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2. Corrigendum: D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: a multi-national case series from different waves

Author

Diana Maria Ronderos Botero, Alaa Mabrouk Salem Omar, Martino F. Pengo, Syed Waqas Haider, Hira Latif, Gianfranco Parati, Vittorio Pengo, Alejandra Cañas Arboleda, Melissa Díaz, Claudio Villaquirán-Torres, Johanna Contreras, and Sridhar Chilimuri

Subjects
COVID-19, D-dimer, variability, in-hospital mortality, heterogeneity, Medicine (General), R5-920
Published
2023
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3. The effect of transcutaneous electrical stimulation of the submental area on the cardiorespiratory response in normal and awake subjects

Author

Abdulaziz Alsharifi, Georgios Kaltsakas, Martino F. Pengo, Gianfranco Parati, Miquel Serna-Pascual, Gerrard Rafferty, and Joerg Steier

Subjects
sleep apnoea, sleep-disordered breathing, upper airway physiology, hypoxia, blood pressure, Physiology, QP1-981
Abstract

Background: Electrical stimulation has recently been introduced to treat patients with Obstructive sleep apnoea There are, however, few data on the effects of transcutaneous submental electrical stimulation (TES) on the cardiovascular system. We studied the effect of TES on cardiorespiratory variables in healthy volunteers during head-down-tilt (HDT) induced baroreceptor loading.Method: Cardiorespiratory parameters (blood pressure, heart rate, respiratory rate, tidal volume, airflow/minute ventilation, oxygen saturation, and end-tidal CO2/O2 concentration) were recorded seated, supine, and during head-down-tilt (50) under normoxic, hypercapnic (FiCO2 5%) and poikilocapnic hypoxic (FiO2 12%) conditions. Blood pressure (BP) was measured non-invasively and continuously (Finapres). Gas conditions were applied in random order. All participants were studied twice on different days, once without and once with TES.Results: We studied 13 healthy subjects (age 29 (12) years, six female, body mass index (BMI) 23.23 (1.6) kg·m−2). A three-way ANOVA indicated that BP decreased significantly with TES (systolic: p = 4.93E-06, diastolic: p = 3.48E-09, mean: p = 3.88E-08). Change in gas condition (systolic: p = 0.0402, diastolic: p = 0.0033, mean: p = 0.0034) and different postures (systolic: 8.49E-08, diastolic: p = 6.91E-04, mean: p = 5.47E-05) similarly impacted on BP control. When tested for interaction, there were no significant associations between the three different factors electrical stimulation, gas condition, or posture, except for an effect on minute ventilation (gas condition/posture p = 0.0369).Conclusion: Transcutaneous electrical stimulation has a substantial impact on the blood pressure. Similarly, postural changes and variations in inspired gas impact on blood pressure control. Finally, there was an interaction between posture and inspired gases that affects minute ventilation. These observations have implications on our understanding of integrated cardiorespiratory control, and may prove beneficial for patients with SDB who are assessed for treatment with electrical stimulation.

Published
2023
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4. D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves

Author

Diana Maria Ronderos Botero, Alaa Mabrouk Salem Omar, Martino F. Pengo, Syed Waqas Haider, Hira Latif, Gianfranco Parati, Vittorio Pengo, Alejandra Cañas Arboleda, Melissa Díaz, Claudio Villaquirán-Torres, Johanna Contreras, and Sridhar Chilimuri

Subjects
COVID-19, D-dimer, variability, in-hospital mortality, heterogeneity, Medicine (General), R5-920
Abstract

IntroductionVariable D-dimer trends during hospitalization reportedly result in distinct in-hospital mortality. In this multinational case series from the first and second waves, we show the universality of such D-dimer trends.MethodsWe reviewed 405 patients with COVID-19 during the first wave admitted to three institutions in the United States, Italy, and Colombia, and 111 patients admitted to the U.S. site during the second wave and 55 patients during the third wave. D-dimer was serially followed during hospitalization.ResultsDuring the first wave, 66 (15%) patients had a persistently-low pattern, 33 (8%) had early-peaking, 70 (16%) had mid-peaking, 94 (22%) had fluctuating, 30 (7%) had late-peaking, and 112 (26%) had a persistently-high pattern. During the second and third waves, similar patterns were observed. D-dimer patterns were significantly different in terms of in-hospital mortality similarly in all waves. Patterns were then classified into low-risk patterns (persistently-low and early-peaking), where no deaths were observed in both waves, high-risk patterns (mid-peaking and fluctuating), and malignant patterns (late-peaking and persistently-high). Overall, D-dimer trends were associated with an increased risk for in-hospital mortality in the first wave (overall: HR: 1.73) and stayed the same during the second (HR: 1.67, p < 0.001) and the third (HR: 4.4, p = 0.001) waves.ConclusionD-dimer behavior during COVID-19 hospitalization yielded universal categories with distinct mortality risks that persisted throughout all studied waves of infection. Monitoring D-dimer behavior may be useful in the management of these patients.

Published
2023
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6. Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

Author

Irene Campi, Luigi Gennari, Daniela Merlotti, Christian Mingiano, Alessandro Frosali, Luca Giovanelli, Camilla Torlasco, Martino F. Pengo, Francesca Heilbron, Davide Soranna, Antonella Zambon, Marta Di Stefano, Carmen Aresta, Marco Bonomi, Biagio Cangiano, Vittoria Favero, Letizia Fatti, Giovanni Battista Perego, Iacopo Chiodini, Gianfranco Parati, and Luca Persani

Subjects
Vitamin D, COVID-19, Mortality, Interleukin-6, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Vitamin D deficiency has been suggested to favor a poorer outcome of Coronavirus disease-19 (COVID-19). We aimed to assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) levels and with disease severity and mortality in COVID-19. Methods We prospectively studied 103 in-patients admitted to a Northern-Italian hospital (age 66.1 ± 14.1 years, 70 males) for severely-symptomatic COVID-19. Fifty-two subjects with SARS-CoV-2 infection but mild COVID-19 symptoms (mildly-symptomatic COVID-19 patients) and 206 subjects without SARS-CoV-2 infection were controls. We measured 25OHD and IL-6 levels at admission and focused on respiratory outcome during hospitalization. Results Severely-symptomatic COVID-19 patients had lower 25OHD levels (18.2 ± 11.4 ng/mL) than mildly-symptomatic COVID-19 patients and non-SARS-CoV-2-infected controls (30.3 ± 8.5 ng/mL and 25.4 ± 9.4 ng/mL, respectively, p

Published
2021
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7. A sleep apnoea questionnaire predicts organ damage in hypertensive patients

Author

Valeria Bisogni, Martino F. Pengo, Giuseppe Maiolino, Maurizio Cesari, Silvia Lerco, Giacomo Rossitto, Antonio Concistrè, Luigi Petramala, Claudio Letizia, Teresa Maria Seccia, and Gian Paolo Rossi

Subjects
obstructive sleep apnoea, insomnia, restless legs syndrome, hypertension, hypertension-mediated organ damage, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Arterial hypertension is associated with obstructive sleep apnoea, poor quality and duration of sleep, which might contribute to hypertension-mediated organ damage. Methods: We investigated the presence of insomnia, restless legs syndrome, and obstructive sleep apnoea using validated questionnaires (Insomnia Severity Index, Restless Legs Syndrome Rating Scale, and STOP-Bang), and their relationship with hypertension-mediated organ damage, in hypertensive patients. Results: In 159 consecutive consenting hypertensive patients [age 47(11) years, median and (interquartile range), body mass index 25.5(5.9) kg/m2, office systolic and diastolic blood pressure 144(23)/92(12) mmHg], the STOP-Bang, but not the other scores, predicted cardiac remodelling: compared to patients with a STOP-Bang score < 3, those at high risk of obstructive sleep apnoea showed higher left ventricular mass index [49.8(11.9) vs. 43.3(11.9) g/m2.7, p

Published
2019
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8. The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism

Author

Gian Paolo Rossi, Valeria Bisogni, Alessandra Violet Bacca, Anna Belfiore, Maurizio Cesari, Antonio Concistrè, Rita Del Pinto, Bruno Fabris, Francesco Fallo, Cristiano Fava, Claudio Ferri, Gilberta Giacchetti, Guido Grassi, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Giuseppe Maiolino, Dario Manfellotto, Pietro Minuz, Silvia Monticone, Alberto Morganti, Maria Lorenza Muiesan, Paolo Mulatero, Aurelio Negro, Gianfranco Parati, Martino F. Pengo, Luigi Petramala, Francesca Pizzolo, Damiano Rizzoni, Giacomo Rossitto, Franco Veglio, and Teresa Maria Seccia

Subjects
Primary aldosteronism, Hypertension, Guidelines, Diagnosis, Treatment, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background and aim: Considering the amount of novel knowledge generated in the last five years, a team of experienced hypertensionlogists was assembled to furnish updated clinical practice guidelines for the management of primary aldosteronism. Methods: To identify the most relevant studies, the authors utilized a systematic literature review in international databases by applying the PICO strategy, and then they were required to make use of only those meeting predefined quality criteria. For studies of diagnostic tests, only those that fulfilled the Standards for Reporting of Diagnostic Accuracy recommendations were considered. Results: Each section was jointly prepared by at least two co-authors, who provided Class of Recommendation and Level of Evidence following the American Heart Association methodology. The guidelines were sponsored by the Italian Society of Arterial Hypertension and underwent two rounds of revision, eventually reexamined by an External Committee. They were presented and thoroughly discussed in two face-to-face meetings with all co-authors and then presented on occasion of the 36th Italian Society of Arterial Hypertension meeting in order to gather further feedbacks by all members. The text amended according to these feedbacks was subjected to a further peer review. Conclusions: After this process, substantial updated information was generated, which could simplify the diagnosis of primary aldosteronism and assist practicing physicians in optimizing treatment and follow-up of patients with one of the most common curable causes of arterial hypertension.

Published
2020
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9. The acute effect of continuous positive airway pressure titration on blood pressure in awake overweight/obese patients with obstructive sleep apnoea

Author

Culadeeban Ratneswaran, Martino F. Pengo, Sichang Xiao, Yuanming Luo, Gian Paolo Rossi, Michael I. Polkey, John Moxham, and Joerg Steier

Subjects
hypertension, variability, sympathetic, cardiovascular, obesity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular system in obese patients has not been described in detail. Methods: Obese patients (body mass index, BMI > 25 kg/m2) with OSA were studied awake, supine during incremental CPAP titration (4–20 cmH2O, +2 cmH2O/3 mins). BP was measured continuously with a beat-to-beat BP monitor (Ohmeda 2300, Finapres Medical Systems, Amsterdam/NL), BP variability (BPV) was calculated as the standard deviation of BP at each CPAP level, the 95% confidence interval (95%CI) was calculated and changes in BP and BPV were reported. Results: 15 patients (12 male, 48 ± 10) years, BMI 38.9 ± 5.8 kg/m2) were studied; the baseline BP was 131.0 ± 10.2/85.1 ± 9.1 mmHg. BP and BPV increased linearly with CPAP titration (systolic BP r = 0.960, p

Published
2018
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10. Classifying spam emails using agglomerative hierarchical clustering and a topic-based approach

Author

Janez-Martino, F., Alaiz-Rodriguez, R., Gonzalez-Castro, V., Fidalgo, E., and Alegre, E.

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Spam emails are unsolicited, annoying and sometimes harmful messages which may contain malware, phishing or hoaxes. Unlike most studies that address the design of efficient anti-spam filters, we approach the spam email problem from a different and novel perspective. Focusing on the needs of cybersecurity units, we follow a topic-based approach for addressing the classification of spam email into multiple categories. We propose SPEMC-15K-E and SPEMC-15K-S, two novel datasets with approximately 15K emails each in English and Spanish, respectively, and we label them using agglomerative hierarchical clustering into 11 classes. We evaluate 16 pipelines, combining four text representation techniques -Term Frequency-Inverse Document Frequency (TF-IDF), Bag of Words, Word2Vec and BERT- and four classifiers: Support Vector Machine, N\"aive Bayes, Random Forest and Logistic Regression. Experimental results show that the highest performance is achieved with TF-IDF and LR for the English dataset, with a F1 score of 0.953 and an accuracy of 94.6%, and while for the Spanish dataset, TF-IDF with NB yields a F1 score of 0.945 and 98.5% accuracy. Regarding the processing time, TF-IDF with LR leads to the fastest classification, processing an English and Spanish spam email in and on average, respectively.

Published
2024

11. In Patients with Chronic Kidney Disease Short Term Blood Pressure Variability is Associated with the Presence and Severity of Sleep Disorders

Author

Martino F. Pengo, Donatella Ioratti, Valeria Bisogni, Verdiana Ravarotto, Barbara Rossi, Luciana Bonfante, Francesca Simioni, Federico Nalesso, Giuseppe Maiolino, and Lorenzo A. Calò

Subjects
Blood pressure variability, CKD, Insomnia, Sleep quality, Restless legs syndrome, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Background/Aims: In chronic kidney disease (CKD) patients blood pressure variability (BPV) is associated with poor outcome. Sleep disturbances alter BP profiles in hypertensives but their influence on BPV in CKD patients is unknown. We screened a cohort of CKD/ESRD patients to investigate whether sleep quality impacts on BPV. Methods: Consecutive CKD patients’ sleep quality was assessed using validated questionnaires (Epworth Sleepiness Scale-ESS); International Restless legs scale-IRLS; Functional Outcomes of Sleep Questionnaire-FOSQ: Insomnia Severity Index-ISI; STOP-Bang). All patients underwent ambulatory blood pressure measurement. Results: 104 out of 143 enrolled patients (78.32% stage-3 CKD; 10.49% Stage-4; 11.19% Stage-5; 6.99% ESRD-under dialysis) completed all the questionnaires. 95.8% were hypertensives, 70% were non-dippers and 27.8% had resistant hypertension. STOP-Bang>4 proved sleep disorders in 84.84% of patients. Patients with IRLS>10 had greater diastolic nocturnal standard deviation (DNSD) and a trend (p=0.05) for systolic nocturnal SD (SNSD). Patients with ISI>14 had greater SNSD and in 28.8% FOSQ showed severely impaired sleep quality. Their systolic nocturnal BPV was significantly greater. ISI was independently associated with SNSD. FOSQ and diastolic nocturnal BPV were negatively correlated at the bivariate analysis and FOSQ independently predicts systolic nocturnal BPV at multivariate regression analysis. Conclusions: In CKD patients impaired sleep quality increases BPV, might contribute to their disease progression and worsen prognosis. Searching for sleep problems in CKD patients could help planning their treatment of sleep problems contributing to CV risk reduction. Our data provide the rationale working hypothesis for the need of studies with larger number of patients aimed to demonstrate improved outcome of CKD progression and CV risk with the treatment also of sleep disorders.

Published
2017
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14. The $2\times 2$ upper triangular matrix algebra and its generalized polynomial identities

Author

Martino, F. and Rizzo, C.

Subjects
Mathematics - Rings and Algebras, 16R10, 16R50 (Primary) 16P90, 20C30 (Secondary)
Abstract

Let $UT_2$ be the algebra of $2\times 2$ upper triangular matrices over a field $F$ of characteristic zero. Here we study the generalized polynomial identities of $UT_2$, i.e., identical relations holding for $UT_2$ regarded as $UT_2$-algebra. We determine a set of two generators of the $T_{UT_2}$-ideal of generalized polynomial identities of $UT_2$ and compute the exact values of the corresponding sequence of generalized codimensions. Moreover, we give a complete description of the space of multilinear generalized identities in $n$ variables in the language of Young diagrams through the representation theory of the symmetric group $S_n$. Finally, we prove that, unlike in the ordinary case, the generalized variety of $UT_2$-algebras generated by $UT_2$ has no almost polynomial growth; nevertheless, we exhibit two distinct generalized varieties of almost polynomial growth., Comment: 12 pages

Published
2023
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15. Cost-effectiveness analysis of online hemodiafiltration versus high-flux hemodialysis

Author

Ramponi F, Ronco C, Mason G, Rettore E, Marcelli D, Martino F, Neri M, Martin-Malo A, Canaud B, and Locatelli F

Subjects
cost-effectiveness, hemodialysis, hemodiafiltration, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Francesco Ramponi,1,2 Claudio Ronco,1,3 Giacomo Mason,1 Enrico Rettore,4 Daniele Marcelli,5,6 Francesca Martino,1,3 Mauro Neri,1,7 Alejandro Martin-Malo,8 Bernard Canaud,5,9 Francesco Locatelli10 1International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, 2Department of Economics and Management, University of Padova, Padova, 3Department of Nephrology, San Bortolo Hospital, Vicenza, 4Department of Sociology and Social Research, University of Trento, FBK-IRVAPP & IZA, Trento, Italy; 5Europe, Middle East, Africa and Latin America Medical Board, Fresenius Medical Care,, Bad Homburg, Germany; 6Danube University, Krems, Austria; 7Department of Management and Engineering, University of Padova, Vicenza, Italy; 8Nephrology Unit, Reina Sofia University Hospital, Córdoba, Spain; 9School of Medicine, Montpellier University, Montpellier, France; 10Department of Nephrology, Manzoni Hospital, Lecco, Italy Background: Clinical studies suggest that hemodiafiltration (HDF) may lead to better clinical outcomes than high-flux hemodialysis (HF-HD), but concerns have been raised about the cost-effectiveness of HDF versus HF-HD. Aim of this study was to investigate whether clinical benefits, in terms of longer survival and better health-related quality of life, are worth the possibly higher costs of HDF compared to HF-HD.Methods: The analysis comprised a simulation based on the combined results of previous published studies, with the following steps: 1) estimation of the survival function of HF-HD patients from a clinical trial and of HDF patients using the risk reduction estimated in a meta-analysis; 2) simulation of the survival of the same sample of patients as if allocated to HF-HD or HDF using three-state Markov models; and 3) application of state-specific health-related quality of life coefficients and differential costs derived from the literature. Several Monte Carlo simulations were performed, including simulations for patients with different risk profiles, for example, by age (patients aged 40, 50, and 60 years), sex, and diabetic status. Scatter plots of simulations in the cost-effectiveness plane were produced, incremental cost-effectiveness ratios were estimated, and cost-effectiveness acceptability curves were computed.Results: An incremental cost-effectiveness ratio of €6,982/quality-adjusted life years (QALY) was estimated for the baseline cohort of 50-year-old male patients. Given the commonly accepted threshold of €40,000/QALY, HDF is cost-effective. The probabilistic sensitivity analysis showed that HDF is cost-effective with a probability of ~81% at a threshold of €40,000/QALY. It is fundamental to measure the outcome also in terms of quality of life. HDF is more cost-effective for younger patients.Conclusion: HDF can be considered cost-effective compared to HF-HD. Keywords: cost-effectiveness, hemodialysis, hemodiafiltration

Published
2016

18. Telemedicine and Digital Medicine in the Clinical Management of Hypertension and Hypertension-Related Cardiovascular Diseases: A Position Paper of the Italian Society of Arterial Hypertension (SIIA)

Author

Minuz, Pietro, Albini, Fabio Lucio, Imbalzano, Egidio, Izzo, Raffaele, Masi, Stefano, Pengo, Martino F., Pucci, Giacomo, Scalise, Filippo, Salvetti, Massimo, Tocci, Giuliano, Cicero, Arrigo, Iaccarino, Guido, Savoia, Carmine, Sechi, Leonardo, Parati, Gianfranco, Borghi, Claudio, Volpe, Massimo, Ferri, Claudio, Grassi, Guido, and Muiesan, Maria Lorenza

Published
2023
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23. Perspectives in linear accelerator for FLASH VHEE: Study of a compact C-band system

Author

Faillace, L., Alesini, D., Bisogni, G., Bosco, F., Carillo, M., Cirrone, P., Cuttone, G., De Arcangelis, D., De Gregorio, A., Di Martino, F., Favaudon, V., Ficcadenti, L., Francescone, D., Franciosini, G., Gallo, A., Heinrich, S., Migliorati, M., Mostacci, A., Palumbo, L., Patera, V., Patriarca, A., Pensavalle, J., Perondi, F., Remetti, R., Sarti, A., Spataro, B., Torrisi, G., Vannozzi, A., and Giuliano, L.

Published
2022
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24. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration

Author

Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, H, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, J, Wit, F, Menozzi, M, d'Arminio Monforte, A, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, S, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, Calvo, G, Dabis, F, Kirk, O, Law, M, Monforte, A, Morfeldt, L, Reiss, P, Weber, R, Lind-Thomsen, A, Brandt, R, Hillebreght, M, Zaheri, S, Scherrer, A, Schöni-Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Dollet, K, Mateu, S, Torres, F, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, A, Kamara, D, Smith, C, Hatleberg, C, Raben, D, Matthews, C, Bojesen, A, Grevsen, A, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, C, Morlat, P, Friis-Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, J, Reiss, C, Hillebregt, M, Prins, J, Kuijpers, T, Scherpbier, H, van der Meer, J, Godfried, M, van der Poll, T, Nellen, F, Geerlings, S, van Vugt, M, Pajkrt, D, Bos, J, Wiersinga, W, van der Valk, M, Goorhuis, A, Hovius, J, van Eden, J, Henderiks, A, van Hes, A, Mutschelknauss, M, Nobel, H, Pijnappel, F, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Thomas, X, Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Ziekenhuis, C, Pronk, M, Ammerlaan, H, De Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van der Plas, A, Weijsenfeld, A, van der Ende, M, De Vries-Sluijs, T, van Gorp, E, Schurink, C, Nouwen, J, Verbon, A, Rijnders, B, Bax, H, van der Feltz, M, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, de Oude-Lubbers, A, van den Berg-Cameron, H, Bruinsma-Broekman, F, de Groot, J, de Man, M, Boucher, C, Koopmans, M, van Kampen, J, Pas, S, Mc–sophia, E, Driessen, G, van Rossum, A, van der Knaap, L, Visser, E, Branger, J, Rijkeboer-Mes, A, de Ven, C, Ziekenhuis, H, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, Franck, P, van Eeden, A, Brokking, W, Groot, M, Elsenburg, L, Damen, M, Kwa, I, Groeneveld, P, Bouwhuis, J, van den Berg, J, van Hulzen, A, van der Bliek, G, Bor, P, Bloembergen, P, Wolfhagen, M, Ruijs, G, Kroon, F, de Boer, M, Bauer, M, Jolink, H, Vollaard, A, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, Pogany, K, Roukens, A, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, S, Lashof, A, Posthouwer, D, Ackens, R, Schippers, J, Vergoossen, R, Weijenberg-Maes, B, van Loo, I, Havenith, T, Leyten, E, Gelinck, L, van Hartingsveld, A, Meerkerk, C, Wildenbeest, G, Mutsaers, J, Jansen, C, Mulder, J, Vrouenraets, S, Lauw, F, van Broekhuizen, M, Paap, H, Vlasblom, D, Smits, P, Zuiderzee, M, Weijer, S, El Moussaoui, R, Bosma, A, van Vonderen, M, van Houte, D, Kampschreur, L, Dijkstra, K, Faber, S, Weel, J, Kootstra, G, Delsing, C, van der Burg-van de Plas, M, Heins, H, Lucas, E, Kortmann, W, van Twillert, G, Stuart, J, Diederen, B, Pronk, D, van Truijen-Oud, F, van der Reijden, W, Jansen, R, Brinkman, K, van den Berk, G, Blok, W, Frissen, P, Lettinga, K, Schouten, W, Veenstra, J, Brouwer, C, Geerders, G, Hoeksema, K, Kleene, M, van der Meché, I, Spelbrink, M, Sulman, H, Toonen, A, Wijnands, S, Kwa, D, Witte, E, Koopmans, P, Keuter, M, van der Ven, A, ter Hofstede, H, Dofferhoff, A, van Crevel, R, Albers, M, Bosch, M, Grintjes-Huisman, K, Zomer, B, Stelma, F, Rahamat-Langendoen, J, Burger, D, Richter, C, Gisolf, E, Hassing, R, ter Beest, G, van Bentum, P, Langebeek, N, Tiemessen, R, Swanink, C, van Lelyveld, S, Soetekouw, R, Hulshoff, N, van der Prijt, L, van der Swaluw, J, Bermon, N, Herpers, B, Veenendaal, D, Verhagen, D, van Wijk, M, Ziekenhuis, S, van Kasteren, M, Brouwer, A, de Wiel, B, Kuipers, M, Santegoets, R, van der Ven, B, Marcelis, J, Buiting, A, Kabel, P, Bierman, W, Scholvinck, H, Wilting, K, Stienstra, Y, Jonge, H, van der Meulen, P, de Weerd, D, Ludwig-Roukema, J, Niesters, H, Riezebos-Brilman, A, van Leer-Buter, C, Knoester, M, Hoepelman, A, Mudrikova, T, Ellerbroek, P, Oosterheert, J, Arends, J, Barth, R, Wassenberg, M, Schadd, E, van Elst-Laurijssen, D, van Oers-Hazelzet, E, Vervoort, S, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Peters, E, van Agtmael, M, Bomers, M, de Vocht, J, Heitmuller, M, Laan, L, Pettersson, A, Vandenbroucke-Grauls, C, Ang, C, Kinderziekenhuis, W, Geelen, S, Wolfs, T, Bont, L, Nauta, N, Bezemer, D, van Sighem, A, Boender, T, de Jong, A, Bergsma, D, Hoekstra, P, de Lang, A, Grivell, S, Jansen, A, Rademaker, M, Raethke, M, Meijering, R, Schnörr, S, de Groot, L, van den 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Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null

Abstract

Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.

Published
2024

25. Standard requirements for clinical very high energy electron and ultra high dose rate medical devices.

Author

Pensavalle, J. H., Di Martino, F., Cavalieri, A., Celentano, M., De Gregorio, A., Di Francesco, M., Franciosini, G., Galluzzo, L., Masturzo, L., Milluzzo, G., Montay-Gruel, P., Paiar, F., Pantaleoni, M., Patera, V., Pioli, S., Poortmans, P., Romano, F., Sarti, A., Subiel, A., and Vannozzi, A.

Subjects
RADIATION therapy equipment, TREATMENT effectiveness, CANCER treatment, RADIOTHERAPY, TUMOR treatment, RADIATION protection
Abstract

Very High-Energy Electrons (VHEE) present a promising innovation in radiation therapy (RT), particularly for the treatment of deep-seated tumors using Ultra High Dose Rate (UHDR) within the framework of FLASH-RT. VHEE offers significant advantages, such as improved tumor targeting, reduced treatment times, and potential utilization of the FLASH effect, which may minimize normal tissue toxicity. However, the lack of an international technical standard for VHEE systems, especially for UHDR applications, remains a critical challenge. Current standards for radiation therapy equipment, such as IEC 60601-2-1 and IEC 60601-2-64, do not encompass VHEE technology. This regulatory gap underscores the need for developing a structured international standard to ensure the basic safety and essential performance of VHEE medical devices. Addressing this challenge requires overcoming complex dose delivery issues, such as the interaction of multiple fields and beam conformality and incorporating novel techniques like broad beam or pencil beam scanning. Establishing comprehensive regulatory standards is essential to ensure patient safety, consistent treatment practices, and the successful clinical integration of VHEE systems. These standards must encompass design guidelines, radiation protection protocols, and integration with existing oncology practices. Collaborative research and development efforts are crucial to formulating evidence-based guidelines, fostering the safe and effective use of VHEE in clinical settings. By addressing these challenges, VHEE technology has the potential to revolutionize cancer therapy, particularly for deep-seated tumors, while enhancing therapeutic outcomes for patients. [ABSTRACT FROM AUTHOR]

Published
2024
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26. RESIDENCE AT HIGH ALTITUDE IS ASSOCIATED WITH LOWER CONVENTIONAL AND AMBULATORY BLOOD PRESSURE THAN LIVING AT SEA LEVEL IN THE GENERAL POPULATION OF PERU. HIGHCARE-LAPS STUDY

Author

Bilo, Grzegorz, primary, Villafuerte, Francisco C., additional, Zanotti, Lucia, additional, Soranna, Davide, additional, Nava, Sara, additional, Rusconi, Valentina, additional, Pengo, Martino F., additional, Croce, Alessandro, additional, Lombardi, Carolina, additional, Macarlupu, Jose Luis, additional, Bermudez, Daniela, additional, Sosa, Jose’ Manuel, additional, Carcamo, Cesar P., additional, Zambon, Antonella, additional, and Parati, Gianfranco, additional

Published
2024
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29. Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients

Author

Canzano, Paola, Brambilla, Marta, Porro, Benedetta, Cosentino, Nicola, Tortorici, Elena, Vicini, Stefano, Poggio, Paolo, Cascella, Andrea, Pengo, Martino F., Veglia, Fabrizio, Fiorelli, Susanna, Bonomi, Alice, Cavalca, Viviana, Trabattoni, Daniela, Andreini, Daniele, Omodeo Salè, Emanuela, Parati, Gianfranco, Tremoli, Elena, and Camera, Marina

Published
2021
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34. Preliminary study on the correlation between accelerated current and dose in water for an electron-based LINAC

Author

Franciosini, G., primary, Muraro, S., additional, De Gregorio, A., additional, De Simoni, M., additional, Di Francesco, M., additional, Di Martino, F., additional, Dong, Y., additional, Felici, G., additional, Galante, F., additional, Harold Pensavalle, J., additional, Marafini, M., additional, Mattei, I., additional, Muscato, A., additional, Pacitti, M., additional, Patera, V., additional, Sarti, A., additional, Schiavi, A., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Battistoni, G., additional

Published
2024
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38. A SMALL PORTABLE PROTOTYPE SECONDARY STANDARD CALORIMETER FOR FLASH RADIOTHERAPY REFERENCE DOSIMETRY WITH UHDR BEAMS

Author

Romano, F., primary, Milluzzo, G., additional, Capaccioli, S., additional, Del Sarto, D., additional, Di Martino, F., additional, Felici, G., additional, Giuliano, L., additional, Masturzo, L., additional, Montefiori, M., additional, Paiar, F., additional, Pensavalle, J.H., additional, Douralis, A., additional, Bass, G., additional, and Subiel, A., additional

Published
2023
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39. FLASH AND MINI-BEAM EFFECTS: TOWARDS A COMBINED APPROACH?

Author

Pensavalle, J.H., primary, Capaccioli, S., additional, Del Sarto, D., additional, Felici, G., additional, Masturzo, L., additional, Milluzzo, G., additional, Montefiori, M., additional, Paiar, F., additional, Prezado, Y., additional, Romano, F., additional, Ursino, S., additional, and Di Martino, F., additional

Published
2023
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41. THE ALLS CHAMBER: TECHNICAL ISSUES AND PRACTICAL SOLUTIONS FOR THE REALIZATION OF A NEW ONLINE DOSIMETER FOR FLASH RADIOTHERAPY

Author

Montefiori, M., primary, Baldini, L., additional, Bisogni, M.G., additional, Capaccioli, S., additional, Esther, C., additional, Del Sarto, D., additional, Felici, G., additional, Lucchesi, L., additional, Massa, M., additional, Masturzo, L., additional, Moggi, A., additional, Morrocchi, M., additional, Paiar, F., additional, Pensavalle, J.H., additional, Pilo, F., additional, Sgrò, C., additional, and Di Martino, F., additional

Published
2023
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42. PLANAR SILICON SENSORS FOR FLASH BEAMS MONITORING

Author

Ferro, A., primary, Camperi, A., additional, Vignali, M. Centis, additional, Del Sarto, D., additional, Deut, U., additional, Di Domenico, A., additional, Di Martino, F., additional, Fausti, F., additional, Giordanengo, S., additional, Villarreal, O.A. Martì, additional, Milian, F. Mas, additional, Masturzo, L., additional, Medina, E., additional, Olivares, D. Montalvan, additional, Montefiori, M., additional, Monti, V., additional, Pensavalle, J.H., additional, Vignati, A., additional, Cirio, R., additional, and Sacchi, R., additional

Published
2023
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45. DOSIMETRY AND MONITORING OF UHDR BEAMS WITH SILICON CARBIDE DETECTORS FOR FLASH RADIOTHERAPY

Author

Milluzzo, G., primary, Capaccioli, S., additional, Del Sarto, D., additional, Di Martino, F., additional, D’Oca, M.C., additional, Felici, G., additional, Marrale, M., additional, Masturzo, L., additional, Medina, E., additional, Montefiori, M., additional, Paiar, F., additional, Pensavalle, J.H., additional, Sangregorio, E., additional, Vignati, A., additional, Camarda, M., additional, and Romano, F., additional

Published
2023
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