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Your search keyword '"MESH: Iron / metabolism"' showing total 3 results
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3 results on '"MESH: Iron / metabolism"'

1. Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Author

Belot, Audrey, Gourbeyre, Ophélie, Palin, Anais, Rubio, Aude, Largounez, Amélie, Besson-Fournier, Celine, Latour, Chloé, Lorgouilloux, Megane, Gallitz, Inka, Montagner, Alexandra, Polizzi, Arnaud, Régnier, Marion, Smati, Sarra, Zhang, An-Sheng, Diaz-Munoz, Manuel, Steinbicker, Andrea, Guillou, Hervé, Roth, Marie-Paule, Coppin, Hélène, Meynard, Delphine, Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Oregon Health and Science University [Portland] (OHSU), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cooley's Anemia Foundation, French Foundation for Rare Diseases, German Research Foundation (DFG) : STE-1985/4-1, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA : R01DK102791, ATIP-AVENIR (INSERM/CNRS) program, Plan-Cancer : C18003BS, ANR-15-CE14-0026,Hepatokind,FGF21 contrôle homéostasie glucidique via les facteurs de transcription ChREBP et PPARa(2015), ANR-17-CE14-0036,IRONASH,Rôle du fer dans la pathologie du NASH(2017), ANR-17-CE14-0031,MTREAT-2,Manipuler la Matriptase-2 pour traiter les pathologies associées à une dérégulation du métabolisme du fer(2017), ANR-11-EQPX-0003,ANINFIMIP,Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées(2011), LESUR, Hélène, FGF21 contrôle homéostasie glucidique via les facteurs de transcription ChREBP et PPARa - - Hepatokind2015 - ANR-15-CE14-0026 - AAPG2015 - VALID, Rôle du fer dans la pathologie du NASH - - IRONASH2017 - ANR-17-CE14-0036 - AAPG2017 - VALID, Manipuler la Matriptase-2 pour traiter les pathologies associées à une dérégulation du métabolisme du fer - - MTREAT-22017 - ANR-17-CE14-0031 - AAPG2017 - VALID, Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées - - ANINFIMIP2011 - ANR-11-EQPX-0003 - EQPX - VALID, and Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity)

Subjects
MESH: Humans, MESH: Membrane Proteins / genetics, Iron, Serine Endopeptidases, Membrane Proteins, RNA-Binding Proteins, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Endoplasmic Reticulum Stress, MESH: Serine Endopeptidases / genetics, MESH: Hepcidins* / metabolism, MESH: RNA-Binding Proteins, Hepcidins, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MESH: RNA, Messenger / genetics, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Humans, MESH: Endoplasmic Reticulum Stress* / genetics, MESH: Membrane Proteins / metabolism, RNA, Messenger, MESH: Hepcidins* / genetics, MESH: Iron / metabolism, Letters to the Editor, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; The liver hormone hepcidin controls the main inflows of iron into plasma by binding to and inducing the degradation or the occlusion of the iron export activity of ferroportin, the only known cellular exporter of iron. When hepcidin concentrations are high, iron is trapped in enterocytes of the duodenum, hepatocytes, and macrophages. Hepcidin production by the hepatocytes is induced by a number of stimuli, most notably iron, through the BMP-SMAD signaling pathway, and inflammatory signals, through the IL-6/ STAT3 signaling axis. In addition, hepcidin has also been reported to respond to intracellular stress, namely endoplasmic reticulum (ER) stress which is involved in a number of pathophysiological states, including the inflammatory response, nutrient disorders and viral infection. A previous study has suggested that hepcidin induction by ER stress is controlled by the BMP-SMAD pathway,5 but the exact mechanism is still uncertain

Published
2021
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2. Endocytosis in plants: Peculiarities and roles in the regulated trafficking of plant metal transporters

Author

Rumen Ivanov, Grégory Vert, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Signalisation Cellulaire et Ubiquitination, Laboratoire de Recherche en Sciences Végétales (LRSV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), ANR-13-JSV2-0004,Ubi63,Exploration du role de la polyubiquitination K63 en utilisant les plantes comme modèle(2013), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), and ANR-11-IDEX-0002,UNITI,Université Fédérale de Toulouse(2011)

Subjects
MESH: Cation Transport Proteins / metabolism, metal, MESH: Arabidopsis / metabolism, Iron, MESH: Biological Transport, Endocytic cycle, Arabidopsis, Endocytic recycling, Saccharomyces cerevisiae, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Endocytosis, MESH: Saccharomyces cerevisiae / metabolism, 03 medical and health sciences, 0302 clinical medicine, MESH: Arabidopsis Proteins / metabolism, Ubiquitin, ubiquitin, Animals, endocytosis, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Endomembrane system, MESH: Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Iron / metabolism, Cation Transport Proteins, 030304 developmental biology, degradation, Mammals, MESH: Cell Membrane / metabolism, 0303 health sciences, biology, Arabidopsis Proteins, Cell Membrane, Biological Transport, Receptor signaling, Transporter, Cell Biology, General Medicine, Transmembrane protein, Cell biology, MESH: Mammals / metabolism, biology.protein, IRT1, MESH: Endocytosis, 030217 neurology & neurosurgery
Abstract

International audience; The removal of transmembrane proteins from the plasma membrane via endocytosis has emerged as powerful strategy in the regulation of receptor signalling and molecule transport. In the last decade, IRON-REGULATED TRANSPORTER1 (IRT1) has been established as one of the key plant model proteins for studying endomembrane trafficking. The use of IRT1 and additional other metal transporters has uncovered novel factors involved in plant endocytosis and facilitated a better understanding of the role of endocytosis in the fine balancing of plant metal homoeostasis. In this review, we outline the specifics of plant endocytosis compared to what is known in yeast and mammals, and based on several examples, we demonstrate how studying metal transport has contributed to extending our knowledge of endocytic trafficking by shedding light on novel regulatory mechanisms and factors.

Published
2021
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3. Tissue-specific regulation of gibberellin signaling fine-tunes Arabidopsis iron deficiency responses

Author

Thomas Regnault, Anne Cayrel, Patrick Achard, Michael Wild, Guillaume Dubeaux, Grégory Vert, Esther Carrera, Isabel Díaz, Lali Sakvarelidze-Achard, Jean-Michel Davière, Institut de biologie moléculaire des plantes (IBMP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de València (UPV), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
0106 biological sciences, 0301 basic medicine, Arabidopsis thaliana, MESH: Arabidopsis / metabolism, Iron, MESH: Iron / metabolism, Arabidopsis, MESH: Basic Helix-Loop-Helix Transcription Factors / metabolism, MESH: Gibberellins / metabolism, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 01 natural sciences, Plant Roots, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Plant Growth Regulators, Gene Expression Regulation, Plant, Botany, medicine, Basic Helix-Loop-Helix Transcription Factors, Molecular Biology, Transcription factor, 2. Zero hunger, Rhizosphere, biology, Epidermis (botany), Arabidopsis Proteins, Iron deficiency, MESH: Plant Growth Regulators / pharmacology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Biology, MESH: Arabidopsis Proteins / metabolism, Meristem, biology.organism_classification, medicine.disease, FIT, Gibberellins, MESH: Gene Expression Regulation, Plant / physiology, Cell biology, 030104 developmental biology, Root epidermis, Gibberellin, DELLA, 010606 plant biology & botany, Developmental Biology
Abstract

International audience; Iron is an essential element for most living organisms. Plants acquire iron from the rhizosphere and have evolved different biochemical and developmental responses to adapt to a low-iron environment. In Arabidopsis, FIT encodes a basic helix-loop-helix transcription factor that activates the expression of iron-uptake genes in root epidermis upon iron deficiency. Here, we report that the gibberellin (GA) signaling DELLA repressors contribute substantially in the adaptive responses to iron-deficient conditions. When iron availability decreases, DELLAs accumulate in the root meristem, thereby restraining root growth, while being progressively excluded from epidermal cells in the root differentiation zone. Such DELLA exclusion from the site of iron acquisition relieves FIT from DELLA-dependent inhibition and therefore promotes iron uptake. Consistent with this mechanism, expression of a non-GA-degradable DELLA mutant protein in root epidermis interferes with iron acquisition. Hence, spatial distribution of DELLAs in roots is essential to fine-tune the adaptive responses to iron availability.

Published
2016
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