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6 results on '"M.J. Schumacher"'

1. Heterogeneity of Pollen Proteins within Individual Betula Pendula Trees

Author

Mervi Hjelmroos, M. van Hage-Hamsten, and M.J. Schumacher

Subjects
Betulaceae, biology, fungi, Immunology, food and beverages, Cross reactions, General Medicine, medicine.disease_cause, biology.organism_classification, Environmental effect, Birch pollen, Water soluble, Betula pendula, Pollen, Botany, otorhinolaryngologic diseases, medicine, Antigenic variation, Immunology and Allergy
Abstract

To determine the variation of antigenic water soluble proteins in white birch ( Betula pendula ) pollen, extracts of pollen from different sides of individual trees were analyzed by i

Published
1995
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2. Contents, Vol. 108, 1995

Author

Douglas B. Lowrie, H. Wolf, M. van Hage-Hamsten, Peter Berger, David C. Wraith, G. Wick, Boris Albini, Margaret I. Johnston, Ruth Arnon, Murray W. Stinson, Felix Milgrom, Ricardo E. Tascon, Ingrid Glurich, Mariagrazia Pizza, V. Schirrmacher, Reiji Kasukawa, Gordon Dougan, Gordon Ada, Felix Mor, Stephan Dirnhofer, Mervi Hjelmroos, Hans Dieter Brede, Masayuki Miyata, Rino Rappuoli, M.J. Schumacher, Gill Douce, Célio Lopes Silva, Y Shoenfeld, Christiane Ruedl, Raphael Levi, Irun R. Cohen, and Yves Levy

Subjects
Philosophy, Immunology, Immunology and Allergy, General Medicine
Published
1995
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3. Subject Index Vol. 108, 1995

Author

Reiji Kasukawa, David C. Wraith, Christiane Ruedl, H. Wolf, Irun R. Cohen, Margaret I. Johnston, V. Schirrmacher, Felix Milgrom, M. van Hage-Hamsten, Y Shoenfeld, Murray W. Stinson, Stephan Dirnhofer, Ingrid Glurich, Felix Mor, Rino Rappuoli, Peter Berger, Masayuki Miyata, Raphael Levi, M.J. Schumacher, G. Wick, Gill Douce, Célio Lopes Silva, Yves Levy, Boris Albini, Mariagrazia Pizza, Ricardo E. Tascon, Douglas B. Lowrie, Mervi Hjelmroos, Gordon Dougan, Gordon Ada, Ruth Arnon, and Hans Dieter Brede

Subjects
Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1995
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5. Contents, Vol. 62, 1980

Author

K.-E. Gillert, Norio Onizawa, J.R. White, David Rosenzweig, T.-M. Ernst, J.M. Styles, M.J. Schumacher, Hisashi Kuriki, R.K. Barfoot, A.L. de Weck, Zarina Goel, Mitzi Nagarkatti, R.G. Navalkar, Kumagai A, A. Truneh, C.J. Dean, Michael H. Grieco, S. Muller, Reiji Kasukawa, P.J. Patel, S. Denham, Madeleine Ennis, Frederick L. Pearce, Mathias Onsrud, Thomas Nall, Kola M. Rao, Taketoshi Saijo, J.P. Soulillou, Dana Wallace, Hisao Tomioka, G. Lavergne, M.A. Kings, P.J. Neveu, Takashi Tada, H.S. Buttare, David K. Meriney, M.V. Kanchana, Erik Thorsby, Takao Morito, Prakash S. Nagarkatti, Yasuko Ashida, Hiroshi Yoshida, T Itaya, N. Buscot, Graham F. Mitchell, H.M. Vijay, and Yoshitaka Maki

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1980
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6. Significance of concordant fluctuation and loss of leukocyte sensitivity to two allergens during injection therapy with one nonspecific desensitization

Author

M.J. Schumacher, C.S. Williams, and C.D. May

Subjects
medicine.medical_treatment, Immunology, medicine.disease_cause, Histamine Release, Subcutaneous injection, chemistry.chemical_compound, Allergen, immune system diseases, otorhinolaryngologic diseases, medicine, Leukocytes, Immunology and Allergy, Humans, Child, Asthma, Desensitization (medicine), business.industry, Injection therapy, Fungi, respiratory system, Allergens, medicine.disease, In vitro, respiratory tract diseases, Peripheral, chemistry, Desensitization, Immunologic, Pollen, business, Histamine
Abstract

Concordant, nearly parallel fluctuations in leukocyte sensitivity to 2 unrelated allergens were repeatedly observed during injection therapy with one of the allergens. In one case, complete loss of sensitivity or unresponsiveness to 2 unrelated allergens occurred during injection therapy with one. This nonspecific desensitization is considered to result from exposure of the sensitized leukocytes to concentrations of one of the allergens below the concentration required for detectable histamine release. This explanation is supported by data obtained by exposure of leukocytes in vitro to subthreshold concentrations of allergen, which resulted in decreased response in histamine release by the allergen used for desensitization and an unrelated allergen. In addition, intravenous infusion of allergen in low concentration into children likewise induced nonspecific desensitization of circulating leukocytes to 2 unrelated allergens. Concordant fluctuations and occasional nonspecific loss of leukocyte sensitivity to unrelated allergens during customary subcutaneous injection therapy may result from uneven or inadequate absorption of free allergen from the subcutaneous tissues into the circulation, thereby reaching desensitizing concentrations intermittently. This phenomenon calls for caution in assuming that the fluctuations of peripheral leukocyte sensitivity during injection therapy are necessarily a reflection of sensitivity of cells in the tissues.

Published
1972

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