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Burger and Fisher diffusion transfer properties and reactions from the characteristics are studied using a non-linear equation. The nonlinear fractional Burgers–Fisher equation (NFB-FE) appears in realistic physical situations such as ultra-slow kinetics, Brownian motion of particles, anomalous diffusion, polymerases of ribonucleic acid and deoxyribonucleic acid, continuous random movement, and formation of wave patterns. The present study focuses on the collocation scheme based on the shifted Chebyshev basis (SCB) and the compact finite difference method to obtain the numerical scheme of the NFB-FE. The simulation model is created in the two steps: Initially, a semi-discrete is formed in a temporal sense, applying a linear approximation with an accuracy order of two. Next, we examine the unconditional stability and the convergence order. In the second stage, the collocation approach based on the SCB of the fourth type is used to discretize the spatial derivative parts and generate the full-discrete scheme.