261 results on '"M. Sundberg"'
Search Results
2. Time-resolved molecular dynamics of single and double hydrogen migration in ethanol
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Nora G. Kling, S. Díaz-Tendero, R. Obaid, M. R. Disla, H. Xiong, M. Sundberg, S. D. Khosravi, M. Davino, P. Drach, A. M. Carroll, T. Osipov, F. Martín, and N. Berrah
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Science - Abstract
Chemical dynamics in molecules involve particle migration and bond rearrangement. Here the authors show single and double hydrogen migration in ethanol cations and dications that are generated by using intense laser pulse interaction with a jet of ethanol molecules.
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- 2019
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3. Markers of Pluripotency and Differentiation in Human Neural Precursor Cells Derived from Embryonic Stem Cells and CNS Tissue
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M. Sundberg, P.-H. Andersson, E. Åkesson, J. Odeberg, L. Holmberg, J. Inzunza, S. Falci, J. Öhman, R. Suuronen, H. Skottman, K. Lehtimäki, O. Hovatta, S. Narkilahti, and E. Sundström
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Medicine - Abstract
Cell transplantation therapies for central nervous system (CNS) deficits such as spinal cord injury (SCI) have been shown to be effective in several animal models. One cell type that has been transplanted is neural precursor cells (NPCs), for which there are several possible sources. We have studied NPCs derived from human embryonic stem cells (hESCs) and human fetal CNS tissue (hfNPCs), cultured as neurospheres, and the expression of pluripotency and neural genes during neural induction and in vitro differentiation. mRNA for the pluripotency markers Nanog , Oct-4 , Gdf3 , and DNMT3b were downregulated during neural differentiation of hESCs. mRNA for these markers was found in nonpluripotent hfNPC at higher levels compared to hESC-NPCs. However, Oct-4 protein was found in hESC-NPCs after 8 weeks of culture, but not in hfNPCs. Similarly, SSEA-4 and CD326 were only found in hESC-NPCs. NPCs from both sources differentiated as expected to cells with typical features of neurons and astrocytes. The expressions of neuronal markers in hESC-NPCs were affected by the composition of cell culture medium, while this did not affect hfNPCs. Transplantation of hESC-NPC or hfNPC neurospheres into immunodeficient mouse testis or subcutaneous tissue did not result in tumor formation. In contrast, typical teratomas appeared in all animals after transplantation of hESC-NPCs to injured or noninjured spinal cords of immunodeficient rats. Our data show that transplantation to the subcutaneous tissue or the testes of immunodeficient mice is not a reliable method for evaluation of the tumor risk of remaining pluripotent cells in grafts.
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- 2011
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4. The Women in Behavior Analysis Hall of Fame: Description and 2021 Inductees
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Linda A. LeBlanc, Chata A. Dickson, Carol Pilgrim, Denise Ross-Page, Devon M. Sundberg, and Carrie Van Hoover
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General Medicine - Published
- 2023
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5. Why WIBA?
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Devon M. Sundberg, Kimberly A. Zoder-Martell, and Sarah Cox
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General Medicine ,Special Section: Diversity and Inclusion - Abstract
Historically, men have dominated the field of behavior analysis; however, recent trends have indicated increased participation by women. As a result of these recent changes to the field of behavior analysis, the inaugural Women in Behavior Analysis Conference (WIBA) was hosted in 2017. WIBA was initially established to highlight the accomplishments of women in the field of behavior analysis, to provide opportunities for early career behavior analysts to obtain mentorship, and to encourage meaningful discourse about gender issues in the field. Since the inaugural conference, WIBA has attempted to establish a platform for promoting gender equality but most recently has incorporated efforts related to the needs surrounding social justice and inclusiveness in the field of behavior analysis. The goal of this paper is to provide an overview of the WIBA conference. The history of WIBA is discussed, including the impetus for establishing the conference. This paper highlights existing issues on gender equality in the field of behavior analysis and the larger community, serves to demonstrate how WIBA is part of the solution, and shares accomplishments to date. Furthermore, future directions and goals are presented.
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- 2019
6. Minimum Stress Trends in Stacked Mass Transport Deposits, Deepwater Guyana
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T. Fitts, S. Karner, M. Sundberg, and S. Hoffmann
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Stress (mechanics) ,Overburden ,Hydrogeology ,Effective stress ,Range (statistics) ,Soil science ,Overburden pressure ,Terzaghi's principle ,Soil mechanics ,Geology - Abstract
Summary In pressure predictions for early Stabroek exploration wells, minimum stress was calculated using the Terzaghi soil mechanics method (Matthews and Kelly, 1967) and a standard range of effective stress ratios according to Shmin=K0(Sv-Pp)+Pp, where Shmin is minimum stress, Sv is the overburden, PP is the pore fluid pressure and K0 is the effective stress ratio. These calculated profiles were compared to minimum stress estimates obtained from leak-off tests, pressure integrity tests, and lost return events. In several cases, the well data suggested significantly higher minimum stresses than predicted, with most tests in the deeper MTDs approaching the estimated overburden stress. To address the applicability of these estimates for minimum stress to future well planning, several interpreted mechanisms for these elevated stresses were proposed and investigated.
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- 2019
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7. A Group-based Patient Education Programme for High-Anxiety Patients with Crohn Disease or Ulcerative Colitis
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Larsson, K, Hjelm, M Sundberg, Karlbom, U, Nordin, K, Anderberg, U M., and Lööf, L
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- 2003
8. Effect of Vascular Endothelial Growth Factor Treatment in Experimental Traumatic Spinal Cord Injury: In Vivo Longitudinal Assessment
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Laura M. Sundberg, Ponnada A. Narayana, and Juan J. Herrera
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Male ,Vascular Endothelial Growth Factor A ,Pathology ,medicine.medical_specialty ,Motor Activity ,Nerve Fibers, Myelinated ,Neuroprotection ,Rats, Sprague-Dawley ,Lesion ,chemistry.chemical_compound ,medicine ,Animals ,Remyelination ,Spinal cord injury ,Spinal Cord Injuries ,medicine.diagnostic_test ,business.industry ,Cell Differentiation ,Magnetic resonance imaging ,Recovery of Function ,Original Articles ,Spinal cord ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Axons ,Rats ,Surgery ,Vascular endothelial growth factor ,Oligodendroglia ,Vascular endothelial growth factor A ,medicine.anatomical_structure ,Spinal Cord ,chemistry ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Vascular endothelial growth factor (VEGF) is thought to provide neuroprotection to the traumatically injured spinal cord. We examined whether supplementing the injured environment with VEGF(165) via direct intraspinal injection into the lesion epicenter during the acute phase of spinal cord injury (SCI) results in improved outcome. The effect of treatment was investigated using longitudinal multi-modal magnetic resonance imaging (MRI), neurobehavioral assays, and end-point immunohistochemistry. We observed on MRI that rats treated with VEGF(165) after SCI had increased tissue sparing compared to vehicle-treated animals at the earlier time points. However, these favorable effects were not maintained into the chronic phase. Histology revealed that VEGF(165) treatment resulted in increased oligodendrogenesis and/or white matter sparing, and therefore may eventually lead to improved functional outcome. The increase in spared tissue as demonstrated by MRI, coupled with the possible remyelination and increased neurosensory sensitivity, suggests that VEGF(165) treatment may play a role in promoting plasticity in the sensory pathways following SCI. However, VEGF-treated animals also demonstrated an increased incidence of persistent allodynia, as indicated on the von Frey filament test.
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- 2011
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9. Vascular Endothelial Growth Factor and Spinal Cord Injury Pain
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Venkata U.L. Mokkapati, Julieann C. Lee, Ponnada A. Narayana, Laura M. Sundberg, Olivera Nesic, and Juan J. Herrera
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Male ,Pain Threshold ,Vascular Endothelial Growth Factor A ,Pathology ,medicine.medical_specialty ,Endogeny ,Motor Activity ,Statistics, Nonparametric ,Rats, Sprague-Dawley ,Random Allocation ,chemistry.chemical_compound ,Downregulation and upregulation ,Physical Stimulation ,medicine ,Animals ,Spinal cord injury ,Spinal Cord Injuries ,Oligonucleotide Array Sequence Analysis ,business.industry ,Original Articles ,medicine.disease ,Spinal cord ,Antibodies, Neutralizing ,Immunohistochemistry ,Rats ,Vascular endothelial growth factor ,Allodynia ,medicine.anatomical_structure ,chemistry ,Hyperalgesia ,Anesthesia ,Neuropathic pain ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Vascular endothelial growth factor (VEGF)-A mRNA was previously identified as one of the significantly upregulated transcripts in spinal cord injured tissue from adult rats that developed allodynia. To characterize the role of VEGF-A in the development of pain in spinal cord injury (SCI), we analyzed mechanical allodynia in SCI rats that were treated with either vehicle, VEGF-A isoform 165 (VEGF(165)), or neutralizing VEGF(165)-specific antibody. We have observed that exogenous administration of VEGF(165) increased both the number of SCI rats that develop persistent mechanical allodynia, and the level of hypersensitivity to mechanical stimuli. Our analysis identified excessive and aberrant growth of myelinated axons in dorsal horns and dorsal columns of chronically injured spinal cords as possible mechanisms for both SCI pain and VEGF(165)-induced amplification of SCI pain, suggesting that elevated endogenous VEGF(165) may have a role in the development of allodynia after SCI. However, the neutralizing VEGF(165) antibody showed no effect on allodynia or axonal sprouting after SCI. It is possible that another endogenous VEGF isoform activates the same signaling pathway as the exogenously-administered 165 isoform and contributes to SCI pain. Our transcriptional analysis revealed that endogenous VEGF(188) is likely to be the isoform involved in the development of allodynia after SCI. To the best of our knowledge, this is the first study to suggest a possible link between VEGF, nonspecific sprouting of myelinated axons, and mechanical allodynia following SCI.
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- 2010
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10. Adherence to Lifestyle Recommendations of Overweight Children in a Structured Weight Management Program
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Margaret A. Braae, Nedra K. Christensen, D. Pauline Williams, Joilynne D. Musselman, Amelia B. McBride, Catherine M. McDonald, and Shannon M. Sundberg
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medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Health behaviour ,Physical activity ,Overweight ,medicine.disease ,Body weight ,Obesity ,Pediatrics, Perinatology and Child Health ,Weight management ,medicine ,Physical therapy ,medicine.symptom ,business ,Body mass index - Published
- 2010
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11. Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander
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Thomas Lundgren, Lars Mattsson, Jonas Lidholm, M. Sundberg, and P. Olsson
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Allergy ,biology ,fungi ,Immunology ,food and beverages ,Lipocalin ,medicine.disease ,Immunoglobulin E ,medicine.disease_cause ,Molecular biology ,law.invention ,Allergen ,Biochemistry ,law ,Complementary DNA ,biology.protein ,medicine ,Recombinant DNA ,Immunology and Allergy ,Antibody ,Escherichia coli - Abstract
Summary Background Dog dander is an important cause of respiratory allergy but its content of allergenic components is still incompletely known. While Can f 1, 2, 3 and 5 have been studied in detail, only fragmentary information is available on the lipocalin Can f 4. Objective To purify, clone and characterize dog dander allergen Can f 4. Methods Can f 4 was purified from dog dander extract by size exclusion, ion exchange and reverse phase chromatography. A cDNA encoding Can f 4 was cloned and used to produce recombinant Can f 4 in Escherichia coli. A 23 kDa protein from cow dander, displaying cross-reactivity with Can f 4, was purified and identified by amino acid sequencing and mass spectrometry. IgE antibody binding to dog and cow dander extract and to individual dog allergens among 37 dog allergic subjects and 44 pollen allergic controls was studied using ImmunoCAP. Results A dog genome segment containing the Can f 4 gene was bioinformatically identified and enabled the cloning of Can f 4 cDNA. Recombinant Can f 4 displayed close immunological and biochemical similarity to purified natural Can f 4 and bound IgE antibodies from 13/37 (35%) sera of dog allergic subjects. Can f 4 reactive sera showed IgE binding to a 23 kDa protein present in cow dander extract, related to a family of odorant-binding proteins. The dog and cow proteins shared 37% sequence identity and their cross-reactivity was demonstrated by IgE inhibition experiments. Conclusion Recombinant Can f 4 brings the panel of available dog allergens closer to completion and will be important in component-resolved diagnostics in allergy to animal epithelial allergens. Cite this as: L. Mattsson, T. Lundgren, P. Olsson, M. Sundberg and J. Lidholm, Clinical & Experimental Allergy, 2010 (40) 1276–1287.
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- 2010
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12. THE EFFECT OF ACTH UPON THE TISSUE EOSINOPHILS AND MAST CELLS IN THE HUMAN GASTRIC MUCOSA
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M. Sundberg, Toimi Räsänen, and M. Siurala
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0303 health sciences ,Pathology ,medicine.medical_specialty ,business.industry ,Stomach ,Histiocytes ,General Medicine ,Eosinophils ,Leukocyte Count ,03 medical and health sciences ,Foveolar cell ,0302 clinical medicine ,medicine.anatomical_structure ,Adrenocorticotropic Hormone ,Gastric Mucosa ,Gastric mucosa ,medicine ,030211 gastroenterology & hepatology ,Mast Cells ,Enterochromaffin-like cell ,business ,030304 developmental biology - Published
- 2009
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13. Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI
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Shi Jie Liu, Pallavi Ahobila-Vajjula, David M. Cohen, Ponnada A. Narayana, Chirag B. Patel, Tessy Chacko, and Laura M. Sundberg
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Pathology ,medicine.medical_specialty ,Cord ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Blood–brain barrier ,medicine.disease ,Spinal cord ,medicine.anatomical_structure ,Traumatic injury ,Permeability (electromagnetism) ,Dynamic contrast-enhanced MRI ,medicine ,Molecular Medicine ,Radiology, Nuclear Medicine and imaging ,skin and connective tissue diseases ,business ,Spinal cord injury ,Spectroscopy - Abstract
After a primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood-spinal cord barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced MRI (DCE-MRI) studies were performed up to 56 days after SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI (non-enhancing tissue). DCE-MRI data were analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. However, on the basis of DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days after SCI. In addition, open-field locomotion was evaluated using the 21-point Basso-Beattie-Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed.
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- 2008
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14. Small bowel obstruction due to antegrade and retrograde intussusception after gastric bypass: three case reports in two patients, literature review, and recommendations for diagnosis and treatment
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David S. Kermode, Matthew Severidt, David D. Coster, Stefanie H. Noun, Stephen M. Sundberg, and Donald T. Beitzel
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Adult ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gastric bypass ,Gastric Bypass ,Ischemia ,Bowel resection ,medicine.disease ,Obesity, Morbid ,Surgery ,Bowel obstruction ,Recurrence ,Intussusception (medical disorder) ,Intestine, Small ,medicine ,Humans ,Female ,Abdominal computed tomography ,business ,Complication ,Intussusception ,Retrograde intussusception - Abstract
Intestinal obstruction due to intussusception, although rare, is a complication that can cause small bowel obstruction after Roux-en-Y gastric bypass. Possible causes include disordered intestinal motility, the presence of staple lines and other lead points in the intestinal wall, and the anatomic peculiarities of the enteroenterostomy. In the case of antegrade intussusception, the lead point is usually identifiable and can involve either limb. Retrograde intussusception is more common but usually has a featureless entry point beginning a few inches below the intestinal anastomosis, with the intussusceptum traversing the enteroenterostomy into either the biliary or Roux limb. Abdominal computed tomography scan is necessary for diagnosis, and early exploration is recommended to avoid ischemia and bowel resection.
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- 2008
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15. Alumina forming high temperature silicides and carbides
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A. Magnusson, M. Sundberg, G. Malmqvist, and T. El-Raghy
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Thermogravimetric analysis ,Materials science ,Process Chemistry and Technology ,Machinability ,Metallurgy ,Oxide ,chemistry.chemical_element ,Partial pressure ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Carbide ,chemistry.chemical_compound ,chemistry ,Molybdenum ,Aluminium ,Materials Chemistry ,Ceramics and Composites ,Vacuum level - Abstract
Aluminium containing heat-resistant silicides and ternary carbides (Maxthal ® ), have been evaluated in terms of their high temperature behaviour in various atmospheres including vacuum. The novelty of these materials is in their ability to form a stable and adherent protective alumina scale at low partial pressures of oxygen as well as in air. Recently developed heating elements, for oxidising and reducing atmospheres, made of molybdenum aluminosilicide (Kanthal Super ER) have been evaluated by thermogravimetric analysis (TGA) studies in air and other atmospheres. The performance up to 1575 °C has been evaluated at vacuum levels down to 10 −4 mbar. In addition to its remarkable thermal shock resistance, damage tolerance and machinability, Ti 2 AlC (Maxthal ® ) showed a parabolic and stable oxide growth rate up to 1400 °C in air. Cyclic testing confirmed that the oxide layer is adherent to the bulk. It has been concluded that both Maxthal ® and Kanthal Super ER are capable of operating in air, up to 1400 and 1575 °C, respectively.
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- 2004
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16. Microstructure, hardness and indentation toughness of high-temperature C40 Mo(Si,Al)2/SiC composites prepared by SPS of MA powders
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Changhai Li, M. Sundberg, Erik G. Ström, and Pavel Krakhmalev
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Toughness ,Materials science ,Scanning electron microscope ,Mechanical Engineering ,Metallurgy ,Intermetallic ,Spark plasma sintering ,chemistry.chemical_element ,Condensed Matter Physics ,Microstructure ,Fracture toughness ,chemistry ,Mechanics of Materials ,Aluminium ,Indentation ,General Materials Science ,Composite material - Abstract
The C40 Mo(Si0.75Al0.25)2 and Mo(Si0.75Al0.25)2/SiC materials containing micro-, nano-scale structure and Mo/Mo5Si3 phases have been prepared by spark plasma sintering (SPS) of mechanically alloyed (MA) powders. Sintered composites have hardness around 14 GPa. The 1.84 MPa m1/2 toughness of C40 Mo(Si,Al)2 can be 30% improved by addition of 20 vol.% SiC.
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- 2003
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17. A Group-based Patient Education Programme for High-Anxiety Patients with Crohn Disease or Ulcerative Colitis
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Kjerstin Larsson, U Karlbom, U M Anderberg, M Sundberg Hjelm, Lars Lööf, and Karin Nordin
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,SF-36 ,Health Status ,Hospital Anxiety and Depression Scale ,Severity of Illness Index ,Inflammatory bowel disease ,Crohn Disease ,Patient Education as Topic ,Quality of life ,Surveys and Questionnaires ,Severity of illness ,medicine ,Humans ,Aged ,business.industry ,Gastroenterology ,Middle Aged ,medicine.disease ,Anxiety Disorders ,Ulcerative colitis ,digestive system diseases ,Treatment Outcome ,Psychotherapy, Group ,Quality of Life ,Physical therapy ,Anxiety ,Colitis, Ulcerative ,Female ,medicine.symptom ,business ,Follow-Up Studies ,Program Evaluation ,Patient education - Abstract
The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn disease (CD) affect a person's health-related quality of life (HRQOL). IBD patients report high levels of anxiety, which correlates with the degree of perceived dissatisfaction with the information on disease-related themes provided in routine health care. The aim of this study was to evaluate changes in anxiety after participation in a group-based educational intervention for IBD patients screened for high anxiety.The programme consisted of 8 sessions, and 49 patients participated. Anxiety was assessed using the Hospital Anxiety and Depression (HAD) Scale at baseline and 6 months after intervention. HRQOL was assessed with the Inflammatory Bowel Disease Questionnaire (IBDQ) and the SF-36 health survey. Participant satisfaction with education was measured using a study-specific questionnaire.No significant change on the HAD anxiety score was found at the 6-month follow-up for those who participated in the education programme despite the fact that the participants reported they had gained better knowledge of disease-related items. Furthermore, there were no significant changes over time regarding bowel symptoms, systemic symptoms, emotional functioning and social functioning of the IBDQ or generic HRQOL (SF-36).IBD patients with a high anxiety level reported improved satisfaction with information about disease-related items, but did not indicate any benefits in terms of reduced anxiety or improved HRQOL after participating in the education programme, not at least in the short-term perspective. In this selected group of patients, psychosocial problems other than disease-related concerns were found that warrant other approaches.
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- 2003
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18. Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury
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Lorena Zentilin, Mauro Giacca, Laura M. Sundberg, Ponnada A. Narayana, Juan J. Herrera, J. J., Herrera, L. M., Sundberg, L., Zentilin, Giacca, Mauro, and P. A., Narayana
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Male ,Vascular Endothelial Growth Factor A ,Pathology ,Angiogenesis ,biosynthesis/genetics, Animals, Behavior ,biosynthesis/genetics ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,genetics ,pathology/therapy, Spinal Cord ,Spinal cord injury ,Behavior, Animal ,medicine.diagnostic_test ,Blotting ,Gene Therapy ,Dependovirus ,Immunohistochemistry ,Magnetic Resonance Imaging ,physiology, Transfection, Vascular Endothelial Growth Factor A ,Hindlimb ,Vascular endothelial growth factor ,Blot ,Vascular endothelial growth factor A ,medicine.anatomical_structure ,Spinal Cord ,physiology, Permeability, Rats, Rat ,medicine.symptom ,Western ,Locomotion ,genetics, Gene Therapy, Genetic Vectors, Hindlimb ,medicine.medical_specialty ,Microinjections ,Blotting, Western ,Genetic Vectors ,Motor Activity ,Biology ,physiology, Blotting ,Sprague-Dawley, Spinal Cord Injurie ,Transfection ,Permeability ,Lesion ,pathology/therapy ,medicine ,Angiopoietin-1 ,Animal ,Western, Dependovirus ,physiology, Immunohistochemistry, Locomotion ,physiology, Magnetic Resonance Imaging, Male, Microinjections, Motor Activity ,physiology, Permeability, Rats, Rats ,Sprague-Dawley, Spinal Cord Injuries ,Animals ,Spinal Cord Injuries ,Behavior ,Magnetic resonance imaging ,Genetic Therapy ,Original Articles ,Spinal cord ,medicine.disease ,Rats ,chemistry ,physiology ,Sprague-Dawley ,Neurology (clinical) ,Western, Dependoviru - Abstract
Spinal cord injury (SCI) results in immediate disruption of the spinal vascular network, triggering an ischemic environment and initiating secondary degeneration. Promoting angiogenesis and vascular stability through the induction of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1), respectively, provides a possible therapeutic approach in treating SCI. We examined whether supplementing the injured environment with these two factors, which are significantly reduced following injury, has an effect on lesion size and functional outcome. Sustained delivery of both VEGF(165) and Ang-1 was realized using viral vectors based on the adeno-associated virus (AAV), which were injected directly into the lesion epicenter immediately after injury. Our results indicate that the combined treatment with VEGF and Ang-1 resulted in both reduced hyperintense lesion volume and vascular stabilization, as determined by magnetic resonance imaging (MRI). Western blot analysis indicated that the viral vector expression was maintained into the chronic phase of injury, and that the use of the AAV vectors did not exacerbate infiltration of microglia into the lesion epicenter. The combined treatment with AAV-VEGF and AAV-Ang-1 improved locomotor recovery in the chronic phase of injury. These results indicate that combining angiogenesis with vascular stabilization may have potential therapeutic applications following SCI.
- Published
- 2010
19. Low temperature oxidation behavior of a MoSi2-based material
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M. Sundberg, Xiaoyun Tu, R. Pompe, Jiaxin Chen, Zhi Fu, and Changhai Li
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Materials science ,Argon ,Scanning electron microscope ,Mechanical Engineering ,Inorganic chemistry ,Analytical chemistry ,chemistry.chemical_element ,Partial pressure ,Atmospheric temperature range ,Condensed Matter Physics ,Microstructure ,Oxygen ,X-ray photoelectron spectroscopy ,chemistry ,Mechanics of Materials ,Phase (matter) ,General Materials Science - Abstract
This article contributes to the characterization of low temperature oxidation behavior of a MoSi 2 composite for heating elements. The initial silica growth kinetics, its oxygen partial pressure dependence, MoO 3 evaporation rate and the microstructural evolution during oxidation have been examined. The oxidation exposure was carried out in the temperature range from 673 to 873 K in flowing oxygen or mixtures of argon and oxygen gases. The major analytical techniques include X-ray powder diffractometry, spectroscopic ellipsometry, X-ray photoelectron spectroscopy, scanning electron microscopy and BET method. It is shown that silica growth rate at 773 K decreases with time and the square of silica thickness increases with the oxygen partial pressure. Evaporation rate of MoO 3 powder increases exponentially with increasing temperature in the range from 823 to 973 K in flowing O 2 . Accumulation of Mo-rich phase, presumably MoO 3 , in the thick silica layer was readily seen at 723 K.
- Published
- 1999
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20. 'Inverted Twinning' in Intergrowth Tungsten Bronzes
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L. Kihlborg and M. Sundberg
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Chemistry ,Hexagonal crystal system ,chemistry.chemical_element ,General Medicine ,Crystal structure ,engineering.material ,Tungsten ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Crystallography ,law ,engineering ,Bronze ,Electron microscope ,Crystal twinning - Abstract
A new type of twinning occurring in intergrowth tungsten bronzes (ITB) is described, revealed by high-resolution electron microscopy. Across the twin boundary the two structure elements of hexagonal tungsten bronze- and tetragonally distorted ReO3-types are interchanged and grow in strict geometrical relationship to each other. The structure is thus `inverted' and in the general case the two `twin' parts represent different members of the structure family. Some members remain invariant upon inversion, however. This defect is most often seen as ribbons in an ITB matrix in Mo-doped samples Cs x Mo y Wl−y O3, which require a lower synthesis temperature than pure tungsten bronzes. They may be frozen-in stages of a slow ordering process. A similar type of twinning might be found in other intergrowth structures.
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- 1997
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21. On the microstructure of a high-pressure phase of W3O8
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V. P. Filonenko, P.-E. Werner, I. P. Zibrov, D. Louër, and M. Sundberg
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Radiation ,Materials science ,Phase (matter) ,General Materials Science ,Composite material ,Condensed Matter Physics ,Microstructure ,Instrumentation - Abstract
The structures of two high-pressure tungsten oxides, previously studied by high-resolution electron microscopy, were confirmed by Rietveld refinement based on X-ray powder diffraction data. The phases have identical stoichiometry, W3O8, and extremely narrow 00l reflections in common. The microstructure of the dominant phase was investigated by means of X-ray powder diffraction pattern decomposition. A Williamson–Hall plot revealed that all lines, except the 00l reflections, were broadened solely due to the crystallite size effect. A cylindrical model is used to describe the average form of the coherently diffracting domains. The height of the cylinder, whose axis is colinear with the crystallographic c parameter of both phases, is considered “infinite,” and the average diameter of the cylinder model is 655(22) Å. A quantitative confirmation is obtained from electron microscopy.
- Published
- 1995
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22. Effect of moderate ethanol intake on the heart: biochemical and morphological studies with isolated cardiomyocytes from rats fed a low-protein diet
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Péter Sótonyi, Bo Andersson, M Sundberg, J Rajs, and B Lind
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Male ,medicine.medical_specialty ,Alcohol Drinking ,medicine.medical_treatment ,Medicine (miscellaneous) ,Poison control ,Cell morphology ,Mitochondria, Heart ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Low-protein diet ,Internal medicine ,Diet, Protein-Restricted ,medicine ,Animals ,Myocyte ,General Psychology ,Ion Transport ,Ethanol ,Glycogen ,Nucleotides ,Chemistry ,Myocardium ,Heart ,Rats ,Surgery ,Cytosol ,Glucose ,Digitonin ,Endocrinology ,Liver ,Heart Function Tests ,Energy Metabolism - Abstract
It has been shown that chronic consumption of ethanol can impair myocardial function and result in morphological changes of the heart. The purpose of this work was to evaluate relations between changes in energy metabolism and changes of cell morphology.Long-term effects of moderate ethanol consumption on the heart were examined in isolated cardiomyocytes from rats fed a pellet with low-protein content for 6 months. Digitonin treatment of the cardiomyocytes was used to separate mitochondrial and cytosolic fractions.A greater fraction of contracted myocytes was isolated from ethanol- and glucose-treated rats, than from rats fed only glucose and/or water as liquid supplement. There were changes of the ultrastructure of myocytes from ethanol and glucose-treated rats, which included mitochondrial degeneration, accumulation of fat droplets and depletion of the glycogen content. An elevated cytosolic level of nucleotides (ATP, ADP and NAD) and disappearance of magnesium from the mitochondrial fraction were observed in myocytes from rats fed ethanol and glucose. The release of adenosine was also found to be inhibited in these cells.Our results show that moderate ethanol consumption by rats during protein-restricted conditions produces subclinical changes of cardiomyocyte ultrastructure and alteration of cell morphology. Furthermore, the results indicate that changes of the energy homeostasis in myocytes and inhibition of sarcolemmal adenosine transport are early events that appear to precede the histological alterations.
- Published
- 1995
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23. X-ray powder crystal structure analysis of high pressure tungsten dioxide. On the information in weak reflections
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I. P. Zibrov, Per-Erik Werner, and M. Sundberg
- Subjects
Rietveld refinement ,X-ray ,chemistry.chemical_element ,Crystal structure ,Tungsten ,Condensed Matter Physics ,Inorganic Chemistry ,Crystallography ,Octahedron ,chemistry ,Rutile ,Group (periodic table) ,General Materials Science ,Powder diffraction - Abstract
A high-pressure modification of tungsten dioxide (hp-WO2) was synthesized at 80 kbar and 1120 K. The structure was determined from X-ray powder diffraction data: hp-WO2, M = 215.85, space group Pnma, a = 9.7164(3) Å, b = 8.4380(3) Å, c = 4.7564(2) Å, Z = 12, D x = 11.03 g cm−3, Rwp = 0.12 and RB = 0.078 from Rietveld refinement. Although the heavy atom structure may be reasonably well described in space group Cmcm, the total structure can only be described in Pnma. The important information contained in non observable and very weak reflections is discussed. In the hp-WO2, modification the W atoms occupy half of the octahedral interstices of an hcp arrangement of oxygen atoms. It can be described as a distorted rutile structure which is twinned at the unit cell level. An essential feature is that groups of three edge-sharing WO6 octahedra are formed at twin planes. The relation between the ambient-pressure (distorted rutile type) and the high pressure modifications is discussed.
- Published
- 1994
- Full Text
- View/download PDF
24. Diffraction Studies of LaGaO3
- Author
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M. Westdahl, K. Mazur, P.-E. Werner, and M. Sundberg
- Subjects
Diffraction ,Optics ,Materials science ,Mechanics of Materials ,business.industry ,Mechanical Engineering ,General Materials Science ,Selected area diffraction ,Condensed Matter Physics ,business ,Electron backscatter diffraction - Published
- 1994
- Full Text
- View/download PDF
25. Organogenesis of Fascicled ear mutant inflorescences in maize (Poaceae)
- Author
-
A, Orr, G, Haas, and M, Sundberg
- Abstract
The ontogeny of staminate tassels and pistillate ears in the maize mutant Fascicled ear was examined using scanning electron microscopy. The normal pattern of inflorescence development is perturbed by the Fascicled ear mutation at the transition stage. The Fascicled ear mutation promotes the development of an abnormal transition stage axis that is both shorter and broader than the wild type. The inflorescence apical meristem then undergoes a bifurcation, and two inflorescence axes arise in place of a single axis. Each derived inflorescence apical meristem may undergo a similar perturbation sequence. This expression of the Fascicled ear mutation may be repeated one to several times, which leads to the development of a fascicled pistillate inflorescence and a fascicled central spike in the staminate inflorescence. The apical meristems of some tassel branches are also bifurcated. Subsequent organogenesis during paired-spikelet and floral development in Fascicled ear plants follows the pattern of normal maize. However, triplet spikelets are occasionally observed. The organogenic disruption by the Fascicled ear mutation that we describe will aid genetic and molecular analysis on the regulation of inflorescence development in maize and other members of the genus Zea.
- Published
- 2011
26. ChemInform Abstract: New Complex Uranium-Molybdenum Oxides with Intergrowth Structures: An HREM Study
- Author
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B.-O. Marinder and M. Sundberg
- Subjects
chemistry ,Molybdenum ,Metallurgy ,chemistry.chemical_element ,Nanotechnology ,General Medicine ,Uranium - Published
- 2010
- Full Text
- View/download PDF
27. ChemInform Abstract: Crystal Structures of UMo5O16 and U0.75Mo5O16: Studies by X-Ray Diffraction and High-Resolution Electron Microscopy
- Author
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M. Sundberg, V. V. Tabachenko, and O. G. D’yachenko
- Subjects
Crystallography ,High resolution electron microscopy ,Chemistry ,X-ray crystallography ,General Medicine ,Crystal structure - Published
- 2010
- Full Text
- View/download PDF
28. In vivo longitudinal MRI and behavioral studies in experimental spinal cord injury
- Author
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Laura M. Sundberg, Juan J. Herrera, and Ponnada A. Narayana
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Motor Activity ,Nerve Fibers, Myelinated ,Lesion ,White matter ,Rats, Sprague-Dawley ,In vivo ,Behavioral study ,Glial Fibrillary Acidic Protein ,medicine ,Multiple time ,Animals ,Spinal cord injury ,Spinal Cord Injuries ,medicine.diagnostic_test ,Behavior, Animal ,business.industry ,Laminectomy ,Magnetic resonance imaging ,Recovery of Function ,Original Articles ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Rats ,medicine.anatomical_structure ,Spinal Cord ,Neurology (clinical) ,medicine.symptom ,Nuclear medicine ,business ,Psychology ,Diffusion MRI - Abstract
Comprehensive in vivo longitudinal studies that include multi-modal magnetic resonance imaging (MRI) and a battery of behavioral assays to assess functional outcome were performed at multiple time points up to 56 days post-traumatic spinal cord injury (SCI) in rodents. The MRI studies included high-resolution structural imaging for lesion volumetry, and diffusion tensor imaging (DTI) for probing the white matter integrity. The behavioral assays included open-field locomotion, grid walking, inclined plane, computerized activity box performance, and von Frey filament tests. Additionally, end-point histology was assessed for correlation with both the MRI and behavioral data. The temporal patterns of the lesions were documented on structural MRI. DTI studies showed significant changes in white matter that is proximal to the injury epicenter and persisted to day 56. White matter in regions up to 1 cm away from the injury epicenter that appeared normal on conventional MRI also exhibited changes that were indicative of tissue damage, suggesting that DTI is a more sensitive measure of the evolving injury. Correlations between DTI and histology after SCI could not be firmly established, suggesting that injury causes complex pathological changes in multiple tissue components that affect the DTI measures. Histological evidence confirmed a significant decrease in myelin and oligodendrocyte presence 56 days post-SCI. Multiple assays to evaluate aspects of functional recovery correlated with histology and DTI measures, suggesting that damage to specific white matter tracts can be assessed and tracked longitudinally after SCI.
- Published
- 2010
29. Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander
- Author
-
L, Mattsson, T, Lundgren, P, Olsson, M, Sundberg, and J, Lidholm
- Subjects
Adult ,Male ,Base Sequence ,Sequence Homology, Amino Acid ,Immunoblotting ,Molecular Sequence Data ,Allergens ,Cross Reactions ,Immunoglobulin E ,Middle Aged ,Chromatography, Ion Exchange ,Receptors, Odorant ,Young Adult ,Dogs ,Sequence Homology, Nucleic Acid ,Hypersensitivity ,Animals ,Humans ,Cattle ,Female ,Amino Acid Sequence - Abstract
Dog dander is an important cause of respiratory allergy but its content of allergenic components is still incompletely known. While Can f 1, 2, 3 and 5 have been studied in detail, only fragmentary information is available on the lipocalin Can f 4.To purify, clone and characterize dog dander allergen Can f 4.Can f 4 was purified from dog dander extract by size exclusion, ion exchange and reverse phase chromatography. A cDNA encoding Can f 4 was cloned and used to produce recombinant Can f 4 in Escherichia coli. A 23 kDa protein from cow dander, displaying cross-reactivity with Can f 4, was purified and identified by amino acid sequencing and mass spectrometry. IgE antibody binding to dog and cow dander extract and to individual dog allergens among 37 dog allergic subjects and 44 pollen allergic controls was studied using ImmunoCAP.A dog genome segment containing the Can f 4 gene was bioinformatically identified and enabled the cloning of Can f 4 cDNA. Recombinant Can f 4 displayed close immunological and biochemical similarity to purified natural Can f 4 and bound IgE antibodies from 13/37 (35%) sera of dog allergic subjects. Can f 4 reactive sera showed IgE binding to a 23 kDa protein present in cow dander extract, related to a family of odorant-binding proteins. The dog and cow proteins shared 37% sequence identity and their cross-reactivity was demonstrated by IgE inhibition experiments.Recombinant Can f 4 brings the panel of available dog allergens closer to completion and will be important in component-resolved diagnostics in allergy to animal epithelial allergens.
- Published
- 2010
30. Effect of VEGF Treatment on the Blood-Spinal Cord Barrier Permeability in Experimental Spinal Cord Injury: Dynamic Contrast-Enhanced Magnetic Resonance Imaging
- Author
-
David M. Cohen, Pallavi Ahobila-Vajjula, Ponnada A. Narayana, Laura M. Sundberg, Tessy Chacko, and Chirag B. Patel
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Pathology ,medicine.medical_specialty ,Cord ,Angiogenesis ,Vascular permeability ,Motor Activity ,Blood–brain barrier ,Models, Biological ,Permeability ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,medicine ,Animals ,Spinal cord injury ,Spinal Cord Injuries ,Analysis of Variance ,business.industry ,Original Articles ,Spinal cord ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Rats ,Vascular endothelial growth factor ,medicine.anatomical_structure ,chemistry ,Spinal Cord ,Permeability (electromagnetism) ,Blood-Brain Barrier ,Anesthesia ,Neurology (clinical) ,business - Abstract
Compromised blood-spinal cord barrier (BSCB) is a factor in the outcome following traumatic spinal cord injury (SCI). Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis and vascular permeability. The role of VEGF in SCI is controversial. Relatively little is known about the spatial and temporal changes in the BSCB permeability following administration of VEGF in experimental SCI. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) studies were performed to noninvasively follow spatial and temporal changes in the BSCB permeability following acute administration of VEGF in experimental SCI over a post-injury period of 56 days. The DCE-MRI data was analyzed using a two-compartment pharmacokinetic model. Animals were assessed for open field locomotion using the Basso-Beattie-Bresnahan score. These studies demonstrate that the BSCB permeability was greater at all time points in the VEGF-treated animals compared to saline controls, most significantly in the epicenter region of injury. Although a significant temporal reduction in the BSCB permeability was observed in the VEGF-treated animals, BSCB permeability remained elevated even during the chronic phase. VEGF treatment resulted in earlier improvement in locomotor ability during the chronic phase of SCI. This study suggests a beneficial role of acutely administered VEGF in hastening neurobehavioral recovery after SCI.
- Published
- 2009
31. [New typing of hepatitis B virus improves transmission monitoring. Prospective molecular typing shows increased sexual transmission]
- Author
-
Karin M, Sundberg, Karin, Restorp, Madeleinen, Von Sydow, Mona, Insulander, Heléne, Norder, and Lars, Magnius
- Subjects
Male ,Sweden ,Hepatitis B virus ,Genotype ,Homosexuality ,Sexually Transmitted Diseases, Viral ,Global Health ,Hepatitis B ,Molecular Diagnostic Techniques ,Risk Factors ,Acute Disease ,Carrier State ,Communicable Disease Control ,Prevalence ,Humans ,Female ,Contact Tracing ,Serotyping ,Heterosexuality ,Substance Abuse, Intravenous - Published
- 2009
32. Comparison of Current Interruption and Electrochemical Impedance Techniques in the Determination of Corrosion Rates of Steel in Concrete
- Author
-
Kathleen M. Sundberg, Ding Feng Shen, and Neal S. Berke
- Subjects
Materials science ,Working electrode ,Metallurgy ,Electrolyte ,Polarization (electrochemistry) ,Electrical impedance ,Reference electrode ,Ohmic contact ,Durability ,Corrosion - Abstract
Steel reinforced concrete is a widely used construction material. It is often the material of choice in bridges, parking garages, and marine structures because of its good durability and resistance to corrosion. However, over time, even well designed concrete is susceptible to chloride intrusion from deicing or marine salts or both, resulting in corrosion of embedded steel. By the time corrosion of steel in concrete is readily noticeable, major repairs are often required. A nondestructive means of determining the corrosion rate of inaccessible steel is thus needed. Electrochemical techniques such as polarization resistance are useful, however resistivities of concrete range from 1000 to greater than 30 000 ohm-cm. Furthermore, reference electrodes are usually greater than 25 mm from the working electrode (rebars). Thus, large ohmic electrolyte resistance is present, even at the low current densities associated with steel in concrete, and must be accounted for to accurately measure corrosion rates. In this paper we compare the use of current interruption correction for ohmic resistance to an electrochemical impedance measurement at 20 KHz. In general, we find a good correlation between the two techniques, and demonstrate that substantial ohmic resistances are present.
- Published
- 2009
- Full Text
- View/download PDF
33. Rectifying metal/poly(3-hexylthiophene) contacts
- Author
-
Göran Gustafsson, Olle Inganäs, Christer Svensson, and M. Sundberg
- Subjects
chemistry.chemical_classification ,Materials science ,Dopant ,business.industry ,Mechanical Engineering ,Metals and Alloys ,Oxide ,chemistry.chemical_element ,Thermionic emission ,Polymer ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Metal ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Aluminium ,Homogeneous ,visual_art ,Electric field ,Materials Chemistry ,visual_art.visual_art_medium ,Optoelectronics ,business - Abstract
Rectifying contacts between poly(3-hexylthiophene) and Indium-Tin oxide or Aluminum have been studied by means of current-voltage measurements and capacitance-voltage measurements. The results show that the current transport through these contacts is not well described by conventional thermionic emission theory. Furthermore, the dopant distribution is not homogeneous in the polymer. Dopants accumulate near the polymer/metal interface. This accumulation can be enhanced by means of an electric field applied across the structure.
- Published
- 1991
- Full Text
- View/download PDF
34. Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI
- Author
-
David M, Cohen, Chirag B, Patel, Pallavi, Ahobila-Vajjula, Laura M, Sundberg, Tessy, Chacko, Shi-Jie, Liu, and Ponnada A, Narayana
- Subjects
Male ,Time Factors ,Contrast Media ,Reproducibility of Results ,Gadolinium ,Sodium Chloride ,Magnetic Resonance Imaging ,Permeability ,Article ,Rats ,Rats, Sprague-Dawley ,Spinal Cord ,Blood-Brain Barrier ,Albumins ,Animals ,skin and connective tissue diseases ,Spinal Cord Injuries ,Extravasation of Diagnostic and Therapeutic Materials - Abstract
Following the primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood-spinal cord-barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)studies were performed up to 56 days post-SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI(non-enhancing tissue). DCE-MRI data was analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. But, based on DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days post-SCI. In addition, open-field locomotion was evaluated using the 21 point Basso-Beattie-Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed.
- Published
- 2008
35. Deacetylation of xylans by acetyl esterases of Trichoderma reesei
- Author
-
Jürgen Puls, Kaisa Poutanen, M. Sundberg, and H. Korte
- Subjects
animal structures ,biology ,technology, industry, and agriculture ,food and beverages ,General Medicine ,Acetylesterase ,macromolecular substances ,Xylose ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Xylan ,carbohydrates (lipids) ,chemistry.chemical_compound ,chemistry ,Acetylation ,Xylanase ,Xylobiose ,Organic chemistry ,Acetylxylan esterase ,Trichoderma reesei ,Biotechnology - Abstract
Two previously purified esterases of Trichoderma reesei were used to study the deacetylation of polymeric, oligomeric and dimeric acetylated xylan fragments. For the first time nearly complete enzymatic deacetylation of polymeric xylan with purified acetyl xylan esterase was demonstrated, resulting in precipitation of the remaining polymer structure. The esterases had very different substrate specifities, one having a preference for high molecular weight substrates and the other showing high activity only towards acetyl xylobiose. The latter enzyme was also regioselective, cleaving off the acetyl substituent only from the C-3 position of the xylopyranose ring. The highest xylose yield from acetylated xylan was obtained by the synergistic action of xylanase, \-xylosidase and acetyl xylan esterase.
- Published
- 1990
- Full Text
- View/download PDF
36. Authors’ reply
- Author
-
M. SUNDBERG, J. BESKAJOV, T. VON SCHEWELOW, and å. CARLSSON
- Subjects
Orthopedics and Sports Medicine ,Surgery - Published
- 2006
- Full Text
- View/download PDF
37. Regional differences in the incidence of insulin-dependent diabetes mellitus among children in Finland from 1987 to 1991. Childhood Diabetes in Finland (DiMe) Study Group
- Author
-
M, Karvonen, J, Rusanen, M, Sundberg, E, Virtala, A, Colpaert, A, Naukkarinen, and J, Tuomilehto
- Subjects
Diabetes Mellitus, Type 1 ,Adolescent ,Incidence ,Urbanization ,Odds Ratio ,Humans ,Child ,Finland - Abstract
The regional pattern of insulin-dependent diabetes mellitus (IDDM) incidence among children in Finland was analysed applying several methods attempting to describe the geographical variation in occurrence of IDDM. From 1987 to 1991 the number of newly diagnosed cases aged 14 years or less at diagnosis was 1728. The incidence, the incidence rate ratio and the Bayes relative risk (RR) for IDDM were calculated by municipality, by functional area (an urban centre with a subordinated surrounding area) and by area with a population of equal size at risk employing the Geographical Information Systems. The association of IDDM incidence with the degree of urbanization was assessed using the population density as a criterion for the degree of urbanization. The overall mean of the IDDM incidence was 35 per 100000 persons per year. Between municipalities the incidence varied from 4 to 245 per 100000 persons per year, whereas a clear regional pattern was seen among the functional areas and the incidence varied from 26 to 43 per 100000 persons per year. The RR for IDDM among the municipalities ranged from 0.82 to 1.34 and from 0.73 to 1.27 among the functional areas. The incidence determined in four zones with the same size of population was the highest in the middle part of the country. There was a strong inverse correlation between population density and the incidence of IDDM and this also applied to the relationship between child population density and incidence.
- Published
- 1997
38. [A study of handicapped children demanding prolonged care. Their survival depends on technology]
- Author
-
H, Ferngren, H, Feychting, and M, Sundberg
- Subjects
Male ,Sweden ,Brain Diseases ,Adolescent ,Genetic Diseases, Inborn ,Infant, Newborn ,Infant ,Length of Stay ,Intensive Care Units, Pediatric ,Congenital Abnormalities ,Child, Preschool ,Intensive Care Units, Neonatal ,Medical Laboratory Science ,Humans ,Disabled Persons ,Female ,Child - Published
- 1997
39. [Technology-dependent children with prolonged care. Cooperation within home care services prevents parents' stress]
- Author
-
H, Ferngren, H, Feychting, and M, Sundberg
- Subjects
Adult ,Parents ,Adolescent ,Home Nursing ,Infant, Newborn ,Infant ,Social Support ,Home Care Services ,Patient Education as Topic ,Child, Preschool ,Surveys and Questionnaires ,Infant Care ,Medical Laboratory Science ,Humans ,Disabled Persons ,Child Care ,Child ,Stress, Psychological - Published
- 1997
40. PP096-MON DO WE MEET THE NUTRITIONAL GOALS FOR INPATIENTS? RESULTS FROM A ONE-DAY SURVEY AT UPPSALA UNIVERSITY HOSPITAL
- Author
-
Wegener, S., primary, Hjelm, M. Sundberg, additional, Åkerlind, L., additional, Wahlroth, K., additional, and Rodebjer, S., additional
- Published
- 2012
- Full Text
- View/download PDF
41. PP096-MON DO WE MEET THE NUTRITIONAL GOALS FOR INPATIENTS? RESULTS FROM A ONE-DAY SURVEY AT UPPSALA UNIVERSITY HOSPITAL
- Author
-
K. Wahlroth, S. Rodebjer, S. Wegener, M. Sundberg Hjelm, and L. Åkerlind
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Family medicine ,Medicine (miscellaneous) ,Medicine ,Critical Care and Intensive Care Medicine ,University hospital ,business - Published
- 2012
- Full Text
- View/download PDF
42. Effects of Calcium Nitrite and Microsilica Admixtures on Corrosion Resistance of Steel in Concrete
- Author
-
K. M Sundberg and N. S. Berke
- Subjects
chemistry.chemical_compound ,Materials science ,Silica fume ,chemistry ,Diffusion ,Metallurgy ,Calcium nitrite ,Composite material ,Reinforced concrete ,Corrosion - Published
- 1990
- Full Text
- View/download PDF
43. ENZYMATIC SOLUBILIZATION OF XYLANS
- Author
-
M. Sundberg, Kaisa Poutanen, M. Rättö, Jürgen Puls, and M. J. Bailey
- Subjects
Biochemistry ,Solubilization ,Chemistry - Published
- 1990
- Full Text
- View/download PDF
44. [P53]: Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through regulation of Cyclin D1
- Author
-
Dan Lindholm, L. Korhonen, and M. Sundberg
- Subjects
Endothelial stem cell ,Cyclin D1 ,Developmental Neuroscience ,Cell growth ,Neurosphere ,Biology ,Glucocorticoid hormones ,Embryonic stem cell ,Neural stem cell ,Developmental Biology ,Adult stem cell ,Cell biology - Published
- 2006
- Full Text
- View/download PDF
45. A Group-based Patient Education Programme for High-Anxiety Patients with Crohn Disease or Ulcerative Colitis
- Author
-
K., Larsson, primary, M., Sundberg Hjelm, additional, U., Karlbom, additional, K., Nordin, additional, M., Anderberg U., additional, and L., Lööf, additional
- Published
- 2003
- Full Text
- View/download PDF
46. Rectifying metal‐polymer contacts formed by melt processing
- Author
-
Göran Gustafsson, Olle Inganäs, and M. Sundberg
- Subjects
chemistry.chemical_classification ,Conductive polymer ,Materials science ,Physics and Astronomy (miscellaneous) ,chemistry.chemical_element ,Polymer ,Metal ,chemistry ,Sputtering ,Aluminium ,visual_art ,Melting point ,visual_art.visual_art_medium ,Composite material ,Indium ,Titanium - Abstract
Rectifying contacts between aluminum, indium, or titanium and a solution and melt processable conducting polymer, poly(3‐octylthiophene) have been formed by melt processing. The contacts are formed by heating a metal/polymer/metal structure to the melting point of the polymer and then pressing the metals to the melted polymer until adhesion is achieved, whereupon the whole structure is cooled to room temperature. Comparison of the current‐voltage and capacitance‐voltage characteristics of a melt processed device and a device manufactured by metal sputtering shows that no significant differences exist between these structures.
- Published
- 1990
- Full Text
- View/download PDF
47. Sustained Expression of Vascular Endothelial Growth Factor and Angiopoietin-1 Improves Blood–Spinal Cord Barrier Integrity and Functional Recovery after Spinal Cord Injury.
- Author
-
Juan J. Herrera, Laura M. Sundberg, Lorena Zentilin, Mauro Giacca, and Ponnada A. Narayana
- Subjects
- *
GENE expression , *VASCULAR endothelial growth factors , *SPINAL cord injuries , *NEOVASCULARIZATION , *HEALTH outcome assessment , *MAGNETIC resonance imaging of the brain , *WESTERN immunoblotting , *MICROGLIA , *COMBINED modality therapy - Abstract
AbstractSpinal cord injury (SCI) results in immediate disruption of the spinal vascular network, triggering an ischemic environment and initiating secondary degeneration. Promoting angiogenesis and vascular stability through the induction of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1), respectively, provides a possible therapeutic approach in treating SCI. We examined whether supplementing the injured environment with these two factors, which are significantly reduced following injury, has an effect on lesion size and functional outcome. Sustained delivery of both VEGF165and Ang-1 was realized using viral vectors based on the adeno-associated virus (AAV), which were injected directly into the lesion epicenter immediately after injury. Our results indicate that the combined treatment with VEGF and Ang-1 resulted in both reduced hyperintense lesion volume and vascular stabilization, as determined by magnetic resonance imaging (MRI). Western blot analysis indicated that the viral vector expression was maintained into the chronic phase of injury, and that the use of the AAV vectors did not exacerbate infiltration of microglia into the lesion epicenter. The combined treatment with AAV-VEGF and AAV-Ang-1 improved locomotor recovery in the chronic phase of injury. These results indicate that combining angiogenesis with vascular stabilization may have potential therapeutic applications following SCI. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
48. In VivoLongitudinal MRI and Behavioral Studies in Experimental Spinal Cord Injury.
- Author
-
Laura M. Sundberg, Juan J. Herrera, and Ponnada A. Narayana
- Subjects
- *
LONGITUDINAL method , *EXPERIMENTAL design , *SPINAL cord injuries , *MAGNETIC resonance imaging of the brain , *HEALTH outcome assessment , *LABORATORY rodents , *MEDICAL imaging systems - Abstract
AbstractComprehensive in vivolongitudinal studies that include multi-modal magnetic resonance imaging (MRI) and a battery of behavioral assays to assess functional outcome were performed at multiple time points up to 56 days post-traumatic spinal cord injury (SCI) in rodents. The MRI studies included high-resolution structural imaging for lesion volumetry, and diffusion tensor imaging (DTI) for probing the white matter integrity. The behavioral assays included open-field locomotion, grid walking, inclined plane, computerized activity box performance, and von Frey filament tests. Additionally, end-point histology was assessed for correlation with both the MRI and behavioral data. The temporal patterns of the lesions were documented on structural MRI. DTI studies showed significant changes in white matter that is proximal to the injury epicenter and persisted to day 56. White matter in regions up to 1 cm away from the injury epicenter that appeared normal on conventional MRI also exhibited changes that were indicative of tissue damage, suggesting that DTI is a more sensitive measure of the evolving injury. Correlations between DTI and histology after SCI could not be firmly established, suggesting that injury causes complex pathological changes in multiple tissue components that affect the DTI measures. Histological evidence confirmed a significant decrease in myelin and oligodendrocyte presence 56 days post-SCI. Multiple assays to evaluate aspects of functional recovery correlated with histology and DTI measures, suggesting that damage to specific white matter tracts can be assessed and tracked longitudinally after SCI. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
49. Vascular Endothelial Growth Factor and Spinal Cord Injury Pain.
- Author
-
Olivera Nesic, Laura M. Sundberg, Juan J. Herrera, Venkata U.L. Mokkapati, Julieann Lee, and Ponnada A. Narayana
- Subjects
- *
VASCULAR endothelial growth factors , *SPINAL cord injuries , *GENETIC regulation , *GENETIC transcription , *LABORATORY rats , *AXONS - Abstract
AbstractVascular endothelial growth factor (VEGF)-A mRNA was previously identified as one of the significantly upregulated transcripts in spinal cord injured tissue from adult rats that developed allodynia. To characterize the role of VEGF-A in the development of pain in spinal cord injury (SCI), we analyzed mechanical allodynia in SCI rats that were treated with either vehicle, VEGF-A isoform 165 (VEGF165), or neutralizing VEGF165-specific antibody. We have observed that exogenous administration of VEGF165increased both the number of SCI rats that develop persistent mechanical allodynia, and the level of hypersensitivity to mechanical stimuli. Our analysis identified excessive and aberrant growth of myelinated axons in dorsal horns and dorsal columns of chronically injured spinal cords as possible mechanisms for both SCI pain and VEGF165-induced amplification of SCI pain, suggesting that elevated endogenous VEGF165may have a role in the development of allodynia after SCI. However, the neutralizing VEGF165antibody showed no effect on allodynia or axonal sprouting after SCI. It is possible that another endogenous VEGF isoform activates the same signaling pathway as the exogenously-administered 165 isoform and contributes to SCI pain. Our transcriptional analysis revealed that endogenous VEGF188is likely to be the isoform involved in the development of allodynia after SCI. To the best of our knowledge, this is the first study to suggest a possible link between VEGF, nonspecific sprouting of myelinated axons, and mechanical allodynia following SCI. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
50. Effect of VEGF Treatment on the Blood-Spinal Cord Barrier Permeability in Experimental Spinal Cord Injury: Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
- Author
-
Chirag B. Patel, David M. Cohen, Pallavi Ahobila-Vajjula, Laura M. Sundberg, Tessy Chacko, and Ponnada A. Narayana
- Published
- 2009
- Full Text
- View/download PDF
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