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4 results on '"M.A. Wolff"'

1. The Melanocytotoxic Action of 4-Hydroxyanisole

Author

B. C. Sawyer, M.A. Wolff, and P.A. Riley

Subjects
Erythrocytes, Lysis, Molar concentration, Tyrosinase, Guinea Pigs, Ascorbic Acid, Dermatology, Anisoles, Biology, Biochemistry, Antioxidants, Increased lipid, medicine, Animals, Humans, Vitamin E, Cytotoxicity, Cell damage, Molecular Biology, Aldehydes, Dose-Response Relationship, Drug, Substrate (chemistry), 4-hydroxyanisole, Cell Biology, medicine.disease, Glutathione, Malonates, Rats, Microsomes, Liver, Melanocytes, Oxidation-Reduction, Catechol Oxidase
Abstract

Cultured normal mammalian melanocytes exposed to a variety of antioxidants in the presence of millimolar concentrations of 4-hydroxyanisole exhibit dose-dependent modifications of cytotoxicity. While some antioxidants reduced the extent of damage produced by 4-hydroxyanisole, others appeared to increase it. Similar effects were found in a model system using lysis of human erythrocytes as an index of cell damage. Estimations on rat liver microsomes in the presence of tyrosinase and 4-hydroxyanisole showed increased lipid peroxidation only at low substrate concentrations.

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2. Validation of NO2 and NO from the Atmospheric Chemistry Experiment (ACE)

Author

Kerzenmacher, T., Wolff, M. A., Strong, K., Dupuy, E., Walker, K. A., Amekudzi, L. K., Batchelor, R. L., Bernath, P. F., Berthet, G., Blumenstock, T., Boone, C. D., Bramstedt, K., Brogniez, C., Brohede, S., Burrows, J. P., Valéry CATOIRE, Dodion, J., Drummond, J. R., Dufour, D. G., Funke, B., Fussen, D., Goutail, F., Griffith, D. W. T., Haley, C. S., Hendrick, F., Hoepfner, M., Huret, N., Jones, N., Kar, J., Kramer, I., Llewellyn, E. J., Lopez-Puertas, M., Manney, G., Mcelroy, C. T., Mclinden, C. A., Melo, S., Mikuteit, S., Murtagh, D., Nichitiu, F., Notholt, J., Nowlan, C., Piccolo, C., Pommereau, J. -P, Randall, C., Raspollini, P., Ridolfi, M., Richter, A., Schneider, M., Schrems, O., Silicani, M., Stiller, G. P., Taylor, J., Tetard, C., Toohey, M., Vanhellemont, F., Warneke, T., Zawodny, J. M., Zou, J., Department of Physics [Toronto], University of Toronto, Department of Chemistry [Waterloo], University of Waterloo [Waterloo], Institute of Environmental Physics [Bremen] (IUP), University of Bremen, Department of Chemistry [York, UK], University of York [York, UK], Laboratoire de physique et chimie de l'environnement (LPCE), Université d'Orléans (UO)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut für Meteorologie und Klimaforschung - Atmosphärische Umweltforschung (IMK-IFU), Karlsruher Institut für Technologie (KIT), Laboratoire d’Optique Atmosphérique - UMR 8518 (LOA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Radio and Space Science [Göteborg], Chalmers University of Technology [Göteborg], Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique (BIRA-IASB), Department of Physics and Atmospheric Science [Halifax], Dalhousie University [Halifax], Picomole Instruments Inc., Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Service d'aéronomie (SA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Wollongong [Australia], Centre for Research in Earth and Space Science [Toronto] (CRESS), York University [Toronto], Institute of Space and Atmospheric Studies [Saskatoon] (ISAS), Department of Physics and Engineering Physics [Saskatoon], University of Saskatchewan [Saskatoon] (U of S)-University of Saskatchewan [Saskatoon] (U of S), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), New Mexico Institute of Mining and Technology [New Mexico Tech] (NMT), Environment and Climate Change Canada, Canadian Space Agency (CSA), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), University of Oxford [Oxford], Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], Istituto di Fisica Applicata 'Nello Carrara' (IFAC), Consiglio Nazionale delle Ricerche [Roma] (CNR), Dipartimento di Chimica Fisica ed Inorganica, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), NASA Langley Research Center [Hampton] (LaRC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Wollongong, Università di Bologna [Bologna] (UNIBO), Institute of Environmental Physics [Bremen] ( IUP ), Laboratoire de physique et chimie de l'environnement ( LPCE ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Institut für Meteorologie und Klimaforschung - Atmosphärische Umweltforschung ( IMK-IFU ), Karlsruher Institut für Technologie ( KIT ), Laboratoire d’Optique Atmosphérique - UMR 8518 ( LOA ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique ( BIRA-IASB ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Service d'aéronomie ( SA ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Centre for Research in Earth and Space Science [Toronto] ( CRESS ), Institute of Space and Atmospheric Studies [Saskatoon] ( ISAS ), University of Saskatchewan [Saskatoon] ( U of S ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), New Mexico Institute of Mining and Technology [New Mexico Tech] ( NMT ), Canadian Space Agency ( CSA ), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] ( AOPP ), Laboratory for Atmospheric and Space Physics [Boulder] ( LASP ), University of Colorado Boulder [Boulder], Istituto di Fisica Applicata 'Nello Carrara' ( IFAC ), Consiglio Nazionale delle Ricerche [Roma] ( CNR ), Università di Bologna [Bologna] ( UNIBO ), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung ( AWI ), NASA Langley Research Center [Hampton] ( LaRC ), Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), University of Oxford, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), T. Kerzenmacher, M.A. Wolff, K. Strong, E. Dupuy, K.A. Walker, L.K. Amekudzi, R.L. Batchelor, P.F. Bernath, G. Berthet, T. Blumenstock, C.D. Boone, K. Bramstedt, C. Brogniez, S. Brohede, J.P. Burrow, V. Catoire, J. Dodion, J.R. Drummond, D.G. Dufour, B. Funke, D. Fussen, F. Goutail, D.W.T. Griffith, C.S. Haley, F. Hendrick, M. H\'opfner, N. Huret, N. Jone, J. Kar, I. Kramer, E.J. Llewellyn, M. Lopez-Puerta, G. Manney, C.T. McElroy, C.A. McLinden, S. Melo, S. Mikuteit, D. Murtagh, F. Nichitiu, J. Notholt, C. Nowlan, C. Piccolo, J.-P. Pommereau, C. Randall, P. Raspollini, M. Ridolfi, A. Richter, M. Schneider, O. Schrem, M. Silicani, G.P. Stiller, J. Taylor, C. Tetard, M. Toohey, F. Vanhellemont, T. Warneke, J.M. Zawodny, and J. Zou

Subjects
[PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], [ PHYS.PHYS.PHYS-AO-PH ] Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]
Abstract

International audience; Vertical profiles of NO2 and NO have been obtained from solar occultation measurements by the Atmospheric Chemistry Experiment (ACE), using an infrared Fourier Transform Spectrometer (ACE-FTS) and (for NO2) an ultraviolet-visible-near-infrared spectrometer, MAESTRO (Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation). In this paper, the quality of the ACE-FTS version 2.2 NO2 and NO and the MAESTRO version 1.2 NO2 data are assessed using other solar occultation measurements (HALOE, SAGE II, SAGE III, POAM III, SCIAMACHY), stellar occultation measurements (GOMOS), limb measurements (MIPAS, OSIRIS), nadir measurements (SCIAMACHY), balloon-borne measurements (SPIRALE, SAOZ) and ground-based measurements (UV-VIS, FTIR). Time differences between the comparison measurements were reduced using either a tight coincidence criterion, or where possible, chemical box models. ACE-FTS NO2 and NO and the MAESTRO NO2 are generally consistent with the correlative data. The ACE-FTS and MAESTRO NO2 volume mixing ratio (VMR) profiles agree with the profiles from other satellite data sets to within about 20% between 25 and 40 km, with the exception of MIPAS ESA (for ACE-FTS) and SAGE II (for ACE-FTS (sunrise) and MAESTRO) and suggest a negative bias between 23 and 40 km of about 10%. MAESTRO reports larger VMR values than the ACE-FTS. In comparisons with HALOE, ACE-FTS NO VMRs typically (on average) agree to ±8% from 22 to 64 km and to +10% from 93 to 105 km, with maxima of 21% and 36%, respectively. Partial column comparisons for NO2 show that there is quite good agreement between the ACE instruments and the FTIRs, with a mean difference of +7.3% for ACE-FTS and +12.8% for MAESTRO.

Published
2008
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3. Validation of HNO3, ClONO2, and N2O5 from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS)

Author

M. A. Wolff, T. Kerzenmacher, K. Strong, K. A. Walker, M. Toohey, E. Dupuy, P. F. Bernath, C. D. Boone, S. Brohede, V. Catoire, T. von Clarmann, M. Coffey, W. H. Daffer, M. De Maziere, P. Duchatelet, N. Glatthor, D. W. T. Griffith, J. Hannigan, F. Hase, M. Hoepfner, N. Huret, N. Jones, K. Jucks, A. Kagawa, Y. Kasai, I. Kramer, H. Kullmann, J. Kuttippurath, E. Mahieu, G. Manney, C. McLinden, Y. Mebarki, S. Mikuteit, D. Murtagh, C. Piccolo, P. Raspollini, R. Ruhnke, M. Santee, C. Senten, D. Smale, C. Tetard, J. Urban, S. Wood, RIDOLFI, MARCO, M.A. Wolff, T. Kerzenmacher, K. Strong, K.A. Walker, M. Toohey, E. Dupuy, P.F. Bernath, C.D. Boone, S. Brohede, V. Catoire, T. von Clarmann, M. Coffey, W.H. Daffer, M. De Maziere, P. Duchatelet, N.Glatthor, D.W.T. Griffith, J. Hannigan, F. Hase, M. Hoepfner, N. Huret, N. Jone, K. Juck, A. Kagawa, Y. Kasai, I. Kramer, H. Kullmann, J. Kuttippurath, E. Mahieu, G. Manney, C. McLinden, Y. Mebarki, S. Mikuteit, D. Murtagh, C. Piccolo, P. Raspollini, M. Ridolfi, R. Ruhnke, M. Santee, C. Senten, D. Smale, C. Tetard, J. Urban, and S.Wood

Published
2008

4. Validation of ACE-FTS N2O measurements

Author

Strong, K., Wolff, M. A., Kerzenmacher, T. E., Walker, K. A., Bernath, P. F., Blumenstock, T., Boone, C., Valéry CATOIRE, Coffey, M., Maziere, M., Demoulin, P., Duchatelet, P., Dupuy, E., Hannigan, J., Hoepfner, M., Glatthor, N., Griffith, D. W. T., Jin, J. J., Jones, N., Jucks, K., Kuellmann, H., Kuttippurath, J., Lambert, A., Mahieu, E., Mcconnell, J. C., Mellqvist, J., Mikuteit, S., Murtagh, D. P., Notholt, J., Piccolo, C., Raspollini, P., Ridolfi, M., Robert, C., Schneider, M., Schrems, O., Semeniuk, K., Senten, C., Stiller, G. P., Strandberg, A., Taylor, J., Tetard, C., Toohey, M., Urban, J., Warneke, T., Wood, S., K. Strong, M.A. Wolff, T.E. Kerzenmacher, K.A. Walker, P.F. Bernath, T. Blumenstock, C. Boone, V. Catoire, M. Coffey, M. De Mazi\`ere, P. Demoulin, P. Duchatelet, E. Dupuy, J. Hannigan, M. H\'opfner, N. Glatthor, D.W.T. Griffith, J.J. Jin, N. Jone, K. Juck, H. Kuellmann, J. Kuttippurath, A. Lambert, E. Mahieu, J.C. McConnell, J. Mellqvist, S. Mikuteit, D.P. Murtagh, J. Notholt, C. Piccolo, P. Raspollini, M. Ridolfi, C. Robert, M. Schneider, O. Schrem, K. Semeniuk, C. Senten, G.P. Stiller, A. Strandberg, J. Taylor, C. Tétard, M. Toohey, J. Urban, T. Warneke, and S. Wood

Subjects
lcsh:Chemistry, lcsh:QD1-999, lcsh:Physics, lcsh:QC1-999
Abstract

The Atmospheric Chemistry Experiment (ACE), also known as SCISAT, was launched on 12 August 2003, carrying two instruments that measure vertical profiles of atmospheric constituents using the solar occultation technique. One of these instruments, the ACE Fourier Transform Spectrometer (ACE-FTS), is measuring volume mixing ratio (VMR) profiles of nitrous oxide (N2O) from the upper troposphere to the lower mesosphere at a vertical resolution of about 3–4 km. In this study, the quality of the ACE-FTS version 2.2 N2O data is assessed through comparisons with coincident measurements made by other satellite, balloon-borne, aircraft, and ground-based instruments. These consist of vertical profile comparisons with the SMR, MLS, and MIPAS satellite instruments, multiple aircraft flights of ASUR, and single balloon flights of SPIRALE and FIRS-2, and partial column comparisons with a network of ground-based Fourier Transform InfraRed spectrometers (FTIRs). Between 6 and 30 km, the mean absolute differences for the satellite comparisons lie between −42 ppbv and +17 ppbv, with most within ±20 ppbv. This corresponds to relative deviations from the mean that are within ±15%, except for comparisons with MIPAS near 30 km, for which they are as large as 22.5%. Between 18 and 30 km, the mean absolute differences for the satellite comparisons are generally within ±10 ppbv. From 30 to 60 km, the mean absolute differences are within ±4 ppbv, and are mostly between −2 and +1 ppbv. Given the small N2O VMR in this region, the relative deviations from the mean are therefore large at these altitudes, with most suggesting a negative bias in the ACE-FTS data between 30 and 50 km. In the comparisons with the FTIRs, the mean relative differences between the ACE-FTS and FTIR partial columns (which cover a mean altitude range of 14 to 27 km) are within ±5.6% for eleven of the twelve contributing stations. This mean relative difference is negative at ten stations, suggesting a small negative bias in the ACE-FTS partial columns over the altitude regions compared. Excellent correlation (R=0.964) is observed between the ACE-FTS and FTIR partial columns, with a slope of 1.01 and an intercept of −0.20 on the line fitted to the data.

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