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Recent studies have shown that variations in the parameters of the laser powder bed fusion (LPBF) process significantly impact the microstructure and thermomechanical properties of NiTi shape memory alloys (SMAs). Understanding how parameter selection influences the final NiTi SMA properties enables the strategic design of additively manufactured (AM) components with tailored mechanical and transformation behavior, suitable for specific applications in a plethora of scientific fields. However, the connection between processing and thermomechanical properties of NiTi SMAs is still not completely understood. This study investigates the effects of AM parameters laser power (72–185 W), scanning speed (668-1739 mm/s), and hatch spacing (28–85 μm) on a near equiatomic NiTi powder. Low porosity levels are found in the samples additively manufactured (AM) with the different LPBF parameter combinations. The findings also reveal that transformation temperatures and nickel evaporation trends correlate directly with volumetric energy density (VED). Additionally, the amount of Ti2Ni precipitates increases with higher VED. Thermal cycles under constant stress, training, and two-way shape memory effect tests have been performed; the results demonstrate a strain recovery ratio of 2–3.5% for most of the samples. The results arising from this study pave the way for the engineering of customized materials with tailored properties from the same alloy metal powder.

The Andes are an emblematic active Cordilleran orogen. Mountain building in the Central Andes (∼20∘ S) started by the Late Cretaceous to early Cenozoic along the subduction margin and propagated eastward. In general, the structures sustaining the uplift of the western flank of the Andes are dismissed, and their contribution to mountain building remains poorly constrained. Here, we focus on two sites along the Western Andes at ∼20–22∘ S in the Atacama desert, where structures are well exposed. We combine mapping from high-resolution satellite images with field observations and numerical trishear forward modeling to provide quantitative constraints on the kinematic evolution of the investigated field sites. When upscaling our local field interpretations to the regional scale, we identify two main structures: (1) the Andean Basement Thrust, a west-vergent thrust system placing Andean Paleozoic basement over Mesozoic strata, and (2) a series of west-vergent thrusts pertaining to the West Andean Thrust System, deforming primarily Mesozoic units. From our interpreted sections, we estimate that both structures together accommodate at least ∼6–9 km of shortening across the sole investigated ∼7–17 km wide field sites. This multi-kilometric shortening represents only a fraction of the total shortening accommodated across the whole Western Andes. The timing of the main deformation recorded in the folded Mesozoic series can be bracketed between ∼68 and ∼29 Ma – and possibly between ∼68 and ∼44 Ma – from dated deformed geological layers, with a subsequent significant slowing-down of shortening rates. Even though the structures forming the Western Andes only absorbed a small fraction of the total shortening across the whole orogen, their contribution was relatively significant at the earliest stages of Andean mountain building before deformation proceeded eastward.

The availability of crop type reference datasets for satellite image classification is very limited for complex agricultural systems as observed in developing and emerging countries. Indeed, agricultural land use is very dynamic, agricultural censuses are often poorly georeferenced and crop types are difficult to interpret directly from satellite imagery. In this paper, we present a database made of 24 datasets collected in a standardized manner over nine sites within the framework of the international JECAM (Joint Experiment for Crop Assessment and Monitoring) initiative; the sites were spread over seven countries of the tropical belt, and the number of data collection years depended on the site (from 1 to 7 years between 2013 and 2020). These quality-controlled datasets are distinguished by in situ data collected at the field scale by local experts, with precise geographic coordinates, and following a common protocol. Altogether, the datasets completed 27 074 polygons (20 257 crops and 6817 noncrops, ranging from 748 plots in 2013 (one site visited) to 5515 in 2015 (six sites visited)) documented by detailed keywords. These datasets can be used to produce and validate agricultural land use maps in the tropics. They can also be used to assess the performances and robustness of classification methods of cropland and crop types/practices in a large range of tropical farming systems. The dataset is available at https://doi.org/10.18167/DVN1/P7OLAP (Jolivot et al., 2021).

Additive Manufacturing (AM) has enabled the fabrication of metallic cellular materials that are of interest in the design of lightweight impact resistant structures. However, there is a need to understand the interactions between: (i) the material architecture, (ii) the AM process parameters, and (iii) the as-built geometry, microstructure and energy absorbing properties. In this work, we investigate the quasi-static and dynamic behaviour of cellular materials manufactured from 316L stainless steel using laser powder bed fusion (LPBF). Four cellular architectures are considered (octet lattice, lattice-walled square honeycomb, origami and square honeycomb), as well as three sets of AM process parameters, characterised by laser powers of 50, 125 and 200 W. The exposure time is adjusted to deliver the same total heat input. The 125 W case leads to material with the highest strength and ductility. The cellular materials with this process variant match their nominal densities most closely, and have the highest strength and energy absorption. Either reducing (50 W) or increasing (200 W) the power leads to a significant increase in porosity, reducing strength and energy absorption. However, we find that changes due to process-induced porosity have a smaller influence than those resulting from the choice of cellular architecture.

The quantification of active tectonics from geomorphological and morphometric approaches commonly implies that erosion and tectonics have reached a certain balance. Such equilibrium conditions are however rare in nature, as questioned and documented by recent theoretical studies indicating that drainage basins may be perpetually re-arranging even though tectonic and climatic conditions remain constant. Here, we document these drainage dynamics in the Bhutan Himalaya, where evidence for out-of-equilibrium morphologies have for long been noticed, from major (> 1 km high) river knickpoints and from high-altitude low-relief regions in the mountain hinterland. To further characterize these morphologies and their dynamics, we perform field observations and a detailed quantitative morphometric analysis using χ plots and Gilbert metrics of drainages over various spatial scales, from major Himalayan rivers to their tributaries draining the low-relief regions. We first find that the river network is highly dynamic and unstable, with much evidence of divide migration and river captures. The landscape response to these dynamics is relatively rapid. Our results do not support the idea of a general wave of incision propagating upstream, as expected from most previous interpretations. Also, the specific spatial organization in which all major knickpoints and low-relief regions are located along a longitudinal band in the Bhutan hinterland, whatever their spatial scale and the dimensions of the associated drainage basins, calls for a common local supporting mechanism most probably related to active tectonic uplift. From there, we discuss possible interpretations of the observed landscape in Bhutan. Our results emphasize the need for a precise documentation of landscape dynamics and disequilibrium over various spatial scales as a first step in morpho-tectonic studies of active landscapes.

Basin-averaged denudation rates may locally exhibit a wide dispersion, even in areas where the topographic steady state is supposedly achieved regionally. This dispersion is often attributed to the accuracy of the data or to some degree of natural variability of local erosion rates which can be related to stochastic processes such as landsliding. Another physical explanation of this dispersion is local and transient disequilibrium between tectonic forcing and erosion at the scale of catchments. Recent studies have shown that basin divide migration can potentially induce such perturbations, and they propose metrics to assess divide mobility based on cross-divide contrasts in headwater topographic features. Here, we use a set of landscape evolution models assuming spatially uniform uplift, rock strength and rainfall to assess the effect of divide mobility on basin-wide denudation rates. We propose using basin-averaged aggressivity metrics based on cross-divide contrasts (1) in channel χ, an integral function of position in the channel network; (2) in channel local gradient; and (3) in channel height, measured at a reference drainage area. From our simulations, we show that the metric based on differences in χ is the most reliable to diagnose local disequilibrium. The other metrics are more suitable for relatively active tectonic regions such as mountain belts, where contrasts in local gradient and elevation are more important. We find that the ratio of basin denudation associated with drainage migration to uplift can reach a factor of 2, regardless of the imposed uplift rate, erodibility, diffusivity coefficient or critical hillslope gradient. A comparison with field observations in the Great Smoky Mountains (southern Appalachians, USA) underlines the difficulty of using the metric based on χ, which depends on the – poorly constrained – elevation of the outlet of the investigated catchment. Regardless of the considered metrics, we show that observed dispersion is controlled by catchment size: a smaller basin may be more sensitive to divide migration and hence to disequilibrium. Our results thus highlight the relevance of divide stability analysis from digital elevation models as a fundamental preliminary step for basin-wide denudation rate studies based on cosmogenic radionuclide concentrations.

Introducción: El propósito de la investigación es conocer la eficacia del Secnidazol en el tratamiento de escolares asintornáticos portadores de Giardia lamblia y lo Entamoeba histolytica, así como el evaluar su tolerancia. Material y métodos: Se escogieron 50 niños parasitados (totalizando 53 casos con Entamoeba histolytica y/o Giardia lamblia), con edades comprendidas entre 5 y 14 años, de uno u otro sexo, a quienes se les administró el medicamento y tres días después se realizaron exámenes coproparasitológicos controles. La tolerancia del medicamento se evaluó mediante encuesta. Resultados: De 53 casos parasitados, la relación de protozoarios fue: Giardia lamblia (66,03%) seguidos de Entamoeba histolytica (33,97%). La efectividad parasitológica del Secnidazol contra Giardia lamblia fue del 100% y de Entamoeba histolytica de 95,45%. Se obtuvo un solo caso portador que no respondió al tratamiento (4.55%). El medicamento fue bien tolerado en el 50% de los casos. Los síntomas más frecuentes fueron: hiporexía, cefalea, dolor abdominal, mareos, náuseas, vómitos, diarrea, fatiga, alteración del gusto y prurito. Conclusiones: La eficacia y la relativamente buena tolerancia del Secnidazol fue demostrada en el presente estudio. Se obtuvo cura parasitológica al tercer día de administrado el medicamento.

Introducción: El propósito de la investigación es conocer la prevalencia de las enteroparasitosis en una escuela urbana de la parroquia San Francisco. Material y métodos: Del total de la población escolar, se escogieron 114 niños, de edades comprendidas entre 5 y 15 años, de ambos sexos, donde se les realizó exámenes coproparasitológicos y recolección de información a través de encuestas epidemiológicas. Resultados: De los niños seleccionados. 74,56% reportaron positividad para uno o más enteroparásitos. 40,35% fueron masculinos y 34,21 % femeninos. Las edades más parasitadas fueron las comprendidas entre 9 y 12 años (34,24%) seguidas de 5 a 8 años 30,69%. Los helmintos más frecuentes fueron: Enterobius vermicularis (45,55%), Trichuris trichiura (27,80%), Ascaris lumbricoides (23,35%) e Hymenolepis nana (3,30%) y los protozoos fueron: Blastocystis hominis (37,28%), Giardia lamblia (17,79%), Endolimax nana (16,95%), Entamoeba coli (15.26%). El poliparasitismo predominó sobre el monoparasitismo. Las helmintiasis observadas presentaron en su mayoría una infestación leve. Se evidencia acentuados malos hábitos higiénicos en los niños así como en la escuela.

Nonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise liver function. Mitochondria are key players in obesity-induced metabolic disorders; however, the distinct role of hypercaloric diet constituents in hepatic cellular oxidative stress and metabolism is unknown. Male mice were fed either a high-fat (HF) diet, a high-sucrose (HS) diet or a combined HF plus HS (HFHS) diet for 16 weeks. This study shows that hypercaloric diets caused steatosis; however, the HFHS diet induced severe fibrotic phenotype. At the mitochondrial level, lipidomic analysis showed an increased cardiolipin content for all tested diets. Despite this, no alterations were found in the coupling efficiency of oxidative phosphorylation and neither in mitochondrial fatty acid oxidation (FAO). Consistent with unchanged mitochondrial function, no alterations in mitochondrial-induced reactive oxygen species (ROS) and antioxidant capacity were found. In contrast, the HF and HS diets caused lipid peroxidation and provoked altered antioxidant enzyme levels/activities in liver tissue. Our work provides evidence that hepatic oxidative damage may be caused by augmented levels of peroxisomes and consequently higher peroxisomal FAO-induced ROS in the early NAFLD stage. Hepatic damage is also associated with autophagic flux impairment, which was demonstrated to be diet-type dependent. The HS diet induced a reduction in autophagosomal formation, while the HF diet reduced levels of cathepsins. The accumulation of damaged organelles could instigate hepatocyte injuries and NAFLD progression.

Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.