1. High resolution genotyping of Aspergillus fumigatus isolates recovered from chronically colonised patients with cystic fibrosis
- Author
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Lies M. E. Vanhee, Jean-Philippe Bouchara, Françoise Symoens, Tom Coenye, Hans Nelis, Universiteit Gent = Ghent University [Belgium] (UGENT), Mycology [Brussels], Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), and This research was financially supported by the Belgian Science Policy (contract C3/00/19), by the BOF of Ghent University and FWO-Vlaanderen.
- Subjects
Pancreatic disease ,Cystic Fibrosis ,[SDV]Life Sciences [q-bio] ,Cystic fibrosis ,Aspergillus fumigatus ,MESH: Genotype ,Cystic Fibrosis Patient ,Medical microbiology ,Short Tandem Repeat Locus ,Genotype ,MESH: DNA Fingerprinting ,Medicine and Health Sciences ,Cluster Analysis ,DNA, Fungal ,Mycological Typing Techniques ,0303 health sciences ,Molecular Epidemiology ,biology ,General Medicine ,Fungi imperfecti ,High Discriminatory Power ,Infectious Diseases ,MESH: DNA, Fungal / genetics ,MESH: Aspergillus fumigatus / classification ,Microbiology (medical) ,medicine.medical_specialty ,Microbiology ,03 medical and health sciences ,MESH: Mycological Typing Techniques ,medicine ,MESH: Molecular Epidemiology ,Aspergillosis ,Humans ,Typing ,MESH: Cystic Fibrosis / complications ,Genotyping ,030304 developmental biology ,MESH: Humans ,030306 microbiology ,biology.organism_classification ,medicine.disease ,MESH: Cluster Analysis ,DNA Fingerprinting ,Immunology ,MESH: Aspergillus fumigatus / genetics ,MESH: Microsatellite Repeats ,MESH: Aspergillosis / microbiology ,Microsatellite Repeats - Abstract
International audience; A series of 256 Aspergillus fumigatus isolates, recovered from eight patients with cystic fibrosis (CF), were genotyped using microsatellite-based typing. Only a limited number of genotypes were shared between patients and co-colonisation with multiple strains was indicated for all patients. Additionally, some genotypes were isolated recurrently, indicating that they are capable of prolonged colonisation.
- Published
- 2008
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