la sepsis neonatal tardía. A propósito de dos casos
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Marta Morell-García, Laura Martínez-Sebastián, José M Centeno-Rubiano, Elena Montesinos-Sanchis, Nerea Sarrión-Sos, and Nelson Orta-Sibú
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Pediatrics ,medicine.medical_specialty ,Neonatal sepsis ,Streptococcus ,business.industry ,Adenitis ,medicine.disease ,medicine.disease_cause ,Group B ,Streptococcus agalactiae ,Cellulitis ,Pediatrics, Perinatology and Child Health ,medicine ,Etiology ,business ,Meningitis - Abstract
Septicemia is the main cause of neonatal mortality. The early-onset neonatal sepsis is usually related to maternal factor risks including recto-vaginal colonization. In the late-onset neonatal septicemia it is more difficult to establish the etiology because the majority of the cases are nosocomial or community related. The Streptococcus agalactiae (beta-hemolytic Streptococcus) is the most frequent germ associated with neonatal sepsis in developed countries. The late-onset form usually occurs with septic symptoms and meningitis and, in a few cases, with osteoarticular, skin and soft tissue infection. Adenitis-cellulitis syndrome is rarely seen, and its main cause is Staphylococcus aureus, followed by Streptococcus agalactiae. We report two cases of group B Streptococcus late-onset neonatal septicemia, both of them with adenitis-cellulitis syndrome. Patients recovered uneventfully after an adequate antibiotic therapy. more...
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- 2018
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21. Performance Analysis of Encryption Algorithms on Smartwatches
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Roel Ocampo, Prabhmehar S. Chhabra, Chynna L. Fianza, Joseph Kyle M. Centeno, and Isabel Montes-Austria
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Twofish ,business.industry ,Computer science ,010401 analytical chemistry ,Wearable computer ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Encryption ,01 natural sciences ,0104 chemical sciences ,law.invention ,Smartwatch ,Bluetooth ,law ,Mobile phone ,Embedded system ,Overhead (computing) ,0210 nano-technology ,business ,ElGamal encryption - Abstract
As smartwatches gain more usefulness in daily life, they handle more kinds of sensitive data. However, most of today’s smartwatches unsecurely communicate with the user’s mobile phone over Bluetooth Low Energy, leaving personal sensitive information vulnerable to security attacks. Due to the size and resource constraints in smartwatches, security features have been largely neglected. We argue that enforcing encryption as a baseline defense on smartwatch communications can be done without causing significant performance degradation and battery drainage. We implemented four different encryption algorithms (AES, Twofish, RSA, and ElGamal) on a smart-watch and evaluated their effects on the device’s battery life, memory, CPU utilization, and communication latency. We tested these algorithms on various types of data exchanged between wearables and mobile phones: simple messages, small files, and sensory data. Our experiments show that enforcing any of the encryption algorithms we evaluated has no statistically significant negative impact on the smartwatch’s performance and that the performance overhead introduced by these algorithms will not be perceptible to the user. more...
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- 2018
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22. Habitat conditions drive phylogenetic structure of dominant bacterial phyla of microbialite communities from different locations in Mexico
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Omar Mejía, Luisa I. Falcón, and Carla M. Centeno
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0301 basic medicine ,DNA, Bacterial ,Ensamble comunitario ,Cyanobacteria ,03 medical and health sciences ,Reference Values ,RNA, Ribosomal, 16S ,DNA Barcoding, Taxonomic ,community composition ,microbialitos ,Relative species abundance ,Mexico ,composición comunitaria ,Ecosystem ,Phylogeny ,NTI ,Phylogenetic tree ,biology ,Bacteria ,Community assembly ,Phylum ,Ecology ,microbialites ,Planctomycetes ,Verrucomicrobia ,Community structure ,Species diversity ,Bacteroidetes ,Eukaryota ,bacterias heterotróficas ,biology.organism_classification ,Archaea ,cianobacterias ,NRI y NTI ,Phylogeography ,030104 developmental biology ,NRI ,General Agricultural and Biological Sciences ,heterotrophic bacteria - Abstract
Community structure and composition are dictated by evolutionary and ecological assembly processes which are manifested in signals of, species diversity, species abundance and species relatedness. Analysis of species coexisting relatedness, has received attention as a tool to identify the processes that influence the composition of a community within a particular habitat. In this study, we tested if microbialite genetic composition is dependent on random events versus biological/abiotical factors. This study was based on a large genetic data set of two hypervariable regions (V5 and V6) from previously generated barcoded 16S rRNA amplicons from nine microbialite communities distributed in Northeastern, Central and Southeastern Mexico collected in May and June of 2009. Genetic data of the most abundant phyla (Proteobacteria, Planctomycetes, Verrucomicrobia, Bacteroidetes, and Cyanobacteria) were investigated in order to state the phylogenetic structure of the complete communities as well as each phylum. For the complete dataset, Webb NTI index showed positive and significant values in the nine communities analysed, where values ranged from 31.5 in Pozas Azules I to 57.2 in Bacalar Pirate Channel; meanwhile, NRI index were positive and significant in six of the nine communities analysed with values ranging from 18.1 in Pozas Azules I to 45.1 in Río Mesquites. On the other hand, when comparing each individual phylum, NTI index were positive and significant in all groups, except in Cyanobacteria for which positive and significant values were only found in three localities; finally, NRI index was significant in only a few of the comparisons performed. The results suggest that habitat filtering is the main process that drives phylogenetic structure in bacterial communities associated to microbialites with the exception of Cyanobacteria where different lineages can contribute to microbialite formation and growth. La estructura y composición de las comunidades son determinadas por procesos evolutivos y ecológicos que se manifiestan en las señales de la diversidad, abundancia y la relación de especies. El análisis de la relación de especies que coexisten ha recibido atención como una herramienta para identificar los procesos que influyen en la composición de una comunidad dentro de un hábitat particular. En este estudio, evaluamos si la composición genética de bacterias microbialíticas depende de acontecimientos al azar vs factores biológicos/ abióticos. Este estudio se basa en un conjunto de datos genéticos de dos regiones hipervariables (V5 y V6) de gen 16S rRNA generados previamente de nueve comunidades de microbialitos distribuidos en el Noreste, Centro y Sureste de México, recolectados en mayo y junio 2009. Los datos genéticos de los filos más abundantes (Proteobacteria, Planctomycetes, Verrucomicrobia, Bacteroidetes y Cianobacterias) fueron analizados para determinar la estructura filogenética de la comunidad y de cada filo por separado. Para el análisis conjunto, el índice NTI de Webb mostró valores positivos y significativos en las nueve comunidades analizadas, en donde los valores oscilaron entre 31.5 en Pozas Azules I y 57.2 en el Canal Pirata en Bacalar; en contraste, los valores del índice NRI fueron positivos y significativos en seis de las nueve comunidades analizadas con valores oscilando desde 18.1 en Pozas Azules I hasta 45.1 en Río Mezquites. Por otro lado, en la comparación de cada filo individual, el índice NTI fue positivo y significativo en todos los grupos excepto en Cyanobacteria, en donde valores positivos y significativos fueron encontrados sólo en tres localidades; finalmente, el índice NRI fue significativo sólo en unas cuantas de las comparaciones realizadas. Los resultados sugieren que el filtrado del hábitat es el proceso principal que determina la estructura filogenética de las comunidades bacterianas asociadas a microbialitos con la excepción de las cianobacterias en donde diferentes linajes pueden contribuir a la formación y crecimiento del microbialito. more...
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- 2018
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23. Diabetes modifies the role of prostanoids and potassium channels which regulate the hypereactivity of the rabbit renal artery to BNP
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María Castelló-Ruiz, Mikahela A. López-Morales, Vannina G. Marrachelli, Alicia Aliena-Valero, Enrique Alborch, Luis Miranda-Gómez, Teresa Jover-Mengual, José M. Centeno, María C. Burguete, and Francisco J. Miranda more...
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0301 basic medicine ,Male ,medicine.medical_specialty ,Potassium Channels ,medicine.drug_class ,Prostacyclin ,030204 cardiovascular system & hematology ,Prostanoids ,Diabetes Mellitus, Experimental ,Potassium channels ,Diabetic nephropathy ,Glibenclamide ,03 medical and health sciences ,Thromboxane A2 ,chemistry.chemical_compound ,0302 clinical medicine ,Renal Artery ,Diabetes mellitus ,Internal medicine ,Renal artery ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Animals ,cardiovascular diseases ,Pharmacology ,biology ,business.industry ,Diabetes ,General Medicine ,Iberiotoxin ,medicine.disease ,Vasodilation ,030104 developmental biology ,Endocrinology ,chemistry ,B-type natriuretic peptide ,biology.protein ,Prostaglandins ,cardiovascular system ,Cyclooxygenase ,Rabbits ,business ,human activities ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug ,circulatory and respiratory physiology - Abstract
Diabetic nephropathy is associated with increased risk of cardiovascular disease. B-type natriuretic peptide (BNP) plays an important role in cardiovascular pathophysiology and therapeutics. The aim of the present study was to investigate the influence of experimental diabetes on the mechanisms that regulate the relaxant response of the rabbit renal artery to BNP. Arterial relaxations to BNP were enhanced in diabetic rabbits. Indomethacin enhanced BNP-induced relaxation in control rabbits but showed no effect in diabetic rabbits. BNP-induced release of thromboxane A(2) or prostacyclin was not different in both groups of animals. Iberiotoxin had no effect on relaxations to BNP in both groups of animals. Charybdotoxin displaced to the right the concentration-response curve to BNP in both group of animals, and inhibited BNP-induced relaxation only in diabetic rabbits. Glibenclamide did not modify the BNP-induced relaxations in control rabbits, but inhibited it in diabetic rabbits. These results suggest that diabetes induces hypereactivity of the rabbit renal artery to BNP by mechanisms that at least include (1) a reduced vasoconstrictor influence of arachidonic acid metabolites via cyclooxygenase 2, which is not related with changes in thromboxane A(2) and prostacyclin release from the arterial wall and (2) a selectively increased modulatory activity of K-ATP and endothelial IKCa channels. more...
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- 2018
24. Molecular mechanisms underlying the neuroprotective role of atrial natriuretic peptide in experimental acute ischemic stroke
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Germán Torregrosa, Teresa Jover-Mengual, Juan B. Salom, José M. Centeno, Alicia Aliena-Valero, Francisco J. Miranda, María C. Burguete, Enrique Alborch, Mikahela A. López-Morales, and María Castelló-Ruiz more...
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0301 basic medicine ,MAPK/ERK pathway ,Male ,Potassium Channels ,Signaling pathways ,medicine.drug_class ,MAP Kinase Signaling System ,Acute ischemic stroke ,Down-Regulation ,Apoptosis ,Brain damage ,Pharmacology ,Biochemistry ,Neuroprotection ,Brain Ischemia ,03 medical and health sciences ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Endocrinology ,Atrial natriuretic peptide ,Natriuretic peptide ,Medicine ,Animals ,DNA Cleavage ,Rats, Wistar ,Receptor ,Molecular Biology ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Injections, Intraventricular ,business.industry ,Caspase 3 ,Natriuretic peptide receptors ,Brain ,Infarction, Middle Cerebral Artery ,Stroke ,030104 developmental biology ,Neuroprotective Agents ,Reperfusion Injury ,K+ channels ,medicine.symptom ,business ,Proto-Oncogene Proteins c-akt ,Receptors, Atrial Natriuretic Factor ,030217 neurology & neurosurgery ,Atrial Natriuretic Factor ,hormones, hormone substitutes, and hormone antagonists - Abstract
Along with its role in regulating blood pressure and fluid homeostasis, the natriuretic peptide system could be also part of an endogenous protective mechanism against brain damage. We aimed to assess the possibility that exogenous atrial natriuretic peptide (ANP) could protect against acute ischemic stroke, as well as the molecular mechanisms involved. Three groups of rats subjected to transient middle cerebral artery occlusion (tMCAO, intraluminal filament technique, 60 min) received intracerebroventricular vehicle, low-dose ANP (0.5 nmol) or high-dose ANP (2.5 nmol), at 30 min reperfusion. Neurofunctional condition, and brain infarct and edema volumes were measured at 24 h after tMCAO. Apoptotic cell death and expression of natriuretic peptide receptors (NPR-A and NPR-C), K+ channels (KATP, KV and BKCa), and PI3K/Akt and MAPK/ERK1/2 signaling pathways were analyzed. Significant improvement in neurofunctional status, associated to reduction in infarct and edema volumes, was shown in the high-dose ANP group. As to the molecular mechanisms analyzed, high-dose ANP: 1) reduced caspase-3-mediated apoptosis; 2) did not modify the expression of NPR-A and NPR-C, which had been downregulated by the ischemic insult; 3) induced a significant reversion of ischemia-downregulated KATP channel expression; and 4) induced a significant reversion of ischemia-upregulated pERK2/ERK2 expression ratio. In conclusion, ANP exerts a significant protective role in terms of both improvement of neurofunctional status and reduction in infarct volume. Modulation of ANP on some molecular mechanisms involved in ischemia-induced apoptotic cell death (KATP channels and MAPK/ERK1/2 signaling pathway) could account, at least in part, for its beneficial effect. Therefore, ANP should be considered as a potential adjunctive neuroprotective agent improving stroke outcome after successful reperfusion interventions. more...
- Published
- 2018
25. Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population
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Miriam Partida-Pérez, Ramírez-Ramírez R, Melva Gutiérrez-Angulo, A.S. Suarez-Villanueva, Muñiz-Mendoza R, Jose Miguel Moreno-Ortiz, Víctor Maciel-Gutiérrez, E. Cabrales-Vazquez, Jorge Peregrina-Sandoval, María de la Luz Ayala-Madrigal, M.T. Magana, and M. Centeno-Flores more...
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Genetics ,Linkage disequilibrium ,Oncogene ,Carcinogenesis ,Colorectal cancer ,Haplotype ,General Medicine ,Biology ,medicine.disease ,Polymorphism, Single Nucleotide ,Gene Frequency ,Case-Control Studies ,Genotype ,Trans-Activators ,medicine ,Humans ,Genetic Predisposition to Disease ,Colorectal Neoplasms ,Mexico ,Molecular Biology ,Gene ,Allele frequency ,Genotyping - Abstract
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed the 2 polymorphisms in Mexican patients with CRC. Genotyping of rs16998248 and rs35720349 sites was performed by polymerase chain reaction-restriction fragment length polymorphism in 203 Mexican Mestizos, 101 CRC patients, and 102 healthy blood donors. Although no statistical differences regarding genotype and allele frequencies of ZNF217 polymorphisms were observed (P > 0.05), linkage disequilibrium was significant in CRC patients (r(2) = 0.39, P < 0.0001), as a result of reduced AC haplotype frequency. Thus, the AC haplotype may protect against CRC. more...
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- 2015
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26. Mechanisms involved in the increased sensitivity of the rabbit basilar artery to atrial natriuretic peptide in diabetes
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Germán Torregrosa, Alicia Aliena-Valero, Francisco J. Miranda, Enrique Alborch, Juan B. Salom, María Castelló-Ruiz, María C. Burguete, José M. Centeno, Vannina G. Marrachelli, Mikahela A. López-Morales, and Teresa Jover-Mengual more...
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0301 basic medicine ,Male ,medicine.medical_specialty ,Endothelium ,medicine.drug_class ,Rabbit basilar artery ,Vasodilation ,Prostanoids ,Nitric Oxide ,Potassium channels ,Diabetes Mellitus, Experimental ,Glibenclamide ,03 medical and health sciences ,Cerebral circulation ,Atrial natriuretic peptide ,medicine.artery ,Internal medicine ,medicine ,Basilar artery ,Natriuretic peptide ,Animals ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,Diabetes ,Nitric oxide ,Iberiotoxin ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Basilar Artery ,cardiovascular system ,Prostaglandins ,Rabbits ,business ,Receptors, Atrial Natriuretic Factor ,hormones, hormone substitutes, and hormone antagonists ,Atrial Natriuretic Factor ,medicine.drug - Abstract
Atrial natriuretic peptide (ANP) is a vasodilator with significant regional differences and controversial effects in the cerebral circulation, a vascular bed particularly prone to diabetes-induced complications. The present study has investigated how alloxan-induced diabetes modifies the mechanisms involved in the response of the rabbit basilar artery to ANP. ANP (10(-12) -10(-7) M) relaxed precontracted basilar arteries, with higher potency in diabetic than in control rabbits. In arteries from both groups of animals, endothelium removal reduced ANP-induced relaxations. Inhibition of NO-synthesis attenuated ANP-induced relaxation but this attenuation was lower in diabetic than in control rabbits. In control rabbits, indomethacin displaced to the left the concentration-response curve to ANP, without significantly modifying the E-max value. In diabetic rabbits, indomethacin significantly enhanced arterial relaxations to ANP. In KCl-depolarised arteries, relaxation to ANP was almost abolished both in control and in diabetic rabbits. Iberiotoxin inhibited relaxations to ANP in both groups of rabbits. Glibenclamide and 4-aminopyridine inhibited the ANP-induced relaxations more in diabetic than in control rabbits. Basilar arteries from diabetic rabbits showed decreased natriuretic peptide receptor C expression and no changes in natriuretic peptide receptor A, large conductance calcium-activated K+ channels (BKCa), ATP-sensitive K+ channels (KATP) and voltage-sensitive K+ channels (K-V) expression. These results suggest that diabetes enhances the sensitivity of the rabbit basilar artery to ANP by mechanisms that at least include reduced expression of natriuretic peptide receptor C, and enhanced activity of KATP and KV channels. Furthermore, diabetes reduces endothelial NO and prostacyclin which mediate arterial relaxation to ANP. more...
- Published
- 2017
27. Comparative Study of Polyacrylamide Co-polymers for EOR at High Salinity Conditions 'Laboratory and Simulation
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Pedro Diaz, M Centeno, and A. Breda
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Salinity ,chemistry.chemical_classification ,chemistry.chemical_compound ,Flow conditions ,Shear thinning ,Petroleum engineering ,chemistry ,Rheology ,Chemical engineering ,Polyacrylamide ,Newtonian fluid ,Polymer ,Produced water - Abstract
Summary: The success of polymer flooding as a method of oil recovery has been attributed to a profile control mechanism of the displacing fluid (polymer solutions) related to the displaced fluid (crude oil), depending on properties such as polymer viscosity and its dependence with reservoir and flow conditions. The viscosity of polymer flow depends not only on the size of the molecules or molecular weight but it is further affected by salinity and divalent content on the brine used for the preparation of the polymer slug. The effect of salinity on polymer viscosity is more critical in presence of divalent ions Ca2+ and Mg2+ and high salinity conditions, which limits the use high salinity produced water for re-injection in polymer flooding processes where high salinity is involved. A series of salinity resistant polymers have been developed by incorporating co-monomers including hydrophilic and hydrophobic groups or combination of them along the chain of polyacrylamide which has made the viscosity behavior more complex and affected by ionic interactions both intra-molecular and inter-molecular. Therefore, an extensively screening process that includes evaluation of variables such as: stability of polymer solutions under salinity and ion composition, flow conditions and sensitivity analysis using simulation according to specific applications, is required for the selection of any specific system. A systematic comparative study of the screening of commercial partial hydrolysed polyacrylamide (PHPA), and co-polymers of acrylamide and hydrophobic modified Comb-polymers (HMPAM) under high salinity conditions is investigated. Synthetic high salinity and multi-component (with divalent ions) produced water from a North Sea reservoir was used on Bernheimer sandstone core samples using a crude oil from the North Sea with specific gravity 21 oAPI. Results from core flooding and rheology were matched to obtain required mathematical correlations to simulate core flooding experiments numerically and compare the efficiency of the different polymers. While polymers PHPA and co-polymers AM-AMPS and AM-nVP showed typical Newtonian behavior at low shear rates and non- Newtonian at high shear rates, HMPAM polymers have shear thinning behavior. Newtonian behavior on PHPA-3 seems to support its higher recovery factor comparing with PHPA-6 (higher MW). Viscosity of HMPAM solutions is more sensitive to changes of the polymer concentration and more sensible to flow conditions. Additionally, ionic interactions and steric effects in the co-polymers contribute the efficiency of the oil recovery at high salinity. Therefore, their viscosity behavior needs to be evaluated. more...
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- 2017
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28. Application of Low Concentration Surfactant Enhanced Water-Alternating-Gas Flooding
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M Eneotu, Pedro Diaz, I. Sagbana, F Vajihi, M Centeno, and A Farhadi
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Surface tension ,Hydrogeology ,Petroleum engineering ,Pulmonary surfactant ,Water alternating gas ,Enhanced oil recovery ,Relative permeability ,Petroleum reservoir ,Volume concentration ,Geology - Abstract
Large amounts of oil left in the petroleum reservoir after primary and secondary enhanced oil recovery methods have brought about the implementation of several tertiary means of oil recovery. Increment of oil recovery can support the world’s oil supply. Water alternating gas injection has been a very popular method of gas injection to improving volumetric sweep efficiency. Although water alternating as injection has been shown to improve oil recovery, this process suffers inherent challenges such as water blocking, mobility control in high viscosity oil and gravity segregation. To combat these problems associated with water alternating gas flooding, the use of surfactant has been employed in water alternating gas injection. Due to the high operational cost arising from chemical cost in surfactant alternating gas injection, a new technique which involves the injection of low concentration surfactant before water alternating as flooding has been proposed. This work investigates experimental and numerical oil recovery potential of surfactant enhanced water alternating gas flooding. The distinctive feature of this technique is that instead of injecting surfactant slugs alternatively with gas, which will result to using a greater amount of surfactant, a low concentration surfactant is injected into the reservoir before water alternating gas flooding. The aim is to evaluate the performance of this technique as a low cost and effective means of chemically enhanced oil recovery by combining both mechanisms of surfactant reduction of water-oil interfacial tension and creation of foam with gas. This study begins with surfactant evaluation to characterise surfactants compatibility with reservoir brine and oil. Then followed by series core flooding experiments which include waterflooding, gas flooding, water alternating gas flooding and surfactant-enhanced water alternating gas flooding. Core flood data was history matched for water alternating as flooding and surfactant-enhanced water alternating as flooding via commercial simulator by inputting relative permeability curves, rock, fluid properties and interfacial tension. The results showed that experimentally, surfactant enhanced water alternating as flooding had the highest oil recovery when compared to conventional enhanced oil recovery methods. History matching of core flood experiment predicted similar increment in oil recovery during surfactant enhanced WAG. The effectiveness of this technique is based on the injection pattern after the initial surfactant injection and oil recovery potential is similar to that of surfactant alternating gas flooding. more...
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- 2017
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29. Genetic diversity associated with N-cycle pathways in microbialites from Lake Alchichica, Mexico
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Martín Merino-Ibarra, Luisa I. Falcón, Rocio J. Alcántara-Hernández, Patricia M. Valdespino-Castillo, Carla M. Centeno, and Javier Alcocer
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0301 basic medicine ,Cyanobacteria ,Denitrification ,Aquatic Science ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,N-2 fixation ,N cycle ,Botany ,Ecology, Evolution, Behavior and Systematics ,Heterocyst ,biology ,Ecology ,Microbialites ,Nitrogenase ,Ammonia monooxygenase ,biology.organism_classification ,Marine Biology & Hydrobiology ,030104 developmental biology ,Nitrite oxidoreductase ,chemistry ,Anammox ,Nitrification - Abstract
Author(s): Alcantara-Hernandez, RJ; Valdespino-Castillo, PM; Centeno, CM; Alcocer, J; Merino-Ibarra, M; Falcon, LI | Abstract: Microbialites are an example of complex and diverse microbial assemblages where several metabolic pathways are interconnected for biomass formation coupled to mineral precipitation. Lake Alchichica (Mexico) is an oligotrophic environment where nitrogen (N) and phosphorus alternately limit productivity, and massive microbialite growths are found along the lake's perimeter. Previous studies have described the importance of N2 fixation in these microbialites, although other pathways associated with the N cycle, including denitrification, nitrification and anaerobic ammonium oxidation (anammox), had not been evaluated. This study identified the genetic diversity associated with N cycling in both metagenomic DNA and RNA expression by targeting key genes for nitrogenase (nifH), ammonia monooxygenase (amoA), nitrite oxidoreductase (nxrA, nxrB), hydrazine oxidoreductase (hzo) and nitrite (nirS and nirK) and nitrous oxide (nosZ) reductases. While the genetic potential for N2 fixation, ammonia oxidation, anammox and denitrification was present in the microbialites of Lake Alchichica, the most transcribed pathway was N2 fixation. more...
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- 2017
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30. Transitional Care Models
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Kellie L. Kahveci and Mae M. Centeno
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medicine.medical_specialty ,High risk patients ,business.industry ,digestive, oral, and skin physiology ,Emergency medicine ,Health care ,Medicine ,Transitional care ,Multiple Chronic Conditions ,Critical Care Nursing ,business ,Community hospital - Abstract
Transition from hospital to home is a vulnerable period for older adults with multiple chronic conditions. A pilot of the Transitional Care Model at a community hospital reduced readmission rates for patients with heart failure by 48%. This article shares the experience of a large metropolitan health care system in expanding transitional care across facilities to decrease readmission rates. more...
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- 2014
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31. The selective estrogen receptor modulator, bazedoxifene, reduces ischemic brain damage in male rat
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María Castelló-Ruiz, Germán Torregrosa, Teresa Gasull, José M. Centeno, Mikahela A. López-Morales, María C. Burguete, Enrique Alborch, and Francisco J. Miranda
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Brain Infarction ,Male ,Selective Estrogen Receptor Modulators ,medicine.medical_specialty ,Indoles ,medicine.drug_class ,Ischemia ,Hemodynamics ,Postmenopausal osteoporosis ,Neuroprotection ,Bazedoxifene ,Ischemic brain ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Estradiol ,business.industry ,General Neuroscience ,Brain ,medicine.disease ,Neuroprotective Agents ,Endocrinology ,Ischemic Attack, Transient ,Selective estrogen receptor modulator ,Estrogen ,business ,medicine.drug - Abstract
While the estrogen treatment of stroke is under debate, selective estrogen receptor modulators (SERMs) arise as a promising alternative. We hypothesize that bazedoxifene (acetate, BZA), a third generation SERM approved for the treatment of postmenopausal osteoporosis, reduces ischemic brain damage in a rat model of transient focal cerebral ischemia. For comparative purposes, the neuroprotective effect of 17β-estradiol (E2) has also been assessed. Male Wistar rats underwent 60min middle cerebral artery occlusion (intraluminal thread technique), and grouped according to treatment: vehicle-, E2- and BZA-treated rats. Optimal plasma concentrations of E2 (45.6±7.8pg/ml) and BZA (20.7±2.1ng/ml) were achieved 4h after onset of ischemia, and maintained until the end of the procedure (24h). Neurofunctional score and volume of the damaged brain regions were the main end points. At 24h after ischemia-reperfusion, neurofunctional examination of the animals did not show significant differences among the three experimental groups. By contrast, both E2- and BZA-treated groups showed significantly lower total infarct volumes, BZA acting mainly in the cortical region and E2 acting mainly at the subcortical level. Our results demonstrate that: (1) E2 at physiological plasma levels in female rats is neuroprotective in male rats when given at the acute stage of the ischemic challenge and (2) BZA at clinically relevant plasma levels mimics the neuroprotective action of E2 and could be, therefore, a candidate in stroke treatment. more...
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- 2014
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32. Miscarriage history andToxoplasma gondii infection: A cross-sectional study in women in Durango City, Mexico
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Sandy Janet Pacheco-Vega, Cosme Alvarado-Esquivel, Isabel Beristain-Garcia, M. M. Centeno-Tinoco, Jesús Hernández-Tinoco, Luis Omar Berumen-Segovia, Elizabeth Rábago-Sánchez, Luis Francisco Sánchez-Anguiano, and Oliver Liesenfeld more...
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medicine.medical_specialty ,biology ,business.industry ,Cross-sectional study ,Obstetrics ,Public health ,Toxoplasma gondii ,biology.organism_classification ,Logistic regression ,medicine.disease ,Miscarriage ,parasitic diseases ,Immunology ,Epidemiology ,Seroprevalence ,Medicine ,Original Article ,business ,Socioeconomic status - Abstract
Through a cross-sectional study design, 326 women with a history of miscarriage were examined for anti-Toxoplasma gondii IgG and IgM antibodies in Durango City, Mexico. Prevalence association with sociodemographic, clinical, and behavioral characteristics in women with miscarriage was also investigated. Twenty-two (6.7%) of the 326 women studied had anti-T. gondii IgG antibodies and two (0.6%) were also positive for anti-T. gondii IgM antibodies. Seroprevalence of T. gondii infection was not influenced by age, birth place, occupation, educational level, or socioeconomic status. In contrast, logistic regression showed that T. gondii exposure was associated with consumption of raw or undercooked meat (OR = 6.84; 95% CI: 1.04-44.95; P = 0.04) and consumption of chicken brains (OR = 18.48; 95% CI: 1.26-269.43; P = 0.03). This is the first study on the seroepidemiology of T. gondii infection in women with a history of miscarriage in Northern Mexico. Of interest, we also observed an association of T. gondii exposure with consumption of chicken brains. Contributing factors for T. gondii exposure found in the present study should be taken into consideration for public health measures to avoid infection with T. gondii and its sequelae. more...
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- 2014
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33. Assessment of emotional discomfort of oncological patients in the first nursing visit at Donostia University Hospital
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M. Salort, P. Rodriguez, L. Moreno, M. Centeno, M.J. Esnaola, L. Basterretxea, A. Valverde, E. Uranga, O. Aizpurua, M. Otalora, H. Telleria, and M.A. Landa
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Social work ,Referral ,business.industry ,Conflict of interest ,Hematology ,Disease ,Oncology ,Quality of life ,Nursing ,Medicine ,Anxiety ,medicine.symptom ,Radiation treatment planning ,business ,Psychosocial - Abstract
Background A cancer diagnosis often causes an emotional impact with signs of anxiety, uncertainty and subjective discomfort. It´s necessary to identify and assess emotional discomfort to offer quality treatment articulated around the patient and his / her demand. The design of a questionnaire that is easy to use and understand, allows the detection of patients susceptible to referral to the Psycho-oncology Unit (POU). Methods - Prepare a PAQ that includes: Evaluation of emotional distress assisted by visual analogue scales (VAS); Modified Gijon scale (sociofamilar assessment scale); previous use of psychoactive drugs - Include PAQ in the first nursing visit - Quick referral to POU - Interview with psycho-oncology nurse - Valuation, diagnosis and treatment planning by POU - Data recording - Data analysis. Results Patients with a positive PAQ are referred to the POU where the liaison nurse performs an interview with the patient and / or family. The nurse collects data on psychobiography, oncological disease, psychic sphere, frequent affections, previous contacts with psychologists / psychiatrists and treatments with psychoactive drugs. The POU will offer the patient the most appropriate resource for their needs (Psychotherapy, Psychopharmaceuticals, and Social Work Service). Conclusions The inclusion of the PAQ in the first visit of nursing allows the detection and early treatment of disorders in the psychosocial area. We achieve an optimal use of resources, a greater adherence to the proposed oncological treatment, alleviate problems that are found throughout the oncological treatment and improve the quality of life of our patients by reducing emotional discomfort. Legal entity responsible for the study The authors. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest. more...
- Published
- 2019
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34. Characterization and comparison of potential denitrifiers in microbial mats from King George Island, Maritime Antarctica
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Rocio J. Alcántara-Hernández, Martín Merino-Ibarra, Luisa I. Falcón, Alejandro Ponce-Mendoza, Silvia Cristina Freitas Batista, Julio Campo, and Carla M. Centeno
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Denitrifying bacteria ,Water column ,Denitrification ,Benthic zone ,Microorganism ,Botany ,Gammaproteobacteria ,Microbial mat ,Biology ,General Agricultural and Biological Sciences ,biology.organism_classification ,Temperature gradient gel electrophoresis - Abstract
Cyanobacterial microbial mats are highly structured communities commonly found in Antarctic inland waters including melt streams. These benthic microbial associations comprise a large number of microorganisms with different metabolic capacities, impacting nutrient dynamics where established. The denitrification process is a feasible nitrogen loss pathway and a biological source of nitrous oxide, a potent greenhouse gas that also promotes ozone depletion. Potential denitrifiers from five microbial mats were characterized using a PCR-DGGE (denaturing gradient gel electrophoresis) approach. Molecular markers encoding for key enzymes in the denitrification process (nirK, nirS and nosZ) were used. Fingerprints were obtained for the five sampled mats and compared for two successive years. Distance analysis showed that despite the sampled year, the denitrifying genetic potential was similar between most of the sites when represented in Euclidean space. The number of dominant denitrifiers detected for each sample ranged between 6 and 18 for nirK, 4–10 for nirS and 6–17 for nosZ. The seventy-two sequenced phylotypes showed 80–98 % identity to previously reported environmental sequences from water column, sediments and soil samples. These results suggest that Antarctic microbial mats have a large denitrification potential, previously uncharacterized and composed by both site-specific and common phylotypes belonging mainly to Alpha-, Beta- and Gammaproteobacteria. more...
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- 2013
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35. Involvement of prostacyclin and potassium channels in the diabetes-induced hyporeactivity of the rabbit carotid artery to B-type natriuretic peptide
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Teresa Jover-Mengual, Luis Miranda, Francisco J. Miranda, Germán Torregrosa, Enrique Alborch, María C. Burguete, José M. Centeno, María Castelló-Ruiz, Vannina G. Marrachelli, and Juan B. Salom
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Blood Glucose ,Male ,medicine.medical_specialty ,Potassium Channels ,Endothelium ,medicine.drug_class ,Prostacyclin ,Nitric Oxide ,Glibenclamide ,Thromboxane A2 ,chemistry.chemical_compound ,Diabetes mellitus ,Internal medicine ,Natriuretic Peptide, Brain ,Diabetes Mellitus ,medicine ,Natriuretic peptide ,Animals ,cardiovascular diseases ,Endothelial dysfunction ,Stroke ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,Body Weight ,medicine.disease ,Epoprostenol ,Peptide Fragments ,Carotid Arteries ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Potassium ,cardiovascular system ,Rabbits ,business ,Receptors, Atrial Natriuretic Factor ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
The relation between diabetes and stroke is bidirectional: diabetes is an important risk factor for ischemic stroke, and acute stroke frequently induces hyperglycemia. On the other hand, plasma B-type natriuretic peptide (BNP) levels are raised in diabetes and stroke. The purpose was to study how alloxan-induced diabetes might modify the effects of BNP in rabbit carotid arteries and the mechanisms involved in such actions. To do this, isometric tension in isolated rabbit carotid artery was recorded and prostanoids release and plasma NT-proBNP were measured by enzyme immunoassay. BNP induced a relaxation of phenylephrine-precontracted carotid arteries, and this relaxation was lower in diabetic than in control rabbits. Endothelium removal did not modify the relaxation to BNP in control rabbits but increased this relaxation in diabetic rabbits. In control rabbits, indomethacin inhibited the BNP-induced relaxation in the presence and in the absence of endothelium. In diabetic rabbits, indomethacin did not modify the BNP-induced relaxation in arteries with endothelium and inhibited it in arteries without endothelium. In the presence of BNP the carotid artery released thromboxane A2 and prostacyclin, and the release of endothelial prostacyclin was inhibited in diabetic rabbits. Glibenclamide and 4-aminopyridine inhibited the relaxation to BNP, and these inhibitions were lower in diabetic than in control rabbits. In conclusion, our results provide a new understanding concerning the mechanisms of the diabetes-induced hyporeactivity of the carotid artery to BNP, that at least include the loss of endothelial prostacyclin and a reduced participation of ATP-sensitive K(+) channels (KATP) and voltage-sensitive K(+) channels (KV). more...
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- 2013
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36. Evaluation of Ultra Low Concentration Surfactant System for Chemical Flooding
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Pedro Diaz, M Centeno, and I. Sagbana
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chemistry.chemical_classification ,Sodium ,chemistry.chemical_element ,Mineralogy ,Divalent ,chemistry.chemical_compound ,Sulfonate ,chemistry ,Chemical engineering ,Pulmonary surfactant ,Alkoxy group ,Microemulsion ,Enhanced oil recovery ,Sulfate ,Geology - Abstract
In order to select a surfactant formulation for chemical flooding, the surfactant has to be evaluated at reservoir conditions to determine its compatibility with the reservoir to be injected in. This is to avoid formation of gels and precipitation in the reservoir which can make surfactant enhanced oil recovery unsuccessful. In several studies, surfactants have been tested in the laboratory at room temperature using only sodium chloride salt in the brine. While in oilfield scenario, the temperature is higher and the reservoir brine contains divalent ions. In this study, very low concentration alcohol alkoxy sulfate with and without a co-surfactant in hard brine and medium crude oil has been evaluated. The results from the salinity scan, phase behaviour and core flooding experiments at 60°C shows that alcohol alkoxy sulfate is tolerant to divalent ions and its stability can be improved with the addition of methyl ester sulfonate and internal olefin sulfonate as co-surfactants. These co-surfactants were able to reduce the viscosity of microemulsion phase, create a lower interfacial tension by increasing solubilisation ratio and also increase oil recovery by at least 20%. more...
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- 2016
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37. Final report. SIM comparison in mass standards SIM.M.M-K4
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Claude Jacques, Fr Garcia, Fe Garcia, L. Luján, L. M. Centeno, Janepsy Diáz, Fernando Kornblit, F. Cacais, L. M. Peña, V. M. Loayza, Joselaine Cáceres, Ramos Olman, S Sanjuán Rodríguez, Fernando Leyton, Luis Omar Becerra, Claudia Santo, and J. Leiblich more...
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General Engineering - Abstract
This report summarizes the results of a SIM comparison of a 1 kg mass standard carried out by 7 NMIs. The results reported by the participants are consistent with each other and they can be linked to the comparison CCM.M-K4 with satisfactory degrees of equivalence. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA). more...
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- 2016
38. El manejo emocional en docentes granadinos en relación a la satisfacción en el trabajo
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Alicia Herrera Ojea, Carmen N. Machado Castilla, Govinda L. López Vidaurre, Aida M. Centeno Barrera, and Laura Trujillo Patón
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Applied Mathematics ,General Mathematics - Abstract
espanolEl proposito de este estudio descriptivo, que ha contado con 40 sujetos, es conocer la relacion entre las diferentes dimensiones de la satisfaccion en el trabajo y la inteligencia emocional en una muestra de profesores de dos Institutos de Educacion Secundaria de Granada. Se ha realizado utilizando el Cuestionario de Satisfaccion Laboral S20/23 y el TMMS-24 que mide la inteligencia emocional. Tras un analisis de los datos obtenidos, se ha podido comprobar que no existia correlacion alguna entre nuestras variables y, por otro lado, que no habia diferencias significativas. Es por esto que no se da evidencia a favor de la literatura anterior y, con ello, se aportan cuales son las limitaciones del presente estudio para intentar ver cual es el motivo de estos resultados EnglishThe purpose of this descriptive study, in which 40 subjects participated, is to determine the relationship between different aspects of job satisfaction and emotional intelligence in a sample of Secondary School teachers from Granada. Two questionnaires were used including the Job Satisfaction Questionnaire S20/23 and the TMMS-24. The data analysis shows that there was no correlation between these variables and that there were no significant differences. No evidence was found supporting the earlier literature, hence the inclusion of the limitations of the present study in an attempt to determine the underlying cause of the outcome. more...
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- 2016
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39. Poster Session Wednesday 5 December all day Display * Determinants of left ventricular performance
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J. Skranes, I. Andreadou, A. Germain, A. Alghamdi, C. Santoro, Z. Markovic, G. Jones, N. Lousada, K. Shahgaldi, A. Iqbal, L. Carpinteiro, O. Dzikowska-Diduch, J. Khoo, H. Vago, Y. Juilliere, M. L. Del Pino, M. Lisi, J. Choi, Y. Yotov, M. Monaghan, P. Seferovic, R. Beanlands, K. Dima, J. Suarez De Lezo Herreros De Tejada, I. D-Angeli, S. Veioglanis, A. Magalhaes, R. Esposito, D. Damaskos, L. Faber, M. Centeno, A. Sahlen, A. Stoylen, K. Adamyan, R. Gao, C. Zito, M. Gomez-Rubin, A. Simon, N. Markovic Nikolic, J. Gibbs, J. Dahl, S. Gati, A. Omran, K. Aonuma, B. Michalski, B. Zweig, V. Katsi, S. Giannitsi, S. Wrideier, D. Marcadet, S. Malm, S. Rahman Haley, B. Rybus-Kalinowska, S. Yurdakul, N. Haas, C. Katseli, M. Caplin, D. Haghi, L. Drvol, S. Bosi, M. M. Gurzun, B. Merkely, T. Alvarez, L. Capotosto, G. Draganic, C. Lowery, D. J. Cuthbertson, T. Kovats, S. Gherardi, F. Elmkies, H.-J. Trappe, S. Backovic, A. Koumoulidis, W. Sheng, S. G. Da Silva, M. Alam, I. Felekos, L. Badano, A. Manouras, W. Burchert, H. Direskeneli, M. Alraies, B. Natali, L. Weinert, A. Scullion, Y. Noguchi, K. Chun, M. Borggrefe, A. Barbieri, S. Hassantash, M. Banovic, M. Takeuchi, E. Sfendouraki, D. Horstkotte, W. Gin-Sing, K. Gatzoulis, W. Choi, K. Grudzka, G. Luzza, J. Sellal, M. Galderisi, C. Halley, O. Hallioglu, T. Sueselbeck, A. Nagy, S. Eroglu, N. Mansencal, H. Seggewiss, V. Kuznetsov, M. Anastasiou-Nana, M. Lourenco, W. Jaber, L. Howard, S. Piret, P. Palczewski, A. Mohamed, R. Dekemp, S. Habash, L. Videbaek, B. Kilicaslan, E. Nestaas, C. Marin, C. Selton-Suty, I. Ikonomidis, G. Sjoberg, L. Stefanczyk, S. Goliszek, A. Charalampopoulos, A. Travlou, V. Pipitone, N. Matveeva, T. G. Alujas, K. Ananthasubramaniam, M. Karvandi, D. Ermacora, A. Rodriguez-Ogando, J. Silva Marques, J. Kim, L. Michalis, M. Prull, O. Wendler, J. Chattahi, M. Baldelli, J.-L. Philip, A. Squeri, D. Jiminez, I. Tzoulaki, J. Hallberg, G. Truscelli, P. Zinzius, L. Santos, D. Tousoulis, I. B. Surribas, B. Stojcevski, C. Reverberi, S. Ghani, F. Toledano Delgado, D. Han, M. Hedger, I. Ilic-Djordjevic, S. Berthier, B. Tasdelen, G. Pushkarev, P. Maccarthy, M. Cikes, L. Arnold, M. Ostojic, A. Massoni, D. Fugelseth, K. Szymczyk, F. Caranci, Y. Seo, O. Kunchev, E. Picano, A. Nunes Diogo, V. Vukcevic, S. Martins, C. Doesch, M. Chiavarelli, M. Petrovic, O. Enescu, H. Al-Shehri, D. Cini, M. Kalinowski, A. Zaidi, T. Song, Z. Cosic, S. Lupu, I. Koutagiar, J. Stabryla, S. Rangamani, M. Ciurzynski, C. Medrano, L. Tong, A. Ylitalo, J. Sanderson, B. Prendergast, L. R. Tumasyan, E. Gunyeli, F. Castillo Bernal, A. Vershinina, M. Krupa, A. Madaffari, D. Ledoux, M. Ozeren, A. Baltabaeva, A. Mladenovic, T. Christophersen, T. Papavassiliu, C. Yu, P. Lipiec, M. Fischer, D. Bacic, A. Padiyath, I. Paraskevaidis, T. Kukulski, M. Stamatelatou, H. Houle, S. Sideris, G. Kolunin, S. Boedeker, K.-L. Ang, G. A. Derumeaux, L. Agoston-Coldea, M. Baeza Garzon, B. Buyukakilli, S. Antoniou, A. Buno, G. Roussakis, L. Sargento, A. Ouss, M. Losito, O. Azevedo, M. M. Urdaniz, G. Arpesella, B. Lichodziejewska, B. Vujisic-Tesic, T. Butz, J. Davar, M. Poulsen, A. Grasso, G. Gkiouras, J. Moller, A. Apor, O. Dettori, T. Ruddy, W. Aljaroudi, G. Saifullina, C. Mabbet, N. Sheikh, M. De Maio, R. Sharma, G. Sutherland, J. Sun, M. Frenneaux, A. Saitta, D. Mahadevan, A. Angelov, F. Maffessanti, C. Gouva, A. Almeida, W. Serra, G. Tamborini, R. Winter, R. Medeiros, R. Ionasec, L. Gapon, P. Carrilho Ferreira, E. Ramirez, D. Roberson, A. Sadykov, R. P. Dos Reis, M. Burgess, P. Bruno, J. Hamilton, A. E. Masip, F. Oner, A. Erraki, M. Naldi, M. Massetti, C. Calisto, J. Lopez-Sendon, S. Gao, E. Kartsagoulis, J. Lof, D. Muraru, J. Kwong, V. Muthurangu, F. Degener, B. Bijnens, R. Arunkumar, S. Ranjbar, S. Longo, M. Pietila, W. Streb, T. Bombardini, H. Zemir, D. Silva, Q. Zhang, S. Lee, K. Naka, F. Vecchio, F. Schaefer, C. Marcos, A. Kottam, L. Brunvand, A. Burghardt, M. Satendra, I. Machado, M. Toth, J. Nowak, G. Gnanavelu, S. Stojkovic, E. Maroto, Y. Park, S. Coulibaly, N. Ozgunes, O. Oldenburg, S. Gurgul, M. Canales, T. Rudbaek, T. Lopez-Fernandez, P. Katsimbri, M. Dekleva, F. Liu, J. Thomas, L. Garcia Cuenllas, P. Meimoun, K. Egstrup, T. Mocan, J. Coghlan, R. Bader, B. Loegstrup, F. Barilla, S. Ribeiro, S. Akhunova, F. Sibellas, C. Aggeli, N. Swaminathan, I. Zyrianov, D. Citirik, J. Suzic Lazic, A. Lourenco, A. Cox, S. Tzortzis, G. Makavos, M. Szulik, P. Massion, R. Sicari, B. Wozniakowski, B. Bahlay, A. Rosner, S. Kutty, J. Lekakis, R. Tripodi, D. Hofsten, M. Pepi, J. Davies, D. Trifunovic, B. Sasko, A. Bircan, M. Camino, J. Stepanovic, A. Bernardes, P. Marie, S. H. Kim, R. Dulgheru, S. Aytekin, B. Pencic, I. Papadakis, G. Dwivedi, D. Danford, J. Sousa, R. Klein, P. Pruszczyk, M. Altman, J. Schwartz, F. De Torres, A. Sahinarslan, A. Moysich, A. Chilingaryan, P. Goktas, N. Cortez-Dias, M. Maccherini, M. Mpougialkli, K. Kurnicka, L.-A. Mohlkert, M D Mesa Rubio, E. Imbalzano, O. Huttin, T. Kiviniemi, P. Wiesen, M. Norman, A. Sezgin, B. Pirat, M. Mercy, N. Shurkevich, J. Clerc, A. Pereira, K. Katopodis, P. Dilaveris, A. Saraste, A. Kisheva, B. Chow, S. Sahin, A. Ionescu, C. Toumpanakis, A. Rudd, J. Srinivasan, S. Chachalos, T. Kuehne, X. Liu, S. Mihaila, A. Aydinalp, T. Ishizu, M. Cameli, G. Pavlidis, A. Aussoleil, M. Hussein, F. Streitner, H. Schirmer, J.-C. Eicher, C. Bergerot, L. A. Pierard, A. Chernjavskiy, H. Raju, S. Mondillo, A. Taylor, S. Carerj, T. Lehtinen, C. Stefanadis, D. Chin, C. Barreiros, R. Davies, M. Schumann, R. Riezebos, D. Gemma, R. Capoulade, B. Montalvan, A. Ciobanu, J. D'hooge, D. I. Del Valle, J. Feliu, D. Duman, D. Donato, D. G. Dorado, V. Bistola, J. B. Rius, M. Kleut, T. Myrmel, M. Bessonova, F. Ballesteros, M. Delgado Ortega, I. Grapsa, C. Papadopoulos, P. Pellikka, D. Muthukumar, A. Flyvbjerg, H. Triantafyllidi, M. Al-Mallah, L. Mircheva, I. Quelhas, R. Rimbas, M. Boricic, J. F. R. Palomares, J. Kasprzak, M. Ravi, Y. Harimura, F. Sargin, V. Dhandapani, D. Knight, J.-L. Canivet, N. Kouris, A. Sljivic, R. A. Dobson, G. Nartsissova, G. T. Tura, P. Trivilou, C. Sousa, I. Ali, C. Jorge, S. Chidambaram, A. Rotkiewicz, R. Grimm, K. Yun, E. Yaroslavskaya, E. Poulidakis, O. Dubourg, P. Lancellotti, D. Dedovic, H. Muderrisoglu, P. Pibarot, A. Rodriguez, A. Vitarelli, D. Kececioglu, R. Placido, P. T. Mas, C. Halvorsen, F. Fang, M. van Bracht, M. Galinanes, A. Toth, Z. Kalarus, M. Ruiz Ortiz, M. Bjerre, J.-E. Wolf, A. Majstorovic, G. Karthikeyan, N. D. Papamichael, E. Szymczyk, I. Kallikazaros, S. Singh, S. Venkatesan, A. Chan, A. Stevanovic, L. Sade, L. G. Garcia-Moreno, B. Lorcerie, A. Tsantes, M. Loudon, C. Olympios, B. K. Avci, K. Laser, Y. Feng, H. Koerperich, L. Rodriguez, I. Schilling, A. Avgeropoulou, S. Goncalves, J. Guardado, R. Reynolds, V. De Cicco, V. Kostopoulos, D. Karassavidou, R. Lang, S. Stankovic, S. Granja, H. Thibault, L. Rasmussen, C. Prinz, N. Banner, F. Mazuelos, E. Bonnefoy-Cudraz, R. Jasaityte, B. Popovic, L. Li, R. Del Bene, P. Karjalainen, W. Tsang, I. Vlasseros, P. Gripari, S. Binno, K. Airaksinen, V. Celic, J. Magne, D. Krinochkin, E. Ferdenzi, D. Avenarius, K. Meenakshi, D. Vinereanu, Z. Elhonsali, S. Sharma, J. D'arcy, D. Dawson, M. Cusma-Piccione, A. Inan, A. Rodriguez Lopez, G. M. Nasr, M. Kostrubiec, D. Iaccarino, H. Botker, M. Morenate Navio, V. Cui, and A. Luycx-Bore more...
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medicine.medical_specialty ,business.industry ,Physical therapy ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
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40. Some actual trends in Medical Education
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Carlos Alberto Brailovsky and Ángel M Centeno
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formación profesional ,multiprofesionalismo ,selección ,admisión ,aprendizaje a distancia ,evaluación ,Education - Abstract
Sincethe "Flexneriane" revolution 100 years ago, many attempts have been made to change how medicine is taught, and many new general tendencies in education have appeared. Principally the necessity to surpass the classic biomedical model with one more focussed on the individual and society has become evident. The curriculum tends to be more comprehensive with the inclusion of community needs, integration different clinical dimensions and interpersonal skills. The selection and admission of students into medical schools seeks to be more inclusive, equalising and based on the science of evaluation. Models of virtual universities have been emerging which will surely be successful in the future. They are based on the constant development of simulators, new information technology and the use of social media networks. There are many examples of mixed models of distance learning and blended e- learning. The concept of multi-professional and inter-professional practice and training including undergraduate and postgraduate training in some schools according to selected orientation has been incorporated. Evaluation of knowledge and professional skills tends to be more descriptive, with an emphasis on reflection and on metacognitive skills as well as the use of sophisticated tests such as OSCE, miniCEX, and Script Concordance tests. Educational training has become longitudinal, reflexive, interactive and encourages personal and professional commitment as an element for learning. Many aspects of medical education are definitely changing and these new tendencies are a medium through which one can adapt to the new social realities. more...
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- 2012
41. El tiempo de la responsabilidad social de las Escuelas de Medicina
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Ángel M Centeno and Ana Belén del Río
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educación médica y sociedad ,Social accountability of universities ,accreditation of medical schools ,acreditación escuelas de medicina ,medical education and society ,Responsabilidad social universitaria ,Education - Abstract
En las últimasdécadas se ha revigorizado el debate en torno al rol de las universidades en las sociedades de las cuales forman parte. A esto se suma la idea de la responsabilidadsocialuniversitaria (RSU), la cual toma como eje el rol de las universidades en el desarrollo de su contexto social en sus tres funciones principales: la docencia, la inevstigación y elservicio. Las transformaciones en las ciencias de la salud han promovido su reflexión en torno a este tema y se han desarrollado en los últimos años acciones tendientes a su implementación tales como la definición de la responsabilidad social para las escuelas de medicina y actividades para promover el consenso en tópicos centrales como la asistencia, la educación y la investigación. Asimismo, este consenso sienta las bases para repensar los estándares de acreditación de las carreras de medicina. El desafío en el futuro próximo es poner en acción aquello que ya se ha debatido y acordado a nivel global, es decir, pasar de la idea y de la planificación a la acción.ABSTRACTThe time of the social responsibility of medicine schools.In the last decades the debate about the role of university in the society has invigorated, and it has included the concept of social responsibility and social accountability of the university, that considers the development of the university in its context based on its three basic components: teaching, research and service. The transformations of the health sciences promoted reflections on this topic and there have been many actions oriented to put this concept into practice, such as the definition of social accountability, the activities to promote consensus on items as service, education and research. Besides, this consensus set the basis to revisit the accreditation standards of medical schools. The next challenge will be to implement those actions that have been decided following the model of conceptualization, planning and implementation. more...
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- 2012
42. Microbialite genetic diversity and composition relate to environmental variables
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Yislem Beltrán, Pierre Legendre, Ulrika Lidstrom, Matthew Ashby, Carla M. Centeno, Luisa I. Falcón, and Rocio J. Alcántara-Hernández
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media_common.quotation_subject ,Fresh Water ,RNA, Archaeal ,Biology ,Applied Microbiology and Biotechnology ,Microbiology ,Extant taxon ,RNA, Ribosomal, 16S ,Genetic variation ,Mexico ,Phylogeny ,media_common ,Genetic diversity ,Bacteria ,Ecology ,Fossils ,Phylum ,Genetic Variation ,Biodiversity ,Archaea ,Biological Evolution ,Environmental effect ,Lakes ,RNA, Bacterial ,Microbial genetics ,Pyrosequencing ,human activities ,Diversity (politics) - Abstract
Microbialites have played an important role in the early history of life on Earth. Their fossilized forms represent the oldest evidence of life on our planet dating back to 3500 Ma. Extant microbialites have been suggested to be highly productive and diverse communities with an evident role in the cycling of major elements, and in contributing to carbonate precipitation. Although their ecological and evolutionary importance has been recognized, the study of their genetic diversity is yet scanty. The main goal of this study was to analyse microbial genetic diversity of microbialites living in different types of environments throughout Mexico, including desert ponds, coastal lagoons and a crater-lake. We followed a pyrosequencing approach of hypervariable regions of the 16S rRNA gene. Results showed that microbialite communities were very diverse ( H ′ = 6–7) and showed geographic variation in composition, as well as an environmental effect related to pH and conductivity, which together explained 33% of the genetic variation. All microbialites had similar proportions of major bacterial and archaeal phyla. more...
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- 2012
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43. N2 fixation rates and associated diversity (nifH) of microbialite and mat-forming consortia from different aquatic environments in Mexico
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Pierre Legendre, Yislem Beltrán, Luisa I. Falcón, Carla M. Centeno, and Felipe García-Oliva
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Cyanobacteria ,Community ,Ecology ,food and beverages ,Nitrogenase ,Aquatic Science ,Biology ,biology.organism_classification ,Fixation (population genetics) ,Oscillatoriales ,Diazotroph ,Microbial mat ,Chroococcales ,Ecology, Evolution, Behavior and Systematics - Abstract
The present study describes patterns and rates of N2 fixation and associated diversity (based on the nifH gene) of microbialite and mat-forming bacterial consortia from different aquatic environments in Mexico. All of the communities shared a diurnal pattern of N2 fixation with peak activity during the day while showing a unique genetic composition. Our study sug- gests the importance of heterocystous cyanobacteria as the main diazotrophic organisms, although nifH sequences were also affiliated to Oscillatoriales, Chroococcales, and several Pro- teobacteria. Genetic composition did not relate to the environmental variables analysed, although rates of nitrogenase activity associated to microbial C and N explained 11% of the variation among consortia. more...
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- 2012
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44. Cerebrovascular Effects of Dotarizine, a Piperazine Derivative, in the Goat
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Juan B. Salom, E Alborch, J M Centeno, M Ortí, M D Barberá, and Germán Torregrosa
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Chemistry ,Dotarizine ,Cerebral arteries ,Pharmacology ,Cerebral circulation ,Cerebral blood flow ,In vivo ,Anesthesia ,medicine.artery ,Drug Discovery ,Middle cerebral artery ,medicine ,medicine.symptom ,Cerebral perfusion pressure ,Vasoconstriction ,medicine.drug - Abstract
The effects of dotarizine (1-(diphenylmethyl)-4-[3-(2-phenyl-1,3- dioxolan-2-yl)propyl]-piperazine, CAS 84625-59-2) on the cerebral circulation of goats were assessed in vivo by recording continuously global cerebral blood flow (gCBF) and cortical perfusion (CP), and in vitro by recording isometric tension in goat isolated middle cerebral artery (MCA). Administration of dotarizine (1 microgram-5 mg) directly into the cerebroarterial supply of goats produced transient increases in gCBF and CP, and decreases in cerebral vascular resistance (CVR) which were significant for the highest doses tested: 1, 3 and 5 mg. On the other hand, cumulative addition of increasing concentrations of dotarizine (10(-8)-3 x 10(-5) mol/l) to MCA segments subjected to the resting tone of 1 g did not induce sizeable changes in vascular tension; by contrast, dotarizine elicited concentration-dependent relaxations of MCA segments subjected to the active tone induced by either 5-hydroxytryptamine (10(-6) mol/l) or high-K+ medium (50 mmol/l). These results show that dotarizine exerts a direct relaxant action on cerebral arteries, which results in an improvement of cerebral perfusion. more...
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- 2011
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45. Pulmonary Arterial Hypertension
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Mae M. Centeno
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medicine.medical_specialty ,Medical treatment ,business.industry ,Hypertension, Pulmonary ,Treatment options ,Disease ,Critical Care Nursing ,medicine.disease ,Risk Assessment ,Pulmonary hypertension ,Social support ,Blood pressure ,Chronic disease ,Internal medicine ,Cardiology ,Humans ,Medicine ,Familial Primary Pulmonary Hypertension ,Risks and benefits ,business ,Intensive care medicine ,Nursing Assessment - Abstract
PAH is a chronic disease requiring lifelong therapy, regardless of chosen treatment options. Nurses and other providers must allow for open, honest discussion on the risks and benefits of each therapy. Determining the best treatment option for patients requires consideration of the patient's overall function and social support. These patients benefit from comprehensive and collaborative support from facilities or centers trained in the management of the disease. more...
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- 2011
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46. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area
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X. Luo, F. Fang, J. Sun, J. Xie, A. Lee, Q. Zhang, C. Yu, O. Breithardt, S. Schiessl, M. Schmid, M. Seltmann, L. Klinghammer, C. Zeissler, M. Kuechle, W. Daniel, M. Ege, U. Guray, Y. Guray, B. Demirkan, H. Kisacik, S.-E. Kim, J.-Y. Hong, J.-H. Lee, D.-G. Park, K.-R. Han, D.-J. Oh, O. Tufekcioglu, D. C. Cozma, C. Mornos, A. Ionac, L. Petrescu, C. Tutuianu, S. I. Dragulescu, L. Guimaraes, G. Tavares, A. Rodrigues, C. Nagamatsu, C. Fischer, M. Vieira, W. Oliveira, T. Wilberg, A. Cordovil, S. Morhy, D. Muraru, M. Peluso, L. Dal Bianco, M. Beraldo, E. Solda', M. Tuveri, U. Cucchini, A. Al Mamary, L. Badano, S. Iliceto, A. Pizzuti, B. Mabritto, C. Derosa, A. Tomasello, M. Rovere, I. Parrini, M. Conte, N. Lareva, A. Govorin, R. Cooper, J. Sharif, J. D. Somauroo, J. D. Hung, V. Porcelli, R. Skevington, A. Shahzad, S. Scott, P. Lindqvist, S. Soderberg, M. Gonzalez, E. Tossavainen, M. Henein, N. Nciri, H. Saad, S. Nawas, A. Ali, A. Youssufzay, A. Safi, S. Faruk, S. Yurdakul, V. Erdemir, Y. Tayyareci, O. Yildirimturk, K. Memic, V. Aytekin, M. Gurel, S. Aytekin, M. Przewlocka-Kosmala, M. Cielecka-Prynda, A. Mysiak, W. Kosmala, S. Pescariu, D. Cozma, A. Mornos, S. Dragulescu, N. Maurea, C. G. Tocchetti, C. Coppola, C. Quintavalle, D. Rea, A. Barbieri, G. Piscopo, C. Arra, G. Condorelli, R. Iaffaioli, H. Dalen, A. Thorstensen, H. Moelmen, H. Torp, A. Stoylen, D. Augustine, C. Basagiannis, J. Suttie, P. Cox, R. Aitzaz, A. Lewandowski, M. Lazdam, C. Holloway, H. Becher, P. Leeson, S. Radovanovic, A. Djokovic, B. Todic, M. Zdravkovic, M. Zaja-Simic, S. Banicevic, D. Lisulov-Popovic, M. Krotin, J. Grapsa, D. O'regan, D. Dawson, G. Durighel, L. Howard, J. Gibbs, P. Nihoyannopoulos, C. Tulunay Kaya, M. Kilickap, H. Kurklu, N. Ozbek, C. Koca, V. Kozluca, K. Esenboga, C. Erol, B. Kusmierczyk-Droszcz, E. Kowalik, J. Niewiadomska, P. Hoffman, M. Satendra, L. Sargento, S. Lopes, S. Longo, N. Lousada, R. Palma Reis, P. Chillo, A. Rieck, J. Lwakatare, J. Lutale, E. Gerdts, S. Bonapace, G. Molon, G. Targher, A. Rossi, L. Lanzoni, G. Canali, E. Campopiano, L. Zenari, L. Bertolini, E. Barbieri, K. Hristova, L. Vladiomirova-Kitova, T. Katova, F. Nikolov, P. Nikolov, S. Georgieva, I. Simova, V. Kostova, V. A. Kuznetsov, D. V. Krinochkin, P. A. Chandraratna, Y. A. Pak, E. H. Zakharova, A. V. Plusnin, M. V. Semukhin, E. A. Gorbatenko, E. I. Yaroslavskaya, G. Bedetti, L. Gargani, M. Scalese, C. Pizzi, R. Sicari, E. Picano, M. Reali, E. Canali, S. Cimino, M. Francone, M. Mancone, R. Scardala, F. Boccalini, Y. Hiramoto, A. Frustaci, L. Agati, K. Savino, A. Lilli, E. Bordoni, C. Riccini, G. Ambrosio, D. Silva, N. Cortez-Dias, P. Carrilho-Ferreira, C. Jorge, J. Silva-Marques, A. Magalhaes, L. Santos, S. Ribeiro, F. Pinto, A. Nunes Diogo, E. Kinova, N. Zlatareva, A. Goudev, C. Bonanad, M. Lopez-Lereu, J. Monmeneu, V. Bodi, J. Sanchis, J. Nunez, F. Chaustre, A. Llacer, D. Ermacora, D. Peluso, M. Di Lazzari, P. Meimoun, F. Elmkies, T. Benali, J. Boulanger, H. Zemir, J. Clerc, A. Luycx-Bore, M. S. Velasco Del Castillo, A. Cacicedo Fernandez De Bobadilla, J. Onaindia Gandarias, M. Telleria Arrieta, G. Zugazabeitia Irazabal, O. Quintana Raczka, I. Rodriguez Sanchez, A. Romero Pereiro, E. Laraudogoitia Zaldumbide, I. Lekuona Goya, B. Bonello, E. El Louali, V. Fouilloux, I. Kammache, C. Ovaert, B. Kreitmann, A. Fraisse, R. Migliore, M. Adaniya, M. Barranco, G. Miramont, H. Tamagusuku, A. Alassar, R. Sharma, A. Marciniak, O. Valencia, N. Abdulkareem, M. Jahangiri, N. Jander, R. Kienzle, C. Gohlke-Baerwolf, H. Gohlke, F.-J. Neumann, J. Minners, S. Valbuena, F. De Torres, T. Lopez, J. J. Gomez, G. Guzman, F. Dominguez, E. Refoyo, M. Moreno, J. L. Lopez-Sendon, R. Ancona, S. Comenale Pinto, P. Caso, G. Di Salvo, S. Severino, M. Cavallaro, R. Calabro, R. Enache, R. Piazza, A. Roman-Pognuz, B. Popescu, A. Calin, C. Beladan, F. Purcarea, G. Nicolosi, C. Ginghina, O. Savu, M. Rosca, R. Jurcut, M. Serban, L. Dorobantu, E. Donal, S. Mascle, C. Thebault, D. Veillard, H. Hamonic, A. Leguerrier, H. Corbineau, B. A. Popa, M. Diena, A. Bogdan, D. Benea, G. Lanzillo, V. Casati, E. Novelli, A. Popa, G. Cerin, F. Gual Capllonch, A. Teis, J. Lopez Ayerbe, E. Ferrer, N. Vallejo, E. Gomez Denia, A. Bayes Genis, S. Spethmann, S. Schattke, G. Baldenhofer, V. Stangl, M. Laule, G. Baumann, K. Stangl, F. Knebel, C. Labata, C. Garcia Alonso, F. Gual, R. Nunez Aragon, C. Sousa, A. I. Vasile, M. Dorobantu, C. Iorgulescu, S. Bogdan, D. Constantinescu, C. Caldararu, O. Tautu, R. Vatasescu, H. Badran, M. F. Elnoamany, M. Ayad, A. Elshereef, A. Farhan, Y. Nassar, M. Yacoub, J. Costabel, G. Avegliano, P. Elissamburu, J. Thierer, F. Castro, M. Huguet, A. Frangi, R. Ronderos, C. Prinz, F. Van Buuren, L. Faber, T. Bitter, N. Bogunovic, W. Burchert, D. Horstkotte, J. D. Kasprzak, A. Smialowski, T. Rudzinski, P. Lipiec, M. Krzeminska-Pakula, K. Wierzbowska-Drabik, E. Trzos, M. Kurpesa, H. Motoki, M. Hana, T. Marwick, K. Allan, M. Vazquez-Alvarez, C. Medrano Lopez, S. Granja Da Silva, C. Marcos, A. Rodriguez-Ogando, M. Alvarez, M. Camino, M. Centeno, E. Maroto, G. Feltes Guzman, V. Serra Tomas, O. Acevedo, A. Calli, M. Barba, G. Pintos, V. Valverde, J. Zamorano Gomez, M. Marchel, J. Kochanowski, R. Piatkowski, A. Madej, K. Filipiak, I. Hausmanowa-Petrusewicz, G. Opolski, E. Malev, E. Zemtsovsky, S. Reeva, E. Timofeev, A. Pshepiy, S. Mihaila, R. Rimbas, R. Mincu, R. Dulgheru, R. Mihaila, C. Badiu, M. Cinteza, D. Vinereanu, E. Lira, D. Lebihan, C. Monaco, M. Ruiz Ortiz, D. Mesa, M. Delgado, E. Romo, M. Pena, M. Puentes, M. Santisteban, A. Lopez Granados, J. Arizon Del Prado, J. Suarez De Lezo, W.-C. Tsai, J.-Y. Shih, T.-S. Huang, Y.-W. Liu, Y.-Y. Huang, L.-M. Tsai, E. Cho, K. Choi, B. Kwon, D. Kim, S. Jang, C. Park, H. Jung, H. Jeon, H. Youn, J. Kim, A. E. Rieck, D. Cramariuc, M. Lonnebakken, B. Lund, P. Moceri, D. Doyen, P. Cerboni, E. Ferrari, W. Li, S. Goncalves, G. Vinhais De Sousa, A. G. Almeida, C. Hernandez Garcia, A. De La Rosa Hernandez, E. Arroyo Ucar, P. Jorge Perez, A. Barragan Acea, J. Lacalzada Almeida, J. Jimenez Rivera, A. Duque Garcia, I. Laynez Cerdena, O. Arhipov, A. N. Sumin, L. Campens, M. Renard, B. Trachet, P. Segers, A. De Paepe, J. De Backer, J. A. Purvis, D. Sharma, S. M. Hughes, D. Marek, D. Vindis, E. Kocianova, M. Taborsky, H. Yoon, K. Kim, Y. Ahn, M. Chung, J. Cho, J. Kang, W. Rha, O. Ozcan, D. Sezgin Ozcan, B. Candemir, M. Aras, I. Dincer, R. Atak, L. Gianturco, M. Turiel, F. Atzeni, L. Tomasoni, E. Bruschi, O. Epis, P. Sarzi-Puttini, C. Aggeli, E. Poulidakis, I. Felekos, S. Sideris, P. Dilaveris, K. Gatzoulis, C. Stefanadis, N. Roszczyk, M. Sobczak, J. Peruga, R. Krecki, J. Kasprzak, K. Ishii, T. Suyama, K. Kataoka, A. Furukawa, T. Nagai, M. Maenaka, Y. Seino, F. Musca, B. De Chiara, A. Moreo, S. Cataldo, M. Parolini, O. Parodi, T. Bombardini, F. Faita, S.-J. Park, J.-H. Kil, S.-J. Kim, S.-Y. Jang, S.-A. Chang, J.-O. Choi, S.-C. Lee, S. Park, P. Park, J. Oh, M. Cikes, V. Velagic, B. Biocina, H. Gasparovic, Z. Djuric, B. Bijnens, D. Milicic, A. Huqi, B. Klas, A. He, I. Paterson, M. Irween, J. Ezekovitz, J. Choy, Y. Chen, L. Cheng, R. Yao, H. Yao, H. Chen, C. Pan, X. Shu, B. Sobkowicz, M. Kaminska, W. Musial, R. Buechel, G. Sommer, G. Leibundgut, A. Rohner, J. Bremerich, B. Kaufmann, A. Kessel-Schaefer, M. Handke, A. Kiotsekoglou, S. Saha, R. Toole, S. Sharma, A. Gopal, S. Adhya, W. Tsang, C. Kenny, S. Kapetanakis, R. Lang, M. Monaghan, B. Smith, T. Coulter, A. Rendon, W.-S. Cheung, W. Gorissen, J. A. Ejlersen, O. May, F. J. Van Slochteren, T. Van Der Spoel, H. Hanssen, P. Doevendans, S. Chamuleau, C. De Korte, A. Tarr, S. Stoebe, T. Trache, J.-G. Kluge, A. Varga, A. Hagendorff, A. Nagy, A. Kovacs, A. Apor, B. Sax, D. Becker, B. Merkely, R. Lindquist, A. Miller, C. Reece, B. W. Eidem, W.-G. Choi, S. Kim, S. Oh, Y. Kim, R. Iacobelli, M. Chinali, M. D' Asaro, A. Toscano, A. Del Pasqua, C. Esposito, G. Seghetti, F. Parisi, G. Pongiglione, G. Rinelli, O. Omaygenc, R. Bakal, C. Dogan, K. Teber, S. Akpinar, G. Sahin, N. Ozdemir, A. Penhall, M. Joseph, F. Chong, C. De Pasquale, J. Selvanayagam, D. Leong, E. G. Nyktari, A. P. Patrianakos, C. Goudis, G. Solidakis, F. Parthenakis, P. Vardas, E. Nestaas, D. Fugelseth, A. Vitarelli, L. Capotosto, M. Bernardi, Y. Conde, F. Caranci, G. Placanica, O. Dettori, M. Vitarelli, S. De Chiara, V. De Cicco, M. Ferro', R. Calabro', S. Apostolakis, G. Chalikias, D. Tziakas, D. Stakos, A. Thomaidi, S. Konstantinides, G. Iorio, R. Rucos, G. Continanza, M. D Ascanio, L. Alessandroni, M. Saponara, M. Berry, J. Nahum, O. Zaghden, J. Monin, J. Couetil, O. Lairez, L. Macron, J. Dubois Rande, P. Gueret, P. Lim, M. Cameli, E. Giacomin, M. Lisi, S. Benincasa, F. Righini, D. Menci, M. Focardi, S. Mondillo, E. Philip, G. Gorincour, H. Bellsham-Revell, A. J. Bell, O. I. Miller, P. Beerbaum, R. Razavi, G. Greil, J. M. Simpson, S. Ann, T. Kim, J. Lee, J. Chin, P. Cabeza Lainez, V. Escolar Camas, L. Gheorghe, P. Fernandez Garcia, R. Vazquez Garcia, V. Caiulo, S. Caiulo, A. Fisicaro, F. Moramarco, G. Latini, A. Seale, J. Carvalho, H. Gardiner, M. Roughton, J. Simpson, A. Tometzki, O. Uzun, S. Webber, P. Daubeney, A. Dawood, G. Dwivedi, G. Mahadevan, D. Jiminez, R. Steeds, M. Frenneaux, C. H. Attenhofer Jost, B. Knechtle, A. Bernheim, M. Pfyffer, A. Linka, A. Faeh-Gunz, B. Seifert, G. De Pasquale, M. Zuber, A. Tomaszewski, A. Kutarski, and M. Tomaszewski more...
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Computer science ,Plane (geometry) ,business.industry ,Echo (computing) ,Left atrium ,General Medicine ,Biplane ,medicine.anatomical_structure ,Software ,Left atrial ,medicine ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine - Published
- 2011
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47. Mechanisms underlying the diabetes-induced hyporeactivity of the rabbit carotid artery to atrial natriuretic peptide
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I. Miranda, José M. Centeno, Teresa Jover-Mengual, Vannina G. Marrachelli, Juan B. Salom, Germán Torregrosa, Francisco J. Miranda, María Castelló-Ruiz, María C. Burguete, and Enrique Alborch
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Male ,medicine.medical_specialty ,Endothelium ,medicine.drug_class ,Thromboxane ,Down-Regulation ,Prostacyclin ,Vasodilation ,Diabetes Mellitus, Experimental ,Random Allocation ,Atrial natriuretic peptide ,Diabetes mellitus ,Internal medicine ,medicine ,Natriuretic peptide ,Animals ,Receptor ,Pharmacology ,business.industry ,medicine.disease ,Carotid Arteries ,medicine.anatomical_structure ,Endocrinology ,cardiovascular system ,Rabbits ,business ,Atrial Natriuretic Factor ,hormones, hormone substitutes, and hormone antagonists ,circulatory and respiratory physiology ,medicine.drug - Abstract
Atrial natriuretic peptide (ANP) plays an important role in the pathophysiology of the vascular complications in diabetes. The working hypothesis was that diabetes might modify the vascular actions of ANP in isolated rabbit carotid arteries and the mechanisms involved in these actions. ANP (10 −12 –10 −7 M) induced a relaxation of precontracted carotid arteries, which was lower in diabetic than in control rabbits. In arteries from both groups of animals, endothelium removal increased the ANP-induced relaxation. Isatin inhibited the relaxation to ANP both in arteries with and without endothelium. Carotid arteries from diabetic rabbits showed a decreased natriuretic peptide receptor (NPR)-A expression and an enhanced NPR-C expression. Inhibition of NO-synthesis did not modify ANP-induced relaxation in control rabbits but inhibited it in diabetic rabbits. In arteries with endothelium indomethacin enhanced the relaxation to ANP in control rabbits but did not modify it in diabetic rabbits. In endothelium-denuded arteries indomethacin inhibited the relaxation to ANP in both groups of animals. In KCl-depolarised arteries, relaxation to ANP was almost abolished both in control and diabetic rabbits. Tetraethylammonium inhibited the relaxation to ANP, and this inhibition was higher in diabetic than in control rabbits. These results suggest that diabetes produces hyporeactivity of the rabbit carotid artery to ANP by a mechanism that at least includes a reduced expression of NPR-A, an enhanced expression of NPR-C and a reduced participation of K + -channels. Furthermore, diabetes enhances endothelial NO release and diminishes the ratio thromboxane A 2 /prostacyclin. This increase of vasodilators could result from compensatory mechanisms counteracting the arterial hyporeactivity to ANP. more...
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- 2011
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48. Standardising the psychosocial assessment of oncological patients at Donostia university hospital
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Inês Delgado, M. Murguiondo, J. San Francisco, L. Moreno, G. Agirre, A. Barrio, L. Basterretxea, H. Telleria, M.J. Esnaola, M.A. Landa, E. Uranga, G. Jauregui, A. Valverde, M. Centeno, and O. Aizpurua more...
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medicine.medical_specialty ,Oncology ,business.industry ,Family medicine ,medicine ,Hematology ,business ,University hospital ,Psychosocial - Published
- 2018
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49. From Memories to Diaries: A Portrait of Hope Captured from the Lens of a Nurse Educator as a Breast Cancer Patient
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Praxedes S. M. de la Rosa, Lorenze Anthony A. Cheng, Dexter Jayrald S. Catambay, Jonathan Agustin R. Castro, Angelica M. Centeno, and Allan B. de Guzman
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Psychotherapist ,Psychoanalysis ,Subject (philosophy) ,Nurse educator ,medicine.disease ,Education ,Interpersonal relationship ,Breast cancer ,Portrait ,Embodied cognition ,medicine ,Meaning (existential) ,Geriatrics and Gerontology ,Psychology ,Period (music) - Abstract
Breast cancer is the most common malignancy affecting women worldwide. While it is true that hope influences how these victims view and live their lives, little is known as to how hope is lived and experienced by a breast cancer patient whose professional background and practice is nursing. This narrative–interpretive study purports to create a portrait of a nurse educator whose hope becomes her language of meaning-making. A Filipino nurse educator suffering from breast cancer was used as the subject of this study. Constituting the study's corpus of data is a series of diaries which were religiously written for a period of six months (November 2007–April 2008). Three interesting themes that elucidate the portrait of hope as embodied in the subject's diaries include (a) Stop: Searching for Meaning; (b) Look: Standing through Meaning; and (c) Listen: Sailing through Meaning. Notably, hope serving as a universal human experience is a powerful gift that enables an individual to see meaning amidst painful cond... more...
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- 2009
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50. The Relationship between the Outcome of Studies of Autologous Chondrocyte Implantation and the Presence of Commercial Funding
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James H. Lubowitz, Joseph M. Centeno, Shane K. Woolf, David Appleby, and John B. Reid
- Subjects
Cartilage, Articular ,medicine.medical_specialty ,Chirurgie orthopedique ,MEDLINE ,Physical Therapy, Sports Therapy and Rehabilitation ,English language ,Transplantation, Autologous ,03 medical and health sciences ,Chondrocytes ,0302 clinical medicine ,Research Support as Topic ,Internal medicine ,Outcome Assessment, Health Care ,medicine ,Humans ,Orthopedics and Sports Medicine ,Autologous chondrocyte implantation ,health care economics and organizations ,Publishing ,Clinical Trials as Topic ,Chi-Square Distribution ,Evidence-Based Medicine ,Conflict of Interest ,business.industry ,Outcome measures ,Treatment options ,030229 sport sciences ,Evidence-based medicine ,030220 oncology & carcinogenesis ,Meta-analysis ,Physical therapy ,business - Abstract
Background Autologous chondrocyte implantation (ACI) is an expensive treatment option for focal cartilage defects, and commercial funding of research is associated with a study reaching a positive conclusion. The purpose of this analysis is to compare outcomes (and levels of evidence) between published ACI outcome studies that were commercially funded and studies that were not commercially funded. Hypothesis Commercially funded ACI literature could be commercially biased. Study Design Comparative meta-analysis. Methods MEDLINE was searched for human, knee, ACI, nonmembrane, English language, and clinical outcome studies. Studies were evaluated with regard to funding status (commercially funded or not commercially funded), outcomes, and levels of evidence. Outcomes and levels of evidence were evaluated and compared for commercially funded studies versus those that were not commercially funded. Results Twenty-three studies were included; 16 (70%) were commercially funded. Pooled clinical outcome measures data were not significantly different (Lysholm, Modified Cincinnati, patient-reported Cincinnati, Tegner, pain Visual Analog Scale) when comparing commercially funded studies with those that were not commercially funded. However, distribution of levels of evidence was significantly lower (P = .045) for commercially funded studies. Conclusion Reassuringly, commercial funding of ACI studies did not result in a difference in published clinical outcomes versus those that were not commercially funded. However, the lower levels of evidence of commercially funded studies suggests that commercially funded ACI studies may be of less value to surgeons desiring to practice evidence-based medicine, and, in the future, commercial entities funding medical research could selectively fund studies of the highest levels of evidence. more...
- Published
- 2007
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