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4. Measurements of higher-order cumulants of multiplicity and net-electric charge distributions in inelastic proton–proton interactions by NA61/SHINE

Author

NA61/SHINE Collaboration, H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, I.-C. Arsene, M. Bajda, Y. Balkova, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, A. Borucka, A. Brandin, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, A. Dmitriev, P. von Doetinchem, W. Dominik, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, R. Kolesnikov, D. Kolev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, A. Olivier, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, D. Rybka, K. Sakashita, K. Schmidt, A. Yu. Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, Ł. Świderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, D. Veberič, V. V. Vechernin, O. Vitiuk, V. Volkov, A. Wickremasinghe, K. Witek, K. Wójcik, O. Wyszyński, A. Zaitsev, E. Zherebtsova, E. D. Zimmerman, A. Zviagina, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract This paper presents the energy dependence of multiplicity and net-electric charge fluctuations in p+p interactions at beam momenta 20, 31, 40, 80, and 158 $$\text{ Ge }\hspace{-1.00006pt}\text{ V }\!/\!c$$ Ge V / c . Results are corrected for the experimental biases and quantified with the use of cumulants and factorial cumulants. Cumulant ratios are an essential tool in the search for the critical point of strongly interacting matter in heavy ion collisions. Measurements performed in p+p interactions provide a vital baseline estimation in these studies. The measured signals are compared with the string hadronic models Epos1.99 and FTFP-BERT.

Published
2024
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5. $$K^0_S$$ K S 0 meson production in inelastic p+p interactions at 31, 40 and 80 $$\text {Ge}\hspace{-1.00006pt}\text {V}\!/\!c$$ Ge V / c beam momentum measured by NA61 $$/$$ / SHINE at the CERN SPS

Author

NA61/SHINE Collaboration, N. Abgrall, H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I.-C. Arsene, M. Bajda, Y. Balkova, M. Baszczyk, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, A. Dmitriev, P. von Doetinchem, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, K. Kadija, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, H. Kitagawa, R. Kolesnikov, D. Kolev, A. Korzenev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, A. Morawiec, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, K. Sakashita, K. Schmidt, A. Yu. Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, L. Swiderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The yields of $$K^0_S$$ K S 0 mesons have been measured in inelastic p+p interactions at incident projectile momenta of 31, 40 and 80 $$\text {Ge}\hspace{-1.00006pt}\text {V}\!/\!c$$ Ge V / c ( $$\sqrt{s_{NN}}=7.7, 8.8$$ s NN = 7.7 , 8.8 and 12.3 $$\text {Ge}\hspace{-1.00006pt}\text {V}$$ Ge V , respectively). The data were recorded by the NA61 $$/$$ / SHINE spectrometer at the CERN Super Proton Synchrotron and the $$K^0_S$$ K S 0 mesons identified via their decays into $$\pi ^{+} \pi ^{-}$$ π + π - pairs. Double-differential distributions are presented as function of transverse momentum and rapidity. The mean multiplicities of $$K^0_S$$ K S 0 mesons were determined to be $$(5.95 \pm 0.19 (stat) \pm 0.30 (sys)) \times 10^{-2}$$ ( 5.95 ± 0.19 ( s t a t ) ± 0.30 ( s y s ) ) × 10 - 2 at 31 $$\text {Ge}\hspace{-1.00006pt}\text {V}\!/\!c$$ Ge V / c , $$(7.61 \pm 0.13 (stat) \pm 0.43 (sys)) \times 10^{-2}$$ ( 7.61 ± 0.13 ( s t a t ) ± 0.43 ( s y s ) ) × 10 - 2 at 40 $$\text {Ge}\hspace{-1.00006pt}\text {V}\!/\!c$$ Ge V / c and $$(11.58 \pm 0.12 (stat) \pm 0.55 (sys)) \times 10^{-2}$$ ( 11.58 ± 0.12 ( s t a t ) ± 0.55 ( s y s ) ) × 10 - 2 at 80 $$\text {Ge}\hspace{-1.00006pt}\text {V}\!/\!c$$ Ge V / c . The results on $$K^{0}_{S}$$ K S 0 production are compared with the production of charged kaons in corresponding reactions and with model calculations (Epos1.99, SMASH 2.0 and PHSD) as well as with published data from other experiments.

Published
2024
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6. Search for a critical point of strongly-interacting matter in central $$^{40}$$ 40 Ar + $$^{45}$$ 45 Sc collisions at 13 A–75 A GeV/c beam momentum

Author

NA61/SHINE Collaboration, H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I.-C. Arsene, M. Bajda, Y. Balkova, M. Baszczyk, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, P. Christakoglou, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, F. Diakonos, A. Dmitriev, P. von Doetinchem, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, K. Kadija, A. Kapoyannis, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, H. Kitagawa, R. Kolesnikov, D. Kolev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A.D. Marino, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, A. Morawiec, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, V. Ozvenchuk, A. D. Panagiotou, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, K. Sakashita, K. Schmidt, A. Yu Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, L. Swiderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, M. Vassiliou, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The critical point of strongly interacting matter is searched for at the CERN SPS by the NA61/SHINE experiment in central $$^{40}$$ 40 Ar + $$^{45}$$ 45 Sc collisions at 13 A, 19 A, 30 A, 40 A, and 75 A GeV/c. The dependence of the second-order scaled factorial moments of proton multiplicity distributions on the number of subdivisions in transverse momentum space is measured. The intermittency analysis uses statistically independent data sets for every subdivision in transverse and cumulative-transverse momentum variables. The results obtained do not indicate the searched intermittent pattern. An upper limit on the fraction of correlated protons and the intermittency index is obtained based on a comparison with the Power-law Model.

Published
2024
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7. Hypofractionnement extrême en pratique : les nouvelles indications dans les cancers du sein

Author

M. Ung, G. Auzac, Sofia Rivera, T. Brion, K. Berthelot, G. Louvel, S. Bockel, C. Milewski, and F. Villaret

Subjects
Oncology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Significant difference, Partial Breast Irradiation, medicine.disease, Partial breast, law.invention, Radiation therapy, Regimen, Breast cancer, Whole Breast Irradiation, Randomized controlled trial, law, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business
Abstract

Due to the continuously increasing number of newly diagnosed breast cancer and limited health resources hypofractionated radiotherapy is a major topic. Recent results from randomized clinical trials assessing extreme hypofractionated radiotherapy for whole or partial breast radiotherapy are practice changing. Here we report toxicity and oncological outcomes from major recent trials of extreme hypofractionated breast irradiation and present an ongoing prospective implementation program. For whole breast irradiation, with a 10 years follow up, the UK-FAST trial demonstrated no significant difference in toxicity between a once weekly 5 fractions (5,7Gy/fr) regimen and a conventional 50Gy/25fr regimen. With a 5 years follow up, the FAST-Forward trial showed non inferiority on local control for a 5 fractions over 1 week (5,2Gy/fr) regimen versus standard 40Gy/15fr over 3 weeks with safe toxicity profile. For accelerated partial breast irradiation, in low-risk breast cancers patients, several phase III randomized trials confirmed that extreme hypofractionation is a valid option. With our "One Week Breast Radiotherapy" program, we propose the implementation of a one-week full workflow preparing and delivering 5 fractions over 1 week (26Gy) in selected patients with prospective follow-up. Several extreme hypofractionated breast radiotherapy regimens are validated and can be routinely discussed with patients in a share decision-making process following patient selection criteria and dosimetric constraints.

Published
2021

9. Impact dosimétrique de la pose d’un espaceur rectal dans le traitement de cancer de la prostate localisé par irradiation en conditions stéréotaxiques

Author

V. Anthonipillai, L Abbassi, M. Ung, Alberto Bossi, J. Vautier, Pierre Blanchard, and M. Cheve

Subjects
business.industry, medicine.medical_treatment, Rectum, Mean age, medicine.disease, Radiation therapy, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine.anatomical_structure, Oncology, Rectal wall, 030220 oncology & carcinogenesis, medicine, High doses, Radiology, Nuclear Medicine and imaging, Local anesthesia, Nuclear medicine, business, Stereotactic body radiotherapy
Abstract

Purpose Stereotactic body radiotherapy (SBRT) of prostate cancer is associated with rectal toxicities, which can be reduced by using a hydrogel spacer. The object of this retrospective study was to show the feasibility of spacer placement under local anesthesia and utility of hydrogel spacer to reduce the dose to the rectal wall. Material and methods We collected data from all patients with localised prostate cancer treated with SBRT (40Gy in 5 fractions) between 2018 and 2020. A hydrogel spacer (SpaceOAR®) was placed depending on the availability of the product. We collected dosimetric data for target volumes and organs at risk. We calculated mean values, which were compared using non-parametric tests. Results Among 35 patients, mean age was 75 years. Seventeen had a spacer placed, with a mean space created of 10mm. No complication was reported during the intervention. High doses to the rectal wall were significantly lower in spacer group (V38: 0.39 cm3 vs. 0.72 cm3; P=0.02). PTV were better covered in spacer group (P=0.07). Doses to the bladder wall were similar in both groups. Conclusion Spacer procedure under local anesthesia was well tolerated. Hydrogel spacer allowed to reduce doses to the rectum while improving PTV coverage.

Published
2021

10. Measurements of $$\pi ^\pm $$ π ± , $$K^\pm $$ K ± , p and $$\bar{p}$$ p ¯ spectra in $$^{40}\hbox {Ar+}^{45}\hbox {Sc}$$ 40 Ar+ 45 Sc collisions at 13A to 150A $$\text{ Ge }\hspace{-1.00006pt}\text{ V }\!/\!c$$ Ge V / c

Author

NA61/SHINE Collaboration, H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I.-C. Arsene, M. Bajda, Y. Balkova, M. Baszczyk, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, A. Dmitriev, P. von Doetinchem, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, K. Kadija, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, H. Kitagawa, R. Kolesnikov, D. Kolev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, A. Morawiec, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, K. Sakashita, K. Schmidt, A.Yu. Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, L. Swiderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The NA61/SHINE experiment at the CERN Super Proton Synchrotron studies the onset of deconfinement in strongly interacting matter through a beam energy scan of particle production in collisions of nuclei of varied sizes. This paper presents results on inclusive double-differential spectra, transverse momentum and rapidity distributions and mean multiplicities of $$\pi ^\pm $$ π ± , $$K^\pm $$ K ± , p and $$\bar{p}$$ p ¯ produced in $$^{40}\hbox {Ar+}^{45}\hbox {Sc}$$ 40 Ar+ 45 Sc collisions at beam momenta of 13A, 19A, 30A, 40A, 75A and 150A $$\text{ Ge }\hspace{-1.00006pt}\text{ V }\!/\!c$$ Ge V / c . The analysis uses the 10% most central collisions, where the observed forward energy defines centrality. The energy dependence of the $$K^\pm $$ K ± / $$\pi ^\pm $$ π ± ratios as well as of inverse slope parameters of the $$K^\pm $$ K ± transverse mass distributions are placed in between those found in inelastic $$p+p$$ p + p and central Pb + Pb collisions. The results obtained here establish a system-size dependence of hadron production properties that so far cannot be explained either within statistical or dynamical models.

Published
2024
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11. PD-0731 Improvement of a deep learning based automatic delineation model using anatomical criteria

Author

Sophie Bockel, N. Paragios, G. Auzac, Elaine Johanna Limkin, David Pasquier, Sofia Rivera, E. Karamouza, N. Bonnet, A. Lombard, H. trialists, A. Lamrani-Ghaouti, S. Wong, M. Ung, L. de Vitry, T. Roque, T. Brion, and S. Achkar

Subjects
Oncology, Computer science, business.industry, Deep learning, Radiology, Nuclear Medicine and imaging, Hematology, Artificial intelligence, business, Machine learning, computer.software_genre, computer
Published
2021

12. Shining Light on the Light-Bearing Element: A Brief Review of Photomediated C–H Phosphorylation Reactions

Author

Chao-Jun Li, Sosthène P.-M. Ung, and Victoria Atica Mechrouk

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Aryl, Radical, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Redox, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Nucleophile, chemistry, Reagent, Photocatalysis, Alkyl
Abstract

Organophosphorus compounds have numerous useful applications, from versatile ligands and nucleophiles in the case of trivalent organophosphorus species to therapeutics, agrochemicals and material additives for pentavalent species. Although phosphorus chemistry is a fairly mature field, the construction of C–P(V) bonds relies heavily on either prefunctionalized substrates such as alkyl or aryl halides, or requires previously oxidized bonds such as C=N or C=O, leading to potential sustainability issues when looking at the overall synthetic route. In light of the recent advances in photochemistry, using photons as a reagent can provide better alternatives for phosphorylations by unlocking radical mechanisms and providing interesting redox pathways. This review will showcase the different photomediated phosphorylation procedures available for converting C–H bonds into C–P(V) bonds.1 Introduction1.1 Organophosphorus Compounds1.2 Phosphorylation: Construction of C–P(V) Bonds1.3 Photochemistry as an Alternative to Classical Phosphorylations2 Ionic Mechanisms Involving Nucleophilic Additions3 Mechanisms Involving Radical Intermediates3.1 Mechanisms Involving Reactive Carbon Radicals3.2 Mechanisms Involving Phosphorus Radicals3.2.1 Photoredox: Direct Creation of Phosphorus Radicals3.2.2 Photoredox: Indirect Creation of Phosphorus Radicals3.2.3 Dual Catalysis3.3 Photolytic Cleavage4 Conclusion and Outlook

Published
2020

14. [Extreme hypofractionation: New indications for breast cancer radiotherapy]

Author

S, Bockel, G, Louvel, T, Brion, M, Ung, K, Berthelot, F, Villaret, G, Auzac, C, Milewski, and S, Rivera

Subjects
Time Factors, Treatment Outcome, Clinical Trials, Phase III as Topic, Patient Selection, Humans, Multicenter Studies as Topic, Breast Neoplasms, Female, Radiation Dose Hypofractionation, Equivalence Trials as Topic, Follow-Up Studies, Program Evaluation, Randomized Controlled Trials as Topic
Abstract

Due to the continuously increasing number of newly diagnosed breast cancer and limited health resources hypofractionated radiotherapy is a major topic. Recent results from randomized clinical trials assessing extreme hypofractionated radiotherapy for whole or partial breast radiotherapy are practice changing. Here we report toxicity and oncological outcomes from major recent trials of extreme hypofractionated breast irradiation and present an ongoing prospective implementation program. For whole breast irradiation, with a 10 years follow up, the UK-FAST trial demonstrated no significant difference in toxicity between a once weekly 5 fractions (5,7Gy/fr) regimen and a conventional 50Gy/25fr regimen. With a 5 years follow up, the FAST-Forward trial showed non inferiority on local control for a 5 fractions over 1 week (5,2Gy/fr) regimen versus standard 40Gy/15fr over 3 weeks with safe toxicity profile. For accelerated partial breast irradiation, in low-risk breast cancers patients, several phase III randomized trials confirmed that extreme hypofractionation is a valid option. With our "One Week Breast Radiotherapy" program, we propose the implementation of a one-week full workflow preparing and delivering 5 fractions over 1 week (26Gy) in selected patients with prospective follow-up. Several extreme hypofractionated breast radiotherapy regimens are validated and can be routinely discussed with patients in a share decision-making process following patient selection criteria and dosimetric constraints.

Published
2021

16. Enrollment of older metastatic breast cancer patients in first-line clinical trials: 9-year experience of the large-scale real-life multicenter French ESME cohort

Author

M. Bringuier, M. Carton, C. Levy, A. Patsouris, D. Pasquier, M. Debled, O. Rigal, W. Jacot, A. Gonçalves, I. Desmoulins, T. De La Motte Rouge, T. Bachelot, J.-M. Ferrero, J.-C. Eymard, M. Ung, M.-A. Mouret-Reynier, T. Petit, M. Chevrot, L. Uwer, C. Courtinard, J.-S. Frenel, A. Vianzone, and C. Baldini

Subjects
Cohort Studies, Cancer Research, Oncology, Databases, Factual, Receptor, ErbB-2, Antineoplastic Combined Chemotherapy Protocols, Humans, Breast Neoplasms, Female, Neoplasms, Second Primary, Aged, Retrospective Studies
Abstract

Older cancer patients are underrepresented in clinical trials. We aimed to evaluate the enrollment of older women aged 70 years old (yo) or over with metastatic breast cancer (MBC) in clinical trials.We used the national Epidemio-Strategy and Medical Economics MBC Data Platform, a French multi-center real-life database. We selected MBC women over 70yo, without central nervous system metastases, with at least one line of systemic treatment, between January 1st, 2008 and December 31st, 2016, and had no other cancer in the 5 years before MBC. The primary objective was to evaluate the proportion of patients enrolled in clinical trials according to their age. Secondary objective was to identify variables associated with enrollment in older ones.5552 women were aged ≥ 70 (median 74yo; IQR 72-77). 14,611 were less than 70. Of the older ones, 239 (4%) were enrolled in a clinical trial during first line of treatment, compared with 1529 (10.5%) for younger ones. Multivariable analysis of variables predicting for enrollment during first line of treatment in older patients were younger age (OR 0.50 [95%CI 0.33-0.76] for the 80-85yo class; OR 0.17 [95%CI 0.06-0.39] for the 85yo and more class), good ECOG Performance Status (PS 0-1) (OR 0.15 [95%CI 0.08-0.27] for the PS 2-4 class), HER2 + disease (OR 1.78 [95%CI 1.27-2.48]), type of treatment (chemotherapy/targeted therapy/immunotherapy OR 5.01 [95%CI 3.13-8.18]), and period (OR 1.65 [95%CI 1.22-2.26] for 2012-2016, compared to 2008-2011).In this large database, few older MBC patients were enrolled in a trial compared with younger ones.

Published
2021

17. Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index

Author

Christos Adamopoulos, Tamer Ahmed, Peter M. Ung, Min Xiao, Stuart Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, and Poulikos I. Poulikakos

Subjects
Cancer Research, Oncology
Abstract

BRAF kinase, a critical component of the RAS/MAPK signaling pathway, requires dimerization for its catalytic activity, whereas the oncoprotein BRAF(V600E) can be catalytically active as a monomer. Current clinical BRAF inhibitors selectively bind and inhibit monomeric over dimeric BRAF (i.e. “BRAF monomer-selective”) providing a high therapeutic index and are now standard practice in combination with MEK inhibitors in the treatment of patients harboring BRAF(V600E) tumors. However adaptive resistance due to RAF dimerization limits their effectiveness. Recently, RAF inhibitors that equipotently inhibit both monomeric and dimeric BRAF have been developed, but they are predicted to have lower therapeutic index due to inhibition of dimeric wild-type BRAF in normal tissues. We identified and characterized a novel class of BRAF inhibitors that preferentially bind and inhibit dimeric over monomeric BRAF(V600E) (i.e. “BRAF dimer-selective inhibitors”). Biochemical analysis using BRAF dimer-selective inhibitors revealed that the two forms of dimeric and monomeric BRAF(V600E) differ in their conformation in their active site and their strength of interaction with MEK. Further, to maximally inhibit BRAF(V600E) signaling in tumors while retaining a broad therapeutic index, we assessed the triple combination of BRAF monomer- plus BRAF dimer selective inhibitor plus a MEK inhibitor that disrupts the BRAF-MEK complex. The triple combination potently suppressed tumor growth in multiple colorectal and melanoma BRAF(V600E) cell line- and in vivo models that were resistant to the current clinical BRAF and MEK inhibitor combination. Strikingly, while the double combination treatment with the BRAF dimer-selective inhibitor and MEK inhibitor was associated with a significant gradual weight loss in vivo, the triple combination showed no weight loss or other apparent toxicities, indicating a higher Therapeutic Index. Finally, off-label use of the triple combination in patients with advanced BRAF(V600E) cancers that progressed on standard therapies achieved durable tumor control with minimal toxicities. Thus, a rationally designed combinatorial approach of conformation-selective BRAF and MEK inhibitors may be a highly effective and well tolerated therapeutic strategy for patients with BRAF(V600E) tumors. Overall, our work supports the notion that for most tumors a “3-drug” combinatorial strategy will potentially be most effective: one drug targeting MAPK signaling directly, such as a MEK inhibitor (“pathway” inhibitor), one drug targeting mutated BRAF or RAS selectively in the tumor (“therapeutic index” inhibitor, e.g. BRAF monomer-selective inhibitor, RAS(G12C) inhibitors, etc) and one drug targeting components of the feedback loop that is responsible for adaptive resistance (“feedback” inhibitor, e.g. BRAF dimer-selective inhibitors, SHP2 or SOS inhibitors, etc). Our data contribute to the development of a roadmap for the treatment of MAPK-driven tumors using drug combinations tailored to the specific driver oncoprotein. Citation Format: Christos Adamopoulos, Tamer Ahmed, Peter M. Ung, Min Xiao, Stuart Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Poulikos I. Poulikakos. BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB083.

Published
2022

18. Borosilicate glass

Author

A A Z Ahmad, Nazeri, S F Abdul, Sani, N M, Ung, K S, Almugren, F H, Alkallas, and D A, Bradley

Subjects
Boron Compounds, Silicates, Brachytherapy, Water, Radiotherapy Dosage, Thermoluminescent Dosimetry, Glass, Cobalt Radioisotopes
Abstract

Brachytherapy is commonly used in treatment of cervical, prostate, breast and skin cancers, also for oral cancers, typically via the application of sealed radioactive sources that are inserted within or alongside the area to be treated. A particular aim of the various brachytherapy techniques is to accurately transfer to the targeted tumour the largest possible dose, at the same time minimizing dose to the surrounding normal tissue, including organs at risk. The dose fall-off with distance from the sources is steep, the dose gradient representing a prime factor in determining the dose distribution, also representing a challenge to the conduct of measurements around sources. Amorphous borosilicate glass (B

Published
2021

19. PO-1099 To plan and deliver adjuvant breast radiotherapy over 1 week: 1-week breast workflow implementation

Author

N. Fournier-Bidoz, Guillaume Louvel, Sofia Rivera, Patrick Ezra, E. Roberti, I. Yessoufou, M. Ung, E. Folino, C. Milewski, G. Auzac, F. Villaret, N. Paragios, Eric Deutsch, K. Berthelot, and M. Cheve

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, medicine.medical_treatment, Breast radiotherapy, Hematology, Follow up evaluation, Workflow, Oncology, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, business, Radiation treatment planning, Adjuvant, Quality assurance, Radiation oncologist
Abstract

Purpose or Objective To limit hospital visits and transportation of the patients with early breast cancer (BC) especially during the covid-19 pandemic, we aimed to implement a workflow of treatment to prepare and deliver adjuvant breast radiotherapy (RT) within 1 week. Materials and Methods Based on the Fast Forward RT schedule of 5 fractions of 5.2 Gy over 5 days for adjuvant BC, we designed a workflow to perform BC RT over 1 week from the first RT consultation to the end of treatment (figure 1). Patients were seen in consultation on Monday morning. The planning CT was carried out immediately after the consultation. A deep inspiration breath-hold technique was systematically offered to all patients. Automatic delineation using an artificial Intelligence (AI) based model with ART-PlanTM software was first corrected by a junior radiation oncologist (RO) then, independently by a senior RO. As 3D conformal RT failed to achieve dose constraints of the fast forward trial in many cases (due to breast hotspots), we developed a restricted IMRT (rIMRT) technique based on 2 tangential beams (internal and external) using inverse planning restricted optimization parameters to improve the dose homogeneity. Treatment planning was semi-automated by scripting the creation and optimization steps of rIMRT plans. After validation of the reliability of rIMRT treatment delivery by patient-specific quality assurance (PSQA) with gamma index evaluation on 20 patients, we decided to abandon systematic PSQAs. In-vivo dosimetry was validated by end-to-end controls and performed for each patient during the first fraction on Monday afternoon. Daily repositioning was controlled by portal images of the largest segment of each beam. Structured baseline, end of treatment and follow up evaluation forms were used to prospectively collect toxicities and oncological outcomes at each consultation. Patient agreement for data collection and analysis was prospectively obtained. $Φg Results From February 2021 to March 2021, the 1-week breast procedure was proposed to up to 3 patients/week, >65 years, in complete resection after conservative surgery, with pT1-T3 N0 BC, without tumor bed boost or regional lymph nodes irradiation. Six out of seven patients (85.7%) accepted the 1-week breast procedure. All procedures were successfully conducted over 5 days with complete patient and RT team satisfaction. A followup of acute toxicities by online consultation on day 10, structured evaluation forms and management decision trees has been implemented for these patients. No grade >2 acute toxicities (CTACE V4.0) have been reported so far. Conclusion The successful implementation of this comprehensive 1-week breast workflow with AI based delineation and semi-automated rIMRT without PSQA demonstrates the practical feasibility of the whole procedure over 5 days reducing drastically the coming-and-going to the hospital and the overall RT management time per patient. Our work opens the way for further development of comprehensive compact workflows in various settings.

Published
2021

20. Correlation analysis of CT-based rectal planning dosimetric parameters with in vivo dosimetry of MOSkin and PTW 9112 detectors in Co-60 source HDR intracavitary cervix brachytherapy

Author

Z, Jamalludin, R A, Malik, and N M, Ung

Subjects
Brachytherapy, Humans, Female, Radiotherapy Dosage, Cervix Uteri, Cobalt Radioisotopes, In Vivo Dosimetry, Tomography, X-Ray Computed, Retrospective Studies
Abstract

Intracavitary cervical brachytherapy delivers high doses of radiation to the target tissue and a portion of these doses will also hit the rectal organs due to their close proximity. Rectal dose can be evaluated from dosimetric parameters in the treatment planning system (TPS) and in vivo (IV) dose measurement. This study analyzed the correlation between IV rectal dose with selected volume and point dose parameters from TPS. A total of 48 insertions were performed and IV dose was measured using the commercial PTW 9112 semiconductor diode probe. In 18 of 48 insertions, a single MOSkin detector was attached on the probe surface at 50 mm from the tip. Four rectal dosimetric parameters were retrospectively collected from TPS; (a) PTW 9112 diode maximum reported dose (RP

Published
2020

21. Two-pion femtoscopic correlations in Be+Be collisions at $$\sqrt{s_{\text {NN}}} = 16.84$$ s NN = 16.84 GeV measured by the NA61/SHINE at CERN

Author

H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I.-C. Arsene, M. Bajda, Y. Balkova, M. Baszczyk, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, A. Dmitriev, P. von Doetinchem, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, K. Kadija, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, H. Kitagawa, R. Kolesnikov, D. Kolev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, A. Morawiec, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, K. Sakashita, K. Schmidt, A. Yu. Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, Ł. Świderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, R. Zwaska, and NA61/SHINE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract This paper reports measurements of two-pion femtoscopic correlations in Be+Be collisions at a beam momentum of 150 $$A\,\hbox {GeV}\!/\!c$$ A GeV / c (energy available in the center-of-mass system for nucleon pair $$\sqrt{s_{\text {NN}}} = 16.84$$ s NN = 16.84 GeV) by the NA61/SHINE experiment at the CERN SPS accelerator. The obtained momentum space correlation functions can be well described by a Lévy distributed source model. The transverse mass dependence of the Lévy source parameters is presented, and their possible theoretical interpretations are discussed. The results show that the Lévy exponent $$\alpha $$ α is approximately constant as a function of $$m_{\text {T}}$$ m T , and far from both the Gaussian case of $$\alpha = 2$$ α = 2 or the conjectured value at the critical endpoint, $$\alpha = 0.5$$ α = 0.5 . The radius scale parameter R shows a slight decrease in $$m_{\text {T}}$$ m T , which can be explained as a signature of transverse flow. Finally, an approximately constant trend of the intercept parameter $$\lambda $$ λ as a function of $$m_{\text {T}}$$ m T was observed, similar to previous NA44 S + Pb results (obtained with a Gaussian approximation, but unlike RHIC results).

Published
2023
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22. [Dosimetric impact of hydrogel spacer use for stereotactic body radiotherapy of localised prostate cancer]

Author

M, Ung, A, Bossi, L, Abbassi, J, Vautier, V, Anthonipillai, M, Chevé, and P, Blanchard

Subjects
Aged, 80 and over, Male, Organs at Risk, Urinary Bladder, Rectum, Prostatic Neoplasms, Hydrogels, Radiotherapy Dosage, Middle Aged, Radiosurgery, Statistics, Nonparametric, Feasibility Studies, Humans, Radiation Injuries, Aged, Anesthesia, Local, Retrospective Studies
Abstract

Stereotactic body radiotherapy (SBRT) of prostate cancer is associated with rectal toxicities, which can be reduced by using a hydrogel spacer. The object of this retrospective study was to show the feasibility of spacer placement under local anesthesia and utility of hydrogel spacer to reduce the dose to the rectal wall.We collected data from all patients with localised prostate cancer treated with SBRT (40Gy in 5 fractions) between 2018 and 2020. A hydrogel spacer (SpaceOAR®) was placed depending on the availability of the product. We collected dosimetric data for target volumes and organs at risk. We calculated mean values, which were compared using non-parametric tests.Among 35 patients, mean age was 75 years. Seventeen had a spacer placed, with a mean space created of 10mm. No complication was reported during the intervention. High doses to the rectal wall were significantly lower in spacer group (V38: 0.39 cmSpacer procedure under local anesthesia was well tolerated. Hydrogel spacer allowed to reduce doses to the rectum while improving PTV coverage.

Published
2020

23. Evaluation of rectal dose discrepancies between planned and in vivo dosimetry using MOSkin detector and PTW 9112 semiconductor probe during

Author

Z, Jamalludin, W L, Jong, R A, Malik, A B, Rosenfeld, and N M, Ung

Subjects
Semiconductors, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, Brachytherapy, Rectum, Humans, Uterine Cervical Neoplasms, Female, Radiotherapy Dosage, Cervix Uteri, Cobalt Radioisotopes, Radiometry, Tomography, X-Ray Computed
Abstract

Dose to the rectum during brachytherapy treatment may differ from an approved treatment plan which can be quantified with in vivo dosimetry (IVD). This study compares the planned with in vivo doses measured with MOSkin and PTW 9112 rectal probe in patients undergoing CT based HDR cervical brachytherapy with Co-60 source.Dose measurement of a standard pear-shaped plan carried out in phantom to verify the MOSkin dose measurement accuracy. With MOSkin attached to the third diode, RP3 of the PTW 9112, both detectors were inserted into patients' rectum. The RP3 and MOSkin measured doses in 18 sessions as well as the maximum measured doses from PTW 9112, RPPercentage dose differences ΔD (%) in phantom study for two MOSkin found to be 2.22 ± 0.07% and 2.5 ± 0.07%. IVD of 18 sessions resulted in ΔD(%) of -16.3% to 14.9% with MOSkin and ΔD(%) of -35.7% to -2.1% with RP3. In 48 sessions, RPThe delivered doses proven to deviate from planned doses due to unavoidable shift between imaging and treatment as measured with MOSkin and PTW 9112 detectors. The integration of MOSkin on commercial PTW 9112 surface found to be feasible for rectal dose IVD during cervical HDR ICBT.

Published
2019

24. Beam spin asymmetry measurements of deeply virtual π0 production with CLAS12

Author

A. Kim, S. Diehl, K. Joo, V. Kubarovsky, P. Achenbach, Z. Akbar, J.S. Alvarado, Whitney R. Armstrong, H. Atac, H. Avakian, C. Ayerbe Gayoso, L. Barion, M. Battaglieri, I. Bedlinskiy, B. Benkel, A. Bianconi, A.S. Biselli, M. Bondi, F. Bossù, S. Boiarinov, K.T. Brinkmann, W.J. Briscoe, W.K. Brooks, S. Bueltmann, V.D. Burkert, R. Capobianco, D.S. Carman, J.C. Carvajal, A. Celentano, G. Charles, P. Chatagnon, V. Chesnokov, T. Chetry, G. Ciullo, B. Clary, G. Clash, P.L. Cole, M. Contalbrigo, G. Costantini, V. Crede, A. D'Angelo, N. Dashyan, R. De Vita, M. Defurne, A. Deur, C. Dilks, C. Djalali, R. Dupre, H. Egiyan, M. Ehrhart, A. El Alaoui, L. El Fassi, S. Fegan, A. Filippi, C. Fogler, G. Gavalian, G.P. Gilfoyle, G. Gosta, F.X. Girod, D.I. Glazier, A.A. Golubenko, R.W. Gothe, L. Guo, K. Hafidi, H. Hakobyan, M. Hattawy, F. Hauenstein, T.B. Hayward, D. Heddle, A. Hobart, M. Holtrop, Yu-Chun Hung, Y. Ilieva, D.G. Ireland, E. Isupov, H.S. Jo, R. Johnston, S. Joosten, M. Khachatryan, A. Khanal, W. Kim, V. Klimenko, A. Kripko, S.E. Kuhn, L. Lanza, M. Leali, M.L. Kabir, S. Lee, P. Lenisa, X. Li, I. .J.D. MacGregor, D. Marchand, V. Mascagna, B. McKinnon, D. Matamoros, S. Migliorati, T. Mineeva, M. Mirazita, V. Mokeev, P. Moran, C. Munoz Camacho, P. Naidoo, K. Neupane, D. Nguyen, S. Niccolai, G. Niculescu, M. Osipenko, M. Ouillon, P. Pandey, M. Paolone, L.L. Pappalardo, R. Paremuzyan, E. Pasyuk, S.J. Paul, W. Phelps, N. Pilleux, M. Pokhrel, J. Poudel, J.W. Price, Y. Prok, A. Radic, N. Ramasubramanian, Trevor Reed, J. Richards, M. Ripani, J. Ritman, P. Rossi, F. Sabatié, C. Salgado, S. Schadmand, A. Schmidt, Y.G. Sharabian, E.V. Shirokov, U. Shrestha, D. Sokhan, N. Sparveris, M. Spreafico, S. Stepanyan, I.I. Strakovsky, S. Strauch, J. Tan, N. Trotta, R. Tyson, M. Ungaro, S. Vallarino, L. Venturelli, H. Voskanyan, E. Voutier, D.P. Watts, X. Wei, R. Wishart, M.H. Wood, M. Yurov, N. Zachariou, J. Zhang, V. Ziegler, and M. Zurek

Subjects
Physics, QC1-999
Abstract

The new experimental measurements of beam spin asymmetry were performed for the deeply virtual exclusive π0 production in a wide kinematic region with the photon virtualities Q2 up to 6.6 GeV2 and the Bjorken scaling variable xB in the valence regime. The data were collected by the CEBAF Large Acceptance Spectrometer (CLAS12) at Jefferson Lab with longitudinally polarized 10.6 GeV electrons scattered on an unpolarized liquid-hydrogen target. Sizable asymmetry values indicate a substantial contribution from transverse virtual photon amplitudes to the polarized structure functions. The interpretation of these measurements in terms of the Generalized Parton Distributions (GPDs) demonstrates their sensitivity to the chiral-odd GPD E¯T, which contains information on quark transverse spin densities in unpolarized and polarized nucleons and provides access to the nucleon's transverse anomalous magnetic moment. Additionally, the data were compared to a theoretical model based on a Regge formalism that was extended to the high photon virtualities.

Published
2024
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25. Search for the critical point of strongly-interacting matter in 40Ar + 45Sc collisions at 150A Ge V /c using scaled factorial moments of protons

Author

H. Adhikary, P. Adrich, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I.-C. Arsene, M. Bajda, Y. Balkova, M. Baszczyk, D. Battaglia, A. Bazgir, S. Bhosale, M. Bielewicz, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, W. Bryliński, J. Brzychczyk, M. Buryakov, A. F. Camino, P. Christakoglou, M. Ćirković, M. Csanád, J. Cybowska, T. Czopowicz, C. Dalmazzone, N. Davis, F. Diakonos, A. Dmitriev, P. von Doetinchem, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, K. Kadija, A. Kapoyannis, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, H. Kitagawa, R. Kolesnikov, D. Kolev, Y. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuchowicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. Merzlaya, Ł. Mik, A. Morawiec, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, S. Nishimori, V. Ozvenchuk, A. D. Panagiotou, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Pórfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, R. Renfordt, L. Ren, V. Z. Reyna Ortiz, D. Röhrich, E. Rondio, M. Roth, Ł. Rozpłochowski, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, K. Sakashita, K. Schmidt, A. Yu. Seryakov, P. Seyboth, U. A. Shah, Y. Shiraishi, A. Shukla, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, L. Swiderski, J. Szewiński, R. Szukiewicz, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, M. Urbaniak, F. F. Valiev, M. Vassiliou, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The critical point of dense, strongly interacting matter is searched for at the CERN SPS in 40Ar + 45Sc collisions at 150A Ge V /c. The dependence of second-order scaled factorial moments of proton multiplicity distribution on the number of subdivisions of transverse momentum space is measured. The intermittency analysis is performed using both transverse momentum and cumulative transverse momentum. For the first time, statistically independent data sets are used for each subdivision number. The obtained results do not indicate any statistically significant intermittency pattern. An upper limit on the fraction of correlated proton pairs and the power of the correlation function is obtained based on a comparison with the Power-law Model developed for this purpose.

Published
2023
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26. Improving Radiotherapy Workflow Through Implementation of Delineation Guidelines & AI-Based Annotation

Author

N. Bonnet, C. Robert, Nikos Paragios, L.G. Assia, M. Ung, E. Ullman, T. Sarrade, Eric Deutsch, A. Lombard, G. Auzac, Elaine Johanna Limkin, A. Carré, Claire Petit, Sofia Rivera, C. Huynh, and A. Rouyar-Nicolas

Subjects
Radiation therapy, Cancer Research, Annotation, Radiation, Workflow, Oncology, business.industry, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, business, Software engineering
Published
2020

27. Impact dosimétrique et clinique de la pose d’un espaceur rectal dans le traitement de cancer de prostate localisé par irradiation en conditions stéréotaxiques

Author

V. Anthonipillai, L.M. Abbassi, Alberto Bossi, Pierre Blanchard, M. Cheve, J. Vautier, and M. Ung

Subjects
Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, business
Abstract

Introduction et but de l’etude La radiotherapie stereotaxique du cancer de prostate localise est pourvoyeuse de toxicite rectale, qui peut etre reduite en utilisant un espaceur rectal. L’objectif de cette etude retrospective etait de demontrer la faisabilite d’une implantation sous anesthesie locale et l’utilite d’un espaceur dans la reduction de la dose dans la paroi rectale. Materiel et methodes Nous avons recueilli les donnees de l’ensemble des patients atteints d’un adenocarcinome de prostate localise traite par irradiation stereotaxique de 40 Gy en cinq fractions entre 2018 et 2020. Un espaceur (SpaceOAR®) a ete mis en place en fonction de la disponibilite du dispositif. Nous avons releve des indicateurs dosimetriques concernant le volume cible et les organes a risque. Les valeurs continues ont ete representees par leurs moyennes et comparees avec un test de Mann–Whitney. Resultats et analyse statistique Parmi les 35 patients, 17 ont beneficie de la pose d’un espaceur rectal, sans complication lors de l’implantation, permettant un espacement moyen de 10 mm. Les fortes doses dans la paroi rectale etaient significativement plus basses dans le groupe beneficiant de l’espaceur (volume recevant 38 Gy : 0,39 cm3 contre 0,72 cm3 ; p = 0,02). Il y avait une tendance a une meilleure couverture du volume cible previsionnel dans le groupe beneficiant de l’espaceur (p = 0,07). Les doses recues dans la paroi vesicale etaient similaires entre les deux groupes. Conclusion L’implantation sous anesthesie locale d’un espaceur rectal est faisable, et s’accompagne d’une diminution de la dose dans le rectum. L’espaceur semble permettre une meilleure couverture du volume cible previsionnel.

Published
2020

28. Dosimetric impact of an AI-based delineation software satisfying international guidelines in breast cancer radiotherapy

Author

E. Ullmann, A. Carré, Claire Petit, Elaine Johanna Limkin, Eric Deutsch, T. Sarrade, C. Robert, Angela Rouyar, A. Lombard, N. Paragios, M. Ung, C. Martineau-Huynh, A. Lamrani-Ghaouti, N. Bonnet, Sofia Rivera, and G. Auzac

Subjects
Cancer Research, medicine.medical_specialty, Software, Oncology, business.industry, medicine, Medical physics, Breast cancer radiotherapy, business
Published
2020

29. Asian American college women’s in-the-moment responses to a dating violence situation

Author

Hong V. Nguyen, Rebecca L. Schacht, Michelle A. Jackson, Cindy M. Ung, David W. Pantalone, and William H. George

Subjects
Moment (mathematics), Asian americans, 05 social sciences, Domestic violence, 050109 social psychology, 0501 psychology and cognitive sciences, Gender studies, Dating violence, Psychology, General Psychology, Human Females, 050104 developmental & child psychology
Published
2016

30. Erratum to: Measurements of $$\pi ^\pm $$ π ± , $$K^\pm $$ K ± , p and $$\bar{p}$$ p ¯ spectra in $$^7$$ 7 Be+ $$^9$$ 9 Be collisions at beam momenta from 19A to 150A GeV/c with the NA61/SHINE spectrometer at the CERN SPS

Author

A. Acharya, H. Adhikary, A. Aduszkiewicz, K. K. Allison, E. V. Andronov, T. Antićić, V. Babkin, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, M. Koziel, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, S. Mrówczyński, Y. Nagai, M. Naskręt, V. Ozvenchuk, V. Paolone, O. Petukhov, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, R. Ulrich, M. Unger, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, Z. Włodarczyk, K. Wojcik, O. Wyszyński, E. D. Zimmerman, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2023
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31. The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

Author

Cody J. Aros, Dinesh S. Rao, Giuseppe Basso, Jasmine Gajeton, Tiffany M. Tran, David Casero, Ella V. Waters, Martina Pigazzi, Nolan M. Ung, Norma I. Rodriguez-Malave, Jorge R. Contreras, Matteo Zampini, Michael O. Alberti, Jaime Anguiano, Jayanth Kumar Palanichamy, and Thilini Fernando

Subjects
0301 basic medicine, Myeloid, Cancer Research, Translocation, Genetic, chemistry.chemical_compound, Mice, 0302 clinical medicine, hemic and lymphatic diseases, Gene expression, Promoter Regions, Genetic, Child, YY1 Transcription Factor, Cancer, Pediatric, Acute leukemia, Gene knockdown, Tumor, Leukemia, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, 3. Good health, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Acute, B-all, CASC15, ETV6-RUNX1, Non-coding RNA, SOX4, Molecular Medicine, Oncology, RUNX1, 030220 oncology & carcinogenesis, Core Binding Factor Alpha 2 Subunit, RNA, Long Noncoding, Long Noncoding, Biotechnology, Pediatric Research Initiative, Pediatric Cancer, Childhood Leukemia, Oncology and Carcinogenesis, Translocation, Biology, Acute, lcsh:RC254-282, Cell Line, SOXC Transcription Factors, Promoter Regions, 03 medical and health sciences, Rare Diseases, Genetic, Cell Line, Tumor, medicine, Genetics, Animals, Humans, Oncology & Carcinogenesis, Cell Proliferation, Neoplastic, YY1, Research, Gene Expression Profiling, medicine.disease, Gene expression profiling, 030104 developmental biology, Orphan Drug, chemistry, Gene Expression Regulation, Cancer research, RNA
Abstract

Background Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia. Results CASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis. Enforced expression of CASC15 led to a myeloid bias in development, and overall, decreased engraftment and colony formation. At the cellular level, CASC15 regulated cellular survival, proliferation, and the expression of its chromosomally adjacent gene, SOX4. Differentially regulated genes following CASC15 knockdown were enriched for predicted transcriptional targets of the Yin and Yang-1 (YY1) transcription factor. Interestingly, we found that CASC15 enhances YY1-mediated regulation of the SOX4 promoter. Conclusions Our findings represent the first characterization of this CASC15 in RUNX1-translocated leukemia, and point towards a mechanistic basis for its action. Electronic supplementary material The online version of this article (doi:10.1186/s12943-017-0692-x) contains supplementary material, which is available to authorized users.

Published
2017

32. Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a

Author

Dinesh S. Rao, Matteo Pellegrini, Nolan M. Ung, Thilini Fernando, Jorge R. Contreras, Michael O. Alberti, Jennifer K. King, May Paing, and Kelvin Xi Zhang

Subjects
0301 basic medicine, Cellular differentiation, 1.1 Normal biological development and functioning, Immunology, Notch signaling pathway, Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Underpinning research, microRNA, Genetics, Immunology and Allergy, Original Research, Regulation of gene expression, Marginal zone B cell differentiation, B-cell development, Human Genome, Marginal zone, Stem Cell Research, Phenotype, notch signaling, 030104 developmental biology, Medical Microbiology, 030220 oncology & carcinogenesis, marginal zone B-cells, gene regulation, Biotechnology
Abstract

B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the elaboration of distinct gene expression programs for development. Given their role in gene regulation, it is not surprising that microRNAs are important factors in B-cell development. Recent work demonstrated that deficiency of the NFκB feedback regulator, miR-146a, led to a range of hematopoietic phenotypes, but B-cell phenotypes have not been extensively characterized. Here, we found that miR-146a-deficient mice demonstrate a reduction in MZ B-cells, likely from a developmental block. Utilizing high-throughput sequencing and comparative analysis of developmental stage-specific transcriptomes, we determined that MZ cell differentiation was impaired due to decreases in Notch2 signaling. Our studies reveal miR-146a-dependent B-cell phenotypes and highlight the complex role of miR-146a in the hematopoietic system.

Published
2017
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33. A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles

Author

L. Paul Sands, Elise A. Kikis, Amy L. Lee, and Hailey M. Ung

Subjects
0301 basic medicine, Huntingtin, Nematoda, lcsh:Medicine, Muscle Proteins, Toxicology, Pathology and Laboratory Medicine, Biochemistry, Animals, Genetically Modified, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Myocyte, lcsh:Science, Caenorhabditis elegans, Neurons, Huntingtin Protein, Microscopy, Multidisciplinary, biology, Muscles, Neurodegeneration, Light Microscopy, Anatomy, Animal Models, Polyglutamine tract, Cell biology, Huntington Disease, Experimental Organism Systems, Cellular Types, Research Article, congenital, hereditary, and neonatal diseases and abnormalities, Yellow Fluorescent Protein, Fluorescence Recovery after Photobleaching, Longevity, Muscle Tissue, Context (language use), Mouse Models, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, mental disorders, medicine, Animals, Humans, Muscle Cells, Toxicity, lcsh:R, Organisms, Biology and Life Sciences, Proteins, Cell Biology, medicine.disease, biology.organism_classification, Invertebrates, Peptide Fragments, Disease Models, Animal, Luminescent Proteins, 030104 developmental biology, Biological Tissue, Proteotoxicity, Cellular Neuroscience, Caenorhabditis, lcsh:Q, Peptides, 030217 neurology & neurosurgery, Neuroscience
Abstract

Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington's Disease (HD) that is caused by a polyglutamine expansion in the human huntingtin protein (htt). The polyglutamine expansion destabilizes htt leading to protein misfolding, which in turn triggers neurodegeneration and the disruption of energy metabolism in muscle cells. However, the molecular mechanisms that underlie htt proteotoxicity have been somewhat elusive, and the muscle phenotypes have not been well studied. To generate tools to elucidate the basis for muscle dysfunction, we engineered Caenorhabditis elegans to express a disease-associated 513 amino acid fragment of human htt in body wall muscle cells. We show that this htt fragment aggregates in C. elegans in a polyglutamine length-dependent manner and is toxic. Toxicity manifests as motor impairment and a shortened lifespan. Compared to previous models, the data suggest that the protein context in which a polyglutamine tract is embedded alters aggregation propensity and toxicity, likely by affecting interactions with the muscle cell environment.

Published
2016

34. Auxetic properties of some intermetallic compounds

Author

M. Raransky, A. Oliinych-Lysiuk, R. Tashchuk, A. Tashchuk, A. Struk, and M. Unguryan

Subjects
auxetic, young's moduls, poisson’s ratios, anomalous deformations, anisotropy, elastic properties, Physics, QC1-999
Abstract

With the application of a linear theory of elasticity of anisotropic crystals and the use of experimental values of elastic moduli Сij and compliances Sij given in the Landolt-Börstein tables, characteristic surfaces of Young's moduli, angular distributions of Poisson's ratios μ(φ, Θ, ψ) and indicating auxeticity surfaces of single crystals of intermetallic compounds Ag-Au, Cu-Ni, Cu-Au, and Cu-Zn were for the first time constructed. The extremely high sensitivity of the component of the extreme values of Young's moduli E to anomalous deformations during phase transformations of the order-disorder type was established. Anomalies of the concentration dependences of the auxetic parameters μmin(X), μmax(X) and the auxeticity degree Sa(X) near the points of phase transformation of the second order type were revealed.

Published
2022
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35. Faisabilité d’une diminution du rythme des consultations de surveillance pendant une irradiation mammaire

Author

F. Bintein, M. Minsat, J. Otz, A. De Oliveira, E. Musat, M. Ung, J. Lavaud, H. Albert-Dufrois, M.H. Muresan, A. Clément-Zhao, and B. De La Lande

Subjects
Oncology, Radiology, Nuclear Medicine and imaging
Abstract

Objectif de l’etude En cours d’irradiation mammaire, une surveillance hebdomadaire est habituelle. Celle-ci est consommatrice de temps et de moyens medicotechniques, alors que la toxicite attendue est moderee. L’objectif de cette etude prospective monocentrique est d’evaluer la faisabilite d’une diminution du rythme des consultations de surveillance durant une irradiation mammaire. Materiel et methode A partir du 1er decembre 2017, le rythme de consultation des patientes debutant une irradiation mammaire normofractionnee a ete espacee aux deuxieme et cinquieme semaines de traitement. Si besoin, elles pouvaient demander une consultation non programmee avec le medecin d’astreinte. Le critere d’evaluation principal etait le nombre de patients ayant eu au moins une consultation non programmee. Les criteres d’evaluation secondaires etaient le motif principal de la consultation, le nombre de radiodermites de grade > 2 et la recherche de facteur predictif. Resultats Entre le 1er decembre 2017 et le 30 janvier 2018, 127 patientes ont recu une irradiation mammaire dans notre centre. Trente-trois (26 %) ont eu au moins une consultation non programmee durant leur traitement et huit (6,3 %) en ont eu plus d’une, soit au total 43 consultations non programmees. Une irradiation ganglionnaire etait associee a l’irradiation mammaire ou parietale dans 20,9 % des cas. Le motif principal de la consultation etait majoritairement un probleme cutane (83,7 %) avec une radiodermite de grade 3 dans 16,3 % des cas. La dose moyenne recue etait 43,8 Gy [2,2–65 Gy]. Plus de la moitie des patientes (55,9 %) avait une taille de soutien-gorge superieure a un bonnet B. Conclusion En cours d’irradiation mammaire, une consultation de surveillance aux deuxieme et cinquieme semaines de traitements parait realisable mais non optimale. Plus d’un quart des patientes a eu recours a une consultation non programmee, principalement a la quatrieme semaine et pour toxicite cutanee. Un rythme de consultation toutes les deux semaines de traitement semble plus approprie, avec maintien des consultations non programmees a la demande.

Published
2018

37. A multidimensional study of the structure function ratio σLT′/σ0 from hard exclusive π+ electro-production off protons in the GPD regime

Author

S. Diehl, A. Kim, K. Joo, P. Achenbach, Z. Akbar, M.J. Amaryan, H. Atac, H. Avagyan, C. Ayerbe Gayoso, L. Baashen, L. Barion, M. Bashkanov, M. Battaglieri, I. Bedlinskiy, B. Benkel, F. Benmokhtar, A. Bianconi, A.S. Biselli, M. Bondi, W.A. Booth, F. Bossù, S. Boiarinov, K.-Th. Brinkmann, W.J. Briscoe, S. Bueltmann, D. Bulumulla, V.D. Burkert, D.S. Carman, A. Celentano, P. Chatagnon, V. Chesnokov, T. Chetry, G. Ciullo, G. Clash, P.L. Cole, M. Contalbrigo, G. Costantini, A. D'Angelo, N. Dashyan, R. De Vita, M. Defurne, A. Deur, C. Djalali, R. Dupre, H. Egiyan, M. Ehrhart, A. El Alaoui, L. El Fassi, L. Elouadrhiri, S. Fegan, A. Filippi, G. Gavalian, Y. Ghandilyan, G.P. Gilfoyle, D.I. Glazier, A.A. Golubenko, G. Gosta, R.W. Gothe, Y. Gotra, K.A. Griffioen, M. Guidal, K. Hafidi, H. Hakobyan, M. Hattawy, T.B. Hayward, D. Heddle, A. Hobart, M. Holtrop, Y. Ilieva, D.G. Ireland, E.L. Isupov, H.S. Jo, M. Khachatryan, A. Khanal, W. Kim, A. Kripko, V. Kubarovsky, V. Lagerquist, J.-M. Laget, L. Lanza, M. Leali, S. Lee, P. Lenisa, X. Li, K. Livingston, I. .J .D. MacGregor, D. Marchand, V. Mascagna, B. McKinnon, Z.E. Meziani, S. Migliorati, T. Mineeva, M. Mirazita, V. Mokeev, E. Molina, R.A. Montgomery, C. Munoz Camacho, P. Nadel-Turonski, P. Naidoo, K. Neupane, S. Niccolai, M. Nicol, G. Niculescu, M. Osipenko, M. Ouillon, P. Pandey, M. Paolone, L.L. Pappalardo, R. Paremuzyan, E. Pasyuk, S.J. Paul, W. Phelps, N. Pilleux, M. Pokhrel, J. Poudel, J.W. Price, Y. Prok, T. Reed, J. Richards, M. Ripani, J. Ritman, P. Rossi, F. Sabatié, C. Salgado, S. Schadmand, A. Schmidt, Y. Sharabian, E.V. Shirokov, U. Shrestha, P. Simmerling, D. Sokhan, N. Sparveris, M. Spreafico, S. Stepanyan, I.I. Strakovsky, S. Strauch, J.A. Tan, N. Trotta, M. Turisini, R. Tyson, M. Ungaro, S. Vallarino, L. Venturelli, H. Voskanyan, E. Voutier, D.P. Watts, X. Wei, R. Williams, R. Wishart, M.H. Wood, N. Zachariou, J. Zhang, Z.W. Zhao, and M. Zurek

Subjects
Exclusive single pion, Eletroproduction, GPD, CLAS12, Physics, QC1-999
Abstract

A multidimensional extraction of the structure function ratio σLT′/σ0 from the hard exclusive e→p→e′nπ+ reaction above the resonance region has been performed. The study was done based on beam-spin asymmetry measurements using a 10.6 GeV incident electron beam on a liquid-hydrogen target and the CLAS12 spectrometer at Jefferson Lab. The measurements focus on the very forward regime (t/Q2 ≪ 1) with a wide kinematic range of xB in the valence regime (0.17 < xB < 0.55), and virtualities Q2 ranging from 1.5 GeV2 up to 6 GeV2. The results and their comparison to theoretical models based on Generalized Parton Distributions demonstrate the sensitivity to chiral-odd GPDs and the directly related tensor charge of the nucleon. In addition, the data is compared to an extension of a Regge formalism at high photon virtualities. It was found that the Regge model provides a better description at low Q2, while the GPD model is more appropriate at high Q2.

Published
2023
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38. $$K^{*}(892)^0$$ K ∗ ( 892 ) 0 meson production in inelastic p+p interactions at 40 and 80 $$\text{ GeV }\!/\!c$$ GeV / c beam momenta measured by NA61/SHINE at the CERN SPS

Author

A. Acharya, H. Adhikary, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, I. -C. Arsene, M. Baszczyk, D. Battagia, S. Bhosale, A. Blondel, M. Bogomilov, Y. Bondar, N. Bostan, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, M. Friend, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, A. Izvestnyy, S. R. Johnson, K. Kadija, N. Kargin, N. Karpushkin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, R. Kolesnikov, D. Kolev, A. Korzenev, J. Koshio, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, A. László, M. Lewicki, K. Łojek, G. Lykasov, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, A. Makhnev, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H. -J. Mathes, T. Matulewicz, V. Matveev, A. Matyja, G. L. Melkumov, A. Merzlaya, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, Y. Nagai, T. Nakadaira, M. Naskręt, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, K. Sakashita, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, T. S. Tveter, M. Unger, F. F. Valiev, D. Veberič, V. V. Vechernin, V. Volkov, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, A. Zviagina, R. Zwaska, and NA61/SHINE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Measurements of $$K^{*}(892)^0$$ K ∗ ( 892 ) 0 resonance production via its $$K^{+}\pi ^{-}$$ K + π - decay mode in inelastic p+p collisions at beam momenta 40 and 80 $$\text{ GeV }\!/\!c$$ GeV / c ( $$\sqrt{s_{NN}}=8.8$$ s NN = 8.8 and 12.3 $$\text{ GeV }$$ GeV ) are presented. The data were recorded by the NA61/SHINE hadron spectrometer at the CERN Super Proton Synchrotron. The template method was used to extract the $$K^{*}(892)^0$$ K ∗ ( 892 ) 0 signal. Transverse momentum and rapidity spectra were obtained. The mean multiplicities of $$K^{*}(892)^0$$ K ∗ ( 892 ) 0 mesons were found to be $$(35.1 \pm 1.3 \mathrm {(stat)} \pm 3.6 \mathrm {(sys))} \cdot 10^{-3}$$ ( 35.1 ± 1.3 ( stat ) ± 3.6 ( sys ) ) · 10 - 3 at 40 $$\text{ GeV }\!/\!c$$ GeV / c and $$(58.3 \pm 1.9 \mathrm {(stat)} \pm 4.9 \mathrm {(sys))} \cdot 10^{-3}$$ ( 58.3 ± 1.9 ( stat ) ± 4.9 ( sys ) ) · 10 - 3 at 80 $$\text{ GeV }\!/\!c$$ GeV / c . The NA61/SHINE results are compared with the Epos1.99 and Hadron Resonance Gas models as well as with world data. The transverse mass spectra of $$K^{*}(892)^0$$ K ∗ ( 892 ) 0 mesons and other particles previously reported by NA61/SHINE were fitted within the Blast-Wave model. The transverse flow velocities are close to 0.1–0.2 of the speed of light and are significantly smaller than the ones determined in heavy nucleus-nucleus interactions at the same beam momenta.

Published
2022
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40. $$K^{0}_{S}$$ K S 0 meson production in inelastic p+p interactions at 158 $$\text{ GeV }/c$$ GeV / c beam momentum measured by NA61/SHINE at the CERN SPS

Author

A. Acharya, H. Adhikary, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, V. Babkin, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, Y. Bondar, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, M. Koziel, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, Y. Nagai, M. Naskręt, V. Ozvenchuk, O. Panova, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, M. Unger, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, R. Zwaska, and NA61/SHINE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The production of $$K^{0}_{S}$$ K S 0 mesons in inelastic p+p collisions at beam momentum 158 $$\text{ GeV }/c$$ GeV / c ( $$\sqrt{s_{NN}}=17.3$$ s NN = 17.3 $$\text{ GeV }$$ GeV ) was measured with the NA61/SHINE spectrometer at the CERN Super Proton Synchrotron. Double-differential distributions were obtained in transverse momentum and rapidity. The mean multiplicity of $$K^{0}_{S}$$ K S 0 was determined to be $$0.162 \pm 0.001 (stat.) \pm 0.011 (sys.)$$ 0.162 ± 0.001 ( s t a t . ) ± 0.011 ( s y s . ) . The results on $$K^{0}_{S}$$ K S 0 production are compared with model predictions (EPOS 1.99, SMASH 2.0, PHSD and UrQMD 3.4 models) as well as with published world data.

Published
2022
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41. Switch from abiraterone + prednisone to abiraterone + dexamethasone after PSA progression under abiraterone + prednisone in asymptomatic metastatic castration-resistant prostate cancer (mCRPC) patients

Author

Rafael Sanchez-Salas, B. Poullennec, X. Cathelineau, Eric Barret, C. Fenioux, Christophe Louvet, Dominique Prapotnich, Stanislas Ropert, Annick Mombet, Mostefa Bennamoun, M. Ung, N. Cathala, and M.-L. Joulia

Subjects
Oncology, medicine.medical_specialty, business.industry, PSA PROGRESSION, Hematology, Castration resistant, medicine.disease, Asymptomatic, Abiraterone, chemistry.chemical_compound, Prostate cancer, chemistry, Prednisone, Internal medicine, medicine, medicine.symptom, business, Dexamethasone, medicine.drug
Published
2016

42. The energy spectrum of cosmic rays beyond the turn-down around $$\varvec{10^{17}}$$ 10 17 eV as measured with the surface detector of the Pierre Auger Observatory

Author

P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, K. S. Caballero-Mora, L. Caccianiga, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, M. del Río, O. Deligny, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, D. dos Santos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, N. Karastathis, B. Keilhauer, J. Kemp, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, N. Kunka, B. L. Lago, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, J. Pawlowsky, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, A. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, C. Watanabe, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, and Pierre Auger Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.

Published
2021
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43. Measurements of $${\Xi \left( 1530\right) ^{0}} $$ Ξ 1530 0 and $${\overline{\Xi }\left( 1530\right) ^{0}} $$ Ξ ¯ 1530 0 production in proton–proton interactions at $$\sqrt{s_{NN}}$$ s NN = 17.3 $$\text{ GeV }$$ GeV in the NA61/SHINE experiment

Author

A. Acharya, H. Adhikary, K. K. Allison, N. Amin, E. V. Andronov, T. Antićić, V. Babkin, Y. Balkova, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, Y. Nagai, M. Naskręt, V. Ozvenchuk, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, R. Ulrich, M. Unger, M. Urbaniak, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, R. Zwaska, and NA61/SHINE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Double-differential yields of $${\Xi \left( 1530\right) ^{0}} $$ Ξ 1530 0 and $${\overline{\Xi }\left( 1530\right) ^{0}} $$ Ξ ¯ 1530 0 resonances produced in p+p interactions were measured at a laboratory beam momentum of 158 $$\text{ GeV }\!/\!c$$ GeV / c . This measurement is the first of its kind in p+p interactions below LHC energies. It was performed at the CERN SPS by the NA61/SHINE collaboration. Double-differential distributions in rapidity and transverse momentum were obtained from a sample of $$26\times 10^6$$ 26 × 10 6 inelastic events. The spectra are extrapolated to full phase space resulting in mean multiplicity of $${\Xi \left( 1530\right) ^{0}} $$ Ξ 1530 0 ( $$6.73 \pm 0.25\pm 0.67)\times 10^{-4}$$ 6.73 ± 0.25 ± 0.67 ) × 10 - 4 and $${\overline{\Xi }\left( 1530\right) ^{0}} $$ Ξ ¯ 1530 0 ( $$2.71 \pm 0.18\pm 0.18)\times 10^{-4}$$ 2.71 ± 0.18 ± 0.18 ) × 10 - 4 . The rapidity and transverse momentum spectra and mean multiplicities were compared to predictions of string-hadronic and statistical model calculations.

Published
2021
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44. Erratum to: Measurements of $${\Xi }{^-} $$ Ξ - and $$\overline{\Xi }{^+} $$ Ξ ¯ + production in proton–proton interactions at $$\sqrt{s_{NN}}$$ s NN = 17.3 $$\hbox {Ge}\hbox {V}$$ Ge in the NA61/SHINE experiment

Author

A. Aduszkiewicz, E. V. Andronov, T. Antićić, V. Babkin, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, M. Koziel, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, S. Mrówczyński, Y. Nagai, M. Naskręt, V. Ozvenchuk, V. Paolone, O. Petukhov, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, R. Ulrich, M. Unger, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, Z. Włodarczyk, K. Wojcik, O. Wyszyński, E. D. Zimmerman, R. Zwaska, and NA61/SHINE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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45. Spectra and mean multiplicities of $$\pi ^{-}$$ π - in central $${}^{40}$$ 40 Ar+ $${}^{45}$$ 45 Sc collisions at 13A, 19A, 30A, 40A, 75A and 150 $$A\,\text{ Ge }\text{ V }\!/\!\textit{c}$$ A Ge V / c beam momenta measured by the NA61/SHINE spectrometer at the CERN SPS

Author

A. Acharya, H. Adhikary, K. K. Allison, E. V. Andronov, T. Antićić, V. Babkin, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, M. Koziel, B. Kozłowski, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H. -J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, Y. Nagai, M. Naskręt, V. Ozvenchuk, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, R. Ulrich, M. Unger, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, K. Wójcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The physics goal of the strong interaction program of the NA61/SHINE experiment at the CERN Super Proton Synchrotron (SPS) is to study the phase diagram of hadronic matter by a scan of particle production in collisions of nuclei with various sizes at a set of energies covering the SPS energy range. This paper presents differential inclusive spectra of transverse momentum, transverse mass and rapidity of $$\pi ^{-}$$ π - mesons produced in central $${}^{40}$$ 40 Ar+ $${}^{45}$$ 45 Sc collisions at beam momenta of 13A, 19A, 30A, 40A, 75A and 150 $$A\,\text{ Ge }\text{ V }\!/\!\textit{c}$$ A Ge V / c . Energy and system size dependence of parameters of these distributions – mean transverse mass, the inverse slope parameter of transverse mass spectra, width of the rapidity distribution and mean multiplicity – are presented and discussed. Furthermore, the dependence of the ratio of the mean number of produced pions to the mean number of wounded nucleons on the collision energy was derived. The results are compared to predictions of several models.

Published
2021
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46. Measurements of multiplicity fluctuations of identified hadrons in inelastic proton–proton interactions at the CERN Super Proton Synchrotron

Author

A. Acharya, H. Adhikary, A. Aduszkiewicz, K. K. Allison, E. V. Andronov, T. Antićić, V. Babkin, M. Baszczyk, S. Bhosale, A. Blondel, M. Bogomilov, A. Brandin, A. Bravar, W. Bryliński, J. Brzychczyk, M. Buryakov, O. Busygina, A. Bzdak, H. Cherif, M. Ćirković, M. Csanad, J. Cybowska, T. Czopowicz, A. Damyanova, N. Davis, M. Deliyergiyev, M. Deveaux, A. Dmitriev, W. Dominik, P. Dorosz, J. Dumarchez, R. Engel, G. A. Feofilov, L. Fields, Z. Fodor, A. Garibov, M. Gaździcki, O. Golosov, V. Golovatyuk, M. Golubeva, K. Grebieszkow, F. Guber, A. Haesler, S. N. Igolkin, S. Ilieva, A. Ivashkin, S. R. Johnson, K. Kadija, N. Kargin, E. Kashirin, M. Kiełbowicz, V. A. Kireyeu, V. Klochkov, V. I. Kolesnikov, D. Kolev, A. Korzenev, V. N. Kovalenko, S. Kowalski, M. Koziel, A. Krasnoperov, W. Kucewicz, M. Kuich, A. Kurepin, D. Larsen, A. László, T. V. Lazareva, M. Lewicki, K. Łojek, V. V. Lyubushkin, M. Maćkowiak-Pawłowska, Z. Majka, B. Maksiak, A. I. Malakhov, A. Marcinek, A. D. Marino, K. Marton, H.-J. Mathes, T. Matulewicz, V. Matveev, G. L. Melkumov, A. O. Merzlaya, B. Messerly, Ł. Mik, S. Morozov, Y. Nagai, M. Naskręt, V. Ozvenchuk, V. Paolone, O. Petukhov, I. Pidhurskyi, R. Płaneta, P. Podlaski, B. A. Popov, B. Porfy, M. Posiadała-Zezula, D. S. Prokhorova, D. Pszczel, S. Puławski, J. Puzović, M. Ravonel, R. Renfordt, D. Röhrich, E. Rondio, M. Roth, B. T. Rumberger, M. Rumyantsev, A. Rustamov, M. Rybczynski, A. Rybicki, S. Sadhu, A. Sadovsky, K. Schmidt, I. Selyuzhenkov, A. Yu. Seryakov, P. Seyboth, M. Słodkowski, P. Staszel, G. Stefanek, J. Stepaniak, M. Strikhanov, H. Ströbele, T. Šuša, A. Taranenko, A. Tefelska, D. Tefelski, V. Tereshchenko, A. Toia, R. Tsenov, L. Turko, R. Ulrich, M. Unger, D. Uzhva, F. F. Valiev, D. Veberič, V. V. Vechernin, A. Wickremasinghe, K. Wojcik, O. Wyszyński, A. Zaitsev, E. D. Zimmerman, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Measurements of multiplicity fluctuations of identified hadrons produced in inelastic p+p interactions at 31, 40, 80, and 158 $$\text {Ge}\text {V}/c$$ Ge / c beam momentum are presented. Three different measures of multiplicity fluctuations are used: the scaled variance $$\omega $$ ω and strongly intensive measures $$\Sigma $$ Σ and $$\Delta $$ Δ . These fluctuation measures involve second and first moments of joint multiplicity distributions. Data analysis is preformed using the Identity method which corrects for incomplete particle identification. Strongly intensive quantities are calculated in order to allow for a direct comparison to corresponding results on nucleus–nucleus collisions. The results for different hadron types are shown as a function of collision energy. A comparison with predictions of string-resonance Monte-Carlo models: Epos, Smash and Venus, is also presented.

Published
2021
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47. The cosmic muon and detector simulation framework of the extreme energy events (EEE) experiment

Author

M. Abbrescia, C. Avanzini, L. Baldini, R. Baldini Ferroli, G. Batignani, M. Battaglieri, S. Boi, E. Bossini, F. Carnesecchi, C. Cicalò, L. Cifarelli, F. Coccetti, E. Coccia, A. Corvaglia, D. De Gruttola, S. De Pasquale, F. Fabbri, A. Fulci, L. Galante, M. Garbini, G. Gemme, I. Gnesi, S. Grazzi, D. Hatzifotiadou, P. La Rocca, Z. Liu, G. Mandaglio, G. Maron, M. N. Mazziotta, A. Mulliri, R. Nania, F. Noferini, F. Nozzoli, F. Palmonari, M. Panareo, M. P. Panetta, R. Paoletti, C. Pellegrino, O. Pinazza, C. Pinto, S. Pisano, F. Riggi, G. Righini, C. Ripoli, M. Rizzi, G. Sartorelli, E. Scapparone, M. Schioppa, A. Scribano, M. Selvi, G. Serri, S Squarcia, M. Taiuti, G. Terreni, A. Trifirò, M. Trimarchi, A. S. Triolo, C. Vistoli, L. Votano, M. Ungaro, M. C. S. Williams, A. Zichichi, and R. Zuyeuski

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract This paper describes the simulation framework of the extreme energy events (EEE) experiment. EEE is a network of cosmic muon trackers, each made of three multi-gap resistive plate chambers (MRPC), able to precisely measure the absolute muon crossing time and the muon integrated angular flux at the ground level. The response of a single MRPC and the combination of three chambers have been implemented in a GEANT4-based framework (GEMC) to study the telescope response. The detector geometry, as well as details about the surrounding materials and the location of the telescopes have been included in the simulations in order to realistically reproduce the experimental set-up of each telescope. A model based on the latest parametrization of the cosmic muon flux has been used to generate single muon events. After validating the framework by comparing simulations to selected EEE telescope data, it has been used to determine detector parameters not accessible by analysing experimental data only, such as detection efficiency, angular and spatial resolution.

Published
2021
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50. Epilogue

Author

M. Unger, Daniel

Published
2019

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