Search

Your search keyword '"MEO, Marianna"' showing total 125 results
Start Over Author "MEO, Marianna"
125 results on '"MEO, Marianna"'

1. High-resolution mapping of reentrant atrial tachycardias: Relevance of low bipolar voltage

Author

Ramirez, F. Daniel, Meo, Marianna, Dallet, Corentin, Krisai, Philipp, Vlachos, Konstantinos, Frontera, Antonio, Takigawa, Masateru, Nakatani, Yosuke, Nakashima, Takashi, André, Clémentine, Kamakura, Tsukasa, Takagi, Takamitsu, Carapezzi, Aline, Tixier, Romain, Chauvel, Rémi, Cheniti, Ghassen, Duchateau, Josselin, Pambrun, Thomas, Sacher, Frédéric, Hocini, Mélèze, Haïssaguerre, Michel, Jaïs, Pierre, Dubois, Rémi, and Derval, Nicolas

Published
2023
Full Text
View/download PDF

2. Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes

Author

Roney, Caroline H, Pashaei, Ali, Meo, Marianna, Dubois, Remi, Boyle, Patrick M, Trayanova, Natalia A, Cochet, Hubert, Niederer, Steven A, and Vigmond, Edward J

Subjects
Physics - Medical Physics, Quantitative Biology - Tissues and Organs
Abstract

Integrating spatial information about atrial physiology and anatomy in a single patient from multimodal datasets, as well as generalizing these data across patients, requires a common coordinate system. In the atria, this is challenging due to the complexity and variability of the anatomy. We aimed to develop and validate a universal atrial coordinate system for the following applications: combination and assessment of multimodal data; comparison of spatial data across patients; 2D visualization; and construction of patient specific geometries to test mechanistic hypotheses. Left and right atrial LGE-MRI data were segmented and meshed. Two coordinates were calculated for each atrium by solving Laplace's equation, with boundary conditions assigned using five landmark points. The coordinate system was used to map spatial information between atrial meshes, including atrial anatomic structures and fibre directions from a reference geometry. Average error in point transfer from a source mesh to a destination mesh and back again was less than 6% of the average mesh element edge length. Scalar mapping from electroanatomic to MRI geometries was compared to an affine registration technique (mean difference in bipolar voltage: <10% of voltage range). Patient specific meshes were constructed using UACs and phase singularity density maps from arrhythmia simulations were visualised in 2D. We have developed a universal atrial coordinate system allowing automatic registration of imaging and electroanatomic mapping data, 2D visualisation, and patient specific model creation, using just five landmark points.

Published
2018

3. Sinus node exit, crista terminalis conduction, interatrial connection, and wavefront collision: Key features of human atrial activation in sinus rhythm

Author

Pambrun, Thomas, Derval, Nicolas, Duchateau, Josselin, Ramirez, F. Daniel, Chauvel, Rémi, Tixier, Romain, Marchand, Hugo, Bouyer, Benjamin, Welte, Nicolas, André, Clémentine, Nakashima, Takashi, Nakatani, Yosuke, Kamakura, Tsukasa, Takagi, Takamitsu, Krisai, Philipp, Ascione, Ciro, Balbo, Conrado, Cheniti, Ghassen, Vlachos, Konstantinos, Bourier, Félix, Takigawa, Masateru, Kitamura, Takeshi, Frontera, Antonio, Meo, Marianna, Denis, Arnaud, Sacher, Frédéric, Hocini, Mélèze, Jaïs, Pierre, and Haïssaguerre, Michel

Published
2022
Full Text
View/download PDF

4. Automatic identification of ablation targets in persistent atrial fibrillation: Initial experience with a new mapping tool.

Author

Lațcu, Decebal Gabriel, Enache, Bogdan, Lerebours, Chloe, Milanese, Sofia, Benhenda, Nazih, Canepa, Silvia, Kingston, Amanda, Meo, Marianna, and Saoudi, Nadir

Subjects
PULMONARY veins, HEART function tests, AMBULATORY electrocardiography, DESCRIPTIVE statistics, ATRIAL fibrillation, CATHETER ablation, ALGORITHMS
Abstract

Introduction: Strategies beyond pulmonary vein isolation (PVI) in persistent atrial fibrillation (persAF) are debated. A novel mapping tool provides algorithmic detection of ablation targets based on electrogram (EGM) properties specific to stable localized rotational activations. Methods: The mapping tool was used on 31 patients (20 de novo). The algorithm was used to optimize PVI line placement and guide additional ablations. Targets were detected by calculating local cycle length (L‐CL) and local spread of activation within that L‐CL (Duty Cycle; DC) for EGMs with consistent morphology and activation. At least two left atrial (LA) maps (pre‐PVI and post‐PVI) were acquired in atrial fibrillation (AF) in all patients (except those with AF termination during PVI). Extra‐pulmonary vein (PV) targets were compared between the two LA maps in each patient. Follow‐up included Holter monitoring every 3 months. Results: Patients had a median of 3 extra‐PV drivers/targets. The majority (81%) were localized in the same areas between the two LA maps. All patients had progressive AF organization demonstrated by global activation slowing: histogram peak L‐CL increased from 162 to 171 ms (post‐PVI; p =.0003) than to 175 ms (posttarget ablation; p =.04). Moreover, L‐CL dispersion was reduced by ablation; in 50% their values tended to cluster around two dominant cycles. In de novo patients AF terminated to sinus rhythm or atrial tachycardia (AT) within 48 h postprocedure in 88% of cases, and at 18 months mean follow‐up recurrence occurred in only five (25%) patients (three persAF, two AT). There were no complications. Conclusion: The algorithmic detection of EGMs consistent with localized reentry during sequential mapping of persAF provided reproducible targets for ablation. This allowed personalized PVI and limited, highly‐selective, extra‐PV ablation. Results of this initial experience included progressive organization of AF with ablation and a low recurrence rate after a single procedure. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. High-resolution mapping of reentrant atrial tachycardias: Relevance of low bipolar voltage

Author

Ramirez, F. Daniel, primary, Meo, Marianna, additional, Dallet, Corentin, additional, Krisai, Philipp, additional, Vlachos, Konstantinos, additional, Frontera, Antonio, additional, Takigawa, Masateru, additional, Nakatani, Yosuke, additional, Nakashima, Takashi, additional, André, Clémentine, additional, Kamakura, Tsukasa, additional, Takagi, Takamitsu, additional, Carapezzi, Aline, additional, Tixier, Romain, additional, Chauvel, Rémi, additional, Cheniti, Ghassen, additional, Duchateau, Josselin, additional, Pambrun, Thomas, additional, Sacher, Frédéric, additional, Hocini, Mélèze, additional, Haïssaguerre, Michel, additional, Jaïs, Pierre, additional, Dubois, Rémi, additional, and Derval, Nicolas, additional

Published
2022
Full Text
View/download PDF

15. Relation of surface T-wave to vulnerability to ventricular fibrillation in explanted structurally normal hearts

Author

Meo, Marianna, Meo, Marianna, Bonizzi, Pietro, Bear, Laura, Cluitmans, Matthijs, Abell, Emma, Haïssaguerre, Michel, Bernus, Olivier, Dubois, Rémi, Meo, Marianna, Meo, Marianna, Bonizzi, Pietro, Bear, Laura, Cluitmans, Matthijs, Abell, Emma, Haïssaguerre, Michel, Bernus, Olivier, and Dubois, Rémi

Abstract

Introduction: Body surface characterization of repolarization gradient substrates for ventricular fibrillation (VF) is still poor. We investigated if VF propensity can be assessed from surface T-wave in an ex-vivo model of purely electrical repolarization dispersion. Methods: To create repolarization gradients, dofetilide and/or pinacidil were separately infused in N=7 isolated pig hearts in a human-shaped torso tank. At each drug state, VF inducibility was quantified by the vulnerability window (VW), i.e. the interval during which VF was triggered by S1 (atrium) S2 (ventricle) stimulation. T-wave duration (the peak-to-end interval, T-PEAK-T-END), and shape, i.e., symmetry (the ratio of the areas under the peak-to-end and onset-to-peak frames, Asy), and flatness (kurtosis, Kurt) were computed from 256 tank potentials. We fitted a linear mixed-effect (LMM) model to link T-wave markers (fixed effects) with VW (response), with random effects on drug states and hearts. Results: VF was induced in 14/23 drug states from at least one ventricle. In vulnerable substrates (higher VW), T-waves were longer (T-PEAK-T-END, p=0.0004), less symmetric (Asy, p

Published
2020

18. Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps

Author

Meo, Marianna, primary, Denis, Arnaud, additional, Sacher, Frédéric, additional, Duchâteau, Josselin, additional, Cheniti, Ghassen, additional, Puyo, Stéphane, additional, Bear, Laura, additional, Jaïs, Pierre, additional, Hocini, Mélèze, additional, Haïssaguerre, Michel, additional, Bernus, Olivier, additional, and Dubois, Rémi, additional

Published
2020
Full Text
View/download PDF

22. Analysis of Signal-Averaged Electrocardiogram Performance for Body Surface Recordings

Author

Tan, Nolwenn, Bear, Laura, Potse, Mark, Puyo, Stéphane, Meo, Marianna, Dubois, Rémi, Potse, Mark, Programme fédérateur Agriculture et Développement Durable - Innovations agro-écologiques et organisationnelles pour une Gestion Durable de la Qualité de l'Eau dans des régions de monoculture à forts niveaux d'intrants phytosanitaires - - GeDuQue2005 - ANR-05-PADD-0010 - ADD - VALID, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the French National Research Agency, grant reference ANR-10-IAHU04-LIRYC. This work was granted access to HPC resources of CINES under GENCI allocation 2019-A0050307379, and ANR-05-PADD-0010,GeDuQue,Innovations agro-écologiques et organisationnelles pour une Gestion Durable de la Qualité de l'Eau dans des régions de monoculture à forts niveaux d'intrants phytosanitaires(2005)

Subjects
0206 medical engineering, [MATH] Mathematics [math], 02 engineering and technology, [MATH]Mathematics [math], 020601 biomedical engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019
Full Text
View/download PDF

23. Trigger and Substrate Share A Common Location In Human VF

Author

HAÏSSAGUERRE, Michel, HOCINI, Meleze, PUYO, Stéphane, CHENITI, Ghassen, DUCHATEAU, Josselin, DENIS, Arnaud, COCHET, Hubert, MEO, Marianna, KITAMURA, Takeshi, TAKIGAWA, Masateru, FRONTERA, Antonio, VLACHOS, Konstantinos George, MASSOULLIÉ, Grégoire, LAM, Anna, BOURIER, Felix, PAMBRUN, Thomas, WELTE, Nicolas, DERVAL, Nicolas, AMRAOUI, Sana, KLOTZ, Nicolas, SACHER, Fréderic, BORDACHAR, Pierre, PLOUX, Sylvain, RITTER, Philippe, JAÏS, Pierre, VIGMOND, Edward J., POTSE, Mark, WALTON, Richard D., DUBOIS, Rémi, BERNUS, Olivier, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Hôpital Haut-Lévêque [CHU Bordeaux], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], and Potse, Mark

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience; Background: The mechanisms of ventricular fibrillation (VF) are classically distinguished in triggers versus substrate. However, their respective location in patients with structural heart disease (SHD) has not been investigated.Objective: To precisely locate trigger and substrate in patients presenting spontaneous VFMethods: Within a 5 year inclusion period, we investigated 14 patients (57±10 years) presenting a documented spontaneous episode of VF (lasting 16± 8s before cardioversion) associated with ischemic heart disease in 8, cardiomyopathy in 4 , and Brugada syndrome in 2. VF mapping was performed using multielectrode intracardiac and body-surface recordings. The VF trigger was located at the site of earliest ventricular activation. Reentrant drivers were identified during VF using phase mapping and confirmed by the demonstration of sequential circular activation of local electrograms. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented electrograms (≥70ms).Results:The first beat of VF originated from Purkinje network in 8 and ventricular myocardium in 6; with the earliest endocardial electrogram preceding the QRS onset by 54 ±12ms . While myocardial triggers showed a single breakthrough on body surface mapping, Purkinje triggers were associated with simultaneous emergence of multiple breakthroughs. The transition from a focal trigger to a reentrant activity occurred at a median of 4 VF cycles [range: 2-7 cycles]. Mapping at the trigger sites showed low voltage fragmented electrograms during sinus rhythm in 12/14 patients.During VF, a driver region was consistently found to colocalize with the site of triggers in 12 patients, accounting for 34±10% of the total driver activities Catheter ablation was performed at these “trigger-driver” regions resulting in abolition of abnormal electrograms and arrhythmia-free outcome in 10 of 12 patients at 18±15 months follow up.Conclusion: Purkinje focal activity may show several ventricular exit sites. In most patients with SHD, the sites of VF triggers are intertwined with the maintaining substrate, providing a dual mechanistic target for interventional treatment.

Published
2018

24. Distinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase

Author

Haïssaguerre, Michel, Duchateau, Josselin, Cheniti, Ghassen, Puyo, Stéphane, Denis, Arnaud, Cochet, Hubert, Meo, Marianna, Kitamura, Takeshi, Takigawa, Masateru, Frontera, Antonio, Vlachos, Konstantinos George, Massoullié, Grégoire, Lam, Anna, Bourier, Felix, Pambrun, Thomas, Welte, Nicolas, Derval, Nicolas, Amraoui, Sana, Klotz, Nicolas, Sacher, Fréderic, Bordachar, Pierre, Ploux, Sylvain, Ritter, Philippe, Jaïs, Pierre, Vigmond, Edward J., Potse, Mark, Walton, Richard D., Dubois, Rémi, Bernus, Olivier, Hocini, Meleze, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], University Hospital of Ioannina, Hôpital de l'Ile, Université de Bordeaux (UB), Hôpital Haut-Lévêque [CHU Bordeaux], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience; Background: Ventricular fibrillation (VF) progresses rapidly from an initial organized stage to chaotic fibrillation. The characteristics of initial drivers, that may be critical for therapeutic interventions, have not been investigated.Objective: To characterize the initial drivers of Human VFMethods: We evaluated 51 patients (44±10 years) who survived VF associated with ischemic heart disease in 15, cardiomyopathy in 14 and Brugada syndrome in 22. VF was mapped by intracardiac and body-surface recordings to analyze spatial organization, cycle lengths (CL), and drivers at the origin of wavefronts. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented signals (≥70ms).Results: We mapped 69 episodes of spontaneous (n=12) or induced (n=57) VF for 17±10 s. The VF CL decreased from 208±28 to 172±25 ms (p

Published
2018

25. An Automated Platform to Standardize Position in the Left Atrium and Map Electrophysiological Data

Author

Meo, Marianna, primary, Duchâteau, Josselin, additional, Bayer, Jason, additional, Pambrun, Thomas, additional, Roney, Caroline, additional, Vigmond, Edward, additional, Derval, Nicolas, additional, Denis, Arnaud, additional, Jaïs, Pierre, additional, Hocini, Mélèze, additional, Haïssaguerre, Michel, additional, and Dubois, Remi, additional

Published
2019
Full Text
View/download PDF

28. Mapping and Ablation of Idiopathic Ventricular Fibrillation

Author

Cheniti, Ghassen, primary, Vlachos, Konstantinos, additional, Meo, Marianna, additional, Puyo, Stephane, additional, Thompson, Nathaniel, additional, Denis, Arnaud, additional, Duchateau, Josselin, additional, Takigawa, Masateru, additional, Martin, Claire, additional, Frontera, Antonio, additional, Kitamura, Takeshi, additional, Lam, Anna, additional, Bourier, Felix, additional, Klotz, Nicolas, additional, Derval, Nicolas, additional, Sacher, Frederic, additional, Jais, Pierre, additional, Dubois, Remi, additional, Hocini, Meleze, additional, and Haissaguerre, Michel, additional

Published
2018
Full Text
View/download PDF

32. Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms

Author

RONEY, Caroline, BAYER, Jason, ZAHID, Sohail, MEO, Marianna, BOYLE, Patrick, TRAYANOVA, Natalia, HAÏSSAGUERRE, Michel, DUBOIS, Rémi, COCHET, Hubert, VIGMOND, Edward, BOYLE, Patrick M.J., IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Johns Hopkins University (JHU), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
0301 basic medicine, Patient-Specific Modeling, Pathology, medicine.medical_treatment, Action Potentials, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, Fibrosis, Heart Rate, Atrial Fibrillation, medicine.diagnostic_test, Models, Cardiovascular, Atrial fibrillation, Signal Processing, Computer-Assisted, Reentry, Mechanics, Supplement: Reviews, Ablation, Atrial Function, Prognosis, Magnetic Resonance Imaging, Reentrancy, cardiovascular system, [SDV.IB]Life Sciences [q-bio]/Bioengineering, medicine.symptom, Cardiology and Cardiovascular Medicine, Electrophysiologic Techniques, Cardiac, medicine.medical_specialty, Catheter ablation, macromolecular substances, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Non-invasive electrocardiographic imaging, Predictive Value of Tests, Physiology (medical), medicine, Humans, Heart Atria, Fibrillation, Electrogram fractionation, business.industry, Phase singularity mapping, Magnetic resonance imaging, Atrial fibrosis, medicine.disease, 030104 developmental biology, Computer modelling, business
Abstract

Aims Catheter ablation is an effective technique for terminating atrial arrhythmia. However, given a high atrial fibrillation (AF) recurrence rate, optimal ablation strategies have yet to be defined. Computer modelling can be a powerful aid but modelling of fibrosis, a major factor associated with AF, is an open question. Several groups have proposed methodologies based on imaging data, but no comparison to determine which methodology best corroborates clinically observed reentrant behaviour has been performed. We examined several methodologies to determine the best method for capturing fibrillation dynamics. Methods and results Patient late gadolinium-enhanced magnetic resonance imaging data were transferred onto a bilayer atrial computer model and used to assign fibrosis distributions. Fibrosis was modelled as conduction disturbances (lower conductivity, edge splitting, or percolation), transforming growth factor-β1 ionic channel effects, myocyte-fibroblast coupling, and combinations of the preceding. Reentry was induced through pulmonary vein ectopy and the ensuing rotor dynamics characterized. Non-invasive electrocardiographic imaging data of the patients in AF was used for comparison. Electrograms were computed and the fractionation durations measured over the surface. Edge splitting produced more phase singularities from wavebreaks than the other representations. The number of phase singularities seen with percolation was closer to the clinical values. Addition of fibroblast coupling had an organizing effect on rotor dynamics. Simple tissue conductivity changes with ionic changes localized rotors over fibrosis which was not observed with clinical data. Conclusion The specific representation of fibrosis has a large effect on rotor dynamics and needs to be carefully considered for patient specific modelling.

Published
2016
Full Text
View/download PDF

35. Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes

Author

Sorrentino, Andrea, primary, Borghetti, Giulia, additional, Zhou, Yu, additional, Cannata, Antonio, additional, Meo, Marianna, additional, Signore, Sergio, additional, Anversa, Piero, additional, Leri, Annarosa, additional, Goichberg, Polina, additional, Qanud, Khaled, additional, Jacobson, Jason T., additional, Hintze, Thomas H., additional, and Rota, Marcello, additional

Published
2017
Full Text
View/download PDF

39. Myocyte repolarization modulates myocardial function in aging dogs

Author

Sorrentino, Andrea, primary, Signore, Sergio, additional, Qanud, Khaled, additional, Borghetti, Giulia, additional, Meo, Marianna, additional, Cannata, Antonio, additional, Zhou, Yu, additional, Wybieralska, Ewa, additional, Luciani, Marco, additional, Kannappan, Ramaswamy, additional, Zhang, Eric, additional, Matsuda, Alex, additional, Webster, Andrew, additional, Cimini, Maria, additional, Kertowidjojo, Elizabeth, additional, D'Alessandro, David A., additional, Wunimenghe, Oriyanhan, additional, Michler, Robert E., additional, Royer, Christopher, additional, Goichberg, Polina, additional, Leri, Annarosa, additional, Barrett, Edward G., additional, Anversa, Piero, additional, Hintze, Thomas H., additional, and Rota, Marcello, additional

Published
2016
Full Text
View/download PDF

40. Spatio-temporal characterization of the surface electrocardiogram for catheter ablation outcome prediction in persistent atrial fibrillation

Author

Meo, Marianna, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe BIOMED, Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis, Vicente Zarzoso, and Olivier Meste

Subjects
Fibrillation auriculaire, [SPI.OTHER]Engineering Sciences [physics]/Other, PCA, Spatio-temporal variability, Ablation, Électrocardiogramme, Atrial fibrillation, Variabilité spatio-temporelle, Electrocardiogram
Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, and one of the main causes of stroke. Yet its thorough characterization and treatment remain an open issue. Despite the increasing popularity of the radiofrequency catheter ablation (CA) therapy, very little is known about its impact on heart substrate, leading to rather uncertain success rates. This calls for advanced signal processing tools for quantitatively assessing CA outcome. The surface 12-lead electrocardiogram (ECG), a noninvasive and cost-effective cardiac activity recording modality, provides valuable information about AF. However, some issues affect most of the standard CA outcome predictors, e.g., manual computation and limited single-lead perspective. This thesis aims at explicitly exploiting the ECG’s multilead character through multivariate decomposition tools, so as to enhance the role of some ECG features as CA outcome predictors. Fibrillatory wave amplitude is correlated with CA success in a multilead framework through principal component analysis (PCA). Multivariate approaches also enhance AF spatiotemporal variability measured on the ECG (e.g., weighted PCA, nonnegative matrix factorization), evidencing that the less repetitive the AF pattern, the less likely CA success. Information theory also quantifies interlead similarity between AF patterns, and is linked with CA outcome in a multilead framework. Another perspective focuses on the ventricular response as reflected on heart rate variability (HRV). Point process modeling can highlight certain HRV properties typical of AF in a parametric probabilistic context, helping AF pattern recognition.; Responsable d’un quart des accidents vasculaires cérébraux, la fibrillation auriculaire (FA) est l’arythmie cardiaque la plus répandue. La thérapie d’ablation par cathéter (CA) est de plus en plus utilisée pour traiter la FA, mais ses effets sur le substrat cardiaque ne sont pas suffisamment compris, d’où un taux de réussite très variable. L’électrocardiogramme (ECG) à 12 voies représente un outil non invasif peu coûteux pour caractériser la FA à partir de l’activité électrique du cœur. Cependant, les prédicteurs classiques de l’issue de la CA présentent plusieurs inconvénients, notamment leur calcul manuel sur une seule voie de l’ECG. Cette thèse exploite explicitement le caractère multi-capteur de l’ECG au moyen de techniques de décomposition multivariées, démontrant qu’elles peuvent améliorer la puissance prédictive de certaines propriétés de l’ECG dans le cadre de la CA. L’amplitude des ondes fibrillatoires est corrélée avec le résultat de la CA, et traitée par une méthode multi-capteur basée sur l’analyse en composantes principales (PCA). Des variantes comme la PCA pondérée (WPCA) et la factorisation en matrices non négatives (NMF) peuvent aussi quantifier la variabilité spatio-temporelle de la FA sur l’ECG. La théorie de l’information permet également d’estimer le niveau de corrélation entre les voies de l’ECG, mis en relation avec le résultat de la CA grâce à des approches multi-capteurs. Enfin, une dernière ligne de recherche concerne la réponse ventriculaire manifestée sur la variabilité cardiaque. L’approche paramétrique de processus ponctuel est capable de souligner certaines propriétés de cette variabilité, améliorant ainsi la caractérisation de la FA.

Published
2013

41. Caractérisation spatio-temporelle de l’électrocardiogramme de surface pour prédire le résultat de l’ablation par cathéter de la fibrillation atriale persistante

Author

Meo, Marianna, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe BIOMED, Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis, Vicente Zarzoso, and Olivier Meste

Subjects
Fibrillation auriculaire, [SPI.OTHER]Engineering Sciences [physics]/Other, PCA, Spatio-temporal variability, Ablation, Électrocardiogramme, Atrial fibrillation, Variabilité spatio-temporelle, Electrocardiogram
Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, and one of the main causes of stroke. Yet its thorough characterization and treatment remain an open issue. Despite the increasing popularity of the radiofrequency catheter ablation (CA) therapy, very little is known about its impact on heart substrate, leading to rather uncertain success rates. This calls for advanced signal processing tools for quantitatively assessing CA outcome. The surface 12-lead electrocardiogram (ECG), a noninvasive and cost-effective cardiac activity recording modality, provides valuable information about AF. However, some issues affect most of the standard CA outcome predictors, e.g., manual computation and limited single-lead perspective. This thesis aims at explicitly exploiting the ECG’s multilead character through multivariate decomposition tools, so as to enhance the role of some ECG features as CA outcome predictors. Fibrillatory wave amplitude is correlated with CA success in a multilead framework through principal component analysis (PCA). Multivariate approaches also enhance AF spatiotemporal variability measured on the ECG (e.g., weighted PCA, nonnegative matrix factorization), evidencing that the less repetitive the AF pattern, the less likely CA success. Information theory also quantifies interlead similarity between AF patterns, and is linked with CA outcome in a multilead framework. Another perspective focuses on the ventricular response as reflected on heart rate variability (HRV). Point process modeling can highlight certain HRV properties typical of AF in a parametric probabilistic context, helping AF pattern recognition.; Responsable d’un quart des accidents vasculaires cérébraux, la fibrillation auriculaire (FA) est l’arythmie cardiaque la plus répandue. La thérapie d’ablation par cathéter (CA) est de plus en plus utilisée pour traiter la FA, mais ses effets sur le substrat cardiaque ne sont pas suffisamment compris, d’où un taux de réussite très variable. L’électrocardiogramme (ECG) à 12 voies représente un outil non invasif peu coûteux pour caractériser la FA à partir de l’activité électrique du cœur. Cependant, les prédicteurs classiques de l’issue de la CA présentent plusieurs inconvénients, notamment leur calcul manuel sur une seule voie de l’ECG. Cette thèse exploite explicitement le caractère multi-capteur de l’ECG au moyen de techniques de décomposition multivariées, démontrant qu’elles peuvent améliorer la puissance prédictive de certaines propriétés de l’ECG dans le cadre de la CA. L’amplitude des ondes fibrillatoires est corrélée avec le résultat de la CA, et traitée par une méthode multi-capteur basée sur l’analyse en composantes principales (PCA). Des variantes comme la PCA pondérée (WPCA) et la factorisation en matrices non négatives (NMF) peuvent aussi quantifier la variabilité spatio-temporelle de la FA sur l’ECG. La théorie de l’information permet également d’estimer le niveau de corrélation entre les voies de l’ECG, mis en relation avec le résultat de la CA grâce à des approches multi-capteurs. Enfin, une dernière ligne de recherche concerne la réponse ventriculaire manifestée sur la variabilité cardiaque. L’approche paramétrique de processus ponctuel est capable de souligner certaines propriétés de cette variabilité, améliorant ainsi la caractérisation de la FA.

Published
2013

42. Non-invasive prediction of catheter ablation outcome in persistent atrial fibrillation: exploiting the spatial variability of the f-wave amplitude in the surface ECG

Author

Meo, Marianna, Zarzoso, Vicente, Meste, Olivier, Latcu, Decebal Gabriel, Saoudi, Nadir, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe SIGNAL, Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre Hospitalier Princesse Grace de Monaco (CHPG), Monaco, and ANR-10-JCJC-0303,PERSIST,Caractérisation multidimensionnelle du signal électrocardiographique pour prédire le succès de la thérapie d'ablation par radiofréquence chez les patients souffrant de fibrillation auriculaire persistante(2010)

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB]Life Sciences [q-bio]/Bioengineering, ComputingMilieux_MISCELLANEOUS, GeneralLiterature_MISCELLANEOUS
Abstract

1st Prize in Poster Competition; International audience

Published
2011

43. Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm

Author

Meo, Marianna, primary, Meste, Olivier, additional, Signore, Sergio, additional, Sorrentino, Andrea, additional, Cannata, Antonio, additional, Zhou, Yu, additional, Matsuda, Alex, additional, Luciani, Marco, additional, Kannappan, Ramaswamy, additional, Goichberg, Polina, additional, Leri, Annarosa, additional, Anversa, Piero, additional, and Rota, Marcello, additional

Published
2016
Full Text
View/download PDF

44. Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy

Author

Signore, Sergio, primary, Sorrentino, Andrea, additional, Borghetti, Giulia, additional, Cannata, Antonio, additional, Meo, Marianna, additional, Zhou, Yu, additional, Kannappan, Ramaswamy, additional, Pasqualini, Francesco, additional, O'Malley, Heather, additional, Sundman, Mark, additional, Tsigkas, Nikolaos, additional, Zhang, Eric, additional, Arranto, Christian, additional, Mangiaracina, Chiara, additional, Isobe, Kazuya, additional, Sena, Brena F., additional, Kim, Junghyun, additional, Goichberg, Polina, additional, Nahrendorf, Matthias, additional, Isom, Lori L., additional, Leri, Annarosa, additional, Anversa, Piero, additional, and Rota, Marcello, additional

Published
2015
Full Text
View/download PDF

46. Abstract 17272: Ionic Current Remodeling Delays the Electrical Recovery of the Senescent Heart

Author

Signore, Sergio, primary, Borghetti, Giulia, additional, Kannappan, Ramaswamy, additional, Sorrentino, Andrea, additional, Cannata, Antonio, additional, Meo, Marianna, additional, Zhou, Yu, additional, Mangiaracina, Chiara, additional, Alesi, Nicola, additional, Sena, Brena F, additional, Nahrendorf, Matthias, additional, Goichberg, Polina, additional, Leri, Annarosa, additional, Anversa, Piero, additional, and Rota, Marcello, additional

Published
2014
Full Text
View/download PDF

48. Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes.

Author

Sorrentino, Andrea, Borghetti, Giulia, Yu Zhou, Cannata, Antonio, Meo, Marianna, Signore, Sergio, Anversa, Piero, Leri, Annarosa, Goichberg, Polina, Qanud, Khaled, Jacobson, Jason T., Hintze, Thomas H., and Rota, Marcello

Subjects
HYPERGLYCEMIA, HOMEOSTASIS
Abstract

Diabetes and other metabolic conditions characterized by elevated blood glucose constitute important risk factors for cardiovascular disease. Hyperglycemia targets myocardial cells rendering ineffective mechanical properties of the heart, but cellular alterations dictating the progressive deterioration of cardiac function with metabolic disorders remain to be clarified. In the current study, we examined the effects of hyperglycemia on cardiac function and myocyte physiology by employing mice with high blood glucose induced by administration of streptozotocin, a compound toxic to insulin-producing β-cells. We found that hyperglycemia initially delayed the electrical recovery of the heart, whereas cardiac function became defective only after ~2 mo with this condition and gradually worsened with time. Prolonged hyperglycemia was associated with increased chamber dilation, thinning of the left ventricle (LV), and myocyte loss. Cardiomyocytes from hyperglycemic mice exhibited defective Ca2+ transients before the appearance of LV systolic defects. Alterations in Ca2+ transients involved enhanced spontaneous Ca2+ releases from the sarcoplasmic reticulum (SR), reduced cytoplasmic Ca2+ clearance, and declined SR Ca2+ load. These defects have important consequences on myocyte contraction, relaxation, and mechanisms of rate adaptation. Collectively, our data indicate that hyperglycemia alters intracellular Ca2+ homeostasis in cardiomyocytes, hindering contractile activity and contributing to the manifestation of the diabetic cardiomyopathy. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results