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Mespilus germanica L., commonly known as medlar, is one of two species of the Rosaceae family. The medlar plant has a long history of use in gastronomy and healthcare. Medlar waste is used to extract hazardous heavy metals from contaminated water. The nutritional value of M. germanica fruits comes from their composition of carbohydrates, carotenoids, amino acids, organic acids, proteins, vitamins, fatty acids, and vital components. M. germanica fruit contains a high concentration of important phenolic components, which contribute to its anti-diabetic and antioxidant properties. Additionally, several studies have identified diverse biological properties of the M. germanica plant, including the cytotoxic, neurodegenerative, and antibacterial properties of its fruits and leaves. Scientists are investigating underutilized plant species to address sustainability issues in food production. This review study will provide a comprehensive examination of its chemical composition, medical applications, plant waste utilization, and potential biological activities.