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Synovial sarcoma (SS) is a soft tissue tumor that occurs among a group of tumors other than rhabdomyosarcoma (RMS) in childhood and adolescence in 4 % of cases. In terms of incidence among children, SS is second only to RMS and most often occurs in young and mature patients (15–35 years), with a slight predominance in men. The localization of SS in the soft tissues of the extremities reaches 80 %; to a lesser extent, these tumors occur in the head and neck, trunk, retroperitoneal space, and joints (no more than 5 %). Cases of the appearance of SS in the mediastinum, peripheral nerves, skin and visceral organs are also described.This article presents a rare clinical case of the development of SS of the median nerve of the right shoulder in a 15-year-old patient.

В статье описана апробированная социальная технология «Эффективная социализация детей в образовательном комплексе», автором которой является старший научный сотрудник Института социологии РАН Н.П. Гришаева. Технология состоит в том, что дети могут в течение одного часа свободно перемещаться по ДОУ, заходить в гости в кабинеты педагогов, в любые группы, музыкальный и физкультурный залы, где им будут предложены увлекательные занятия и игры. Через час по звуковому сигналу ребята возвращаются в свои группы.

Статья посвящена принципиально новым динамическим моделям взаимодействия организаций в условиях академической мобильности системы высшего образования, раскрыта суть образовательной программы академической мобильности «с локальной и с широкой свободой». Авторы акцентируют внимание на том, что в проектировании предлагаемых динамических моделей важное значение имеет переход от классических образовательных программ к реализации индивидуальных образовательных траекторий обучающихся, к формированию междисциплинарной, межвузовской образовательной среды, способствующей развитию талантливой молодежи и раскрытию потенциала молодых исследователей, а также обеспечиваются равные права получения образования обучающимся с особыми образовательными потребностями и особенностями развития.

Статья посвящена актуальной теме – внедрению и развитию цифровых и информационных технологий, инноваций в страховой отрасли в России. Проведен мониторинг практики использования цифровизации в сфере страхования и выполнен анализ динамики и структуры страховых премий по договорам страхования, заключенным через интернет. Также выделены основные направления развития цифровизации в данной отрасли на ближайшее время.

Results of ELISA investigation of the pretreatment sPD-1 and sPD-L1 content in blood serum of 133 bone neoplasms patients aged 6-70 years and 57 practically healthy control persons aged 12-70 years are described. In 14 patients the neoplasms were of a benign character, in 16 - borderline giant-cell bone tumor was diagnosed, and in 103 - malignant bone lesions including 39 osteosarcomas and 42 chondrosarcomas were revealed. The sPD-1 receptor concentrations in blood serum did not differ between control healthy persons and primary bone tumor patients, while serum sPD-L1 level in bone tumor patients was statistically significantly increased (p

The levels of sPD-1 and sPD-L1 were analyzed in blood serum of 132 patients (age 14-70 years) with primary bone tumors: osteosarcoma (N=39), chondrosarcoma (N=42), Ewing sarcoma (N=9), chordoma (N=12), giant-cell bone tumor (GCBT) (N=16), benign neoplasms (N=14) and in and practically healthy subjects (age 19-58 years; N=27). sPD-L1 levels in all studied bone neoplasms were significantly higher than in the control. Serum sPD-1 level in GCBT patients was significantly higher than in the control, benign neoplasms, chondrosarcoma, and chordoma patients, but did not differ from osteosarcoma group. sPD-1 concentration in Ewing sarcoma was significantly higher than in chordoma and chondrosarcoma, but did not differ from the control. sPD-1 level in chondrosarcoma patients was also lower than in osteosarcoma, Ewing sarcoma, and in the control. Both sPD-1 and sPD-L1 concentrations were not significantly associated with the type of affected bone, process localization, disease stage, tumor histological grade, patients' age and sex. These results suggest the possibility of using these biological markers for preliminary assessment of the character of the process in the bone.

“Asian values” as a concept appeared in the socio-political discourse in 1990s due to the so-called Rise of Asia. Major political leaders of Malaysia and Singapore, Mahathir Mohamad and Lee Kuan Y., played a special role in their conceptual design. The discourse “Asian values” provoked a strong reaction in scientific and political circles around the world, the debates on them are still continuing. The main question regarding “Asian values” is how to determine the degree and nature of their influence on the development of the countries of the East. The purpose of this study is to identify different approaches to the assessment of this concept, the reasons for their occurrence, as well as the role and place of “Asian values” in the process of modernization in the East. As a result, it was revealed that the political situation in the region brought about the development of the concept. Owing to the struggle of a number of states for their influence on the Southeast Asian countries, the latter turned to “Asian values” as ideological sources of self-identification. Another reason is the fact that this concept allows to take into account specific ways of modernization in each country. Finally, the concept was adopted as an ideological basis for the integration process in ASEAN, which remains one of the most progressive integration associations in the Asia-Pacific region. Thus, today, the concept of “Asian values” not only proved its viability, but also became an occasion for development of similar ideas in other regions of the world. Acknowledgements. The article was prepared in the framework of the project no. 19-011-31053 “Megatrends of World Politics in the 21st Century: Spheres of Manifestation and Development” with financial support from RFBR and EISR.

Results of ELISA investigation of the pretreatment sPD-1 and sPD-L1 content in blood serum of 133 bone neoplasms patients aged 6-70 years and 57 practically healthy control persons aged 12-70 years are described. In 14 patients the neoplasms were of a benign character, in 16 - borderline giant-cell bone tumor was diagnosed, and in 103 - malignant bone lesions including 39 osteosarcomas and 42 chondrosarcomas were revealed. The sPD-1 receptor concentrations in blood serum did not differ between control healthy persons and primary bone tumor patients, while serum sPD-L1 level in bone tumor patients was statistically significantly increased (p0.0000001). By means of ROC curve construction a cut-off sPD-L1 level of 16.5 pg/ml was found that imposed 75,9% sensitivity and 75,4% specificity in relation to healthy control. However, the frequency of sPD-L1 levels exceeding 16.5 pg/ml was approximately similar in benign, borderline and malignant bone tumor patients. Analysis of the pattern of sPD-1 and sPD-L1 circulation in the peripheral blood of patients with the most prevalent malignant bone tumors - osteosarcoma and chondrosarcoma - demonstrated that in both sarcoma types sPD-L1 level was significantly higher than in control, but in patients with chondrogenic tumors the soluble ligand sPD-L1 dominates in the circulation, while in those with osteogenic tumors - sPD-1 receptor prevails. In particular, sPD-1 level is statistically significantly higher in patients with typical osteosarcoma than in those with typical chondrosarcoma (p=0.002437), and sPD-L1/sPD-1 concentration ratio in chondrosarcoma is highly significantly more than 2-fold higher than in osteosarcoma (0.81 and 0.35 respectively; p=0.000284). The sensitivity of sPD-L1 ≥16.5 pg/ml test in typical osteosarcoma patients' group comprised only 70.2%, and in those with typical chondrosarcoma - 84.6%. Serum sPD-1 and sPD-L1 concentrations in osteosarcoma and chondrosarcoma patients were not associated with the indices of tumor advancement, its histological grade, localization in the osseous system, and type of affected bone. Thus, it can be concluded that the ratio between circulating soluble forms of the receptor and the ligand of PD-1/PD-L signaling pathway differs between patients with chondrogenic and those with osteogenic tumors, sPD-L1 being diagnostically valuable mostly for chondrogenic bone neoplasms.

Recently, the concept of Islam Nusantara appeared in the Islamic social thought of Indonesia. This term was officially put into circulation by the religious and educational organization Nahdatul Ulama (Revival of the Ulema) in 2015. Islam Nusantara respects cultural and religious differences as manifestations of the will of Allah, believes that love and compassion are integral features of the Muslim religion. Islam Nusantara organically does not accept the authoritarian and pretending to be the truth in the last instance interpretations of Islam, imposed by extremists. Islam Nusantara is the reinterpretation of the basic theological principles of the NU, which combines classical Islamic theology (aqeedah), jurisprudence (fiqh) and local traditions. This approach suggests that Indonesian Muslims do not need to give up their national and local identity. On the contrary, traditional values can coexist harmoniously with Islamic identity, and an orthodox Muslim can simultaneously be an Indonesian nationalist. Supporters of the concept emphasize that this is not some new trend in Islamic social thought or another interpretation of Islam. Islam Nusantara is an Indonesian version of Muslim religious practice, historically developed in the process of its dissemination on the archipelago. Islam Nusantara provokes sharp rejection and condemnation of representatives of radical Muslim movements, especially Wahhabism and Salafism and their like, who seek to purify Islam from local traditions.

Aim. To determine echocardiographic profiles and their prognostic value using factor analysis in men and women with various types of cardiomyopathies (CMP).Material and methods. The study involved 100 people with CMP — 69 men with a median age of 53 years and 31 women with a median age of 58 years. Among the subjects, six nosological types corresponding to ICD 10 classification were revealed: dilated CMP (DCM), ischemic CMP (ICM), alcoholic CMP, mixed CMP, hypertrophic CMP (HCM) and myocarditis. All persons underwent an echocardiography. Echocardiography results as variables were included in factor analysis. The resulting two factors are presented as the first and second echocardiographic profiles.Results. The first echocardiographic profile was characterized as the degree of myocardial contractile function reduction. A strong association of the first profile with DCM, alcoholic CMP and myocarditis in men (p=0,001) and DCM in women (p=0,05) was obtained. In some individuals with ICM and mixed CMP, there was no association with the first profile. The second echocardiographic profile reflected the degree of myocardial mass increase and had significant differences only in women (p=0,04). A strong correlation with the second profile was observed in HCM, in the majority of women with ICM and in some persons with mixed CMP. Fatal outcomes in men were recorded in patients with ICM (66,7%), alcoholic CMP and myocarditis, and in women with mixed CMP (11,1%).Conclusion. For patients with DCM, myocarditis, and alcoholic CMP, the first echocardiographic profile with a risk of death is characteristic. The second echocardiographic profile was inherent in HCM and was associated with a protective effect in women with ICM. The revealed echocardiographic profiles can be extrapolated to nosological types of CMP in men and women in order to verify the diagnosis and prognosis.

The influence of impurities on the solid-solution hardening of cold-rolled low-carbon steel components is considered, by calculation and experiment. To confirm the results, data regarding the influence of the chemical composition on the properties of cold-rolled 08Ю steel components (produced by Cherepovets Metallurgical Works, OAO Severstal’) are subjected to statistical analysis, with the formulation of a regression model. The factors that underlie the influence of impurities on the properties of 08Ю steel are investigated, and the optimal impurity contents for products of the highest extrusion category are established.

Independent methods of geological and molecular-biological chronologies have made it possible to define generally corresponding stages in the geological and biological evolution of the environments and communities of Lake Baikal since the Late Cretaceous, i.e., during the last 70 myr. All the abiotic elements drastically changed during geological evolution, with destruction of existing and formation of new natural complexes. Nevertheless, some specific zones retained relicts of former settings. The resulting present-day natural complex includes elements of different ages and geneses. Similar to different natural zones of the present-day Earth, which are populated by different biocoenoses, stages in the development of abiotic elements are also characterized by different faunal and floral assemblages. Some taxa were replaced by others, and the resulting aqueous biota of Lake Baikal includes different-age and ecologically different elements. The oldest groups of Baikal organisms appeared approximately 70 Ma ago, although the largest proportion of the lake biota started forming 4–3 Ma ago in response to the most drastic changes in the abiotic elements of the environment. The youngest taxa appeared 1.8 to 0.15 Ma ago, i.e., during the period when superdeep lake environments and mountainous glaciations were developing. The chronological coincidence of main stages in development of abiotic and biotic elements of the nature indicates their relationships. Particular transformations of abiotic elements and the probable mechanism of their influence on the evolution of living communities are also considered.

Precision hobs with small pitch angles and small module are of single-turn form and are as large in diameter as possible. Such hobs are used to manufacture high-precision gears with a small number z of teeth [1]. This is because, with increase in the number of turns, the increasing speed of the tooth-cutting table leads to rapid wear of the worm pair. Therefore, if the minimum number of gear teeth to be cut should be z min = 10 according to the machine tool’s ratings, this number should be k times larger when using a multiturn hob (with k turns). Thus, z min = 20 for a two-turn hob, 30 for a three-turn hob, and so on. It is expedient to cut gears with a large number of teeth ( z min ≥ 100) by means of multiturn hobs, in order to increase the productivity. In addition, as shown by the calculations, it is impossible to precisely adjust the division frame in some cases with the existing set of replaceable gears, when a single-turn hob is employed. The solution here is either to use two- or three-turn hobs (with corresponding loss of gear precision) or to manufacture additional replaceable gears for the frames.

In several experimental techniques D2O rather then H2O is often used as a solvent for proteins. Concerning the influence of the solvent on the stability of the proteins, contradicting results have been reported in literature. In this paper the influence of H2O-D2O solvent substitution on the stability of globular protein structure is determined in a systematic way. The differential scanning calorimetry technique is applied to allow for a thermodynamic analysis of two types of globular proteins: hen's egg lysozyme (LSZ) with relatively strong internal cohesion ("hard" globular protein) and bovine serum albumin (BSA), which is known for its conformational adaptability ("soft" globular protein). Both proteins tend to be more stable in D2O compared to H2O. We explain the increase of protein stability in D2O by the observation than D2O is a poorer solvent for nonpolar amino acids than H2O, implying that the hydrophobic effect is larger in D2O. In case of BSA the transitions between different isomeric forms, at low pH values the Nm and F forms, and at higher pH values Nm and B, were observed by the presence of a supplementary peak in the DSC thermogram. It appears that the pH-range for which the Nm form is the preferred one is wider in D2O than in H2O. (c) Wiley Periodicals, Inc.

Recommendations have been developed on optimizing hot rolling in the finishing train of a 2000 mill and subsequent coiling of the rolled product. The goal was to improve the stampability characteristics of steel 08Yu. Specific recommendations were also made on the optimum annealing and temper-rolling regimes to improve the mechanical characteristics of steel 08Yu. The results of studies show that the structure and properties of the cold-rolled product are significantly affected by the conditions of precipitation of different particles of nonmetallic inclusions. It is shown that it would be expedient to analyze the thermodynamics and kinetics of these processes and study the morphology of the particles and the state of the solid solution. Recommendations on chemical composition and process parameters that were developed on the basis of the results of such analysis are now making it possible to consistently obtain steel 08Yu with high properties.

Results are presented from a study of dual phase ferritic-martensitic steels (DFMS) of two compositions: 0.08% C, 1.18% Si, 1.81% Mn, and 0.39% Cr; 0.07% C, 1.16% Si, 1.79% Mn, 0.40% Cr, and 0.14% V. In order to obtain different structural parameters in the two DFMS, heat treatments were given to 3.2-mm-thick specimens of steel sheet with different initial structures: the ferrite-pearlite-bainite mixture obtained directly from hot rolling; a ferrite matrix with spheroidized carbides, obtained by heating the hot-rolled sheet and holding it at 1050°C for 1 h, cooling the sheet with the furnace to 690°C, holding the sheet at this temperature for 15 h, and then further cooling the sheet together with the furnace. The results confirmed the positive effect of “new” ferrite on the ductility of DFMS. This effect is connected not with the intrinsic properties of new ferrite but with the factors that help increase the initial volume of this component in the steel (the amount of new ferrite in the investigated steels ranges up to 20–25%).

One of the main trends in the development of materials for the body and other parts of automobiles is the greater use of high-strength steels, this being done in order to make the vehicle safer and lighter. The need for this change stems from the continual tightening of standards on tailpipe emissions. The largest metallurgical companies that presently make automobile sheet have been working with the main Russian automobile manufacturers to develop steels with improved commercial properties. This article presents results from studies conducted to optimize the technology used to make rolled products of high-strength, ultralow-carbon steels 01YuTB an 01YuPTB for the automotive industry. The optimized technology includes heat treatment in a continuous annealing furnace. Emphasis should be given to developing technical recommendations on how to optimally combine strength, stampability, and a guaranteed level of the BH-effect (BH2 ≥ 30–40 N/mm2) in the production of automobile sheet of strength class K180, as well as BH steels of strength class K220 or higher.

Bovine serum albumin (BSA) and lysozyme (LSZ) were radiolabeled with 125I. Three different methods for protein iodination with 125I were optimized. Parameters like incubation time and ratio of oxidizing agent and amount of protein were established. During protein iodination with 125I, structural damages caused by the introduction of iodine into the protein may occur. These damages depend on the oxidizing agent used and may lead to considerable changes in the protein structure and, hence, their biological activity. Changes in secondary structure of LSZ and BSA were examined by circular dichroism (CD). Enzymatic activity tests were performed with lysozyme to check its biological activity. The Iodo Bead was found the best oxidizing agent for protein iodination.

As Indonesia was becoming independent after the Second World War, the Communist Party of Indonesia (CPI, or PKI in its Indonesian initials) came to play far less of a role in the country's politics...

The characteristic time scale of adsorption has an important contribution to the history of adsorbed protein layers. Control over this time scale is achieved by designing a measuring cell with well-defined laminar liquid flow in parallel plate geometry to be used on a neutron reflectometer. Results obtained from adsorption experiments with lysozyme clearly show that there is an effect of adsorption time scales on the properties of adsorbed layers.

The structure of the protein layers adsorbed at different interfaces can be determined by using neutron-reflection and small-angle neutron scattering. For highlighting the adsorbed protein layer at the interface, the technique of contrast-variation by changing the H 2 O/D 2 O ratio, is often used. For determining the scattering length density, both the protein volume in solution and the total scattering length of the protein is needed. The volume is calculated from the amino-acid sequence. For calculating the scattering length, the H/D exchange of the labile protons of the protein should be taken into account. For monitoring the H/D exchange, Positive Electrospray Ionization Mass Spectroscopy was applied. We compare experimental results for the exchange in lysozyme and β -casein with theoretical calculations. The importance of using the correct protein scattering-length density is elucidated by simultaneous model fitting to neutron reflection data at different water contrasts.

Depuis l'echec de la tentative de coup d'Etat de 1965 en Indonesie, un nouveau systeme politique est ne; il se nomme democratie Pancasila. Cela signifie qu'en realite, ce sont les autorites officielles qui ont donne le coup d'envoi d'un reveil religieux islamique. Au depart, on trouve la volonte des elites dirigeantes de combattre ses rivaux politiques islamiques, de maintenir le systeme politique existant autoritaire par essence. Cette elite dirigeante recherche l'identite nationale indonesienne dans les traditions politico-religieuses archaiques

An actinomyceteous strain LIA-0185 producing a heptaenic non-aromatic antibiotic of the candidin type was isolated from a soil sample taken in the Georgian SSR under the programme of screening antifungal antibiotics. The taxonomic study of the strain showed that it belonged to the series of viridoflavum and had the following main taxonomic features: the sporophores in the whorls, straight, remote: the aerial mycelium from yellow to dark-olive-grey; the substrate mycelium olive; the soluble pigment absent; the melanine pigment was produced on the peptone medium; the culture formed H2S; assimilated glucose, mannose, inozide and to a lesser extent fructose; did not assimilate arabinose, xylose, sucrose, lactose, ramnose and raffinose. The strain inhibited the growth of yeast and fungi, grampositive bacteria and actinomycetes and produced a complex of non-aromatic heptaenic antibiotics. The actinomycete differed from the other whorl cultures. It was classified as a new species Sv. griseoviridum sp. nov. The antibiotic complex was a mixture of 2 components, i. e. I and II present approximately in equal amounts. Component II was analogous to candidin. Component I was a new original substance.