1,983 results on '"M. Varela"'
Search Results
2. P1335: SECONDARY MALIGNANCIES AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION. SINGLE HOSPITAL EXPERIENCE.
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A. Dorado López, M. Calviño Suárez, E. Lavilla Rubira, P. Sar Fuentes, J. A. Arias Sampedro, L. Lopez Gonzalez, M. J. Sánchez Sánchez, and M. Varela Pérez
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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3. Ferroionic inversion of spin polarization in a spin-memristor
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V. Rouco, F. Gallego, D. Hernandez-Martin, D. Sanchez-Manzano, J. Tornos, J. I. Beltran, M. Cabero, F. Cuellar, D. Arias, G. Sanchez-Santolino, F. J. Mompean, M. Garcia-Hernandez, A. Rivera-Calzada, M. Varela, M. C. Muñoz, C. Leon, Z. Sefrioui, and J. Santamaria
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Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
Magnetoelectric coupling in artificial multiferroic interfaces can be drastically affected by the switching of oxygen vacancies and by the inversion of the ferroelectric polarization. Disentangling both effects is of major importance toward exploiting these effects in practical spintronic or spinorbitronic devices. We report on the independent control of ferroelectric and oxygen vacancy switching in multiferroic tunnel junctions with a La0.7Sr0.3MnO3 bottom electrode, a BaTiO3 ferroelectric barrier, and a Ni top electrode. We show that the concurrence of interface oxidation and ferroelectric switching allows for the controlled inversion of the interface spin polarization. Moreover, we show the possibility of a spin-memristor where the controlled oxidation of the interface allows for a continuum of memresistance states in the tunneling magnetoresistance. These results signal interesting new avenues toward neuromorphic devices where, as in practical neurons, the electronic response is controlled by electrochemical degrees of freedom.
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- 2021
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4. Two Synchronous Neonatal Tumors: An Extremely Rare Case
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M. Rodríguez-Zubieta, K. Albarenque, C. Lagues, A. San Roman, M. Varela, D. Russo, G. Podesta, D. Steinberg, C. Schauvinhold, A. Etchegaray, and M. T. G. de Dávila
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Pathology ,RB1-214 - Abstract
We report a case of a newborn with two synchronous tumors—sialoblastoma and hepatoblastoma—diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study was to describe the management of this case together with a review of the literature. Our patient had a large facial tumor associated with extremely high alpha-fetoprotein levels. Diagnosis of the tumors was made by surgical biopsy, showing typical features in both. Sialoblastoma is a potentially aggressive tumor. In our case, the Ki67 index in the sialoblastoma was between 20 and 30%, indicating a possibly unfavorable behavior. The infant underwent surgery and chemotherapy in different steps. Complete surgical resection with clean margins is considered to be the best treatment option for sialoblastoma. Only four similar cases were previously reported. Timely management by a multidisciplinary team is essential in these difficult cases. In our patient, outcome was good at the time of this report.
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- 2021
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5. Morphine with or without Acepromazine in Horses: A Kinematic Evaluation
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F. Javier López-Sanromán, G. Montes Freilich, D. Gómez-Cisneros, J. Izquierdo-Moreno, M. Varela del Arco, and G. Manso-Díaz
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gait analysis ,accelerometry ,acepromazine ,morphine ,horse ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
The objective was to demonstrate walking locomotor pattern alterations after co-administration of acepromazine and morphine in horses. Six mature horses receiving four different treatments were used. Treatments consisted of a single dose of saline solution, 0.2 mg/kg bwt of morphine hydrochloride, 0.02 mg/kg bwt of acepromazine maleate, and a combination of 0.2 mg/kg bwt of morphine hydrochloride with 0.02 mg/kg bwt of acepromazine maleate. A three-dimensional accelerometric device was used to collect data. Walking tests were performed 10 min prior to injection, and then at 5, 10, 15, and 20 min after the injection, and then every 10 min for 3 h. Eight variables were calculated including stride kinematic, coordination, and energetic parameters; moreover ground-to-lip distance (GLD), as a tranquilization parameter, was also measured. A significant interaction was observed in all the variables studied but regularity, mediolateral power, the propulsive part of the power, and the GLD. An evident counteraction of the effects caused by both, opioids and phenothiazines, in the gait pattern was observed. The co-administration of acepromazine and morphine could allow a safe opiate administration while minimizing the possible central nervous system (CNS) excitation and reducing potential locomotor adverse effects.
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- 2022
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6. Enhanced figure of merit in nanostructured (Bi,Sb)2Te3 with optimized composition, prepared by a straightforward arc-melting procedure
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F. Serrano-Sánchez, M. Gharsallah, N. M. Nemes, N. Biskup, M. Varela, J. L. Martínez, M. T. Fernández-Díaz, and J. A. Alonso
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Medicine ,Science - Abstract
Abstract Sb-doped Bi2Te3 is known since the 1950s as the best thermoelectric material for near-room temperature operation. Improvements in material performance are expected from nanostructuring procedures. We present a straightforward and fast method to synthesize already nanostructured pellets that show an enhanced ZT due to a remarkably low thermal conductivity and unusually high Seebeck coefficient for a nominal composition optimized for arc-melting: Bi0.35Sb1.65Te3. We provide a detailed structural analysis of the Bi2−xSbxTe3 series (0 ≤ x ≤ 2) based on neutron powder diffraction as a function of composition and temperature that reveals the important role played by atomic vibrations. Arc-melting produces layered platelets with less than 50 nm-thick sheets. The low thermal conductivity is attributed to the phonon scattering at the grain boundaries of the nanosheets. This is a fast and cost-effective production method of highly efficient thermoelectric materials.
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- 2017
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7. Epitaxial Growth of SrTiO3 Films on Cube-Textured Cu-Clad Substrates by PLD at Low Temperature Under Reducing Atmosphere
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J. A. Padilla, E. Xuriguera, L. Rodríguez, A. Vannozzi, M. Segarra, G. Celentano, and M. Varela
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Epitaxy ,Thin film texture ,High-temperature superconductivity ,Pulsed laser deposition ,Electron diffraction ,X-ray diffraction ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract The growth of epitaxial {001} SrTiO3 (STO) on low-cost cube-textured Cu-based clad substrate at low temperature was carried out by means of pulsed laser deposition (PLD). STO film was deposited in one step under a reducing atmosphere (5% H2 and 95% Ar mixture) to prevent the oxidation of the metal surface. The optimization of PLD parameters leads to a sharpest biaxial texture at a temperature as low as 500 °C and a thickness of 500 nm with a (100) STO layer. The upper limit of highly textured STO thickness was also investigated. The maximum thickness which retains the best quality {001} texture is 800 nm, since the texture is preserved not only through the layer but also on the surface. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) measurements showed that STO films are continuous, dense, and smooth with very low roughness (between 5 and 7 nm). This paper describes the development of STO layer by means of PLD in absence of oxygen throughout the process, suggesting an alternative and effective method for growing highly {001} textured STO layer on low-cost metal substrates.
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- 2017
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8. Effect of different buffer layers on the quality of InGaN layers grown on Si
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V. J. Gómez, J. Grandal, A. Núñez-Cascajero, F. B. Naranjo, M. Varela, M. A. Sánchez-García, and E. Calleja
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Physics ,QC1-999 - Abstract
This work studies the effect of four different types of buffer layers on the structural and optical properties of InGaN layers grown on Si(111) substrates and their correlation with electrical characteristics. The vertical electrical conduction of n-InGaN/buffer-layer/p-Si heterostructures, with In composition near 46%, which theoretically produces an alignment of the bands, is analyzed. Droplet elimination by radical-beam irradiation was successfully applied to grow high quality InGaN films on Si substrates for the first time. Among several buffer choices, an AlN buffer layer with a thickness above 24 nm improves the structural and optical quality of the InGaN epilayer while keeping a top to bottom ohmic behavior. These results will allow fabricating double-junction InGaN/Si solar cells without the need of tunnel junctions between the two sub-cells, therefore simplifying the device design.
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- 2018
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9. Modified magnetic anisotropy at LaCoO3/La0.7Sr0.3MnO3 interfaces
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M. Cabero, K. Nagy, F. Gallego, A. Sander, M. Rio, F. A. Cuellar, J. Tornos, D. Hernandez-Martin, N. M. Nemes, F. Mompean, M. Garcia-Hernandez, A. Rivera-Calzada, Z. Sefrioui, N. Reyren, T. Feher, M. Varela, C. Leon, and J. Santamaria
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Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
Controlling magnetic anisotropy is an important objective towards engineering novel magnetic device concepts in oxide electronics. In thin film manganites, magnetic anisotropy is weak and it is primarily determined by the substrate, through induced structural distortions resulting from epitaxial mismatch strain. On the other hand, in cobaltites, with a stronger spin orbit interaction, magnetic anisotropy is typically much stronger. In this paper, we show that interfacing La0.7Sr0.3MnO3 (LSMO) with an ultrathin LaCoO3 (LCO) layer drastically modifies the magnetic anisotropy of the manganite, making it independent of the substrate and closer to the magnetic isotropy characterizing its rhombohedral structure. Ferromagnetic resonance measurements evidence a tendency of manganite magnetic moments to point out-of-plane suggesting non collinear magnetic interactions at the interface. These results may be of interest for the design of oxide interfaces with tailored magnetic structures for new oxide devices.
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- 2017
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10. A CityGML extension for traffic-sign objects that guides the automatic processing of data collected using Mobile Mapping technology
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M. Varela-González, B. Riveiro, P. Arias-Sánchez, H. González-Jorge, and J. Martínez-Sánchez
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
The rapid evolution of integral schemes, accounting for geometric and semantic data, has been importantly motivated by the advances in the last decade in mobile laser scanning technology; automation in data processing has also recently influenced the expansion of the new model concepts. This paper reviews some important issues involved in the new paradigms of city 3D modelling: an interoperable schema for city 3D modelling (cityGML) and mobile mapping technology to provide the features that composing the city model. This paper focuses in traffic signs, discussing their characterization using cityGML in order to ease the implementation of LiDAR technology in road management software, as well as analysing some limitations of the current technology in the labour of automatic detection and classification.
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- 2014
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11. Performance testing of 3D point cloud software
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M. Varela-González, H. González-Jorge, B. Riveiro, and P. Arias
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
LiDAR systems are being used widely in recent years for many applications in the engineering field: civil engineering, cultural heritage, mining, industry and environmental engineering. One of the most important limitations of this technology is the large computational requirements involved in data processing, especially for large mobile LiDAR datasets. Several software solutions for data managing are available in the market, including open source suites, however, users often unknown methodologies to verify their performance properly. In this work a methodology for LiDAR software performance testing is presented and four different suites are studied: QT Modeler, VR Mesh, AutoCAD 3D Civil and the Point Cloud Library running in software developed at the University of Vigo (SITEGI). The software based on the Point Cloud Library shows better results in the loading time of the point clouds and CPU usage. However, it is not as strong as commercial suites in working set and commit size tests.
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- 2013
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12. Tratamiento biológico de la hidatidosis
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V. M. VARELA-DIAZ and N. MARCHEVSKY
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Medicine - Published
- 2024
13. Applied Research Note: Bacterial profile in the environment of an egg-producing farm in Southern Brazil
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Mariana C. Torres, Gabriela M. Breyer, Fabiana Q. Mayer, Ana Paula M. Varela, Marisa R. de I. Cardoso, and Franciele M. Siqueira
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poultry ,laying hen ,composting ,16S-rDNA analysis ,Animal culture ,SF1-1100 ,Food processing and manufacture ,TP368-456 - Abstract
SUMMARY: This study aims to characterize the environmental microbiota of an egg-producing farm situated in Rio Grande do Sul, Southern Brazil, spanning from the chick to the laying hen stages and encompassing the treatment of carcasses and manure. Metataxonomy analyses reveal the continuity of bacterial diversity across the production stages (chick, pullet, and laying hen). The presence of Fusobacteriota and Cyanobacteria in poultry environments before any manure or carcass treatments (named pre-treatment samples) are identified as indicative phyla markers for healthy animals. Nonetheless, alterations in the bacterial communities emerge during the treatment of manure and carcasses (treatment samples), revealing an increased abundance of Halanaerobiaeota. In summary, the study underscores the key phyla influencing the entire environment of the egg production process on a farm in South Brazil. Although our data is from a specific farm, it provides insights for a more robust and representative study of the egg chain.
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- 2024
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14. A global diatom database – abundance, biovolume and biomass in the world ocean
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K. Leblanc, J. Arístegui, L. Armand, P. Assmy, B. Beker, A. Bode, E. Breton, V. Cornet, J. Gibson, M.-P. Gosselin, E. Kopczynska, H. Marshall, J. Peloquin, S. Piontkovski, A. J. Poulton, B. Quéguiner, R. Schiebel, R. Shipe, J. Stefels, M. A. van Leeuwe, M. Varela, C. Widdicombe, and M. Yallop
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Phytoplankton identification and abundance data are now commonly feeding plankton distribution databases worldwide. This study is a first attempt to compile the largest possible body of data available from different databases as well as from individual published or unpublished datasets regarding diatom distribution in the world ocean. The data obtained originate from time series studies as well as spatial studies. This effort is supported by the Marine Ecosystem Model Inter-Comparison Project (MAREMIP), which aims at building consistent datasets for the main plankton functional types (PFTs) in order to help validate biogeochemical ocean models by using carbon (C) biomass derived from abundance data. In this study we collected over 293 000 individual geo-referenced data points with diatom abundances from bottle and net sampling. Sampling site distribution was not homogeneous, with 58% of data in the Atlantic, 20% in the Arctic, 12% in the Pacific, 8% in the Indian and 1% in the Southern Ocean. A total of 136 different genera and 607 different species were identified after spell checking and name correction. Only a small fraction of these data were also documented for biovolumes and an even smaller fraction was converted to C biomass. As it is virtually impossible to reconstruct everyone's method for biovolume calculation, which is usually not indicated in the datasets, we decided to undertake the effort to document, for every distinct species, the minimum and maximum cell dimensions, and to convert all the available abundance data into biovolumes and C biomass using a single standardized method. Statistical correction of the database was also adopted to exclude potential outliers and suspicious data points. The final database contains 90 648 data points with converted C biomass. Diatom C biomass calculated from cell sizes spans over eight orders of magnitude. The mean diatom biomass for individual locations, dates and depths is 141.19 μg C l−1, while the median value is 11.16 μg C l−1. Regarding biomass distribution, 19% of data are in the range 0–1 μg C l−1, 29% in the range 1–10 μg C l−1, 31% in the range 10–100 μg C l−1, 18% in the range 100–1000 μg C l−1, and only 3% > 1000 μg C l−1. Interestingly, less than 50 species contributed to > 90% of global biomass, among which centric species were dominant. Thus, placing significant efforts on cell size measurements, process studies and C quota calculations of these species should considerably improve biomass estimates in the upcoming years. A first-order estimate of the diatom biomass for the global ocean ranges from 444 to 582 Tg C, which converts to 3 to 4 Tmol Si and to an average Si biomass turnover rate of 0.15 to 0.19 d−1. Link to the dataset: doi:10.1594/PANGAEA.777384.
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- 2012
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15. Database of diazotrophs in global ocean: abundance, biomass and nitrogen fixation rates
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Y.-W. Luo, S. C. Doney, L. A. Anderson, M. Benavides, I. Berman-Frank, A. Bode, S. Bonnet, K. H. Boström, D. Böttjer, D. G. Capone, E. J. Carpenter, Y. L. Chen, M. J. Church, J. E. Dore, L. I. Falcón, A. Fernández, R. A. Foster, K. Furuya, F. Gómez, K. Gundersen, A. M. Hynes, D. M. Karl, S. Kitajima, R. J. Langlois, J. LaRoche, R. M. Letelier, E. Marañón, D. J. McGillicuddy Jr., P. H. Moisander, C. M. Moore, B. Mouriño-Carballido, M. R. Mulholland, J. A. Needoba, K. M. Orcutt, A. J. Poulton, E. Rahav, P. Raimbault, A. P. Rees, L. Riemann, T. Shiozaki, A. Subramaniam, T. Tyrrell, K. A. Turk-Kubo, M. Varela, T. A. Villareal, E. A. Webb, A. E. White, J. Wu, and J. P. Zehr
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Marine N2 fixing microorganisms, termed diazotrophs, are a key functional group in marine pelagic ecosystems. The biological fixation of dinitrogen (N2) to bioavailable nitrogen provides an important new source of nitrogen for pelagic marine ecosystems and influences primary productivity and organic matter export to the deep ocean. As one of a series of efforts to collect biomass and rates specific to different phytoplankton functional groups, we have constructed a database on diazotrophic organisms in the global pelagic upper ocean by compiling about 12 000 direct field measurements of cyanobacterial diazotroph abundances (based on microscopic cell counts or qPCR assays targeting the nifH genes) and N2 fixation rates. Biomass conversion factors are estimated based on cell sizes to convert abundance data to diazotrophic biomass. The database is limited spatially, lacking large regions of the ocean especially in the Indian Ocean. The data are approximately log-normal distributed, and large variances exist in most sub-databases with non-zero values differing 5 to 8 orders of magnitude. Reporting the geometric mean and the range of one geometric standard error below and above the geometric mean, the pelagic N2 fixation rate in the global ocean is estimated to be 62 (52–73) Tg N yr−1 and the pelagic diazotrophic biomass in the global ocean is estimated to be 2.1 (1.4–3.1) Tg C from cell counts and to 89 (43–150) Tg C from nifH-based abundances. Reporting the arithmetic mean and one standard error instead, these three global estimates are 140 ± 9.2 Tg N yr−1, 18 ± 1.8 Tg C and 590 ± 70 Tg C, respectively. Uncertainties related to biomass conversion factors can change the estimate of geometric mean pelagic diazotrophic biomass in the global ocean by about ±70%. It was recently established that the most commonly applied method used to measure N2 fixation has underestimated the true rates. As a result, one can expect that future rate measurements will shift the mean N2 fixation rate upward and may result in significantly higher estimates for the global N2 fixation. The evolving database can nevertheless be used to study spatial and temporal distributions and variations of marine N2 fixation, to validate geochemical estimates and to parameterize and validate biogeochemical models, keeping in mind that future rate measurements may rise in the future. The database is stored in PANGAEA (doi:10.1594/PANGAEA.774851).
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- 2012
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16. Latitudinal distribution of Trichodesmium spp. and N2 fixation in the Atlantic Ocean
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E. Marañón, M. Varela, A. Bode, B. Mouriño-Carballido, and A. Fernández
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
We have determined the latitudinal distribution of Trichodesmium spp. abundance and community N2 fixation in the Atlantic Ocean along a meridional transect from ca. 30° N to 30° S in November–December 2007 and April–May 2008. The observations from both cruises were highly consistent in terms of absolute magnitude and latitudinal distribution, showing a strong association between Trichodesmium abundance and community N2 fixation. The highest Trichodesmium abundances (mean = 220 trichomes L−1,) and community N2 fixation rates (mean = 60 μmol m−2 d−1) occurred in the Equatorial region between 5° S–15° N. In the South Atlantic gyre, Trichodesmium abundance was very low (ca. 1 trichome L−1) but N2 fixation was always measurable, averaging 3 and 10 μmol m2 d−1 in 2007 and 2008, respectively. We suggest that N2 fixation in the South Atlantic was sustained by other, presumably unicellular, diazotrophs. Comparing these distributions with the geographical pattern in atmospheric dust deposition points to iron supply as the main factor determining the large scale latitudinal variability of Trichodesmium spp. abundance and N2 fixation in the Atlantic Ocean. We observed a marked South to North decrease in surface phosphate concentration, which argues against a role for phosphorus availability in controlling the large scale distribution of N2 fixation. Scaling up from all our measurements (42 stations) results in conservative estimates for total N2 fixation of ∼6 TgN yr−1 in the North Atlantic (0–40° N) and ~1.2 TgN yr−1 in the South Atlantic (0–40° S).
- Published
- 2010
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17. Perfil de preferencias de aprendizaje de alumnos y profesores de medicina: Elemento a considerar en la enseñanza Profile of learning preferences of students and professors of medicine: Element to consider in teaching
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M.E. Ponce de León-Castañeda, M. Varela-Ruiz, J.R. Lozano-Sánchez, A. Ortiz-Montalvo, and R.E. Ponce-Rosas
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Alumno ,Estilos de aprendizaje ,Profesor ,VARK ,Learning strategies ,Student ,Teacher ,Education (General) ,L7-991 ,Medicine (General) ,R5-920 - Abstract
Introducción. Es importante que alumnos y profesores comprendan y desarrollen habilidades que favorezcan un mejor aprendizaje. Para ello se debe identificar sus perfiles de aprendizaje. Sujetos y métodos. Con autorización del autor se aplicó el cuestionario VARK a 530 alumnos y 27 profesores del primer año de la carrera de Medicina en la Universidad Nacional Autónoma de México. Las respuestas al cuestionario se procesaron con la metodología establecida por el autor. Se utilizó la prueba exacta de Fisher para identificar diferencias entre ambos perfiles. Mediante análisis inferencial se buscó asociación por género y con el promedio de calificaciones, así como entre profesor y alumnos. Resultados. El 31% de alumnos presentó una modalidad, y el 69%, más de una; de éstos, el 14% desarrolló las cuatro modalidades. El 41% fueron visual/cinestésicos, y el 64% desarrolló una o dos modalidades. De los profesores, el 26% manifestó una modalidad, y el 74%, más de una; de ellos, el 4% tuvo las cuatro modalidades. No se encontraron diferencias estadísticamente significativas entre mujeres y hombres, ni entre los grupos matutinos, vespertinos o de alto rendimiento. Conclusiones. Este primer acercamiento permitió tener una visión general de las preferencias de aprendizaje de la población estudiada. Los resultados permitirán que cuando profesores y alumnos reconozcan su estilo de aprendizaje, podrán enriquecer su práctica docente y acercarla a las necesidades de sus alumnos, y con ello mejorar el proceso de enseñanza y los resultados del aprendizaje.Introduction. It is important for students and teachers to identify their learning profiles. Subjects and methods. The consent of the author was solicited to translate and apply the VARK questionnaire to 530 students and 27 professors of Public Health course, which is given at first year medical students. Fisher's exact test was used to identify the existence of differences between the learning profiles of the professors and the learning modalities of the students and then both compared with the averages of grades separated by group. By means of inferential analysis the association between gender and group characteristics with the average grades looked for. Results. 31%, of the students displayed a single modality of learning, and 69% declared more than one learning modality; and of these last ones 14% said they development all four modalities. It is interesting to note that 41% are visual/kinesthetic and 64% of the students displayed of one to two modalities. About the teachers 26% used only one teaching modality, 74% used more than one, and 4% used all four modalities. There were no statistical significance differences between women and men neither between, morning and afternoon groups nor with high performance groups. Conclusions. This first approach allowed us to have a general vision of the preferences of learning in the studied population. When the teacher identifies how their students learn and also recognizes his/her own, he/she can enrich their educational practice, and approach it to the necessities of the students and, that way improve the teaching process and better the student's results.
- Published
- 2010
18. Diagnóstico precoz del cáncer primario de hígado: imagen versus genética Early diagnosis of primary liver cancer: imaging versus genetics
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A. Forner, C. Rodríguez de Lope, M. Reig, J. Rimola, and M. Varela
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Hepatocarcinoma ,Diagnóstico precoz ,Técnicas de imagen ,Marcadores tumorales ,Inmunohistoquímica ,PCR ,Hepatocellular carcinoma ,Early diagnosis ,Imaging techniques ,Tumor markers ,Immunohistochemistry ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
El diagnóstico precoz del carcinoma hepatocelular (CHC) es fundamental, especialmente si se consigue cuando los nódulos son menores de 2 cm, dado que en esta fase la mayoría aún no han presentado invasión vascular y la aplicación de tratamientos radicales se acompaña de una alta tasa de supervivencia a largo plazo. Los avances en las técnicas de imagen en los últimos años han permitido llegar a un diagnóstico concluyente de CHC en algunos de estos nódulos de pequeño tamaño sin necesidad de realizar procedimientos invasivos. Sin embargo, el número de CHC que pueden ser diagnosticados mediante pruebas de imagen es bajo y en más de la mitad de los casos sigue siendo necesaria la realización de una biopsia. Por otro lado, la confirmación histológica de CHC en este tipo de nódulos es compleja y en muchas ocasiones imposible, dado el posible error de muestreo y la dificultad para diferenciar CHC bien diferenciado de nódulos displásicos en una muestra habitualmente con escaso material. Además, los marcadores tumorales séricos disponibles en la actualidad presentan un bajo rendimiento y carecen de utilidad en el diagnóstico precoz de CHC. Los progresos en el conocimiento de los mecanismos moleculares responsables de la transformación maligna permitirán aplicar una serie de técnicas de biología molecular para facilitar el diagnóstico de CHC de forma precoz, con resultados iniciales prometedores.Early diagnosis of hepatocellular carcinoma (HCC) in nodules smaller than 2 cm detected by screening ultrasounds becomes essential given that, at that stage, no vascular invasion is usually detected and treatment is associated with a high rate of long-term survival. Improvements in imaging techniques in the last few years have allowed a conclusive diagnosis of HCC in these small nodules without invasive procedures. However, a conclusive diagnosis of HCC by imaging is not always possible and, in more than half of cases, biopsy is needed. On the other hand, histological confirmation of HCC in such tiny nodules is very complex, and in most cases impossible because of the limited sample obtained. In addition, serum tumor markers currently available show low accuracy and are useless for early diagnosis. Progress in the knowledge of molecular mechanisms associated with malignant transformation will allow the use of new techniques that will facilitate diagnosis for HCC in very early stages.
- Published
- 2008
19. Indolent evolution of an episode of acute gastroenteritis complicated with portal pneumatosis Resolución espontánea de neumatosis portal tras un episodio de gastroenteritis aguda
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A. Mancebo, E. Álvarez-Hornia, M. Rodríguez-Peláez, M. Ibáñez, L. H. Luyando, and M. Varela
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Neumatosis portal ,Gastroenteritis aguda ,Streptococus viridans ,Portal pneumatosis ,Acute gastroenteritis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The discovery of gas in the portal system related to indolent clinical settings has increased in recent years due to a growth in the performance of imaging tests. We report the first case of spontaneous resolution of portal pneumatosis due to acute gastroenteritis described in the literature.El hallazgo de gas en el sistema portal en relación a cuadros de evolución indolente ha aumentado en los últimos años por la mayor realización de pruebas de imagen. Creemos importante destacar que, a pesar de los hallazgos radiológicos, el sentido clínico es lo más importante a la hora de enfocar el diagnóstico. Presentamos el primer caso en la literatura de neumatosis portal secundaria a un cuadro de gastroenteritis aguda, con resolución espontánea.
- Published
- 2010
20. Lattice mismatch accommodation via oxygen vacancy ordering in epitaxial La0.5Sr0.5CoO3-δ thin films
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J. Gazquez, Shameek Bose, M. Sharma, M. A. Torija, S. J. Pennycook, C. Leighton, and M. Varela
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Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
The properties of complex oxide films depend sensitively on epitaxial strain. This strain affects bond lengths and angles, and defect types and densities, thus impacting physical properties. In this work we perform detailed characterization of depth-dependent strain in epitaxial La0.5Sr0.5CoO3-δ (LSCO) films on SrTiO3(001), SrTiO3(110), and LaAlO3(001) substrates, combining high resolution x-ray diffraction and scanning transmission electron microscopy, in addition to geometric phase analysis. We elucidate a fundamental link between strain state and O vacancy ordering in LSCO films, where lattice mismatch and crystallographic orientation can be used to manipulate the modulation vector of the long-range vacancy order, thus providing a new approach to tailor the properties of such films.
- Published
- 2013
- Full Text
- View/download PDF
21. Ginger Phytotoxicity: Potential Efficacy of Extracts, Metabolites and Derivatives for Weed Control
- Author
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Jesús G. Zorrilla, Carlos Rial, Miriam I. Martínez-González, José M. G. Molinillo, Francisco A. Macías, and Rosa M. Varela
- Subjects
weed management ,bioassays ,natural products ,phenolic compounds ,shogaol ,gingerol ,Agriculture - Abstract
The negative implications for weeds encourage the finding of novel sources of phytotoxic agents for sustainable management. While traditional herbicides are effective, especially at large scales, the environmental impact and proliferation of resistant biotypes present major challenges that natural sources could mitigate. In this study, the potential of ginger metabolites as phytotoxic agents has been investigated for the first time. Root extracts, prepared via various extraction techniques, showed phytotoxicity in wheat (Triticum aestivum L. cv. Burgos) coleoptile bioassays at 800–100 ppm, and the most active extract (prepared by sonication with ethyl acetate) was purified by chromatographic methods, yielding seven compounds: five phenolic metabolites with gingerol and shogaol structures, β-sitosterol, and linoleic acid. Some of the major phenolic metabolites, especially [6]-shogaol and [6]-gingerol, exerted phytotoxicity on wheat coleoptiles, Plantago lanceolata and Portulaca oleracea (broadleaf dicotyledon weeds). This promoted the study of a collection of derivatives, revealing that the 5-methoxy, oxime, and acetylated derivatives of [6]-shogaol and [6]-gingerol had interesting phytotoxicities, providing clues for improving the stability of the isolated structures. Ginger roots have been demonstrated to be a promising source of bioactive metabolites for weed control, offering novel materials with potential for the development of agrochemicals based on natural products.
- Published
- 2024
- Full Text
- View/download PDF
22. Phytotoxic Activity of Sesquiterpene Lactones-Enriched Fractions from Cynara cardunculus L. Leaves on Pre-Emergent and Post-Emergent Weed Species and Putative Mode of Action
- Author
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Daniela Rosa, Carlos Rial, Teresa Brás, Rosa M. Varela, Francisco A. Macías, and Maria F. Duarte
- Subjects
allelochemicals ,sesquiterpene lactones ,Cynara cardunculus L. ,phytotoxicity ,weed control ,Portulaca oleracea L. ,Botany ,QK1-989 - Abstract
Sesquiterpene lactones (SLs) are compounds that are highly produced in Cynara cardunculus leaves, known for their phytotoxic activity. This study aims to assess SL-enriched fractions’ (cynaropicrin, aguerin B, and grosheimin) phytotoxic potentials and putative modes of action, compared to an initial extract, using two approaches: first, against a panel of nine weed species in pre-emergence, and then on Portulaca oleracea L.’s post-emergency stage. The SL-enriched fractions demonstrated greater phytotoxic activity when compared with the C. cardunculus leaf initial extract. The SL-enriched fractions had higher activity at root growth inhibition over the panel tested, doubling the activity in five of them at 800 ppm. Regarding the post-emergence bioassay, the SL-enriched fractions had a higher influence on the plants’ growth inhibition (67% at 800 ppm). The SL-effects on the plants’ metabolisms were evidenced. The total chlorophyll content was reduced by 65% at 800 ppm. Oxidative stress induction was observed because of the enhancement in MDA levels at 800 ppm compared to control (52%) and the decrease in SOD-specific activity from 4.20 U/mg protein (400 ppm) to 1.74 U/mg protein (800 ppm). The phytotoxic effects of the SL-enriched fractions suggest that they could be used for a future bioherbicide development.
- Published
- 2024
- Full Text
- View/download PDF
23. Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease
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Daniela Liempi, Inés Zulantay, Nelson M. Varela, Mauricio Canals, Andrés Guevara, Nicolás Poulsen, and Werner Apt
- Subjects
chronic Chagas disease ,buffy coat ,guanidine ,parasitemia ,real-time PCR ,Biology (General) ,QH301-705.5 - Abstract
The objective of this study was to compare, by qPCR, the circulating blood parasite load of Trypanosoma cruzi in the buffy coat, and in whole blood mixed with boiled and unboiled guanidine hydrochloride-EDTA buffer, of individuals with chronic ChD. The concentration and purity of DNA were evaluated in a Nanodrop Denovix DS-11FX Series Spectrophotometer (DeNovix Inc., Wilmington, NC, USA). The parasite load was determined with the Taqman® qPCR system using a Stratagene Mx3000P thermocycler (Agilent Technologies, Santa Clara, CA, USA) with Cruzi 1 and Cruzi 2 satellite primers. Student’s t-test with Bonferroni correction, Chi-squared (χ2) tests and Spearman’s correlation coefficient were applied. The concentration and purity of DNA were higher in the buffy coat. Parasite DNA was detected and quantifiable in the three types of samples in seven patients, without statistically significant differences in the parasite load obtained. Higher correlations were found between the total DNA concentrations and the parasite loads obtained in the samples of the buffy coat.
- Published
- 2024
- Full Text
- View/download PDF
24. Huexolotl: pasado y presente en México
- Author
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Scherrer, Carlos M. Varela
- Published
- 2022
- Full Text
- View/download PDF
25. Vertically Stacked CMOS-Compatible Photodiodes for Scanning Electron Microscopy.
- Author
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Lionel C. Gontard, Juan A. Leñero-Bardallo, Francisco M. Varela-Feria, and Ricardo Carmona-Galán
- Published
- 2020
- Full Text
- View/download PDF
26. Perfil de preferencias de aprendizaje de alumnos y profesores de medicina: Elemento a considerar en la enseñanza
- Author
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M.E. Ponce de León-Castañeda, M. Varela-Ruiz, J.R. Lozano-Sánchez, A. Ortiz-Montalvo, and R.E. Ponce-Rosas
- Subjects
Alumno ,Estilos de aprendizaje ,Profesor ,VARK ,Education (General) ,L7-991 ,Medicine (General) ,R5-920 - Abstract
Introducción. Es importante que alumnos y profesores comprendan y desarrollen habilidades que favorezcan un mejor aprendizaje. Para ello se debe identificar sus perfiles de aprendizaje. Sujetos y métodos. Con autorización del autor se aplicó el cuestionario VARK a 530 alumnos y 27 profesores del primer año de la carrera de Medicina en la Universidad Nacional Autónoma de México. Las respuestas al cuestionario se procesaron con la metodología establecida por el autor. Se utilizó la prueba exacta de Fisher para identificar diferencias entre ambos perfiles. Mediante análisis inferencial se buscó asociación por género y con el promedio de calificaciones, así como entre profesor y alumnos. Resultados. El 31% de alumnos presentó una modalidad, y el 69%, más de una; de éstos, el 14% desarrolló las cuatro modalidades. El 41% fueron visual/cinestésicos, y el 64% desarrolló una o dos modalidades. De los profesores, el 26% manifestó una modalidad, y el 74%, más de una; de ellos, el 4% tuvo las cuatro modalidades. No se encontraron diferencias estadísticamente significativas entre mujeres y hombres, ni entre los grupos matutinos, vespertinos o de alto rendimiento. Conclusiones. Este primer acercamiento permitió tener una visión general de las preferencias de aprendizaje de la población estudiada. Los resultados permitirán que cuando profesores y alumnos reconozcan su estilo de aprendizaje, podrán enriquecer su práctica docente y acercarla a las necesidades de sus alumnos, y con ello mejorar el proceso de enseñanza y los resultados del aprendizaje.
27. Stability and pKa Modulation of Aminophenoxazinones and Their Disulfide Mimics by Host–Guest Interaction with Cucurbit[7]uril. Direct Applications in Agrochemical Wheat Models
- Author
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Francisco J. R. Mejías, Suhang He, Rosa M. Varela, José M. G. Molinillo, Andrea Barba-Bon, Werner M. Nau, and Francisco A. Macías
- Subjects
General Chemistry ,General Agricultural and Biological Sciences - Published
- 2022
28. Automatable downstream purification of the benzohydroxamic acid D-DIBOA from a biocatalytic synthesis
- Author
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Maria Elena de la Calle, Gema Cabrera, Teresa Linares-Pineda, Domingo Cantero, José M.G. Molinillo, Rosa M. Varela, Antonio Valle, and Jorge Bolívar
- Subjects
Bioengineering ,General Medicine ,Molecular Biology ,Biotechnology - Abstract
Herbicides play a vital role in agriculture, contributing to increased crop productivity by minimizing weed growth, but their low degradability presents a threat to the environment and human health. Allelochemicals, such as DIBOA (2,4-dihydroxy-(2H)-1,4-benzoxazin-3(4 H)-one), are secondary metabolites released by certain plants that affect the survival or growth of other organisms. Although these metabolites have an attractive potential for use as herbicides, their low natural production is a critical hurdle. Previously, the synthesis of the biologically active analog D-DIBOA (4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one) was achieved, using an engineered E. coli strain as a whole-cell biocatalyst, capable of transforming a precursor compound into D-DIBOA and exporting it into the culture medium, although it cannot be directly applied to crops. Here a chromatographic method to purify D-DIBOA from this cell culture medium without producing organic solvent wastes is described. The purification of D-DIBOA from a filtered culture medium to the pure compound could also be automated. Biological tests with the purified compound on weed models showed that it has virtually the same activity than the chemically synthesized D-DIBOA.
- Published
- 2022
29. IGMM-Based Approach for Discovering Co-Located Mobile Users.
- Author
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Pedro M. Varela, Jihoon Hong, and Tomoaki Ohtsuki
- Published
- 2016
- Full Text
- View/download PDF
30. Evaluación de los planes de contingencia en la atención a pacientes en Unidades de Cuidados Intensivos en la pandemia por COVID-19
- Author
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M. Martínez-Pillado, I. Said-Criado, A. Regueiro-Martínez, M. Varela-Durán, D. Baltar Boileve, O. Solas Gaspar, A. Pazos-Sierra, E. Varela-Álvarez, and O. Briones-Gamarra
- Subjects
Health Policy - Published
- 2022
31. Entre Electra y Mariucha. La poética compensatoria del Galdós moderado
- Author
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M Varela Olea
- Subjects
General Engineering - Published
- 2022
32. Synthesis of Benzoxazinones Sulphur Analogs and Their Application as Bioherbicides: 1.4-Benzothiazinones and 1.4-Benzoxathianones for Weed Control
- Author
-
Macías, Francisco J. R. Mejías, Stefan Schwaiger, Rosa M. Varela, José M. G. Molinillo, Nuria Chinchilla, and Francisco A.
- Subjects
benzothiazinones ,bioassay ,weeds ,allelopathy ,docking - Abstract
Eight different compounds inspired by benzoxazinones were synthesized in one simple step with easy purification. These compounds have a sulfur atom instead of the oxygen atom present in benzoxazinones. Furthermore, a new derivative obtained by a Rutkauskas–Beresnevicius reaction was synthesized. These compounds were evaluated in vitro to assess their phytotoxicity in plant cells by the elongation of wheat coleoptiles. The novel compounds showed higher inhibition than benzoxazinones and the positive control, especially at higher concentrations (1000 and 300 μM). Benzoxazinones have been described as histidine deacetylase inhibitors and we therefore evaluated the effect of 1.4-benzothiazinones and 1.4-benzoxathianones against HDA6, one of the most important enzymes of the family, in silico by molecular docking and molecular dynamics. In vitro studies against Echinochloa crus-galli, Lolium rigidum and Portulaca oleracea weeds gave interesting results against the growth of the roots for both monocots and dicots. Specifically, the inhibition was more pronounced against dicots, as in the case of common purslane, whose inhibition at a concentration of 1000 μM was similar to that of the classical herbicide employed as a positive control. Higher inhibition was obtained when an aliphatic group was present in the C2 position of 1.4-benzothiazinones.
- Published
- 2023
- Full Text
- View/download PDF
33. Commodified Communion: Eucharist, Consumer Culture, and the Practice of Everyday Life. By Antonio Eduardo Alonso. New York: Fordham University Press, 2021. 188 pages. $28.00 (paper)
- Author
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Héctor M. Varela Rios
- Subjects
Religious studies ,Education - Published
- 2022
34. Evaluation of the phytotoxic and antifungal activity of <scp> C 17 </scp> ‐sesquiterpenoids as potential biopesticides
- Author
-
David M. Cárdenas, Joanna Bajsa‐Hirschel, Charles L. Cantrell, Carlos Rial, Rosa M. Varela, José M. G. Molinillo, and Francisco A. Macías
- Subjects
Insect Science ,General Medicine ,Agronomy and Crop Science - Published
- 2022
35. Abstract 830: Optimized retinoblastoma treatment approach using a Y79 retinoblastoma cellular model and CCK-8 in vitro assay protocol
- Author
-
Martinez, Ashley M. Varela, primary, Kim, Hae Chan, additional, Goli, Naga, additional, and Campbell, Robert, additional
- Published
- 2023
- Full Text
- View/download PDF
36. Modelling Senescence In Osteoarthritis: Combining Irradiation And Mechanical Loading In Human Osteochondral Explants
- Author
-
Boone, I., primary, van den Berg, J.J., additional, Eirin, M. Varela, additional, Tuerlings, M., additional, Houtman, E., additional, Demaria, M., additional, and Meulenbelt, I., additional
- Published
- 2023
- Full Text
- View/download PDF
37. A multi-technique study for the spectroscopic characterization of the ceramics from Santa Maria do Castelo church (Torres Novas, Portugal)
- Author
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Ferreira, L.F. Vieira, Gomes, M. Varela, Pereira, M.F.C., Santos, L.F., and Machado, I. Ferreira
- Published
- 2016
- Full Text
- View/download PDF
38. Thermophysical properties of n-alkyl-ammonium nitrate ionic liquids (n = 2,3,4) pure and water saturated for energy applications
- Author
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J. J. Parajó, P. Vallet, M. J. G. Guimarey, A. Santiago, T. Teijera, A. Amigo, L. M. Varela, J. Salgado, and M. Villanueva
- Subjects
Physical and Theoretical Chemistry ,Condensed Matter Physics - Abstract
Phase transition temperatures of three ionic liquids (ILs) with ammonium cations of different alkyl chain length and nitrate common anion were determined in this paper by differential scanning calorimetry. Thermal stability of these ILs in air and nitrogen atmosphere and the maximum operation temperatures of the compounds were also studied using a thermogravimetric analyser. Furthermore, thermophysical properties as density, viscosity, thermal conductivity, and heat capacity against temperature of these pure ionic liquids were determined and compared with the corresponding values for water saturated samples. For this purpose, different techniques were employed: for density and viscosity a rotational automated viscodensimeter; for thermal conductivity measurements a thermal conductimeter that follows the transient hot-wire method; and for heat capacity measurements a microdifferential scanning calorimeter. Different behaviours were observed depending on the analysed thermophysical properties. In case of dried samples, density and thermal conductivity decrease with alkyl chain; for saturated samples, same tendency is observed for density but is the opposite in case of thermal conductivity. Isobaric specific heat and viscosity increase with alkyl chain length in case of dried samples; for saturated samples same tendency is observed for the viscosity, whereas the tendency is the contrary in case of isobaric specific heat.
- Published
- 2023
39. Morphological variation in the mandible of white males and females from the East Texas region for potential applications for skeletal identification
- Author
-
Lissette M. Varela, Benjamin H. Moss, and Peer Moore-Jansen
- Subjects
Pathology and Forensic Medicine - Published
- 2022
40. Study on the Feasibility of Using Low-Cost Techniques and Tools to Manufacture a Scale Model of a Ship for Maneuvering Experiments
- Author
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J. M. Varela and C. Guedes Soares
- Subjects
Mechanical Engineering ,Ocean Engineering - Abstract
This article studies the feasibility of using low-cost materials, techniques, and tools to manufacture a 1/100-scale model of a VLCC. For this purpose, three main aspects were considered to reduce the production costs: 1) the bypass to the fabrication of a mold, by building directly the final hull with mid-density fiber wood; 2) the use of a 3 degrees of freedom computer numerical control (CNC) milling machine to cut and shape the pieces of the hull, which can be easily rented at affordable prices; 3) the automation as much as possible of the process to avoid contracting highly skilled personnel to do manual tasks, which would increase substantially the fabrication costs. The article is based on the practical case study of the fabrication of the KVLCC2 (KRISO Very Large Crude Carrier 2) scale model, which is used to describe the digital models, the milling process, and the finishing work. At the end, the validation of the model is done by comparing the final physical hull surface with the original digital one. This study is mainly directed to small maritime research centers and/or universities, which are interested in performing maneuvering experiments with homemade ship scale models.
- Published
- 2022
41. 'Depicting Heavenly Reality': Non-Textual Objects as Inscriptions of Belief
- Author
-
Héctor M. Varela Rios
- Subjects
Religious studies - Published
- 2022
42. Return to Teamsterville: A reconsideration and dialogue on ethnography and critique
- Author
-
Mark Ward, Leland G. Spencer, Craig O. Stewart, and Elisa M. Varela
- Subjects
Communication - Published
- 2022
43. The role of intrasexual competition on the evolution of male-male courtship display : a systematic review
- Author
-
Inês Órfão, Constança Carvalho, Inês Rodrigues, Leonor Ascensão, Marie Pedaccini, Luís Vicente, Miguel Barbosa, Susana A. M. Varela, European Research Council, and University of St Andrews. School of Biology
- Subjects
MCC ,Sexual information ,QL ,General Neuroscience ,QH301 Biology ,DAS ,General Medicine ,Sexual signals' dual function ,QL Zoology ,Intrasexual selection ,General Biochemistry, Genetics and Molecular Biology ,AC ,QH301 ,Sexual selection ,Social information ,Communication network ,Display ,Trait co-option ,General Agricultural and Biological Sciences - Abstract
Funding: This work was supported by the Portuguese National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within: I&D units grants CFCUL—Centro de Filosofia das Ciências da Universidade de Lisboa (grant numbers FCT I.P.: UIDB/00678/2020 e UIDP/00678/2) and cE3c—Centre for Ecology, Evolution and Environmental Changes (grant number FCT I.P.: UID/BIA/00329/2013), and within Inês Órfão’s PhD grant (grant number SFRH/BD/90686/2012), and the Post-Doctoral research grants of Miguel Barbosa (grant number SFRH/BPD/82259/2011) and Susana AM Varela (grant number SFRH/BPD/66042/2009). Inês Órfão received financial support from ARDITI (M1420-09-5369-FSE-000002) and Miguel Barbosa received financial support from CESAM (UIDP/50017/2020þUIDB/50017/2020). This work was also supported by the European Research Council (ERC) within the project BioTIME (ERC grant number 250189). Background Evidence of male-male courtship display is widespread across the animal kingdom. Yet, its function and evolutionary origin remain unclear. Here, we hypothesise that male-male courtship display evolved in response to selection pressure exerted by intrasexual competition during male-female courtship interactions. Intrasexual competition can be caused by bystander male pressure through eavesdropping and exploiting on displayer male’s courtship interactions with females. This bystander pressure can lead to an audience effect by the displayer, who will change their courtship behaviour in the presence of bystanders and display directly towards them, even in the absence of females, as an intimidation strategy. In species where this selection pressure has taken place, we predict that the male courtship display will have a dual function: attract females and deter competitors. Therefore, we expected to find more evidence of bystander-related behaviours in species for which male-male courtship display is linked to intrasexual competition compared to species for which other explanatory hypotheses are more plausible (e.g., mistaken identity or courtship practice). Methodology We conducted two systematic reviews to test this hypothesis. First, we conducted a search for studies of species with courtship display between males and of the hypotheses provided to explain this behaviour. Our goal was to identify the species with male-male courtship display and evidence of intrasexual competition. Second, among the species with male-male courtship display, we searched for evidence of bystander-related behaviours, i.e., articles referring to eavesdropping, exploitation, and audience effect during male-female courtship interactions. Our goal was to test whether species with intrasexual competition are also more likely to show bystander-related behaviours. Results Although most studies reporting male courtship display towards other males do not suggest any explanatory hypothesis for this behaviour, the intrasexual competition hypothesis was largely mentioned and supported by some studies reviewed. Additionally, there is more evidence of eavesdropping and of all three bystander-related behaviours combined in species for which the intrasexual competition hypothesis was suggested. Conclusions Overall, our review supports the hypothesis that intrasexual competition can play a key role in male courtship display evolution, namely that male-male courtship display may have evolved as a secondary function of male-female courtship interactions via bystander male pressure. However, our review also shows that despite the increasing interest in same-sex sexual behaviours, and male-male courtship display in particular, most studies were found to be merely descriptive, and the hypotheses they suggested to explain courtship display between males mostly speculative. This highlights an important gap in the literature. To clarify both the evolution and the function of male-male courtship display, this behaviour needs to be empirically studied more often. Our review can help advancing this research area, as it makes the 20 species with male-male courtship display for which the intrasexual competition hypothesis was suggested excellent candidates for empirical research. Publisher PDF
- Published
- 2023
44. Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV
- Author
-
Juliana M. Tatara, Rafael L. Rosa, Ana Paula M. Varela, Tais F. Teixeira, Patrícia Sesterheim, Anderson Gris, David Driemeier, Amanda N. S. Moraes, Markus Berger, Ramon D. Peña, Paulo M. Roehe, Diogo O. G. Souza, Jorge A. Guimarães, Alexandre R. Campos, Lucélia Santi, and Walter O. Beys-da-Silva
- Subjects
Virology ,General Medicine - Published
- 2023
45. Stability and p
- Author
-
Francisco J R, Mejías, Suhang, He, Rosa M, Varela, José M G, Molinillo, Andrea, Barba-Bon, Werner M, Nau, and Francisco A, Macías
- Abstract
Aqueous solubility and stability often limit the application of aminophenoxazinones and their sulfur mimics as promising agrochemicals in a sustainable agriculture inspired by allelopathy. This paper presents a solution to the problem using host-guest complexation with cucurbiturils (
- Published
- 2022
46. Evolution of the spontaneous sourdoughs microbiota prepared with organic or conventional whole wheat flours from South Brazil
- Author
-
LETÍCIA F.X. COSTA, CAROLINE ISABEL KOTHE, TIELA T. GRASSOTTI, RAQUEL P. GARSKE, BEATRIZ N. SANDOVAL, ANA PAULA M. VARELA, JANIRA PRICHULA, JEVERSON FRAZZON, MICHELE B. MANN, ROBERTA C.S. THYS, and ANA PAULA G. FRAZZON
- Subjects
lactic acid bacteria ,Issatchenkia orientalis ,Multidisciplinary ,sourdough ,microbial communities ,acetic acid bacteria ,wheat flour - Abstract
The purpose of this study was to compare the composition and stability of bacteria and fungi communities during the propagation of sourdoughs prepared with organic or conventional whole wheat (Triticum aestivum) flours from South Brazil. Sourdoughs were prepared and samples were collected during different fermentation times (0 to 216 h). Total DNA of sourdough samples were extracted and the 16S rRNA gene and Internal Transcribed Spacer region were sequenced by MiSeq-Illumina. A total of 43 and 56 OTUs were identified and defined as core taxa in the bacterial and fungal communities, respectively. The analysis revealed increases in the relative abundances of the lactic acid (Pediococcus pentosaceus, Weissella hellenica and Limosilactobacillus pontis) and acetic acid bacteria (Gluconobacter frateurii and Acetobacter tropicalis) during the sourdough propagation. The filaments fungi, Alternaria tenuissima, Fusarium culmorum, Fusarium petersiae and Microdochium seminicola remained more stable in organic than conventional during propagation cycles. After 216 h of fermentation, both sourdoughs were dominated by acid- and salt-tolerant yeast Issatchenkia orientalis (syn Pichia kudriavzevii, and Candida glycerinogenes). In conclusion, there were no significant differences in microbial communities among the sourdough samples. This study revealed that both flours contain autochthonous LAB, AAB, and yeasts with biotechnological applications in sourdough bread-making.
- Published
- 2022
47. Zooplankton-derived dissolved organic matter composition and its bioavailability of natural prokaryotic communities
- Author
-
Daniele De Corte, Marta M. Varela, Angeles M. Louro, Sarah K. Bercovici, Joaquín Valencia‐Vila, Eva Sintes, Federico Baltar, Tamara Rodríguez‐Ramos, Meinhard Simon, Antonio Bode, Thorsten Dittmar, and Jutta Niggemann
- Subjects
zooplankton ,marine environment ,limnology ,Dissolved organic matter ,Aquatic Science ,Oceanography ,bioavailability ,prokaryotic communities ,organic matter - Abstract
Research article, Zooplankton grazing onphytoplankton promotes the release of particulate and dissolved organic matter (DOM) into the water column and therefore plays a key role in organic matter cycling in aquatic systems. Prokaryotes are the main DOM consumers in the ocean by actively remineralizing and transforming it, contributing to its molecular diversification. To explore the molecular composition of zooplankton-derived DOM and its bioavailability to natural prokaryotic communities, the DOM generated by a mixed zooplankton community in the coastal Atlantic off Spain was used as substrate for a natural prokaryotic community and monitored over a ~ 5-d incubation experiment. The molecular composition of solid-phase extracted DOM was characterized via Fourier-transform ion cyclotron resonance mass spectrometry. After ~ 4 d in the zooplankton-derived DOM amended incubation, the prokaryotic community demonstrated a 17-fold exponential increase in cell number. The prokaryotic growth resulted in a reduction in bulk dissolved organic carbon concentration and the zooplankton-derived DOM was considerably transformed at molecular and bulk elemental levels over the incubation period. The C : N ratio (calculated from the obtained molecular formulae) increased while the functional diversity decreased over the incubation time. In addition, molecular indices pointed to a reduced bioavailability of DOM at the end of the experiment. These findings show that zooplankton excreta are a source of labile organic matter that is quickly metabolized by the prokaryotic community. Therefore, a fraction of carbon is shunted from transfer to secondary consumers similarly to the viral shunt, suggesting that the zooplankton–prokaryotic interactions play an important role in the ocean's carbon cycle., IEO, XUNTA DE GALICIA (INGO7A 2018/2), DFG (CO 2218/2-1 and TRR51)
- Published
- 2022
48. New Therapeutic Peptides To Target Senescence In Osteoarthritis
- Author
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M. Varela-Eirín, I. López-Díaz, P. Carpintero-Fernández, A. Sánchez-Temprano, A. García-Yuste, S. Learte-Aymamí, E. Pazos, J.L. Mascareñas, M.E. Vázquez, and J.R. Caeiro
- Subjects
Rheumatology ,Biomedical Engineering ,Orthopedics and Sports Medicine - Published
- 2023
49. Modelling Senescence In Osteoarthritis: Combining Irradiation And Mechanical Loading In Human Osteochondral Explants
- Author
-
I. Boone, J.J. van den Berg, M. Varela Eirin, M. Tuerlings, E. Houtman, M. Demaria, and I. Meulenbelt
- Subjects
Rheumatology ,Biomedical Engineering ,Orthopedics and Sports Medicine - Published
- 2023
50. Role Of Connexin43 And Purinergic Signaling In Modulating Cellular Senescence In Osteoarthritis
- Author
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M. Varela-Eirin, J. Nehme, M. Mayan, and M. Demaria
- Subjects
Rheumatology ,Biomedical Engineering ,Orthopedics and Sports Medicine - Published
- 2023
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