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7. Leukocyte telomere length throughout the continuum of colorectal carcinogenesis

Author

Zöchmeister, Cornelia, primary, Brezina, Stefanie, additional, Hofer, Philipp, additional, Baierl, Andreas, additional, Bergmann, Michael M., additional, Bachleitner-Hofmann, Thomas, additional, Karner-Hanusch, Judith, additional, Stift, Anton, additional, Gerger, Armin, additional, Leeb, Gernot, additional, Mach, Karl, additional, Rachakonda, Sivaramakrishna, additional, Kumar, Rajiv, additional, and Gsur, Andrea, additional

Published
2018
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8. Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas

Author

Hofer, Philipp, primary, Hagmann, Michael, additional, Brezina, Stefanie, additional, Dolejsi, Erich, additional, Mach, Karl, additional, Leeb, Gernot, additional, Baierl, Andreas, additional, Buch, Stephan, additional, Sutterlüty-Fall, Hedwig, additional, Karner-Hanusch, Judith, additional, Bergmann, Michael M., additional, Bachleitner-Hofmann, Thomas, additional, Stift, Anton, additional, Gerger, Armin, additional, Rötzer, Katharina, additional, Karner, Josef, additional, Stättner, Stefan, additional, Waldenberger, Melanie, additional, Meitinger, Thomas, additional, Strauch, Konstantin, additional, Linseisen, Jakob, additional, Gieger, Christian, additional, Frommlet, Florian, additional, and Gsur, Andrea, additional

Published
2017
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9. The Immunome of Colon Cancer: Functional In SilicoAnalysis of Antigenic Proteins Deduced from IgG Microarray Profiling

Author

Luna Coronell, Johana A., Sergelen, Khulan, Hofer, Philipp, Gyurján, István, Brezina, Stefanie, Hettegger, Peter, Leeb, Gernot, Mach, Karl, Gsur, Andrea, and Weinhäusel, Andreas

Abstract

Characterization of the colon cancer immunome and its autoantibody signature from differentially-reactive antigens (DIRAGs) could provide insights into aberrant cellular mechanisms or enriched networks associated with diseases. The purpose of this study was to characterize the antibody profile of plasma samples from 32 colorectal cancer(CRC) patients and 32 controls using proteins isolated from 15,417 human cDNA expression clones on microarrays. 671 unique DIRAGs were identified and 632 were more highly reactive in CRC samples. Bioinformatics analyses reveal that compared to control samples, the immunoproteomic IgG profiling of CRC samples is mainly associated with cell death, survival, and proliferation pathways, especially proteins involved in EIF2 and mTOR signaling. Ribosomal proteins (e.g., RPL7, RPL22, and RPL27A) and CRC-related genes such as APC, AXIN1, E2F4, MSH2, PMS2, and TP53were highly enriched. In addition, differential pathways were observed between the CRC and control samples. Furthermore, 103 DIRAGs were reported in the SEREX antigen database, demonstrating our ability to identify known and new reactive antigens. We also found an overlap of 7 antigens with 48 “CRC genes.” These data indicate that immunomicsprofiling on protein microarraysis able to reveal the complexity of immune responses in cancerous diseases and faithfully reflects the underlying pathology.

Published
2018
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