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1. Zn-doped titania nanoparticles as building blocks for solid foam filters of water and air via photocatalytic oxidation

Author: M. Vaccari, M. Cremona, D. Orsi, V. Lorusso, A. Baraldi, A. Bosio, D. Pontiroli, L. Liggieri, F. Ravera, E. Santini, and L. Cristofolini
Subjects: Photocatalytic oxidation (PCO), Titania nanoparticles, Air purification, Water purification, Porous materials, Solid foams, Chemistry, QD1-999
Abstract: Photocatalytic oxidation (PCO) could provide energy-efficient purification of water and air. Its efficacy is constrained mainly by limited photocatalytic activity and active surface. To address both, solid foams with hierarchic porous structures spanning multiple length-scales, stabilized by photocatalytic Zn-doped titania nanoparticles (NP) were synthesized and tested. The NP were characterized by SEM, EDS, DLS, XRD, Raman and UV–Vis spectroscopies. Solid foams were stabilized by NP complexes with cationic surfactants. The foam morphology was characterized and photocatalytic activity was demonstrated in water. The present work paves the way for the development of efficient systems for air and water purification in demanding technological sectors, such as aerospace.
Published: 2022
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2. Effects of marine traffic on sediment erosion and accumulation in ports: a new model-based methodology

Author: A. Guarnieri, S. Saremi, A. Pedroncini, J. H. Jensen, S. Torretta, M. Vaccari, and C. Vincenzi
Subjects: Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract: The action of propeller-induced jets on the seabed of ports can cause erosion and the deposition of sediment around the port basin, potentially significantly impacting the bottom topography over the medium and long term. If such dynamics are constantly repeated for long periods, a drastic reduction in ships' clearance can result through accretion, or the stability and duration of structures can be threatened through erosion. These sediment-related processes present port management authorities with problems, both in terms of navigational safety and the optimization of management and maintenance activities of the port's bottom and infrastructure. In this study, which is based on integrated numerical modeling, we examine the hydrodynamics and the related bottom sediment erosion and accumulation patterns induced by the action of vessel propellers in the passenger port of Genoa, Italy. The proposed new methodology offers a state-of-the-art science-based tool that can be used to optimize and efficiently plan port management and seabed maintenance.
Published: 2021
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3. Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

Author: M. D. Fahlberg, R. V. Blair, L. A. Doyle-Meyers, C. C. Midkiff, G. Zenere, K. E. Russell-Lodrigue, C. J. Monjure, E. H. Haupt, T. P. Penney, G. Lehmicke, B. M. Threeton, N. Golden, P. K. Datta, C. J. Roy, R. P. Bohm, N. J. Maness, T. Fischer, J. Rappaport, and M. Vaccari
Subjects: Science
Abstract: Here, Fahlberg et al. describe the cellular immune response during acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates. The study identifies associations of monocytes and macrophage subtypes in lungs with disease outcome, IL-6 and IL-10 ratio in plasma, and viral replication in bronchial brushes.
Published: 2020
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4. Reuse of Hydrocarbon-Contaminated Sludge from Soil Washing Process: Issues and Perspectives

Author: M. Vaccari, M. Collivignarelli, and M. Canato
Subjects: Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract: Soil washing is a remediation technology commonly used to treat soil contaminated by total petroleum hydrocarbons (TPHs) (Seyed Razavi et al., 2012). Nowadays in Italy there are about ten plants, mainly placed in the north of the country. After treatment, coarse materials (i.e. gravel and sand) are cleaned and can be reused, e.g. as aggregate for concrete production; contaminants are concentrated in the filter-pressed sludge containing fine grains (i.e silt and clay), which is usually landfilled. This paper analyses different alternatives for sludge reuse at an industrial scale in Italy; the main normative and technical constraints are presented and discussed. In addition, the preliminary results of a lab-scale experimentation aimed at investigating the treatability of soil washing residues by wet oxidation are presented. The reuse and valorisation of soil washing originated sludge is desirable not only from the economic point of view but also because Italian and European legislation put waste recycling as a priority. Several tens of thousands of tons of sludge are produced and landfilled in Italy every year; they represent materials which could be exploited at industrial scale in place of virgin silt and clay to produce stabilised soil for road construction or bricks in brick works. Sludge reuse for cement production is possible, too, but it is probably more expensive. The use of raw sludge produced in soil washing plants implies a potential risk of environmental contamination therefore the basic condition for sludge recovery and reuse is its decontamination, which can be theoretically obtained by thermal desorption, solvent extraction or chemical oxidation. Wet oxidation tests executed by the authors indicate that such a process is potentially applicable. 98 % removal efficiency of TPHs was obtained in a lab-scale reactor setting temperature, treatment time and initial oxygen pressure to 250 °C, 30 min and 20 atm, respectively. Further tests will be carried out in order to identify the most favourable and cheapest treatment conditions.
Published: 2012
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5. MIGHTEE: the nature of the radio-loud AGN population

Author: I H Whittam, M J Jarvis, C L Hale, M Prescott, L K Morabito, I Heywood, N J Adams, J Afonso, Fangxia An, Y Ao, R A A Bowler, J D Collier, R P Deane, J Delhaize, B Frank, M Glowacki, P W Hatfield, N Maddox, L Marchetti, A M Matthews, I Prandoni, S Randriamampandry, Z Randriamanakoto, D J B Smith, A R Taylor, N L Thomas, and M Vaccari
Published: 2022
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6. HELP: the Herschel Extragalactic Legacy Project

Author: R Shirley, K Duncan, M C Campos Varillas, P D Hurley, K Małek, Y Roehlly, M W L Smith, H Aussel, T Bakx, V Buat, D Burgarella, N Christopher, S Duivenvoorden, S Eales, A Efstathiou, E A González Solares, M Griffin, M Jarvis, B Lo Faro, L Marchetti, I McCheyne, A Papadopoulos, K Penner, E Pons, M Prescott, E Rigby, H Rottgering, A Saxena, J Scudder, M Vaccari, L Wang, and S J Oliver
Published: 2021
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7. A Spitzer survey of Deep Drilling Fields to be targeted by the Vera C. Rubin Observatory Legacy Survey of Space and Time

Author: M Lacy, J A Surace, D Farrah, K Nyland, J Afonso, W N Brandt, D L Clements, C D P Lagos, C Maraston, J Pforr, A Sajina, M Sako, M Vaccari, G Wilson, D R Ballantyne, W A Barkhouse, R Brunner, R Cane, T E Clarke, M Cooper, A Cooray, G Covone, C D’Andrea, A E Evrard, H C Ferguson, J Frieman, V Gonzalez-Perez, R Gupta, E Hatziminaoglou, J Huang, P Jagannathan, M J Jarvis, K M Jones, A Kimball, C Lidman, L Lubin, L Marchetti, P Martini, R G McMahon, S Mei, H Messias, E J Murphy, J A Newman, R Nichol, R P Norris, S Oliver, I Perez-Fournon, W M Peters, M Pierre, E Polisensky, G T Richards, S E Ridgway, H J A Röttgering, N Seymour, R Shirley, R Somerville, M A Strauss, N Suntzeff, P A Thorman, E van Kampen, A Verma, R Wechsler, and W M Wood-Vasey
Published: 2020
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8. Deep ASKAP EMU Survey of the GAMA23 field: Properties of radio sources

Author: Gülay Gürkan, I Prandoni, A O’Brien, W Raja, L Marchetti, M Vaccari, S Driver, E Taylor, T Franzen, M J I Brown, S Shabala, H Andernach, A M Hopkins, R P Norris, D Leahy, M Bilicki, H Farajollahi, T Galvin, G Heald, B S Koribalski, T An, and K Warhurst
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present the Australian Square Kilometre Array Pathfinder (ASKAP) observations of the Galaxy and Mass Assembly (GAMA)-23h field. The survey was carried out at 887.5 MHz and covers a 83 square degree field. We imaged the calibrated visibility data, taken as part of the Evolutionary Mapping of Universe (EMU) Early Science Programme, using the latest version of the ASKAPSoft pipeline. The final mosaic has an angular resolution of 10 arcsec and a central rms noise of around 38 $\mu$Jy beam$^{-1}$. The derived radio source catalogue has 39812 entries above a peak flux density threshold of 5$\sigma$. We searched for the radio source host galaxy counterparts using the GAMA spectroscopic (with an i-band magnitude limit of 19.2 mag) and multi-wavelength catalogues that are available as part of the collaboration. We identified hosts with GAMA spectroscopic redshifts for 5934 radio sources. We describe the data reduction, imaging, and source identification process, and present the source counts. Thanks to the wide area covered by our survey, we obtain very robust counts down to 0.2 mJy. ASKAP's exceptional survey speed, providing efficient, sensitive and high resolution mapping of large regions of the sky in conjunction with the multi-wavelength data available for the GAMA23 field, allowed us to discover 63 giant radio galaxies. The data presented here demonstrate the excellent capabilities of ASKAP in the pre-SKA era., Comment: 18 pages, 15 figures, accepted by MNRAS
Published: 2022
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9. COSMOS2020: a panchromatic view of the universe to z 10 from two complementary catalogs

Author: J. R. Weaver, O. B. Kauffmann, O. Ilbert, H. J. McCracken, A. Moneti, S. Toft, G. Brammer, M. Shuntov, I. Davidzon, B. C. Hsieh, C. Laigle, A. Anastasiou, C. K. Jespersen, J. Vinther, P. Capak, C. M. Casey, C. J. R. McPartland, B. Milvang-Jensen, B. Mobasher, D. B. Sanders, L. Zalesky, S. Arnouts, H. Aussel, J. S. Dunlop, A. Faisst, M. Franx, L. J. Furtak, J. P. U. Fynbo, K. M. L. Gould, T. R. Greve, S. Gwyn, J. S. Kartaltepe, D. Kashino, A. M. Koekemoer, V. Kokorev, O. Le Fèvre, S. Lilly, D. Masters, G. Magdis, V. Mehta, Y. Peng, D. A. Riechers, M. Salvato, M. Sawicki, C. Scarlata, N. Scoville, R. Shirley, J. D. Silverman, A. Sneppen, V. Smolc̆ić, C. Steinhardt, D. Stern, M. Tanaka, Y. Taniguchi, H. I. Teplitz, M. Vaccari, W.-H. Wang, G. Zamorani, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Weaver, JR [0000-0003-1614-196X], Kauffmann, OB [0000-0001-5283-4662], Ilbert, O [0000-0002-7303-4397], McCracken, HJ [0000-0002-9489-7765], Toft, S [0000-0003-3631-7176], Brammer, G [0000-0003-2680-005X], Shuntov, M [0000-0002-7087-0701], Davidzon, I [0000-0002-2951-7519], Hsieh, BC [0000-0001-5615-4904], Anastasiou, A [0000-0001-8558-7709], Jespersen, CK [0000-0002-8896-6496], Vinther, J [0000-0002-4418-752X], Capak, P [0000-0003-3578-6843], Casey, CM [0000-0002-0930-6466], McPartland, CJR [0000-0003-0639-025X], Milvang-Jensen, B [0000-0002-2281-2785], Sanders, DB [0000-0002-1233-9998], Zalesky, L [0000-0001-5680-2326], Faisst, A [0000-0002-9382-9832], Franx, M [0000-0002-8871-3026], Furtak, LJ [0000-0001-6278-032X], Fynbo, JPU [0000-0002-8149-8298], Gould, KML [0000-0003-4196-5960], Greve, TR [0000-0002-2554-1837], Gwyn, S [0000-0001-8221-8406], Kartaltepe, JS [0000-0001-9187-3605], Kashino, D [0000-0001-9044-1747], Koekemoer, AM [0000-0002-6610-2048], Kokorev, V [0000-0002-5588-9156], Le Fèvre, O [0000-0001-5891-2596], Lilly, S [0000-0002-6423-3597], Masters, D [0000-0001-5382-6138], Magdis, G [0000-0002-4872-2294], Mehta, V [0000-0001-7166-6035], Riechers, DA [0000-0001-9585-1462], Salvato, M [0000-0001-7116-9303], Sawicki, M [0000-0002-7712-7857], Scarlata, C [0000-0002-9136-8876], Scoville, N [0000-0002-0438-3323], Shirley, R [0000-0002-1114-0135], Sneppen, A [0000-0002-5460-6126], Smolc̆ić, V [0000-0002-3893-8614], Steinhardt, C [0000-0003-3780-6801], Stern, D [0000-0003-2686-9241], Tanaka, M [0000-0002-5011-5178], Taniguchi, Y [0000-0003-2247-3741], Teplitz, HI [0000-0002-7064-5424], Vaccari, M [0000-0002-6748-0577], Wang, W-H [0000-0003-2588-1265], Zamorani, G [0000-0002-2318-301X], and Apollo - University of Cambridge Repository
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Astrophysics - astrophysics of galaxies, Astrophysics - cosmology and nongalactic astrophysics, FOS: Physical sciences, 5109 Space Sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Galaxies and Cosmology, Universe, panchromatic view, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Galaxy Astrophysics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Earth and Planetary Astrophysics, 51 Physical Sciences
Abstract: The Cosmic Evolution Survey (COSMOS) has become a cornerstone of extragalactic astronomy. Since the last public catalog in 2015, a wealth of new imaging and spectroscopic data has been collected in the COSMOS field. This paper describes the collection, processing, and analysis of this new imaging data to produce a new reference photometric redshift catalog. Source detection and multi-wavelength photometry is performed for 1.7 million sources across the $2\,\mathrm{deg}^{2}$ of the COSMOS field, $\sim$966,000 of which are measured with all available broad-band data using both traditional aperture photometric methods and a new profile-fitting photometric extraction tool, The Farmer, which we have developed. A detailed comparison of the two resulting photometric catalogs is presented. Photometric redshifts are computed for all sources in each catalog utilizing two independent photometric redshift codes. Finally, a comparison is made between the performance of the photometric methodologies and of the redshift codes to demonstrate an exceptional degree of self-consistency in the resulting photometric redshifts. The $i, Comment: 39 pages, 21 figures, accepted for publication in The Astrophysical Journal Supplement Series. Production of IRAC mosaics are presented in Moneti et al. "Euclid Preparation: XVIII. Cosmic Dawn Survey. Spitzer observations of the Euclid deep fields and calibration fields" which has been posted simultaneously. Catalogs can be accessed online now at https://cosmos2020.calet.org
Published: 2022
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10. The star formation rates of QSOs

Author: M Symeonidis, N Maddox, M J Jarvis, M J Michałowski, P Andreani, D L Clements, G De Zotti, S Duivenvoorden, J Gonzalez-Nuevo, E Ibar, R J Ivison, L Leeuw, M J Page, R Shirley, M W L Smith, and M Vaccari
Subjects: Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astronomy and Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics::Galaxy Astrophysics
Abstract: We examine the far-IR properties of a sample of 5391 optically selected QSOs in the 0.544.7, using SPIRE data from Herschel-ATLAS. We split the sample in a grid of 74 luminosity-redshift bins and compute the average optical-infrared spectral energy distribution (SED) in each bin. By normalising an intrinsic AGN template to the AGN optical power (at 5100A) we decompose the total infrared emission (L_IR; 8-1000um) into an AGN (L_IR,AGN) and star-forming component (L_IR,SF). We find that the AGN contribution to L_IR increases as a function of AGN power which manifests as a reduction of the `far-IR bump' in the average QSO SEDs. We note that L_IR,SF does not correlate with AGN power; the mean star formation rates (SFRs) of AGN host galaxies are a function of redshift only and they range from ~6 Msun/yr at z~0 to a plateau of, Comment: 20 pages, 10 figures, accepted for publication in MNRAS
Published: 2022

11. The LOFAR two-metre sky survey deep fields.: The mass dependence of the far-infrared radio correlation at 150 MHz using deblended Herschel fluxes

Author: I. McCheyne, S. Oliver, M. Sargent, R. Kondapally, D. Smith, P. Haskell, K. Duncan, P. N. Best, J. Sabater, M. Bonato, G. Calistro Rivera, R. K. Cochrane, M. C. Campos Varillas, P. Hurley, S. K. Leslie, K. Małek, M. Magliocchetti, I. Prandoni, S. Read, H. J. A. Rottgering, C. Tasse, M. Vaccari, L. Wang, Astronomy, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Galaxy: evolution, radio continuum: galaxies, surveys, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Galaxy evolution, infrared galaxies, Astronomy and Astrophysics, Infrared: galaxies, catalogs
Abstract: The far-infrared radio correlation (FIRC) is one of the strongest correlations in astronomy, yet a model that explains this comprehensively does not exist. The new LOFAR all Sky Survey (LoTSS) deep field, ELAIS-N1, allows exploration of this relation in previously unexplored regions of parameter space of radio frequency (150 MHz), luminosity (L150 24.7), redshift (z ∼ 1), and stellar mass M* 11.4. We present accurate deblended far-infrared (FIR) flux measurements with robust errors at 24, 100, 160, 250, 350, and 500 μm from Spitzer and the Herschel Space Observatory using XID+. We find that the FIRC has a strong mass dependence, the evolution of which takes the form qTIR(M*) = (2.00 ± 0.01)+(−0.22 ± 0.02)(log(M/M*)−10.05). This matches recent findings in regards to the star formation rate–radio luminosity relation at 150 MHz and results from radio observations in COSMOS at 1.4 GHz with the Jansky Very Large Array (JVLA). Our results provide tighter constraints on the low-redshift end of the FIRC and at lower frequency than the COSMOS observations. In addition, we find a mild evolution with redshift, with a best fit relation qTIR(z) = (1.94 ± 0.01)(1 + z)−0.04 ± 0.01. This evolution is shallower than that suggested by previous results at 150 MHz with the differences explained by the fact that previous studies did not account for the mass dependence. Finally, we present deblended FIR fluxes for 79 609 galaxies across the LoTSS deep fields: Boötes, ELAIS-N1, and Lockman Hole.
Published: 2022
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12. Erratum: 'Identification of Single Spectral Lines in Large Spectroscopic Surveys Using UMLAUT: an Unsupervised Machine-learning Algorithm Based on Unbiased Topology' (2021, ApJS, 257, 67)

Author: I. Baronchelli, C. M. Scarlata, L. Rodríguez-Muñoz, M. Bonato, L. Morselli, M. Vaccari, R. Carraro, L. Barrufet, A. Henry, V. Mehta, G. Rodighiero, A. Baruffolo, M. Bagley, A. Battisti, J. Colbert, Y. S. Dai, M. De Pascale, H. Dickinson, M. Malkan, C. Mancini, M. Rafelski, and H. I. Teplitz
Subjects: Space and Planetary Science, Astronomy and Astrophysics
Published: 2022
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13. 'COVID Toes' After mRNA COVID-19 Vaccines

Author: John M. Kelso, Alvin B. Coda, Richard M. Keating, and Dana M. Vaccari
Subjects: Messenger RNA, 2019-20 coronavirus outbreak, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, RNA, Toes, Virology, Humans, Immunology and Allergy, Medicine, Images in Allergy, RNA, Messenger, business
Published: 2021
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14. Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Author: Kamarajah, S. K. Nepogodiev, D. Bekele, A. Cecconello, I. and Evans, R. P. T. Guner, A. Gossage, J. A. Harustiak, T. and Hodson, J. Isik, A. Kidane, B. Leon-Takahashi, A. M. and Mahendran, H. A. Negoi, I. Okonta, K. E. Rosero, G. and Sayyed, R. H. Singh, P. Takeda, F. R. van Hillegersberg, R. and Vohra, R. S. White, R. E. Griffiths, E. A. Alderson, D. and Bundred, J. Evans, R. P. T. Gossage, J. Griffiths, E. A. and Jefferies, B. Kamarajah, S. K. McKay, S. Mohamed, I. and Nepogodiev, D. Siaw-Acheampong, K. Singh, P. van Hillegersberg, R. Vohra, R. Wanigasooriya, K. Whitehouse, T. and Gjata, A. Moreno, J. I. Takeda, F. R. Kidane, B. and Guevara, Castro R. Harustiak, T. Bekele, A. Kechagias, A. and Gockel, I. Kennedy, A. Da Roit, A. Bagajevas, A. and Azagra, J. S. Mahendran, H. A. Mejia-Fernandez, L. and Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. and Sampaio, A. S. Negoi, I. Blanco, R. Wallner, B. and Schneider, P. M. Hsu, P. K. Isik, A. Gananadha, S. and Wills, V. Devadas, M. Duong, C. Talbot, M. Hii, M. W. and Jacobs, R. Andreollo, N. A. Johnston, B. Darling, G. and Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. and Gaedcke, J. Reim, D. Izbicki, J. Egberts, J. H. and Dikinis, S. Kjaer, D. W. Larsen, M. H. Achiam, M. P. and Saarnio, J. Theodorou, D. Liakakos, T. Korkolis, D. P. and Robb, W. B. Collins, C. Murphy, T. Reynolds, J. Tonini, V. Migliore, M. Bonavina, L. Valmasoni, M. Bardini, R. and Weindelmayer, J. Terashima, M. White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. Medina-Franco, H. and Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. van Hillegersberg, R. Beban, G. Babor, R. Gordon, A. and Rossaak, J. I. Pal, K. M. I. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. Bjelovic, M. So, J. B. Y. Gacevski, G. Loureiro, C. Pera, M. and Bianchi, A. Moreno, Gijon M. Martin Fernandez, J. Carrera, M. S. Trugeda Vallve-Bernal, M. Pascual, M. A. Citores and Elmahi, S. Halldestam, I. Hedberg, J. Monig, S. and Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, M. B. Colak, E. Sevinc, B. Hindmarsh, A. Khan, I. Khoo, D. Byrom, R. Gokhale, J. Wilkerson, P. Jain, P. Chan, D. and Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. and Higgs, S. Gossage, J. Nijjar, R. Viswanath, Y. K. S. and Turner, P. Dexter, S. Boddy, A. Allum, W. H. Oglesby, S. and Cheong, E. Beardsmore, D. Vohra, R. Maynard, N. and Berrisford, R. Mercer, S. Puigt, S. Melhadot, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. Al-Bahrani, A. and Bryce, G. Thomas, M. Arndt, A. T. Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. Mosse, C. Salim, J. and Cheah, S. Wright, T. Cerdeira, M. P. McQuillan, P. and Richardson, M. Liem, H. Spillane, J. Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. Bassari, R. Bui, H. Cecconello, I. Sallum, R. A. A. da Rocha, J. R. M. and Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. Shea, P. Yeung, J. Allison, F. Carroll, P. Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. Beltran-Garcia, T. C. and Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. and Cortes, N. Cetares, C. Caceres, S. Duarte, S. Pazdro, A. and Snajdauf, M. Faltova, H. Sevcikova, M. Mortensen, P. B. and Katballe, N. Ingemann, T. Morten, B. Kruhlikava, I. and Ainswort, A. P. Stilling, N. M. Eckardt, J. Holm, J. and Thorsteinsson, M. Siemsen, M. Brandt, B. Nega, B. and Teferra, E. Tizazu, A. Kauppila, J. H. Koivukangas, V. and Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. and Golcher, H. Emons, G. Azizian, A. Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. and Boecher, U. Reeh, M. Triantafyllou, S. Schizas, D. and Michalinos, A. Mpali, E. Mpoura, M. Charalabopoulos, A. and Manatakis, D. K. Balalis, D. Bolger, J. Baban, C. and Mastrosimone, A. McAnena, O. Quinn, A. Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. and Donlon, N. Cervellera, M. Vaccari, S. Bianchini, S. and Sartarelli, L. Asti, E. Bernardi, D. Merigliano, S. and Provenzano, L. Scarpa, M. Saadeh, L. Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. De Pasqual, C. A. and Tsubosa, Y. Niihara, M. Irino, T. Makuuchi, R. and Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. Mwachiro, E. and AlShehab, D. Ahmed, H. A. Shebani, A. O. Elhadi, A. and Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. and Tan, Y. R. Thannimalai, S. Ho, C. A. Pang, W. S. and Tan, J. H. Basave, H. N. L. Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. Cords, C. Jansen, W. A. and Martijnse, I. Matthijsen, R. Bouwense, S. Klarenbeek, B. and Verstegen, M. van Workum, F. Ruurda, J. P. van der Sluis, P. C. de Maat, M. Evenett, N. Johnston, P. Patel, R. and MacCormick, A. Young, M. Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. Khalil, N. Haris, M. and Mirza, Z. U. Qudus, S. B. A. Sarwar, M. Z. Shehzadi, A. and Raza, A. Jhanzaib, M. H. Farmanali, J. Zakir, Z. and Shakeel, O. Nasir, I. Khattak, S. Baig, M. Noor, M. A. and Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. and Bernardes, A. Campos, J. C. Matos, H. Braga, T. and Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. Ciuce, C. Drasovean, R. Apostu, R. Ciuce, C. Paitici, S. Racu, A. E. and Obleaga, C. V. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V. Cordos, I. Birla, R. D. Predescu, D. Hoara, P. A. Tomsa, R. Shneider, V. Agasiev, M. Ganjara, I. and Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. Del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarezt, L. S. and Alvarez, L. S. Campos, P. V. Rendo, A. G. Garcia, S. S. and Santos, E. P. G. Martinez, E. T. Fernandez, Diaz Mj Magadan, Alvarez C. Concepcion, Martin V. Diaz, Lopez C. Rosat, Rodrigo A. Perez, Sanchez L. E. Bailon, Cuadrado M. Tinoco, Carrasco C. Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. and Mickael, C. Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. Karahan, O. Damburaci, N. Hardwickt, R. and Safranek, P. Sujendran, V. Bennett, J. Afzal, Z. and Shrotri, M. Chan, B. Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. Harris, A. Dobson, G. Davies, N. and Wilson, I. Mayo, D. Bennett, D. Young, R. Manby, P. and Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V. and Elshaer, A. Cowen, M. Menon, V. Tan, L. C. and McLaughlin, E. Koshy, R. Sharp, C. Brewer, H. Das, N. and Cox, M. Al Khyatt, W. Worku, D. Iqbal, R. Walls, L. and McGregor, R. Fullarton, G. Macdonald, A. MacKay, C. and Craig, C. Dwerryhouse, S. Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. Kelly, M. Davies, A. Di Maggio, F. McKay, S. Mistry, P. Singhal, R. Tucker, O. and Kapoulas, S. Powell-Brett, S. Davis, P. Bromley, G. and Watson, L. Verma, R. Ward, J. Shetty, V. Ball, C. and Pursnani, K. Sarela, A. Sue, Ling H. Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. Supramaniam, K. and Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. Moussa, O. and Kordzadeh, A. Lorenzi, B. Wilson, M. Patil, P. Noaman, I. Willem, J. Bouras, G. Evans, R. Singh, M. and Warrilow, H. Ahmad, A. Tewari, N. Yanni, F. Couch, J. and Theophilidou, E. Reilly, J. J. Singh, P. van Boxel, Gijs and Akbari, K. Zanotti, D. Sgromo, B. Sanders, G. and Wheatley, T. Ariyarathenam, A. Reece-Smith, A. Humphreys, L. and Choh, C. Carter, N. Knight, B. Pucher, P. and Athanasiou, A. Mohamed, I. Tan, B. Abdulrahman, M. and Vickers, J. Akhtar, K. Chaparala, R. Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. Tamhankar, A. Wyman, A. and Walker, R. Grace, B. Abbassi, N. Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. Escofet, X. Powell, A. and Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. and Ben-Younes, H. Mccormack, K. Makey, I. A. Karush, M. K. and Seder, C. W. Liptay, M. J. Chmielewski, G. Rosato, E. L. and Berger, A. C. Zheng, R. Okolo, E. Singh, A. Scott, C. D. and Weyant, M. J. Mitchell, J. D. Oesophago-Gastric Anastomotic
Abstract: Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method: This international multi-center prospective study across 137 hospitals in 41 countries included patients who underwent an esophagectomy for esophageal cancer, with 90-day follow-up. The main explanatory variable was country income, defined according to the World Bank Data classification. The primary outcome was 90-day postoperative mortality, and secondary outcomes were composite leaks (anastomotic leak or conduit necrosis) and major complications (Clavien-Dindo Grade III-V). Multivariable generalized estimating equation models were used to produce adjusted odds ratios (ORs) and 95% confidence intervals (CI95%). Results: Between April 2018 to December 2018, 2247 patients were included. Patients from HIC were more significantly older, with higher ASA grade, and more advanced tumors. Patients from LMIC had almost three-fold increase in 90-day mortality, compared to HIC (9.4% vs 3.7%, p < 0.001). On adjusted analysis, LMIC were independently associated with higher 90-day mortality (OR: 2.31, CI95%: 1.17-4.55, p = 0.015). However, LMIC were not independently associated with higher rates of anastomotic leaks (OR: 1.06, CI95%: 0.57-1.99, p = 0.9) or major complications (OR: 0.85, CI95%: 0.54-1.32, p = 0.5), compared to HIC. Conclusion: Resections in LMIC were independently associated with higher 90-day postoperative mortality, likely reflecting a failure to rescue of these patients following esophagectomy, despite similar composite anastomotic leaks and major complication rates to HIC. These findings warrant further research, to identify potential issues and solutions to improve global outcomes following esophagectomy for cancer. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Published: 2021

15. Postoperative outcomes in oesophagectomy with trainee involvement

Author: Evans, R. P. T. Hodson, J. Kamarajah, S. K. Griffiths, E. A. and Singh, P. Alderson, D. Bundred, J. Gossage, J. and Jefferies, B. McKay, S. Mohamed, I Nepogodiev, D. and Siaw-Acheampong, K. van Hillegersberg, R. Vohra, R. and Wanigasooriya, K. Whitehouse, T. Gjata, A. Moreno, I, J. and Takeda, F. R. Kidane, B. Castro, R. Guevara Harustiak, T. and Bekele, A. Kechagias, A. Gockel, I Kennedy, A. Da Roit, A. Bagajevas, A. Azagra, J. S. Mahendran, H. A. and Mejia-Fernandez, L. Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. Sampaio, A. S. Negoi, I Blanco, R. and Wallner, B. Schneider, P. M. Hsu, P. K. Isik, A. and Gananadha, S. Wills, V Devadas, M. Duong, C. Talbot, M. and Hii, M. W. Jacobs, R. Andreollo, N. A. Johnston, B. and Darling, G. Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. Gaedcke, J. Reim, D. Izbicki, J. and Egberts, J. H. Dikinis, S. Kjaer, D. W. Larsen, M. H. and Achiam, M. P. Saarnio, J. Theodorou, D. Liakakos, T. and Korkolis, D. P. Robb, W. B. Collins, C. Murphy, T. and Reynolds, J. Tonini, V Migliore, M. Bonavina, L. and Valmasoni, M. Bardini, R. Weindelmayer, J. Terashima, M. and White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. and Medina-Franco, H. Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. Beban, G. Babor, R. Gordon, A. and Rossaak, I, J. Pal, I, K. M. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. So, J. B. Y. Gacvski, G. Loureiro, C. Pera, M. Bianchi, A. and Gijon, M. Moreno Fernandez, J. Martin Carrera, M. S. Trugeda and Vallve-Bernal, M. Pascual, M. A. Citores Elmahi, S. and Halldestam, I Hedberg, J. Monig, S. Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, T. B. Colak, E. Sevinc, B. and Hindmarsh, A. Khan, I Khoo, D. Byrom, R. Gokhale, J. and Wilkerson, P. Jain, P. Chan, D. Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. Higgs, S. Nijjar, R. and Viswanath, Y. K. S. Turner, P. Dexter, S. Boddy, A. and Allum, W. H. Oglesby, S. Cheong, E. Beardsmore, D. and Maynard, N. Berrisford, R. Mercer, S. Puig, S. Melhado, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. and Al-Bahrani, A. Bryce, G. Thomas, M. Arndt, A. T. and Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. and Mosse, C. Salim, J. Cheah, S. Wright, T. Cerdeira, M. P. and McQuillan, P. Richardson, M. Liem, H. Spillane, J. and Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. and Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. and Bassari, R. Bui, H. Cecconello, I Sallum, R. A. A. and da Rocha, J. R. M. Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. S. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. and Shea, P. Yeung, J. Allison, F. Carroll, P. and Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. and Beltran-Garcia, T. C. Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. Cortes, N. Cetares, C. Caceres, S. and Duarte, S. Pazdro, A. Snajdauf, M. Faltova, H. and Sevcikova, M. Mortensen, P. B. Katballe, N. Ingemann, T. and Morten, B. Kruhlikava, I Ainswort, A. P. Stilling, N. M. and Eckardt, J. Holm, J. Thorsteinsson, M. Siemsen, M. and Brandt, B. Nega, B. Teferra, E. Tizazu, A. Kauppila, J. S. Koivukangas, V Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. Golcher, H. Emons, G. Azizian, A. and Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. Boecher, U. Reeh, M. Triantafyllou, S. and Schizas, D. Michalinos, A. Baili, E. Mpoura, M. and Charalabopoulos, A. Manatakis, D. K. Balalis, D. Bolger, J. and Baban, C. Mastrosimone, A. McAnena, O. Quinn, A. and Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. Donlon, N. Cervellera, M. Vaccari, S. and Bianchini, S. Sartarelli, L. Asti, E. Bernardi, D. and Merigliano, S. Provenzano, L. Scarpa, M. Saadeh, L. and Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. and De Pasqual, C. A. Tsubosa, Y. Niihara, M. Irino, T. and Makuuchi, R. Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. and Mwachiro, E. AlShehab, D. Ahmed, H. A. Shebani, A. O. and Elhadi, A. Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. Yunrong, T. Thanninalai, S. Aik, H. C. and Soon, P. W. Huei, T. J. Basave, H. N. L. and Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. and Cords, C. Jansen, W. A. Martijnse, I Matthijsen, R. and Bouwense, S. Klarenbeek, B. Verstegen, M. van Workum, F. and Ruurda, J. P. van der Veen, A. van den Berg, J. W. Evenett, N. Johnston, P. Patel, R. MacCormick, A. Young, M. and Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. and Khalil, N. Haris, M. Mirza, Z. U. Qudus, S. B. A. and Sarwar, M. Z. Shehzadi, A. Raza, A. Jhanzaib, M. H. and Farmanali, J. Zakir, Z. Shakeel, O. Nasir, I Khattak, S. and Baig, M. Noor, M. A. Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. Bernardes, A. Campos, J. C. Matos, H. and Braga, T. Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. and Ciuce, C. Drasovean, R. Apostu, R. Paitici, S. Racu, A. E. Obleaga, V, C. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V Cordos, I Birla, R. D. Predescu, D. and Hoara, P. A. Tomsa, R. Shneider, V Agasiev, M. Ganjara, I Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarez, L. S. and Campos, V, P. Rendo, A. G. Garcia, S. S. Santos, E. P. G. and Martinez, E. T. Diaz, M. J. Fernandez Alvarez, C. Magadan and Martin, V. Concepcion Lopez, C. Diaz Rodrigo, A. Rosat and Sanchez, L. E. Perez Cuadrado, M. Bailon Carrasco, C. Tinoco and Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. Mickael, C. and Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. and Karahan, O. Damburaci, N. Hardwick, R. Safranek, P. and Sujendran, V Bennett, J. Afzal, Z. Shrotri, M. Chan, B. and Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. and Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. and Harris, A. Dobson, G. Davies, N. Wilson, I Mayo, D. and Bennett, D. Young, R. Manby, P. Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V Elshaer, A. Cowen, M. Menon, V Tan, L. C. McLaughlin, E. Koshy, R. and Sharp, C. Brewer, H. Das, N. Cox, M. Al Khyatt, W. and Worku, D. Iqbal, R. Walls, L. McGregor, R. Fullarton, G. and Macdonald, A. MacKay, C. Craig, C. Dwerryhouse, S. and Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. and Kelly, M. Davies, A. Di Maggio, F. Mistry, P. Singhal, R. Tucker, O. Kapoulas, S. Powell-Brett, S. Davis, P. and Bromley, G. Watson, L. Verma, R. Ward, J. Shetty, V and Ball, C. Pursnani, K. Sarela, A. Ling, H. Sue Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. and Supramaniam, K. Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. and Moussa, O. Kordzadeh, A. Patil, P. Noaman, I Willem, J. Bouras, G. Evans, R. Singh, M. Warrilow, H. and Ahmad, A. Tewari, N. Yanni, F. Couch, J. Theophilidou, E. Reilly, J. J. van Boxel, G. Akbari, K. Zanotti, D. and Sgromo, B. Sanders, G. Wheatley, T. Ariyarathenam, A. and Reece-Smith, A. Humphreys, L. Choh, C. Carter, N. and Knight, B. Pucher, P. Athanasiou, A. Tan, B. and Abdulrahman, M. Vickers, J. Akhtar, K. Chaparala, R. and Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. and Tamhankar, A. Wyman, A. Walker, R. Grace, B. Abbassi, N. and Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. and Escofet, X. Powell, A. Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. Ben-Younes, H. McCormack, K. Makey, I. A. Karush, M. K. Seder, C. W. Liptay, M. J. and Chmielewski, G. Rosato, E. L. Berger, A. C. Zheng, R. and Okolo, E. Singh, A. Scott, C. D. Weyant, M. J. Mitchell, J. D. West Midlands Res Collaborative
Abstract: Background The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusion Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on perioperative outcomes in the international multicentre Oesophago-Gastric Anastomosis Audit (OGAA). Analysis of 2232 oesophagectomies has shown that trainee involvement did not negatively impact perioperative outcomes.
Published: 2021

16. GAIA GALAXY SURVEY: A MULTI-COLOUR GALAXY SURVEY WITH GAIA

Author: M. Vaccari
Published: 2020
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17. Identification of Single Spectral Lines in Large Spectroscopic Surveys Using UMLAUT: an Unsupervised Machine-learning Algorithm Based on Unbiased Topology

Author: I. Baronchelli, C. M. Scarlata, L. Rodríguez-Muñoz, M. Bonato, L. Morselli, M. Vaccari, R. Carraro, L. Barrufet, A. Henry, V. Mehta, G. Rodighiero, A. Baruffolo, M. Bagley, A. Battisti, J. Colbert, Y. S. Dai, M. De Pascale, H. Dickinson, M. Malkan, C. Mancini, M. Rafelski, and H. I. Teplitz
Subjects: Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: The identification of an emission line is unambiguous when multiple spectral features are clearly visible in the same spectrum. However, in many cases, only one line is detected, making it difficult to correctly determine the redshift. We developed a freely available unsupervised machine-learning algorithm based on unbiased topology (UMLAUT) that can be used in a very wide variety of contexts, including the identification of single emission lines. To this purpose, the algorithm combines different sources of information, such as the apparent magnitude, size and color of the emitting source, and the equivalent width and wavelength of the detected line. In each specific case, the algorithm automatically identifies the most relevant ones (i.e., those able to minimize the dispersion associated with the output parameter). The outputs can be easily integrated into different algorithms, allowing us to combine supervised and unsupervised techniques and increasing the overall accuracy. We tested our software on WISP (WFC3 IR Spectroscopic Parallel) survey data. WISP represents one of the closest existing analogs to the near-IR spectroscopic surveys that are going to be performed by the future Euclid and Roman missions. These missions will investigate the large-scale structure of the universe by surveying a large portion of the extragalactic sky in near-IR slitless spectroscopy, detecting a relevant fraction of single emission lines. In our tests, UMLAUT correctly identifies real lines in 83.2% of the cases. The accuracy is slightly higher (84.4%) when combining our unsupervised approach with a supervised approach we previously developed.
Published: 2021
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18. Linearity of Client/Server Systems.

Author: G. Degli Antoni, D. Cabianca, M. Vaccari, Marco Benini, and F. Casablanca
Published: 1995

19. Exposure to atmospheric aerosols and Preterm births

Author: A, Ranzi, primary, M, Mascolo, additional, C, Zanzi, additional, L, Vaccari, additional, F, Rotondo, additional, M, Vaccari, additional, P, Angelini, additional, M, Jacobs, additional, M, Ottone, additional, and A, Colacci, additional
Published: 2019
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20. Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing

Author: Rachel Nusbaum, Megan L. Marshall, Lauren Yackowski, Lisa R. Susswein, Scott M. Weissman, Kristen J. Vogel Postula, Patricia D. Murphy, Gabi Richard, Jeffrey Bissonnette, Erica M. Vaccari, Wendy K. Chung, Daniel E. Pineda-Alvarez, Jessica K. Booker, Sherri J. Bale, M. Laura Cremona, Rachel T. Klein, Guido D. Pollevick, Zhixiong Xu, Kathleen S. Hruska, and Federica Gibellini
Subjects: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Colorectal cancer, MLH1, hereditary breast and ovarian cancer, hereditary cancer panels, 03 medical and health sciences, 0302 clinical medicine, BRCA1/2, Neoplasms, Internal medicine, Prevalence, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Original Research Article, Stomach cancer, Germ-Line Mutation, Genetics (clinical), Aged, Genetic testing, next generation sequencing, medicine.diagnostic_test, Genetic heterogeneity, business.industry, High-Throughput Nucleotide Sequencing, Cancer, Sequence Analysis, DNA, Middle Aged, medicine.disease, Penetrance, Lynch syndrome, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, Erratum, business
Abstract: Purpose: Germ-line testing for panels of cancer genes using next-generation sequencing is becoming more common in clinical care. We report our experience as a clinical laboratory testing both well-established, high-risk cancer genes (e.g., BRCA1/2, MLH1, MSH2) as well as more recently identified cancer genes (e.g., PALB2, BRIP1), many of which have increased but less well-defined penetrance. Genet Med 18 8, 823–832. Methods: Clinical genetic testing was performed on over 10,000 consecutive cases referred for evaluation of germ-line cancer genes, and results were analyzed for frequency of pathogenic or likely pathogenic variants, and were stratified by testing panel, gene, and clinical history. Genet Med 18 8, 823–832. Results: Overall, a molecular diagnosis was made in 9.0% of patients tested, with the highest yield in the Lynch syndrome/colorectal cancer panel. In patients with breast, ovarian, or colon/stomach cancer, positive yields were 9.7, 13.4, and 14.8%, respectively. Approximately half of the pathogenic variants identified in patients with breast or ovarian cancer were in genes other than BRCA1/2. Genet Med 18 8, 823–832. Conclusion: The high frequency of positive results in a wide range of cancer genes, including those of high penetrance and with clinical care guidelines, underscores both the genetic heterogeneity of hereditary cancer and the usefulness of multigene panels over genetic tests of one or two genes. Genet Med 18 8, 823–832.
Published: 2015

21. Abstract P4-12-01: Characterizing the clinical presentation of individuals with pathogenic variants in a breast/ovarian cancer gene panel

Author: Jessica K. Booker, Lauren Yackowski, Erica M. Vaccari, Maria L Cremona, Melanie Hussong, Kathleen S. Hruska, and Patricia D. Murphy
Subjects: Oncology, Cancer Research, medicine.medical_specialty, education.field_of_study, endocrine system diseases, business.industry, Genetic counseling, PALB2, Population, Cancer, medicine.disease, MSH6, Breast cancer, Internal medicine, Immunology, medicine, skin and connective tissue diseases, Ovarian cancer, business, education, CHEK2
Abstract: Background: Hereditary breast and ovarian cancer (HBOC) is a common indication for referral to cancer genetic counselors. Next generation sequencing panels allow for the efficient evaluation of many genes associated with increased risk of these cancers. The purpose of this study is to compare clinical histories of those with pathogenic variants in high risk versus low/moderate risk genes in order to determine which patients might benefit from more extensive testing by a panel approach. Methods: We queried the results of patients tested at GeneDx for a panel of 21 genes causing increased breast and/or ovarian cancer risk. Data regarding personal and family history of cancer provided on the test requisition forms were analyzed and classified according NCCN guidelines for testing criteria for HBOC syndrome. Results: Of 1709 individuals referred for testing, 146 (8.5%) tested positive for a pathogenic variant. Of these, 33% percent were found to carry a pathogenic BRCA1/2 variant while 67% tested positive for a pathogenic variant in a gene other than BRCA1/2 (CHEK2: 17%; ATM: 12%; PALB2: 10%; BRIP1: 7%; BARD1: 3%; PTEN: 3%; each of FANCC, MSH2, MSH6, NBN, PMS2, RAD51C, RAD51D: 2%; MLH1: 1%). Eighty-six percent of these individuals were affected with cancer. In the probands with a pathogenic BRCA1/2 variant, 66% were diagnosed with breast cancer and 22% with ovarian cancer compared to the probands with a pathogenic variant in a gene other than BRCA1/2 of whom 84% had a history of breast cancer and 17% had ovarian cancer. The highest number of breast cancer diagnoses were found, in decreasing order, in association with pathogenic variants in BRCA1 (20), CHEK2 (20), ATM (17), PALB2 (14), BRCA2 (13), and BRIP1 (12). The greatest number of ovarian cancers were identified, in decreasing order, in association with pathogenic variants in BRCA2 (8), BRCA1 (3), CHEK2 (3), and ATM (3). Furthermore, all of the individuals with pathogenic variants met NCCN guidelines for HBOC. Conclusion: A high yield of pathogenic variants were found in genes other than BRCA1/2. Data analysis also shows that individuals with a pathogenic variant in genes other than BRCA1/2 did not have a notably less severe clinical history than those pathogenic variants in BRCA1/2. As all individuals tested meet NCCN guidelines for HBOC testing, panel testing should be considered in this population. Citation Format: Erica Vaccari, Lauren Yackowski, Melanie Hussong, Patricia Murphy, Maria L Cremona, Jessica Booker, Kathleen Hruska. Characterizing the clinical presentation of individuals with pathogenic variants in a breast/ovarian cancer gene panel [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-12-01.
Published: 2015
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22. Testing methods and equipment for palletized products

Author: M Vaccari, A Greco, F V De Camargo, and A Renzini
Subjects: World Wide Web, Thesaurus (information retrieval), Engineering, business.industry, business
Abstract: The ability to present cutting-edge solutions for packaging in the field of palletized products has to be considered as the result of the investments in research infrastructures and advances in applied researches. In the present article, main equipment and all the other testing facilities used to optimize palletized product are detailed. Tests are implemented in accordance with standard and no standard procedures up to fully innovative methods. This approach is able to provide advice both on the most appropriate palletizing scheme to pack the load, either on the best packaging methods able to conserve intact the product to the consumer. For customer it represents a great added value that allows to experience first-hand palletizing solutions, packaging and stability of the load, reducing production costs and optimizing efficiency.
Published: 2019
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23. The first release of data from the Herschel ATLAS: the SPIRE images★

Author: E. Pascale, R. Auld, A. Dariush, L. Dunne, S. Eales, S. Maddox, P. Panuzzo, M. Pohlen, D. J. B. Smith, S. Buttiglione, A. Cava, D. L. Clements, A. Cooray, S. Dye, G. de Zotti, J. Fritz, R. Hopwood, E. Ibar, R. J. Ivison, M. J. Jarvis, L. Leeuw, M. López-Caniego, E. Rigby, G. Rodighiero, D. Scott, M. W. L. Smith, P. Temi, M. Vaccari, and I. Valtchanov
Subjects: Terahertz radiation, Computer science, media_common.quotation_subject, Bolometer, Astronomy and Astrophysics, Photometer, Space observatory, law.invention, Photometry (optics), Telescope, Spire, Space and Planetary Science, Sky, law, media_common, Remote sensing
Abstract: We have reduced the data taken with the Spectral and Photometric Imaging Receiver (SPIRE) photometer on board the Herschel Space Observatory in the Science Demonstration Phase (SDP) of the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS). We describe the data reduction, which poses specific challenges, both because of the sheer size of the data, and because only two scans are made for each region. We implement effective solutions to process the bolometric timelines into maps, and show that correlations among detectors are negligible, and that the photometer is stable on time scales up to 250 s. This is longer than the time the telescope takes to cross the observed sky region, and it allows us to use naive binning methods for an optimal reconstruction of the sky emission. The maps have equal contribution of confusion and white instrumental noise, and the latter is estimated to 5.3, 6.4, and 6.7 mJy/beam (1-{\sigma}), at 250, 350, and 500 \mu{m}, respectively. This pipeline is used to reduce other H-ATLAS observations, as they became available, and we discuss how it can be used with the optimal map maker implemented in the Herschel Interactive Processing Environment (HIPE), to improve computational efficiency and stability. The SDP dataset is available from this http URL
Published: 2011
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24. HerMES: Herschel-SPIRE observations of Lyman break galaxies

Author: D. Rigopoulou, G. Magdis, R. J. Ivison, A. Amblard, V. Arumugam, H. Aussel, A. Blain, J. Bock, A. Boselli, V. Buat, D. Burgarella, N. Castro-Rodríguez, A. Cava, P. Chanial, D. L. Clements, A. Conley, L. Conversi, A. Cooray, C. D. Dowell, E. Dwek, S. Eales, D. Elbaz, D. Farrah, A. Franceschini, J. Glenn, M. Griffin, M. Halpern, E. Hatziminaoglou, J.-S. Huang, E. Ibar, K. Isaak, G. Lagache, L. Levenson, N. Lu, S. Madden, B. Maffei, G. Mainetti, L. Marchetti, H. T. Nguyen, B. O’Halloran, S. J. Oliver, A. Omont, M. J. Page, P. Panuzzo, A. Papageorgiou, C. P. Pearson, I. Pérez-Fournon, M. Pohlen, D. Rizzo, I. G. Roseboom, M. Rowan-Robinson, B. Schulz, Douglas Scott, N. Seymour, D. L. Shupe, A. J. Smith, J. A. Stevens, M. Symeonidis, M. Trichas, K. E. Tugwell, M. Vaccari, I. Valtchanov, L. Vigroux, L. Wang, G. Wright, C. K. Xu, and M. Zemcov
Subjects: Physics, Sample selection, 010308 nuclear & particles physics, Infrared, Spectral density, Flux, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Galaxy, Wavelength, Spire, Space and Planetary Science, 0103 physical sciences, 010303 astronomy & astrophysics
Abstract: We present first results of a study of the submillimetre (rest frame far-infrared) properties of z~3 Lyman Break Galaxies (LBGs) and their lower-redshift counterparts BX/BM galaxies, based on Herschel-SPIRE observations of the Northern field of the Great Observatories Origins Deep Survey (GOODS-N). We use stacking analysis to determine the properties of LBGs well below the current limit of the survey. Although LBGs are not detected individually, stacking the infrared luminous LBGs (those detected with Spitzer at 24 microns yields a statistically significant submm detection with mean flux = 5.9+/-1.4 mJy confirming the power of SPIRE in detecting UV-selected high-redshift galaxies at submillimetre wavelengths. In comparison, the Spitzer 24 microns detected BX/BM galaxies appear fainter with a stacked value of = 2.7 +/-0.8 mJy. By fitting the Spectral Energy Distributions (SEDs) we derive median infrared luminosities, L_{IR}, of 2.8x10^{12} Lsun and 1.5x10^{11} Lsun for z~3 LBGs and BX/BMs, respectively. We find that $L_{IR} estimates derived from present measurements are in good agreement with those based on UV data for z~2 BX/BM galaxies, unlike the case for z~3 infrared luminous LBGs where the UV underestimates the true $L_{IR}. Although sample selection effects may influence this result we suggest that differences in physical properties (such as morphologies, dust distribution and extent of star-forming regions) between z ~3 LBGs and z~2 BX/BMs may also play a significant role.
Published: 2010
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25. Cold dust and young starbursts: spectral energy distributions of Herschel SPIRE sources from the HerMES survey★

Author: M. Rowan-Robinson, I. G. Roseboom, M. Vaccari, A. Amblard, V. Arumugam, R. Auld, H. Aussel, T. Babbedge, A. Blain, J. Bock, A. Boselli, D. Brisbin, V. Buat, D. Burgarella, N. Castro-Rodriguez, A. Cava, P. Chanial, D. L. Clements, A. Conley, L. Conversi, A. Cooray, C. D. Dowell, E. Dwek, S. Dye, S. Eales, D. Elbaz, D. Farrah, M. Fox, A. Franceschini, W. Gear, J. Glenn, E. A. González Solares, M. Griffin, M. Halpern, E. Hatziminaoglou, J. Huang, E. Ibar, K. Isaak, R. J. Ivison, G. Lagache, L. Levenson, N. Lu, S. Madden, B. Maffei, G. Mainetti, L. Marchetti, A. M. J. Mortier, H. T. Nguyen, B. O'Halloran, S. J. Oliver, A. Omont, M. J. Page, P. Panuzzo, A. Papageorgiou, H. Patel, C. P. Pearson, I. Perez Fournon, M. Pohlen, J. I. Rawlings, G. Raymond, D. Rigopoulou, D. Rizzo, B. Schulz, Douglas Scott, N. Seymour, D. L. Shupe, A. J. Smith, J. A. Stevens, M. Symeonidis, M. Trichas, K. E. Tugwell, I. Valtchanov, L. Vigroux, L. Wang, R. Ward, G. Wright, C. K. Xu, and M. Zemcov
Subjects: Physics, 010308 nuclear & particles physics, Spectral density, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Galaxy, Spire, Space and Planetary Science, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Cirrus, Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Optical depth
Abstract: We present spectral energy distributions (SEDs) for 68 Herschel sources detected at 5-sigma at 250, 350 and 500 mu in the HerMES SWIRE-Lockman field. We explore whether existing models for starbursts, quiescent star-forming galaxies and for AGN dust tori are able to model the full range of SEDs measured with Herschel. We find that while many galaxies (~ 56 %) are well fitted with the templates used to fit IRAS, ISO and Spitzer sources, for about half the galaxies two new templates are required: quiescent ('cirrus') models with colder (10-20 K) dust, and a young starburst model with higher optical depth than Arp 220. Predictions of submillimetre fluxes based on model fits to 4.5-24 mu data agree rather poorly with the observed fluxes, but the agreement is better for fits to 4.5-70 mu data. Herschel galaxies detected at 500 mu tend to be those with the very highest dust masses.
Published: 2010
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26. The SCUBA Half Degree Extragalactic Survey (SHADES) – IX. The environment, mass and redshift dependence of star formation

Author: S. Serjeant, S. Dye, A. Mortier, J. Peacock, E. Egami, M. Cirasuolo, G. Rieke, C. Borys, S. Chapman, D. Clements, K. Coppin, J. Dunlop, S. Eales, D. Farrah, M. Halpern, P. Mauskopf, A. Pope, M. Rowan-Robinson, D. Scott, I. Smail, and M. Vaccari
Subjects: Physics, Initial mass function, 010504 meteorology & atmospheric sciences, Star formation, Astrophysics (astro-ph), FOS: Physical sciences, Flux, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Galaxy, Redshift, Wavelength, Extragalactic background light, Spitzer Space Telescope, Space and Planetary Science, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, QB, 0105 earth and related environmental sciences
Abstract: We present a comparison between the SCUBA Half Degree Extragalactic Survey (SHADES) at 450 and 850 microns in the Lockman Hole East with a deep Spitzer Space Telescope survey at 3.6-24 microns conducted in Guaranteed Time. Using stacking analyses we demonstrate a striking correspondence between the galaxies contributing the submm extragalactic background light, with those likely to dominate the backgrounds at Spitzer wavelengths. Using a combination BRIzK plus Spitzer photometric redshifts, we show that at least a third of the Spitzer-identified submm galaxies at 1 and specific star formation rates are in striking disagreement with some semi-analytic predictions from the Millenium simulation. The discrepancy could either be resolved with a top-heavy initial mass function, or a significant component of the submm flux heated by the interstellar radiation field., Comment: Accepted by MNRAS. SMG environments analysis extended. 17 pages, 18 figures. Includes BoxedEPS
Published: 2008
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27. SUDARE at the VST

Author: M. T. Botticella, E. Cappellaro, G. Pignata, A. Baruffolo, S. Benetti, F. Bufano, E. Cascone, M. . Valle, A. Grado, L. Greggio, L. Limatola, A. Pastorello, L. Tomasella, M. Turatto, M. Vaccari, CAPACCIOLI, MASSIMO, COVONE, GIOVANNI, PAOLILLO, MAURIZIO, M. T., Botticella, E., Cappellaro, G., Pignata, A., Baruffolo, S., Benetti, F., Bufano, Capaccioli, Massimo, E., Cascone, Covone, Giovanni, Valle, M., A., Grado, L., Greggio, L., Limatola, Paolillo, Maurizio, A., Pastorello, L., Tomasella, M., Turatto, and M., Vaccari
Abstract: The SUpernova Diversity And Rate Evolution (SUDARE) programme on the VLT Survey Telescope aims to collect an unbiased and homogeneous sample of supernovae (SNe) in all types of gal- axies out to redshift ~ 0.6. In four years, around 500 Type i a and core-collapse SNe are expected to be discovered, including significant numbers of rare SN types. The programme is outlined and 100 SNe candidates have already been detected in the first year of the pro- gramme. Follow-up spectroscopy of the SN candidates, an important aspect of the programme, is also described.
Published: 2013

28. Selective hydrogenation of HMF to BHMF via Shvo catalyst: mechanistic investigation and DFT calculation

Author: ALBONETTI, STEFANIA, PASINI, THOMAS, SOLINAS, GAVINO, ZANOTTI, VALERIO, CAVANI, FABRIZIO, VACCARI, ANGELO, MAZZANTI, ANDREA, RANIERI, SILVIA, MAZZONI, RITA, M. Vaccari, S. Albonetti, T. Pasini, M. Vaccari, G. Solina, V. Zanotti, F. Cavani, A. Vaccari, A. Mazzanti, S. Ranieri, and R. Mazzoni
Subjects: 5-hydroxymethylfurfural, DFT calculation, ruthenium complexe, hydrogenation, homogeneous catalysi
Published: 2013

29. The selective homogeneous hydrogenation of biomass derived 5-hydroxymethylfurfural: the role of Shvo type catalysts

Author: MAZZONI, RITA, ZANOTTI, VALERIO, PASINI, THOMAS, ALBONETTI, STEFANIA, VACCARI, ANGELO, CAVANI, FABRIZIO, M. Vaccari, R. Mazzoni, M. Vaccari, V. Zanotti, T. Pasini, S. Albonetti, A. Vaccari, and F. Cavani
Subjects: 5-hydroxymethylfurfural, Shvo catalyst, homogeneous hydrogenation
Published: 2012

30. Hydroxycyclopentadienyl Ruthenium Hydride Catalyzed Homogeneous Hydrogenation: the Selective Reduction of Biomass Derived 5-Hydroxymethylfurfural

Author: ZANOTTI, VALERIO, MAZZONI, RITA, PASINI, THOMAS, ALBONETTI, STEFANIA, VACCARI, ANGELO, CAVANI, FABRIZIO, M. Vaccari, V.Zanotti, R. Mazzoni, M. Vaccari, T. Pasini, S. Albonetti, A. Vaccari, and F Cavani
Subjects: 5-hydroxymethylfurfural, ruthenium hydride complexe, homogeneous hydrogenation
Published: 2012

31. The exstrophy-epispadias complex: is aesthetic appearance important?

Author: Karine Furtado Meyer, José Carnevale, L.G. Freitas Filho, D.M.S. Martins, and M. Vaccari
Subjects: medicine.medical_specialty, Abdominoplasty, business.industry, Urology, medicine.medical_treatment, Iliac fossa, Uterine prolapse, Epispadias, medicine.disease, Surgery, Bladder exstrophy, Plastic surgery, medicine.anatomical_structure, medicine, business, Sexual function, Penis
Abstract: OBJECTIVE To show the relevance of cosmetic appearance in the adequate treatment of patients with exstrophy-epispadias complex (EEC), and to indicate that surgery by experienced teams can improve the long-term treatment forecast and the patient's body image. PATIENTS AND METHODS From 1978 to 2002, 71 patients diagnosed with EEC were treated in the authors' institution; 24 (aged 2-23 years) were selected to undergo different surgical procedures. The criterion for surgery considered interviews conducted by the psychology team with the parents and children. The plastic surgery and paediatric urology teams carried out the procedures jointly; the follow-up was 0.33-7 years. RESULTS Five female patients and six male had abdominoplasty to treat multiple scars; eight had intermittent catheterization conduits repositioned from the right iliac fossa to the umbilicus. Six female patients had plastic surgery of the external genitalia and three had a broad mobilization of the urogenital sinus. Thirteen male patients had a small penis and had the corpora cavernosa fully mobilized and the penis reconstructed. Five female patients and one male had anterior osteotomy. One patient with no left testis had it replaced and one patient with uterine prolapse had the uterus fixed to the posterior abdominal wall. Six patients had a second procedure, in two because the outcome of the initial operation was poor and in the others to complement the initial treatment. In all but one patient there was an improvement in the objective criteria, e.g. school absences, difficulty in establishing long-lasting social relationships and refusal to participate in sports activities. However, none of the patients would attempt sexual intercourse. CONCLUSIONS Body image, self-esteem, sexuality, sexual function and fertility are deemed crucial by adolescents; in patients with EEC customised surgical procedures can give a satisfactory aesthetic outcome, and be a further reason for adequately following occasional urinary complications and renal function, to avoid loss to follow-up.
Published: 2004
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32. The far-infrared/radio correlation as probed by Herschel

Author: R. J. Ivison, B. Magnelli, E. Ibar, P. Andreani, D. Elbaz, B. Altieri, A. Amblard, V. Arumugam, R. Auld, H. Aussel, T. Babbedge, S. Berta, A. Blain, J. Bock, A. Bongiovanni, A. Boselli, V. Buat, D. Burgarella, N. Castro-Rodríguez, A. Cava, J. Cepa, P. Chanial, A. Cimatti, M. Cirasuolo, D. L. Clements, A. Conley, L. Conversi, A. Cooray, E. Daddi, H. Dominguez, C. D. Dowell, E. Dwek, S. Eales, D. Farrah, N. Förster Schreiber, M. Fox, A. Franceschini, W. Gear, R. Genzel, J. Glenn, M. Griffin, C. Gruppioni, M. Halpern, E. Hatziminaoglou, K. Isaak, G. Lagache, L. Levenson, N. Lu, D. Lutz, S. Madden, B. Maffei, G. Magdis, G. Mainetti, R. Maiolino, L. Marchetti, G. E. Morrison, A. M. J. Mortier, H. T. Nguyen, R. Nordon, B. O'Halloran, S. J. Oliver, A. Omont, F. N. Owen, M. J. Page, P. Panuzzo, A. Papageorgiou, C. P. Pearson, I. Pérez-Fournon, A. M. Pérez García, A. Poglitsch, M. Pohlen, P. Popesso, F. Pozzi, J. I. Rawlings, G. Raymond, D. Rigopoulou, L. Riguccini, D. Rizzo, G. Rodighiero, I. G. Roseboom, M. Rowan-Robinson, A. Saintonge, M. Sanchez Portal, P. Santini, B. Schulz, D. Scott, N. Seymour, L. Shao, D. L. Shupe, A. J. Smith, J. A. Stevens, E. Sturm, M. Symeonidis, L. Tacconi, M. Trichas, K. E. Tugwell, M. Vaccari, I. Valtchanov, J. Vieira, L. Vigroux, L. Wang, R. Ward, G. Wright, C. K. Xu, M. Zemcov, Royal Observatory Edinburgh (ROE), University of Edinburgh, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AUTRES, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), XMM-Newton Science Operations Centre, European Space Agency (ESA), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Astronomy and Astrophysics [Universty of Toronto], University of Toronto, Station de Pathologie Végétale [Angers], Institut National de la Recherche Agronomique (INRA), Laboratoire Colloïdes et Matériaux Divisés (LCMD), Centre National de la Recherche Scientifique (CNRS)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Physics [Berkeley], University of California [Berkeley], University of California-University of California, Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, School of Physics and Astronomy [Cardiff], Cardiff University, Division of Engineering, Colorado School of Mines, Max-Planck-Institut für Extraterrestrische Physik (MPE), Service de Chimie Physique (SCP), Département de Physico-Chimie (DPC), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Institut National Polytechnique de Grenoble (INPG), Laboratoire de photonique et de nanostructures (LPN), Centre National de la Recherche Scientifique (CNRS), Centre de recherches Paul Pascal (CRPP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), National Radio Astronomy Observatory (NRAO), Department of Chemistry and Biochemistry, University of California [Los Angeles] (UCLA), National Institute of Water and Atmospheric Research [Wellington] (NIWA), Laboratoire de Mecanique des Fluides et d'Acoustique (LMFA), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), British Antarctic Survey (BAS), Natural Environment Research Council (NERC), GoLP/Instituto Plasmas e Fusa˜o Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Laboratoire de Mathématiques Raphaël Salem (LMRS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS), CEA-Direction de l'Energie Nucléaire (CEA-DEN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction de l'Energie Nucléaire (CEA-DEN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Agence Spatiale Européenne = European Space Agency (ESA), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), R. J. Ivison, B. Magnelli, E. Ibar, P. Andreani, D. Elbaz, B. Altieri, A. Amblard, V. Arumugam, R. Auld, H. Aussel, T. Babbedge, S. Berta, A. Blain, J. Bock, A. Bongiovanni, A. Boselli, V. Buat, D. Burgarella, N. Castro, A. Cava, J. Cepa, P. Chanial, A. Cimatti, M. Cirasuolo, D. L. Clement, A. Conley, L. Conversi, A. Cooray, E. Daddi, H. Dominguez, C. D. Dowell, E. Dwek, S. Eale, D. Farrah, M. Fox, A. Franceschini, W. Gear, R. Genzel, J. Glenn, M. Griffin, C. Gruppioni, M. Halpern, E. Hatziminaoglou, K. Isaak, G. Lagache, L. Levenson, N. Lu, D. Lutz, S. Madden, B. Maffei, G. Magdi, G. Mainetti, R. Maiolino, L. Marchetti, G. E. Morrison, A. M. J. Mortier, H. T. Nguyen, R. Nordon, B. O'Halloran, S. J. Oliver, A. Omont, F. N. Owen, M. J. Page, P. Panuzzo, A. Papageorgiou, C. P. Pearson, A., A. Poglitsch, M. Pohlen, P. Popesso, F. Pozzi, J. I. Rawling, G. Raymond, D. Rigopoulou, L. Riguccini, D. Rizzo, G. Rodighiero, I. G. Roseboom, M. Rowan-Robinson, A. Saintonge, M. Sanchez Portal, P. Santini, B. Schulz, Douglas Scott, N. Seymour, L. Shao, D. L. Shupe, A. J. Smith, J. A. Steven, E. Sturm, M. Symeonidi, L. Tacconi, M. Tricha, K. E. Tugwell, M. Vaccari, I. Valtchanov, J. Vieira, L. Vigroux, L. Wang, R. Ward, G. Wright, C. K. Xu, and M. Zemcov
Subjects: Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), 010308 nuclear & particles physics, Flux, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Redshift, Galaxy, Luminosity, Wavelength, Spire, [PHYS.ASTR.GA]Physics [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Far infrared, Space and Planetary Science, 0103 physical sciences, Galaxy formation and evolution, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], 010303 astronomy & astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We set out to determine the ratio, q(IR), of rest-frame 8-1000um flux, S(IR), to monochromatic radio flux, S(1.4GHz), for galaxies selected at far-IR and radio wavelengths, to search for signs that the ratio evolves with redshift, luminosity or dust temperature, and to identify any far-IR-bright outliers - useful laboratories for exploring why the far-IR/radio correlation is generally so tight when the prevailing theory suggests variations are almost inevitable. We use flux-limited 250-um and 1.4-GHz samples, obtained in GOODS-N using Herschel (HerMES; PEP) and the VLA. We determine bolometric IR output using ten bands spanning 24-1250um, exploiting data from PACS and SPIRE, as well as Spitzer, SCUBA, AzTEC and MAMBO. We also explore the properties of an L(IR)-matched sample, designed to reveal evolution of q(IR) with z, spanning log L(IR) = 11-12 L(sun) and z=0-2, by stacking into the radio and far-IR images. For 1.4-GHz-selected galaxies, we see tentative evidence of a break in the flux ratio, q(IR), at L(1.4GHz) ~ 10^22.7 W/Hz, where AGN are starting to dominate the radio power density, and of weaker correlations with z and T(d). From our 250-um-selected sample we identify a small number of far-IR-bright outliers, and see trends of q(IR) with L(1.4GHz), L(IR), T(d) and z, noting that some of these are inter-related. For our L(IR)-matched sample, there is no evidence that q(IR) changes significantly as we move back into the epoch of galaxy formation: we find q(IR) goes as (1+z)^gamma, where gamma = -0.04 +/- 0.03 at z=0-2; however, discounting the least reliable data at z1., A&A Herschel Special Issue, in press as a Letter. 5 pages
Published: 2010
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33. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

Author: Goodson, W.H., III Lowe, L. Carpenter, D.O. Gilbertson, M. Ali, A.M. de Cerain Salsamendi, A.L. Lasfar, A. Carnero, A. Azqueta, A. Amedei, A. Charles, A.K. Collins, A.R. Ward, A. Salzberg, A.C. Colacci, A. Olsen, A.-K. Berg, A. Barclay, B.J. Zhou, B.P. Blanco-Aparicio, C. Baglole, C.J. Dong, C. Mondello, C. Hsu, C.-W. Naus, C.C. Yedjou, C. Curran, C.S. Laird, D.W. Koch, D.C. Carlin, D.J. Felsher, D.W. Roy, D. Brown, D.G. Ratovitski, E. Ryan, E.P. Corsini, E. Rojas, E. Moon, E.-Y. Laconi, E. Marongiu, F. Al-Mulla, F. Chiaradonna, F. Darroudi, F. Martin, F.L. Van Schooten, F.J. Goldberg, G.S. Wagemaker, G. Nangami, G. Calaf, G.M. Williams, G. Wolf, G.T. Koppen, G. Brunborg, G. Kim Lyerly, H. Krishnan, H. Hamid, H.A. Yasaei, H. Sone, H. Kondoh, H. Salem, H.K. Hsu, H.-Y. Park, H.H. Koturbash, I. Miousse, I.R. Ivana Scovassi, A. Klaunig, J.E. Vondráček, J. Raju, J. Roman, J. Wise, J.P., Sr. Whitfield, J.R. Woodrick, J. Christopher, J.A. Ochieng, J. Martinez-Leal, J.F. Weisz, J. Kravchenko, J. Sun, J. Prudhomme, K.R. Narayanan, K.B. Cohen-Solal, K.A. Moorwood, K. Gonzalez, L. Soucek, L. Jian, L. D'Abronzo, L.S. Lin, L.-T. Li, L. Gulliver, L. McCawley, L.J. Memeo, L. Vermeulen, L. Leyns, L. Zhang, L. Valverde, M. Khatami, M. Romano, M.F. Chapellier, M. Williams, M.A. Wade, M. Manjili, M.H. Lleonart, M. Xia, M. Gonzalez, M.J. Karamouzis, M.V. Kirsch-Volders, M. Vaccari, M. Kuemmerle, N.B. Singh, N. Cruickshanks, N. Kleinstreuer, N. Van Larebeke, N. Ahmed, N. Ogunkua, O. Krishnakumar, P.K. Vadgama, P. Marignani, P.A. Ghosh, P.M. Ostrosky-Wegman, P. Thompson, P. Dent, P. Heneberg, P. Darbre, P. Leung, P.S. Nangia-Makker, P. Cheng, Q.S. Brooks Robey, R. Al-Temaimi, R. Roy, R. Andrade-Vieira, R. Sinha, R.K. Mehta, R. Vento, R. Di Fiore, R. Ponce-Cusi, R. Dornetshuber-Fleiss, R. Nahta, R. Castellino, R.C. Palorini, R. Hamid, R.A. Langie, S.A.S. Eltom, S. Brooks, S.A. Ryeom, S. Wise, S.S. Bay, S.N. Harris, S.A. Papagerakis, S. Romano, S. Pavanello, S. Eriksson, S. Forte, S. Casey, S.C. Luanpitpong, S. Lee, T.-J. Otsuki, T. Chen, T. Massfelder, T. Sanderson, T. Guarnieri, T. Hultman, T. Dormoy, V. Odero-Marah, V. Sabbisetti, V. Maguer-Satta, V. Kimryn Rathmell, W. Engström, W. Decker, W.K. Bisson, W.H. Rojanasakul, Y. Luqmani, Y. Chen, Z. Hu, Z.
Abstract: Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/ mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology. © The Author 2015.
Published: 2015

34. Risk of low bone density in women attending menopause clinics in Italy

Author: E. Pasinetti, V. Azzini, G. Mandruzzato, N. A. Giulini, D. Mossotto, P. Pesando, U. Bellati, P. A. Todaro, C. Cetera, E. Cirese, S. Garofalo, P. Bellardini, G. Donini, E. Di Gioia, P. D. Rattazzi, Mauro Costa, F. Bertelli, L. Massacesi, G. B. Serra, F. Dolci, S. Garzarelli, L. Falasca, M. Buonerba, F. Tirozzi, P. Amantea, L. Marino, C. Malanetto, D. Salvatores, G. Polizzotti, C. Minervini, M. Fabiani, P. Pupita, E. Bocchin, F. Repetti, G. Cecchini, S. Votano, G. Gentile, C. Donati Sarti, S. Winkler, V. Levi D'Ancona, L. Pacilli, A. Melani, F. Petraglia, M. Penotti, M. Mucci, P. Cristiani, A. Viani, G. Del Frate, A. Lanzone, G. Comitini, P. Tartaglino, Bacchi Modena, M. Massobrio, C. Romanini, V. Marsoni, C. Donadio, C. Gigli, G. Buoso, S. Bennici, R. A. Genazzani, G. Scarselli, B. A. Samaja, V. De Leo, C. Campagnoli, G. Dolfin, G. Cicchetti, V. Zacchi, M. Vaccari, F. Raffaelli, A. Careccia, S. Bottino, P. Ciccarelli, G. Giarre, L. Spagnuolo, R. Fraioli, C. Angeloni, G. Meli, S. Quaranta, E. Esposito, Q. Di Nisio, U. Omodei, P. Di Donato, Francesco Raspagliesi, E. Arisi, C. Santilli, D. De Aloysio, G. Balsotti, M. Gamper, C. Belloni, R. Sposetti, E. Baldaccini, C. M. Bossi, M. Luerti, D. Colombo, G. Zandonini, Fabio Parazzini, P. Curiel, D. Ferrante, and G. Stellin
Subjects: medicine.medical_specialty, Outpatient Clinics, Hospital, Obstetrics, business.industry, Smoking, Obstetrics and Gynecology, Middle Aged, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Menopause, Cross-Sectional Studies, Italy, Bone Density, Risk Factors, Odds Ratio, medicine, Low bone density, Humans, Female, business, Contraceptives, Oral
Abstract: In order to offer data on the epidemiological profile of women with low bone density (LBD), we have considered information collected in the framework of a large cross-sectional study conducted on women around menopause attending a network of first level outpatients menopause clinics in Italy.During 1997 and 2000, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counseling about menopause or treatment of menopausal symptoms. Eligible for the study were women consecutively observed during the study period. Up to March 2000 a total of 42464 women (mean age 53 years) were observed at the 268 participating centers. Bone mass density was measured in 25113 cases, which are considered in this analysis. LBD (i.e. osteopenia or osteoporosis) was defined according to WHO classification.The frequency of LBD increased with age: in comparison with women agedor =51 years, the odds ratio (OR) of LBD was 1.5 and 2.2, respectively, in women aged 52-55 andor =56. No association emerged between LBD and parity: in comparison with nulliparae, the OR of LBD were 1.1 and 1.0, respectively, in women reported 1 or 2 or more full term pregnancies. Smokers were at increased risk of LBD, the corresponding OR being for smokers, in comparison with non smokers, 1.2 (95% confidence interval, CI, 1.1-1.3). In comparison with women in the lower tertile of body mass index, the OR of LBD decreased in subsequent tertiles, being, respectively, 0.9 and 0.7 in the middle and highest tertile. The OR of LBD was 2.2 in postmenopausal women, in comparison with premenopausal ones and the OR decreased increasing age at menopause. Ever OC users were at slightly decreased risk of LBD: in comparison with never OC users, the OR was 0.9 (95% CI 0.8-1.0) in ever OC users.The results of this large study confirm, in a Southern European population, the association of age at menopause and body mass on the risk of LBD, and suggest that ever OC women are at decreased risk of LBD.
Published: 2002
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35. Left Ventricular Remodeling, Systolic Function, and Diastolic Function in Young Adults With β-Thalassemia Intermedia

Author: Giuliano Bosi, Sabrina Scarcia, M. Vaccari, Roberto Crepaz, Walter Pitscheider, Monica Fortini, and M. R. Gamberini
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Ejection fraction, medicine.diagnostic_test, business.industry, Diastole, Stroke volume, Doppler echocardiography, Critical Care and Intensive Care Medicine, medicine.disease, Afterload, Internal medicine, medicine, Cardiology, Systole, Cardiology and Cardiovascular Medicine, Ventricular remodeling, business, Isovolumic relaxation time
Abstract: Background The aim of this study was to investigate the left ventricular (LV) remodeling and function in 24 asymptomatic young adults affected by β-thalassemia intermedia (TI), in order to compare the obtained data with that of 80 patients affected by β-thalassemia major (TM) and 65 healthy subjects. Methods LV volumes and shapes, mass index, mass/volume ratio, systolic and diastolic function, stroke volume, and cardiac index were determined by two-dimensional and M-mode echocardiography. Results In the TM and TI groups, LV volumes, diastolic and systolic shapes were significantly different from the control subjects, but the ejection fraction was slightly reduced only in the TM group. The TI group had larger LV volumes than did the TM group (mean [± SD] end-diastolic volume index, 99.4 ± 21.9 vs 82.7 ± 21.5 mL/m 2 , respectively [p 2 , respectively[p Conclusions Asymptomatic young adults with TI show significant increases in LV volumes, LV mass, and cardiac index that are more pronounced than those in TM patients. LV systolic function is preserved in the TI group but is slightly depressed in the TM group due to the increase of afterload and to reduced contractility. The hemodynamic and hematologic factors involved in the etiopathogenesis of these findings are discussed, such as the treatment strategy.
Published: 2002
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36. Ruolo della Cito-assistenza in corso di Agobiopsia Percutanea Polmonare Tc-guidata

Author: DAVOLI, FABIO, ASADI, NIZAR, STELLA, FRANCO, CASSANELLI, NICOLA, DOLCI, GIAMPIERO, LUCIANO, GIULIA, BINI, ALESSANDRO, M. Vaccari, F. Bassi, F. Davoli, N. Asadi, F. Stella, M. Vaccari, F. Bassi, N. Cassanelli, G. Dolci, G. Luciano, and A. Bini
Subjects: Agobiopsia Percutanea, Polmonare, Cito-assistenza
Published: 2009

37. Risk factors for genital prolapse in non-hysterectomized women around menopause

Author: Francesco Raspagliesi, P. Curiel, D. Ferrante, A. Careccia, D. Salvatores, S. Bottino, G. Stellin, F. Tirozzi, G. Dolfin, P. Ciccarelli, G. Giarre, L. Spagnuolo, P. Pesando, U. Bellati, R. Fraioli, G. Donini, C. Santilli, C. Angeloni, G. Meli, L. Marino, C. Malanetto, G. Zandonini, U. Omodei, V. Levi D'Ancona, G. Polizzotti, P. Di Donato, E. Pasinetti, A. Melani, M. Gamper, F. Repetti, G. Mandruzzato, Fabio Parazzini, C. Minervini, P. Pupita, G. Del Frate, G. Comitini, V. Zacchi, R. Sposetti, Q. Di Nisio, B. Modena, M. Fabiani, S. Garofalo, P. A. Todaro, G. B. Serra, F. Dolci, M. Massobrio, A. Lanzone, P. Bellardini, F. Petraglia, P. D. Rattazzi, E. Di Gioia, Mauro Costa, S. Winkler, G. Cicchetti, F. Bertelli, L. Pacilli, S. Votano, V. Marsoni, F. Raffaelli, C. Campagnoli, D. De Aloysio, V. Azzini, S. Garzarelli, C. Gigli, D. Mossotto, C. Cetera, E. Bocchin, G. Cecchini, C. Donati Sarti, M. Mucci, S. Bennici, E. Baldaccini, A. Viani, C. Donadio, C. M. Bossi, M. Luerti, D. Colombo, C. Romanini, G. Gentile, P. Cristiani, G. Buoso, G. Scarselli, M. Vaccari, M. Penotti, R. A. Genazzani, B. A. Samaja, V. De Leo, P. Tartaglino, E. Cirese, L. Falasca, P. Amantea, M. Buonerba, N. A. Giulini, S. Quaranta, E. Esposito, E. Arisi, G. Balsotti, C. Belloni, and L. Massacesi
Subjects: Menopause, medicine.medical_specialty, Reproductive Medicine, Obstetrics, business.industry, Cross-sectional study, Epidemiology, medicine, Obstetrics and Gynecology, Sex organ, business, medicine.disease
Published: 2000
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38. Determinants of hysterectomy and oophorectomy in women attending menopause clinics in Italy

Author: F. Tirozzi, E. Arisi, L. Marino, C. Malanetto, G. Balsotti, C. Belloni, C. Gigli, L. Massacesi, D. De Aloysio, A. Careccia, S. Bennici, S. Bottino, M. Penotti, C. Minervini, S. Winkler, F. Repetti, G. Dolfin, V. Levi D'Ancona, P. Ciccarelli, U. Bellati, G. Giarre, E. Baldaccini, B. Modena, S. Garzarelli, V. Marsoni, P. Di Donato, A. Lanzone, Francesco Raspagliesi, C. M. Bossi, M. Luerti, D. Colombo, C. Santilli, E. Pasinetti, R. A. Genazzani, G. Zandonini, B. A. Samaja, M. Gamper, F. Raffaelli, V. De Leo, L. Spagnuolo, G. Comitini, R. Sposetti, R. Fraioli, A. Melani, L. Falasca, C. Angeloni, G. Meli, Fabio Parazzini, M. Vaccari, E. Di Gioia, Mauro Costa, F. Petraglia, P. Curiel, D. Ferrante, U. Omodei, P. A. Todaro, N. A. Giulini, G. B. Serra, F. Dolci, G. Donini, S. Garofalo, P. Bellardini, S. Quaranta, G. Cicchetti, P. Tartaglino, G. Stellin, P. Amantea, P. D. Rattazzi, E. Esposito, F. Bertelli, Q. Di Nisio, C. Donadio, V. Zacchi, C. Campagnoli, G. Gentile, E. Cirese, P. Cristiani, G. Mandruzzato, E. Bocchin, S. Votano, G. Cecchini, C. Donati Sarti, G. Polizzotti, M. Mucci, P. Pesando, M. Fabiani, L. Pacilli, M. Buonerba, P. Pupita, V. Azzini, D. Mossotto, C. Cetera, C. Romanini, G. Buoso, G. Scarselli, A. Viani, D. Salvatores, G. Del Frate, and M. Massobrio
Subjects: Adult, medicine.medical_specialty, Cross-sectional study, Ovariectomy, medicine.medical_treatment, Hysterectomy, General Biochemistry, Genetics and Molecular Biology, Bilateral oophorectomy, Body Mass Index, Epidemiology, Odds Ratio, medicine, Humans, Aged, Uterine Diseases, Gynecology, business.industry, Obstetrics and Gynecology, Oophorectomy, Mean age, Middle Aged, medicine.disease, Menopause, Cross-Sectional Studies, Italy, Educational Status, Women's Health, Female, business, Body mass index
Abstract: Objective: To analyse determinants of hysterectomy for benign uterine conditions with or without oophorectomy in Italy, a country with among the lowest rates of hysterectomy worldwide. Methods: Between 1997 and 1999, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms. A total of 25 644 women entered the study. Characteristics of women who underwent and women who did not undergo hysterectomy and oophorectomy were compared. Results: Out of the 25644 women considered, 4727 were hysterectomized (18.4%). Mean age at surgery was 46.8 years. The OR of hysterectomy decreased with increasing educational level: in comparison with women with primary and none education, the OR of hysterectomy was 0.8 (95% CI 0.7-0.9) and 0.6 (95% CI 0.5 0.7) respectively for women with intermediate or high university degree. Body mass index (BMI, kg m -2 ) was related to the frequency of hysterectomy; in comparison with women with BMI ≤ 23.8, the OR of hysterectomy was 1.2 (95% CI 1.1 1.3) and 1.4 (95% CI 1.2-1.5) respectively for women with a BMI 23.8-27.2 and > 27.2. The frequency, of bilateral oophorectomy increased with age at hysterectomy: in comparison with women who have had hysterectomy when aged ≤43 years, the OR of bilateral oophorectomy during hysterectomy was respectively 1.9, 3.4 and 4.3 in women who had hysterectomy at age 44 47, 48 51 and > 52 years. The frequency of bilateral oophorectomy was lower in more educated women: in comparison with women reporting none or primary degree the OR was 1.0 and 0.8 respectively for women with intermediate and high university degree. Conclusions: The results of this analysis indicate that hysterectomy for benign conditions is more frequently performed in less educated women, in nulliparae and in women with higher BMI. During hysterectomy for benign conditions, bilateral oophorectomy is more frequent in less educated women and its frequency increases with women's age.
Published: 2000
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39. Storage-ring FEL amplifiers and electron beam longitudinal mode-damping times

Author: Alberto Renieri, M. Vaccari, Luca Mezi, P.L. Ottaviani, and Giuseppe Dattoli
Subjects: Longitudinal mode, Physics, Optics, business.industry, Amplifier, Cathode ray, business, Storage ring
Published: 1998
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40. HerMES: The Contribution to the Cosmic Infrared Background from Galaxies Selected by Mass and Redshift

Author: M. P. Viero, L. Moncelsi, R. F. Quadri, V. Arumugam, R. J. Assef, M. Béthermin, J. Bock, C. Bridge, C. M. Casey, A. Conley, A. Cooray, D. Farrah, J. Glenn, S. Heinis, E. Ibar, S. Ikarashi, R. J. Ivison, K. Kohno, G. Marsden, S. J. Oliver, I. G. Roseboom, B. Schulz, D. Scott, P. Serra, M. Vaccari, J. D. Vieira, L. Wang, J. Wardlow, G. W. Wilson, M. S. Yun, M. Zemcov, Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Stellar mass, Stacking, FOS: Physical sciences, galaxies [submillimeter], Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Astronomy & Astrophysics, 01 natural sciences, galaxies [infrared], Atomic, Physical Chemistry, Luminosity, Particle and Plasma Physics, Cosmic infrared background, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Nuclear, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, evolution [galaxies], Luminous infrared galaxy, Physics, large-scale structure of universe, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Molecular, Astronomy and Astrophysics, Galaxy, Redshift, observations [cosmology], Space and Planetary Science, astro-ph.CO, Astrophysics::Earth and Planetary Astrophysics, Astronomical and Space Sciences, Astrophysics - Cosmology and Nongalactic Astrophysics, Physical Chemistry (incl. Structural)
Abstract: We quantify the fraction of the cosmic infrared background (CIB) that originates from galaxies identified in the UV/optical/near-infrared by stacking 81,250 (~35.7 arcmin^2) K-selected sources (K_AB < 24.0), split according to their rest-frame U - V vs. V - J colors into 72,216 star-forming and 9,034 quiescent galaxies, on maps from Spitzer/MIPS (24um), Herschel/SPIRE (250, 350, 500um), Herschel/PACS (100, 160um), and AzTEC (1100um). The fraction of the CIB resolved by our catalog is (69 $\pm$ 15)% at 24um, (78 $\pm$ 17)% at 70um, (58 $\pm$ 13)% at 100um, (78 $\pm$ 18)% at 160um, (80 $\pm$ 17)% at 250um, (69 $\pm$ 14)% at 350um, (65 $\pm$ 12)% at 500um, and (45 $\pm$ 8)% at 1100um. Of that total, about 95% originates from star-forming galaxies, while the remaining 5% is from apparently quiescent galaxies. The CIB at $��$ < 200um is sourced predominantly from galaxies at z < 1, while at $��$ > 200um the bulk originates from 1 < z < 2. Galaxies with stellar masses log(M/ M_sun)=9.5-11 are responsible for the majority of the CIB, with those in the log(M/ M_sun)=9.5-10 contributing mostly at $��$ < 250um, and those in the log(M/ M_sun)=10.5-11 bin dominating at $��$ > 350um. The contribution from galaxies in the log(M/ M_sun)=9.0-9.5 and log(M/ M_sun)=11.0-12.0 stellar mass bins contribute the least, both of order 5%, although the highest stellar-mass bin is a significant contributor to the luminosity density at z > 2. The luminosities of the galaxies responsible for the CIB shifts from a combination of "normal" and luminous infrared galaxies (LIRGs) at $��$ < 160um, to LIRGs at 160um < $��$ < 500um, to finally LIRGs and ultra-luminous infrared galaxies (ULIRGs) at $��$ > 500um. Stacking analyses were performed with SIMSTACK (available at http://www.astro.caltech.edu/~viero/viero_homepage/toolbox.html) which accounts for possible biases due to clustering., 24 pages, 12 Figures, and 8 Tables. Accepted for publication in The Astrophysical Journal. Tabulated data and Software available at http://www.astro.caltech.edu/~viero/viero_homepage/toolbox.html
Published: 2013
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41. Glucocorticoids upregulate decreased IL-7 receptor expression in asthmatic patients and simian immunodeficiency virus-infected non-human primates

Author: M, Moniuszko, D, Lipinska, M, Jeznach, K, Kowal, K, Grubczak, M, Rusak, K, McKinnon, M, Vaccari, N P M, Liyanage, C, Fenizia, N, Wawrusiewicz-Kurylonek, M, Dabrowska, E, Jablonska, A, Kretowski, M, Gorska, and A, Bodzenta-Lukaszyk
Subjects: Adult, CD4-Positive T-Lymphocytes, Receptors, Interleukin-7, Interleukin-7, Simian Acquired Immunodeficiency Syndrome, Animals, Humans, Middle Aged, Glucocorticoids, Macaca mulatta, Asthma, Aged
Abstract: Signaling through interleukin-7 receptor (IL-7R) is essential for regulation of T-cell homeostasis and survival. Previously, we and others have found diminished IL-7R levels in simian immunodeficiency virus (SIV) - infected non-human primates and human immunodeficiency virus (HIV) - infected patients. To date, it remains unknown whether changes in IL-7R expression could also be linked to non-infectious inflammatory diseases such as asthma or anti-inflammatory drug use. Here, we investigated through flow cytometry the levels of IL-7R expression on CD4+ and CD4- T-cells in asthmatic patients in relation to disease severity, immune status and glucocorticoid (GC) use. In addition, we sought to evaluate the effects of in vivo and in vitro GC treatment on IL-7R expression in both asthmatic patients and SIV-infected non-human primates. We demonstrated that expression of IL-7R on peripheral blood CD4+ T-cells was significantly decreased in clinically stable GC-naive mild and moderate asthmatic patients. Accordingly, the development of asthmatic reaction following bronchial allergen challenge performed in sensitized subjects was associated with a significant drop in levels of IL-7R on circulating CD4+ T-cells. In contrast, CD4+ T-cells from both, mild and moderate, but not severe asthmatics, treated with inhaled GC displayed levels of IL-7R similar to that seen in healthy controls. We did not find significant differences with serum or sputum interleukin-7 levels among healthy controls and GC-naïve and GC-treated asthmatic patients. Furthermore, both in vitro GC treatment and short-term oral GC administration to asthmatic patients resulted in a significant enhancement of IL-7R. Similarly, we demonstrated that GC-stimulated T-cells from SIV-infected non-human primates up-regulated IL-7R expression. Accordingly, experimental short-term systemic in vivo administration of GC to SIV-infected macaques led to enhancement of IL-7R expression on circulating T-cells. Our data indicate that GC bear potential to recover diminished IL-7R expression, as well in asthma as in lentiviral infection.
Published: 2013

42. Potentiating Effect of Galanin on GHRH-Induced GH Release. Comparison Between Old and Young Subjects

Author: L Lazzaroni, L Cucchi, Luigi Cantalamessa, L. Cremagnani, M Vaccari, A. Orsatti, and E Maronati
Subjects: Adult, Male, endocrine system, medicine.medical_specialty, Somatotropic cell, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Galanin, Growth Hormone-Releasing Hormone, Biochemistry, Endocrinology, Bolus (medicine), Internal medicine, medicine, Humans, Gh release, Young adult, Saline, Aged, business.industry, Biochemistry (medical), Age Factors, Drug Synergism, General Medicine, Plasma gh, Growth hormone secretion, Growth Hormone, Female, business, hormones, hormone substitutes, and hormone antagonists
Abstract: The aim of our study was to investigate the effect of galanin on basal and GHRH-stimulated GH secretion in a healthy group of elderly subjects and in a healthy group of young subjects for comparison. Ten old subjects (mean age 75 +/- 1.15 years) and an equal number of healthy young volunteers (mean age 26 +/- 0.71 years) underwent three stimulation tests in random order. Galanin infusion for 60 minutes (10 micrograms/kg in 100 ml saline) failed to provoke an appreciable release of circulating GH in old subjects, while it induced a significant increase of plasma GH in the young adults; GHRH administration i.v. in bolus (100 micrograms in 1 ml saline) elicited a significant GH response in both groups; however, in the older group GH response was significantly (p < 0.05) lower than in the young adults. The administration of galanin (10 micrograms/kg in 100 ml saline as an i.v. infusion for 60 min) plus GHRH (100 micrograms in 1 ml saline i.v. in bolus), potentiated GH response in old and young subjects. The combined administration of two peptides was able to elicit a clear GH release even in the older subjects who were hyporesponsive/unresponsive to galanin and/or GHRH alone. In the elderly, plasma GH values observed after the combined stimuli overlapped with GH values observed after GHRH alone in the young adults. In conclusion, our study confirms that galanin has a synergic effect with GHRH on GH release both in younger and elderly subjects. Moreover, our data confirm an impaired responsivity to GHRH in the elderly and demonstrate that galanin is able to normalize response of somatotrophs to GHRH in old people.
Published: 1996
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43. Exchange-correlation effects on the electronic stopping power of slow protons in metals

Author: M. Vaccari, A. Ventura, Ventura, A., and Vaccari, M.
Subjects: Physics, Applicazioni di fisica e tecnologie nucleari, General Physics and Astronomy, Stopping power (particle radiation), Local-density approximation, Atomic physics
Abstract: We show in local density approximation the effect of exchange-correlation potentials on the electronic stopping of slow protons in metals, evaluated in the frame of a simple model, whose results are in good agreement with density-functional calculations.
Published: 1996
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44. A Four-Year Follow-Up of Mitral Bioprostheses by Fast Fourier Transform Monitoring of the First Heart Sound

Author: M. Vaccari, Maria Brunazzi Brunazzi, Daniele Cavazzini, Carlo Longhini, Enrico Baracca, P. Sgobino, and Mario Pasqualini
Subjects: Sound (medical instrument), medicine.medical_specialty, medicine.anatomical_structure, business.industry, Mitral valve, Internal medicine, Fast Fourier transform, medicine, Follow up studies, Cardiology, Spectral analysis, General Medicine, business
Published: 1994
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45. Ultra Steep Spectrum Radio Sources in the Lockman Hole: SERVS Identifications and Redshift Distribution at the Faintest Radio Fluxes

Author: L. Bizzocchi, J. Afonso, E. Ibar, M. Grossi, C. Simpson, S. Chapman, M. J. Jarvis, H. Rottgering, R. P. Norris, J. Dunlop, R. J. Ivison, H. Messias, J. Pforr, M. Vaccari, N. Seymour, P. Best, E. Gonz, D. Farrah, J.-S. Huang, M. Lacy, C. Marastron, L. Marchetti, J.-C. Mauduit, S. Oliver, D. Rigopoulou, S. A. Stanford, J. Surace, and G. Zeimann
Published: 2011
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46. A new EXAFS investigation of local structural changes in amorphous and crystalline GeO(2) at high pressure

Author: M. Vaccari, Sakura Pascarelli, Giuliana Aquilanti, and Olivier Mathon
Subjects: Condensed matter physics, Extended X-ray absorption fine structure, Chemistry, Shell (structure), chemistry.chemical_element, Germanium, Condensed Matter Physics, Amorphous solid, Crystallography, Structural change, Absorption edge, Octahedron, Intermediate state, General Materials Science
Abstract: Structural transformations at high pressure in amorphous and quartz-like crystalline GeO(2) have been investigated by using a Paris-Edinburgh press coupled to EXAFS spectroscopy. From both the germanium absorption edge position and the Ge-O distance evolution, new detailed information has been obtained about the pressure behavior of the short range order. Crystalline GeO(2) undergoes a transformation from four- to six-fold coordination at about 8.5 GPa, but at least the whole 6-12 GPa pressure range should be considered as the transition region. On the other hand, amorphous GeO(2) is characterized by a much more gradual structural change and the full octahedral state is not reached at 13 GPa as commonly believed. Furthermore, no support to the recently claimed fully pentahedral intermediate state can be given. EXAFS signals of glassy GeO(2) beyond the first Ge-O shell qualitatively confirm the continuous breakdown of the intermediate range order up to 10 GPa.
Published: 2011

47. Pressure-inducedFe↔Cucationic valence exchange and its structural consequences: High-pressure studies of delafossiteCuFeO2

Author: Sakura Pascarelli, M. Kertzer, Raymond Jeanloz, Manuel Muñoz, Michael Hanfland, Moshe P. Pasternak, Leonid Dubrovinsky, W. M. Xu, G. Kh. Rozenberg, A. Kurnosov, and M. Vaccari
Subjects: Physics, Valence (chemistry), Mössbauer effect, 02 engineering and technology, Crystal structure, engineering.material, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, Delafossite, Crystallography, High pressure, 0103 physical sciences, engineering, Volume reduction, Antiferromagnetism, Structural transition, Atomic physics, 010306 general physics, 0210 nano-technology
Abstract: The present high-pressure studies of ${\text{CuFeO}}_{2}$ to 30 GPa using x-ray diffraction, along with $^{57}\text{F}\text{e}$ M\"ossbauer and Fe and $\text{Cu}\text{ }K$-edge x-ray absorption spectroscopy methods, reveal a sequence of intricate structural/electronic-magnetic pressure-induced transitions. The low-pressure $R\overline{3}m$ structure (0--18 GPa) is composed of sheets of ${\text{Fe}}_{S=5/2}^{3+}$ ions alternating with layers of ${\text{O-Cu}}_{S=0}^{1+}\text{-O}$ dumbbells, the latter oriented along the $c$ axis. This structure is characterized by an unusual positive $d(c/a)/dP$. At 18 GPa a structural transition takes place to a more isotropic $C2/c$ structure with the ${\text{O-Cu}}_{S=0}^{1+}\text{-O}$ axis tilted $28\ifmmode^\circ\else\textdegree\fi{}$ from the $c$ axis and with negative $d(c/a)/dP$. This transition corroborates with the onset of long-range antiferromagnetic order. Starting at $\ensuremath{\sim}23\text{ }\text{GPa}$, with an initial volume reduction in $\ensuremath{\sim}|\ensuremath{\Delta}V/{V}_{0}|=0.16$, the Cu-Fe bands overlap and this leads to a $({\text{Cu}}_{S=0}^{1+}{\text{Fe}}_{S=5/2}^{3+})\ensuremath{\rightarrow}({\text{Cu}}_{S=1/2}^{2+}{\text{Fe}}_{S=2}^{2+})$ interionic valence exchange in about 1/3 of the $C2/c{\text{-CuFeO}}_{2}$ at 27 GPa. As a result: (i) the ${\text{Cu}}^{2+}\text{-O}$ becomes fourfold coordinated and is in a new crystallographic structure with space group $P\overline{3}m$, and (ii) the N\'eel temperature increases above twofold $[{T}_{\text{N}}({\text{Cu}}_{S=1/2}^{2+}{\text{Fe}}_{S=2}^{2+})\ensuremath{\approx}2.2{T}_{\text{N}}({\text{Cu}}_{S=0}^{1+}{\text{Fe}}_{S=5/2}^{3+})]$. This sequence of transitions is reversible with minimal hysteresis.
Published: 2010
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48. Structural changes in amorphousGeS2at high pressure

Author: Michael Hanfland, Sakura Pascarelli, Marie-Vanessa Coulet, Gaston Garbarino, Elissaios Stavrou, M. Vaccari, Giuliana Aquilanti, C. Raptis, and Angela Trapananti
Subjects: Materials science, Optics, business.industry, High pressure, X-ray crystallography, Analytical chemistry, Condensed Matter Physics, business, Electronic, Optical and Magnetic Materials, Amorphous solid
Published: 2010
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49. The Herschel ATLAS

Author: S. Eales, L. Dunne, D. Clements, A. Cooray, G. De Zotti, S. Dye, R. Ivison, M. Jarvis, G. Lagache, S. Maddox, M. Negrello, S. Serjeant, M. A. Thompson, E. Van Kampen, A. Amblard, P. Andreani, M. Baes, A. Beelen, G. J. Bendo, D. Benford, F. Bertoldi, J. Bock, D. Bonfield, A. Boselli, C. Bridge, V. Buat, D. Burgarella, R. Carlberg, A. Cava, P. Chanial, S. Charlot, N. Christopher, P. Coles, L. Cortese, A. Dariush, E. da Cunha, G. Dalton, L. Danese, H. Dannerbauer, S. Driver, J. Dunlop, L. Fan, D. Farrah, D. Frayer, C. Frenk, J. Geach, J. Gardner, H. Gomez, J. González-Nuevo, E. González-Solares, M. Griffin, M. Hardcastle, E. Hatziminaoglou, D. Herranz, D. Hughes, E. Ibar, Woong-Seob Jeong, C. Lacey, A. Lapi, A. Lawrence, M. Lee, L. Leeuw, J. Liske, M. López-Caniego, T. Müller, K. Nandra, P. Panuzzo, A. Papageorgiou, G. Patanchon, J. Peacock, C. Pearson, S. Phillipps, M. Pohlen, C. Popescu, S. Rawlings, E. Rigby, M. Rigopoulou, A. Robotham, G. Rodighiero, A. Sansom, B. Schulz, D. Scott, D. J. B. Smith, B. Sibthorpe, I. Smail, J. Stevens, W. Sutherland, T. Takeuchi, J. Tedds, P. Temi, R. Tuffs, M. Trichas, M. Vaccari, I. Valtchanov, P. van der Werf, A. Verma, J. Vieria, C. Vlahakis, Glenn J. White, and Science and Technology Facilities Council (STFC)
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), submmilimeter, media_common.quotation_subject, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, 01 natural sciences, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, BRIGHT QUASAR SURVEY, NUMBER COUNTS, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, media_common, Physics, instrumentation, DEGREE EXTRAGALACTIC SURVEY, Science & Technology, 010308 nuclear & particles physics, Atlas (topology), Astrophysics::Instrumentation and Methods for Astrophysics, Galaxies, Astronomy and Astrophysics, 1200-MU-M MAMBO SURVEY, STAR-FORMATION HISTORY, Space observatory, Galaxy, 0201 Astronomical And Space Sciences, Space and Planetary Science, Sky, Physical Sciences, GOODS-N FIELD, astro-ph.CO, Square (unit), DIGITAL SKY SURVEY, HIGH-REDSHIFT, STELLAR MASS, UNIVERSE GALAXY SURVEY, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: 17 páginas, 11 figuras, 4 tablas.-- El Pdf del artículo es la versión pre-print: arXiv:0910.4279v1.-- et al., The Herschel ATLAS is the largest open-time key project that will be carried out on the Herschel Space Observatory. It will survey 570 deg2 of the extragalactic sky, 4 times larger than all the other Herschel extragalactic surveys combined, in five far-infrared and submillimeter bands. We describe the survey, the complementary multiwavelength data sets that will be combined with the Herschel data, and the six major science programs we are undertaking. Using new models based on a previous submillimeter survey of galaxies, we present predictions of the properties of the ATLAS sources in other wave bands.
Published: 2010

50. The Herschel-SPIRE instrument and its in-flight performance

Author: M. J. Griffin, A. Abergel, A. Abreu, P. A. R. Ade, P. André, J.-L. Augueres, T. Babbedge, Y. Bae, T. Baillie, J.-P. Baluteau, M. J. Barlow, G. Bendo, D. Benielli, J. J. Bock, P. Bonhomme, D. Brisbin, C. Brockley-Blatt, M. Caldwell, C. Cara, N. Castro-Rodriguez, R. Cerulli, P. Chanial, S. Chen, E. Clark, D. L. Clements, L. Clerc, J. Coker, D. Communal, L. Conversi, P. Cox, D. Crumb, C. Cunningham, F. Daly, G. R. Davis, P. De Antoni, J. Delderfield, N. Devin, A. Di Giorgio, I. Didschuns, K. Dohlen, M. Donati, A. Dowell, C. D. Dowell, L. Duband, L. Dumaye, R. J. Emery, M. Ferlet, D. Ferrand, J. Fontignie, M. Fox, A. Franceschini, M. Frerking, T. Fulton, J. Garcia, R. Gastaud, W. K. Gear, J. Glenn, A. Goizel, D. K. Griffin, T. Grundy, S. Guest, L. Guillemet, P. C. Hargrave, M. Harwit, P. Hastings, E. Hatziminaoglou, M. Herman, B. Hinde, V. Hristov, M. Huang, P. Imhof, K. J. Isaak, U. Israelsson, R. J. Ivison, D. Jennings, B. Kiernan, K. J. King, A. E. Lange, W. Latter, G. Laurent, P. Laurent, S. J. Leeks, E. Lellouch, L. Levenson, B. Li, J. Li, J. Lilienthal, T. Lim, S. J. Liu, N. Lu, S. Madden, G. Mainetti, P. Marliani, D. McKay, K. Mercier, S. Molinari, H. Morris, H. Moseley, J. Mulder, M. Mur, D. A. Naylor, H. Nguyen, B. O'Halloran, S. Oliver, G. Olofsson, H.-G. Olofsson, R. Orfei, M. J. Page, I. Pain, P. Panuzzo, A. Papageorgiou, G. Parks, P. Parr-Burman, A. Pearce, C. Pearson, I. Pérez-Fournon, F. Pinsard, G. Pisano, J. Podosek, M. Pohlen, E. T. Polehampton, D. Pouliquen, D. Rigopoulou, D. Rizzo, I. G. Roseboom, H. Roussel, M. Rowan-Robinson, B. Rownd, P. Saraceno, M. Sauvage, R. Savage, G. Savini, E. Sawyer, C. Scharmberg, D. Schmitt, N. Schneider, B. Schulz, A. Schwartz, R. Shafer, D. L. Shupe, B. Sibthorpe, S. Sidher, A. Smith, A. J. Smith, D. Smith, L. Spencer, B. Stobie, R. Sudiwala, K. Sukhatme, C. Surace, J. A. Stevens, B. M. Swinyard, M. Trichas, T. Tourette, H. Triou, S. Tseng, C. Tucker, A. Turner, M. Vaccari, I. Valtchanov, L. Vigroux, E. Virique, G. Voellmer, H. Walker, R. Ward, T. Waskett, M. Weilert, R. Wesson, G. J. White, N. Whitehouse, C. D. Wilson, B. Winter, A. L. Woodcraft, G. S. Wright, C. K. Xu, A. Zavagno, M. Zemcov, L. Zhang, E. Zonca, Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: FOS: Physical sciences, Field of view, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, law.invention, Telescope, Optics, law, 0103 physical sciences, instrumentation: photometers, instrumentation: spectrographs, space vehicles: instruments, submillimeter: general, [INFO]Computer Science [cs], Spectral resolution, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS, QB, Physics, Instrument control, Spectrometer, 010308 nuclear & particles physics, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Spectral bands, Photometer, Spire, Space and Planetary Science, Astrophysics - Instrumentation and Methods for Astrophysics, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The Spectral and Photometric Imaging Receiver (SPIRE), is the Herschel Space Observatory`s submillimetre camera and spectrometer. It contains a three-band imaging photometer operating at 250, 350 and 500 microns, and an imaging Fourier Transform Spectrometer (FTS) which covers simultaneously its whole operating range of 194-671 microns (447-1550 GHz). The SPIRE detectors are arrays of feedhorn-coupled bolometers cooled to 0.3 K. The photometer has a field of view of 4' x 8', observed simultaneously in the three spectral bands. Its main operating mode is scan-mapping, whereby the field of view is scanned across the sky to achieve full spatial sampling and to cover large areas if desired. The spectrometer has an approximately circular field of view with a diameter of 2.6'. The spectral resolution can be adjusted between 1.2 and 25 GHz by changing the stroke length of the FTS scan mirror. Its main operating mode involves a fixed telescope pointing with multiple scans of the FTS mirror to acquire spectral data. For extended source measurements, multiple position offsets are implemented by means of an internal beam steering mirror to achieve the desired spatial sampling and by rastering of the telescope pointing to map areas larger than the field of view. The SPIRE instrument consists of a cold focal plane unit located inside the Herschel cryostat and warm electronics units, located on the spacecraft Service Module, for instrument control and data handling. Science data are transmitted to Earth with no on-board data compression, and processed by automatic pipelines to produce calibrated science products. The in-flight performance of the instrument matches or exceeds predictions based on pre-launch testing and modelling: the photometer sensitivity is comparable to or slightly better than estimated pre-launch, and the spectrometer sensitivity is also better by a factor of 1.5-2., Comment: Accepted for publication in Astronomy & Astrophyics (Herschel first results special issue)
Published: 2010
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