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14 results on '"MESH: French Guiana/epidemiology"'

1. The singular epidemiology of HPV infection among French Guianese women with normal cytology

Author

Vincent Lacoste, Jean Luc Deshayes, Fatiha Najioullah, Hatem Ben Amor, Paul Brousse, Maylis Douine, Vincent Molinie, Raymond Césaire, Odile Kilié, Nadia Thomas, Valentin Dufit, Gabriel Carles, Remy Pignoux, Dominique Catherine, Antoine Adenis, Claire Grenier, Mathieu Nacher, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire de Virologie [Fort-de-France, Martinique], CHU de la Martinique [Fort de France], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Service de Gynecologie Obstétrique [Cayenne], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association de Dépistage Organisé des Cancers de Guyane (AGDOC), Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), The Study was funded by the European Regional Development Fund (FEDER) Presage number 30814., We wish to thank all study participants and the staff from the health centers of French Guiana., Lacoste, Vincent, Centre d'investigation clinique Antilles-Guyane ( CIC - Antilles Guyane ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU de la Martinique-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique], Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Association guyanaise de dépistage organisé des cancers ( AGDOC ), Service de gynécologie-obstétrique [Saint Laurent du Maroni, Guyane Française], Réseau International des Instituts Pasteur ( RIIP ), and Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine ( COREVIH Guyane )

Subjects
MESH: Cervix Uteri/cytology, MESH: Uterine Cervical Neoplasms/pathology, [SDV]Life Sciences [q-bio], MESH: Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms, Cervix Uteri, 0302 clinical medicine, Informed consent, Surveys and Questionnaires, Epidemiology, Prevalence, MESH: DNA, Viral/genetics, Medicine, 030212 general & internal medicine, Papillomaviridae, MESH: Aged, MESH: Papillomavirus Infections/epidemiology, Cervical cancer, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Middle Aged, Obstetrics, lcsh:Public aspects of medicine, HPV infection, virus diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Uterine Cervical Neoplasms/diagnosis, Middle Aged, female genital diseases and pregnancy complications, 3. Good health, French Guiana, [SDV] Life Sciences [q-bio], MESH: Papillomaviridae/genetics, Women's Health Services, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Papillomaviridae/isolation & purification, MESH: Young Adult, 030220 oncology & carcinogenesis, Female, Normal cytology, Research Article, Papanicolaou Test, Adult, medicine.medical_specialty, Human papillomavirus, MESH: French Guiana/epidemiology, Genotype, MESH: Papillomavirus Infections/prevention & control, MESH: Women's Health Services, MESH: Papanicolaou Test, Young Adult, 03 medical and health sciences, MESH: Cross-Sectional Studies, Humans, MESH: Papillomaviridae/classification, MESH: Surveys and Questionnaires, MESH: Uterine Cervical Neoplasms/prevention & control, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Prevalence, MESH: Papillomavirus Infections/pathology, Aged, Gynecology, MESH: Humans, business.industry, Public health, Papillomavirus Infections, Public Health, Environmental and Occupational Health, Cancer, MESH: Adult, lcsh:RA1-1270, medicine.disease, MESH: Papillomavirus Infections/diagnosis, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Concomitant, DNA, Viral, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Biostatistics, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; BACKGROUND:In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.METHODS:Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.RESULTS:Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.CONCLUSIONS:HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.

Published
2017

2. Dépistage du cancer du col de l'utérus en Guyane : taux de couverture du dépistage entre 2006 et 2011

Author

Maylis Douine, Christian Lelarge, Tristan Roue, Nadia Thomas, Mathieu Nacher, Antoine Adenis, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Registre des Cancers de Guyane, Laboratoire d’anatomopathologie - Abbeville, Laboratoire d’anatomopathologie, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Association Guyanaise Dépistage Organisé des Cancers [Cayenne] (A.G.D.O.C), and The present study was funded by the Health Regional Agency of French Guiana.

Subjects
Overseas department, MESH: Mass Screening/statistics & numerical data, MESH: Uterine Cervical Neoplasms/pathology, MESH: Mass Screening/organization & administration, MESH: Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms, 0302 clinical medicine, Epidemiology, Mass Screening, MESH: Incidence, Early Detection of Cancer, Cervical cancer, MESH: Middle Aged, 030219 obstetrics & reproductive medicine, Incidence, Incidence (epidemiology), Mortality rate, Age Factors, MESH: Uterine Cervical Neoplasms/diagnosis, Middle Aged, French Guiana, 3. Good health, 030220 oncology & carcinogenesis, Pap-smear, Screening, Female, Papanicolaou Test, Adult, medicine.medical_specialty, MESH: French Guiana/epidemiology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pathology and Forensic Medicine, 03 medical and health sciences, parasitic diseases, medicine, Humans, Neoplasm Invasiveness, MESH: Uterine Cervical Neoplasms/prevention & control, Mass screening, Retrospective Studies, MESH: Age Factors, Gynecology, MESH: Humans, MESH: Early Detection of Cancer*/statistics & numerical data, business.industry, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, MESH: Neoplasm Invasiveness, medicine.disease, Metropolitan France, MESH: Papanicolaou Test/statistics & numerical data, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract

International audience; In French Guiana, the age-standardized incidence rate of cervical cancer is four times higher than in France and the mortality rate 5.5 times higher. A survival study revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival. The present study aimed at evaluating the cervical cancer screening rate between 2006 and 2011 by age and for 3-years period in French Guiana. All pap smears realised in French Guiana were analysed in two laboratories allowing exhaustive review of screening data. The screening rate was estimated at about 54% from 2006 to 2011, with a statistical difference between coastal and rural area (56.3% versus 18.7%).Although the methodological difference did not allow comparisons with mainland France, these results could be used to evaluate the impact of organised cervical cancer screening by the French Guiana Association for Organized Screening of Cancers implemented in French Guiana since 2012.; En Guyane, l’incidence du cancer du col de l’utérus est quatre fois plus élevée qu’en métropole, et la létalité 5,5 fois plus élevée. Dans ce vaste département recouvert à plus de 90 % de forêt amazonienne, les difficultés d’accès aux soins, l’âge précoce au premier rapport et le manque de dépistage sont de possibles facteurs explicatifs. Une première étude a montré que le diagnostic tardif était le principal facteur impactant la survie. Un diagnostic précoce - par frottis cervico-vaginal tous les 3 ans de 25 à 64 ans selon les recommandations nationales - est donc crucial pour améliorer la survie. L’objectif de cette étude est d’évaluer le taux de couverture de dépistage par frottis en Guyane entre 2006 et 2011 ainsi que l’activité de réalisation de frottis et le taux de cancers dépistés. Tous les frottis cervico-vagin aux réalisés en Guyane sont analysés dans seulement deux laboratoires d’anatomie pathologique, ce qui permet une analyse exhaustive des données de dépistage de ce département. La date de naissance, la date de réalisation du frottis, l’adresse de la patiente ou celle du prescripteur (selon les laboratoires) ainsi que la date de réalisation du précédent frottis ont été recueillis. Le taux de couverture de dépistage a été évalué à 54 % entre 2006 et 2011, avec une différence significative entre le littoral et l’intérieur de la Guyane (56,3 % versus 18,7 %). L’activité de réalisation de frottis était de 23,5 à 25,8 frottis pour 100 femmes-année. Le taux de diagnostic de cancer était de 191,8/100 000 femmes année, soit un cancer cervical diagnostiqué pour 521 personnes dépistées. Bien que le taux de couverture de dépistage en Guyane ne semble pas très différent de la métropole, nous ne pouvons réaliser de comparaison statistique du fait de la différence de méthodologie utilisée. Le taux de diagnostic de cancer était de 6 à 12 fois plus élevé qu’en métropole, confirmant l’importance du dépistage par frottis en Guyane. Des efforts de dépistage doivent être réalisés notamment dans l’intérieur de la Guyane, où le taux de dépistage est plus faible. Cet état des lieux du dépistage entre 2006 et 2011 pourra permettre d’évaluer l’impact de la campagne organisée de dépistage du cancer du col mise en place en 2012 par l’Association guyanaise du dépistage organisé des cancers (AGDOC).

Published
2015

3. Is botulism type C transmissible to human by consumption of contaminated poultry meat? Analysis of a suspect outbreak in French Guyana

Author

Elodie Brulez, Cécile Stagnetto, Christiane Attica, Gérald Egmann, Michel-Robert Popoff, Arnaud Martrenchar, Jean-Michel Fontanella, Jérome Gruenfeld, Félix Djossou, Céline Dupuy, Direction des Services Vétérinaires [Gyuane], Direction départementale de la protection des populations [Guyane], direction générale des outre-mer (DGOM), Ministère des Outre-Mer (MOM), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence des Bactéries Anaérobies et Botulisme - National Reference Center Anaerobic Bacteria and Botulism (CNR), Institut Pasteur [Paris], Michel Bouisse (Direction of health and social development, 97300 Cayenne, French Guyana) and Jean-Philippe Carlier (National Reference Center for Anaerobic bacteria and Botulism, Institut Pasteur, Paris) were coauthors and deceased during the process of the manuscript. We thank B. Stiles for reviewing the manuscript., and Institut Pasteur [Paris] (IP)

Subjects
Veterinary medicine, MESH: Foodborne Diseases/diagnosis, [SDV]Life Sciences [q-bio], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], medicine.disease_cause, MESH: Clostridium botulinum type C/isolation & purification, Poultry, Disease Outbreaks, Foodborne Diseases, MESH: Poultry, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], MESH: Botulism/pathology, Medicine, MESH: Animals, Botulism, 0303 health sciences, Transmission (medicine), Botulinum toxin, French Guiana, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, Botulinum neurotoxin, MESH: Botulism/transmission, medicine.drug, MESH: French Guiana/epidemiology, MESH: Disease Transmission, Infectious, Clostridium botulinum type C, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Microbiology, 03 medical and health sciences, Disease Transmission, Infectious, Animals, Humans, 030304 developmental biology, MESH: Disease Outbreaks, MESH: Humans, 030306 microbiology, business.industry, MESH: Botulism/diagnosis, MESH: Foodborne Diseases/pathology, Outbreak, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Poultry meat, Clostridium botulinum, Flock, business
Abstract

International audience; Botulism type C was suspected in a 46-year old man after consumption of sick poultry from a flock where botulism type C was confirmed. The patient developed characteristic signs of botulism, but investigation of biological samples did not confirm the presence of Clostridium botulinum or botulinum toxin. Despite having classical botulism symptoms, the man recovered very quickly. This raises the question of botulism transmission to humans by ingestion of contaminated poultry.

Published
2019

4. Mycobacterium ulcerans infection (Buruli ulcer) in French Guiana, South America, 1969–2013: an epidemiological study

Author

Sylvain Labbé, Dominique Sainte-Marie, Roger Pradinaud, Rodolphe E. Gozlan, Mathieu Nacher, Jean-François Guégan, Maylis Douine, J. Dufour, Pierre Couppié, Yann Reynaud, Christine Chevillon, Alain Berlioz-Arthaud, Marine Combe, Eric Elguero, Camilla Jensen Velvin, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne] (COREVIH), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Evolution of host-microbe communities (MIVEGEC-EVCO), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Pasteur de la Guyane, Service de Dermatologie [Cayenne, Guyanne Française], Centre Hospitalier Andre Rosemon, This work was funded by an 'Investissement d’Avenir' grant managed by Agence Nationale de la Recherche (Centre d’Étude de la Biodiversité Amazonienne, reference ANR-10-LABX-2501)., Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Génétique et évolution des maladies infectieuses (GEMI), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Génétique et évolution des maladies infectieuses (GEMI)

Subjects
Male, Buruli ulcer, Health (social science), Medicine (miscellaneous), MESH: Mycobacterium ulcerans, MESH: Buruli Ulcer/epidemiology, 0302 clinical medicine, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, Epidemiology, 030212 general & internal medicine, MESH: Incidence, Child, Buruli Ulcer, lcsh:Environmental sciences, lcsh:GE1-350, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, biology, Transmission (medicine), Incidence, Health Policy, Incidence (epidemiology), MESH: Infant, Newborn, Middle Aged, MESH: Infant, French Guiana, 3. Good health, MESH: Young Adult, Child, Preschool, Mycobacterium ulcerans, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Leprosy, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, MESH: French Guiana/epidemiology, 030231 tropical medicine, Bone Infection, Young Adult, 03 medical and health sciences, medicine, Humans, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, MESH: Adult, medicine.disease, biology.organism_classification, Dermatology, MESH: Male, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract

Summary Background Mycobacterium ulcerans infection is the third most common mycobacterial disease in the world after tuberculosis and leprosy. To date, transmission pathways from its environmental reservoir to humans are still unknown. In South America, French Guiana has the highest reported number of M ulcerans infections across the continent. This empirical study aimed to characterise the epidemiology of M ulcerans infection in French Guiana between 1969 and 2013. Methods Data were collected prospectively mainly by two dermatologists at Cayenne Hospital's dermatology department between Jan 1, 1969, and Dec 31, 2013, for age, date of diagnosis, sex, residence, location of the lesion, type of lesion, associated symptoms, and diagnostic method (smear, culture, PCR, or histology) for all confirmed and suspected cases of M ulcerans . We obtained population data from censuses. We calculated mean M ulcerans infection incidences, presented as the number of cases per 100 000 person-years. Findings 245 patients with M ulcerans infections were reported at Cayenne Hospital's dermatology department during the study period. M ulcerans infection incidence decreased over time, from 6·07 infections per 100 000 person-years (95% CI 4·46–7·67) in 1969–83 to 4·77 infections per 100 000 person-years (3·75–5·79) in 1984–98 and to 3·49 infections per 100 000 person-years (2·83–4·16) in 1999–2013. The proportion of children with infections also declined with time, from 42 (76%) of 55 patients in 1969–83 to 26 (31%) of 84 in 1984–98 and to 22 (21%) of 106 in 1999–2013. Most cases occurred in coastal areas surrounded by marshy savannah (incidence of 21·08 per 100 000 person-years in Sinnamary and 21·18 per 100 000 person-years in Mana). Lesions mainly affected limbs (lower limbs 161 [66%] patients; upper limbs 60 [24%] patients). We diagnosed no bone infections. Interpretation The decrease of M ulcerans infection incidence and the proportion of children with infections over a 45 year period in this ultra-peripheral French territory might have been mostly driven by improving living conditions, prophylactic recommendations, and access to health care. Funding Agence Nationale de la Recherche.

Published
2017

5. High prevalence of HPV infection in the remote villages of French Guiana: an epidemiological study

Author

Florine Corlin, Vincent Lacoste, Mathieu Nacher, Vincent Molinie, Raymond Césaire, Valentin Dufit, Antoine Adenis, Maylis Douine, Gabriel Carles, Fatiha Najioullah, Gulen Ayhan, Paul Brousse, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, European Regional Development Fund - FEDER presage n°30814 - INCOMING, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique] (EA 4537), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de gynécologie-obstétrique [Saint Laurent du Maroni, Guyane Française], Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This project was supported by an European Union Grant (PO FEDER 2007-2013, No. Présage: 30814, Guyane Française., We thank the health professionals of the Centres Délocalisés de Prévention et de Soins and the Protection Maternelle et Infantile., European Project: FEDER presage n°30814, and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)

Subjects
Genotyping Techniques, Epidemiology, Prevalence, MESH: Genotype, 0302 clinical medicine, 5. Gender equality, MESH: Papillomavirus Infections/virology, MESH: DNA, Viral/genetics, 030212 general & internal medicine, MESH: Cytological Techniques, Papillomaviridae, Cervical cancer, MESH: Aged, MESH: Papillomavirus Infections/epidemiology, education.field_of_study, MESH: Middle Aged, MESH: Epidemiologic Studies, Incidence (epidemiology), HPV infection, Middle Aged, Original Papers, 3. Good health, French Guiana, Vaccination, MESH: Papillomaviridae/genetics, Infectious Diseases, MESH: Papillomaviridae/isolation & purification, MESH: Young Adult, 030220 oncology & carcinogenesis, Female, MESH: DNA, Viral/analysis, Adult, medicine.medical_specialty, HPV, MESH: Vaginal Smears, MESH: French Guiana/epidemiology, Genotype, Population, Cytological Techniques, 03 medical and health sciences, Young Adult, MESH: Genotyping Techniques, medicine, Humans, MESH: Papillomaviridae/classification, education, MESH: Prevalence, Aged, Gynecology, Vaginal Smears, MESH: Humans, business.industry, Public health, Papillomavirus Infections, MESH: Adult, medicine.disease, Epidemiologic Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, DNA, Viral, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract

SUMMARYCervical cancer is the second most frequent cancer in women in French Guiana. Studies have shown that populations living in the remote areas of the interior have early sexual debut and that multiple sexual partnerships are common. The objective of the present study was thus to determine the prevalence of human papillomavirus (HPV) infection in these areas. A study was conducted in women aged 20–65 years with previous sexual activity. Women were included on a voluntary basis after using local media and leaders to inform them of the visit of the team. HPV infection was defined by the detection of HPV DNA using the Greiner Bio-One kit. In addition to HPV testing cytology was performed. The overall age-standardized prevalence rate was 35%. There was a U-shaped evolution of HPV prevalence by age with women aged >50 years at highest risk for HPV, followed by the 20–29 years group. Twenty-seven percent of women with a positive HPV test had normal cytology. Given the high incidence of cervical cancer in French Guiana and the high prevalence of HPV infections the present results re-emphasize the need for screening for cervical cancer in these remote areas. Vaccination against HPV, preferably with a nonavalent vaccine, also seems an important prevention measure. However, in this region where a large portion of the population has no health insurance, this still represents a challenge.

Published
2017

6. Patawa Virus, a New Arenavirus Hosted by Forest Rodents in French Guiana

Author

Séverine Matheus, Anne Lavergne, François Catzeflis, Damien Donato, Benoit de Thoisy, Amandine Guidez, Vincent Lacoste, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Association Kwata - Etude et protection de la nature [Guyane], Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), This study was conducted within the ViRUSES program, supported by European funds (FEDER) and assistance from Région Guyane and Direction Régionale pour la Recherche et la Technologie, and received a European commission 'REGPOT-CT-2011-285837-STRonGer' Grant within the FP7 and an 'Investissement d’Avenir' Grant managed by Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABX-25-01). Field work at Cacao was funded by Agence Nationale de la Recherche under contract 2006-SEST-20-01 attributed to Th. De Meeus., FC acknowledges the technical expertise of Michel Gillioz at the Geneva Natural History Museum for curating specimens with care., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-06-NEUR-0039,OlfLocalTrans,Traduction locale axonale et dendritique dans le développement et le renouvellement du système olfactif(2006), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)

Subjects
Rodent Diseases, MESH: French Guiana/epidemiology, Rodent, viruses, Health, Toxicology and Mutagenesis, MESH: Arenaviridae Infections/epidemiology, Forests, MESH: Base Sequence, phylogeny, MESH: Rodent Diseases/epidemiology, Amazonia, biology.animal, Animals, Arenaviridae Infections, MESH: Animals, Sigmodontinae, MESH: Sigmodontinae/virology, arenavirus, MESH: Rodent Diseases/virology, Muridae, Arenavirus, Base Sequence, Oecomys, Ecology, biology, Amazon rainforest, MESH: Arenavirus/isolation & purification, rodent, MESH: Forests, biology.organism_classification, French Guiana, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Animal ecology, MESH: Arenaviridae Infections/veterinary
Abstract

International audience; Molecular screening of rodents from French Guiana has detected a new arenavirus, named ''Pata-wa,'' in two Oecomys species (Muridae, Sigmodontinae). Further investigations are needed to better understand the circulation of this virus in rodent and human populations and its public health impact.

Published
2014

7. HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012

Author

Anne Lavergne, Leila Adriouch, Félix Djossou, Myriam El Guedj, Mathieu Nacher, Vincent Lacoste, Alain Berlioz-Arthaud, Edith Darcissac, Pierre Couppié, Rachida Boukhari, Edouard Tanguy, Emmanuelle Papot, Vincent Vantilcke, Damien Donato, Jean-François Pouliquen, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni), Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française], This work was funded by the Institut Pasteur de la Guyane. It has also benefited from a European commission REGPOT-CT-2011-285837-STRonGer grant within the FP7, The authors thank Nathalie Jolly from the Institut Pasteur Clinical Research Department (PIRC, Pôle Intégré de Recherche Clinique) for her help in the ethical aspects of the project. They also thank Ketty Bienvenu, Lidia Saint Louis, Sergine Soyon, and Karine Verin for their invaluable assistance., European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), Lacoste, Vincent, Strengthening transdisciplinary research on infectious and emerging diseases in French Guiana: linking fieldwork, benchside and bedside - STRONGER - - EC:FP7:REGPOT2011-11-01 - 2015-04-30 - 285837 - VALID, and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)

Subjects
0301 basic medicine, Male, [SDV]Life Sciences [q-bio], HIV Infections, Drug resistance, MESH: Genotype, 0302 clinical medicine, MESH: HIV Protease/genetics, HIV Protease, MESH: HIV-1/growth & development, Polymorphism (computer science), Genotype, 030212 general & internal medicine, Genetics, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Aged, MESH: HIV Infections/epidemiology, Molecular Epidemiology, MESH: Middle Aged, Incidence (epidemiology), MESH: HIV Infections/drug therapy, Middle Aged, Viral Load, MESH: HIV Infections/virology, MESH: HIV-1/genetics, HIV Reverse Transcriptase, 3. Good health, French Guiana, [SDV] Life Sciences [q-bio], MESH: HIV Protease Inhibitors/therapeutic use, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Reverse Transcriptase Inhibitors, Female, Viral load, Adult, MESH: French Guiana/epidemiology, Immunology, Biology, MESH: Reverse Transcriptase Inhibitors/therapeutic use, MESH: Drug Resistance, Viral/genetics, 03 medical and health sciences, MESH: Polymorphism, Genetic, MESH: Viral Load/drug effects, Acquired immunodeficiency syndrome (AIDS), Virology, Drug Resistance, Viral, medicine, Humans, MESH: Molecular Epidemiology, MESH: HIV Reverse Transcriptase/genetics, Aged, Retrospective Studies, Genetic diversity, Polymorphism, Genetic, MESH: Humans, Molecular epidemiology, MESH: Adult, MESH: Retrospective Studies, HIV Protease Inhibitors, medicine.disease, MESH: Male, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Mutation, HIV-1, MESH: Mutation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, MESH: HIV-1/drug effects
Abstract

International audience; Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.

Published
2016

8. Prospective Zika virus disease cohort: systematic screening

Author

Marianne Maquart, Séverine Matheus, Franck de Laval, Nicolas Barthes, Cédric Combes, Emmanuel Yvrard, Isabelle Leparc-Goffart, Sébastien Briolant, Dominique Rousset, Direction Interarmées du Service de Santé en Guyane, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI), Université de La Réunion (UR), Centre National de Référence (CNR) des Arbovirus - Laboratoire coordonnateur : Equipe Résidente de Recherche d'Infectiologie Tropicale (ERRIT), Institut de Recherche Biomédicale des Armées Hôpital d’Instruction des Armées Laveran, Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Service de Santé des Armées, Institut pluridisciplinaire de recherche appliquée dans le domaine du génie pétrolier (IPRADDGP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Unité de Virologie, Institut de Médecine Tropicale du Service de Santé des Armées, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), Entomologie médicale, Laboratoire de Parasitologie [Cayenne, Guyane française], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur de la Guyane, Hôpital d'Instruction des Armées Laveran, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Zika virus disease, Male, Medical entomology, MESH: Travel, Zika virus, MESH: Zika Virus Infection/epidemiology, Health services, 0302 clinical medicine, MESH: Suriname, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Mass Screening, 030212 general & internal medicine, Prospective Studies, MESH: Zika Virus Infection/diagnosis, ComputingMilieux_MISCELLANEOUS, Fatigue, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Travel, MESH: Zika Virus Infection/complications, Suriname, biology, Zika Virus Infection, Headache, General Medicine, MESH: Arthralgia/virology, 16. Peace & justice, Arthralgia, 3. Good health, French Guiana, Geography, MESH: Pruritus/virology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, MESH: Headache/virology, medicine.medical_specialty, MESH: Mass Screening, MESH: French Guiana/epidemiology, Fever, MESH: Fever/virology, 030231 tropical medicine, Library science, MESH: Zika Virus/isolation & purification, 03 medical and health sciences, MESH: Infection Control*/methods, MESH: Zika Virus Infection/transmission, medicine, Humans, MESH: Conjunctivitis/virology, MESH: Myalgia/virology, MESH: Exanthema/virology, Mass screening, Infection Control, MESH: Humans, MESH: Zika Virus/genetics, Public health, Pruritus, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Myalgia, Zika Virus, Exanthema, medicine.disease, biology.organism_classification, Conjunctivitis, MESH: Male, MESH: Prospective Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Fatigue/virology, MESH: Female
Abstract

Military Centre for Epidemiology and Public Health, Camp Militaire de Sainte Marthe, Marseille, France (FdL); French Armed Forces Health Service in French Guiana, Quartier La Madeleine, BP 6019, 97306 Cayenne Cedex, French Guiana (FdL, NB, CC, SB); Institut Pasteur of French Guiana, Laboratory of Virology, National Reference Centre for Arboviruses (SM, DR), and Unit of Medical Entomology (SB), Cayenne, French Guiana; French Armed Forces Biomedical Research Institute, National Reference Centre for Arboviruses (MM, EY, IL-G), and Unit of Parasitology and Medical Entomology (SB), Hopital d’Instruction des Armees Laveran, Marseille, France; Research Unit in Emerging Infectious and Tropical Diseases, UM 63, CNRS 7278, IRD 198, and INSERM 1095, Faculte de Medecine La Timone, Aix-Marseille Universite, Marseille, France (SB)

Published
2016

9. Predictive factors of the survival of women with invasive breast cancer in French Guiana: the burden of health inequalities

Author

Sophie Belliardo, Maylis Douine, Tristan Roue, Sylvain Labbé, Mathieu Nacher, Juliette Plenet, Registre des Cancers de Guyane, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), The present study was funded by the Health Regional Agency of French Guiana., The authors thank Professor J.P. Droz for a critical reading of the manuscript., Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and ADENIS, ANTOINE

Subjects
Cancer Research, Pediatrics, Survival, Immigration, Health Services Accessibility, MESH: Healthcare Disparities/statistics & numerical data, 0302 clinical medicine, Breast cancer, MESH: Aged, 80 and over, Risk Factors, MESH: Risk Factors, Medicine, 030212 general & internal medicine, Early Detection of Cancer, MESH: Breast Neoplasms/pathology, media_common, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Relative survival, Carcinoma, Ductal, Breast, Age Factors, MESH: Neoplasm Staging, Place of birth, Middle Aged, Prognosis, MESH: Emigrants and Immigrants, 3. Good health, French Guiana, Survival Rate, Oncology, MESH: Breast Neoplasms/mortality, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, Immigrant, Adult, medicine.medical_specialty, MESH: Socioeconomic Factors, MESH: Early Detection of Cancer/statistics & numerical data, MESH: French Guiana/epidemiology, MESH: Survival Rate, media_common.quotation_subject, Emigrants and Immigrants, Breast Neoplasms, MESH: Carcinoma, Ductal, Breast/mortality, MESH: Prognosis, 03 medical and health sciences, South America Word count : 2278, MESH: Health Services Accessibility, parasitic diseases, Humans, Healthcare Disparities, Survival rate, Survival analysis, Aged, Neoplasm Staging, MESH: Age Factors, MESH: Humans, business.industry, MESH: Adult, medicine.disease, Survival Analysis, MESH: Carcinoma, Ductal, Breast/pathology, Cancer registry, Metropolitan France, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract

International audience; This study aimed to compare the relative survival of patients with invasive breast cancer between women from French Guiana (a French territory in South America) and metropolitan France. No study hadever compared survival of breast cancer on the basis of immigrant status in France. Our study underlined that access to care for migrants is challenging whichwgenerates health inequalities. Background The prognosis of breast cancer in French Guiana is worse than in France with 23 deaths per 100 incident cases against 17 per 100 in metropolitan France. This study aimed to compare relative survival of patients with invasive breast cancer (IBC) between women from French Guiana and metropolitan France and to determine risk factors influencing breast cancer survival in French Guiana.Materials and methods Data were collected from the Cancer registry of French Guiana. We comparedthe relative survival of women with IBC between French Guiana and metropolitan France. We used Cox's proportional hazard regression to evaluate the effect of prognostic factors on cancer-specific mortality in French Guiana. Results We included all 269 cases of IBC in women diagnosed in French Guiana between 2003 and 2009. The overall 5-year relative survival rate of patients with IBC was 79% in French Guiana and 86% in metropolitan France. The place of birth (foreign country versus French territory), the tumor stage at the time of diagnosis, the mode of diagnosis (symptoms versus screening), the presence of hormone receptors in the tumor and the histologic type were the variables associated with survival differences. None of the other study variables were significantly associated with prognosis. Conclusion Access to care for migrants is challenging,which leads to health inequalities. Early detection through prevention programs is crucial to increaseIBC survival notably for foreign-born patients.

Published
2016

10. Screening for cervical cancer in French Guiana: screening rates from 2006 to 2011

Author

Douine, Maylis, Roue, Tristan, Lelarge, Christian, Adenis, Antoine, Thomas, Nadia, Nacher, Mathieu, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Registre des Cancers de Guyane, Laboratoire d’anatomopathologie - Abbeville, Laboratoire d’anatomopathologie, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Association Guyanaise Dépistage Organisé des Cancers [Cayenne] (A.G.D.O.C), and The present study was funded by the Health Regional Agency of French Guiana.

Subjects
MESH: Age Factors, MESH: Humans, MESH: Middle Aged, MESH: Early Detection of Cancer*/statistics & numerical data, MESH: French Guiana/epidemiology, MESH: Mass Screening/statistics & numerical data, MESH: Uterine Cervical Neoplasms/pathology, Overseas department, MESH: Mass Screening/organization & administration, MESH: Uterine Cervical Neoplasms/epidemiology, MESH: Adult, MESH: Retrospective Studies, MESH: Uterine Cervical Neoplasms/diagnosis, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Neoplasm Invasiveness, French Guiana, Pap-smear, Cervical cancer, Screening, MESH: Papanicolaou Test/statistics & numerical data, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Incidence, MESH: Uterine Cervical Neoplasms/prevention & control, MESH: Female
Abstract

International audience; In French Guiana, the age-standardized incidence rate of cervical cancer is four times higher than in France and the mortality rate 5.5 times higher. A survival study revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival. The present study aimed at evaluating the cervical cancer screening rate between 2006 and 2011 by age and for 3-years period in French Guiana. All pap smears realised in French Guiana were analysed in two laboratories allowing exhaustive review of screening data. The screening rate was estimated at about 54% from 2006 to 2011, with a statistical difference between coastal and rural area (56.3% versus 18.7%).Although the methodological difference did not allow comparisons with mainland France, these results could be used to evaluate the impact of organised cervical cancer screening by the French Guiana Association for Organized Screening of Cancers implemented in French Guiana since 2012.; En Guyane, l’incidence du cancer du col de l’utérus est quatre fois plus élevée qu’en métropole, et la létalité 5,5 fois plus élevée. Dans ce vaste département recouvert à plus de 90 % de forêt amazonienne, les difficultés d’accès aux soins, l’âge précoce au premier rapport et le manque de dépistage sont de possibles facteurs explicatifs. Une première étude a montré que le diagnostic tardif était le principal facteur impactant la survie. Un diagnostic précoce - par frottis cervico-vaginal tous les 3 ans de 25 à 64 ans selon les recommandations nationales - est donc crucial pour améliorer la survie. L’objectif de cette étude est d’évaluer le taux de couverture de dépistage par frottis en Guyane entre 2006 et 2011 ainsi que l’activité de réalisation de frottis et le taux de cancers dépistés. Tous les frottis cervico-vagin aux réalisés en Guyane sont analysés dans seulement deux laboratoires d’anatomie pathologique, ce qui permet une analyse exhaustive des données de dépistage de ce département. La date de naissance, la date de réalisation du frottis, l’adresse de la patiente ou celle du prescripteur (selon les laboratoires) ainsi que la date de réalisation du précédent frottis ont été recueillis. Le taux de couverture de dépistage a été évalué à 54 % entre 2006 et 2011, avec une différence significative entre le littoral et l’intérieur de la Guyane (56,3 % versus 18,7 %). L’activité de réalisation de frottis était de 23,5 à 25,8 frottis pour 100 femmes-année. Le taux de diagnostic de cancer était de 191,8/100 000 femmes année, soit un cancer cervical diagnostiqué pour 521 personnes dépistées. Bien que le taux de couverture de dépistage en Guyane ne semble pas très différent de la métropole, nous ne pouvons réaliser de comparaison statistique du fait de la différence de méthodologie utilisée. Le taux de diagnostic de cancer était de 6 à 12 fois plus élevé qu’en métropole, confirmant l’importance du dépistage par frottis en Guyane. Des efforts de dépistage doivent être réalisés notamment dans l’intérieur de la Guyane, où le taux de dépistage est plus faible. Cet état des lieux du dépistage entre 2006 et 2011 pourra permettre d’évaluer l’impact de la campagne organisée de dépistage du cancer du col mise en place en 2012 par l’Association guyanaise du dépistage organisé des cancers (AGDOC).

Published
2015

11. Short Report : Maripa hantavirus in French Guiana : phylogenetic position and predicted spatial distribution of rodent hosts

Author

de Thoisy, Benoît, Matheus, Séverine, Catzeflis, François, Clément, Luc, Barrioz, Sébastien, Guidez, Amandine, Donato, Damien, Cornu, Jean-François, Brunaux, Olivier, Guitet, Stéphane, Lacoste, Vincent, Lavergne, Anne, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Laboratoire de Paléontologie-Paléobiologie-Phylogénie (UMR CNRS 5554), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Association Kwata - Etude et protection de la nature [Guyane], Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), ONF - Direction régionale de la Guyane [Cayenne], Office national des forêts (ONF), This study was supported by Fonds Européen de Développement Régional (FEDER) and assistance from Région Guyane and Direction Régionale pour la Recherche et la Technologie. This study benefited from European Commission Grant REGPOT-CT-2011-285837-STRonGer in the frame of FP7 and an Investissement d’Avenir Grant managed by Agence Nationale de la Recherche (Centre d’Etude de la Biodiversité Amazonienne [CEBA], ANR-10-LABX-25-01)., This study was conducted within the Virus-Reservoirs-Urbanisation-Surveillance de l#x0027, Emergence en Amérique du Sud (ViRUSES) program. F.C. acknowledges the technical expertise of Michel Gillioz at the Natural History Museum of Geneva, who curated our specimens with care., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), European Project: ERDF/FEDER,ViRUSES, Université Montpellier 2 - Sciences et Techniques (UM2), and Office National des Forêts (ONF)

Subjects
MESH: Rodent Diseases/epidemiology, MESH: Disease Reservoirs, MESH: Sequence Analysis, DNA, MESH: DNA, Complementary/genetics, MESH: Humans, MESH: Molecular Sequence Data, MESH: French Guiana/epidemiology, MESH: Kidney/virology, MESH: Rodent Diseases/virology, MESH: Rodentia, MESH: animals, MESH: Demography, MESH: Lung/virology, MESH: DNA, Complementary/chemistry, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: hantavirus, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: RNA, Viral/genetics, MESH: Phylogeny
Abstract

International audience; A molecular screening of wild-caught rodents was conducted in French Guiana, South America to identify hosts of the hantavirus Maripa described in 2008 in a hantavirus pulmonary syndrome (HPS) case. Over a 9-year period, 418 echimyids and murids were captured. Viral RNA was detected in two sigmodontine rodents, Oligoryzomys fulvescens and Zygodontomys brevicauda, trapped close to the house of a second HPS case that occurred in 2009 and an O. fulvescens close to the fourth HPS case identified in 2013. Sequences from the rodents had 96% and 97% nucleotide identity (fragment of S and M segments, respectively) with the sequence of the first human HPS case. Phylogenetic reconstruc-tions based on the complete sequence of the S segment show that Maripa virus is closely related to Rio Mamore hantavirus. Using environmental descriptors of trapping sites, including vegetation, landscape units, rain, and human disturbance, a maximal entropy-based species distribution model allowed for identification of areas of higher predicted occurrence of the two rodents, where emergence risks of Maripa virus are expected to be higher. Hantaviruses (Bunyaviridae) are distributed worldwide.

Published
2014

12. Salmonella serotypes in reptiles and humans, French Guiana

Author

Noellie Gay, Simon Le Hello, François-Xavier Weill, Benoit de Thoisy, Franck Berger, Unité d'Epidémiologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence des Salmonella - Bactéries pathogènes entériques (CNR), Institut Pasteur [Paris], Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella (CNR-ESS), Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], This study was supported by Institut Pasteur and Institut Pasteur de la Guyane and benefited from an ‘‘Investissementd’Avenir’’ grant managed by Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), and Institut Pasteur [Paris] (IP)

Subjects
Serotype, Veterinary medicine, Salmonella, MESH: Reptiles/microbiology, medicine.disease_cause, L73 - Maladies des animaux, Génétique des populations, MESH: Animals, Cloacal swab, Zoonosis, Consommation alimentaire, General Medicine, MESH: Salmonella Infections/epidemiology, MESH: Salmonella Infections/transmission, 3. Good health, French Guiana, South american, S50 - Santé humaine, Salmonella Infections, MESH: Salmonella/classification, Q03 - Contamination et toxicologie alimentaires, Genre humain, zoonose, MESH: French Guiana/epidemiology, Viande, Reptile, Biology, Microbiology, MESH: Salmonella/genetics, medicine, Animals, Humans, Serotyping, Transmission des maladies, Disease Reservoirs, MESH: Salmonella Infections/microbiology, MESH: Humans, General Veterinary, MESH: Salmonella/isolation & purification, MESH: Serotyping, Reptiles, medicine.disease, Sérotype, Metropolitan France, Carriage, MESH: Disease Reservoirs/microbiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; In French Guiana, a French overseas territory located in the South American northern coast, nearly 50% of Salmonella serotypes isolated from human infections belong to serotypes rarely encountered in metropolitan France. A reptilian source of contamination has been investigated. Between April and June 2011, in the area around Cayenne, 151 reptiles were collected: 38 lizards, 37 snakes, 32 turtles, 23 green iguanas and 21 caimans. Cloacal swab samples were collected and cultured. Isolated Salmonella strains were identified biochemically and serotyped. The overall carriage frequency of carriage was 23.2% (95% confidence interval: 16.7-30.4) with 23 serotyped strains. The frequency of Salmonella carriage was significantly higher for wild reptiles. Near two-thirds of the Salmonella serotypes isolated from reptiles were also isolated from patients in French Guiana. Our results highlight the risk associated with the handling and consumption of reptiles and their role in the spread of Salmonella in the environment.

Published
2013

13. Hospitalized cases of influenza A(H1N1)pdm09 in the French territories of the Americas, July 2009-March 2010

Author

Séverine Matheus, Sylvie Cassadou, Marie Barrau, J. Renner, J. L. Chappert, Coralie Gasc, Philippe Quénel, Fatiha Najioullah, Sophie Larrieu, Philippe Dussart, Martine Ledrans, Cellule de l'Institut de Veille Sanitaire en régions Antilles Guyane, Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Service de virologie-immunologie, Centre hospitalier Universitaire, Réseau International des Instituts Pasteur (RIIP), and The authors are grateful to all of the sentinel network practitioners, the clinicians, the Centre National de Référence des Arbovirus (Guyane, France), and the Service de virologie-immunologie of the Centre Hospitalier Universitaire (Martinique, France) for their participation in providing clinical data for this surveillance system. We also thank Vanessa Ardillon, Alain Blateau, Claude Flamand, and Jacques Rosine, epidemiologists at CIRE (Antilles Guyane), for their contribution to the surveillance system.

Subjects
Male, epidemiologic methods, MESH: Comorbidity, Comorbidity, medicine.disease_cause, MESH: Influenza, Human/epidemiology, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, MESH: Pregnancy, MESH: Aged, 80 and over, Pregnancy, MESH: Child, Pandemic, virus diseases, Influenza A virus, 030212 general & internal medicine, Hospital Mortality, Pregnancy Complications, Infectious, Child, Guadeloupe, MESH: Guadeloupe/epidemiology, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, MESH: Pneumonia, Viral/epidemiology, epidemiological surveillance, MESH: Infant, Newborn, Middle Aged, MESH: Infant, 3. Good health, French Guiana, Hospitalization, MESH: Young Adult, Child, Preschool, Population Surveillance, MESH: Influenza, Human/virology, Female, Martinique, Adult, medicine.medical_specialty, Adolescent, MESH: French Guiana/epidemiology, Multiple Organ Failure, West Indies, 030231 tropical medicine, Pneumonia, Viral, sentinel surveillance, MESH: Multiple Organ Failure/epidemiology, MESH: Martinique/epidemiology, MESH: Population Surveillance, 03 medical and health sciences, Young Adult, MESH: Multiple Organ Failure/virology, Internal medicine, Diabetes mellitus, Intensive care, Influenza, Human, medicine, MESH: Influenza A Virus, H1N1 Subtype, MESH: Pregnancy Complications, Infectious/epidemiology, Humans, MESH: Pneumonia, Viral/virology, MESH: Hospital Mortality, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Public Health, Environmental and Occupational Health, Infant, Newborn, Outbreak, Infant, Influenza a, MESH: Adult, medicine.disease, MESH: Male, Surgery, H1N1 subtype, Observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: West Indies/epidemiology, MESH: Female, MESH: Hospitalization/statistics & numerical data
Abstract

International audience; OBJECTIVE: To describe the methodology used for implementing a surveillance system specifically for influenza A(H1N1)pdm09 in the French West Indies and French Guiana during an outbreak of this new virus in 2009-2010, and to report its main results. METHODS: This was an observational descriptive study of confirmed and probable cases of influenza A(H1N1)pdm09 hospitalized for at least 24 hours in 23 July 2009-3 March 2010. Reverse transcription polymerase chain reaction was performed on nasopharyngeal swab samples according to the Centers for Disease Control and Prevention protocol. A probable case was defined as fever > 38ºC or aches or asthenia with respiratory symptoms (cough or dyspnea). All confirmed and probable hospitalized cases were reported, along with patient's age, sex, clinical condition at admission, place and length of hospitalization, antiviral treatment, underlying conditions, complications, and clinical evolution. A case was classified as severe if respiratory assistance or intensive care was required or if death resulted. RESULTS: A total of 331 confirmed and 16 probable cases were hospitalized, with a hospitalization rate ranging from 4.3 per 1 000 clinical cases in Saint Martin to 10.3 in French Guiana. Of these, 36 were severe, and subsequently, 10 were fatal. The median length of stay was 4 days for non-severe cases and 9 days for severe (P < 0.05). The mean patient age was 21 years, and severe cases were significantly older than non-severe (mean: 38 years versus 19 years, P < 0.05). Underlying conditions associated with a higher risk of severity were 65 years of age or more (RR = 7.5, 95%CI = 4.2-13.3), diabetes (RR = 3.7, 95%CI = 1.5-9.4), cardiac insufficiency (RR = 8.4, 95%CI = 5.2-13.6), and morbid obesity (RR = 4.4, 95%CI = 1.8-10.4). Patients who received antiviral treatment within 2 days of symptom onset had shorter hospital stays (mean: 4 days versus 6.5 days, P < 0.05), and the illness tended to become less severe (11.1% versus 19.0%, P = 0.13). CONCLUSIONS: Active research of hospitalized cases enabled almost exhaustive surveillance. The pandemic's hospitalization rates and lethality were more moderate than expected. Some previously known underlying conditions of severity were confirmed during this outbreak. Furthermore, these results show the validity of early antiviral treatment.

Published
2012

14. Outbreaks of Disease Possibly Due to a Natural Avian Herpesvirus Infection in a Colony of Young Magnificent Frigatebirds (Fregata magnificens) in French Guiana

Author

Anne Lavergne, Julien Semelin, Vincent Lacoste, Benoit de Thoisy, Fabian Blanchard, Jean-François Pouliquen, Eric Hansen, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Association Kwata - Etude et protection de la nature [Guyane], Réserve Naturelle Nationale de l’Ile du Grand-Connétable [Guyane], Réserves Naturelles de France, Unité Biodiversité Halieutique de Guyane [Cayenne] (BIODIVHAL), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Office National de la Chasse et de la Faune Sauvage [Kourou, Guyane], Institut National de la Recherche Agronomique (INRA)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-AgroParisTech-Université des Antilles (Pôle Guadeloupe), Université des Antilles (UA)-Université des Antilles (UA), Investigations were funded by the Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane, by the French Guiana’s Regional Environmental Authority (DIREN), and by the French Space Agency (CNES) under a State-Region Planning Contract/Single Programming Document (CPER/DocUP)., We are grateful to French Guiana’s Department of Veterinary Services, H. Morvan (Veterinary Research Laboratory on Poultry and Swine, Ploufragan, France), O. Chastel (Chizé Center for Biological Studies, CNRS, France), J. M. Pericard (Association of Avian Veterinarians), and M. L’Hostis (National Veterinary School, Nantes, France) for discussions on the clinical cases and diagnosis., Université des Antilles (Pôle Guadeloupe), Université des Antilles (UA)-Université des Antilles (UA)-Institut National de la Recherche Agronomique (INRA)-Université de Guyane (UG)-Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-AgroParisTech, Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Institut Pasteur de la Guyane, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (Pôle Guadeloupe)

Subjects
Pelecaniformes, Male, MESH: Bird Diseases/mortality, MESH: Herpesviridae Infections/veterinary, Alphaherpesvirinae, Disease Outbreaks, 0403 veterinary science, MESH: Disease Outbreaks/veterinary, MESH: Animals, Alphaherpesvirus, MESH: Herpesviridae Infections/pathology, Nature reserve, Bird Diseases, 0303 health sciences, education.field_of_study, Ecology, 04 agricultural and veterinary sciences, Herpesviridae Infections, MESH: Nutritional Status, French Guiana, Beak, MESH: Birds, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Conservation of Natural Resources, Female, Conservation of Natural Resources, MESH: French Guiana/epidemiology, MESH: Herpesviridae Infections/mortality, 040301 veterinary sciences, Population, Nutritional Status, Biology, Birds, 03 medical and health sciences, Frigatebird, MESH: Bird Diseases/pathology, Chick mortality, Animals, Wildlife management, MESH: Bird Diseases/epidemiology, 14. Life underwater, education, Ecology, Evolution, Behavior and Systematics, MESH: Alphaherpesvirinae/isolation & purification, 030304 developmental biology, Fregata magnificens, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, chick mortality, Outbreak, biology.organism_classification, MESH: Male, MESH: Herpesviridae Infections/epidemiology, MESH: Female
Abstract

International audience; The Ile du Grand Connétable nature reserve is a rocky island off the Northern Atlantic coast of South America that hosts a unique population of Magnificent Frigatebirds (Fregata magnificens, Pelecaniformes). A high chick mortality, associated with nodular proliferative lesions, involving featherless areas, such as legs, neck, eyelids, and beak, was recorded during a consecutive 2 yr and affected almost half of the generation. Investigations were, therefore, conducted to determine the cause of these epidemics. Although histopathologic investigations suggested that malnutrition, because of fewer resources in the Frigates' fishing area, could be the cause of the epidemic, a novel alphaherpesvirus, tentatively called Fregata magnificens herpesvirus, was detected in cutaneous crusts on the diseased birds. Although in this study, we do not prove the causal link of this new virus to the symptoms observed, it can nevertheless be suggested that in debilitated hosts, a productive herpesvirus infection might accelerate, and/or be accelerated by, population declines. These results emphasize the need to take into consideration the possible role of herpesviruses in weakened populations of wild birds in conservation management plans.

Published
2009

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