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5 results on '"M. P. J. Polak"'

1. Diagnostic performance of axillary ultrasound and standard breast MRI for differentiation between limited and advanced axillary nodal disease in clinically node-positive breast cancer patients

Author

S. Samiei, H. C. van Beek, T. J. A. van Nijnatten, A. J. G. Maaskant-Braat, Marjolein L. Smidt, Robert-Jan Schipper, Marc B. I. Lobbes, S.M.J. van Kuijk, M. P. J. Polak, Esther M. Heuts, Promovendi ODB, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA BV AIOS Radiologie (9), Surgery, MUMC+: MA Heelkunde (9), MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: MA AIOS Heelkunde (9), Beeldvorming, and MUMC+: DA BV Medisch Specialisten Radiologie (9)

Subjects
MULTICENTER, lcsh:Medicine, PREOPERATIVE ULTRASONOGRAPHY, Surgical planning, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Surgical oncology, Breast MRI, lcsh:Science, DISSECTION, Lymph node, Ultrasonography, Observer Variation, Multidisciplinary, medicine.diagnostic_test, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Outcomes research, 030220 oncology & carcinogenesis, Lymphatic Metastasis, BIOPSY, Radiographic Image Interpretation, Computer-Assisted, Female, Lymph, Radiology, SENTINEL-NODE, Adult, medicine.medical_specialty, Breast Neoplasms, Sensitivity and Specificity, Article, Diagnosis, Differential, 03 medical and health sciences, Breast cancer, medicine, Humans, RECONSTRUCTION, Aged, FINE-NEEDLE-ASPIRATION, LYMPH-NODES, business.industry, lcsh:R, Axillary Lymph Node Dissection, medicine.disease, FDG-PET/CT, METASTASIS, Axilla, Lymph Node Excision, lcsh:Q, Histopathology, business
Abstract

Preoperative differentiation between limited (pN1; 1–3 axillary metastases) and advanced (pN2–3; ≥4 axillary metastases) nodal disease can provide relevant information regarding surgical planning and guiding adjuvant radiation therapy. The aim was to evaluate the diagnostic performance of preoperative axillary ultrasound (US) and breast MRI for differentiation between pN1 and pN2–3 in clinically node-positive breast cancer. A total of 49 patients were included with axillary metastasis confirmed by US-guided tissue sampling. All had undergone breast MRI between 2008–2014 and subsequent axillary lymph node dissection. Unenhanced T2-weighted MRI exams were reviewed by two radiologists independently. Each lymph node on the MRI exams was scored using a confidence scale (0–4) and compared with histopathology. Diagnostic performance parameters were calculated for differentiation between pN1 and pN2–3. Interobserver agreement was determined using Cohen’s kappa coefficient. At final histopathology, 67.3% (33/49) and 32.7% (16/49) of patients were pN1 and pN2–3, respectively. Breast MRI was comparable to US in terms of accuracy (MRI reader 1 vs US, 71.4% vs 69.4%, p = 0.99; MRI reader 2 vs US, 73.5% vs 69.4%, p = 0.77). In the case of 1–3 suspicious lymph nodes, pN2–3 was observed in 30.4% on US (positive predictive value (PPV) 69.6%) and in 22.2–24.3% on MRI (PPV 75.7–77.8%). In the case of ≥4 suspicious lymph nodes, pN1 was observed in 33.3% on US (negative predictive value (NPV) 66.7%) and in 38.5–41.7% on MRI (NPV 58.3–61.5%). Interobserver agreement was considered good (k = 0.73). In clinically node-positive patients, the diagnostic performance of axillary US and breast MRI is comparable and limited for accurate differentiation between pN1 and pN2–3. Therefore, there seems no added clinical value of preoperative breast MRI regarding nodal staging in patients with positive axillary US.

Published
2019

2. Anterior Cruciate Ligament Regeneration in an 8-Year-Old Patient

Author

S. J. Arts, Rob P.A. Janssen, and M. P. J. Polak

Subjects
medicine.medical_specialty, medicine.diagnostic_test, musculoskeletal, neural, and ocular physiology, Anterior cruciate ligament, Regeneration (biology), Magnetic resonance imaging, Physical examination, musculoskeletal system, Brace, Surgery, Conservative treatment, Acl rupture, surgical procedures, operative, medicine.anatomical_structure, medicine, Physical exam, human activities
Abstract

Ruptured anterior cruciate ligaments (ACL) have doubtful healing potential. This might be better in younger patients. Therefore, treatment of an ACL rupture in the skeletally immature patient knows several strategies. We report the case of an 8-year-old, skeletally immature patient with a midsubstance-ruptured ACL at physical exam and magnetic resonance imaging (MRI). Conservative treatment with a brace led to a stable knee with regeneration of the ACL on both the physical examination and MRI after 5 years. Nevertheless, further research will be necessary to gain better understanding about the biology and healing potential of the ACL.

Published
2015

3. Standard breast MRI for improved differentiation between limited and advanced axillary nodal disease in breast cancer patients

Author

H. C. van Beek, Esther M. Heuts, Marjolein L. Smidt, M. Lobbes, Robert J Schipper, S. Maaskant, M. P. J. Polak, Sanaz Samiei, and T. J. A. van Nijnatten

Subjects
Cancer Research, medicine.medical_specialty, Breast cancer, Oncology, medicine.diagnostic_test, business.industry, medicine, Breast MRI, Radiology, business, medicine.disease, Nodal disease
Published
2018

4. Abstracts of papers and posters Pharmacological Meeting

Author

J. M. J. Lamers, M. Krikke, E. M. Hessel, M. B. Vroom, H. J. M. G. Nelissen-Vrancken, J. H. P. Wilson, B. C. P. Hüsken, A. D. Kraneveld, A. J. Hoogstraate, B. J. A. Janssen, J. P. C. de Bruin, X. Y. Du, R.J. van der Geest, R. G. Schoemaker, M. P. J. Polak, A. E. Bottone, M.C. van den Tweel, M. J. Smit, A. Sj. Koster, A. J. M. Van Oosterhout, J. C. Visser, A. F. M. Janssen, Frans G. M. Russel, P. J. Gaillard, F. H. M. Derkx, H. Meurs, Henk Van Loveren, S. Y. Duval, Y. Muizert, T. H. Hijzen, H. E. Junginger, A. Frankhuyzen-Sierevogel, A. Nelemans, Rob Leurs, V. M. Wiegant, M. Pfaffendorf, A. M. B. Bouhuizen, E. J. J. v. Tintelen, E. H. Cox, J. F. de Vlieger, Hendrik Timmerman, Gert Folkerts, M. R. Dzoljic, Meindert Danhof, G. S. Madretsma, T. Muis, R. E. J. ten Berge, J. Stolte, A. H. Mulder, A. Yamatodani, G. Ph. Biewenga, C. G. Olymulder, H. E. Molewijk, E. de Jong, K. van der Molen, W. Vleeming, L. Groenink, H. A. A. Van Heugten, P. M. H. Schiffers, Carolina R.S. Elzinga, B. C. H. Teisman, T. Hijzen, T. A. Bruning, R. J. Vermeulen, O. H. M. Beenen, Frans P. Nijkamp, A. G. N. van Hemert, Heleen Scheerens, F. N. G. Doornekamp, H. A. J. Struyker Boudier, R. Gerth van Wijk, M. A. D. H. Schalekamp, Raymund A.C. Roos, Jaap Wilting, B. H. R. Wolffenbuttel, J. Smit, A. den Hertog, J. Oosting, N. L. U. van Meeteren, F. J. Blomjous, Edwin E. Zvartau, H. B. van Wezel, Jan M. van Ree, F. Hogenboom, J.H.J. Copius Peereboom-Stegeman, J. J. de Bie, Gudarz Sadeghi Hashjin, F. J. Zijlstra, A. C. Wouterse, P. D. Verdouw, M. Schuiling, C. J. J. Avezaat, F. R. L. Crijns, J. A. Bouwknecht, Mahnaz Shirmohammadi, D. van Heuven-Nolsen, L. M. Broersen, J. H. Brakkee, E. Bos, A. Bast, F. Nijkamp, P. G. M. Bloemen, A. J. Nicastia, Pramod R. Saxena, G. Hofman, C. Borst, S. L. T. Cappendijk, J. L. Slangen, P. M. Verdouw, E. A. Dubois, J. M. Van Oosterhout, A. N. M. Schoffelmeer, J. P. Van Kats, C. M. Kasbergen, R. Masereeuw, P. A. Van Zwieten, Robert P. Coppes, H. A. J. Struijker Boudier, A. Maas, P. Voorn, Douwe D. Breimer, M. J. A. P. Daemen, Willem A. Bax, Ferdi Engels, K. L. Kam, F. P. Jansen, T. L. Buckley, W. B. Stam, A. G. De Boer, R. de Vries, Willem Hendrik Gispen, R. J. E. Joordens, G. H. K. Tjon, H. Van Loveren, E. Velema, D. L. Brouwers, G. R. M. M. Haenen, A. M. van der Poel, D.J. de Wildt, A. Pijpers, P. R. Saxena, L. M. A. Sassen, J. Gommans, J. Peter, T. Mochizuki, J. Zhang, J. L. de Boer, Mirjam A.F.M. Gerrits, H. van de Meent, Frans P. Niikamp, L. M. de Lannoy, Alexander H. J. Danser, C. van den Berg, F. P. Nijkamp, W. H. Gispen, Jos F.M. Smits, J. P. M. Dam, T. van Laar, H. Burbach, E. A. J. Kalkman, Johan Zaagsma, A. H. J. Herremans, J. Mos, Af Roffel, W. M. Moons, Theresa L. Buckley, H. E. Boddé, P. Nestby, G. Wardeh, E. A. Winkler Prins, P.F. van Bergen, J. Wemer, P. C. J. J. Passier, C. M. A. M. van der Horst, C. M. Mohede, M. J. Post, E. A. Van Royen, J. C. Compaan, P.W.J. van den Wijngaard, P. C. Chang, J. Zwavelina, A. R. Cools, R. E. Santing, M. A. Gingras, F. P. Niikamp, M. J. B. Kemme, H. van Essen, M. J. A. Verluyten, M. J. Van De Velde, R. A. Maes, B. Olivier, M. Y. Bilgin, Paul A.J. Henricks, I. M. Garrelds, A. P. M. van Dijk, D. Visser, M. Koopal, H. Drexler, J. H. M. Verheijden, J. Zwaveling, H. Sipma, B. H. Hoiting, C. A. M. Van Kesteren, J. van der Gugten, R. P. W. Heinsbroek, B. C. G. Gho, C. de Graaf-in't Veld, P. A. J. Henricks, E. J. F. Timmenga, Nadezda Patkina, J. Verhoef, A. H. G. J. Schrijvers, D. H. G. Versteeg, L.A.M.G. van Leengoed, N. Michiels, E.M. van der Aa, and Roger A.H. Adan

Subjects
Pharmacology, Medical education, business.industry, Pharmaceutical Science, Medicine, Pharmacology (medical), Pharmacy, General Medicine, Toxicology, business
Published
1994

5. Disappearing adrenal masses

Author

M. P. J. Polak, H. R. Haak, and I. G. Hermsen

Subjects
Adenoma, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Remission, Spontaneous, Adrenal Gland Neoplasms, Physical examination, Metastasis, Diagnosis, Differential, Cystic lesion, Endocrinology, Adrenal masses, Neoplasms, Rectal carcinoma, medicine, Humans, Aged, Abdominal discomfort, Incidental Findings, medicine.diagnostic_test, business.industry, medicine.disease, Adrenal enlargement, Radiology, Differential diagnosis, business, Tomography, X-Ray Computed
Abstract

Adrenal incidentalomas are a common finding due to the increasing use and improved technology of imaging studies. The majority of these enlargements are non-functional and irreversible. Publications on reversible adrenal enlargement are sparse. Our patient, a 66-year-old man, was admitted to the hospital due to abdominal discomfort. He was treated for rectal carcinoma 3 years before, and was now free of disease. Computed tomography (CT) scan showed no abnormalities other than the incidental finding of bilateral adrenal enlargement. Metastasis was suspected. The CEA-level, however, was within normal range and there was no evidence of hormonal overproduction. After 1 month the patient was reviewed. Physical examination and laboratory testing were normal. Surprisingly, the CT-scan showed a decreased size of both adrenals and after 3 months even showed completely normalized adrenals. Reversible adrenal enlargements are rare. Commonly described causes of adrenal enlargement are haematomas, cystic lesions and infections of the adrenal glands. The patient in this case did not show any clinical, laboratory or radiological signs of any of these diagnoses. The current existing differential diagnosis for bilateral adrenal enlargement is not sufficient to explain the findings in our patient.

Published
2010

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