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4 results on '"M. Orcesi"'

1. Synthesis, structure, and biological activity of organotion compounds with Di-2-pyridylketone and phenyl(2-pyridyl) ketone 2-aminobenzoylhydrazones

Author

Corrado Pelizzi, P. Mazza, Sandra Ianelli, M. Orcesi, Franca Zani, and Giancarlo Pelizzi

Subjects
Models, Molecular, Magnetic Resonance Spectroscopy, Ketone, Infrared Rays, Pyridines, Stereochemistry, Microbial Sensitivity Tests, Crystal structure, Bacillus subtilis, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Inorganic Chemistry, Anti-Infective Agents, Organotin Compounds, medicine, chemistry.chemical_classification, Bacteria, Molecular Structure, biology, Mutagenicity Tests, Chemistry, Ligand, Spectrum Analysis, Fungi, Hydrazones, Hydrogen Bonding, Biological activity, Ketones, biology.organism_classification, Anti-Bacterial Agents, Genotoxicity
Abstract

The ligand behavior of di-2-pyridylketone 2-aminobenzoylhydrazone (Hdpa), and phenyl(2-pyridyl)ketone 2-aminobenzoylhydrazone (Hdpa) towards organotin derivatives was investigated. The synthesis and the IR and 119Sn NMR spectroscopic characterization of the compounds is reported, together with the X-ray crystal structures of Hdpa and Sn(C6H5)3Cl(OH2)·Hdpa, which are discussed and compared. The in vitro evaluation of antimicrobial properties revealed the strong activity of Sn(C6H5)2(Hdpa)Cl2 and Sn(C6H5)3Cl(OH2)·Hdpa complexes. None of the compounds showed genotoxicity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.

Published
1995
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2. Synthesis, structure, antimicrobial, and genotoxic activities of organotin compounds with 2,6-diacetylpyridine nicotinoyl- and isonicotinoylhydrazones

Author

M. Orcesi, P. Mazza, Giancarlo Pelizzi, Franca Zani, Giovanni Predieri, and Corrado Pelizzi

Subjects
Nicotine, Spectrophotometry, Infrared, Pyridines, Stereochemistry, Ionic bonding, Infrared spectroscopy, Crystal structure, Biochemistry, Medicinal chemistry, Chemical synthesis, Ames test, Inorganic Chemistry, Pentagonal bipyramidal molecular geometry, X-Ray Diffraction, Salmonella, Organotin Compounds, Molecule, Bacteria, Molecular Structure, Mutagenicity Tests, Chemistry, Fungi, Hydrazones, DNA, Trigonal bipyramidal molecular geometry, DNA Damage
Abstract

A series of organotin compounds obtained from the reaction of 2,6-diacetylpyridine nicotinoyl- and isonicotinoylhydrazones with tri- and diorganotin chlorides was investigated. The IR and 119Sn NMR spectroscopic characterization of all the compounds is reported, together with the x-ray crystal structure of [SnEt2(H2dapin')]2[SnEt2Cl3]Cl3 · 2H2O (H2dapin'= 2,6-diacetylpyridine bis(isonicotinoylhydrazone)). The main feature in this compound is the presence of a tin atom in both the complex ionic units. The coordination polyhedron is a pentagonal bipyramid in the cation and a trigonal bipyramid in the anion. Results are discussed concerning the in vitro evaluation of antimicrobial properties and genotoxic potential of the compounds described. In all cases the complexes show a reduced antimicrobial activity as compared to that of the corresponding organotin compound. Genotoxic properties of the ligands, detected in the Ames test, disappear in the complexes.

Published
1992
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3. Synthesis, structure, and biological activity of organotin compounds with di-2-pyridylketone and phenyl(2-pyridyl) ketone 2-aminobenzoylhydrazones.

Author

Ianelli S, Mazza P, Orcesi M, Pelizzi C, Pelizzi G, and Zani F

Subjects
Anti-Bacterial Agents, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Bacteria drug effects, Crystallography, X-Ray, Fungi drug effects, Hydrazones chemistry, Hydrogen Bonding, Infrared Rays, Ketones chemistry, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Mutagenicity Tests, Organotin Compounds pharmacology, Pyridines chemistry, Spectrum Analysis, Organotin Compounds chemical synthesis, Organotin Compounds chemistry
Abstract

The ligand behavior of di-2-pyridylketone 2-aminobenzoylhydrazone (Hdpa), and phenyl(2-pyridyl)ketone 2-aminobenzoylhydrazone (Hdba) towards organotin derivatives was investigated. The synthesis and the IR and 119Sn NMR spectroscopic characterization of the compounds is reported, together with the X-ray crystal structures of Hdpa and Sn(C6H5)3Cl(OH2).Hdpa, which are discussed and compared. The in vitro evaluation of antimicrobial properties revealed the strong activity of Sn(C6H5)2(Hdpa)Cl2 and Sn(C6H5)3Cl(OH2).Hdpa complexes. None of the compounds showed genotoxicity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.

Published
1995
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4. Synthesis, structure, antimicrobial, and genotoxic activities of organotin compounds with 2,6-diacetylpyridine nicotinoyl- and isonicotinoylhydrazones.

Author

Mazza P, Orcesi M, Pelizzi C, Pelizzi G, Predieri G, and Zani F

Subjects
DNA Damage, Hydrazones chemistry, Molecular Structure, Mutagenicity Tests, Nicotine chemistry, Organotin Compounds chemistry, Pyridines chemistry, Salmonella drug effects, Salmonella genetics, Spectrophotometry, Infrared, X-Ray Diffraction, Bacteria drug effects, DNA drug effects, Fungi drug effects, Organotin Compounds chemical synthesis, Organotin Compounds pharmacology
Abstract

A series of organotin compounds obtained from the reaction of 2,6-diacetylpyridine nicotinoyl- and isonicotinoylhydrazones with tri- and diorganotin chlorides was investigated. The IR and 119Sn NMR spectroscopic characterization of all the compounds is reported, together with the x-ray crystal structure of [SnEt2(H2dapin')]2[SnEt2Cl3]Cl3.2H2O (H2dapin' = 2,6-diacetylpyridine bis(isonicotinoylhydrazone)). The main feature in this compound is the presence of a tin atom in both the complex ionic units. The coordination polyhedron is a pentagonal bipyramid in the cation and a trigonal bipyramid in the anion. Results are discussed concerning the in vitro evaluation of antimicrobial properties and genotoxic potential of the compounds described. In all cases the complexes show a reduced antimicrobial activity as compared to that of the corresponding organotin compound. Genotoxic properties of the ligands, detected in the Ames test, disappear in the complexes.

Published
1992
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