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1. OMICS AND PROGNSTIC MARKERS

Author

K. Adachi, H. Sasaki, S. Nagahisa, K. Yoshida, N. Hattori, Y. Nishiyama, T. Kawase, M. Hasegawa, M. Abe, Y. Hirose, A. Alentorn, Y. Marie, S. Poggioli, H. Alshehhi, B. Boisselier, C. Carpentier, K. Mokhtari, L. Capelle, D. Figarella-Branger, K. Hoang-Xuan, M. Sanson, J.-Y. Delattre, A. Idbaih, S. Yust-Katz, M. Anderson, A. Olar, A. Eterovic, N. Ezzeddine, K. Chen, H. Zhao, G. Fuller, K. Aldape, J. de Groot, N. Andor, J. Harness, S. G. Lopez, T. L. Fung, H. W. Mewes, C. Petritsch, A. Arivazhagan, K. Somasundaram, K. Thennarasu, P. Pandey, B. Anandh, V. Santosh, B. Chandramouli, A. Hegde, P. Kondaiah, M. Rao, R. Bell, R. Kang, C. Hong, J. Song, J. Costello, R. Nagarajan, B. Zhang, A. Diaz, T. Wang, L. Bie, Y. Li, H. Liu, W. F. C. Luyo, M. H. Carnero, M. E. P. Iruegas, A. R. Morell, M. C. Figueiras, R. L. Lopez, C. F. Valverde, A. K.-Y. Chan, J. C.-S. Pang, N. Y.-F. Chung, K. K.-W. Li, W. S. Poon, D. T.-M. Chan, Y. Wang, H.-a. K. Ng, M. Chaumeil, P. Larson, H. Yoshihara, D. Vigneron, S. Nelson, R. Pieper, J. Phillips, S. Ronen, V. Clark, Z. E. Omay, A. Serin, J. Gunel, B. Omay, C. Grady, M. Youngblood, K. Bilguvar, J. Baehring, J. Piepmeier, P. Gutin, A. Vortmeyer, C. Brennan, M. N. Pamir, T. Kilic, B. Krischek, M. Simon, K. Yasuno, M. Gunel, A. L. Cohen, M. Sato, K. D. Aldape, C. Mason, K. Diefes, L. Heathcock, L. Abegglen, D. Shrieve, W. Couldwell, J. D. Schiffman, H. Colman, Q. G. D'Alessandris, T. Cenci, M. Martini, L. Ricci-Vitiani, R. De Maria, L. M. Larocca, R. Pallini, B. Theeler, F. Lang, G. Rao, M. Gilbert, E. Sulman, R. Luthra, K. Eterovic, M. Routbort, R. Verhaak, G. Mills, J. Mendelsohn, F. Meric-Bernstam, A. Yung, K. MacArthur, S. Hahn, G. Kao, R. Lustig, M. Alonso-Basanta, S. Chandrasekaran, E. P. Wileyto, E. Reyes, J. Dorsey, K. Fujii, K. Kurozumi, T. Ichikawa, M. Onishi, J. Ishida, Y. Shimazu, B. Kaur, E. A. Chiocca, I. Date, C. Geisenberger, A. Mock, R. Warta, C. Schwager, C. Hartmann, A. von Deimling, A. Abdollahi, C. Herold-Mende, O. Gevaert, A. Achrol, S. Gholamin, S. Mitra, E. Westbroek, J. Loya, L. Mitchell, S. Chang, G. Steinberg, S. Plevritis, S. Cheshier, J. Xu, S. Napel, G. Zaharchuk, G. Harsh, D. Gutman, C. Holder, R. Colen, W. Dunn, R. Jain, L. Cooper, S. Hwang, A. Flanders, D. Brat, J. Hayes, A. Droop, H. Thygesen, M. Boissinot, D. Westhead, S. Short, S. Lawler, P. Bady, S. Kurscheid, M. Delorenzi, M. E. Hegi, C. Crosby, C. Faulkner, T. Smye-Rumsby, K. Kurian, M. Williams, K. Hopkins, A. Palmer, H. Williams, C. Wragg, H. R. Haynes, K. M. Kurian, P. White, T. Oka, L. Jalbert, A. Elkhaled, R. Jensen, K. Salzman, M. Schabel, D. Gillespie, M. Mumert, B. Johnson, T. Mazor, M. Barnes, S. Yamamoto, H. Ueda, K. Tatsuno, K. Aihara, A. Bollen, M. Hirst, M. Marra, A. Mukasa, N. Saito, H. Aburatani, M. Berger, B. Taylor, S. Popov, A. Mackay, W. Ingram, A. Burford, A. Jury, M. Vinci, C. Jones, D. T. W. Jones, V. Hovestadt, S. Picelli, W. Wang, P. A. Northcott, M. Kool, G. Reifenberger, T. Pietsch, M. Sultan, H. Lehrach, M.-L. Yaspo, A. Borkhardt, P. Landgraf, R. Eils, A. Korshunov, M. Zapatka, B. Radlwimmer, S. M. Pfister, P. Lichter, A. Joy, I. Smirnov, M. Reiser, W. Shapiro, S. Kim, B. Feuerstein, C. Jungk, S. Friauf, A. Unterberg, T. A. Juratli, J. McElroy, W. Meng, A. Huebner, K. D. Geiger, D. Krex, G. Schackert, A. Chakravarti, T. Lautenschlaeger, B. Y. Kim, W. Jiang, J. Beiko, S. Prabhu, F. DeMonte, R. Sawaya, D. Cahill, I. McCutcheon, C. Lau, L. Wang, K. Terashima, S. Yamaguchi, M. Burstein, J. Sun, T. Suzuki, R. Nishikawa, H. Nakamura, A. Natsume, S. Terasaka, H.-K. Ng, D. Muzny, R. Gibbs, D. Wheeler, X.-q. Zhang, S. Sun, K.-f. Lam, K. M. Y. Kiang, J. K. S. Pu, A. S. W. Ho, G. K. K. Leung, F. Loebel, W. T. Curry, F. G. Barker, N. Lelic, A. S. Chi, D. P. Cahill, D. Lu, J. Yin, C. Teo, K. McDonald, A. Madhankumar, C. Weston, B. Slagle-Webb, J. Sheehan, A. Patel, M. Glantz, J. Connor, C. Maire, J. Francis, C.-Z. Zhang, J. Jung, V. Manzo, V. Adalsteinsson, H. Homer, B. Blumenstiel, C. S. Pedamallu, E. Nickerson, A. Ligon, C. Love, M. Meyerson, K. Ligon, L. E. Jalbert, S. J. Nelson, A. W. Bollen, I. V. Smirnov, J. S. Song, A. B. Olshen, M. S. Berger, S. M. Chang, B. S. Taylor, J. F. Costello, S. Mehta, B. Armstrong, S. Peng, A. Bapat, M. Berens, B. Melendez, M. Mollejo, P. Mur, T. Hernandez-Iglesias, C. Fiano, J. Ruiz, J. A. Rey, V. Stadler, A. Schulte, K. Lamszus, C. Schichor, M. Westphal, J.-C. Tonn, O. Morozova, S. Katzman, M. Grifford, S. Salama, D. Haussler, A. Olshen, S. Fouse, S. Nakamizo, T. Sasayama, H. Tanaka, K. Tanaka, K. Mizukawa, M. Yoshida, E. Kohmura, P. Northcott, D. Jones, S. Pfister, R. Otani, S. Takayanagi, K. Saito, S. Tanaka, M. Shin, T. Ozawa, M. Riester, Y.-K. Cheng, J. Huse, K. Helmy, N. Charles, M. Squatrito, F. Michor, E. Holland, M. Perrech, L. Dreher, G. Rohn, R. Goldbrunner, M. Timmer, B. Pollo, V. Palumbo, C. Calatozzolo, M. Patane, R. Nunziata, M. Farinotti, A. Silvani, S. Lodrini, G. Finocchiaro, E. Lopez, A. Rioscovian, R. Ruiz, G. Siordia, A. P. de Leon, C. Rostomily, R. Rostomily, D. Silbergeld, D. Kolstoe, M. Chamberlain, J. Silber, P. Roth, A. Keller, J. Hoheisel, P. Codo, A. Bauer, C. Backes, P. Leidinger, E. Meese, E. Thiel, A. Korfel, M. Weller, G. Nagae, M. Nagane, J. Z. Sanborn, T. Mikkelsen, S. Jhanwar, L. Chin, M. Nishihara, M. Schliesser, C. Grimm, E. Weiss, R. Claus, D. Weichenhan, M. Weiler, T. Hielscher, F. Sahm, B. Wiestler, A.-C. Klein, J. Blaes, C. Plass, W. Wick, G. Stragliotto, A. Rahbar, C. Soderberg-Naucler, M. Won, R. Ezhilarasan, P. Sun, D. Blumenthal, M. Vogelbaum, R. Jenkins, R. Jeraj, P. Brown, K. Jaeckle, D. Schiff, J. Dignam, J. Atkins, D. Brachman, M. Werner-Wasik, M. Mehta, J. Shen, J. Luan, A. Yu, M. Matsutani, Y. Liang, T.-K. Man, A. Trister, M. Tokita, S. Mikheeva, A. Mikheev, S. Friend, M. van den Bent, L. Erdem, T. Gorlia, M. Taphoorn, J. Kros, P. Wesseling, H. Dubbink, A. Ibdaih, P. French, H. van Thuijl, J. Heimans, B. Ylstra, J. Reijneveld, A. Prabowo, I. Scheinin, H. van Essen, W. Spliet, C. Ferrier, P. van Rijen, T. Veersema, M. Thom, A. S.-v. Meeteren, E. Aronica, H. Kim, S. Zheng, D. J. Brat, S. Virk, S. Amini, C. Sougnez, J. Barnholtz-Sloan, R. G. W. Verhaak, C. Watts, A. Sottoriva, I. Spiteri, S. Piccirillo, A. Touloumis, P. Collins, J. Marioni, C. Curtis, S. Tavare, B. Tews, T. P. C. Yeung, B. Al-Khazraji, L. Morrison, L. Hoffman, D. Jackson, T.-Y. Lee, S. Yartsev, G. Bauman, J. Fu, R. Vegesna, Y. Mao, L. E. Heathcock, W. Torres-Garcia, S. Wang, A. McKenna, C. W. Brennan, W. K. A. Yung, J. N. Weinstein, E. P. Sulman, and D. Koul

Subjects
Abstracts, Cancer Research, Text mining, Oncology, business.industry, Neurology (clinical), Computational biology, Biology, Omics, business
Published
2013
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2. PEDIATRICS LABORATORY RESEARCH

Author

M. S. Brassesco, E. T. Valera, J. A. Pezuk, A. G. Morales, J. C. Oliveira, K. Umezawa, E. M. Rego, G. C. Carlotti, C. A. Scrideli, L. G. Tone, J.-i. Adachi, T. Suzuki, T. Yanagisawa, K. Fukuoka, K. Mishima, K. Wakiya, M. Matsutani, R. Nishikawa, A. Fernandez-L, M. Squatrito, P. Northcott, E. C. Holland, M. D. Taylor, Z. Nahle, A. M. Kenney, D. M. Ashley, A. Muscat, L. Gordon, L. Rigby, D. Birks, N. Foreman, E. Algar, L. K. Donovan, N. Potter, T. Warr, G. Pilkington, A. Erdreich-Epstein, H. Zhou, X. Ren, T. B. Davidson, M. Schur, L. Ji, R. Sposto, S. Asgharzadeh, L. Hiddingh, V. Caretti, E. Hulleman, G.-J. L. Kaspers, W. P. Vandertop, D. P. Noske, T. Wurdinger, T. Lagerweij, P. W. Koken, G. G. Kaspers, E. E. Bar, K. Schreck, C. G. Eberhart, D. A. Largaespada, J. D. Larson, F. J. Rodriquez, A. M. Demer, A. L. Sarver, A. Dubuc, R. B. Jenkins, A. J. Dupuy, N. G. Copeland, N. A. Jenkins, M. A. Taylor, M. Monje, M. E. Freret, P. A. Beachy, M. H. Jansen, P. W. Vandertop, K. Dorris, M. Sobo, E. Panditharatna, C. Liu, M.-O. Kim, L. Miles, S. Goldman, S. Gardner, C. Stevenson, T. Maugans, M. Fouladi, R. Drissi, D. W. Fults, M. Mumert, C. A. Pedone, X. Wu, P. A. Northcott, A. M. Saratsis, S. Magge, B. Rood, A. Hill, J. Nazarian, D. G. van Vuurden, M. Bugiani, P. Wesseling, G. J. Kaspers, V. Gopalakrishnan, C. Das, M. Gireud, P. Taylor, A. Singh, D. Lee, K. Aldape, G. Fuller, J. Fangusaro, V. Rajaram, and C. Eberhart

Subjects
Cancer Research, business.industry, Rhabdoid tumors, Clinical neurology, Abstracts, Oncology, Cancer research, Etiology, Medicine, Profiling (information science), Neurology (clinical), Epigenetics, SMARCB1, business
Published
2011
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3. Single and Multiple Dose Pharmacokinetics of a Pharmaceutical Compound in Elderly Subjects

Author

D. Smallwood, J. Burton, F. Cattelin, R. Van Horn, Juan Shi, D. Wu, G. Lockwood, J. Newton, P. Price, M. Drozd, H. Jang, B. Joshi, M. Mumert, G. Wei, J. Mosser, and D. Buhrman

Subjects
business.industry, Public Health, Environmental and Occupational Health, Cmax, Pharmacology (nursing), Urine, Pharmacology, Multiple dosing, Multiple dose, Partial agonist, Pharmacokinetics, Drug Guides, Blood plasma, Medicine, Pharmacology (medical), business, Clearance
Abstract

Single and multiple dose pharmacokinetics of a pharmaceutical compound (Compound A) have been assessed in blood, plasma, and urine from healthy elderly volunteers. Subjects were assigned to one of three treatment groups with 10 subjects/group. All three groups received a single dose of sesquifumarate salt (Compound Aa) of Compound A on Period 1; Groups I and II received a 5 mg dose and Group III received a 10 mg dose. In Period 2, Group I subjects received 5 mg b.i.d.; Group II subjects received 5 mg t.i.d., and Group III subjects received 10 mg b.i.d. Multiple dose treatment was given for seven days and Periods 1 and 2 were separated by at least seven days. Both blood (WB) and plasma (PL) concentrations were determined using LC-MS/MS. Both assays had a limit of quantitation of 0.1 ng/mL. Urine concentrations were determined with a LC-MS/MS assay having a limit of quantitation of 25 ng/mL. The AUC (0 → 24) and Cmax of Compound A increased proportionally after single and multiple doses in both matrices. Steady state was reached before the first dose on Day 7. The accumulation was well predicted across three treatment groups in both matrices. For each b.i.d. group, the average exposure to Compound A after morning dose on Day 7 was increased by approximately two-fold from Day 1. These results demonstrate that Cmax and AUC values for Compound A increased in a dose proportional fashion and that the accumulation of Compound A can be predicted based on single dose pharmacokinetics. No apparent effect of dose regimens upon the renal clearance was observed. There was also no significant difference demonstrated for the renal clearance of Compound A between single dose (Day 1) and multiple dose (Day 7). Approximately 4–7% of dose was recovered in urine as unchanged drug (Compound A).

Published
1997
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4. Functional genomics identifies drivers of medulloblastoma dissemination.

Author

Mumert M, Dubuc A, Wu X, Northcott PA, Chin SS, Pedone CA, Taylor MD, and Fults DW

Subjects
Animals, Cell Line, Cerebellar Neoplasms metabolism, Cyclin-Dependent Kinases genetics, Cyclin-Dependent Kinases metabolism, DNA Transposable Elements genetics, Female, Hedgehog Proteins genetics, Hedgehog Proteins metabolism, Humans, Immunohistochemistry, Intermediate Filament Proteins genetics, Intermediate Filament Proteins metabolism, LIM-Homeodomain Proteins genetics, LIM-Homeodomain Proteins metabolism, Male, Medulloblastoma metabolism, Meninges metabolism, Meninges pathology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Mutagenesis, Insertional, Neoplasm Metastasis, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, Nestin, Oligonucleotide Array Sequence Analysis, Oncogene Protein p21(ras) genetics, Oncogene Protein p21(ras) metabolism, Spinal Cord metabolism, Spinal Cord pathology, Transcription Factors genetics, Transcription Factors metabolism, Cyclin-Dependent Kinase-Activating Kinase, Cerebellar Neoplasms genetics, Gene Expression Profiling methods, Genomics methods, Medulloblastoma genetics
Abstract

Medulloblastomas are malignant brain tumors that arise in the cerebellum in children and disseminate via the cerebrospinal fluid to the leptomeningeal spaces of the brain and spinal cord. Challenged by the poor prognosis for patients with metastatic dissemination, pediatric oncologists have developed aggressive treatment protocols, combining surgery, craniospinal radiation, and high-dose chemotherapy, that often cause disabling neurotoxic effects in long-term survivors. Insights into the genetic control of medulloblastoma dissemination have come from transposon insertion mutagenesis studies. Mobilizing the Sleeping Beauty transposon in cerebellar neural progenitor cells caused widespread dissemination of typically nonmetastatic medulloblastomas in Patched(+/-) mice, in which Shh signaling is hyperactive. Candidate metastasis genes were identified by sequencing the insertion sites and then mapping these sequences back to the mouse genome. To determine whether genes located at transposon insertion sites directly caused medulloblastomas to disseminate, we overexpressed candidate genes in Nestin(+) neural progenitors in the cerebella of mice by retroviral transfer in combination with Shh. We show here that ectopic expression of Eras, Lhx1, Ccrk, and Akt shifted the in vivo growth characteristics of Shh-induced medulloblastomas from a localized pattern to a disseminated pattern in which tumor cells seeded the leptomeningeal spaces of the brain and spinal cord., (©2012 AACR.)

Published
2012
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