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1. Concealed cardiomyopathy as a frequent cause of idiopathic ventricular fibrillation in a representative Czech cohort of survivors of sudden cardiac arrest (SCA)

Author

Peter Kubuš, Milan Macek, V Zoubkova, Vlastimil Vančura, Petr Peichl, J Kautzner, M Segetova, Marek Sramko, T Tavacova, Jan Janoušek, J Haskova, Tomáš Roubíček, P Peldova, A Krebsova, and P Votypka

Subjects
medicine.medical_specialty, Scn5a gene, biology, business.industry, Cardiomyopathy, Cardiac arrhythmia, Sudden cardiac arrest, medicine.disease, Sudden cardiac death, Physiology (medical), Internal medicine, Cohort, medicine, Cardiology, biology.protein, KvLQT1, medicine.symptom, Idiopathic ventricular fibrillation, Cardiology and Cardiovascular Medicine, business
Abstract

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Health of the Czech Republic Introduction The complex diagnostic work up in SCA survivors often does not yield a concrete cardiological diagnosis. Moreover, there is conflicting evidence whether genetic testing could support or guide clinical diagnostics. Purpose To assess the molecular architecture of idiopathic ventricular fibrillation in cases without apparent evidence of specific structural or arrhythmic cardiac disease at initial diagnostic work up in a representative Czech cohort. Patients and Methods Between 2013 - 2020 we have ascertained 100 SCA survivors (54 M / 46 F; age range at cardiac arrest 5-69 years). Genetic counselling was followed by massively parallel DNA sequencing using custom-made panels comprising 100 cardiac conditions-related genes. Subsequently, thorough cardiological screening examinations in first degree relatives were carried out. Presence of pathogenic variants was validated by Sanger DNA sequencing and through family segregation analyses. Results Highly likely or certain molecular aetiology (i.e. based on the presence of Class 4 or 5 variants) was disclosed in 20/100 (20%) in PKP2 (3x), SCN5A (4x), RYR2 (3x), TTN (2x), PLN, FLNC, PRKAG2, KCNH2, KCNQ1, SLC4A, TNNT2, and DSP. Interestingly, the KCNE1 p.Asp85Asn (LQT 5 lite) variant, was detected in further 3/100 cases, representing a recognized risk factor for ventricular arrhythmias. Conclusions Genetic testing facilitates stratification of the cause of arrhythmia in a substantial portion of SCA survivors. The utility of positive outcomes of genetic testing was substantiated in 10/20 gene positive patients, where the genetic stratification led to diagnosis of concealed arrhythmogenic cardiomyopathy, whose extent of morphological changes was under the diagnostic sensibility of imaging modalities or ECG. Our results enable individualized care in SCA survivors and assure targeted preventive approaches in their relatives.

Published
2021

2. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1

Author

Amardeep Ghosh Dastidar, Rebecca Kozor, Zorba Blázquez Bermejo, L.M. Desroche, J. Broncano, Heerajnarain Bulluck, Peter P Swoboda, A Barison, Chrysanthos Grigoratos, Sheraz A. Nazir, S. Oebel, R. Kockova, Giulia Careri, Estefania De Garate, Patrizia Pedrotti, Antonella Meloni, Gianluca Pontone, F. Macaione, R. Murdoch, F. Valente, Komal S Safdar, Tobias Rutz, Shimon Kolker, Stephanie Funk, D. Beitzke, P. Garg, Alexandros Kallifatidis, Upasana Tayal, Andrew D Scott, Rick Wage, Pedro Ferreira, Dudley Pennell, Xiaodong Zhong, Fred Epstein, David Firmin, Sanjay Prasad, Anastasios Prousalis, Sophia-Anastasia Mouratoglou, George Giannakoulas, Xenia Deligianni, Michail Bakaloudis, Nikolaos Magganaris, George Sianos, Haralampos Karvounis, Francesco Santini, R. Aziz, J.R.J. Foley, G. Fent, T.A. Musa, P. Haaf, L. Dobson, P.P. Swoboda, J.P. Greenwood, S. Plein, R.J.V.D. Geest, J.J.M. Westenberg, S. Rasul, W. Wadsak, M. Mitterhauser, R. Nolz, M. Stelzmueller, C. Loewe, M. Hacker, Josephine Kermer, Serkan Dogangüzel, Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger, Giora Weisz, Naama Bogot, Irit Hadas Halpern, Arik Wolak, Giulia Ginami, Davide Piccini, Simone Coppo, Gabriella Vincenti, Matthias Stuber, Jürg Schwitter, Xuexin Gao, Stephanie Ambach, Michal D Taylor, Ryan Moore, Robin J Taylor, Olga Toro-Salazar, John L Jeffries, Cheryl Bartone, Subha V Raman, Wojciech Mazur, J.F. Rodriguez-Palomares, L. Gutierrez, V. Pineda, B. Agliano, L. Galian, G. Teixido, M.T. Gonzalez-Alujas, A. Evangelista, D. Garcia-Dorado, S. Gandy, R. Nicholas, G. Houston, P. Martin, J. Muir, S. Matthew, P. Guntur- Ramkumar, I. Cavin, A. Barison, I. Pescetelli, F. Pali, F. Pizzino, A. Terrizzi, D. Di Lisi, G. Novo, G. Todiere, P. Assennato, S. Novo, G.D. Aquaro, Elisa McAlindon, Jonathan Rodrigues, Anna Baritussio, Alessandra Scatteia, Chris Benny Lawton, Tamas Erdei, Gergely Szantho, Mark Hamilton, Chiara Bucciarelli-Ducci, Daniele Andreini, Cristina Rota, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Virginia Beltrama, Anna Solbiati, Andrea I. Guaricci, Mauro Pepi, Konstantinos Bratis, Markus Henningson, Matteo Dell'Omodarme, Valentina O. Puntmann, Eike Nagel, Nicola Giunta, Pietro Giuliano, Maria Giovanna Neri, Gennaro Restaino, Stefania Renne, Alessandra Quota, Vincenzo Positano, Daniele De Marchi, Alessia Pepe, Paola Campadello, Gabriella Masciocco, Rita Facchetti, Angela Milazzo, Giuseppina Quattrocchi, Cristina Giannattasio, Maria Frigerio, Alberto Roghi, Ornella Rimoldi, Antonio Amadu, Giuseppe Venuti, Jonathan C. Rodrigues, Serenella Castelvecchio, Antonia Camporeale, Francesco Secchi, Lorenzo Menicanti, Massimo Lombardi, K. Sedlacek, D. Wichterle, V. Sikula, J. Tintera, L. Sukupova, D. Kautznerova, M. Segetova, A. Praveckova, R. Langova, L. Kryze, W. El-Husseini, J. Kautzner, B. Dinov, A. Arya, S. Hilbert, P. Sommer, A. Bollmann, G. Hindricks, I. Paetsch, C. Jahnke, John P. Greenwood, Abhishek Shetye, Jamal N. Khan, Anvesha Singh, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Anthony Gershlick, Gerry P. McCann, Riccardo Liga, Elena Bennatti, Andrea Barison, Giancarlo Todiere, Giovanni Donato Aquaro, Michele Emdin, Pier Giorgio Masci, A Ortalda, G Todiere, C Grigoratos, G Vergaro, G Mirizzi, N Martini, D De Marchi, P Keilberg, C Passino, GD Aquaro, M Emdin, Adam K McDiarmid, Bara Erhayiem, Graham J Fent, Laura E Dobson, Pankaj Garg, Tarique A Musa, James R Foley, Stephen P Page, John P Greenwood, Sven Plein, Stefania Rosmini, Amna Abdel-Gadir, Anish Bhuva, Thomas A Treibel, Steven K White, Marianna Fontana, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy, A. Luna, T. Martin – Noguerol, P. Caro, R. Toro-Cebada, J. Sanchez – Gonzalez, O. Milleron, B. Safar, Y. Lavie-Badie, D. Millischer, J. Abtan, G. Jondeau, Emilio Cuesta, Sandra O. Rosillo, Gabriela Guzmán, Inmaculada Pinilla, Óscar González, Juan Caro, Inés Ponz, Teresa López, Elena Refoyo, Sabrina Nordin, Silvia Castelleti, Gabriella Captur, Rick Steeds, Shanat Baig, Stuart M Grieve, Gemma A Figtree, Priyanka Singhal, Julian Strange, Angus Nightingale, Andreas Baumbach, Tom Johnson, and Victoria Delgado

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016

3. P4231Diagnostic yield of longer-term non-invasive trans-telephonic ECG monitoring: results of a 6-year study in 12.789 patients

Author

Brada J, A Palanova, E Blaschova, V Dlugosova, J Gandalovicova, M Cernosek, S Sobotkova, H Wunschova, L Ondraskova, Martin Fiala, D Kvasnickova, Veronika Bulková, M Segetova, D Kovarikova, and P Lanikova

Subjects
Ecg monitoring, medicine.medical_specialty, business.industry, Internal medicine, Yield (finance), Non invasive, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Term (time)
Published
2018

4. Poster session: Dobutamine stress echo

Author

C. Vizza, X. Jeanrenaud, M. Satendra, L. Monti, A. Kovacs, D. Vanoli, V. Charles, A. Kardos, M. Chiarlo, C. Gruner, C. Monaco, A. Kuch-Wocial, K. Mizia-Stec, L. Sargento, D. Kautznerova, N. Resseguier, G. Tamborini, C. Cruz, P. Jurzak, A. Cogo, E. Lira, D. Al Mesned, Y. Aizawa, A. Chmiel, R. Corti, K. Kim, G. N. Elkilany, M. Haarman, R. Badagliacca, R. Weber, R. Bruno, L. Di Pino, I. Kaplanis, D. Kalimanovska-Ostric, D. Tsounis, M. Varoudi, H. Yoon, P. Goncalves, G. Mpitsios, I. Garcia-Lunar, P. Min, R. Mogelvang, K. Gieszczyk-Strozik, A. Blundo, A. Tarr, E. W. Remme, David Garcia-Dorado, V. Petronilli, A. Patel, C. Sousa, R. M. Lang, J. Mcghie, V. Monivas Palomero, C. Nomura, H. Yoshikawa, N. Lagopati, M. Gomberg-Maitland, R. Kalil, H. K. Jeon, K. Mrabet, A. Riberi, C. Zito, A. Khalatbari, D. Tarasov, L. Fusini, P. Marques, S. Hassantash, I. Zimbarra Cabrita, M. Francone, A. Germain, A. Theron, J. Sousa, A. Kantorova, F. Collart, C. J. Vrints, A. Forteza, C. Tamburino, D. Cerna, S. Buccheri, M. Taborsky, I. P. Monte, F. Elmkies, A. Castro Beiras, S. Ranjbar, A. Perpinia, O. A. Tolba, R. Pretre, T. Chua, F. Fedele, M. Calcagnino, D. Dragulescu, M. Greutmann, M. Pepi, M. Bartesaghi, S. Urheim, R. Muscariello, F. Ben Moussa, W. Saib, M. Thameur, J. Ternacle, V. Matzraki, M. Ghannouchi, G. Kocabay, A. Margulescu, R. Sicari, R. Ippolito, M. Kloeckner, A. Toth, J. Gonzalez Mirelis, K. Sugi, M. Geleijnse, T. Otsuka, A. Hervold, S. Benyoussef, B. Basnyat, H. Suomi, L. Gargani, M. Stosic, P. Monney, J. Segovia Cubero, M. Karvandi, P. Sousa, J. Gonzalez-Mirelis, P. Caso, M. Murata, M. Vieira, C. Fulcheri, M. Júlia Maciel, P. Garcia-Pavia, M. Bobbo, J. Sun, B. Nardi, V. Pyrgakis, J. W. Kim, F. Alamanni, D. Ozel, A. Cordovil, S. Cimino, S. Papa, A. Carro, E. Leiballi, S. Karakas, J. Cho, C. Mornos, H. Masai, M. D'angelo, S. Mingo Santos, J. Kang, N. Nishiyama, J. Brugada, W. Tsang, Y. Yoon, B. Herzog, F. Dominguez Rodriguez, G. Ertl, E.R. Valsangiacomo Buechel, H. Shin, M. Palinsky, P. Gaudron, O. Gaemperli, A. Bouzas Mosquera, R. Bogle, J. Rodriguez-Palomares, N. Liel-Cohen, J. Burrello, M. Henein, H. Yilmaz, M. Laine, C. Foucher, K. Tanimoto, P. Schiattarella, G. Teixido, V. Schiano Lomoriello, M. R. El-Shanshory, N. Lousada, T. Minarik, F. Machado, G. Hashimoto, Y. Ishikawa, P. Atkinson, I. Zairi, B. Lee, V. Lanska, T. Biering-Sorensen, D. Vinereanu, H. Dores, M. Nakamura, R. Kockova, A. Chenzbraun, A. Manrique, N. A. Garcia, C. Zimmermann, L. Carpinteiro, H. Youn, J. Guimaraes, P. Meimoun, M. Mohammed, A. Gaspar, G. Styczynski, M. Castella, R. Esposito, A. Karavidas, F. Tosello, J. Mills, J. E. Sanderson, Y. Lau, D. Lee, C. Chin, M. Dostanic, D. Liu, P. Lupinek, T. Sato, M. Lewis, M. Reali, E. Cervesato, A. Apor, D. Sharif, S. Leggio, T. Ono, S. Wos, S. Kadrabulatova, S. Miyoshi, B. Milakovic, M. Gonzalez-Alujas, Y. Y. Lam, W. Tietge, M. Tramarin, L. Balzarini, E.-S. El-Hawary, G. E. Nagib Elkilany, P. Lim, P. Lindqvist, F. Veronesi, G. Flahaut, M. Thomas, A. Redheuil, Y. Ahn, M. Galderisi, M. Cavero Gibanel, J. Roquette, G. D. Lenders, F. Cicogna, P. Nihoyannopoulos, S. Taddei, C. Shahla, O. Mirea, A. Aleixo, E. Altekin, A. Milan, J. Roncalli, V. Mor-Avi, P. Crapanzano, S. Wang, A. Rodrigues, D. De Palma, M. Sitges, J. Peteiro, G. Maldonado, A. Nagy, J. Wang, M. Miglioranza, M. J. Claeys, J. Kluin, R. H. Strasser, J. Masura, B. Pezzuto, S. Aakhus, M C De Knegt, F. Broullon, N. Bhave, Y. Kusunose, R. Domburg, S. Moral Torres, J. Song, G. Carlomagno, P. Carrilho-Ferreira, A. Mornos, K. Sedlacek, Y. Villain, S. Arapi, M. Segetova, T. Le Tourneau, M. Kucuk, H. Tsuruta, J.-L. Monin, L. Badano, C. Mueller, C. Jorge, J. Kautzner, U. Schubert, L. Zhong, B. Suran, J. Clerc, I. Demir, S. Chamuleau, P. Tittel, E. Boussabah, P. Punjabi, L. Guimaraes, C. Magnino, B. Delasalle, D. Leone, J. Gruenenfelder, H. Blafield, F. Thuny, J. Jensen, J. Silva Cardoso, S. Stoebe, S. Sioua, K. Fukuda, M. Nocioni, P. Linden, V. Sanchez, D. Silva, V. Sikula, F. Pizzino, L. Kryze, A. Lebreiro, M. Deljanin-Ilic, A. Arsenio, S. Takatsuki, M. Kaldararova, A. Sikora-Puz, M. Cinello, S. Naffati, M. Pirscova, V. Lisignoli, A. Hagendorff, T. Iwaki, M. Niemann, E. Rees, U. Rosenschein, V. Vrsanska, C. A. Szmigielski, G. L. Nicolosi, G. Di Bella, D. Pfeiffer, R. Giorgi, K. Korpi, E. Paucca, M. Sanchez Garcia, S. Kammoun, M. Rodolico, Arturo Evangelista, I. Baka, J. Lima, C. Yu, B. Hong, C. Fischer, P. Morera, F. C. Tanner, R. Manganaro, M. Mezzapesa, B. Seifert, A. Berruezo, H. Guterman, K. Sveric, U. Wiklund, R. Sant'anna, R. Piazza, L. Oreto, L. Mont, J. Rosso, B. P. Paelinck, S. Severino, J. Park, S. Morhy, S. Mingo, A. Ledakowicz-Polak, L. Arcari, E. E.-S. El-Hawary, E. Caiani, R. Fabregas Casal, A. Bensaid, N. A. E.-A. El-Shitany, F. Veglio, L. Gutierrez, R. Massey, R. Mimo, A. Yanikoglu, A. Al Akhfash, J. Rodriguez Garrido, S. Kovalova, N. Patrascu, M. Liu, B. Bijnens, J.-L. Dubois-Rande, M. Suzuki, I. Garcia Lunar, D. Muraru, S. Iwanaga, R. Borras, R. Karpov, T. Nastasovic, T. Gonzalez-Alujas, M. Jasinski, H. Marques, W. Voelker, D. Maan Hasson, K. Murbrach, J. Yoon, M. Cusma-Piccione, S. Carerj, E. Hopp, D. A. Rees, M. Zielinska, M. Forkmann, M. Sotiropoulos, I. Zegri, Y. Neuder, V. Hraska, R. Iengo, I. Losano, P. Gripari, J. Avierinos, I. Simkova, M. Yaacobi, F. Weidemann, C. Sordelli, H. Jeong, T. Osaki, M. Kubanek, R. Sharma, M. Yamamoto, D. Bettex, J. Sivertsen, G. Bruno, A E Van Den Bosch, P. Kracht, P. L. Van Herck, J. Roos-Hesselink, D. Cozma, E. Teiger, L. Said, B. Freed, A. Loimaala, T. Pinho, L. Pomidori, A. Mantovani, A. Santoro, R. Kadour, R. Calabro, S. Rim, L. Sim, B. Merkely, P. Gueret, R. Jansen, G. Curatolo, C.H. Attenhofer Jost, C. Gambardella, V. Jarvinen, P. Hol, D. Mihalcea, P. Sogaard, D. Peluso, O. Kretschmar, F. Fang, H. Cuellar, F. Maffessanti, R Palma Dos Reis, J. Grapsa, A. Sharif-Rasslan, H. Kwon, P. Novak, R. Gallet, C. Sportouch, O. Enescu, H. Chung, M. Valtonen, D. Dawson, A. G. Fraser, M. Lyra Georgosopoulou, Q. Shang, V. Leonelli, L. Agati, A. Khalil, G. Habib, M. Cavero, A. Ionac, M. Florescu, S. Pescariu, L. Ascione, M. Carmo, A. Marouen, A. D'Andrea, S. Champagne, S. Iliceto, J. P. Halcox, M. Mizia, Z. Gasior, M. Cramer, S F de Marchi, S. Goncalves, L. Dal Bianco, N. Cortez-Dias, U. Richter, I. Santos, U. Naslund, E. Gonzalez Lopez, M. Rover, H. Vago, A. E.-A. El-Shitany, G Teixido Tura, M. Sramko, J. Necas, S. Fennira, M. Gomez Bueno, L. Zakhama, L. Costanzo, H. Zemir, F. Dunstan, R. Pecoraro, R. Hocking, L. Gabrielli, R. Tan, J. Tintera, L. Pratali, V. Monivas, B. Bouzas Zubeldia, B. Segafredo, T. Leiria, R. Mincu, A. Kaczynska, L. Petrescu, J. M. Bosmans, A. Ben Yaala, A. Ploussi, K. Hu, Z. Frikha, L. De Luca, E. Choi, J. Yanez Wonenburger, I. Serbanoiu, C. Iacoboni, J. Trochu, S. Montserrat, X. Luo, E. Pavlukova, D. Martinez Ruiz, G. Lazaros, B. Tan, D. Hudziak, J. Petrovicova, S. Herrmann, P. Biaggi, E. Picano, I. E. Rodrigus, Y. Lam, M. Jeong, M. Fedorco, P. Beltran Correas, C. Felix, L. Polak, C. Wunderlich, S. Hohlfeld, S. Tripepi, M. Haberka, R. Poscia, L. Halmai, A. Luycx-Bore, K. Tunstall, D. Becker, H. Dave, P. Lemarchand, and M. Carvalho

Subjects
Leading edge, business.industry, Reference values, Healthy subjects, Medicine, Radiology, Nuclear Medicine and imaging, Geometry, General Medicine, Edge (geometry), Cardiology and Cardiovascular Medicine, business
Published
2012

5. The effect of metformin on energetic metabolism in patients with type 2 diabetes/prediabetes and chronic heart failure

Author

K. Velebova, E. Stolarikova, Hana Malinska, T. Pelikanova, Vojtech Melenovsky, Jiri Veleba, Jan Kopecky, M. Segetova, and L. Belinova

Subjects
medicine.medical_specialty, business.industry, Metabolism, Type 2 diabetes, medicine.disease, Metformin, Heart failure, Internal medicine, Cardiology, Medicine, In patient, Prediabetes, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2018

6. 1030Role of cardiac magnetic resonance and echocardiography prior to cardiac resynchronization therapy

Author

J Tintera, V Sikula, L Kryze, J Kautzner, W El-Husseini, D Kautznerova, K Sedlacek, R Kockova, M Segetova, and D Cerna

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Internal medicine, Cardiology, medicine, Cardiac resynchronization therapy, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, Cardiac magnetic resonance, business
Published
2013

7. Glucose Homeostasis, Pancreatic Endocrine Function, and Outcomes in Advanced Heart Failure.

Author

Melenovsky V, Benes J, Franekova J, Kovar J, Borlaug BA, Segetova M, Tura A, and Pelikanova T

Subjects
Aged, Biomarkers blood, Cachexia blood, Cachexia diagnosis, Cachexia physiopathology, Case-Control Studies, Female, Glucose Tolerance Test, Heart Failure diagnosis, Heart Failure physiopathology, Homeostasis, Humans, Insulin blood, Islets of Langerhans physiopathology, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Risk Factors, Severity of Illness Index, Time Factors, Ventricular Dysfunction, Right blood, Ventricular Dysfunction, Right diagnosis, Ventricular Dysfunction, Right physiopathology, Ventricular Function, Right, Blood Glucose metabolism, Glucagon blood, Heart Failure blood, Islets of Langerhans metabolism
Abstract

Background: The mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis in patients with nondiabetic advanced HF., Methods and Results: In total, 140 advanced HF patients without known diabetes mellitus and 21 sex-, age-, and body mass index-matched controls underwent body composition assessment, oral glucose tolerance testing, and measurement of glucose-regulating hormones to model pancreatic β-cell secretory response. Compared with controls, HF patients had similar fasting glucose and insulin levels but higher levels after oral glucose tolerance testing. Insulin secretion was not impaired, but with increasing HF severity, there was a reduction in glucose, insulin, and insulin/glucagon ratio-a signature of starvation. The insulin/C-peptide ratio was decreased in HF, indicating enhanced insulin clearance, and this was correlated with lower cardiac output, hepatic insufficiency, right ventricular dysfunction, and body wasting. After a median of 449 days, 41% of patients experienced an adverse event (death, urgent transplant, or assist device). Increased glucagon and, paradoxically, low fasting plasma glucose displayed the strongest relations to outcome ( P =0.01). Patients in the lowest quartile of fasting plasma glucose (3.8-5.1 mmol·L -1 , 68-101 mg·dL -1 ) had 3-times higher event risk than in the top quartile (6.0-7.9 mmol·L -1 , 108-142 mg·dL -1 ; relative risk: 3.05 [95% confidence interval, 1.46-6.77]; P =0.002)., Conclusions: Low fasting plasma glucose and increased glucagon are robust metabolic predictors of adverse events in advanced HF. Pancreatic insulin secretion is preserved in advanced HF, but levels decrease with increasing HF severity due to enhanced insulin clearance that is coupled with right heart failure and cardiac cachexia., (© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.)

Published
2017
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