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32 results on '"MENG Fanguo"'

1. Thermodynamic Calculation of Equilibrium Phases of K488 Alloy

Author

MENG Fanguo, KONG Shengguo, LI Wei, WU Jiantao, and LI Juntao

Subjects
K488 alloy, equilibrium phase diagram, precipitation amount, precipitation temperature, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract

The influence of equilibrium and alloy elements on the precipitation phases of K488 alloy was calculated and experimental analyzed by using Thermo-Calc thermodynamic calculation software. The results of calculation and experiment are shown that the alloy equilibrium phases are γ,γ',σ and carbides. In the alloy solidification process, Mo, Ti segregations are more serious. With the increase of C and Nb content, MC precipitation increased, but precipitation temperature decreased, the content of Ti is on the contrary. the increase of Al, Ti contents, γ' phase precipitations amount and precipitation temperature gradually increased. The content of Cr has most influence on the precipitation amount and precipitation temperature of the sigma phase. The calculation and experimental results have good consistency.

Published
2018
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5. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

Author

Zhou Haimeng, Meng Fanguo, Ou Wenbin, Jiao Yisheng, and Wang Aiyuan

Subjects
Ovarian Cancer, Tyrosine Kinases, coactivation, HSP90, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Ovarian cancer has the highest mortality rate of all gynecologic malignancy. The receptor tyrosine kinases (RTKs), including EGFR, ERBB2, PDGFR, VEGFR and MET, are activated in subsets of ovarian cancer, suggesting that these kinases might represent novel therapeutic targets. However, clinical trials have not or just partially shown benefit to ovarian cancers treated with EGFR, ERBB2, or PDGFR inhibitors. Despite multiple RTK activation in ovarian cancer pathogenesis, it is unclear whether transforming activity is dependent on an individual kinase oncoprotein or the coordinated activity of multiple kinases. We hypothesized that a coordinated network of multi-RTK activation is important for the tumorigenesis of ovarian cancers. Results Herein, we demonstrate co-activation of multiple RTKs (EGFR, ERBB2, ERBB4, MET and/or AXL) in individual ovarian cancer cell lines and primary tumors. We also show that coordinate inhibition of this multi-kinase signaling has substantially greater effect on ovarian cancer proliferation and survival, compared to inhibition of individual activated kinases. The inhibition of this multi-RTK signaling by HSP90 suppression results in profound pro-apoptotic and anti-proliferative effects, and is associated with the inactivation of RTK downstream PI3-K/AKT/mTOR and RAF/MAPK signaling. Conclusion These studies suggest that anti-multiple RTK strategy could be useful in the treatment of ovarian cancer.

Published
2011
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6. Effect of Homogenization Temperature on Microstructures of IN718C Alloy with Different Solidification Cooling Rates

Author

Yuan, Xiaofei, Meng, Fanguo, Zeng, Qiang, Li, Wei, Kong, Shengguo, Wu, Jiantao, Yan, Ping, Li, Juntao, Ott, Eric, editor, Liu, Xingbo, editor, Andersson, Joel, editor, Bi, Zhongnan, editor, Bockenstedt, Kevin, editor, Dempster, Ian, editor, Groh, Jon, editor, Heck, Karl, editor, Jablonski, Paul, editor, Kaplan, Max, editor, Nagahama, Daisuke, editor, and Sudbrack, Chantal, editor

Published
2018
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7. High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species

Author

Zeng, Nianyi, primary, Wu, Fan, additional, Lu, Junqi, additional, Li, Xiang, additional, Lin, Shaomei, additional, Zhou, Lang, additional, Wang, Zhongwei, additional, Wu, Guangyan, additional, Huang, Qingfa, additional, Zheng, Daowen, additional, Gao, Jie, additional, Wu, Shan, additional, Chen, Xiaojiao, additional, Chen, Muxuan, additional, Meng, Fanguo, additional, Shang, Haitao, additional, He, Yan, additional, Chen, Peng, additional, Wei, Hong, additional, Li, Zhuang, additional, and Zhou, Hongwei, additional

Published
2023
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9. Supplementary Figure Legends from Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Author

Chen, Weicai, primary, Kuang, Ye, primary, Qiu, Hai-Bo, primary, Cao, Zhifa, primary, Tu, Yuqing, primary, Sheng, Qing, primary, Eilers, Grant, primary, He, Quan, primary, Li, Hai-Long, primary, Zhu, Meijun, primary, Wang, Yuexiang, primary, Zhang, Rongqing, primary, Wu, Yeqing, primary, Meng, Fanguo, primary, Fletcher, Jonathan A., primary, and Ou, Wen-Bin, primary

Published
2023
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10. Data from Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Author

Chen, Weicai, primary, Kuang, Ye, primary, Qiu, Hai-Bo, primary, Cao, Zhifa, primary, Tu, Yuqing, primary, Sheng, Qing, primary, Eilers, Grant, primary, He, Quan, primary, Li, Hai-Long, primary, Zhu, Meijun, primary, Wang, Yuexiang, primary, Zhang, Rongqing, primary, Wu, Yeqing, primary, Meng, Fanguo, primary, Fletcher, Jonathan A., primary, and Ou, Wen-Bin, primary

Published
2023
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11. SFigure 1 from Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Author

Chen, Weicai, primary, Kuang, Ye, primary, Qiu, Hai-Bo, primary, Cao, Zhifa, primary, Tu, Yuqing, primary, Sheng, Qing, primary, Eilers, Grant, primary, He, Quan, primary, Li, Hai-Long, primary, Zhu, Meijun, primary, Wang, Yuexiang, primary, Zhang, Rongqing, primary, Wu, Yeqing, primary, Meng, Fanguo, primary, Fletcher, Jonathan A., primary, and Ou, Wen-Bin, primary

Published
2023
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12. SFigure 2 from Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Author

Chen, Weicai, primary, Kuang, Ye, primary, Qiu, Hai-Bo, primary, Cao, Zhifa, primary, Tu, Yuqing, primary, Sheng, Qing, primary, Eilers, Grant, primary, He, Quan, primary, Li, Hai-Long, primary, Zhu, Meijun, primary, Wang, Yuexiang, primary, Zhang, Rongqing, primary, Wu, Yeqing, primary, Meng, Fanguo, primary, Fletcher, Jonathan A., primary, and Ou, Wen-Bin, primary

Published
2023
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18. Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

Author

Xu, Kaiyu, primary, Gao, Xuxuan, additional, Xia, Genghong, additional, Chen, Muxuan, additional, Zeng, Nianyi, additional, Wang, Shan, additional, You, Chao, additional, Tian, Xiaolin, additional, Di, Huiling, additional, Tang, Wenli, additional, Li, Pan, additional, Wang, Huidi, additional, Zeng, Xiuli, additional, Tan, Chuhong, additional, Meng, Fanguo, additional, Li, Hailong, additional, He, Yan, additional, Zhou, Hongwei, additional, and Yin, Jia, additional

Published
2021
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20. Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Author

Chen, Weicai, primary, Kuang, Ye, additional, Qiu, Hai-Bo, additional, Cao, Zhifa, additional, Tu, Yuqing, additional, Sheng, Qing, additional, Eilers, Grant, additional, He, Quan, additional, Li, Hai-Long, additional, Zhu, Meijun, additional, Wang, Yuexiang, additional, Zhang, Rongqing, additional, Wu, Yeqing, additional, Meng, Fanguo, additional, Fletcher, Jonathan A., additional, and Ou, Wen-Bin, additional

Published
2017
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24. HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

Author

Ou, Wen-Bin, primary, Zhu, Jiaqing, additional, Eilers, Grant, additional, Li, Xuhui, additional, Kuang, Ye, additional, Liu, Li, additional, Mariño-Enríquez, Adrián, additional, Yan, Ziqin, additional, Li, Hailong, additional, Meng, Fanguo, additional, Zhou, Haimeng, additional, Sheng, Qing, additional, and Fletcher, Jonathan A., additional

Published
2015
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