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1. Prospects for heavy neutral lepton searches at short and medium baseline reactor experiments

Author: N. van Remortel, M. Colomer Molla, B. Clerbaux, A. De Roeck, M. Drewes, R. Keloth, H. Sfar, S. Vercaemer, and M. Verstraeten
Subjects: Sterile or Heavy Neutrinos, Neutrino Mixing, Neutrino Interactions, Non-Standard Neutrino Properties, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Heavy neutrinos with masses in the MeV range can in principle simultaneously explain the light neutrino masses and the origin of baryonic matter in the universe. The strongest constraints on their properties come from their potential impact on the formation of light elements in the early universe. Since these constraints rely on assumptions about the cosmic history, independent checks in the laboratory are highly desirable. In this paper, we discuss the opportunity to search for heavy neutrinos within the MeV mass range in short and medium baseline reactor neutrino experiments, using the SoLid, JUNO and TAO experiments as examples. These experiments can give the currently strongest upper bound on the mixing between the light electron neutrinos and the heavy neutrino in the 2–9 MeV mass range.
Published: 2024
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2. Feebly-interacting particles: FIPs 2022 Workshop Report

Author: C. Antel, M. Battaglieri, J. Beacham, C. Boehm, O. Buchmüller, F. Calore, P. Carenza, B. Chauhan, P. Cladè, P. Coloma, P. Crivelli, V. Dandoy, L. Darmé, B. Dey, F. F. Deppisch, A. De Roeck, M. Drewes, B. Echenard, V. V. Flambaum, P. Foldenauer, C. Gatti, M. Giannotti, A. Golutvin, M. C. Gonzalez-Garcia, S. Gori, E. Goudzovski, A. Granelli, H. Grote, S. Guellati-Khelifa, J. Hajer, P. Harris, C. Hearty, D. Heuchel, M. Hostert, S. Junius, F. Kahlhoefer, J. Klaric, F. Kling, P. Klose, J. Knolle, J. Kopp, O. Kwon, O. Lantwin, G. Lanfranchi, L. Li, A. Lindner, J. Lopez-Pavon, J. Marocco, J. W. Martin, S. Middleton, S. Milstead, I. Oceano, C. A. J. O’Hare, A. Paoloni, S. Pascoli, S. T. Petcov, M. Pospelov, R. Pöttgen, M. Raggi, G. Ripellino, I. B. Samsonov, S. Sandner, S. Söldner-Rembold, J. Shelton, N. Song, C. Sun, Y. V. Stadnik, J.-L. Tastet, N. Toro, N. Tran, N. Trevisani, S. Ulmer, S. Urrea, B. Velghe, B. Wallisch, Y. Y. Y. Wong, C. Zorbilmez, and K. Zurek
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.
Published: 2023
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3. New benchmark models for heavy neutral lepton searches

Author: M. Drewes, J. Klarić, and J. López-Pavón
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The sensitivity of direct searches for heavy neutral leptons (HNLs) in accelerator-based experiments depends strongly on the particles properties. Commonly used benchmark scenarios are important to ensure comparability and consistency between experimental searches, re-interpretations, and sensitivity studies for different facilities. In models where the HNLs are primarily produced and decay through the weak interaction, benchmarks are in particular defined by fixing the relative strengths of their mixing with SM neutrinos of different flavours, and the interpretation of experimental data is known to strongly depend on those ratios. The commonly used benchmarks in which a single HNL flavour exclusively interacts with one Standard Model generation do not reflect what is found in realistic neutrino mass models. We identify two additional benchmarks for accelerator-based direct HNL searches, which we primarily select based on the requirement to provide a better approximation for the phenomenology of realistic neutrino mass models in view of present and future neutrino oscillation data.
Published: 2022
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4. Low-scale leptogenesis with flavour and CP symmetries

Author: M. Drewes, Y. Georis, C. Hagedorn, and J. Klarić
Subjects: Baryo-and Leptogenesis, Discrete Symmetries, Flavour Symmetries, Sterile or Heavy Neutrinos, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We consider a type-I seesaw framework endowed with a flavour symmetry, belonging to the series of non-abelian groups ∆(3 n 2) and ∆(6 n 2), and a CP symmetry. Breaking these symmetries in a non-trivial way results in the right-handed neutrinos being degenerate in mass up to possible (further symmetry-breaking) splittings κ and λ, while the neutrino Yukawa coupling matrix encodes the entire flavour structure in the neutrino sector. For a fixed combination of flavour and CP symmetry and residual groups, this matrix contains five real free parameters. Four of them are determined by the light neutrino mass spectrum and by accommodating experimental data on lepton mixing well, while the angle θ R is related to right-handed neutrinos. We scrutinise for all four lepton mixing patterns, grouped into Case 1) through Case 3 b.1), the potential to generate the baryon asymmetry of the Universe through low-scale leptogenesis numerically and analytically. The main results are: a) the possible correlation of the baryon asymmetry and the Majorana phases, encoded in the Pontecorvo-Maki-Nakagawa-Sakata mixing matrix, in certain instances; b) the possibility to generate the correct amount of baryon asymmetry for vanishing splittings κ and λ among the right-handed neutrinos as well as for large κ, depending on the case and the specific choice of group theory parameters; c) the chance to produce sufficient baryon asymmetry for large active-sterile mixing angles, enabling direct experimental tests at current and future facilities, if θ R is close to a special value, potentially protected by an enhanced residual symmetry. We elucidate these results with representative examples of flavour and CP symmetries, which all lead to a good agreement with the measured values of the lepton mixing angles and, possibly, the current indication of the CP phase δ. We identify the CP-violating combinations relevant for low-scale leptogenesis, and show that the parametric dependence of the baryon asymmetry found in the numerical study can be understood well with their help.
Published: 2022
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5. Feebly-interacting particles: FIPs 2020 workshop report

Author: P. Agrawal, M. Bauer, J. Beacham, A. Berlin, A. Boyarsky, S. Cebrian, X. Cid-Vidal, D. d’Enterria, A. De Roeck, M. Drewes, B. Echenard, M. Giannotti, G. F. Giudice, S. Gninenko, S. Gori, E. Goudzovski, J. Heeck, P. Hernandez, M. Hostert, I. G. Irastorza, A. Izmaylov, J. Jaeckel, F. Kahlhoefer, S. Knapen, G. Krnjaic, G. Lanfranchi, J. Monroe, V. I. Martinez Outschoorn, J. Lopez-Pavon, S. Pascoli, M. Pospelov, D. Redigolo, A. Ringwald, O. Ruchayskiy, J. Ruderman, H. Russell, J. Salfeld-Nebgen, P. Schuster, M. Shaposhnikov, L. Shchutska, J. Shelton, Y. Soreq, Y. Stadnik, J. Swallow, K. Tobioka, and Y.-D. Tsai
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract With the establishment and maturation of the experimental programs searching for new physics with sizeable couplings at the LHC, there is an increasing interest in the broader particle and astrophysics community for exploring the physics of light and feebly-interacting particles as a paradigm complementary to a New Physics sector at the TeV scale and beyond. FIPs 2020 has been the first workshop fully dedicated to the physics of feebly-interacting particles and was held virtually from 31 August to 4 September 2020. The workshop has gathered together experts from collider, beam dump, fixed target experiments, as well as from astrophysics, axions/ALPs searches, current/future neutrino experiments, and dark matter direct detection communities to discuss progress in experimental searches and underlying theory models for FIPs physics, and to enhance the cross-fertilisation across different fields. FIPs 2020 has been complemented by the topical workshop “Physics Beyond Colliders meets theory”, held at CERN from 7 June to 9 June 2020. This document presents the summary of the talks presented at the workshops and the outcome of the subsequent discussions held immediately after. It aims to provide a clear picture of this blooming field and proposes a few recommendations for the next round of experimental results.
Published: 2021
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6. Searches for long-lived particles at the future FCC-ee

Author: C. B. Verhaaren, J. Alimena, M. Bauer, P. Azzi, R. Ruiz, M. Neubert, O. Mikulenko, M. Ovchynnikov, M. Drewes, J. Klaric, A. Blondel, C. Rizzi, A. Sfyrla, T. Sharma, S. Kulkarni, A. Thamm, R. Gonzalez Suarez, and L. Rygaard
Subjects: future circular collider, particle physics, axion like particles, heavy neutral lepton, Higgs, Physics, QC1-999
Abstract: The electron-positron stage of the Future Circular Collider, FCC-ee, is a frontier factory for Higgs, top, electroweak, and flavour physics. It is designed to operate in a 100 km circular tunnel built at CERN, and will serve as the first step towards ≥100 TeV proton-proton collisions. In addition to an essential and unique Higgs program, it offers powerful opportunities to discover direct or indirect evidence of physics beyond the Standard Model. Direct searches for long-lived particles at FCC-ee could be particularly fertile in the high-luminosity Z run, where 5 × 1012Z bosons are anticipated to be produced for the configuration with two interaction points. The high statistics of Higgs bosons, W bosons and top quarks in very clean experimental conditions could offer additional opportunities at other collision energies. Three physics cases producing long-lived signatures at FCC-ee are highlighted and studied in this paper: heavy neutral leptons (HNLs), axion-like particles (ALPs), and exotic decays of the Higgs boson. These searches motivate out-of-the-box optimization of experimental conditions and analysis techniques, which could lead to improvements in other physics searches.
Published: 2022
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7. FCC Physics Opportunities

Author: A. Abada, M. Abbrescia, S. S. AbdusSalam, I. Abdyukhanov, J. Abelleira Fernandez, A. Abramov, M. Aburaia, A. O. Acar, P. R. Adzic, P. Agrawal, J. A. Aguilar-Saavedra, J. J. Aguilera-Verdugo, M. Aiba, I. Aichinger, G. Aielli, A. Akay, A. Akhundov, H. Aksakal, J. L. Albacete, S. Albergo, A. Alekou, M. Aleksa, R. Aleksan, R. M. Alemany Fernandez, Y. Alexahin, R. G. Alía, S. Alioli, N. Alipour Tehrani, B. C. Allanach, P. P. Allport, M. Altınlı, W. Altmannshofer, G. Ambrosio, D. Amorim, O. Amstutz, L. Anderlini, A. Andreazza, M. Andreini, A. Andriatis, C. Andris, A. Andronic, M. Angelucci, F. Antinori, S. A. Antipov, M. Antonelli, M. Antonello, P. Antonioli, S. Antusch, F. Anulli, L. Apolinário, G. Apollinari, A. Apollonio, D. Appelö, R. B. Appleby, Ara. Apyan, Arm. Apyan, A. Arbey, A. Arbuzov, G. Arduini, V. Arı, S. Arias, N. Armesto, R. Arnaldi, S. A. Arsenyev, M. Arzeo, S. Asai, E. Aslanides, R. W. Aßmann, D. Astapovych, M. Atanasov, S. Atieh, D. Attié, B. Auchmann, A. Audurier, S. Aull, S. Aumon, S. Aune, F. Avino, G. Avrillaud, G. Aydın, A. Azatov, G. Azuelos, P. Azzi, O. Azzolini, P. Azzurri, N. Bacchetta, E. Bacchiocchi, H. Bachacou, Y. W. Baek, V. Baglin, Y. Bai, S. Baird, M. J. Baker, M. J. Baldwin, A. H. Ball, A. Ballarino, S. Banerjee, D. P. Barber, D. Barducci, P. Barjhoux, D. Barna, G. G. Barnaföldi, M. J. Barnes, A. Barr, J. Barranco García, J. Barreiro Guimarães da Costa, W. Bartmann, V. Baryshevsky, E. Barzi, S. A. Bass, A. Bastianin, B. Baudouy, F. Bauer, M. Bauer, T. Baumgartner, I. Bautista-Guzmán, C. Bayındır, F. Beaudette, F. Bedeschi, M. Béguin, I. Bellafont, L. Bellagamba, N. Bellegarde, E. Belli, E. Bellingeri, F. Bellini, G. Bellomo, S. Belomestnykh, G. Bencivenni, M. Benedikt, G. Bernardi, J. Bernardi, C. Bernet, J. M. Bernhardt, C. Bernini, C. Berriaud, A. Bertarelli, S. Bertolucci, M. I. Besana, M. Besançon, O. Beznosov, P. Bhat, C. Bhat, M. E. Biagini, J.-L. Biarrotte, A. Bibet Chevalier, E. R. Bielert, M. Biglietti, G. M. Bilei, B. Bilki, C. Biscari, F. Bishara, O. R. Blanco-García, F. R. Blánquez, F. Blekman, A. Blondel, J. Blümlein, T. Boccali, R. Boels, S. A. Bogacz, A. Bogomyagkov, O. Boine-Frankenheim, M. J. Boland, S. Bologna, O. Bolukbasi, M. Bomben, S. Bondarenko, M. Bonvini, E. Boos, B. Bordini, F. Bordry, G. Borghello, L. Borgonovi, S. Borowka, D. Bortoletto, D. Boscherini, M. Boscolo, S. Boselli, R. R. Bosley, F. Bossu, C. Botta, L. Bottura, R. Boughezal, D. Boutin, G. Bovone, I. Božović Jelisavc̆ić, A. Bozbey, C. Bozzi, D. Bozzini, V. Braccini, S. Braibant-Giacomelli, J. Bramante, P. Braun-Munzinger, J. A. Briffa, D. Britzger, S. J. Brodsky, J. J. Brooke, R. Bruce, P. Brückman De Renstrom, E. Bruna, O. Brüning, O. Brunner, K. Brunner, P. Bruzzone, X. Buffat, E. Bulyak, F. Burkart, H. Burkhardt, J.-P. Burnet, F. Butin, D. Buttazzo, A. Butterworth, M. Caccia, Y. Cai, B. Caiffi, V. Cairo, O. Cakir, R. Calaga, S. Calatroni, G. Calderini, G. Calderola, A. Caliskan, D. Calvet, M. Calviani, J. M. Camalich, P. Camarri, M. Campanelli, T. Camporesi, A. C. Canbay, A. Canepa, E. Cantergiani, D. Cantore-Cavalli, M. Capeans, R. Cardarelli, U. Cardella, A. Cardini, C. M. Carloni Calame, F. Carra, S. Carra, A. Carvalho, S. Casalbuoni, J. Casas, M. Cascella, P. Castelnovo, G. Castorina, G. Catalano, V. Cavasinni, E. Cazzato, E. Cennini, A. Cerri, F. Cerutti, J. Cervantes, I. Chaikovska, J. Chakrabortty, M. Chala, M. Chamizo-Llatas, H. Chanal, D. Chanal, S. Chance, A. Chancé, P. Charitos, J. Charles, T. K. Charles, S. Chattopadhyay, R. Chehab, S. V. Chekanov, N. Chen, A. Chernoded, V. Chetvertkova, L. Chevalier, G. Chiarelli, G. Chiarello, M. Chiesa, P. Chiggiato, J. T. Childers, A. Chmielińska, A. Cholakian, P. Chomaz, M. Chorowski, W. Chou, M. Chrzaszcz, E. Chyhyrynets, G. Cibinetto, A. K. Ciftci, R. Ciftci, R. Cimino, M. Ciuchini, P. J. Clark, Y. Coadou, M. Cobal, A. Coccaro, J. Cogan, E. Cogneras, F. Collamati, C. Colldelram, P. Collier, J. Collot, R. Contino, F. Conventi, C. T. A. Cook, L. Cooley, G. Corcella, A. S. Cornell, G. H. Corral, H. Correia-Rodrigues, F. Costanza, P. Costa Pinto, F. Couderc, J. Coupard, N. Craig, I. Crespo Garrido, A. Crivellin, J. F. Croteau, M. Crouch, E. Cruz Alaniz, B. Curé, J. Curti, D. Curtin, M. Czech, C. Dachauer, R. T. D’Agnolo, M. Daibo, A. Dainese, B. Dalena, A. Daljevec, W. Dallapiazza, L. D’Aloia Schwartzentruber, M. Dam, G. D’Ambrosio, S. P. Das, S. DasBakshi, W. da Silva, G. G. da Silveira, V. D’Auria, S. D’Auria, A. David, T. Davidek, A. Deandrea, J. de Blas, C. J. Debono, S. De Curtis, N. De Filippis, D. de Florian, S. Deghaye, S. J. de Jong, C. Del Bo, V. Del Duca, D. Delikaris, F. Deliot, A. Dell’Acqua, L. Delle Rose, M. Delmastro, E. De Lucia, M. Demarteau, D. Denegri, L. Deniau, D. Denisov, H. Denizli, A. Denner, D. d’Enterria, G. de Rijk, A. De Roeck, F. Derue, O. Deschamps, S. Descotes-Genon, P. S. B. Dev, J. B. de Vivie de Régie, R. K. Dewanjee, A. Di Ciaccio, A. Di Cicco, B. M. Dillon, B. Di Micco, P. Di Nezza, S. Di Vita, A. Doblhammer, A. Dominjon, M. D’Onofrio, F. Dordei, A. Drago, P. Draper, Z. Drasal, M. Drewes, L. Duarte, I. Dubovyk, P. Duda, A. Dudarev, L. Dudko, D. Duellmann, M. Dünser, T. du Pree, M. Durante, H. Duran Yildiz, S. Dutta, F. Duval, J. M. Duval, Ya. Dydyshka, B. Dziewit, S. Eisenhardt, M. Eisterer, T. Ekelof, D. El Khechen, S. A. Ellis, J. Ellis, J. A. Ellison, K. Elsener, M. Elsing, Y. Enari, C. Englert, H. Eriksson, K. J. Eskola, L. S. Esposito, O. Etisken, E. Etzion, P. Fabbricatore, A. Falkowski, A. Falou, J. Faltova, J. Fan, L. Fanò, A. Farilla, R. Farinelli, S. Farinon, D. A. Faroughy, S. D. Fartoukh, A. Faus-Golfe, W. J. Fawcett, G. Felici, L. Felsberger, C. Ferdeghini, A. M. Fernandez Navarro, A. Fernández-Téllez, J. Ferradas Troitino, G. Ferrara, R. Ferrari, L. Ferreira, P. Ferreira da Silva, G. Ferrera, F. Ferro, M. Fiascaris, S. Fiorendi, C. Fiorio, O. Fischer, E. Fischer, W. Flieger, M. Florio, D. Fonnesu, E. Fontanesi, N. Foppiani, K. Foraz, D. Forkel-Wirth, S. Forte, M. Fouaidy, D. Fournier, T. Fowler, J. Fox, P. Francavilla, R. Franceschini, S. Franchino, E. Franco, A. Freitas, B. Fuks, K. Furukawa, S. V. Furuseth, E. Gabrielli, A. Gaddi, M. Galanti, E. Gallo, S. Ganjour, Jia. Gao, Jie. Gao, V. Garcia Diaz, M. García Pérez, L. García Tabarés, C. Garion, M. V. Garzelli, I. Garzia, S. M. Gascon-Shotkin, G. Gaudio, P. Gay, S.-F. Ge, T. Gehrmann, M. H. Genest, R. Gerard, F. Gerigk, H. Gerwig, P. Giacomelli, S. Giagu, E. Gianfelice-Wendt, F. Gianotti, F. Giffoni, S. S. Gilardoni, M. Gil Costa, M. Giovannetti, M. Giovannozzi, P. Giubellino, G. F. Giudice, A. Giunta, L. K. Gladilin, S. Glukhov, J. Gluza, G. Gobbi, B. Goddard, F. Goertz, T. Golling, D. Gonçalves, V. P. Goncalves, R. Gonçalo, L. A. Gonzalez Gomez, S. Gorgi Zadeh, G. Gorine, E. Gorini, S. A. Gourlay, L. Gouskos, F. Grancagnolo, A. Grassellino, A. Grau, E. Graverini, H. M. Gray, Ma. Greco, Mi. Greco, J.-L. Grenard, O. Grimm, C. Grojean, V. A. Gromov, J. F. Grosse-Oetringhaus, A. Grudiev, K. Grzanka, J. Gu, D. Guadagnoli, V. Guidi, S. Guiducci, G. Guillermo Canton, Y. O. Günaydin, R. Gupta, R. S. Gupta, J. Gutierrez, J. Gutleber, C. Guyot, V. Guzey, C. Gwenlan, Ch. Haberstroh, B. Hacışahinoğlu, B. Haerer, K. Hahn, T. Hahn, A. Hammad, C. Han, M. Hance, A. Hannah, P. C. Harris, C. Hati, S. Haug, J. Hauptman, V. Haurylavets, H-J. He, A. Hegglin, B. Hegner, K. Heinemann, S. Heinemeyer, C. Helsens, Ana. Henriques, And. Henriques, P. Hernandez, R. J. Hernández-Pinto, J. Hernandez-Sanchez, T. Herzig, I. Hiekkanen, W. Hillert, T. Hoehn, M. Hofer, W. Höfle, F. Holdener, S. Holleis, B. Holzer, D. K. Hong, C. G. Honorato, S. C. Hopkins, J. Hrdinka, F. Hug, B. Humann, H. Humer, T. Hurth, A. Hutton, G. Iacobucci, N. Ibarrola, L. Iconomidou-Fayard, K. Ilyina-Brunner, J. Incandela, A. Infantino, V. Ippolito, M. Ishino, R. Islam, H. Ita, A. Ivanovs, S. Iwamoto, A. Iyer, S. Izquierdo Bermudez, S. Jadach, D. O. Jamin, P. Janot, P. Jarry, A. Jeff, P. Jenny, E. Jensen, M. Jensen, X. Jiang, J. M. Jiménez, M. A. Jones, O. R. Jones, J. M. Jowett, S. Jung, W. Kaabi, M. Kado, K. Kahle, L. Kalinovskaya, J. Kalinowski, J. F. Kamenik, K. Kannike, S. O. Kara, H. Karadeniz, V. Karaventzas, I. Karpov, S. Kartal, A. Karyukhin, V. Kashikhin, J. Katharina Behr, U. Kaya, J. Keintzel, P. A. Keinz, K. Keppel, R. Kersevan, K. Kershaw, H. Khanpour, S. Khatibi, M. Khatiri Yanehsari, V. V. Khoze, J. Kieseler, A. Kilic, A. Kilpinen, Y.-K. Kim, D. W. Kim, U. Klein, M. Klein, F. Kling, N. Klinkenberg, S. Klöppel, M. Klute, V. I. Klyukhin, M. Knecht, B. Kniehl, F. Kocak, C. Koeberl, A. M. Kolano, A. Kollegger, K. Kołodziej, A. A. Kolomiets, J. Komppula, I. Koop, P. Koppenburg, M. Koratzinos, M. Kordiaczyńska, M. Korjik, O. Kortner, P. Kostka, W. Kotlarski, C. Kotnig, T. Köttig, A. V. Kotwal, A. D. Kovalenko, S. Kowalski, J. Kozaczuk, G. A. Kozlov, S. S. Kozub, A. M. Krainer, T. Kramer, M. Krämer, M. Krammer, A. A. Krasnov, F. Krauss, K. Kravalis, L. Kretzschmar, R. M. Kriske, H. Kritscher, P. Krkotic, H. Kroha, M. Kucharczyk, S. Kuday, A. Kuendig, G. Kuhlmann, A. Kulesza, Mi. Kumar, Mu. Kumar, A. Kusina, S. Kuttimalai, M. Kuze, T. Kwon, F. Lackner, M. Lackner, E. La Francesca, M. Laine, G. Lamanna, S. La Mendola, E. Lançon, G. Landsberg, P. Langacker, C. Lange, A. Langner, A. J. Lankford, J. P. Lansberg, T. Lari, P. J. Laycock, P. Lebrun, A. Lechner, K. Lee, S. Lee, R. Lee, T. Lefevre, P. Le Guen, T. Lehtinen, S. B. Leith, P. Lenzi, E. Leogrande, C. Leonidopoulos, I. Leon-Monzon, G. Lerner, O. Leroy, T. Lesiak, P. Lévai, A. Leveratto, E. Levichev, G. Li, S. Li, R. Li, D. Liberati, M. Liepe, D. A. Lissauer, Z. Liu, A. Lobko, E. Locci, E. Logothetis Agaliotis, M. P. Lombardo, A. J. Long, C. Lorin, R. Losito, A. Louzguiti, I. Low, D. Lucchesi, M. T. Lucchini, A. Luciani, M. Lueckhof, A. J. G. Lunt, M. Luzum, D. A. Lyubimtsev, M. Maggiora, N. Magnin, M. A. Mahmoud, F. Mahmoudi, J. Maitre, V. Makarenko, A. Malagoli, J. Malclés, L. Malgeri, P. J. Mallon, F. Maltoni, S. Malvezzi, O. B. Malyshev, G. Mancinelli, P. Mandrik, P. Manfrinetti, M. Mangano, P. Manil, M. Mannelli, G. Marchiori, F. Marhauser, V. Mariani, V. Marinozzi, S. Mariotto, P. Marquard, C. Marquet, T. Marriott-Dodington, R. Martin, O. Martin, J. Martin Camalich, T. Martinez, H. Martinez Bruzual, M. I. Martínez-Hernández, D. E. Martins, S. Marzani, D. Marzocca, L. Marzola, S. Masciocchi, I. Masina, A. Massimiliano, A. Massironi, T. Masubuchi, V. A. Matveev, M. A. Mazzoni, M. McCullough, P. A. McIntosh, P. Meade, L. Medina, A. Meier, J. Meignan, B. Mele, J. G. Mendes Saraiva, F. Menez, M. Mentink, E. Meoni, P. Meridiani, M. Merk, P. Mermod, V. Mertens, L. Mether, E. Métral, M. Migliorati, A. Milanese, C. Milardi, G. Milhano, B. L. Militsyn, F. Millet, I. Minashvili, J. V. Minervini, L. S. Miralles, D. Mirarchi, S. Mishima, D. P. Missiaen, G. Mitselmakher, T. Mitsuhashi, J. Mnich, M. Mohammadi Najafabadi, R. N. Mohapatra, N. Mokhov, J. G. Molson, R. Monge, C. Montag, G. Montagna, S. Monteil, G. Montenero, E. Montesinos, F. Moortgat, N. Morange, G. Morello, M. Moreno Llácer, M. Moretti, S. Moretti, A. K. Morley, A. Moros, I. Morozov, V. Morretta, M. Morrone, A. Mostacci, S. Muanza, N. Muchnoi, M. Mühlegger, M. Mulder, M. Mulders, B. Müller, F. Müller, A.-S. Müller, J. Munilla, M. J. Murray, Y. Muttoni, S. Myers, M. Mylona, J. Nachtman, T. Nakamoto, M. Nardecchia, G. Nardini, P. Nason, Z. Nergiz, A. V. Nesterenko, A. Nettsträter, C. Neubüser, J. Neundorf, F. Niccoli, O. Nicrosini, Y. Nie, U. Niedermayer, J. Niedziela, A. Niemi, S. A. Nikitin, A. Nisati, J. M. No, M. Nonis, Y. Nosochkov, M. Novák, A. Novokhatski, J. M. O’Callaghan, C. Ochando, S. Ogur, K. Ohmi, K. Oide, V. A. Okorokov, Y. Okumura, C. Oleari, F. I. Olness, Y. Onel, M. Ortino, J. Osborne, P. Osland, T. Otto, K. Y. Oyulmaz, A. Ozansoy, V. Özcan, K. Özdemir, C. E. Pagliarone, H. F. Pais da Silva, E. Palmieri, L. Palumbo, A. Pampaloni, R.-Q. Pan, M. Panareo, O. Panella, G. Panico, G. Panizzo, A. A. Pankov, V. Pantsyrny, C. G. Papadopoulos, A. Papaefstathiou, Y. Papaphilippou, M. A. Parker, V. Parma, M. Pasquali, S. K. Patra, R. Patterson, H. Paukkunen, F. Pauss, S. Peggs, J.-P. Penttinen, G. Peón, E. E. Perepelkin, E. Perez, J. C. Perez, G. Perez, F. Pérez, E. Perez Codina, J. Perez Morales, M. Perfilov, H. Pernegger, M. Peruzzi, C. Pes, K. Peters, S. Petracca, F. Petriello, L. Pezzotti, S. Pfeiffer, F. Piccinini, T. Pieloni, M. Pierini, H. Pikhartova, G. Pikurs, E. Pilicer, P. Piminov, C. Pira, R. Pittau, W. Płaczek, M. Plagge, T. Plehn, M.-A. Pleier, M. Płoskoń, M. Podeur, H. Podlech, T. Podzorny, L. Poggioli, A. Poiron, G. Polesello, M. Poli Lener, A. Polini, J. Polinski, S. M. Polozov, L. Ponce, M. Pont, L. Pontecorvo, T. Portaluri, K. Potamianos, C. Prasse, M. Prausa, A. Preinerstorfer, E. Premat, T. Price, M. Primavera, F. Prino, M. Prioli, J. Proudfoot, A. Provino, T. Pugnat, N. Pukhaeva, S. Puławski, D. Pulikowski, G. Punzi, M. Putti, A. Pyarelal, H. Quack, M. Quispe, A. Racioppi, H. Rafique, V. Raginel, M. Raidal, N. S. Ramírez-Uribe, M. J. Ramsey-Musolf, R. Rata, P. Ratoff, F. Ravotti, P. Rebello Teles, M. Reboud, S. Redaelli, E. Renner, A. E. Rentería-Olivo, M. Rescigno, J. Reuter, A. Ribon, A. M. Ricci, W. Riegler, S. Riemann, B. Riemann, T. Riemann, J. M. Rifflet, R. A. Rimmer, R. Rinaldesi, L. Rinolfi, O. Rios Rubiras, T. Risselada, A. Rivetti, L. Rivkin, T. Rizzo, T. Robens, F. Robert, A. J. Robson, E. Rochepault, C. Roda, G. Rodrigo, M. Rodríguez-Cahuantzi, C. Rogan, M. Roig, S. Rojas-Torres, J. Rojo, G. Rolandi, G. Rolando, P. Roloff, A. Romanenko, A. Romanov, F. Roncarolo, A. Rosado Sanchez, G. Rosaz, L. Rossi, A. Rossi, R. Rossmanith, B. Rousset, C. Royon, X. Ruan, I. Ruehl, V. Ruhlmann-Kleider, R. Ruiz, L. Rumyantsev, R. Ruprecht, A. I. Ryazanov, A. Saba, R. Sadykov, D. Saez de Jauregui, M. Sahin, B. Sailer, M. Saito, F. Sala, G. P. Salam, J. Salfeld-Nebgen, C. A. Salgado, S. Salini, J. M. Sallese, T. Salmi, A. Salzburger, O. A. Sampayo, S. Sanfilippo, J. Santiago, E. Santopinto, R. Santoro, A. Sanz Ull, X. Sarasola, I. H. Sarpün, M. Sauvain, S. Savelyeva, R. Sawada, G. F. R. Sborlini, A. Schaffer, M. Schaumann, M. Schenk, C. Scheuerlein, I. Schienbein, K. Schlenga, H. Schmickler, R. Schmidt, D. Schoerling, A. Schoning, T. Schörner-Sadenius, M. Schott, D. Schulte, P. Schwaller, C. Schwanenberger, P. Schwemling, N. Schwerg, L. Scibile, A. Sciuto, E. Scomparin, C. Sebastiani, B. Seeber, M. Segreti, P. Selva, M. Selvaggi, C. Senatore, A. Senol, L. Serin, M. Serluca, N. Serra, A. Seryi, L. Sestini, A. Sfyrla, M. Shaposhnikov, E. Shaposhnikova, B. Yu. Sharkov, D. Shatilov, J. Shelton, V. Shiltsev, I. P. Shipsey, G. D. Shirkov, A. Shivaji, D. Shwartz, T. Sian, S. Sidorov, A. Siemko, L. Silvestrini, N. Simand, F. Simon, B. K. Singh, A. Siódmok, Y. Sirois, E. Sirtori, R. Sirvinskaite, B. Sitar, T. Sjöstrand, P. Skands, E. Skordis, K. Skovpen, M. Skrzypek, E. Slade, P. Slavich, R. Slovak, V. Smaluk, V. Smirnov, W. Snoeys, L. Soffi, P. Sollander, O. Solovyanov, H. K. Soltveit, H. Song, P. Sopicki, M. Sorbi, L. Spallino, M. Spannowsky, B. Spataro, P. Sphicas, H. Spiesberger, P. Spiller, M. Spira, T. Srivastava, J. Stachel, A. Stakia, J. L. Stanyard, E. Starchenko, A. Yu. Starikov, A. M. Staśto, M. Statera, R. Steerenberg, J. Steggemann, A. Stenvall, F. Stivanello, D. Stöckinger, L. S. Stoel, M. Stöger-Pollach, B. Strauss, M. Stuart, G. Stupakov, S. Su, A. Sublet, K. Sugita, L. Sulak, M. K. Sullivan, S. Sultansoy, T. Sumida, K. Suzuki, G. Sylva, M. J. Syphers, A. Sznajder, M. Taborelli, N. A. Tahir, E. Tal Hod, M. Takeuchi, C. Tambasco, J. Tanaka, K. Tang, I. Tapan, S. Taroni, G. F. Tartarelli, G. Tassielli, L. Tavian, T. M. Taylor, G. N. Taylor, A. M. Teixeira, G. Tejeda-Muñoz, V. I. Telnov, R. Tenchini, H. H. J. ten Kate, K. Terashi, A. Tesi, M. Testa, C. Tetrel, D. Teytelman, J. Thaler, A. Thamm, S. Thomas, M. T. Tiirakari, V. Tikhomirov, D. Tikhonov, H. Timko, V. Tisserand, L. M. Tkachenko, J. Tkaczuk, J. Ph. Tock, B. Todd, E. Todesco, R. Tomás Garcia, D. Tommasini, G. Tonelli, F. Toral, T. Torims, R. Torre, Z. Townsend, R. Trant, D. Treille, L. Trentadue, A. Tricoli, A. Tricomi, W. Trischuk, I. S. Tropin, B. Tuchming, A. A. Tudora, B. Turbiarz, I. Turk Cakir, M. Turri, T. Tydecks, J. Usovitsch, J. Uythoven, R. Vaglio, A. Valassi, F. Valchkova, M. A. Valdivia Garcia, P. Valente, R. U. Valente, A.-M. Valente-Feliciano, G. Valentino, L. Vale Silva, J. M. Valet, R. Valizadeh, J. W. F. Valle, S. Vallecorsa, G. Vallone, M. van Leeuwen, U. H. van Rienen, L. van Riesen-Haupt, M. Varasteh, L. Vecchi, P. Vedrine, G. Velev, R. Veness, A. Ventura, W. Venturini Delsolaro, M. Verducci, C. B. Verhaaren, C. Vernieri, A. P. Verweij, O. Verwilligen, O. Viazlo, A. Vicini, G. Viehhauser, N. Vignaroli, M. Vignolo, A. Vitrano, I. Vivarelli, S. Vlachos, M. Vogel, D. M. Vogt, V. Völkl, P. Volkov, G. Volpini, J. von Ahnen, G. Vorotnikov, G. G. Voutsinas, V. Vysotsky, U. Wagner, R. Wallny, L.-T. Wang, R. Wang, K. Wang, B. F. L. Ward, T. P. Watson, N. K. Watson, Z. Wa̧s, C. Weiland, S. Weinzierl, C. P. Welsch, J. Wenninger, M. Widorski, U. A. Wiedemann, H.-U. Wienands, G. Wilkinson, P. H. Williams, A. Winter, A. Wohlfahrt, T. Wojtoń, D. Wollmann, J. Womersley, D. Woog, X. Wu, A. Wulzer, M. K. Yanehsari, G. Yang, H. J. Yang, W.-M. Yao, E. Yazgan, V. Yermolchik, Ay. Yilmaz, Al. Yilmaz, H.-D. Yoo, S. A. Yost, T. You, C. Young, T.-T. Yu, F. Yu, A. Zaborowska, S. G. Zadeh, M. Zahnd, M. Zanetti, L. Zanotto, L. Zawiejski, P. Zeiler, M. Zerlauth, S. M. Zernov, G. Zevi Dell Porta, Z. Zhang, Y. Zhang, C. Zhang, H. Zhang, Z. Zhao, Y.-M. Zhong, J. Zhou, D. Zhou, P. Zhuang, G. Zick, F. Zimmermann, J. Zinn-Justin, L. Zivkovic, A. V. Zlobin, M. Zobov, J. Zupan, J. Zurita, and The FCC Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
Published: 2019
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8. Pain Sensitivity and Psychiatric Comorbidities in Chronic Pancreatitis Patients With and Without Pain: Past Experience Matters

Author: Anna E. Phillips, Benjamin L. Bick, Mahya Faghih, Dhiraj Yadav, Asbjørn M. Drewes, Vikesh K. Singh, and Søren S. Olesen
Subjects: Chronic Pancreatitis, Pain, Psychiatric Comorbidities, Hyperalgesia, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Background and Aims: Pain is the primary symptom of chronic pancreatitis (CP) and has been associated with abnormal pain processing and psychologic distress. Little is known about these phenomena in patients with painless disease. The aim of this study was to characterize patterns of pain processing and psychologic distress in patients with primary painless vs painful CP. Methods: This was a cross-sectional multicenter study of 235 patients with definitive CP. Patients were categorized based on current and past pain history; current pain (79%), no current (but prior) pain (11%), and painless CP (10%). Demographic information and clinical data including symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale were collected. All patients underwent quantitative sensory testing to assess patterns of pain processing. Results: A total of 235 patients (57% males, mean age 53.9 ± 14.0 years, 41% alcohol etiology) were included. Compared to patients with painless CP, enhanced pain sensitivity was observed in both patients with current pain (odds ratio [OR] 3.29; 95% confidence interval [CI] [1.11–9.77], P = .032) and no current pain (OR 4.07; 95% CI [1.10–15.03], P = .035). Patients with current pain also had increased depression prevalence compared to patients with painless CP (OR 6.15; 95% CI [1.28–29.41], P = .023), while no difference was seen for patients with no current pain (OR 1.24; 95% CI [0.19–8.26], P = .824). Conclusion: Total absence of pain in CP is associated with normal pain processing and low prevalence of psychologic distress, whereas patients with prior pain experience appear to have persistent and enhanced pain sensitivity even in the absence of clinical pain and psychologic distress.
Published: 2022
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9. Combined extracorporeal shock wave lithotripsy and endoscopic treatment for pain in chronic pancreatitis (SCHOKE trial): study protocol for a randomized, sham-controlled trial

Author: Søren S. Olesen, Asbjørn M. Drewes, Rajesh Gaud, Manu Tandan, Sundeep Lakhtakia, Mohan Ramchandani, G. V. Rao, D. Nageshwar Reddy, and Rupjyoti Talukdar
Subjects: Medicine (General), R5-920
Abstract: Abstract Background Pain is the primary symptom of chronic pancreatitis (CP) and remains a considerable therapeutic challenge. In patients with obstruction of the pancreatic duct, including stones and strictures, endoscopic treatment with or without preceding extracorporeal shock wave lithotripsy (ESWL) has been used for pancreatic duct decompression. The rationale for these procedures is based on the assumption that obstruction of the pancreatic duct leads to ductal hypertension and pain. However, clinical pain symptoms correlate poorly with pancreatic duct morphology, and the evidence for pancreatic duct decompression as an effective treatment for pain is based on case series and comparison between different procedures. No randomized, prospective, sham-controlled trials are currently available. The SCHOKE (Extracorporeal Shock Wave Lithotripsy and Endotherapy for Pain in Chronic Pancreatitis) trial is a randomized, sham-controlled trial designed to determine if pancreatic duct decompression is an effective treatment for pain in patients with CP. Methods The SCHOKE trial is a randomized, single-blind, parallel-group, sham-controlled trial designed to evaluate the effect of combined ESWL and endoscopic treatment for pain in patients with CP. In total, 106 adult patients with painful CP and pancreatic duct obstruction will be randomized to combined ESWL and subsequent endoscopic treatment or corresponding sham procedures. The primary outcome is pain relief during the 3-month postrandomization period as documented in a pain diary. Secondary outcomes include quality of life and functional scores, patient global impression of change, change in use of analgesics, frequency of hospitalization, and complications. Standard follow-up is at 3 and 6 months after randomization. In an experimental substudy, quantitative sensory testing obtained before and after intervention will be used to obtain information on central pain processing and to develop models for prediction of treatment outcome. Discussion The SCHOKE trial investigates if pancreatic duct decompression, obtained by combined ESWL and endoscopic treatment, is effective for pain treatment in patients with CP. Trial registration ClinicalTrials.gov , NCT03966781 . Registered on May 25, 2019. Protocol date and version identifier: March 1, 2020; version 3.0. Sponsor: Rupjyoti Talukdar, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Published: 2020
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10. Risk of primary brain tumour after breast cancer

Author: Anne M Drewes, Maria E Møller, Rasmus Hertzum-Larsen, Gerda Engholm, and Hans H Storm
Subjects: breast cancer, brain tumour, oestrogen, progesterone, nordcan, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction: Cancer registry data in the USA indicated that women diagnosed with breast cancer before the age of 40 were at increased risk of a new primary tumour within the brain and women aged 50 years or above were at lower risk than expected. Our aim was to investigate if similar results could be found in Danish population-based data, considering an explanatory role of hormonal status. Methods: Our study cohort included all women diagnosed with breast cancer below the age of 60 between 1978 and 2013 in Denmark. A total of 47,920 women were followed up in the Danish Cancer Registry for primary brain cancer. Standardized incidence ratios (observed/expected cases (O/E)) were used to estimate the risk of getting a primary brain tumour in the breast cancer cohort. Results: Data indicated an increased tendency of brain cancer following breast cancer at ages below 60 years (O/E = 1.24). For premenopausal women (age
Published: 2020
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11. Cardiovascular risk factors and major recurrent coronary events: A genetic liability study in patients with coronary artery disease in the UK Biobank

Author: Raymond Noordam, Thomas AG. Brochard, Yvonne M. Drewes, Jacobijn Gussekloo, Simon P. Mooijaart, Ko Willems van Dijk, Stella Trompet, J. Wouter Jukema, and Diana van Heemst
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

12. Geriatric rehabilitation care after hip fracture

Author: G. F. Mattiazzo, Y. M. Drewes, M. van Eijk, and W. P. Achterberg
Subjects: General Medicine
Abstract: Purpose After acute hospital admission, patients with a hip fracture are frequently discharged to skilled nursing homes providing geriatric rehabilitation (GR). There are few evidence-based studies regarding specific treatment times and assessments during GR. This study aims to provide a description of care for hip fracture patients during GR in the Netherlands. Methods Descriptive study analyzing the care pathways from GR facilities, regarding healthcare professionals involved, allocated treatment time per profession, total length of rehabilitation stay, and assessment instruments. Based on the reimbursement algorithm (diagnostic treatment combination = DBCs), of 25 patients, the registered actual treatment time per profession was calculated. Results The care pathways pivoted on three groups of health care professionals: medical team (MT), physiotherapy (PT), and occupational therapy (OT). There was some discrepancy between the allocated time in the care pathways and the calculated mean actual treatment time from the DBCs. First week: MT 120–180 min, DBC 120 (SD: 59) minutes; PT 120–230 min, DBC 129 (SD: 58) minutes; and OT 65–165 min, DBC 93 (SD: 61) minutes. From week two onwards, MT 15–36 min, DBC 49 (SD: 29) minutes; PT 74–179 min, DBC 125 (SD: 50) minutes; and OT 25–60 min, DBC 47 (SD: 44) minutes. Dieticians, psychologists, and social workers were sporadically mentioned. There was heterogeneity in the assessment and screening tools. Conclusions It is difficult to define current standard care in GR after hip fracture in the Netherlands due to the diversity in care pathways and large practice variation. This is a problem in conducting randomized effectiveness research with care provided as control. Trial register and date of registration NL7491 04-02-2019.
Published: 2023

13. Deprescribing preventive cardiovascular medication in patients with predicted low cardiovascular disease risk in general practice – the ECSTATIC study: a cluster randomised non-inferiority trial

Author: Clare H. Luymes, Rosalinde K. E. Poortvliet, Nan van Geloven, Margot W. M. de Waal, Yvonne M. Drewes, Jeanet W. Blom, Nynke Smidt, Willem J. J. Assendelft, Wilbert B. van den Hout, Wouter de Ruijter, and Mattijs E. Numans
Subjects: General practice, Preventive medicine, Cardiovascular disease, Antihypertensive agent, Anticholesteremic agent, Inappropriate prescribing, Medicine
Abstract: Abstract Background The use of cardiovascular medication for the primary prevention of cardiovascular disease (CVD) is potentially inappropriate when potential risks outweigh the potential benefits. It is unknown whether deprescribing preventive cardiovascular medication in patients without a strict indication for such medication is safe and cost-effective in general practice. Methods In this pragmatic cluster randomised controlled non-inferiority trial, we recruited 46 general practices in the Netherlands. Patients aged 40–70 years who were using antihypertensive and/or lipid-lowering drugs without CVD and with low risk of future CVD were followed for 2 years. The intervention was an attempt to deprescribe preventive cardiovascular medication. The primary outcome was the difference in the increase in predicted (10-year) CVD risk in the per-protocol (PP) population with a non-inferiority margin of 2.5 percentage points. An economic evaluation was performed in the intention-to-treat (ITT) population. We used multilevel (generalised) linear regression with multiple imputation of missing data. Results Of 1067 participants recruited between 7 November 2012 and 18 February 2014, 72% were female. Overall, their mean age was 55 years and their mean predicted CVD risk at baseline was 5%. Of 492 participants in the ITT intervention group, 319 (65%) quit the medication (PP intervention group); 135 (27%) of those participants were still not taking medication after 2 years. The predicted CVD risk increased by 2.0 percentage points in the PP intervention group compared to 1.9 percentage points in the usual care group. The difference of 0.1 (95% CI -0.3 to 0.6) fell within the non-inferiority margin. After 2 years, compared to the usual care group, for the PP intervention group, systolic blood pressure was 6 mmHg higher, diastolic blood pressure was 4 mmHg higher and total cholesterol and low-density lipoprotein-cholesterol levels were both 7 mg/dl higher (all P
Published: 2018
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14. Pain chronification impacts whole-brain functional connectivity in women with hip osteoarthritis during pain stimulation

Author: Joachim Erlenwein, Anne Kästner, Mikkel Gram, Deborah Falla, Asbjørn M Drewes, Michael Przemeck, and Frank Petzke
Subjects: Anesthesiology and Pain Medicine, Neurology (clinical), General Medicine
Abstract: ObjectivePrevious neuroimaging studies have shown that patients with chronic pain display altered functional connectivity across distributed brain areas involved in the processing of nociceptive stimuli. The aim of the present study was to investigate how pain chronification modulates whole-brain functional connectivity during evoked clinical and tonic pain.MethodsPatients with osteoarthritis of the hip (n = 87) were classified into 3 stages of pain chronification (Grades I–III, Mainz Pain Staging System). Electroencephalograms were recorded during 3 conditions: baseline, evoked clinical hip pain, and tonic cold pain (cold pressor test). The effects of both factors (recording condition and pain chronification stage) on the phase-lag index, as a measure of neuronal connectivity, were examined for different frequency bands.ResultsIn women, we found increasing functional connectivity in the low-frequency range (delta, 0.5–4 Hz) across pain chronification stages during evoked clinical hip pain and tonic cold pain stimulation. In men, elevated functional connectivity in the delta frequency range was observed in only the tonic cold pain condition.ConclusionsAcross pain chronification stages, we found that widespread cortical networks increase their synchronization of delta oscillations in response to clinical and experimental nociceptive stimuli. In view of previous studies relating delta oscillations to salience detection and other basic motivational processes, our results hint at these mechanisms playing an important role in pain chronification, mainly in women. ObjectivePrevious neuroimaging studies have shown that patients with chronic pain display altered functional connectivity across distributed brain areas involved in the processing of nociceptive stimuli. The aim of the present study was to investigate how pain chronification modulates whole-brain functional connectivity during evoked clinical and tonic pain.MethodsPatients with osteoarthritis of the hip (n = 87) were classified into 3 stages of pain chronification (Grades I–III, Mainz Pain Staging System). Electroencephalograms were recorded during 3 conditions: baseline, evoked clinical hip pain, and tonic cold pain (cold pressor test). The effects of both factors (recording condition and pain chronification stage) on the phase-lag index, as a measure of neuronal connectivity, were examined for different frequency bands.ResultsIn women, we found increasing functional connectivity in the low-frequency range (delta, 0.5–4 Hz) across pain chronification stages during evoked clinical hip pain and tonic cold pain stimulation. In men, elevated functional connectivity in the delta frequency range was observed in only the tonic cold pain condition.ConclusionsAcross pain chronification stages, we found that widespread cortical networks increase their synchronization of delta oscillations in response to clinical and experimental nociceptive stimuli. In view of previous studies relating delta oscillations to salience detection and other basic motivational processes, our results hint at these mechanisms playing an important role in pain chronification, mainly in women.
Published: 2023

15. Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis:study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial)

Author: Mathias E. Cook, Cecilie S. Knoph, Camilla A. Fjelsted, Jens B. Frøkjær, Anders E. Bilgrau, Srdan Novovic, Maiken Thyregod Jørgensen, Michael B. Mortensen, Liv B. J. Nielsen, Amer Hadi, Mark Berner-Hansen, Wiktor Rutkowski, Miroslav Vujasinovic, Matthias Löhr, Asbjørn M. Drewes, and Søren S. Olesen
Subjects: Peripherally acting µ-opioid receptor antagonist, Analgesics, Opioid/adverse effects, Narcotic Antagonists/adverse effects, Naldemedine, Medicine (miscellaneous), Opioid, Recurrent acute pancreatitis, Pancreatitis, Chronic/drug therapy, Treatment Outcome, Magnetic resonance imaging, Double-Blind Method, Randomized controlled trial, Acute Disease, Disease Progression, Quality of Life, Humans, Pharmacology (medical), Randomized Controlled Trials as Topic
Abstract: BackgroundAcute and chronic pancreatitis constitute a continuum of inflammatory disease of the pancreas with an increasing incidence in most high-income countries. A subset of patients with a history of pancreatitis suffer from recurrence of acute pancreatitis attacks, which accelerate disease progression towards end-stage chronic pancreatitis with loss of exocrine and endocrine function. There is currently no available prophylactic treatment for recurrent acute pancreatitis apart from removing risk factors, which is not always possible. Pain is the primary symptom of acute pancreatitis, which induces the endogenous release of opioids. This may further be potentiated by opioid administration for pain management. Increased exposure to opioids leads to potentially harmful effects on the gastrointestinal tract, including, e.g. increased sphincter tones and decreased fluid secretion, which may impair pancreatic ductal clearance and elevate the risk for new pancreatitis attacks and accelerate disease progression. Peripherally acting µ-opioid receptor antagonists (PAMORAs) have been developed to counteract the adverse effects of opioids on the gastrointestinal tract. We hypothesize that the PAMORA naldemedine will reduce the risk of new pancreatitis attacks in patients with recurrent acute pancreatitis and hence decelerate disease progression.MethodsThe study is a double-blind, randomized controlled trial with allocation of patients to either 0.2 mg naldemedine daily or matching placebo for 12 months. A total of 120 outpatients will be enrolled from five specialist centres in Denmark and Sweden. The main inclusion criteria is a history of recurrent acute pancreatitis (minimum of two confirmed pancreatitis attacks). The primary endpoint is time to acute pancreatitis recurrence after randomization. Secondary outcomes include changes in quality of life, gastrointestinal symptom scores, new-onset diabetes, exocrine pancreatic insufficiency, disease severity, health care utilization, adherence to treatment, and frequency of adverse events. Exploratory outcomes are included for mechanistic linkage and include the progression of chronic pancreatitis-related findings on magnetic resonance imaging (MRI) and changes in circulating blood markers of inflammation and fibrosis.DiscussionThis study investigates if naldemedine can change the natural course of pancreatitis in patients with recurrent acute pancreatitis and improve patient outcomes. BACKGROUND: Acute and chronic pancreatitis constitute a continuum of inflammatory disease of the pancreas with an increasing incidence in most high-income countries. A subset of patients with a history of pancreatitis suffer from recurrence of acute pancreatitis attacks, which accelerate disease progression towards end-stage chronic pancreatitis with loss of exocrine and endocrine function. There is currently no available prophylactic treatment for recurrent acute pancreatitis apart from removing risk factors, which is not always possible. Pain is the primary symptom of acute pancreatitis, which induces the endogenous release of opioids. This may further be potentiated by opioid administration for pain management. Increased exposure to opioids leads to potentially harmful effects on the gastrointestinal tract, including, e.g. increased sphincter tones and decreased fluid secretion, which may impair pancreatic ductal clearance and elevate the risk for new pancreatitis attacks and accelerate disease progression. Peripherally acting µ-opioid receptor antagonists (PAMORAs) have been developed to counteract the adverse effects of opioids on the gastrointestinal tract. We hypothesize that the PAMORA naldemedine will reduce the risk of new pancreatitis attacks in patients with recurrent acute pancreatitis and hence decelerate disease progression. METHODS: The study is a double-blind, randomized controlled trial with allocation of patients to either 0.2 mg naldemedine daily or matching placebo for 12 months. A total of 120 outpatients will be enrolled from five specialist centres in Denmark and Sweden. The main inclusion criteria is a history of recurrent acute pancreatitis (minimum of two confirmed pancreatitis attacks). The primary endpoint is time to acute pancreatitis recurrence after randomization. Secondary outcomes include changes in quality of life, gastrointestinal symptom scores, new-onset diabetes, exocrine pancreatic insufficiency, disease severity, health care utilization, adherence to treatment, and frequency of adverse events. Exploratory outcomes are included for mechanistic linkage and include the progression of chronic pancreatitis-related findings on magnetic resonance imaging (MRI) and changes in circulating blood markers of inflammation and fibrosis. DISCUSSION: This study investigates if naldemedine can change the natural course of pancreatitis in patients with recurrent acute pancreatitis and improve patient outcomes. TRIAL REGISTRATION: EudraCT no. 2021-000069-34. CLINICALTRIALS: gov NCT04966559. Registered on July 8, 2021.
Published: 2023

16. Opioids in the Treatment of Chronic Idiopathic Diarrhea in Humans—A Systematic Review and Treatment Guideline

Author: Christoffer S. Graven-Nielsen, Cecilie S. Knoph, Tina Okdahl, Katrine L. Høyer, Klaus Krogh, Per M. Hellström, and Asbjørn M. Drewes
Subjects: chronic, Cancer och onkologi, Cancer and Oncology, diarrhea, idiopathic, opioids, General Medicine, guidelines
Abstract: In patients with chronic idiopathic diarrhea resistant to standard treatment, opioids are often used as rescue therapy. This systematic review investigated opioid effects on gut function in chronic diarrhea. PubMed and Embase were searched regarding effects of opioid agonists on the gastrointestinal tract in humans with chronic or experimentally induced diarrhea. A total of 1472 relevant articles were identified and, after thorough evaluation, 11 clinical trials were included. Generally, studies reported a reduction in stool frequency and an increase in transit time during treatment with the opioid receptor agonists loperamide, asimadoline, casokefamide, and codeine compared with placebo. Loperamide and diphenoxylate significantly improved stool consistency compared with placebo, whereas asimadoline showed no such effects. Compared with placebo, loperamide treatment caused less abdominal pain and urgency. Asimadoline showed no significant subjective improvements, but fedotozine was superior to placebo in reducing abdominal pain and bloating in selected patients. Only two relevant studies were published within the last 20 years, and standardized endpoint measures are lacking. Most trials included few participants, and further evidence is needed from larger, prospective studies. Likewise, consensus is needed to standardize endpoints for stool frequency, transit time, and consistency to conduct future meta-analyses on opioids in management of chronic idiopathic diarrhea. In patients with chronic idiopathic diarrhea resistant to standard treatment, opioids are often used as rescue therapy. This systematic review investigated opioid effects on gut function in chronic diarrhea. PubMed and Embase were searched regarding effects of opioid agonists on the gastrointestinal tract in humans with chronic or experimentally induced diarrhea. A total of 1472 relevant articles were identified and, after thorough evaluation, 11 clinical trials were included. Generally, studies reported a reduction in stool frequency and an increase in transit time during treatment with the opioid receptor agonists loperamide, asimadoline, casokefamide, and codeine compared with placebo. Loperamide and diphenoxylate significantly improved stool consistency compared with placebo, whereas asimadoline showed no such effects. Compared with placebo, loperamide treatment caused less abdominal pain and urgency. Asimadoline showed no significant subjective improvements, but fedotozine was superior to placebo in reducing abdominal pain and bloating in selected patients. Only two relevant studies were published within the last 20 years, and standardized endpoint measures are lacking. Most trials included few participants, and further evidence is needed from larger, prospective studies. Likewise, consensus is needed to standardize endpoints for stool frequency, transit time, and consistency to conduct future meta-analyses on opioids in management of chronic idiopathic diarrhea.
Published: 2023

17. Exocrine pancreas insufficiency in chronic pancreatitis – Risk factors and associations with complications. A multicentre study of 1869 patients

Author: Friedemann Erchinger, Trond Engjom, Georg Dimcevski, Asbjørn M. Drewes, Søren Schou Olesen, Miroslav Vujasinovic, Johannes-Matthias Löhr, Camilla Nøjgaard, Srdan Novovic, Johanna Laukkarinen, Mikael Parhiala, Lindkvist Björn, Anne Waage, Truls Hauge, Aldis Pukitis, Imanta Ozola-Zalite, Evangelos Kalaitzakis, Alexey Okhlobystin, Giederius Barauskas, Dahl Eva Efsen, Erling Tjora, Tampere University, Department of Gastroenterology, and Clinical Medicine
Subjects: VITAMIN-D DEFICIENCY, LONG-TERM, PREDICTION, Endocrinology, Diabetes and Metabolism, Constriction, Pathologic, GUIDELINES, DIAGNOSIS, 3121 Internal medicine, THERAPY, Risk Factors, Pancreatitis, Chronic, Humans, Pancreatitis, Chronic/complications, NATURAL COURSE, Constriction, Pathologic/complications, Exocrine Pancreatic Insufficiency/complications, Hepatology, Gastroenterology, MALNUTRITION, 3126 Surgery, anesthesiology, intensive care, radiology, Pancreas, Exocrine, PREVALENCE, Cross-Sectional Studies, Exocrine Pancreatic Insufficiency, SMOKING
Abstract: Background/objectives: There is scarce information about risk factors for exocrine pancreas insufficiency (EPI) in chronic pancreatitis (CP), and how it associates with other complications. The aim of the present study was to examine risk factors for EPI and associations to procedures and other CP related complications in a large, Northern European cohort.Patients and methods: We retrieved cross-sectional data on demographics, status on EPI, aetiological risk factors for CP, CP related complications as well as surgical and endoscopic treatment from the Scandinavian Baltic Pancreatic Club Database. Associations were assessed by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals.Results: We included 1869 patients with probable or definitive CP in the study. Exocrine pancreas insufficiency was present in 849 (45.4%) of patients. In multivariate analyses, EPI associated with smoking aetiology (OR 1.47 (1.20-1.79), p < 0.001), and nutritional/metabolic aetiology (OR 0.52 (0.31-0.87), p = 0.01) to CP. Pancreatic or common bile duct stenting procedure and pancreatic resection were both associated with EPI (ORs 1.44 (1.15-1.80), p = 0.002 and 1.54 (1.02-2.33), p = 0.04, respectively). The presence of diabetes mellitus (OR 2.45 (1.92-3.15), p < 0.001), bile duct stenosis (OR 1.48 (1.09-2.00), p = 0.02) and underweight (2.05 (OR 1.40-3.02), p < 0.001) were all associated with presence of EPI.Conclusions: Smoking, bile duct stenosis, previous stenting and resection procedures are all associated with EPI in patients with CP. Presence of EPI were also associated with malnutrition and diabetes mellitus. Hence, intensive nutritional surveillance is needed in these patients. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.
Published: 2022

18. Bowel dysfunction following pelvic organ cancer:a prospective study on the treatment effect in nurse-led late sequelae clinics

Author: Mira Mekhael, Helene M. Larsen, Michael B. Lauritzen, Ole Thorlacius-Ussing, Søren Laurberg, Klaus Krogh, Asbjørn M. Drewes, Peter Christensen, and Therese Juul
Subjects: Male, Constipation/therapy, Hematology, General Medicine, Cancer sequelae, Pelvic Neoplasms/complications, Nurse's Role, Treatment Outcome, Oncology, pelvic organ cancer, Surveys and Questionnaires, Flatulence/complications, bowel dysfunction, Quality of Life, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Fecal Incontinence/etiology, nurse-led treatment
Abstract: BACKGROUND: Bowel dysfunction following treatment of pelvic organ cancer is prevalent and impacts the quality of life (QoL). The present study aimed to evaluate the feasibility and effects of treating bowel dysfunction in two nurse-led late sequelae clinics.MATERIAL AND METHODS: Treatment effects were monitored prospectively by patient-reported outcome measures collected at baseline and discharge. Change in bowel function was evaluated by 15 bowel symptoms, the St. Mark's Incontinence Score, the Patients Assessment of Constipation-Symptoms (PAC-SYM) score and self-rated bowel function. QoL was evaluated by the EuroQol 5-dimension 5-level (EQ-5D-5L) utility score and by measuring the impact of bowel function on QoL.RESULTS: From June 2018 to December 2021, 380 cancer survivors (46% rectal, 15% gynaecological, 13% anal, 12% colon, 12% prostate, and 2% other cancers) completed a baseline questionnaire and started treatment for bowel dysfunction. At referral, 96% of patients were multisymptomatic. The most frequent symptoms were faecal urgency (95%), fragmented defaecation (93%), emptying difficulties (92%), flatus/faecal incontinence (flatus 89%, liquid 59%, solid 33%), and obstructed defaecation (79%). In total, 169 patients were discharged from the clinics in the follow-up period. At discharge, 69% received conservative treatment only and 24% also received transanal irrigation; 4% were surgically treated; 3% discontinued treatment. Improvements were seen in all 15 bowel symptoms ( p CONCLUSION: Treatment of bowel dysfunction in nurse-led late sequelae clinics is feasible and significantly improved bowel function and QoL.
Published: 2023

19. Electrocardiography Assessment of Sympatico–Vagal Balance during Resting and Pain Using the Texas Instruments ADS1299

Author: Donghua Liao, Rasmus B. Nedergaard, Misbah Unnisa, Soumya J. Mahapatra, Mahya Faghih, Anna E. Phillips, Dhiraj Yadav, Vikesh K. Singh, Søren S. Olesen, Rupjyoti Talukdar, Pramod K. Garg, Imran K. Niazi, Christina Brock, and Asbjørn M. Drewes
Subjects: electrocardiography (ECG), sympatico–vagal balance, biomarkers, cold pressor test, Bioengineering
Abstract: Sympatico–vagal balance is essential for regulating cardiac electrophysiology and plays an important role in arrhythmogenic conditions. Various noninvasive methods, including electrocardiography (ECG), have been used for clinical assessment of the sympatico–vagal balance. This study aimed to use a custom-designed wearable device to record ECG and ECG-based cardiac function biomarkers to assess sympatico–vagal balance during tonic pain in healthy controls. Nineteen healthy volunteers were included for the ECG measurements using the custom-designed amplifier based on the Texas Instruments ADS1299. The ECG-based biomarkers of the sympatico–vagal balance, (including heart rate variability, deceleration capacity of the heart rate, and periodic repolarization dynamic), were calculated and compared between resting and pain conditions (tonic pain). The custom-designed device provided technically satisfactory ECG recordings. During exposure to tonic pain, the periodic repolarization dynamics increased significantly (p = 0.02), indicating enhancement of sympathetic nervous activity. This study showed that custom-designed wearable devices can potentially be useful in healthcare as a new telemetry technology. The ECG-based novel biomarkers, including periodic repolarization dynamic and deceleration capacity of heart rate, can be used to identify the cold pressor-induced activation of sympathetic and parasympathetic systems, making it useful for future studies on pain-evoked biomarkers. Sympatico-vagal balance is essential for regulating cardiac electrophysiology and plays an important role in arrhythmogenic conditions. Various noninvasive methods, including electrocardiography (ECG), have been used for clinical assessment of the sympatico-vagal balance. This study aimed to use a custom-designed wearable device to record ECG and ECG-based cardiac function biomarkers to assess sympatico-vagal balance during tonic pain in healthy controls. Nineteen healthy volunteers were included for the ECG measurements using the custom-designed amplifier based on the Texas Instruments ADS1299. The ECG-based biomarkers of the sympatico-vagal balance, (including heart rate variability, deceleration capacity of the heart rate, and periodic repolarization dynamic), were calculated and compared between resting and pain conditions (tonic pain). The custom-designed device provided technically satisfactory ECG recordings. During exposure to tonic pain, the periodic repolarization dynamics increased significantly ( p = 0.02), indicating enhancement of sympathetic nervous activity. This study showed that custom-designed wearable devices can potentially be useful in healthcare as a new telemetry technology. The ECG-based novel biomarkers, including periodic repolarization dynamic and deceleration capacity of heart rate, can be used to identify the cold pressor-induced activation of sympathetic and parasympathetic systems, making it useful for future studies on pain-evoked biomarkers.
Published: 2023

20. The safety and efficacy of epidural anaesthesia in acute pancreatitis:a systematic review and meta-analysis

Author: Dhya Al-Leswas, Nesta Baxter, Wei B. Lim, Francis Robertson, Bathiya Ratnayake, Jayanta Samanta, Gabriele Capurso, Enrique de-Madaria, Asbjørn M. Drewes, John Windsor, and Sanjay Pandanaboyana
Subjects: Hepatology, Gastroenterology
Abstract: BACKGROUND: Acute pancreatitis (AP) has variable clinical courses. This systematic review and meta-analysis aimed to determine the safety, efficacy, and impact of epidural anaesthesia (EA) use in AP.METHODS: The PubMed, EMBASE, SCOPUS and Cochrane library databases were systematically searched between 1980 and 2022 using the PRISMA guidelines, to identify observational and comparative studies reporting on EA in AP. The meta-analysis was performed in R Foundation for Statistical Computing using the meta R Package for Meta-Analysis.RESULTS: A total of 9 studies with 2006 patients of which 726 (36%) patients had EA were included. All studies demonstrated high safety and feasibility of EA in AP with no reported major local or neurological complications. One randomised controlled trial demonstrated an improvement in pain severity using a 0-10 visual analogue scale (VAS) at the outset (1.6 in EA vs 3.5 in non-EA, P = 0.02) and on day 10 (0.2 in EA vs 2.33 in non-EA, P = 0.034). There was also improvement in pancreatic perfusion with EA measured with computerised tomography 13 (43%) in EA vs 2 (7%) in non-EA, P = 0.003. The need for ventilatory support and overall mortality was lower in EA patients 40 (19%) vs 285 (24%) P = 0.025 (OR: 0.49, 95% CI: 0.28-0.84) and 16 (7%) vs 214 (20%), P = 0.050 (OR: 0.39, 95% CI: 0.15-1.00), respectively.CONCLUSION: EA is infrequently used for pain management in AP and yet the available evidence suggests that it is safe and effective in reducing pain severity, improving pancreatic perfusion, and decreasing mortality.
Published: 2023

21. DIgestive COmplications in DIabetes : the DICODI population study

Author: Moeen Ud-din, Bassam Karout, Wiktoria M. Torbé, Johan Lunding, Anne-Marie Wegeberg, Asbjørn M. Drewes, Christina Brock, and Per M. Hellström
Subjects: pancreatic exocrine insufficiency, complications, gastroparesis, Gastroenterology, Gastroenterologi, Celiac disease, gastroenteropathy, metabolic control, Gastroenterology and Hepatology
Abstract: BACKGROUND: Diabetes type 1 and type 2 may develop gastrointestinal complications e.g., gastroparesis and gastroenteropathy. Concomitant celiac disease and pancreatic exocrine insufficiency occur with high prevalence in diabetes and with symptomatic overlap. Consequently, it is a challenge to disentangle symptoms of these conditions and separate them from functional dyspepsia. We aim to develop a clinical decision-support tool to differentiate the underlying disease in a plethora of gastrointestinal symptoms.METHODS: An internet-based computerized survey will collect basic characteristics (diabetes type, age, gender, duration, HbA1c, treatment) and patient reported outcomes by validated questionnaires focusing on (1) gastroparesis using Gastroparesis Cardinal Symptom Index; (2) gastroenteropathy using Gastrointestinal Symptom Rating Scale; (3) celiac disease using Celiac Symptom Index and (4) pancreatic exocrine insufficiency with Pancreatic Exocrine Insufficiency Questionnaire. Logistic regression and multiple regression analyses will identify risk factors and gastrointestinal complications. Cluster analyses and machine learning will classify different symptoms and co-existing presentations, into a likely diagnosis. We seek biomarkers for autonomic neuropathy by characterizing development of retinopathy using the Visual Function Questionnaire-25 and peripheral neuropathy by the Michigan neuropathy questionnaire. Participants are re-examined yearly for disease progression over time.RESULTS: From focus group studies gastrointestinal symptoms are of major concern in diabetes. Potentially, estimates of symptom prevalence, risk factor identification and classifications of gastrointestinal complications can be unraveled for feedback to health care providers.CONCLUSION: The web-based DICODI project will open up possibilities to detect gastrointestinal complications of diabetes in a societal setting, benefitting people living with diabetes, health care professionals, and society.
Published: 2023

22. Inter- and intra-observer variability of computed tomography-based parenchymal- and ductal diameters in chronic pancreatitis:a multi-observer international study

Author: Jens Borgbjerg, Emily Steinkohl, Søren S. Olesen, Fatih Akisik, Anne Bethke, Edita Bieliuniene, Heidi S. Christensen, Trond Engjom, Ingfrid S. Haldorsen, Nikolaos Kartalis, Maria V. Lisitskaya, Gintare Naujokaite, Srdan Novovic, Imanta Ozola-Zālīte, Anna E. Phillips, Jordan K. Swensson, Asbjørn M. Drewes, and Jens B. Frøkjær
Subjects: Radiological and Ultrasound Technology, Urology, Observer agreement, Gastroenterology, Radiology, Nuclear Medicine and imaging, Chronic pancreatitis, Computed tomography
Abstract: Purpose: The need for incorporation of quantitative imaging biomarkers of pancreatic parenchymal and ductal structures has been highlighted in recent proposals for new scoring systems in chronic pancreatitis (CP). To quantify inter- and intra-observer variability in CT-based measurements of ductal- and gland diameters in CP patients. Materials and Methods: Prospectively acquired pancreatic CT examinations from 50 CP patients were reviewed by 12 radiologists and four pancreatologists from 10 institutions. Assessment entailed measuring maximum diameter in the axial plane of four structures: (1) pancreatic head (PDhead), (2) pancreatic body (PDbody), (3) main pancreatic duct in the pancreatic head (MPDhead), and (4) body (MPDbody). Agreement was assessed by the 95% limits of agreement with the mean (LOAM), representing how much a single measurement for a specific subject may plausibly deviate from the mean of all measurements on the specific subject. Bland–Altman limits of agreement (LoA) were generated for intra-observer pairs. Results: The 16 observers completed 6400 caliper placements comprising a first and second measurement session. The widest inter-observer LOAM was seen with PDhead (± 9.1 mm), followed by PDbody (± 5.1 mm), MPDhead (± 3.2 mm), and MPDbody (± 2.6 mm), whereas the mean intra-observer LoA width was ± 7.3, ± 5.1, ± 3.7, and ± 2.4 mm, respectively. Conclusion: Substantial intra- and inter-observer variability was observed in pancreatic two-point measurements. This was especially pronounced for parenchymal and duct diameters of the pancreatic head. These findings challenge the implementation of two-point measurements as the foundation for quantitative imaging scoring systems in CP. Graphical abstract: [Figure not available: see fulltext.]
Published: 2023

23. Surgical strategies for chronic pancreatitis in a 1,327- patient Scandinavian Baltic pancreatic Club (SBPC) register

Author: Mikael Parhiala, Anne Waage, Povilas Ignatavičius, Søren S. Olesen, Jakob L. Poulsen, Engjom Trond, Georg Dimcevski, Ingrid Nordaas, Amer Hadi, Evangelos Kalaitzakis, Asbjørn M. Drewes, Camilla Nøjgaard, and Johanna Laukkarinen
Subjects: Quality of life, Cross-Sectional Studies, Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology, Humans, Pain, Surgery, Chronic Pain, Pancreatic Hormones, Chronic pancreatitis, Pancreatitis, Chronic/surgery
Abstract: BACKGROUND: Chronic pancreatitis (CP) may cause intermittent or continuous pain and complications requiring invasive interventions. No specific recommendations for surgical interventions have been presented. Our aim was to determine the surgical treatment strategies for the treatment of CP in the Scandinavian and Baltic countries.METHODS: This multi-centre cross sectional study included 1327 CP patients from eight centres. The data was gathered from the Scandinavian Baltic Pancreatic Club (SBPC) database. Patients who underwent pancreatic surgery were analysed. The baseline CP population from the eight centres was used as a reference. The information registered included comorbidities, pancreatic function, previous interventions, time and type of surgery and the EORTC-30 quality of life (QOL) questionnaire.RESULTS: Overall, 95/1327 (7%) patients underwent pancreatic surgery. Fifty-one (54%) of these underwent pancreatic surgery for chronic pain (PSCP) and formed the final study group. Median follow-up time was two (range 0-8) years after surgery and seven (1-46) years after diagnosis. The most common surgical procedures were pancreatic resection combined with drainage (54%) followed by pancreatic resections (32%) and drainage procedures (14%). Postoperatively, 47% of the patients were pain free with or without pain medication while 16% had chronic pain episodes, this did not differ from the base CP population. In QOL questionnaires, PSCP patients reported the same QOL but worse social functioning and more symptoms compared to the CP population.CONCLUSIONS: Pancreatic surgery for CP is rare: surgical procedures were performed on only 7% of the CP patients in the SBPC database. In half of the patients the indication was pain. Most of these patients underwent endoscopic procedures before surgery. Half of the patients reported being pain-free after surgery.
Published: 2023

24. Reply

Author: Louise Kuhlmann, Søren S. Olesen, John A. Windsor, and Asbjørn M. Drewes
Subjects: Hepatology, Gastroenterology
Published: 2022

25. Editorial:Introduction to the issue: state of the art for managing pancreatic diseases

Author: Dhiraj Yadav, Soren S. Olesen, and Asbjørn M. Drewes
Subjects: Gastroenterology, Pancreatic Diseases, Humans, Pancreatic Diseases/therapy
Published: 2022

26. The impact of type 2 diabetes on long-term gastrointestinal sequelae after colorectal cancer surgery:national population-based study

Author: Tinne Laurberg, Sara Frandsen, Helene M Larsen, Louise L Lehrskov, Susanne B Graversen, Asbjørn M Drewes, Katrine J Emmertsen, and Klaus Krogh
Subjects: Postoperative Complications/epidemiology, Rectal Neoplasms, Diabetes Mellitus, Type 2/complications, Pain, General Medicine, Syndrome, Postoperative Complications, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Quality of Life, Humans, Neoplasm Recurrence, Local, Constipation, Colectomy, Constipation/epidemiology
Abstract: Background Long-term gastrointestinal sequelae are common after colorectal cancer surgery, but the impact of type 2 diabetes (T2D) is unknown. Methods In a cross-sectional design, questionnaires regarding bowel function and quality of life (QoL) were sent to all Danish colorectal cancer survivors, who had undergone surgery between 2001 and 2014 and had more than 2 years follow-up without relapse. The prevalence of long-term gastrointestinal sequelae among colorectal cancer survivors with and without T2D were compared while stratifying for type of surgical resection and adjusting for age, sex, and time since surgery. Results A total of 8747 out of 14 488 colorectal cancer survivors answered the questionnaire (response rate 60 per cent), consisting of 3116 right-sided colonic, 2861 sigmoid, and 2770 rectal resections. Of these, 690 (7.9 per cent) had a diagnosis of T2D before surgery. Survivors with T2D following rectal resection had a 15 per cent (95 per cent c.i. 7.8 to 22) higher absolute risk of major low anterior resection syndrome, whereas survivors with T2D following right-sided and sigmoid resection had an 8 per cent higher risk of constipation (P Conclusion T2D at time of surgery was associated with a higher risk of long-term bowel dysfunction after rectal resection, but not after colon resection excluding a higher risk of constipation. T2D was associated with a slightly higher frequency of severe pain and inferior QoL after both rectal and colonic cancer resection.
Published: 2022

27. Inter- and intra-observer variability of computed tomography-based parenchymal- and ductal diameters in chronic pancreatitis: a multi-observer international study

Author: Jens, Borgbjerg, Emily, Steinkohl, Søren S, Olesen, Fatih, Akisik, Anne, Bethke, Edita, Bieliuniene, Heidi S, Christensen, Trond, Engjom, Ingfrid S, Haldorsen, Nikolaos, Kartalis, Maria V, Lisitskaya, Gintare, Naujokaite, Srdan, Novovic, Imanta, Ozola-Zālīte, Anna E, Phillips, Jordan K, Swensson, Asbjørn M, Drewes, and Jens B, Frøkjær
Abstract: The need for incorporation of quantitative imaging biomarkers of pancreatic parenchymal and ductal structures has been highlighted in recent proposals for new scoring systems in chronic pancreatitis (CP). To quantify inter- and intra-observer variability in CT-based measurements of ductal- and gland diameters in CP patients.Prospectively acquired pancreatic CT examinations from 50 CP patients were reviewed by 12 radiologists and four pancreatologists from 10 institutions. Assessment entailed measuring maximum diameter in the axial plane of four structures: (1) pancreatic head (PDhead), (2) pancreatic body (PDbody), (3) main pancreatic duct in the pancreatic head (MPDhead), and (4) body (MPDbody). Agreement was assessed by the 95% limits of agreement with the mean (LOAM), representing how much a single measurement for a specific subject may plausibly deviate from the mean of all measurements on the specific subject. Bland-Altman limits of agreement (LoA) were generated for intra-observer pairs.The 16 observers completed 6400 caliper placements comprising a first and second measurement session. The widest inter-observer LOAM was seen with PDhead (± 9.1 mm), followed by PDbody (± 5.1 mm), MPDhead (± 3.2 mm), and MPDbody (± 2.6 mm), whereas the mean intra-observer LoA width was ± 7.3, ± 5.1, ± 3.7, and ± 2.4 mm, respectively.Substantial intra- and inter-observer variability was observed in pancreatic two-point measurements. This was especially pronounced for parenchymal and duct diameters of the pancreatic head. These findings challenge the implementation of two-point measurements as the foundation for quantitative imaging scoring systems in CP.
Published: 2022

28. Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality in Postpancreatitis Diabetes Mellitus Versus Type 2 Diabetes:A Nationwide Population-Based Cohort Study

Author: Søren S. Olesen, Rikke Viggers, Asbjørn M. Drewes, Peter Vestergaard, and Morten H. Jensen
Subjects: Advanced and Specialized Nursing, Adult, Cohort Studies, Diabetes Mellitus, Type 2, Pancreatitis, Cardiovascular Diseases, Risk Factors, Endocrinology, Diabetes and Metabolism, Internal Medicine, Humans, Hypoglycemic Agents, Hypoglycemia
Abstract: OBJECTIVE Postpancreatitis diabetes mellitus (PPDM) is a frequent complication of pancreatitis and associates with poor glycemic control. We investigated the risk of adverse diabetes-related outcomes in PPDM compared with type 2 diabetes. RESEARCH DESIGN AND METHODS In this Danish population-based cohort study, we included adults (>18 years) with incident PPDM or type 2 diabetes between 1998 and 2018 through national health registries. PPDM was further divided into acute (PPDM-A) and chronic (PPDM-C) subtypes. We ascertained risk of major adverse cardiovascular events (MACE), severe hypoglycemia, and all-cause mortality as well as incidence rates of severe hypoglycemia. We compared risk and incidence rates across diabetes subgroups using multivariate Cox and Poisson regression analyses. RESULTS We identified 383,325 people with incident type 2 diabetes, 3,418 with PPDM-A, and 2,461 with PPDM-C. Compared with type 2 diabetes, PPDM-C was associated with increased risks of severe hypoglycemia (hazard ratio [HR] 5.27, 95% CI 4.62–6.00, P < 0.001) and all-cause mortality (HR 1.54, 95% CI 1.45–1.64, P < 0.001). Similar patterns were observed for people with PPDM-A. Incidence rate ratios (IRRs) for severe hypoglycemia were increased in both PPDM-C (IRR 7.38, 95% CI 6.75–8.08, P < 0.001) and PPDM-A (IRR 3.76, 95% CI 3.36–4.21, P < 0.001) compared with type 2 diabetes. Findings were consistent in an analysis restricted to people on insulin and in an analysis including pancreatitis patients without diabetes as comparator group. CONCLUSIONS Compared with type 2 diabetes, PPDM is associated with excess risk of adverse diabetes-related outcomes. This has important implications for management.
Published: 2022

29. CLINICAL COURSE OF MEDICALLY MANAGED PATIENTS WITH LARGE AND SMALL DUCT CHRONIC PANCREATITIS

Author: Marco B. Mahdi, Emily Steinkohl, Vikesh K. Singh, Asbjørn M. Drewes, Jens B. Frøkjær, and Søren S. Olesen
Subjects: Gastroenterology
Abstract: INTRODUCTION: Pancreatic duct obstruction is the primary indication for endoscopic and/or surgical therapy in patients with chronic pancreatitis (CP). However, the clinical course of medically managed patients in relation to pancreatic duct obstruction is largely unknown. METHODS: This was a retrospective cohort study of medically managed patients with CP. We classified patients based on pancreatic duct obstruction from a stricture or stone using cross-sectional imaging (i.e., large vs small duct CP). We compared prevalence of diabetes and exocrine insufficiency (EPI) between subgroups at inclusion and investigated risk of new-onset diabetes, EPI, and all-cause mortality over a follow-up period of 5 years. Changes in pancreatic morphology were studied in patients who underwent follow-up imaging. RESULTS: A total of 198 patients (mean age 58 ± 12 years, 70% male, 60% alcoholic etiology, 38% large duct CP) were evaluated. At inclusion, patients with large vs small duct CP had a higher prevalence of both diabetes (43% vs 24%, P = 0.004) and EPI (47% vs 28%, P = 0.007). There was an increased risk of new-onset EPI in patients with large duct CP (hazard ratio 1.72; 95% confidence interval [1.05-2.80], P = 0.031) and higher rates of pancreatic atrophy ( P < 0.001). No differences between groups were observed for new-onset diabetes and all-cause mortality. Conversion from small to large duct CP or vice versa during follow-up was observed in 14% of patients. DISCUSSION: In a medically managed cohort of patients, large duct CP was associated with increased risk of EPI and pancreatic atrophy compared with small duct CP.
Published: 2022

30. Self-perceived functioning and (instrumental) activities of daily living questionnaires after a hip fracture: Do they tell the same story?

Author: Willeke M Ravensbergen, Irie L Timmer, Jacobijn Gussekloo, Jeanet W Blom, Monica van Eijk, Wilco P Achterberg, Andrea W M Evers, Sandra van Dijk, and Yvonne M Drewes
Subjects: Aged, 80 and over, Aging, Hip Fractures, Surveys and Questionnaires, Activities of Daily Living, Humans, General Medicine, Prospective Studies, Geriatrics and Gerontology, Aged, Netherlands
Abstract: Background (Instrumental) activities of daily living ((I)ADL) questionnaires are often used as a measure of functioning for different purposes. Depending on the purpose, a measurement of functioning that includes subjective patient perspectives can be relevant. However, it is unclear to what extent (I)ADL instruments capture self-perceived functioning. Objective Explore what functioning means to older persons after a hip fracture and assess the extent to which (I)ADL instruments align with self-perceived functioning. Design Qualitative interview study with framework analysis. Setting Prospective cohort study on recovery after a hip fracture among older persons in a hospital in a large city in the west of the Netherlands. Subjects Eighteen home-dwelling older persons (≥70 years) who had a hip fracture 6–12 months ago. Methods Telephone interviews about functioning before and after the hip fracture were coded and analysed using the framework method. Results The activities mentioned by participants to be part of their self-perceived functioning could be split into activities necessary to maintain the desired level of independence, and more personal activities that were of value to participants. Both the ‘independence activities’ and the ‘valued activities’ mentioned went beyond the activities included in (I)ADL questionnaires. Due to various coping strategies, limitations in activities that are measured in the (I)ADL questionnaires did not necessarily lead to worse self-perceived functioning. Conclusion Self-perceived functioning differs from functioning measured with (I)ADL questionnaires in the items included and the weighing of limitations in activities. Thus, (I)ADL instruments alone are not enough to measure functioning from the perspective of the older person.
Published: 2022

31. Do we AGREE on the targets of antihypertensive drug treatment in older adults: a systematic review of guidelines on primary prevention of cardiovascular diseases

Author: Leonie M von Ballmoos, Jonathan M. K. Bogaerts, Rosalinde K. E. Poortvliet, Yvonne M. Drewes, Jacobijn Gussekloo, Milly A. van der Ploeg, Wilco P. Achterberg, and Sven Streit
Subjects: Aging, medicine.medical_specialty, Octogenarians, medicine.drug_class, Biological age, Population, 610 Medicine & health, Context (language use), Blood Pressure, older people, AcademicSubjects/MED00280, systematic review, 360 Social problems & social services, Primary prevention, medicine, Humans, Agree ii, guidelines, Antihypertensive drug, education, Intensive care medicine, Antihypertensive Agents, Aged, Aged, 80 and over, education.field_of_study, business.industry, General Medicine, Guideline, Primary Prevention, Editorial, Blood pressure, Cardiovascular Diseases, Hypertension, primary cardiovascular prevention, Geriatrics and Gerontology, business, antihypertensive drug therapy
Abstract: Background translation of the available evidence concerning primary cardiovascular prevention into clinical guidance for the heterogeneous population of older adults is challenging. With this review, we aimed to give an overview of the thresholds and targets of antihypertensive drug therapy for older adults in currently used guidelines on primary cardiovascular prevention. Secondly, we evaluated the relationship between the advised targets and guideline characteristics, including guideline quality. Methods we systematically searched PubMed, Embase, Emcare and five guideline databases. We selected guidelines with (i) numerical thresholds for the initiation or target values of antihypertensive drug therapy in context of primary prevention (January 2008–July 2020) and (ii) specific advice concerning antihypertensive drug therapy in older adults. We extracted the recommendations and appraised the quality of included guidelines with the AGREE II instrument. Results thirty-four guidelines provided recommendations concerning antihypertensive drug therapy in older adults. Twenty advised a higher target of systolic blood pressure (SBP) for octogenarians in comparison with the general population and three advised a lower target. Over half of the guidelines (n = 18) recommended to target a SBP Conclusion the ongoing debate concerning targets of antihypertensive treatment in older adults, is reflected in an inconsistency of recommendations across guidelines. Recommended targets are largely set on chronological rather than biological age.
Published: 2021

32. 103PERSPECTIVES ON QUALITY OF TRANSITIONAL CARE FROM HOSPITAL TO HOME FOR VULNERABLE OLDER PATIENTS

Author: Jacobijn Gussekloo, Yvonne M. Drewes, G Willemsen, L S van Tol, Laura C. Blomaard, and S Kuipers
Subjects: Aging, medicine.medical_specialty, Older patients, business.industry, media_common.quotation_subject, Family medicine, Medicine, Transitional care, Quality (business), General Medicine, Geriatrics and Gerontology, business, media_common
Published: 2019

33. Corrigendum to 'Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis' [Pancreatology 22 (1) (January 2022) 20–29]

Author: Furqan A. Bhullar, Mahya Faghih, Venkata S. Akshintala, Ahmed I. Ahmed, Katie Lobner, Elham Afghani, Anna E. Phillips, Phil A. Hart, Mitchell L. Ramsey, Benjamin L. Bick, Louise Kuhlmann, Asbjørn M. Drewes, Dhiraj Yadav, Søren S. Olesen, and Vikesh K. Singh
Subjects: Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published: 2022

34. Cortical processing to anorectal stimuli after rectal resection with and without radiotherapy

Author: S, Haas, P M, Faaborg, M, Gram, L, Lundby, C, Brock, A M, Drewes, S, Laurberg, K, Krogh, and P, Christensen
Subjects: Proctectomy, Manometry, Rectal Neoplasms, Rectum, Anal Canal, Humans, Digestive System Surgical Procedures
Abstract: Bowel dysfunction is common after surgery for rectal cancer, especially when neoadjuvant radiotherapy is used. The role of sensory function in the pathogenesis remains obscure, and the aim of the present study was to characterize the sensory pathways of the brain-gut axis in rectal cancer patients treated with resection ± radiotherapy compared with healthy volunteers.Sensory evaluation by (neo)rectal distensions was performed and sensory evoked potentials (SEPs) were recorded during rapid balloon distensions of the (neo)rectum and anal canal in resected patients with (n = 8) or without (n = 12) radiotherapy. Twenty healthy volunteers were included for comparison. (Neo)rectal latencies and amplitudes of SEPs were compared and spectral band analysis from (neo)rectal and anal distensions was used as a proxy of neuronal processing.Neorectal sensation thresholds were significantly increased in both patient categories (all p 0.008). There were no differences in (neo)rectal SEP latencies and amplitudes between groups. However, spectral analysis of (neo)rectal SEPs showed significant differences between all groups in all bands (all p 0.01). On the other hand, anal SEP analyses only showed significant differences between the delta (0-4 Hz), theta (4-8 Hz) and, gamma 32-50 Hz) bands (all p 0.02) between the subgroup of patients that also received radiotherapy and healthy volunteers.Surgery for rectal cancer leads to abnormal cortical processing of neorectal sensation. Additional radiotherapy leads to a different pattern of central sensory processing of neorectal and anal sensations. This may play a role in the functional outcome of these patients.
Published: 2020

35. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author: Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. Zick, Daniel Schulte, R. Santoro, Anna Kulesza, I. Turk Cakir, M. Nonis, Silvia Posada Arias, Livia Soffi, T. Wojtoń, E. Cennini, Florian Bauer, B. Rousset, J.-L. Grenard, C. Neubüser, Frederic Derue, Loukas Gouskos, Rainer Wallny, G. Calderini, M. Merk, M. Mühlegger, Roberto Cimino, M. Ramsey-Musolf, P. Rebello Teles, Mario Galanti, Mikhail Shaposhnikov, A. Andreazza, Maria Vittoria Garzelli, Masaya Ishino, José W. F. Valle, Colin Bernet, G. Velev, Cristina Botta, E. Fischer, J. Malclés, Giuseppe Montenero, Tripurari Srivastava, E. Renner, Shahnam Gorgi Zadeh, D. Cantore-Cavalli, Paul Laycock, J. Komppula, Simon C. Hopkins, Helmut Burkhardt, Eric Lancon, I. Aichinger, Andre Sznajder, F. Bordry, Massimo Giovannozzi, Aidan Robson, Anna Giunta, A. Carvalho, S. Farinon, Daniel Wollmann, M. Fouaidy, Martti Raidal, R. Gerard, Giovanni Volpini, U. Niedermayer, A. Alekou, Alexander J.G. Lunt, Vincenzo Cavasinni, Andrzej Siodmok, U. Kaya, Matthias Schott, Marumi Kado, S. A. Arsenyev, José Zurita, John Osborne, Patrick Meade, Gianmarco Bovone, G. Li, Klaus Schlenga, Antti Stenvall, D. Duellmann, Werner Riegler, I. Garzia, Yasuyuki Okumura, G. Pikurs, F. Maltoni, Massimo Sorbi, M. Arzeo, B. Strauss, Y. W. Baek, Mauro Chiesa, K. Ilyina-Brunner, Javier L. Albacete, R. Farinelli, C. Pes, Nicolas Morange, S. M. Zernov, U. Wagner, Emmanuelle Perez, G. G. Da Silveira, J. Neundorf, Néstor Armesto, T. Hahn, Roman N. Lee, Roderik Bruce, B. Y. Sharkov, T. du Pree, G. Cibinetto, Evelin Meoni, R. Rinaldesi, James A. Ellison, Radim Slovak, Silvia Franchino, Mikko Laine, T. Pugnat, S. P. Das, Yuji Enari, Emanuela Barzi, Cihan Bayindir, R. Boels, Jana Faltova, M. Moreno Llácer, Scott A. Yost, Michael Spannowsky, Florian Burkart, Marcin Chrzaszcz, K. Suzuki, Luca Trentadue, S. Masciocchi, Gilad Perez, Steve Peggs, K. Sugita, Eleonora Belli, Carmine Senatore, K. Y. Oyulmaz, Aldo Deandrea, Irakli Minashvili, Desmond P. Barber, M. I. Martínez-Hernández, A. Apyan, S. Petracca, Mikael Chala, Urs Achim Wiedemann, T. Sian, Olivier Deschamps, R. Monge, G. Avrillaud, Jan Kieseler, Hubert Spiesberger, J. Maitre, G. D. Shirkov, M. Hofer, Emanuela Sirtori, Sinan Kuday, Kirill Skovpen, Sara Casalbuoni, Johann Usovitsch, N. Chen, G. Tejeda-Muñoz, F. Bellini, E. Chyhyrynets, Michael Stöger-Pollach, M. Vogel, J. G. Mendes Saraiva, A. Rivetti, M. Podeur, Luc Poggioli, V. A. Gromov, R. Sirvinskaite, S. B. Leith, Giancarlo D'Ambrosio, Tony Price, Philippe Mermod, Rabindra N. Mohapatra, T. Mitshuhashi, Koji Terashi, Leonel Ferreira, L. Vale Silva, N. Muchnoi, J. L. Stanyard, Thomas Marriott-Dodington, A. Andriatis, Oleg Solovyanov, A. Daljevec, A. Butterworth, S. Myers, D. Chanal, Tatiana Pieloni, M. Rodríguez-Cahuantzi, G. Nardini, D. Boscherini, Kazuhito Ohmi, James Molson, S. Kowalski, Christoph Haberstroh, Martin Aleksa, K. Kershaw, M. Mulder, Leonid Rivkin, G. Vorotnikov, Luigi Salvatore Esposito, J. Kalinowski, Michele Cascella, Francesco Giffoni, Alessandro Polini, Georges Azuelos, M. Prioli, Wolfgang Altmannshofer, S. K. Patra, H. J. He, J. J. Aguilera-Verdugo, Hannu Paukkunen, P. Chomaz, Shoji Asai, Nicolas Magnin, Gavin P. Salam, R. Wang, F. Avino, Alexander Romanenko, A. Rossi, Steve Muanza, Richard Ruiz, Dmitry Teytelman, S. Klöppel, S. Atieh, M. Mohammadi Najafabadi, L. Apolinario, Andrea Tesi, M. Maggiora, A. Falkowski, Janusz Gluza, M. Sauvain, Hamzeh Khanpour, S. Chance, Ansgar Denner, Ma. Greco, Andreas Papaefstathiou, Manuela Boscolo, Joydeep Chakrabortty, E. Franco, R. R. Bosley, G. Peón, Fred Olness, Simone Alioli, Andrea Gaddi, M. K. Sullivan, M. Segreti, M. Panareo, Florian Goertz, Z. G. Zhao, H. Chanal, O. Martin, P. Azzurri, Agnieszka Chmielinska, M. Kordiaczyńska, O. Brunner, J. Von Ahnen, Jose Santiago, K. Foraz, Y. Alexahin, Marcello Mannelli, Christian Schwanenberger, S. Ganjour, Simone Marzani, T. M. Taylor, S. Di Vita, J. Womersley, I. Karpov, Valentina Morretta, Saverio D'Auria, Patrick Draper, B. Hacışahinoğlu, E. Gorini, Andrew J. Long, S. La Mendola, G. Zevi Dell Porta, I. Abdyukhanov, M. Cobal, Luca Marzola, E. Rochepault, A. Kusina, German Rodrigo, R. Schmidt, Jan Steggemann, E. Premat, P. Slavich, F. Gianotti, P. Jarry, Ram Krishna Dewanjee, L. Felsberger, T. Martinez, A. Niemi, Jürgen Reuter, P. A. Bruckman de Renstrom, Ryu Sawada, J. T. Childers, Gelsomina Catalano, P. Barjhoux, O. R. Blanco-García, Pilar Hernández, H. Correia-Rodrigues, V. Ippolito, S. De Curtis, Juan Rojo, Ayberk Yilmaz, S. Baird, Morteza Khatiri Yanehsari, Enrico Scomparin, Daniel Appelö, J. Kozaczuk, Matthew Jones, B. Caiffi, C. Del Bo, Susanna Guiducci, Giuliano Panico, M. Knecht, J. Coupard, M. Ciuchini, H. Kritscher, Claire Gwenlan, P. Costa Pinto, Thibaut Lefèvre, N. Bellegarde, Christian Scheuerlein, P. Ferreira da Silva, M. Verducci, X. Ruan, H. Pikhartova, Juan M. O'Callaghan, Kazuro Furukawa, D. 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Gil Costa, L. K. Gladilin, Yannis Papaphilippou, Michael Spira, Maria Paola Lombardo, M. Fiascaris, Darius A. Faroughy, S. O. Kara, Peter Braun-Munzinger, A. Wohlfahrt, A. A. Krasnov, S.A. Gourlay, W. Da Silva, Jacqueline Keintzel, Radja Boughezal, Renat Sadykov, L. R. Sulak, Valentin V. Khoze, T. Tydecks, S. Puławski, Daniel de Florian, Pedro Schwaller, A. Akay, Nicola Serra, Sukanta Dutta, Christophe Royon, Alessandro Ricci, A. Kuendig, C. G. Honorato, K. Kołodziej, L. Deniau, Michael Kramer, J. Ferradas Troitino, A. Arbey, A. M. Staśto, Marcel Demarteau, Ralph Aßmann, O. Grimm, D. Forkel-Wirth, Owain Rhodri Jones, A. M. Kolano, G. Chiarello, William Trischuk, Andrea Dell'Acqua, Elisabetta Gallo, H. Song, Frank Petriello, N. Ibarrola, C. Colldelram, A. I. Ryazanov, A. Meier, Phillip Allport, J. de Blas, S. Chattopadhyay, Massimo Florio, X. Jiang, Bertrand Baudouy, T. Otto, Tevong You, Christoph Englert, Roberto Pittau, G. M. Bilei, Matthew McCullough, N. S. Ramírez-Uribe, J. Charles, Amalia Ballarino, Federico Antinori, A. V. Kotwal, P. Le Guen, Berndt Müller, Chiara Roda, Xavier Buffat, D. K. Hong, Matthias Liepe, G. Gorine, V. A. Okorokov, D. Bozzini, N. Simand, Giuseppe Francesco Tartarelli, C. Marquet, R. Contino, A. M. Teixeira, R. Trant, Roberto Losito, M. Quispe, Valery I. Telnov, Helga Timko, D. Lissauer, Giulio Aielli, Giorgio Chiarelli, M. J. Baldwin, A. Winter, X. Sarasola, E. E. Boos, Aleandro Nisati, Cedric Garion, Monica D'Onofrio, S. M. Gascon-Shotkin, Daniele Barducci, G. Rosaz, Nathaniel Craig, L. D’Aloia Schwartzentruber, A. Falou, A. Henriques, Tobias Hurth, Michael Eisterer, Andreas Grau, Austin Ball, D. Delikaris, P. A. McIntosh, E. Graverini, Kadri Ozdemir, F. Valchkova, Marco Zanetti, Guenakh Mitselmakher, S. Albergo, Peter Levai, Caterina Vernieri, F. Stivanello, Michael Barnes, Henri Bachacou, Daniel Fournier, L. T. Wang, D. Boutin, S. Moretti, B. Riemann, Michael Murray, Aleksandr Azatov, C. T. A. Cook, Valentina Maria Cairo, J. B. De Vivie De Regie, H. Schmickler, M. Schenk, Georgios Voutsinas, André Schöning, S. G. Bondarenko, Giorgio Bellomo, Andrei Seryi, Jane Nachtman, Clement Helsens, E. De Lucia, Jakob Salfeld-Nebgen, Lorenzo Pezzotti, Z. Townsend, B. Dalena, Mogens Dam, Yasar Onel, Yi-Ming Zhong, B. Curé, A. A. Kolomiets, A. M. Valente-Feliciano, Laurette Ponce, David Olivier Jamin, P. Krkotic, Alexandre Louzguiti, Marina Putti, Holger Podlech, Petr Volkov, M. Angelucci, F. Duval, I. Hiekkanen, W. M. Yao, Giancarlo Ferrera, C. Lorin, Y. Dydyshka, Kurt R. Peters, Gergely Gabor Barnafoldi, V. Vysotsky, V. Arı, E. Pilicer, M. Chamizo-Llatas, G. Kuhlmann, Hans Quack, R. Valizadeh, Tiina Salmi, Thomas Kramer, Adam Jeff, A. Abada, J. M. Duval, J. Abelleira Fernandez, A. Leveratto, E. Tal Hod, X. Wu, Laurent Serin, Sarah Aull, Samuele Mariotto, A. Poiron, Sabine Riemann, P. Selva, V. I. Pantsyrny, Gianluca Valentino, K. Kahle, S. Aune, K. Potamianos, Eros Cazzato, M. Giovannetti, Petr Mandrik, S. Sidorov, F. Collamati, Simone Gilardoni, S. Bertolucci, Alexander V. Zlobin, Mehmet Sahin, Marco Delmastro, G. Aydın, A. Doblhammer, Alan S. Cornell, S. J. De Jong, M. Caccia, M. Lueckhof, P. Sollander, Mauro Taborelli, J. Shelton, Frank Gerigk, Robert Rimmer, Ayres Freitas, Pierluigi Bruzzone, Brajesh K. Singh, K. Keppel, N. Alipour Tehrani, C. Prasse, Louis Rinolfi, Emma Slade, W. Flieger, Alexey Dudarev, H. J. Yang, T. Köttig, L. Mether, C. Weiland, Andrea Malagoli, Sunghoon Jung, F. Conventi, I. Tropin, G. H. A. Viehhauser, Tomas Davidek, Y. O. Günaydin, Daniel Andreas Britzger, F. Toral, James John Brooke, R. Steerenberg, G. Morello, Mauro Migliorati, Alexej Grudiev, C. Tetrel, Wolfgang Höfle, J. V. Minervini, L. García Tabarés, V. Yermolchik, Claude Guyot, D. Guadagnoli, Giorgio Vallone, N. De Filippis, Oleksii Beznosov, P. Charitos, N. Schwerg, Ahmed Hammad, P. Manil, F. Niccoli, Lydia Iconomidou-Fayard, R. Aleksan, K. Hahn, P. Meridiani, Peter Skands, Tobias Golling, Lucio Rossi, G. 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Han, Olivier Leroy, R. T. D’Agnolo, N. Klinkenberg, A. Audurier, Tatsushi Nakamoto, Ali Bozbey, Bernd A. Kniehl, Carl J. Debono, I. P. J. Shipsey, Gregorio Bernardi, Paolo Nason, William James Fawcett, J. M. Jiménez, D. Denisov, M. Serluca, David Curtin, Arif Akhundov, M. García Pérez, Iacopo Vivarelli, Emanuele Bacchiocchi, Markus Zerlauth, Julia Hrdinka, F. Butin, F. Müller, D. Tikhonov, Jorg Wenninger, A. Kilic, Fabrizio Ferro, J. Tanaka, S. A. Antipov, Miroslav Atanasov, S. Kuttimalai, A. Y. Starikov, F. R. Blánquez, S. V. Furuseth, G. Gaudio, L. Malgeri, J. Curti, B. Turbiarz, S. Li, A. Romanov, Costas G. Papadopoulos, Brennan Goddard, Frank Krauss, Lidija Zivkovic, Toms Torims, Michaela Lackner, D. A. Lyubimtsev, G. Borghello, J. F. Grosse-Oetringhaus, A. Bogomyagkov, H. Duran Yildiz, N. Foppiani, Arthur Schaffer, J. Zhou, D. Liberati, Vincenzo Guidi, Naeem A. Tahir, M. Besançon, Daniel Schoerling, Joe Incandela, Giacomo Polesello, O. Cakir, I. Ruehl, Ruggero Vaglio, Z. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y.W., Baglin V., Bai Y., Baird S., Baker M.J., Baldwin M.J., Ball A.H., Ballarino A., Banerjee S., Barber D.P., Barducci D., Barjhoux P., Barna D., Barnafoldi G.G., Barnes M.J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S.A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J.M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M.I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M.E., Biarrotte J.-L., Bibet Chevalier A., Bielert E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C.T.A., Cooley L., Corcella G., Cornell A.S., Corral G.H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J.F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R.T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S.P., DasBakshi S., da Silva W., da Silveira G.G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C.J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S.J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P.S.B., de Vivie de Regie J.B., Dewanjee R.K., Di Ciaccio A., Di Cicco A., Dillon B.M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi
Subjects: Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract: Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. 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ChattopadhyayR. ChehabS. V. ChekanovN. ChenA. ChernodedV. ChetvertkovaL. ChevalierG. ChiarelliG. ChiarelloM. ChiesaP. ChiggiatoJ. T. ChildersA. ChmielińskaA. CholakianP. ChomazM. ChorowskiW. ChouM. ChrzaszczE. ChyhyrynetsG. CibinettoA. K. CiftciR. CiftciR. CiminoM. CiuchiniP. J. ClarkY. CoadouM. CobalA. CoccaroJ. CoganE. CognerasF. CollamatiC. ColldelramP. CollierJ. CollotR. ContinoF. ConventiC. T. A. CookL. CooleyG. CorcellaA. S. CornellG. H. CorralH. Correia-RodriguesF. CostanzaP. Costa PintoF. CoudercJ. CoupardN. CraigI. Crespo GarridoA. CrivellinJ. F. CroteauM. CrouchE. Cruz AlanizB. CuréJ. CurtiD. CurtinM. CzechC. DachauerR. T. D’AgnoloM. DaiboA. DaineseB. DalenaA. DaljevecW. DallapiazzaL. D’Aloia SchwartzentruberM. DamG. D’AmbrosioS. P. DasS. DasBakshiW. da SilvaG. G. da SilveiraV. D’AuriaS. D’AuriaA. DavidT. DavidekA. DeandreaJ. de BlasC. J. DebonoS. De CurtisN. De FilippisD. de FlorianS. DeghayeS. J. de JongC. Del BoV. Del DucaD. DelikarisF. DeliotA. Dell’AcquaL. Delle RoseM. DelmastroE. De LuciaM. DemarteauD. DenegriL. DeniauD. DenisovH. DenizliA. DennerD. d’EnterriaG. de RijkA. De RoeckF. DerueO. DeschampsS. Descotes-GenonP. S. B. DevJ. B. de Vivie de RégieR. K. DewanjeeA. Di CiaccioA. Di CiccoB. M. DillonB. Di MiccoP. Di NezzaS. Di VitaA. DoblhammerA. DominjonM. D’OnofrioF. DordeiA. DragoP. DraperZ. DrasalM. DrewesL. DuarteI. DubovykP. DudaA. DudarevL. DudkoD. DuellmannM. DünserT. du PreeM. DuranteH. Duran YildizS. DuttaF. DuvalJ. M. DuvalY. DydyshkaB. DziewitS. EisenhardtM. EistererT. EkelofD. El KhechenS. A. EllisJ. EllisJ. A. EllisonK. ElsenerM. ElsingY. EnariC. EnglertH. ErikssonK. J. EskolaL. S. EspositoO. EtiskenE. EtzionP. FabbricatoreA. FalkowskiA. FalouJ. FaltovaJ. FanL. FanòA. FarillaR. FarinelliS. FarinonD. A. FaroughyS. D. FartoukhA. Faus-GolfeW. J. FawcettG. FeliciL. FelsbergerC. FerdeghiniA. M. Fernandez NavarroA. Fernández-TéllezJ. Ferradas TroitinoG. FerraraR. FerrariL. FerreiraP. Ferreira da SilvaG. FerreraF. FerroM. FiascarisS. FiorendiC. FiorioO. FischerE. FischerW. FliegerM. FlorioD. FonnesuE. FontanesiN. FoppianiK. ForazD. Forkel-WirthS. ForteM. FouaidyD. FournierT. FowlerJ. FoxP. FrancavillaR. FranceschiniS. FranchinoE. FrancoA. FreitasB. FuksK. FurukawaS. V. FurusethE. GabrielliA. GaddiM. GalantiE. GalloS. GanjourJ. GaoJ. GaoV. Garcia DiazM. García PérezL. García TabarésC. GarionM. V. GarzelliI. GarziaS. M. Gascon-ShotkinG. GaudioP. GayS. -F. GeT. GehrmannM. H. GenestR. GerardF. GerigkH. GerwigP. GiacomelliS. GiaguE. Gianfelice-WendtF. GianottiF. GiffoniS. S. GilardoniM. Gil CostaM. GiovannettiM. GiovannozziP. GiubellinoG. F. GiudiceA. GiuntaL. K. GladilinS. GlukhovJ. GluzaG. GobbiB. GoddardF. GoertzT. GollingV. P. GoncalvesR. GonçaloL. A. Gonzalez GomezS. Gorgi ZadehG. GorineE. GoriniS. A. GourlayL. GouskosF. GrancagnoloA. GrassellinoA. GrauE. GraveriniH. M. GrayMa. GrecoMi. GrecoJ. -L. GrenardO. GrimmC. GrojeanV. A. GromovJ. F. Grosse-OetringhausA. GrudievK. GrzankaJ. GuD. GuadagnoliV. GuidiS. GuiducciG. Guillermo CantonY. O. GünaydinR. GuptaR. S. GuptaJ. GutierrezJ. GutleberC. GuyotV. GuzeyC. GwenlanC. HaberstrohB. HacışahinoğluB. HaererK. HahnT. HahnA. HammadC. HanM. HanceA. HannahP. C. HarrisC. HatiS. HaugJ. HauptmanV. HaurylavetsH. -J. HeA. HegglinB. HegnerK. HeinemannS. HeinemeyerC. HelsensA. HenriquesA. HenriquesP. HernandezR. J. Hernández-PintoJ. Hernandez-SanchezT. HerzigI. HiekkanenW. HillertT. HoehnM. HoferW. HöfleF. HoldenerS. HolleisB. HolzerD. K. HongC. G. HonoratoS. C. HopkinsJ. HrdinkaF. HugB. HumannH. HumerT. HurthA. HuttonG. IacobucciN. IbarrolaL. Iconomidou-FayardK. Ilyina-BrunnerJ. IncandelaA. InfantinoV. IppolitoM. IshinoR. IslamH. ItaA. IvanovsS. IwamotoA. IyerS. Izquierdo BermudezS. JadachD. O. JaminP. JanotP. JarryA. JeffP. JennyE. JensenM. JensenX. JiangJ. M. JiménezM. A. JonesO. R. JonesJ. M. JowettS. JungW. KaabiM. KadoK. KahleL. KalinovskayaJ. KalinowskiJ. F. KamenikK. KannikeS. O. KaraH. KaradenizV. KaraventzasI. KarpovS. KartalA. KaryukhinV. 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MeoniP. MeridianiM. MerkP. MermodV. MertensL. MetherE. MétralM. MiglioratiA. MilaneseC. MilardiG. MilhanoB. L. MilitsynF. MilletI. MinashviliJ. V. MinerviniL. S. MirallesD. MirarchiS. MishimaD. P. MissiaenG. MitselmakherT. MitshuhashiJ. MnichM. Mohammadi NajafabadiR. N. MohapatraN. MokhovJ. G. MolsonR. MongeC. MontagG. MontagnaS. MonteilG. MonteneroE. MontesinosF. MoortgatN. MorangeG. MorelloM. Moreno LlácerM. MorettiS. MorettiA. K. MorleyA. MorosI. MorozovV. MorrettaM. MorroneA. MostacciS. MuanzaN. MuchnoiM. MühleggerM. MulderM. MuldersB. MüllerF. MüllerA. -S. MüllerJ. MunillaM. J. MurrayY. MuttoniS. MyersM. MylonaJ. NachtmanT. NakamotoM. NardecchiaG. NardiniP. NasonZ. NergizA. V. NesterenkoJ. A. NettoA. NettsträterC. NeubüserJ. NeundorfF. NiccoliO. NicrosiniY. NieU. NiedermayerJ. NiedzielaA. NiemiS. A. NikitinA. NisatiJ. M. NoM. NonisY. NosochkovM. NovákA. NovokhatskiJ. M. O’CallaghanC. OchandoS. OgurK. OhmiK. OideV. A. OkorokovY. OkumuraC. OleariF. I. OlnessY. OnelM. OrtinoJ. OsborneP. OslandT. OttoK. Y. OyulmazA. OzansoyV. ÖzcanK. ÖzdemirC. E. PagliaroneH. F. Pais da SilvaE. PalmieriL. PalumboA. PampaloniR. -Q. PanM. PanareoO. PanellaG. PanicoG. PanizzoA. A. PankovV. PantsyrnyC. G. PapadopoulosA. PapaefstathiouY. PapaphilippouM. A. ParkerV. ParmaM. PasqualiS. K. PatraR. PattersonH. PaukkunenF. PaussS. PeggsJ. -P. PenttinenG. PeónE. E. PerepelkinE. PerezJ. C. PerezG. PerezF. PérezE. Perez CodinaJ. Perez MoralesM. PerfilovH. PerneggerM. PeruzziC. PesK. PetersS. PetraccaF. PetrielloL. PezzottiS. PfeifferF. PiccininiT. PieloniM. PieriniH. PikhartovaG. PikursE. PilicerP. PiminovC. PiraR. PittauW. PłaczekM. PlaggeT. PlehnM. -A. PleierM. PłoskońM. PodeurH. PodlechT. PodzornyL. PoggioliA. PoironG. PoleselloM. Poli LenerA. PoliniJ. PolinskiS. M. PolozovL. PonceM. PontL. PontecorvoT. PortaluriK. PotamianosC. PrasseM. PrausaA. PreinerstorferE. PrematT. PriceM. PrimaveraF. PrinoM. PrioliJ. ProudfootA. ProvinoT. PugnatN. PukhaevaS. PuławskiD. PulikowskiG. PunziM. PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.
Published: 2020

36. Gastrointestinal pain

Author: Asbjørn M. Drewes, Anne E. Olesen, Adam D. Farmer, Eva Szigethy, Vinciane Rebours, and Søren S. Olesen
Subjects: General Medicine
Abstract: Gastrointestinal (GI) pain - a form of visceral pain - is common in some disorders, such as irritable bowel syndrome, Crohn's disease and pancreatitis. However, identifying the cause of GI pain frequently represents a diagnostic challenge as the clinical presentation is often blurred by concomitant autonomic and somatic symptoms. In addition, GI pain can be nociceptive, neuropathic and associated with cancer, but in many cases multiple aetiologies coexist in an individual patient. Mechanisms of GI pain are complex and include both peripheral and central sensitization and the involvement of the autonomic nervous system, which has a role in generating the symptoms that frequently accompany pain. Treatment of GI pain depends on the precise type of pain and the primary disorder in the patient but can include, for example, pharmacological therapy, cognitive behavioural therapies, invasive surgical procedures, endoscopic procedures and lifestyle alterations. Owing to the major differences between organ involvement, disease mechanisms and individual factors, treatment always needs to be personalized and some data suggest that phenotyping and subsequent individual management of GI pain might be options in the future.
Published: 2020

37. sj-pdf-1-ueg-10.1177_2050640620925968 - Supplemental material for Liraglutide accelerates colonic transit in people with type 1 diabetes and polyneuropathy: A randomised, double-blind, placebo-controlled trial

Author: Wegeberg, Anne-Marie Langmach, Hansen, Christian Stevns, Farmer, Adam D, Karmisholt, Jesper Scott, Asbjorn M Drewes, Jakobsen, Poul Erik, Brock, Birgitte, and Brock, Christina
Subjects: FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-pdf-1-ueg-10.1177_2050640620925968 for Liraglutide accelerates colonic transit in people with type 1 diabetes and polyneuropathy: A randomised, double-blind, placebo-controlled trial by Anne-Marie Langmach Wegeberg, Christian Stevns Hansen, Adam D Farmer, Jesper Scott Karmisholt, Asbjorn M Drewes, Poul Erik Jakobsen, Birgitte Brock and Christina Brock in United European Gastroenterology Journal
Published: 2020
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38. What is geriatric rehabilitation and how should it be organized?: A Delphi study aimed at reaching European consensus

Author: Jos M. G. A. Schols, Wilco P. Achterberg, Romke van Balen, Adam L. Gordon, Yvonne M. Drewes, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, RS: Academische Werkplaats Ouderenzorg, and Family Medicine
Subjects: Geriatric rehabilitation, Rehabilitation, business.industry, medicine.medical_treatment, Best practice, European consensus, Delphi method, Delphi procedure, CARE, Likert scale, 03 medical and health sciences, 0302 clinical medicine, Nursing, Multidisciplinary approach, medicine, MULTIDISCIPLINARY REHABILITATION, 030212 general & internal medicine, Cognitive decline, business, Inclusion (education), 030217 neurology & neurosurgery
Abstract: Purpose Many European countries have developed services to rehabilitate the increasing number of older people who experience an acute or subacute decrease in function after a medical event such as a hip fracture or stroke. However, there are important differences between countries regarding patient selection, organization of services, length of stay, and content of the rehabilitation process. The lack of consensus around, and quality criteria for, geriatric rehabilitation limits opportunities for exchange of best practice and scientific research. Methods 33 experts, mostly geriatricians with experience in geriatric rehabilitation, from 18 European countries were invited to participate in a modified Delphi study. They were asked to react to 68 statements using a five-point Likert scale. The statements were formulated on the basis of literature review and practice experience, and were initially piloted among Dutch elderly care physicians. Consensus was defined beforehand as an Interquartile Range (IQR) of Results Consensus was reached on 61 (90%) statements after two rounds. The resulting consensus covers: the need for a multidisciplinary approach to Geriatric Rehabilitation after CGA; inclusion of patients with temporary confusion or cognitive decline; use of structured goal-oriented rehabilitation plans; the necessity of an early start of rehabilitation; preference for ambulatory rehabilitation or Geriatric Rehabilitation at home; the advantage of protocolled treatment programs; the need for consensus on patient outcome assessment instruments; and education and training in Geriatric Rehabilitation for healthcare professionals. Conclusion These consensus statements provide a first step towards more coherent organization and delivery of geriatric rehabilitation across Europe.Key summary pointsAim To reach European Consensus on Geriatric Rehabilitation using a modified Delphi Procedure. Findings Consensus was reached on 61 statements on a broad range of topics. Message This consensus is important to facilitate exchange of best practice and compare results of scientific research.
Published: 2019

39. Pharmacological Management of Chronic Pain: How to Deal with the Catch-22 Situation

Author: Andresen, Trine, primary, Niesters, Marieke, additional, Dahan, Albert, additional, Morlion, Bart, additional, O´Brien, Tony, additional, and M. Drewes, Asbjørn, additional
Published: 2021
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40. Systematic Review of Guidelines on Antihypertensive Treatment in Older Adults: SPRINTing to More Heterogeneity?

Author: Sven Streit, Yvonne M. Drewes, Jonathan M. K. Bogaerts, Wilco P. Achterberg, Leonie M von Ballmoos, Milly A. van der Ploeg, Jacobijn Gussekloo, and Rosalinde K. E. Poortvliet
Subjects: Abstracts, Health (social science), Cardiovascular Health and Disease, Session 2899 (Poster), Life-span and Life-course Studies, AcademicSubjects/SOC02600, Health Professions (miscellaneous)
Abstract: Clinical trials have demonstrated that antihypertensive treatment (AHT) in older adults is beneficial. Longitudinal studies, in contrast, have shown that low blood pressure is associated with higher all-cause mortality, especially in frail older adults. Despite the high quality of the available evidence, its translation into clinical guidance for the heterogeneous older population is challenging. To give a systematic overview of blood pressure targets for older adults recommended in clinical guidelines, we searched PubMed, Embase, Emcare, and five guideline databases. We selected guidelines with numerical thresholds for the initiation or the goal of non-disease-specific AHT (January 2008-October 2019). Guidelines with advices concerning AHT in older adults were analyzed. We appraised the guideline quality with the AGREEII-instrument. Of the 44 guidelines containing a numerical threshold for the initiation or the goal of AHT, 33 (75%) provided recommendations concerning AHT for older adults. Nineteen advised a higher target of systolic blood pressure (SBP) for older adults in comparison with the middle-aged population and 3 more recent advised a lower target. Over half (19/33) recommended to treat hypertension in the oldest old to a SBP
Published: 2020

41. Incidental findings in research: A focus group study about the perspective of the research participant

Author: Yvonne M. Drewes, Ria Reis, Olaf M. Dekkers, Jeanet W. Blom, Renée de Mutsert, Martin den Heijer, Anna W de Boer, Mattijs E. Numans, Hildo J. Lamb, and Albert de Roos
Subjects: education.field_of_study, Truth Disclosure, business.industry, Population, Evidence-based medicine, Focus group, 03 medical and health sciences, 0302 clinical medicine, Informed consent, Research participant, Medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Thematic analysis, education, business, 030217 neurology & neurosurgery, Clinical psychology, Qualitative research
Abstract: Purpose To explore the experiences and preferences of population-based research participants to whom an incidental finding was communicated. Materials and Methods Of the 2580 participants of the Netherlands Epidemiology of Obesity (NEO) study who underwent magnetic resonance imaging (MRI) scanning of the abdomen, heart, and/or brain, an incidental finding with presumed health importance was disclosed to 56 (2%) participants. These participants were invited to discuss their experiences regarding the communication of the finding by the NEO research team in a focus group discussion. Transcripts of the discussions were analyzed using thematic content analysis with an open coding system. Results Twenty-three persons participated in four discussions: 57% male; mean age 58 years; 74% findings were suspect for a malignancy. Overall, the participants were grateful for the disclosure of the incidental finding. They had assumed that any finding would be disclosed, and this was an important reason to participate in research. None regretted their informed consent to be notified about incidental findings. Disclosure of the finding had great impact on the lives of most participants. Difficulties with the transition from research participant to patient were frequently mentioned. Conclusion This study provides information to improve the communication of incidental findings by 1) giving clear information about which findings will be disclosed, and 2) demarcating the transition from research participant to patient, by making clear arrangements with medical specialists to guarantee careful follow-up of the finding. Level of Evidence: 3 J. Magn. Reson. Imaging 2017.
Published: 2017

42. Gastrointestinal pain

Author: Asbjørn M, Drewes, Anne E, Olesen, Adam D, Farmer, Eva, Szigethy, Vinciane, Rebours, and Søren S, Olesen
Subjects: Gastrointestinal Tract, Adaptation, Psychological, Humans, Pain
Abstract: Gastrointestinal (GI) pain - a form of visceral pain - is common in some disorders, such as irritable bowel syndrome, Crohn's disease and pancreatitis. However, identifying the cause of GI pain frequently represents a diagnostic challenge as the clinical presentation is often blurred by concomitant autonomic and somatic symptoms. In addition, GI pain can be nociceptive, neuropathic and associated with cancer, but in many cases multiple aetiologies coexist in an individual patient. Mechanisms of GI pain are complex and include both peripheral and central sensitization and the involvement of the autonomic nervous system, which has a role in generating the symptoms that frequently accompany pain. Treatment of GI pain depends on the precise type of pain and the primary disorder in the patient but can include, for example, pharmacological therapy, cognitive behavioural therapies, invasive surgical procedures, endoscopic procedures and lifestyle alterations. Owing to the major differences between organ involvement, disease mechanisms and individual factors, treatment always needs to be personalized and some data suggest that phenotyping and subsequent individual management of GI pain might be options in the future.
Published: 2019

43. Recommendations for (Discontinuation of) Statin Treatment in Older Adults: Review of Guidelines

Author: Jonathan M. K. Bogaerts, Carmen Floriani, Milly A. van der Ploeg, Rosalinde K. E. Poortvliet, Yvonne M. Drewes, Sven Streit, Jacobijn Gussekloo, Wilco P. Achterberg, and Simon P. Mooijaart
Subjects: Male, medicine.medical_specialty, Statin, medicine.drug_class, Population, Context (language use), 610 Medicine & health, Review Article, 030204 cardiovascular system & hematology, clinical decision making, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, prevention, 360 Social problems & social services, Medicine, Humans, 030212 general & internal medicine, Intensive care medicine, education, Review Articles, Aged, Expectancy theory, Aged, 80 and over, education.field_of_study, business.industry, hydroxymethylglutaryl‐CoA reductase inhibitors, Age Factors, Guideline, Discontinuation, cardiovascular diseases, drug therapy, Withholding Treatment, Practice Guidelines as Topic, Female, Geriatrics and Gerontology, Deprescribing, business, hydroxymethylglutaryl-CoA reductase inhibitors
Abstract: Objectives As a person's age increases and his/her health status declines, new challenges arise that may lead physicians to consider deprescribing statins. We aimed to provide insight into recommendations available in international cardiovascular disease prevention guidelines regarding discontinuation of statin treatment applicable to older adults. Design We systematically searched PubMed, EMBASE, EMCARE, and the websites of guideline development organizations and online guideline repositories for cardiovascular disease prevention guidelines aimed at the general population. We selected all guidelines with recommendations (instructions and suggestions) on discontinuation of statin treatment applicable to older adults, published between January 2009 and April 2019. In addition, we performed a synthesis of information from all other recommendations for older adults regarding statin treatment. Methodological quality of the included guidelines was appraised using the appraisal of guidelines for research & evaluation II (AGREE II) instrument. Results Eighteen international guidelines for cardiovascular disease prevention in the general adult population provided recommendations for statin discontinuation that were applicable to older adults. We identified three groups of instructions for statin discontinuation related to statin intolerance, and none was specifically aimed at older adults. Three guidelines also included suggestions to consider statin discontinuation in patients with poor health status. Of the 18 guidelines included, 16 made recommendations regarding statin treatment in older adults, although details on how to implement these recommendations in practice were not provided. Conclusion Current international cardiovascular disease prevention guidelines provide little specific guidance for physicians who are considering statin discontinuation in older adults in the context of declining health status and short life expectancy. J Am Geriatr Soc 68:417-425, 2020.
Published: 2019

44. What is geriatric rehabilitation and how should it be organized? A Delphi study aimed at reaching European consensus

Author: Romke, van Balen, Adam L, Gordon, Jos M G A, Schols, Yvonne M, Drewes, and Wilco P, Achterberg
Abstract: Many European countries have developed services to rehabilitate the increasing number of older people who experience an acute or subacute decrease in function after a medical event such as a hip fracture or stroke. However, there are important differences between countries regarding patient selection, organization of services, length of stay, and content of the rehabilitation process. The lack of consensus around, and quality criteria for, geriatric rehabilitation limits opportunities for exchange of best practice and scientific research.33 experts, mostly geriatricians with experience in geriatric rehabilitation, from 18 European countries were invited to participate in a modified Delphi study. They were asked to react to 68 statements using a five-point Likert scale. The statements were formulated on the basis of literature review and practice experience, and were initially piloted among Dutch elderly care physicians. Consensus was defined beforehand as an Interquartile Range (IQR) of /= 1 for each statement.Consensus was reached on 61 (90%) statements after two rounds. The resulting consensus covers: the need for a multidisciplinary approach to Geriatric Rehabilitation after CGA; inclusion of patients with temporary confusion or cognitive decline; use of structured goal-oriented rehabilitation plans; the necessity of an early start of rehabilitation; preference for ambulatory rehabilitation or Geriatric Rehabilitation at home; the advantage of protocolled treatment programs; the need for consensus on patient outcome assessment instruments; and education and training in Geriatric Rehabilitation for healthcare professionals.These consensus statements provide a first step towards more coherent organization and delivery of geriatric rehabilitation across Europe.
Published: 2019

45. Correction: Predictors of opioid efficacy in patients with chronic pain: A prospective multicenter observational cohort study

Author: Kasper Grosen, Anne E. Olesen, Mikkel Gram, Torsten Jonsson, Michael Kamp-Jensen, Trine Andresen, Christian Nielsen, Gorazd Pozlep, Mogens Pfeiffer-Jensen, Bart Morlion, and Asbjørn M. Drewes
Subjects: Multidisciplinary, Science, Medicine
Abstract: [This corrects the article DOI: 10.1371/journal.pone.0171723.].
Published: 2019

46. Assessment of Appropriateness of Cardiovascular Preventive Medication in Adults ≥ 75 years

Author: Jacobijn Gussekloo, Rosalinde K. E. Poortvliet, Milly A. van der Ploeg, and Yvonne M. Drewes
Subjects: Session 3023 (Paper), Abstracts, medicine.medical_specialty, Health (social science), business.industry, Preventive medication, Emergency medicine, medicine, AcademicSubjects/SOC02600, Life-span and Life-course Studies, business, Health Professions (miscellaneous), Cardiovascular Health and Disease (paper)
Abstract: Physicians are confronted with dilemma’s on cardiovascular preventive medication for older people with complex health problems. With accumulation of diseases, limitations and shortening life expectancy, questions arise for whom cardiovascular preventive treatment is still appropriate (the expected benefits of treatment exceeds the negative consequences by a sufficiently wide margin resulting that treatment is worth doing). There is a need for more guidance in clinical situations. With the RAND/UCLA appropriateness method (RUAM), we investigated the appropriateness of cardiovascular preventive medication in adults ≥ 75 years. The RUAM is a systematic, formalized method, to combine available scientific evidence with the collective judgment of experts. Fourteen interdisciplinary panelists (9 physicians representing 6 medical disciplines, 1 medical ethics expert, 1 pharmacist and 3 older adults [lay man]), discussed and rated the appropriateness of starting and stopping of three medication groups (cholesterol lowering, blood pressure lowering and thrombocyte aggregation inhibitors) for different clinical scenarios (combinations of cardiovascular history, systolic blood pressure, complexity of health problems, age, life-expectancy, side-effects). Depending on the medication group, different patterns of appropriateness judgments across the clinical scenarios were found. In general, absence of cardiovascular disease, presence of complex health problems, a short life-expectancy or hindering side-effects were important factors to judge cardiovascular preventive medication as inappropriate. Results were summarized into colored reading maps. These findings can offer more guidance in clinical decision making about cardiovascular preventive treatment for adults ≥ 75 years.
Published: 2020

47. MRI analysis of fecal volume and dryness: Validation study using an experimental oxycodone-induced constipation model

Author: Esben B, Mark, Mark B, Bødker, Debbie, Grønlund, Lasse R, Østergaard, Jens B, Frøkjaer, and Asbjørn M, Drewes
Subjects: Adult, Male, Cross-Over Studies, Colon, Reproducibility of Results, Middle Aged, Magnetic Resonance Imaging, Analgesics, Opioid, Feces, Young Adult, Double-Blind Method, Humans, Female, Prospective Studies, Constipation, Oxycodone
Abstract: Opioids are known to affect gastrointestinal motility, but their effect on fluid absorption and secretion is poorly understood in humans.To investigate the effect of oxycodone on colonic fecal volume and stool dryness by using a novel MRI-based technique.Prospective, randomized, double-blinded, crossover study.Twenty-five healthy male volunteers (median age: 24 years [range: 21-56]; mean body mass index [BMI]: 23.9 kg/mTSubjects were treated for 5 days with prolonged-release oxycodone or a placebo. Imaging was performed on the first and last study day in each period. Images of the colon were analyzed with semiautomatic k-means-based segmentation software. Regional colonic fecal volumes were quantified excluding gas volume and colon wall. Two-point Dixon and TIntraclass correlation coefficients were used to test the reliability of measurements between days, while repeated measures mixed models were applied to test treatment effects.After oxycodone treatment, total colonic fecal volume was significantly increased compared with placebo (mean change 100 mL vs. -13 mL; P = 0.001), with the largest increase (24%) observed in the ascending colon/cecum (P = 0.001). Dixon signal increased (less water in colon content) after oxycodone treatment compared with placebo (mean 0.09 vs. -0.02; P0.001). TThe 5-day oxycodone treatment increased colonic fecal volume and increased stool dryness compared with placebo. This imaging-based method for noninvasive analysis of colon content has the potential to characterize gastrointestinal symptoms in general, such as in constipation.2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:733-745.
Published: 2018

48. Alkaline Paper Versus Acidic Paper in Current Publishing: A Preliminary Analysis

Author: Jeanne M. Drewes
Published: 2018

49. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis

Author: W B van den Hout, René J. F. Melis, Nienke Bleijenberg, A. P. D. Jansen, Isabelle Fabbricotti, M. E. Muntinga, W.P.J. den Elzen, E. P. Moll van Charante, Raymond T.C.M. Koopmans, Silke F. Metzelthin, Franca G. H. Ruikes, Jacobijn Gussekloo, Sophie L. W. Spoorenberg, Jacqueline J. Suijker, Mattijs E. Numans, Klaske Wynia, N.J. de Wit, Gertrudis I. J. M. Kempen, Theo Stijnen, Jeanet W. Blom, Wilhelmina Mijntje Looman, Yvonne M. Drewes, A. W. Wind, ACS - Diabetes & metabolism, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, General practice, Health Services Management & Organisation (HSMO), Health Technology Assessment (HTA), RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Ethics, Law & Medical humanities, APH - Aging & Later Life, and APH - Societal Participation & Health
Subjects: Gerontology, Aging, Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], Activities of daily living, Cost effectiveness, Psychological intervention, Subgroup analysis, ELDERLY-PEOPLE, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], older people, 03 medical and health sciences, InformationSystems_GENERAL, primary care, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Quality of life (healthcare), Multidisciplinary approach, Health care, PROGRAM, Medicine, 030212 general & internal medicine, INDEX, SCALE, FUNCTIONAL DECLINE, integrated care, general practice, old people, business.industry, 030503 health policy & services, General Medicine, ADULTS, 610 Medical sciences, RANDOMIZED CONTROLLED-TRIAL, EXPERIENCES, Integrated care, MODEL, aged, ddc: 610, Geriatrics and Gerontology, 0305 other medical science, business, Research Paper, INTERVENTIONS
Abstract: Background: Supporting older people with several healthcare needs in sustaining adequate functioning and independence puts a major challenge on the healthcare system. Proactive approaches are needed. Objectice: This study summarizes the (cost-)effectiveness of eight proactive, multidisciplinary,[for full text, please go to the a.m. URL], 51. Kongress für Allgemeinmedizin und Familienmedizin
Published: 2018

50. Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer

Author: Klaus Krogh, Søren Laurberg, Peter Christensen, P.M. Faaborg, Christina Brock, Lilli Lundby, Anbjørn M. Drewes, Mikkel Gram, and S Haas
Subjects: Male, Gastrointestinal Diseases, medicine.medical_treatment, Cortical processing, Anal Canal, Gastroenterology, 0302 clinical medicine, Hematology, Anal canal, Middle Aged, Anus Neoplasms, medicine.anatomical_structure, Oncology, Reaction Time/physiology, Sensory Thresholds, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, medicine.medical_specialty, Gastrointestinal Diseases/physiopathology, Afferent Pathways/physiopathology, Sensation, Rectum, Anus Neoplasms/physiopathology, Sensory system, Proctopathy, Sensation/radiation effects, Sensory Thresholds/physiology, Catheterization, 03 medical and health sciences, Physical Stimulation, Internal medicine, Rectum/physiopathology, Reaction Time, medicine, Pressure, Anal cancer, Humans, Radiology, Nuclear Medicine and imaging, In patient, Relative amplitude, Ano-rectal sensitivity, Afferent Pathways, business.industry, Fecal Incontinence/physiopathology, medicine.disease, Anal Canal/innervation, Radiation therapy, Physical Stimulation/methods, Case-Control Studies, Single sweep, business, Fecal Incontinence
Abstract: INTRODUCTION: Sphincter-sparing radiotherapy or chemoradiation (RT/CRT) have become the standard treatments for most patients with anal cancer. Unfortunately, long-term survivors often suffer from severe bowel symptoms indicating sensory dysfunction. The aim of the present study was to characterize the sensory pathways of the brain-gut axis after radiotherapy for anal cancer.METHOD: Cortical evoked potentials (CEPs) were recorded during repeated, rapid balloon distensions of the rectum and anal canal in 13 patients with anal cancer treated with radiotherapy or chemoradiation and in 17 healthy volunteers. Latencies and amplitudes of rectal CEPs were compared between the groups. CEPs from both rectal and anal distensions were examined using single sweep spectral band analysis to determine the relative amplitude of five spectral bands as a proxy of neuronal processing.RESULTS: Groups were comparable by age (62.4 ± 7.8 vs 58.9 ± 8.9, p CONCLUSION: Patients treated with RT/CRT for anal cancer have impaired ano-rectal sensory pathways and abnormal cortical processing. This may play a central role for the pathogenesis of late proctopathy.
Published: 2018

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