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3 results on '"M.C. Perier"'

1. Long-term follow-up of cardiac arrest survivors: Protocol of the DESAC (Devenir des survivants d’Arrets Cardiaques) study, a French multicentric prospective cohort

Author

F. Dumas, W. Bougouin, M.C. Perier, N. Marin, C. Goulenok, A. Vieillard-Baron, J.L. Diehl, S. Legriel, N. Deye, P. Cronier, S. Ricôme, F. Chemouni, A. Mekontso Dessap, F. Beganton, E. Marijon, X. Jouven, J.P. Empana, and A. Cariou

Subjects
Cardiac arrest, Long-term outcome, Coronary angiogram, Targeted temperature management, Specialties of internal medicine, RC581-951
Abstract

Background: While the short-term prognosis of cardiac arrest patients - nearly 250,000 new cases per year in Europe - has been extensively studied, less is known regarding the mid and long-term outcome of survivors. Objective: The aim of the DESAC study is to describe mid- and long-term survival rate and functional status of cardiac arrest survivors, and to assess the influence of pre and intra hospital therapeutic strategies on these two outcomes. Methods: Between Jul 2015 and Oct 2018, adult patients over 18 years who were discharged alive from any intensive care units (public and private hospitals) in the Ile-de-France area (Paris and suburbs, France) after a non-traumatic cardiac arrest were screened for participation in this multicentric study. Survivors were included after they signed (or the proxies) an informed consent before discharge during initial hospitalisation. We calculated that including 600 patients in total would allow an 80% power to demonstrate a 2 years survival rate difference of 10% between patients who did and those who did not receive therapeutic hypothermia after resuscitation. Pre- and in-hospital data related to the circumstances surrounding the event and to the therapeutic interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective therapeutics) were collected. After discharge, patients were interviewed at 3 months, 6 months and every year thereafter for a minimum follow-up of 26 months and a maximum follow-up of 48 months. Information on vital status, occurrence of cardiovascular events, medications and a comprehensive assessment of the functional status (qualitive of life as assessed by the Short-Form General Health Survey (SF36) scale, activities of daily living (ADL) scale, neurological Cerebral Performance Categories (CPC) and Overall Performance Categories (OPC) scales, socio-professional activities) were collected at follow-up interviews. Discussion: The DESAC study should provide important information regarding several dimensions of the mid and long-term prognosis of cardiac arrest survivors and on the benefit (and potentially harm) of early therapeutic strategies.

Published
2023
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2. Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness

Author

Jean Baptiste Lascarrou, Florence Dumas, Wulfran Bougouin, Stephane Legriel, Nadia Aissaoui, Nicolas Deye, Frankie Beganton, Lionel Lamhaut, Daniel Jost, Antoine Vieillard-Baron, Graham Nichol, Eloi Marijon, Xavier Jouven, Alain Cariou, F. Adnet, J.M. Agostinucci, N. Aissaoui-Balanant, V. Algalarrondo, F. Alla, C. Alonso, W. Amara, D. Annane, C. Antoine, P. Aubry, E. Azoulay, F. Beganton, C. Billon, W. Bougouin, J. Boutet, C. Bruel, P. Bruneval, A. Cariou, P. Carli, E. Casalino, C. Cerf, A. Chaib, B. Cholley, Y. Cohen, A. Combes, J.M. Coulaud, D. Da Silva, V. Das, A. Demoule, I. Denjoy, N. Deye, J.L. Diehl, S. Dinanian, L. Domanski, D. Dreyfuss, J.L. Dubois-Rande, F. Dumas, J. Duranteau, J.P. Empana, F. Extramiana, J.Y. Fagon, M. Fartoukh, F. Fieux, E. Gandjbakhch, G. Geri, B. Guidet, F. Halimi, P. Henry, P. Jabre, L. Joseph, D. Jost, X. Jouven, N. Karam, J. Lacotte, K. Lahlou-Laforet, L. Lamhaut, A. Lanceleur, O. Langeron, T. Lavergne, E. Lecarpentier, A. Leenhardt, N. Lellouche, V. Lemiale, F. Lemoine, F. Linval, T. Loeb, B. Ludes, C.E. Luyt, N. Mansencal, N. Mansouri, E. Marijon, E. Maury, V. Maxime, B. Megarbane, A. Mekontso-Dessap, H. Mentec, J.P. Mira, X. Monnet, K. Narayanan, N. Ngoyi, M.C. Perier, O. Piot, P. Plaisance, B. Plaud, I. Plu, J.H. Raphalen, M. Raux, F. Revaux, J.D. Ricard, C. Richard, B. Riou, F. Roussin, F. Santoli, F. Schortgen, T. Sharshar, G. Sideris, C. Spaulding, J.L. Teboul, J.F. Timsit, J.P. Tourtier, P. Tuppin, C. Ursat, O. Varenne, A. Vieillard-Baron, S. Voicu, K. Wahbi, and V. Waldmann

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2023
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3. Should We Perform an Immediate Coronary Angiogram in All Patients After Cardiac Arrest?

Author

Wulfran Bougouin, Florence Dumas, Nicole Karam, Carole Maupain, Eloi Marijon, Lionel Lamhaut, Daniel Jost, Guillaume Geri, Frankie Beganton, Olivier Varenne, Christian Spaulding, Xavier Jouven, Alain Cariou, F. Adnet, J.M. Agostinucci, N. Aissaoui-Balanant, J. Albuisson, V. Algalarrondo, F. Alla, D. Annane, C. Antoine, P. Aubry, E. Azoulay, F. Beganton, D. Benhamou, W. Bougouin, C. Bruel, A. Cariou, P. Carli, C. Cerf, A. Chaib, J. Chastre, Y. Cohen, A. Combes, C. Cornaglia, D. Da Silva, V. Das, A. Demoule, N. Deye, G. Dhonneur, J.L. Diehl, S. Dinanian, L. Domanski, D. Dreyfuss, D. Duboc, J.L. Dubois-Rande, O. Dubourg, F.X. Duchateau, F. Dumas, J.P. Empana, F. Extramiana, J.Y. Fagon, M. Fartoukh, C. Fenioux, F. Fieux, F. Fraisse, M. Gabbas, E. Gandjbakhch, B. Guidet, P. Henry, F. Hidden Lucet, P. Jabre, L. Jacob, L. Joseph, D. Jost, D. Journois, X. Jouven, N. Karam, H. Kassim, K. Lahlou-Laforet, L. Lamhaut, A. Lanceleur, O. Langeron, V. Lanoe, E. Lecarpentier, A. Leenhardt, N. Lellouche, V. Lemiale, F. Linval, T. Loeb, B. Ludes, A. Maltret, N. Mansouri, J. Mantz, E. Marijon, J. Marty, E. Maury, V. Maxime, A. Mekontso-Dessaps, J.P. Mira, X. Monnet, M.C. Perier, O. Piot, R. Pirraccchio, I. Plu, M. Raux, F. Revaux, J.D. Ricard, C. Richard, B. Riou, F. Roussin, F. Santoli, F. Schortgen, T. Sharshar, G. Sideris, C. Spaulding, J.L. Teboul, J.F. Timsit, J.P. Tourtier, P. Tuppin, C. Ursat, O. Varenne, A. Vieillard-Baron, S. Voicu, and K. Wahbi

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Basic life support, Percutaneous coronary intervention, 030208 emergency & critical care medicine, 030204 cardiovascular system & hematology, Return of spontaneous circulation, Coronary angiogram, Logistic regression, Sudden death, 03 medical and health sciences, 0302 clinical medicine, Epinephrine, Internal medicine, medicine, Cardiology, Hospital discharge, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Objectives This study sought to assess the relationship between an immediate invasive strategy and survival after an out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause, according to prognosis evaluated on hospital arrival. Background An immediate coronary angiogram (CAG) may be associated with better outcome after OHCA in neurologically preserved patients but could be futile in other cases. Methods From May 2011 to May 2015, we collected data for all patients admitted in hospital after OHCA in Paris and its suburbs (France). Risk of in-hospital death was retrospectively calculated using the validated Cardiac Arrest Hospital Prognosis score, which includes age, setting, initial rhythm, durations from collapse to basic life support and from basic life support to return of spontaneous circulation, pH, and epinephrine dose. Independent predictors of survival at discharge (including immediate CAG) were assessed in multivariate logistic regression in each of the 3 pre-defined subgroups of Cardiac Arrest Hospital Prognosis score: low risk ( 200 points) for in-hospital death. Results A total of 1,410 patients were included and overall survival rate at hospital discharge was 32%. Distribution in the low-, medium-, and high-risk Cardiac Arrest Hospital Prognosis subgroups was 667 (47%), 469 (33%), and 274 patients (20%), respectively. The rate of early CAG was 86%, 66%, and 47% in the low-, medium-, and high-risk subgroups, respectively (p Conclusions In cardiac arrest patients, our results suggest that investigations regarding early CAG after OHCA should focus on patients with preserved neurological status.

Published
2018
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