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Abemaciclib; Adjuvant; Early breast cancer Abemaciclib; Adjuvant; Càncer de mama precoç Abemaciclib; Adyuvante; Cáncer de mama precoz Background Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, high-risk early breast cancer at the second interim analysis, however follow-up was limited. Here, we present results of the prespecified primary outcome analysis and an additional follow-up analysis. Patients and methods This global, phase III, open-label trial randomized (1 : 1) 5637 patients to adjuvant ET for ≥5 years ± abemaciclib for 2 years. Cohort 1 enrolled patients with ≥4 positive axillary lymph nodes (ALNs), or 1-3 positive ALNs and either grade 3 disease or tumor ≥5 cm. Cohort 2 enrolled patients with 1-3 positive ALNs and centrally determined high Ki-67 index (≥20%). The primary endpoint was IDFS in the intent-to-treat population (cohorts 1 and 2). Secondary endpoints were IDFS in patients with high Ki-67, DRFS, overall survival, and safety. Results At the primary outcome analysis, with 19 months median follow-up time, abemaciclib + ET resulted in a 29% reduction in the risk of developing an IDFS event [hazard ratio (HR) = 0.71, 95% confidence interval (CI) 0.58-0.87; nominal P = 0.0009]. At the additional follow-up analysis, with 27 months median follow-up and 90% of patients off treatment, IDFS (HR = 0.70, 95% CI 0.59-0.82; nominal P < 0.0001) and DRFS (HR = 0.69, 95% CI 0.57-0.83; nominal P < 0.0001) benefit was maintained. The absolute improvements in 3-year IDFS and DRFS rates were 5.4% and 4.2%, respectively. Whereas Ki-67 index was prognostic, abemaciclib benefit was consistent regardless of Ki-67 index. Safety data were consistent with the known abemaciclib risk profile. Conclusion Abemaciclib + ET significantly improved IDFS in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, high-risk early breast cancer, with an acceptable safety profile. Ki-67 index was prognostic, but abemaciclib benefit was observed regardless of Ki-67 index. Overall, the robust treatment benefit of abemaciclib extended beyond the 2-year treatment period. This work was supported by the sponsor (Eli Lilly and Company) and designed together with the study Executive Committee (no grant number).

A desire to incorporate multiple functions into a single component continues to drive product size reduction in the wireless electronics industry. In the radio portion of wireless handsets, many of the functions have been modularized. Because surface acoustic wave (SAW) devices are built using a piezoelectric substrate, they require unique packaging in order to ensure their functionality. Some form of a hermetic cavity over the active area of the SAW die is necessary to avoid damage or mass loading to the unpassivated surface. This paper reviews the nature of the RF SAW filters and current packaging approaches. A novel encapsulation process for these filters is discussed. The active area of the filter is protected at the wafer level by a low profile hermetic lid. It can thereafter be tested, singulated and integrated along with other devices into a module. Examples of modules used in wireless products with integrated SAW filters are given.

The authors describe the design and fabrication of a K/sub a/-band, multilayer, multielement module and present preliminary performance data. This module can be used in advanced phased-array antenna systems. The module makes efficient use of physical volume, and provides reduced interconnect requirements for the array controller. The consolidation of MMIC (monolithic microwave integrated circuit) and ASIC (application-specific integrated circuit) devices into a single package with integral radiating elements has been shown to be feasible. Scattering parameter measurements were made of the module to assess the millimeter-wave performance of the transmission line structures. >

Decoupling capacitors have been designed and included in high-speed packaging systems to avoid voltage drops across the power supply caused by interconnect inductance. They are also used to reduce simultaneous switching noise between the power supply and device I/O buffers. This paper will review three different measurement methods by which these capacitors were analyzed. It will discuss the possible detriments when making both low frequency and high frequency measurements on electronic packages and surface mount chip components using commercial instruments and fixtures. Two different types of high performance electronic packages with integral decoupling capacitors were analyzed. The models derived from the measurements were included in a circuit simulation to determine the effectiveness of decoupling noise between the device drivers and the system power supply. The results will provide insight into the effectiveness or these types of capacitors used within a high-speed electronic system.

A feedthrough using a microstrip to stripline to conductor backed coplanar waveguide (CBCWG) design was investigated for microwave performance. The feedthrough was manufactured using a high-temperature cofired multilayer ceramic process. The study was instigated from the need to have a field-replaceable, Ku-band transmit/receive module as part of an existing DARPA MIMIC program. The result is a feedthrough capable of transmitting microwave frequencies to 24 GHz with acceptable loss characteristics. The feedthrough performance exceeds published results. >