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Introduction. Human papillomavirus (HPV), its highly oncogenic types, is considered to be the initiating factor in the development of dysplasia and cervical cancer The role of immunomodulatory therapy in reducing the risk of cervical cancer in women with cervical intraepithelial neoplasia (CIN) associated with HPV infection remains in the focus of researchers. Aim of the study: to evaluate the effectiveness of the use of the immunomodulator Allokin-alfa in the complex treatment of cervical intraepithelial neoplasia against the background of genital papillomavirus infection. Materials and methods. We examined 60 women who received CIN1- 2 treatment on the background of HPV infection of high oncogenic risk in the multidisciplinary medical center of the Odessa National Medical University. The patients were divided into 2 groups: 1 (main) group consisted of 30 women who received cold plasma ablation of cervical dysplasia in combination with immunomodulatory therapy with alloferon, group 2 (comparison) consisted of 30 patients who received standard cold plasma ablative treatment without immunomodulators. The control group consisted of 30 healthy women. All women underwent cytomorphological examination of the cervical epithelium, HPV testing, colposcopy, and targeted biopsy. Immunological status was assessed by indicators of cellular and humoral immunity, the content of α- and γ-interferon. Results. In patients with CIN1-2 against the background of HPV, an increase in the level of serum Ig A, CD8 level, a decrease in the CD4 content and immunoregulatory index, CD19 content were revealed, which indicated immunosuppression. Immunocorrective therapy witn alloferon (Allokin-alfa) in complex, with cold plasma ablation, treatment of CIN1-2 promoted the normalization of the parameters of immunity and interferon status, which contributed to the acceleration of epithelialization, (OR — 15,48; 95% CІ: 2,05-136,45; р=0,0094). a decrease in the frequency of residual lesions, and a HPV elimination. Conclusions. Complex treatment of CIN1-2 using cold plasma ablation and immunocorrection by perioperative administration of alloferon (Allokin-alfa) is accompanied by better functional results, compared only with the use of cold plasma ablation: accelerated epithelialization, improved colposcopic picture, decreased frequency of relapses, elimination of HPV, normalization of immunе and interferon status.

For plane deformations generated by an arbitrary distribution of tractions applied in a small region on the boundary of an elastic half-plane, the rates-of-decay for displacements, stresses and strain energy density are obtained as functions of complexity of the load distribution. The rates-of-decay increase in proportion to the complexity of the load distribution; i.e., they increase with the order of the smallest nonvanishing moment of the traction distribution. In orthotropic materials the elastic moduli differ in two perpendicular directions of principal stiffness; in this case as the modulus ratio E 2 / E 1 {E_2}/{E_1} increases, the angular distributions of the displacement and energy density fields become channeled towards the direction of the larger elastic modulus.

A self-equilibrated system of forces acting in a small region of an elastic solid results in a strain energy density that decreases rapidly as the distance from the loaded region increases. If the set of forces is in astatic equilibrium, the strain energy density decreases more rapidly than if the forces are merely self-equilibrated. For an anisotropic solid, there is a small rate-of-decrease of strain energy density in the direction where Young's modulus is the largest. The effect of anisotropy on the distribution of radial displacements is much more exagerated in the direction where the modulus is large than is the case for stress or strain energy density. These results are pertinent to applications of Saint-Venant's principle in the case of anisotropic solids; e.g. structures made from a unidirectional fibrous composite.

The expressions for the strain energy release rate associated with local delaminations growing from the tips of angle ply matrix cracks in orthotropic laminates loaded in tension are presented. Strain energy release rate and the laminate residual stiffness properties are predicted as functions of matrix crack density and delamination length.