Descriptor: "MESH: Joints" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"MESH: Joints"' showing total 31 results

Start Over Descriptor "MESH: Joints"

31 results on '"MESH: Joints"'

1. Deriving stratified effects from joint models investigating Gene-Environment Interactions

Author: Mary F. Feitosa, DC Rao, Timothy D. Majarian, Vincent Laville, Hugues Aschard, Yun Ju Sung, Paul S. de Vries, Amy R. Bentley, Alisa K. Manning, Département de Biologie Computationnelle - Department of Computational Biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], The University of Texas Health Science Center at Houston (UTHealth), National Institutes of Health [Bethesda] (NIH), Washington University School of Medicine [Saint Louis, MO], Harvard T.H. Chan School of Public Health, This work was supported by the HL118305 grant from the NHLBI. HA was also supported by R21HG007687 from NHGRI. PSdV was supported by American Heart Association grant number 18CDA34110116. This research was supported in part by the Intramural Research Program of the National Human Genome Research Institute in the Center for Research in Genomics and Global Health (CRGGH—Z01HG200362). CRGGH is also supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Center for Information Technology, and the Office of the Director at the National Institutes of Health., Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), and Washington University School of Medecine [Saint Louis, MO]
Subjects: Computer science, Marginal model, lcsh:Computer applications to medicine. Medical informatics, Interaction, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Dummy variable, Statistics, Humans, Binary exposure, MESH: Models, Genetic, Gene–environment interaction, lcsh:QH301-705.5, Molecular Biology, 030304 developmental biology, [STAT.AP]Statistics [stat]/Applications [stat.AP], 0303 health sciences, MESH: Humans, Models, Genetic, Applied Mathematics, MESH: Gene-Environment Interaction, Estimator, Environmental exposure, Stratified analysis, Summary statistics, Gene-environment interaction, Computer Science Applications, Term (time), MESH: Joints, lcsh:Biology (General), [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Sample size determination, 030220 oncology & carcinogenesis, lcsh:R858-859.7, Joints, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [STAT.ME]Statistics [stat]/Methodology [stat.ME], Software, 030217 neurology & neurosurgery
Abstract: Background Models including an interaction term and performing a joint test of SNP and/or interaction effect are often used to discover Gene-Environment (GxE) interactions. When the environmental exposure is a binary variable, analyses from exposure-stratified models which consist of estimating genetic effect in unexposed and exposed individuals separately can be of interest. In large-scale consortia focusing on GxE interactions in which only the joint test has been performed, it may be challenging to get summary statistics from both exposure-stratified and marginal (i.e not accounting for interaction) models. Results In this work, we developed a simple framework to estimate summary statistics in each stratum of a binary exposure and in the marginal model using summary statistics from the “joint” model. We performed simulation studies to assess our estimators’ accuracy and examined potential sources of bias, such as correlation between genotype and exposure and differing phenotypic variances within exposure strata. Results from these simulations highlight the high theoretical accuracy of our estimators and yield insights into the impact of potential sources of bias. We then applied our methods to real data and demonstrate our estimators’ retained accuracy after filtering SNPs by sample size to mitigate potential bias. Conclusions These analyses demonstrated the accuracy of our method in estimating both stratified and marginal summary statistics from a joint model of gene-environment interaction. In addition to facilitating the interpretation of GxE screenings, this work could be used to guide further functional analyses. We provide a user-friendly Python script to apply this strategy to real datasets. The Python script and documentation are available at https://gitlab.pasteur.fr/statistical-genetics/j2s.
Published: 2019
Full Text: View/download PDF

2. Prognosis and follow-up of psoriatic arthritis with peripheral joint involvement: Development of recommendations for clinical practice based on published evidence and expert opinion

Author: Alain Cantagrel, Alain Saraux, Thierry Schaeverbeke, Jacques Tebib, Bernard Combe, Carle Paul, Philippe Gaudin, Philippe Goupille, F. Lavie, Daniel Wendling, Emmanuelle Dernis, Carine Salliot, Jean-Francis Maillefert, René-Marc Flipo, Pascal Claudepierre, Xavier Le Loët, CHU Cochin [APHP], Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Lariboisière - Université Paris Diderot - Paris 7 (UP7), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Pellegrin, CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin, Génétique, Immunothérapie, Chimie et Cancer (GICC), Université François Rabelais - Tours - Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF) - CHU Grenoble, CHU Dijon, Centre Hospitalier Universitaire de Dijon (CHU Dijon), Hôpital Lapeyronie, Université Montpellier 1 (UM1) - Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Hôpital Lapeyronie, Service de rhumatologie, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Service de rhumatologie [CHU Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, CHU Bordeaux [Bordeaux], Service d'immunologie et rhumatologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de Rhumatologie, Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital Lapeyronie [Montpellier] (CHU), CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Cambefort, Jeanne
Subjects: MESH: Inflammation, [SDV]Life Sciences [q-bio], Delphi method, Alternative medicine, MESH: Monitoring, Physiologic, Arthritis, Recommendations, 0302 clinical medicine, MESH: Arthritis, Psoriatic, 030212 general & internal medicine, Practice Patterns, Physicians', MESH: Publishing, Evidence-Based Medicine, Follow-up, MESH: Follow-Up Studies, Prognosis, MESH: Predictive Value of Tests, 3. Good health, [SDV] Life Sciences [q-bio], MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Psoriatic arthritis, Radiological weapon, Predictive value of tests, MESH: Expert Testimony, medicine.medical_specialty, MEDLINE, MESH: Prognosis, 03 medical and health sciences, Rheumatology, Predictive Value of Tests, medicine, Humans, MESH: Physician's Practice Patterns, Expert Testimony, Monitoring, Physiologic, Inflammation, Publishing, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Arthritis, Psoriatic, Everyday clinical practice, Evidence-based medicine, medicine.disease, Radiography, Physical therapy, Joints, business, MESH: Evidence-Based Medicine, Follow-Up Studies
Abstract: International audience; Objectives: To develop recommendations about prognosis and follow-up of psoriatic arthritis (PsA) with peripheral joint involvement in everyday clinical practice. Methods: The strategy was as following: (a) The choice of five questions, by the scientific committee according to the Delphi method, considered as a basis for the recommendations; (b) the Systematic Literature Research based on Medline, Cochrane and abstracts from the annual meetings of SFR, EULAR and ACR. An expert committee composed with 68 rheumatologists elaborated and validated the recommendations, specifying the strength and the degree of agreement for each of them. Results: The questions selected were: (1) How can articular and cutaneous disease activity of PsA be assessed in usual clinical practice? (2) Which parameters are predictive for functional, radiological and fatal outcome in PsA? (3) Which clinical and biological parameters are useful for the follow-up of PsA? At which frequency? (4) Which X-rays are useful for the follow-up of PsA? At which frequency? (5) How can the response to treatments be assessed in PsA? The literature search identified 1181 abstracts and 123 articles were included and analyzed. Seven recommendations, whose strength ranged from B to D, were drafted and validated by a final vote of the expert committee. Conclusion: Seven recommendations about follow-up of patients with PsA for daily practice were developed. They can be expected to improve clinical practice uniformity and, in the longer term, to optimize the management of patients with PsA. (C) 2009 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
Published: 2009
Full Text: View/download PDF

3. Computational Motor Control: Redundancy and Invariance

Author: Pierre Baraduc, Michel Desmurget, Emmanuel Guigon, Action-Neuroimagerie-Modelisation (ANIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Espace et Action, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR19-Institut National de la Santé et de la Recherche Médicale (INSERM), Cerveau et vision, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), and Guigon, Emmanuel
Subjects: Central Nervous System, MESH: Range of Motion, Articular, Inertial frame of reference, Optimality criterion, Physiology, Computer science, Elbow, MESH: Movement, Kinematics, Weight-Bearing, 0302 clinical medicine, MESH: Weight-Bearing, Redundancy (engineering), Biomechanics, MESH: Animals, Range of Motion, Articular, MESH: Arm, MESH: Biomechanics, MESH: Muscle, Skeletal, MESH: Feedback, General Neuroscience, 05 social sciences, Skeletal, Biomechanical Phenomena, MESH: Joints, medicine.anatomical_structure, Arm, Muscle, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Algorithms, Range of Motion, Movement, MESH: Algorithms, 050105 experimental psychology, Feedback, 03 medical and health sciences, MESH: Computer Simulation, Control theory, medicine, MESH: Central Nervous System, Animals, Humans, Computer Simulation, 0501 psychology and cognitive sciences, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Muscle, Skeletal, Scaling, MESH: Humans, Motor control, Nonlinear system, Joints, 030217 neurology & neurosurgery, Articular
Abstract: International audience; The nervous system controls the behavior of complex kinematically redundant biomechanical systems. How it computes appropriate commands to generate movements is unknown. Here we propose a model based on the assumption that the nervous system: 1) processes static (e.g., gravitational) and dynamic (e.g., inertial) forces separately; 2) calculates appropriate dynamic controls to master the dynamic forces and progress toward the goal according to principles of optimal feedback control; 3) uses the size of the dynamic commands (effort) as an optimality criterion; and 4) can specify movement duration from a given level of effort. The model was used to control kinematic chains with 2, 4, and 7 degrees of freedom [planar shoulder/elbow, three-dimensional (3D) shoulder/elbow, 3D shoulder/elbow/wrist] actuated by pairs of antagonist muscles. The muscles were modeled as second-order nonlinear filters and received the dynamics commands as inputs. Simulations showed that the model can quantitatively reproduce characteristic features of pointing and grasping movements in 3D space, i.e., trajectory, velocity profile, and final posture. Furthermore, it accounted for amplitude/duration scaling and kinematic invariance for distance and load. These results suggest that motor control could be explained in terms of a limited set of computational principles.
Published: 2007
Full Text: View/download PDF

4. Respective interest of T2 mapping and diffusion tensor imaging in assessing porcine knee cartilage with MR at 3 Teslas

Author: Jacques Felblinger, Pierre Gillet, Emilie Roeder, Astrid Pinzano, Pierre-André Vuissoz, Bailiang Chen, Marine Beaumont, Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'Investigation Clinique - Innovation Technologique [Nancy] (CIC-IT), Centre d'investigation clinique [Nancy] (CIC), and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
Subjects: Cartilage, Articular, Models, Anatomic, MESH: Echo-Planar Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Swine, T2 mapping, Osteoarthritis, MESH: Models, Anatomic, Menisci, Tibial, 030218 nuclear medicine & medical imaging, MESH: Magnetic Resonance Imaging, 0302 clinical medicine, MESH: Osteoarthritis, Image Processing, Computer-Assisted, MESH: Animals, Femur, MESH: Swine, ComputingMilieux_MISCELLANEOUS, medicine.diagnostic_test, Echo-Planar Imaging, MESH: Hindlimb, General Medicine, Anatomy, MESH: Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Knee cartilage, Hindlimb, MESH: Joints, MESH: Femur, medicine.anatomical_structure, Diffusion Tensor Imaging, MESH: Models, Animal, 030220 oncology & carcinogenesis, Models, Animal, MESH: Image Enhancement, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, MESH: Diffusion Tensor Imaging, Materials science, Biomedical Engineering, MESH: Imaging, Three-Dimensional, MESH: Menisci, Tibial, Biomaterials, 03 medical and health sciences, Imaging, Three-Dimensional, Fractional anisotropy, medicine, Effective diffusion coefficient, Animals, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Cartilage, Magnetic resonance imaging, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, medicine.disease, Image Enhancement, MESH: Cartilage, Articular, MESH: Anisotropy, Anisotropy, Feasibility Studies, Joints, MESH: Feasibility Studies, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Biomedical engineering, Diffusion MRI
Abstract: International audience; Non-invasive quantitative assessment of articular cartilage integrity is essential for early detection and evaluation of osteoarthritis (OA) and for the follow-up of stem-cell-driven cartilage engineering. In this study, we investigated the feasibility of exploiting diffusion tensor imaging (DTI) on porcine knee joints with a clinical magnetic resonance (MR) scanner to extract micro-structural information in order to complement biochemical information quantified by T2 maps. We propose an MR protocol for quantifying T2 and cartilage microstructure with diffusion MR on a clinical scanner. Preliminary results were obtained on four pig knee joints using a 3 T GE clinical MRI scanner and an 8-channel knee coil array. The measured cartilage volume, T2 values, apparent diffusion coefficient and fractional anisotropy (FA) of femoral and tibial cartilage were respectively 9.8/2.3 mm2, 67.0/56.1 ms, 1.3/1.3×10-3 mm2/s and 0.4/0.3. This new protocol has the potential to be combined in vivo with quantitative assessment of both cartilage degradation and restoration in osteoarthritis.
Published: 2013
Full Text: View/download PDF

5. The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound

Author: Maxime, Dougados, Valérie, Devauchelle-Pensec, Jean François, Ferlet, Sandrine, Jousse-Joulin, Maria-Antonietta, D'Agostino, Marina, Backhaus, Jacques, Bentin, Gérard, Chalès, Isabelle, Chary-Valckenaere, Philip, Conaghan, Richard J, Wakefield, Fabien, Etchepare, Frédéric, Etcheparre, Philippe, Gaudin, Walter, Grassi, Désirée van der, Heijde, Xavier, Mariette, Esperanza, Naredo, Marcin, Szkudlarek, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Statistique, RCTS, Lyon, RCTS Lyon, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Service de Rhumatologie, CHU Brugmann, CHU Brugmann, Belgium, CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Section of Musculoskeletal Diseasee, University of Leeds, Academic Unit of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Rhumatologie [CHU de Grenoble], Hôpital Sud de Grenoble, Univ Ancona, Politecn Marche, Leiden University Medical Center (LUMC), Universiteit Leiden, CHU Le Kremlin-Bicêtre (Rheumatology Department), Department of Rheumatology, Severo Ochoa Hospital, Hvidovre University Hospital, and University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit
Subjects: Male, Settore MED/16 - REUMATOLOGIA, MESH: Synovitis, Arthritis, Rheumatoid, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Rheumatoid, Immunologie, Immunology and Allergy, Medicine, 030212 general & internal medicine, Longitudinal Studies, Prospective Studies, Prospective cohort study, MESH: Longitudinal Studies, Ultrasonography, MESH: Aged, MESH: Arthritis, Rheumatoid, Synovitis, MESH: Middle Aged, medicine.diagnostic_test, Ultrasound, Doppler, MESH: Follow-Up Studies, Middle Aged, Connective tissue disease, MESH: Predictive Value of Tests, 3. Good health, MESH: Reproducibility of Results, Rhumatologie, MESH: Joints, Rheumatoid arthritis, Predictive value of tests, Disease Progression, Female, MESH: Disease Progression, Radiology, Biologie, Adult, medicine.medical_specialty, Allergie et immunopathologie, Immunology, Physical examination, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Power doppler, MESH: Physical Examination, Rheumatology, Predictive Value of Tests, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Physical Examination, Aged, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Arthritis, Reproducibility of Results, Ultrasonography, Doppler, MESH: Adult, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Clinical and Epidemiological Research, medicine.disease, MESH: Prospective Studies, MESH: Male, Surgery, MESH: Ultrasonography, Doppler, Joints, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract: Objectives To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA). Methods Patients with RA. Study design Prospective, 2-year follow-up. Data collected Synovitis (32 joints (2 wrists, 10 metacarpophalangeal, 10 proximal interphalangeal, 10 metatarsophalangeal)) at baseline and after 4 months of therapy by clinical, US grey scale (GS-US) and power doppler (PD-US); x-rays at baseline and at year 2. Analysis Measures of association (OR) were tested between structural deterioration and the presence of baseline synovitis, or its persistence, after 4 months of therapy using generalised estimating equation analysis. Results Structural deterioration was observed in 9% of the 1888 evaluated joints in 59 patients. Baseline synovitis increased the risk of structural progression: OR=2.01 (1.36-2.98) p, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2013
Full Text: View/download PDF

6. Can remission in rheumatoid arthritis be assessed without laboratory tests or a formal joint count? possible remission criteria based on a self-report RAPID3 score and careful joint examination in the ESPOIR cohort

Author: Bernard Combe, Bruno Fautrel, Isabel Castrejón, Maxime Dougados, Francis Guillemin, Theodore Pincus, Division of Rheumatology (NYU Hospital - Rheumato), New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU)-NYU System (NYU), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université de Montpellier (UM)-Université Montpellier 1 (UM1), Division of Rheumatology ( NYU Hospital - Rheumato ), New York University Hospital, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - IURC, Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Diderot - Paris 7 ( UPD7 ), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 ( AIDMP ), and Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC )
Subjects: Male, MESH: Antirheumatic Agents, MESH: Remission Induction, [SDV]Life Sciences [q-bio], Severity of Illness Index, Arthritis, Rheumatoid, Disability Evaluation, 0302 clinical medicine, Cohen's kappa, Remission criteria, Surveys and Questionnaires, Immunology and Allergy, MESH : Female, 030212 general & internal medicine, MESH : Joints, MESH: Treatment Outcome, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, MESH : Physical Examination, Remission Induction, MESH: Disability Evaluation, MESH : Questionnaires, MESH : Adult, Middle Aged, Joint examination, MESH : Antirheumatic Agents, 3. Good health, MESH: Diagnostic Self Evaluation, MESH: Joints, C-Reactive Protein, Treatment Outcome, Rheumatoid arthritis, Antirheumatic Agents, Cohort, MESH : Severity of Illness Index, Female, MESH : Sensitivity and Specificity, Adult, musculoskeletal diseases, medicine.medical_specialty, MESH : Male, Immunology, MESH : Disability Evaluation, MESH : Treatment Outcome, Sensitivity and Specificity, 03 medical and health sciences, Diagnostic Self Evaluation, MESH: Physical Examination, Rheumatology, Internal medicine, MESH: Severity of Illness Index, MESH: C-Reactive Protein, medicine, Humans, MESH : Middle Aged, Physical Examination, 030203 arthritis & rheumatology, MESH : Remission Induction, MESH: Humans, [ SDV ] Life Sciences [q-bio], MESH : Diagnostic Self Evaluation, business.industry, MESH: Questionnaires, MESH : Humans, MESH: Adult, MESH : C-Reactive Protein, medicine.disease, MESH: Sensitivity and Specificity, MESH: Male, MESH : Arthritis, Rheumatoid, Physical therapy, Joints, business, MESH: Female, Rheumatism, Kappa
Abstract: Objective.To explore 5 possible criteria for remission in rheumatoid arthritis (RA) based on a patient self-report index, the Routine Assessment of Patient Index Data (RAPID3), with a careful joint examination and possible physician global estimate (DOCGL), but without a formal joint count or laboratory test.Methods.The ESPOIR early RA cohort of 813 French patients recruited in 2002–2005 was analyzed to identify patients in remission 6 months after enrollment, according to 2 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria: Boolean ≤ 1 for total tender joint count-28, swollen joint count-28, C-reactive protein, and patient global estimate (PATGL), and Simplified Disease Activity Index (SDAI) ≤ 3.3. Agreement with 7 other remission criteria was analyzed — Disease Activity Score-28 (DAS28) ≤ 2.6, Clinical Disease Activity Index (CDAI) ≤ 2.8, and 5 candidate criteria based on RAPID3, joint examination, and DOCGL: “RAPID3R” (RAPID3 ≤ 3.0); “RAPID3R+SJ1” (RAPID3 ≤ 3.0, ≤ 1 swollen joint); “RAPID3R+SJ1+D1” (RAPID3 ≤ 3.0, ≤ 1 swollen joint, DOCGL ≤ 1); “RAPID3R+SJ0” (RAPID3 ≤ 3.0, 0 swollen joints); and “RAPID3R+SJ0+D1” (RAPID3 ≤ 3.0, 0 swollen joints, DOCGL ≤ 1), according to kappa statistics, sensitivity, and specificity. Residual global, articular, and questionnaire abnormalities according to each criteria set were analyzed.Results.Among 813 ESPOIR patients, 720 had complete data to compare all 9 possible criteria. Substantial agreement with the Boolean criteria was seen for SDAI, CDAI, RAPID3R+SJ1, RAPID3R+SJ1+D1, RAPID3R+SJ0, and RAPID3R+SJ0+D1 (92.2%–94.7%, kappa 0.67–0.79), versus only moderate agreement for DAS28 or RAPID3R (79.9%–85.8%, kappa 0.46–0.55).Conclusion.Remission according to CDAI and RAPID3R+SJ1, but not DAS28 or RAPID3R, is similar to that of the ACR/EULAR criteria. RAPID3 scores require a complementary careful joint examination for clinical decisions, do not preclude formal joint counts or other indices, and may be useful in busy clinical settings.
Published: 2013
Full Text: View/download PDF

7. Improving agreement in assessment of synovitis in rheumatoid arthritis

Author: Peter P. Cheung, Emmanuel Chatelus, François Pouyol, Adeline Ruyssen-Witrand, Laure Gossec, Mélanie Gilson, Sandrine Guis, Martin Soubrier, Nathalie Balandraud, Thierry Marhadour, Pascal Richette, Ghislaine Gill, Isabelle Chary-Valckenaere, Stephan Pavy, Emmanuelle Dernis, Vincent André, Gérard Chalès, Gaël Mouterde, Maxime Dougados, National University Health System, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Centre Hospitalier du Mans, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), CHU Pontchaillou [Rennes], Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Rhumatologie, Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de Référence pour les Maladies Systémiques Autoimmunes Rares, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Lapeyronie, Service de rhumatologie, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Roger Salengro, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), AP-HP, pôle appareil locomoteur, Service de rhumatologie, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], CHU Gabriel Montpied (CHU), CHU Clermont-Ferrand, National University Health System [Singapore] (NUHS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Roger Salengro [Lille], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHU Gabriel Montpied [Clermont-Ferrand], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Paris Descartes - Faculté de Médecine ( UPD5 Médecine ), Université Paris Descartes - Paris 5 ( UPD5 ), Hôpital Sainte-Marguerite [CHU - APHM] ( Hôpitaux Sud ), Ingénierie Moléculaire et Physiopathologie Articulaire ( IMoPA ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, Centre de résonance magnétique biologique et médicale ( CRMBM ), Aix Marseille Université ( AMU ) -Assistance Publique - Hôpitaux de Marseille ( APHM ) -Centre National de la Recherche Scientifique ( CNRS ), CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 ( UPD7 ), and CHU Gabriel Montpied ( CHU )
Subjects: Male, MESH: Synovitis, MESH : Aged, Arthritis, MESH: Observer Variation, Severity of Illness Index, MESH : Consensus, Arthritis, Rheumatoid, MESH : Cross-Sectional Studies, [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 0302 clinical medicine, Medicine, MESH : Female, 030212 general & internal medicine, skin and connective tissue diseases, MESH : Joints, MESH : Synovitis, Observer Variation, MESH: Aged, MESH: Arthritis, Rheumatoid, Synovitis, MESH: Middle Aged, medicine.diagnostic_test, Swollen joints, MESH : Adult, Middle Aged, 3. Good health, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], MESH: Reproducibility of Results, MESH: Joints, Rheumatoid arthritis, MESH : Severity of Illness Index, Female, Clinical Competence, MESH: Clinical Competence, Clinical competence, Adult, musculoskeletal diseases, medicine.medical_specialty, Validation study, Consensus, MESH : Male, Physical examination, [ SDV.BBM.BM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, 03 medical and health sciences, MESH: Cross-Sectional Studies, Rheumatology, MESH: Rheumatology, MESH: Severity of Illness Index, Humans, MESH : Middle Aged, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Consensus, MESH : Rheumatology, Aged, 030203 arthritis & rheumatology, MESH: Humans, business.industry, MESH : Reproducibility of Results, MESH : Humans, Reproducibility of Results, MESH: Adult, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, MESH : Observer Variation, medicine.disease, MESH : Clinical Competence, MESH: Male, Cross-Sectional Studies, MESH : Arthritis, Rheumatoid, Physical therapy, Joints, Treatment decision making, business, MESH: Female
Abstract: International audience; Synovitis assessment through evaluation of swollen joints is integral in steering treatment decisions in rheumatoid arthritis (RA). However, there is high inter-observer variation. The objective was to assess if a short collegiate consensus would improve swollen joint agreement between rheumatologists and whether this was affected by experience.; Eighteen rheumatologists from French university rheumatology units participated in three 30 minutes rounds over a half day meeting evaluating joint counts of RA patients in small groups, followed by short consensus discussions. Agreement was evaluated at the end of each round as follows: (i) global agreement of swollen joints (ii) swollen joint agreement according to level of experience of the rheumatologist (iii) swollen joint count and (iv) agreement of disease activity state according to the Disease Activity Score (DAS28). Agreement was calculated using percentage agreement and kappa.; Global agreement of swollen joints failed to improve (kappa 0.50 to 0.52) at the joint level. Agreement between seniors did not improve but agreement between newly qualified rheumatologists and their senior peer, which was initially poor (kappa 0.28), improved significantly (to 0.54) at the end of the consensus exercises. Concordance of DAS28 activity states improved from 71% to 87%.; Consensus exercises for swollen joint assessment is worthwhile and may potentially improve agreement between clinicians in clinical synovitis and disease activity state, benefit was mostly observed in newly qualified rheumatologists.
Published: 2013
Full Text: View/download PDF

8. EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria

Author: Tore K Kvien, David T. Felson, Cédric Lukas, Ewa Stanislawska-Biernat, Josef S Smolen, Robert Landewé, Alan J. Silman, Paul Emery, Bernard Combe, Maxime Dougados, Daniel Aletaha, Angela Zink, Désirée van der Heijde, Iain B. McInnes, Clifton O. Bingham, Annette H M van der Helm-van Mil, Rachel Knevel, Gerd Burmester, Department of Rheumatology, Leiden University Medical Center (LUMC), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Cochin], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), University of Leeds, Tufts University School of Medicine [Boston], Diakonhjemmet Hospital, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, ARC Epidemiology Unit, The University of Manchester, Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Centre d'Investigation Clinique INSERM 1412 (CIC 1412 - BREST), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), The University of North Carolina at Chapel Hill, Charité - University Medicine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ), Service de Rhumatologie [CHU Cochin], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie, Centre d'Investigation Clinique INSERM 1412 ( CIC 1412 - BREST ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Lymphocyte B et Auto-immunité ( LBAI ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato )
Subjects: musculoskeletal diseases, medicine.medical_specialty, MESH: Antirheumatic Agents, Inflammatory arthritis, [SDV]Life Sciences [q-bio], Immunology, MESH : Europe, Arthritis, Metatarsophalangeal joints, Context (language use), General Biochemistry, Genetics and Molecular Biology, Arthritis, Rheumatoid, [ SDV.MHEP.RSOA ] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatology, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, MESH: Rheumatology, medicine, Humans, Immunology and Allergy, skin and connective tissue diseases, MESH : Rheumatology, MESH : Joints, MESH : Evidence-Based Medicine, MESH: Arthritis, Rheumatoid, Evidence-Based Medicine, MESH: Humans, [ SDV ] Life Sciences [q-bio], business.industry, MESH : Humans, medicine.disease, MESH : Antirheumatic Agents, Europe, MESH: Joints, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Rheumatoid arthritis, Cohort, MESH : Arthritis, Rheumatoid, Physical therapy, Joints, MESH: Europe, business, Rheumatism, MESH: Evidence-Based Medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was formed including 16 rheumatologists and one rheumatology fellow. The process was both evidence based and consensus based, and included, between March 2010 and April 2012, analyses of data from two cohorts, two face-to-face meetings, one online voting and one teleconference. The Leiden Early Arthritis Cohort and the French ESPOIR cohort were used for the evidence-based part. The outcome measures, which were initiation of methotrexate therapy, or any disease-modifying antirheumatic drug therapy within the first year of disease and arthritis persistency over 5 years, were studied with the aim to give the best definition of erosive disease. A decision was made to select a definition with a high specificity and focus on patients who did not otherwise fulfil the 2010 ACR/EULAR RA criteria (
Published: 2013

9. Effect of adherence to European treatment recommendations on early arthritis outcome: data from the ESPOIR cohort

Author: Bruno Fautrel, Cécile Escalas, Bernard Combe, Philippe Ravaud, Pierre Durieux, Marie Dalichampt, Francis Guillemin, Maxime Dougados, Institut de Génétique Moléculaire de Montpellier ( IGMM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Rhumatologie, Université Paris Diderot - Paris 7 ( UPD7 ), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Service de rhumatologie [CHU Cochin], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Centre d'Investigation Clinique ( CIC - Brest ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université Paris Diderot - Paris 7 (UPD7), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP]
Subjects: Male, MESH: Antirheumatic Agents, MESH : Prospective Studies, MESH: Logistic Models, MESH : Arthrography, 0302 clinical medicine, MESH: Practice Guidelines as Topic, Epidemiology, Clinical endpoint, MESH: Arthrography, Immunology and Allergy, MESH : Female, 030212 general & internal medicine, Prospective Studies, Arthrography, MESH : Propensity Score, MESH : Joints, MESH: Treatment Outcome, education.field_of_study, MESH: Middle Aged, MESH : Prognosis, Middle Aged, Prognosis, MESH: Patient Compliance, MESH : Antirheumatic Agents, 3. Good health, MESH: Joints, MESH : Practice Guidelines as Topic, Treatment Outcome, Antirheumatic Agents, Cohort, Practice Guidelines as Topic, Disease Progression, Female, MESH: Disease Progression, Cohort study, medicine.medical_specialty, MESH : Male, Immunology, Population, MESH: Arthritis, MESH : Treatment Outcome, General Biochemistry, Genetics and Molecular Biology, MESH: Prognosis, MESH : Patient Compliance, 03 medical and health sciences, Rheumatology, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, medicine, Humans, MESH : Middle Aged, education, Propensity Score, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Arthritis, MESH : Humans, MESH : Arthritis, MESH : Disease Progression, MESH: Propensity Score, medicine.disease, MESH: Prospective Studies, MESH: Male, Logistic Models, Propensity score matching, Physical therapy, Patient Compliance, Observational study, Joints, business, MESH: Female, Rheumatism, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH : Logistic Models
Abstract: ObjectiveTo assess the association of adherence to the 2007 recommendations of the European League Against Rheumatism (EULAR) for managing early arthritis and radiographic progression and disability in patientsMethodsThe authors conducted a prospective population-based cohort study. The ESPOIR cohort was a French cohort of 813 patients with early arthritis not receiving disease-modifying antirheumatic drugs (DMARDs). Adherence to the 2007 EULAR recommendations was defined by measuring adherence to three of the recommendations concerning the initiation and early adjustment of DMARDs. The study endpoints were radiographic progression, defined as the presence of at least one new erosion between baseline and 1 year, and disability as a heath assessment questionnaire score ≥1 at 2 years. A propensity score of being treated according to the recommendations was developed.ResultsAfter adjustment for propensity score, treatment centre and the main confounding factors, patients without recommendation adherence were at increased risk of radiographic progression at 1 year, and of functional impairment at 2 years (OR 1.98, (95% CI: 1.08 to 3.62 and OR: 2.36, (95% CI: 1.17 to 4.67), respectively).ConclusionsEarly arthritis patients whose treatment adhered to the 2007 EULAR recommendations seemed to benefit from such treatment in terms of risk of clinical and radiographic progression. Using a propensity score of being treated according to recommendations in observational studies may be useful in assessing the potential impact of these recommendations on outcome.
Published: 2012
Full Text: View/download PDF

10. Prediction of radiographic damage in early arthritis by sonographic erosions and power Doppler signal: a longitudinal observational study

Author: Funck-Brentano, Thomas, Gandjbakhch, Frédérique, Etchepare, Fabien, Jousse-Joulin, Sandrine, Miquel, Anne, Cyteval, Catherine, Lukas, Cédric, Tobón, Gabriel J, Saraux, Alain, Boumier, Patrick, Goupille, Philippe, Bourgeois, Pierre, Fautrel, Bruno, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Lapeyronie [Montpellier] (CHU), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP], Service de Rhumatologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Pitié-Salpêtrière [APHP], Université de Brest (UBO) - IFR148, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Hôpital Lapeyronie, Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM), and Service de rhumatologie [Tours]
Subjects: Adult, Male, Metatarsophalangeal Joint, Time Factors, [SDV]Life Sciences [q-bio], MESH: Arthritis, Severity of Illness Index, MESH: Prognosis, Cohort Studies, Metacarpophalangeal Joint, Predictive Value of Tests, MESH: Severity of Illness Index, Outcome Assessment, Health Care, MESH: Arthrography, Humans, MESH: Metacarpophalangeal Joint, Longitudinal Studies, MESH: Longitudinal Studies, Arthrography, MESH: Outcome Assessment (Health Care), MESH: Cohort Studies, MESH: Middle Aged, MESH: Humans, Arthritis, MESH: Time Factors, MESH: Adult, Ultrasonography, Doppler, Middle Aged, Prognosis, MESH: Metatarsophalangeal Joint, MESH: Predictive Value of Tests, MESH: Male, [SDV] Life Sciences [q-bio], MESH: Joints, MESH: Ultrasonography, Doppler, Disease Progression, MESH: Disease Progression, Female, Joints, MESH: Female
Abstract: International audience; OBJECTIVE: To assess the ability of ultrasonography (US) to predict radiographic damage in early arthritis. METHODS: ESPOIR is a multicentric cohort of early arthritis (i.e., ≥2 swollen joints between 6 weeks and 6 months). US synovitis in B mode, power Doppler (PD) mode, and erosions were searched on the second through the fifth metacarpophalangeal and fifth metatarsophalangeal joints according to Outcome Measures in Rheumatology definitions. Structural radiographic progression was assessed using the modified Sharp/van der Heijde erosion score (SHS) at baseline and 1 and 2 years. Predictive factors of erosive arthritis at 2 years and rapid radiographic progression (RRP) at 1 year (defined by change of SHS ≥5) were searched. RESULTS: A total of 127 patients were included, with a mean ± SD Disease Activity Score in 28 joints of 5.1 ± 1.3; 37.6% were anti-citrullinated protein antibody positive and 27.6% had typical rheumatoid arthritis (RA) erosions on radiographs. At 2 years, 42 patients (39.2%) had typical RA erosions. US erosions predicted radiographic evidence of erosive arthritis (odds ratio [OR] 1.44, 95% confidence interval [95% CI] 1.04-1.98). PD synovitis score was predictive of RRP at 1 year (OR 1.22, 95% CI 1.04-1.42). US erosions and PD synovitis scores were associated with change of SHS on linear regression. Of the 1,184 analyzed joints, 105 (8.9%) had radiographic erosion at 1 year. At the joint level, baseline US erosions were predictive of the presence of radiographic erosions at 1 year (P < 0.001). The same trend was observed in the joints without radiographic erosions at baseline (P = 0.052). CONCLUSION: US is useful to evaluate the potential severity of early arthritis: US erosions and PD-positive synovitis have prognostic value to predict future radiographic damage.
Published: 2012
Full Text: View/download PDF

11. Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

Author: Pascale Roux-Lombard, Alain Cantagrel, Xavier Mariette, Gilles Chiocchia, Jacques-Eric Gottenberg, Beatrice Ducot, Cédric Lukas, Alain Saraux, Jean-Michel Dayer, Service de rhumatologie, Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre, Division of Immunology and Allergy, University Hospital, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie, Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Rhumatologie ( Toulouse - Rhumato ), CHU Toulouse [Toulouse], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Centre d'Investigation Clinique ( CIC - Brest ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service d'Immunologie et d'Allergologie ( SIA - GENEVE ), Hôpitaux Universitaires de Genève ( HUG ), Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Rhumatologie (Toulouse - Rhumato), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Immunologie et d'Allergologie (SIA - GENEVE), Hôpitaux Universitaires de Genève (HUG), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre
Subjects: Male, MESH : Prospective Studies, Arthritis, Lymphocyte Activation, MESH : Early Diagnosis, Arthritis, Rheumatoid, 0302 clinical medicine, MESH: Early Diagnosis, Outcome Assessment, Health Care, Immunology and Allergy, MESH : Female, Prospective Studies, Biological Markers/blood, MESH : Joints, ddc:616, 0303 health sciences, B-Lymphocytes, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, biology, medicine.diagnostic_test, Interleukin, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH : Adult, Middle Aged, Connective tissue disease, 3. Good health, MESH: Joints, Hyperalgesia, Rheumatoid arthritis, Erythrocyte sedimentation rate, Female, Adult, medicine.medical_specialty, MESH: Interleukins, MESH : Outcome Assessment (Health Care), MESH : Interleukin-6, MESH : Male, Immunology, General Biochemistry, Genetics and Molecular Biology, MESH : B-Lymphocytes, 03 medical and health sciences, Outcome Assessment (Health Care), Rheumatology, Internal medicine, MESH: B-Lymphocytes, medicine, MESH : Hyperalgesia, Hyperalgesia/pathology/physiopathology, Rheumatoid factor, Humans, MESH : Middle Aged, Joints/pathology/physiopathology, Arthritis, Rheumatoid/blood/diagnosis/immunology, Interleukin 6, MESH: Lymphocyte Activation, MESH: Outcome Assessment (Health Care), MESH : Lymphocyte Activation, 030304 developmental biology, B-Lymphocytes/immunology/metabolism/pathology, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Interleukin-6, Interleukins, MESH : Humans, MESH: Biological Markers, MESH: Adult, Interleukins/blood, medicine.disease, MESH: Hyperalgesia, MESH: Interleukin-6, MESH: Male, MESH: Prospective Studies, MESH : Biological Markers, Early Diagnosis, MESH : Arthritis, Rheumatoid, biology.protein, Joints, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Interleukin-6/blood, business, MESH : Interleukins, MESH: Female, Biomarkers
Abstract: International audience; OBJECTIVE: To identify a specific pattern of serum cytokines that correlates with the diagnosis, activity and severity of rheumatoid arthritis (RA) in patients with early RA as well as with the level of serum markers of B cell activation. METHODS: Serum interleukin (IL)-1β, IL-1 receptor antagonist (IL1-Ra), IL-2, IL-4, IL-6, IL-10, IL-17, IL-21, monocyte chemotactic protein 1 (MCP-1), tumour necrosis factor α and interferon γ levels were measured in the (ESPOIR) Etude et Suivi des POlyarthrites Indifférenciées Récentes early arthritis cohort, which included patients with at least two swollen joints for >6 weeks and
Published: 2012
Full Text: View/download PDF

12. Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis

Author: Alain Saraux, Loic de Parscau, Sandrine Jousse-Joulin, Luc Bressolette, Sylvain Breton, Danielle Colin, Claire Cangemi, Valérie Devauchelle-Pensec, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Réseau Maladies Métaboliques, Hôpitaux Universitaires du Grand Ouest, Service de Pédiatrie et Génétique Médicale, Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), and CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato)
Subjects: Male, MESH: Range of Motion, Articular, MESH: Synovitis, Arthritis, Severity of Illness Index, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, MESH: Child, Range of Motion, Articular, Child, Ultrasonography, Synovitis, medicine.diagnostic_test, 3. Good health, MESH: Joints, medicine.anatomical_structure, Joint pain, Child, Preschool, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Radiology, medicine.symptom, musculoskeletal diseases, medicine.medical_specialty, Adolescent, Physical examination, MESH: Physical Examination, 03 medical and health sciences, Rheumatology, MESH: Severity of Illness Index, Internal medicine, medicine, Synovial fluid, Humans, Physical Examination, MESH: Adolescent, 030203 arthritis & rheumatology, MESH: Humans, business.industry, MESH: Child, Preschool, Metacarpophalangeal joint, medicine.disease, MESH: Male, Arthritis, Juvenile, Surgery, Anesthesiology and Pain Medicine, MESH: Arthritis, Juvenile Rheumatoid, Joints, business, MESH: Female, Juvenile rheumatoid arthritis
Abstract: International audience; OBJECTIVES: The characteristics of synovitis in juvenile idiopathic arthritis (JIA) are important to evaluate, as they define several clinical categories. The metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints are frequently involved. Few studies have investigated peripheral joint evaluation using ultrasonography, a sensitive tool for detecting subclinical synovitis. Our objectives here were to compare clinical and ultrasound evaluations of MCP and MTP joint synovitis and to determine the prevalence of predefined ultrasound abnormalities in JIA patients and healthy controls. METHODS: Standardized physical and ultrasound assessments of the same joints were done in 31 consecutive patients with JIA and 41 healthy volunteers. Joint pain, motion limitation, and swelling were recorded. Ultrasonography was performed on the same joints by 2 trained sonographers who recorded synovial fluid, synovial hypertrophy, erosion, and power Doppler signal. Intraobserver reproducibility of ultrasonography was assessed. RESULTS: Of 558 peripheral joints examined in JIA patients, 69 (12.5%) had ultrasonographic synovitis and 83 (15%) had abnormal physical findings. All the physical abnormalities were significantly associated with ultrasonographic synovitis (P < 0.0001) but agreement was low between ultrasonographic and physical findings. Ultrasonographic synovitis was most common at the feet (59.4%), where it was detected clinically in only 25% of cases. Ultrasonographic synovitis was associated with the presence of synovial fluid. Cartilage vascularization was found in 2 (4.2%) healthy controls. CONCLUSION: Ultrasonography is useful for monitoring synovitis in JIA. Subclinical involvement of the MTP joints is common. Clinicians should be aware of the specific ultrasonographic findings in children.
Published: 2010
Full Text: View/download PDF

13. Reproducibility of joint swelling assessment by sonography in patients with long-lasting rheumatoid arthritis (SEA-Repro study part II)

Author: Christophe Hudry, Jérémie Sellam, Maxime Dougados, M.A. D'Agostino, F. Etchepare, Cécile Hacquard, Isabelle Chary Valckenaere, Gérard Chalès, Jean David Albert, Sandrine Jousse-Joulin, Laurent Grange, Alain Saraux, Thierry Marhadour, Jacques Bentin, Damien Loeuille, Philippe Gaudin, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service de Rhumatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Service de rhumatologie [Rennes] = Rheumatology [Rennes], CHU Pontchaillou [Rennes], Service de Rhumatologie, CHU Brugmann, CHU Brugmann, Belgium, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiopathologie, Pharmacologie et Ingénierie articulaires (PPIA), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, Service de rhumatologie, Hôpital Sud, Service de Rhumatologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Ambroise Paré, Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiopathologie, Pharmacologie et Ingénierie articulaires ( PPIA ), Université Henri Poincaré - Nancy 1 ( UHP ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP]
Subjects: Male, Settore MED/16 - REUMATOLOGIA, MESH: Synovitis, MESH : Aged, Severity of Illness Index, Arthritis, Rheumatoid, 0302 clinical medicine, Cohen's kappa, Rheumatoid, Immunology and Allergy, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH : Female, 030212 general & internal medicine, Disease activity, MESH : Joints, Ultrasonography, MESH : Synovitis, MESH: Aged, MESH: Arthritis, Rheumatoid, Synovitis, MESH: Middle Aged, medicine.diagnostic_test, Doppler, Middle Aged, Reference Standards, MESH : Ultrasonography, Doppler, MESH: Reproducibility of Results, MESH: Joints, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH : Severity of Illness Index, Female, MESH: Reference Standards, Long lasting, medicine.medical_specialty, MESH : Male, Immunology, Physical examination, 03 medical and health sciences, Rheumatology, MESH: Severity of Illness Index, Ultrasound, medicine, Humans, In patient, MESH : Middle Aged, Aged, 030203 arthritis & rheumatology, Reproducibility, MESH: Humans, business.industry, MESH : Reproducibility of Results, Arthritis, MESH : Humans, Reproducibility of Results, Ultrasonography, Doppler, medicine.disease, MESH: Male, Surgery, Sonographer, MESH : Arthritis, Rheumatoid, MESH : Reference Standards, MESH: Ultrasonography, Doppler, Joints, Nuclear medicine, business, MESH: Female
Abstract: Objective.To evaluate the intraobserver and interobserver reproducibility of B-mode and power Doppler (PD) sonography in patients with active long-standing rheumatoid arthritis (RA) comparatively with clinical data.Methods.In each of 7 patients being considered for a change in their RA treatment regimen, 7 healthcare professionals examined the 28 joints used in the Disease Activity Score 28-joint count (DAS28). Then 7 sonographers examined each of the 7 patients twice, using previously published B-mode and PD grading systems. The clinical reference standard was presence of synovitis according to at least 4/7 examiners. The sonographic reference standard was at least grade 1 (ALG1) or 2 (ALG2) synovitis according to at least 4/7 sonographers. Interobserver reproducibility of sonography was assessed versus the sonographer having the best intraobserver reproducibility. Agreement was measured by Cohen’s kappa statistic.Results.Intraobserver and interobserver reproducibility of B-mode and PD used separately was fair to good. Agreement between clinicians and sonographers at all sites using B-mode, PD, and both was 0.46, 0.37, and 0.36, respectively, for grade 1 synovitis; and 0.58, 0.19, and 0.19 for grade 2 synovitis. The number of joints with synovitis was smaller by physical examination (36.7%) than by B-mode with ALG1 (58.6%; p < 0.001). The number of joints with synovitis was higher by physical examination than by PD with both ALG1 (17.8%; p < 0.0001) and ALG2 (6.6%; p < 0.0001).Conclusion.PD findings explain most of the difference between clinical and sonographic joint assessments for synovitis in patients with long-standing RA.
Published: 2010
Full Text: View/download PDF

14. Articular manifestations in primary Sjögren's syndrome: clinical significance and prognosis of 188 patients

Author: Daniel Petit, Marie-Odile Jauberteau, Véronique Loustaud-Ratti, Eric Hachulla, Marc Lambert, Anne-Laure Fauchais, Kim Heang Ly, Holly Bezanahari, Bali Ouattara, Guillaume Gondran, Pierre-Yves Hatron, Elisabeth Vidal, Fabrice Lalloué, Eric Liozon, David Launay, Homéostasie Cellulaire et Pathologies (HCP), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Université de Limoges (UNILIM), Service de médecine interne, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Biologie moléculaire et cellulaire des microorganismes (EA3175), and Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Pathology, MESH: Antirheumatic Agents, MESH: Hydroxychloroquine, Systemic scleroderma, Gastroenterology, Etanercept, Cohort Studies, 0302 clinical medicine, Pharmacology (medical), 030212 general & internal medicine, MESH: Cohort Studies, MESH: Aged, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Middle Aged, Prognosis, Cryoglobulinemia, 3. Good health, MESH: Joints, Sjogren's Syndrome, MESH: Joint Diseases, Antirheumatic Agents, Cohort, Corticosteroid, Female, France, Joint Diseases, medicine.drug, Hydroxychloroquine, musculoskeletal diseases, Adult, medicine.medical_specialty, medicine.drug_class, MESH: Multivariate Analysis, MESH: Prognosis, 03 medical and health sciences, Rheumatology, Internal medicine, Synovitis, medicine, Humans, Clinical significance, Aged, 030203 arthritis & rheumatology, MESH: Humans, business.industry, MESH: Adult, medicine.disease, eye diseases, MESH: Male, MESH: France, stomatognathic diseases, Peripheral neuropathy, MESH: Sjogren's Syndrome, Multivariate Analysis, Joints, business, MESH: Female
Abstract: International audience; OBJECTIVES: Articular manifestations (AMs) occurred in approximately 30-60% of patients with primary SS (pSS). We conducted the current study to describe clinical presentation, specific treatment and to report clinical outcome of pSS patients with AM in a large bicentric French cohort. METHODS: Clinical, biological and immunological features of 419 consecutive patients with pSS were recorded in order to describe the clinical and immunological course of pSS AM and to point out the impact of those rheumatological features on pSS evolution. RESULTS: A total of 188 patients with pSS (172 women, 16 men) exhibited AM. They preceded sicca symptoms in 32, were simultaneous to pSS diagnosis in 98 and followed diagnosis in 59 patients. Clinical presentation was polyarticular and concerned mostly peripheral joints (synovitis, n = 66). Symptoms responded readily to symptomatic treatment in 45 cases (24%). DMARDs or immunosuppressive treatments were introduced in 133 patients: HCQ (n = 111), corticosteroid (n = 53), MTX (n = 12), SSZ (n = 6), AZA (n = 3), LEF (n = 1), etanercept (n = 1) and allochrysine (n = 1). Only one case of RA was diagnosed during the evolution. Statistical analysis identified clinical and biological factors associated with AM (P < or = 0.05): RP, muscular manifestations, renal involvement, peripheral neuropathy, cutaneous vasculitis, and positivity of RF, anti-SSB antibodies and cryoglobulinaemia. Patients with AM at diagnosis were characterized by a multisystemic involvement at the end of the follow-up period (P < 0.001). CONCLUSION: Although AMs are frequent and usually mild in pSS, these manifestations are associated with a pluri-systemic involvement of pSS.
Published: 2010
Full Text: View/download PDF

15. Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: Influence on disease activity score-28 values (SEA-repro study part I)

Author: Laurent Grange, Jean-David Albert, Christophe Hudry, Jérémie Sellam, F. Etchepare, Cécile Hacquard, Sandrine Jousse-Joulin, M.A. D'Agostino, Maxime Dougados, Thierry Marhadour, Alain Saraux, Philippe Gaudin, Gérard Chalès, Isabelle Chary Valckenaere, Jacques Bentin, Damien Loeuille, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service de rhumatologie [Rennes] = Rheumatology [Rennes], CHU Pontchaillou [Rennes], Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Rhumatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Physiopathologie, Pharmacologie et Ingénierie articulaires (PPIA), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Rhumatologie, CHU Brugmann, CHU Brugmann, Belgium, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie, Hôpital Sud, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Rhumatologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Ambroise Paré, Physiopathologie, Pharmacologie et Ingénierie articulaires ( PPIA ), Université Henri Poincaré - Nancy 1 ( UHP ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), and Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Subjects: Male, Settore MED/16 - REUMATOLOGIA, MESH: Synovitis, MESH : Aged, Arthritis, Severity of Illness Index, Arthritis, Rheumatoid, 0302 clinical medicine, Cohen's kappa, Rheumatoid, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Immunology and Allergy, MESH : Female, MESH : Joints, Ultrasonography, MESH : Synovitis, MESH: Aged, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, Synovitis, Disease activity score-28, Technician, Middle Aged, Reference Standards, Reproducibility, MESH: Reproducibility of Results, MESH: Joints, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH : Severity of Illness Index, MESH: Reference Standards, Female, musculoskeletal diseases, medicine.medical_specialty, MESH : Male, Immunology, Rheumatoid Arthritis, Disease activity, 03 medical and health sciences, Rheumatology, MESH: Severity of Illness Index, Severity of illness, medicine, Humans, MESH : Middle Aged, Joint swelling, Aged, 030203 arthritis & rheumatology, MESH: Humans, business.industry, MESH : Reproducibility of Results, MESH : Humans, Reproducibility of Results, medicine.disease, MESH: Male, MESH : Reference Standards, MESH : Arthritis, Rheumatoid, Physical therapy, Joints, business, MESH: Female, 030215 immunology
Abstract: Objectives.To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28).Methods.Seven healthcare professionals from different cities examined the same patients with active non-early rheumatoid arthritis (RA; duration > 4 yrs), for whom a treatment change was being considered. There was no training session and the examination was to be performed as quickly as possible. The healthcare professionals assessed the 28 joints of the DAS28 in 7 patients (196 joints), then reexamined the same 28 joints in 4 of these 7 patients (112 joints), who had been rendered unrecognizable. Then 7 sonographers examined each of the 7 patients twice, using B-mode and power Doppler ultrasound (PD). The reference standards were presence of synovitis according to at least 50% of clinical examiners and 50% of sonographers. Agreement was assessed by Cohen’s kappa statistic.Results.Intraobserver reliability ranged from 0.31 (least experienced research technician) to 0.77 (most experienced physician). Interobserver reliability ranged from 0.18 to 0.62. The largest difference between the lowest and the highest swollen joint counts in the same patient was 15, and the greatest variation in the DAS28 score was 0.92. Agreement between clinical and sonographic reference standards was 0.46, 0.37, and 0.36 for B-mode, PD, and both, respectively.Conclusion.Clinical inter- and intraobserver reliability is highly dependent on the examiner. Consequences on the DAS28 score can be substantial. Agreement with sonography is poor when both B-mode and PD are used but seems better, although low, when B-mode is used alone.
Published: 2010
Full Text: View/download PDF

16. The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

Author: Gabriel J. Tobón, Alain Saraux, Pierre Youinou, Michel, Geneviève, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Laboratoire d'Immunologie et Immunothérapie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), and CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato)
Subjects: MESH: Geography, Prevalence, Arthritis, Disease, Arthritis, Rheumatoid, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, MESH: Autoimmune Diseases, Epidemiology, Immunology and Allergy, MESH: Animals, MESH: Incidence, MESH: Protein Tyrosine Phosphatase, Non-Receptor Type 22, MESH: Developing Countries, MESH: HLA-DRB1 Chains, 0303 health sciences, education.field_of_study, MESH: Arthritis, Rheumatoid, Geography, Incidence (epidemiology), Incidence, Smoking, MESH: Genetic Predisposition to Disease, 3. Good health, Europe, MESH: Joints, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.medical_specialty, MESH: Smoking, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Population, MESH: Protein Tyrosine Phosphatases, Environment, Autoimmune Diseases, PTPN22, 03 medical and health sciences, Internal medicine, MESH: Polymorphism, Genetic, medicine, Animals, Humans, Genetic Predisposition to Disease, education, MESH: Environment, Developing Countries, MESH: Prevalence, 030304 developmental biology, 030203 arthritis & rheumatology, Autoimmune disease, Polymorphism, Genetic, MESH: Humans, business.industry, Protein Tyrosine Phosphatase, Non-Receptor Type 22, HLA-DR Antigens, medicine.disease, MESH: HLA-DR Antigens, MESH: North America, North America, Joints, MESH: Europe, Protein Tyrosine Phosphatases, business, HLA-DRB1 Chains
Abstract: International audience; Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by a distinctive pattern of bone and joint destruction. RA patients have an increased risk of death. The incidence and prevalence of RA vary across populations, statistical methods, and disease definitions. In North America and Northern Europe, the incidence of RA is estimated at 20 to 50 cases per 100,000 population and the prevalence at 0.5% to 1.1%. Lower incidences and prevalences have been reported in Southern Europe, and few data are available for developing countries. Some studies showed declining incidences and prevalences after the 1960s. RA is a multifactorial disease that results from interactions between genetic and environmental factors. The main genetic factors are HLA-DRB1 and the tyrosine-phosphatase gene PTPN22. Among environmental factors implicated in the development of RA, smoking shows the strongest association with RA susceptibility and is also linked to worse outcomes. The aim of this review is to discuss the available data on the incidence and prevalence of RA, as well as the genetic and environmental risk factors associated with RA.
Published: 2010

17. Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: Development of recommendations for clinical practice based on data from the literature and experts opinion

Author: Jacques Tebib, Xavier Le Loët, Thierry Schaeverbeke, Philippe Gaudin, Alain Saraux, Philippe Goupille, Carine Salliot, René Marc Flipo, Bernard Combe, Pascal Claudepierre, Daniel Wendling, Emmanuelle Dernis, Alain Cantagrel, Carle Paul, F. Lavie, Jean-Francis Maillefert, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Hôpital Lapeyronie [Montpellier] (CHU), Cambefort, Jeanne, Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Service de rhumatologie, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Service de Rhumatologie, Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de rhumatologie [CHU Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Service d'immunologie et rhumatologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Bordeaux [Bordeaux], Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Cochin [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Lariboisière - Université Paris Diderot - Paris 7 (UP7), Centre Hospitalier Universitaire de Dijon (CHU Dijon), Génétique, Immunothérapie, Chimie et Cancer (GICC), Université François Rabelais - Tours - Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Joseph Fourier - Grenoble 1 (UJF) - CHU Grenoble, CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin, Hôpital Lapeyronie, and Université Montpellier 1 (UM1) - Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Hôpital Lapeyronie
Subjects: MESH: Antirheumatic Agents, [SDV]Life Sciences [q-bio], Alternative medicine, Recommendations, Placebos, 0302 clinical medicine, MESH: Practice Guidelines as Topic, Azathioprine, MESH: Arthritis, Psoriatic, 030212 general & internal medicine, MESH: Advisory Committees, computer.programming_language, Randomized Controlled Trials as Topic, Evidence-Based Medicine, Anti-Inflammatory Agents, Non-Steroidal, MESH: Follow-Up Studies, MESH: Anti-Inflammatory Agents, Non-Steroidal, 3. Good health, Clinical Practice, [SDV] Life Sciences [q-bio], MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Psoriatic arthritis, Practice Guidelines as Topic, Leflunomide, MESH: Expert Testimony, medicine.medical_specialty, Advisory Committees, MEDLINE, MESH: Placebos, Pharmacological treatment, 03 medical and health sciences, Rheumatology, medicine, Humans, Hospitals, Teaching, Expert Testimony, Glucocorticoids, MESH: Azathioprine, 030203 arthritis & rheumatology, MESH: Humans, Spondylarthropathy, Task force, business.industry, Arthritis, Psoriatic, Everyday clinical practice, Isoxazoles, MESH: Hospitals, Teaching, medicine.disease, Sulfasalazine, Treatment, MESH: Randomized Controlled Trials as Topic, Methotrexate, MESH: Isoxazoles, Family medicine, Physical therapy, Joints, business, MESH: Glucocorticoids, computer, Delphi, Rheumatism, MESH: Evidence-Based Medicine, Follow-Up Studies
Abstract: International audience; Objectives: To develop recommendations about treatment (except anti-TNF agents) of psoriatic arthritis with peripheral joint involvement (PsA) seen in everyday practice, using evidence from the literature, supplemented with expert opinion when needed. Methods: The recommendations were based on evidence from the literature. First, a scientific committee used a Delphi procedure to select five focal points of interest. Then, a literature task force looked for relevant publications in the following: Cochrane, Pubmed, and Ovid databases and abstracts from the French Society for Rheumatology, European League against Rheumatism and American College of Rheumatology. Based on the data from these publications, recommendations were drafted and then validated by a group of 68 experts. The strength of each recommendation was determined, as well as the extent of agreement among the experts. Results: The evidence extracted from 73 selected papers was presented to experts during interactive workshops. At the end of the workshops, the experts drafted six recommendations, which were then validated by a final vote including all participants. These six recommendations displayed various strength from B to D. Conclusion: These recommendations should help to improve practice uniformity and, ultimately, to improve the management of PsA in France. (C) 2009 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
Published: 2009
Full Text: View/download PDF

18. Diagnosis of peripheral psoriatic arthritis: recommendations for clinical practice based on data from the literature and experts opinion

Author: Bernard Combe, Carine Salliot, Philippe-M. Goupille, Thierry Schaeverbeke, Alain Cantagrel, Daniel Wendling, J.-F. Maillefert, Emmanuelle Dernis, Pascal Claudepierre, Carle Paul, F. Lavie, Xavier Le Loët, Jacques Tebib, René-Marc Flipo, Alain Saraux, Philippe Gaudin, Service de rhumatologie, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Service de Rhumatologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de rhumatologie [CHU Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de rhumatologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Bordeaux [Bordeaux], Service d'immunologie et rhumatologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Département de Rhumatologie[Montpellier], and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie
Subjects: MESH: Expert Testimony, medicine.medical_specialty, Health Planning Guidelines, Alternative medicine, MEDLINE, Delphi method, Arthritis, Rheumatoid, Diagnosis, Differential, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Rheumatology, MESH: Practice Guidelines as Topic, MESH: Diagnosis, Differential, Internal medicine, MESH: Rheumatology, medicine, Humans, Psoriasis, MESH: Arthritis, Psoriatic, Spondylitis, Ankylosing, 030212 general & internal medicine, Expert Testimony, 030203 arthritis & rheumatology, MESH: Arthritis, Rheumatoid, MESH: Psoriasis, Evidence-Based Medicine, MESH: Humans, business.industry, Arthritis, Psoriatic, MESH: Biological Markers, medicine.disease, MESH: Spondylitis, Ankylosing, MESH: Health Planning Guidelines, 3. Good health, Clinical Practice, Radiography, MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Family medicine, Radiological weapon, Practice Guidelines as Topic, Physical therapy, Joints, business, Rheumatism, Biomarkers, MESH: Evidence-Based Medicine
Abstract: International audience; OBJECTIVE: To propose French recommendations for the clinical, biological and radiological diagnosis of peripheral psoriatic arthritis (PsA) in daily practice based on data from the literature and expert opinion. METHOD: The strategy was the following: the choice of four questions, concerning this topic by the scientific committee according to the Delphi method, forming the basis of the recommendations. The Systematic literature research based on Medline, Cochrane and abstracts from the annual meetings of the French society of rheumatology (SFR), American college of rheumatology (ACR) and European ligue against rheumatism (EULAR). An experts committee of rheumatologists elaborated, validated specifying the strength and the degree of agreement of each recommendation. RESULTS: The questions selected were: (1) What clinical data should be collected to assist in the diagnosis of psoriatic arthritis? (2) What laboratory tests, immunological tests, and genetic tests should be performed to assist in the diagnosis of psoriatic arthritis? (3) What are the radiological investigations useful in the diagnosis of psoriatic arthritis? (4) What classification and/or diagnosis criteria can assist in the diagnosis of psoriatic arthritis? A literature search identified 1627 abstracts and 33 articles were included and analyzed. Four recommendations relative to the diagnosis were drafted and validated by a final vote of the experts committee. CONCLUSION: Recommendations concerning the diagnosis of PsA for daily practice were developed and validated on the basis of data from the literature and expert opinion. They should help to establish the diagnosis of PsA in daily practice.
Published: 2009
Full Text: View/download PDF

19. Bone scintigraphy pattern of joint chronic graft-versus-host disease after allogeneic bone marrow transplantation

Author: Oleg Blagosklonov, Ingrid Biancheri, Frédéric Paycha, Michel Runge, C.-M. Ungureanu, Daniel Wendling, Hatem Boulahdour, O. Angoue, Réka Zsigmond, Fabrice Larosa, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de Médecine nucléaire, biophysique, isotopes [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Agents pathogènes et inflammation - UFC (EA 4266) (API)
Subjects: Adult, Male, medicine.medical_specialty, Graft vs Host Disease, MESH: Graft vs Host Disease, Bone and Bones, 03 medical and health sciences, 0302 clinical medicine, Text mining, medicine, MESH: Transplantation, Homologous, Humans, Transplantation, Homologous, Radiology, Nuclear Medicine and imaging, Autogenous bone, Radionuclide Imaging, MESH: Bone Marrow Transplantation, ComputingMilieux_MISCELLANEOUS, Bone Marrow Transplantation, MESH: Humans, medicine.diagnostic_test, business.industry, Marrow transplantation, MESH: Chronic Disease, MESH: Adult, General Medicine, MESH: Bone and Bones, medicine.disease, MESH: Male, 3. Good health, Surgery, MESH: Joints, Graft-versus-host disease, Bone scintigraphy, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 030220 oncology & carcinogenesis, Chronic Disease, Joints, business, 030215 immunology
Abstract: International audience
Published: 2009
Full Text: View/download PDF

20. The Inactivation Principle: Mathematical Solutions Minimizing the Absolute Work and Biological Implications for the Planning of Arm Movements

Author: Frédéric Jean, Bastien Berret, Thierry Pozzo, Jean-Paul Gauthier, Charalambos Papaxanthis, Christian Darlot, Autard, Delphine, Motricité - Plasticité, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Nationale Supérieure des Télécommunications (ENST), École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Istituto Italiano di Tecnologia (IIT), Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), This work is in part supported by the Centre National d'Etudes Spatiales and the Conseil Régional de Bourgogne, Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Ecole Nationale Supérieure des Télécommmunications [Paris] ( ENST Paris ), ENST Paris, École Nationale Supérieure de Techniques Avancées ( Univ. Paris-Saclay, ENSTA ParisTech ), Istituto Italiano di Tecnologia ( IIT ), Laboratoire des Sciences de l'Information et des Systèmes ( LSIS ), and Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Male, MESH: Range of Motion, Articular, MESH : Physical Exertion, MESH : Movement, Optimality criterion, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Computer science, MESH: Muscle Contraction, MESH: Gravitation, MESH : Models, Biological, MESH: Movement, Kinematics, MESH: Postural Balance, MESH : Gravitation, 0302 clinical medicine, Neuroscience/Motor Systems, MESH : Feedback, MESH : Biomechanics, Range of Motion, Articular, MESH: Arm, MESH : Joints, lcsh:QH301-705.5, Postural Balance, MESH: Biomechanics, 0303 health sciences, Neuroscience/Behavioral Neuroscience, Ecology, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Feedback, MESH : Adult, Biomechanical Phenomena, Mathematical theory, MESH: Joints, Computational Theory and Mathematics, Modeling and Simulation, Arm, Research Article, Gravitation, Muscle Contraction, Computer Science/Systems and Control Theory, Adult, MESH : Male, Movement, Physical Exertion, Computational Biology/Computational Neuroscience, MESH: Psychomotor Performance, Models, Biological, MESH : Arm, Feedback, MESH: Physical Exertion, 03 medical and health sciences, Cellular and Molecular Neuroscience, MESH : Postural Balance, Control theory, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Genetics, Humans, Neuroscience/Theoretical Neuroscience, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Simulation, 030304 developmental biology, MESH: Humans, MESH : Humans, Work (physics), MESH: Models, Biological, Motor control, MESH: Adult, MESH : Psychomotor Performance, Function (mathematics), Optimal control, MESH: Male, Term (time), MESH : Range of Motion, Articular, lcsh:Biology (General), MESH : Muscle Contraction, Joints, 030217 neurology & neurosurgery, Mathematics, Psychomotor Performance
Abstract: An important question in the literature focusing on motor control is to determine which laws drive biological limb movements. This question has prompted numerous investigations analyzing arm movements in both humans and monkeys. Many theories assume that among all possible movements the one actually performed satisfies an optimality criterion. In the framework of optimal control theory, a first approach is to choose a cost function and test whether the proposed model fits with experimental data. A second approach (generally considered as the more difficult) is to infer the cost function from behavioral data. The cost proposed here includes a term called the absolute work of forces, reflecting the mechanical energy expenditure. Contrary to most investigations studying optimality principles of arm movements, this model has the particularity of using a cost function that is not smooth. First, a mathematical theory related to both direct and inverse optimal control approaches is presented. The first theoretical result is the Inactivation Principle, according to which minimizing a term similar to the absolute work implies simultaneous inactivation of agonistic and antagonistic muscles acting on a single joint, near the time of peak velocity. The second theoretical result is that, conversely, the presence of non-smoothness in the cost function is a necessary condition for the existence of such inactivation. Second, during an experimental study, participants were asked to perform fast vertical arm movements with one, two, and three degrees of freedom. Observed trajectories, velocity profiles, and final postures were accurately simulated by the model. In accordance, electromyographic signals showed brief simultaneous inactivation of opposing muscles during movements. Thus, assuming that human movements are optimal with respect to a certain integral cost, the minimization of an absolute-work-like cost is supported by experimental observations. Such types of optimality criteria may be applied to a large range of biological movements., Author Summary When performing reaching and grasping movements, the brain has to choose one trajectory among an infinite set of possibilities. Nevertheless, because human and animal movements provide highly stereotyped features, motor strategies used by the brain were assumed to be optimal according to certain optimality criteria. In this study, we propose a theoretical model for motor planning of arm movements that minimizes a compromise between the absolute work exerted by the muscles and the integral of the squared acceleration. We demonstrate that under these assumptions agonistic and antagonistic muscles are inactivated during overlapping periods of time for quick enough movements. Moreover, it is shown that only this type of criterion can predict these inactivation periods. Finally, experimental evidence is in agreement with the predictions of the model. Indeed, we report the existence of simultaneous inactivation of opposing muscles during fast vertical arm movements. Therefore, this study suggests that biological movements partly optimize the energy expenditure, integrating both inertial and gravitational forces during the motor planning process.
Published: 2008
Full Text: View/download PDF

21. Pathophysiological links between rheumatoid arthritis and the Epstein-Barr virus: an update

Author: Eric Toussirot, Jean Roudier, Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Immunogenetique de la Polyarthrite Rhumatoide, and Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Epstein-Barr Virus Infections, Herpesvirus 4, Human, Arthritis, Autoimmunity, medicine.disease_cause, Peripheral blood mononuclear cell, Virus, MESH: Immunity, Cellular, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Antigen, hemic and lymphatic diseases, MESH: Autoimmunity, medicine, Humans, Antigens, Viral, 030304 developmental biology, 030203 arthritis & rheumatology, 0303 health sciences, Immunity, Cellular, MESH: Arthritis, Rheumatoid, MESH: Humans, biology, MESH: Epstein-Barr Virus Infections, business.industry, Citrullination, MESH: Herpesvirus 4, Human, medicine.disease, Epstein–Barr virus, MESH: Antibody Formation, 3. Good health, MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Immunology, Antibody Formation, biology.protein, Joints, Antibody, business, MESH: Antigens, Viral
Abstract: International audience; Numerous associations have been documented between the Epstein-Barr virus (EBV) and rheumatoid arthritis (RA). Thus, anti-EBV antibody titers are higher in RA patients than in healthy controls. Lymphocytes from RA patients show impaired responses to EBV. Several EBV antigens share similarities with self antigens; more specifically, the glycine/alanine repeats in EBNA-1 resemble synovial proteins and the EBV gp110 glycoprotein contains a copy of the shared epitope. Cell-mediated responses to EBV replicative cycle proteins and to gp110 have been documented in joint fluid from RA patients. In situ hybridization and PCR techniques have identified EBV antigens and genetic material within the rheumatoid synovium, albeit with variable yields. The EBV burden in peripheral blood mononuclear cells is higher in RA patients than in controls. EBNA-1 can undergo citrullination, and the EBV can induce antibodies to citrullinated peptides. RA patients are at increased risk for lymphoma, including EBV-associated lymphoma. Despite these multiple and complex links between EBV and RA, proof of a causal association is lacking. EBV infection may contribute indirectly to the pathophysiology of RA by impairing immune control of EBV replication, causing increased exposure to EBV antigens and, thereby, chronic inflammation. The effect of biotherapies for RA on EBV-host relations needs to be investigated.
Published: 2007
Full Text: View/download PDF

22. Inflammatory and structural evaluation in spondyloarthritis: magnetic resonance imaging analysis of axial and peripheral involvement

Author: Hoenen-Clavert, Virginie, Rat, Anne Christine, Loeuille, Damien, Bettembourg-Brault, Isabelle, Michel-Batot, Christine, Alain Blum, Pourel, Jacques, Chary-Valckenaere, Isabelle, Rat, Anne-Christine, Service de Rhumatologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Physiopathologie, Pharmacologie et Ingénierie articulaires (PPIA), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Département de Radiologie adultes [CHRU Nancy], and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL)
Subjects: Male, MESH: Synovitis, education, MESH: Ligaments, MESH: Tenosynovitis, MESH: Pain Measurement, MESH: Observer Variation, Sensitivity and Specificity, Severity of Illness Index, MESH: Magnetic Resonance Imaging, MESH: Severity of Illness Index, Image Interpretation, Computer-Assisted, Humans, Single-Blind Method, Osteitis, Pain Measurement, Observer Variation, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Humans, Ligaments, Synovitis, Tenosynovitis, MESH: Single-Blind Method, equipment and supplies, Magnetic Resonance Imaging, MESH: Male, MESH: Sensitivity and Specificity, MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Osteitis, Spondylarthropathies, Female, Joints, MESH: Female, MESH: Image Interpretation, Computer-Assisted, human activities, MESH: Spondylarthropathies
Abstract: To determine the magnetic resonance imaging (MRI) criteria of most value in the assessment of patients with spondyloarthropathy (SpA) with axial or peripheral involvement.Fat suppressed (FS)-T2 and pre- and postinjection FS-T1 images were obtained in the most symptomatic region (axial or peripheral) of patients requiring tumor necrosis factor-a blockers. Thirty-eight MRI (21 axial and 17 peripheral) were blindly scored at synovial (S) and entheseal (E) sites by 2 experienced observers screening for 7 inflammatory and 7 structural predefined criteria, which were evaluated for frequency (N) and intra- and interobserver reproducibility.In peripheral regions, synovitis (S; N = 69.4%), ligament inflammation (E; N = 39.7%), bone marrow edema (S; N = 22.1%; E; N = 15%), and tenosynovitis (S; N = 21%) were recorded with good to excellent intraobserver reproducibility [intraclass correlation coefficient (ICC) 0.49-0.93] and moderate to good interobserver reproducibility (ICC 0.49-0.66). With regard to structural criteria, erosions (S; N = 17.1%) and enthesophytes (E; N = 13.9%) exhibited good to excellent intraobserver (ICC 0.71-0.85) and moderate interobserver reproducibility (ICC 0.54-0.49); the reproducibility of fat inflation (N = 1.4%) was good (ICC 0.76-0.78). In axial regions, no inflammatory criteria achieved good interobserver reproducibility. However, fat inflation (S; N = 86%), chondral lesions (S; N = 85.8%), enthesophytes (E; N = 76.7%), fusion (S; N = 41.2%), and erosions (S; N = 25.1%) showed excellent intraobserver reproducibility (ICC 0.81-0.98), and moderate to excellent interobserver reproducibility (ICC 0.50-0.96).In terms of intra- and interobserver reproducibility, MRI is a reliable tool with which to assess synovitis, bone edema, ligament inflammation, tenosynovitis, erosion, enthesophytes, and fat inflation in patients with peripheral involvement. In those with axial involvement, inflammatory criteria lack interobserver reproducibility, but chondral lesions, erosion, fat inflation, fusion, and enthesophytes are relevant.
Published: 2007

23. A support method for the contextual interpretation of biomechanical data

Author: Anne-Pascale Godillon-Maquinghen, Stéphane Bouilland, Denis Bouttens, Emmanuel Roux, Patrice Caulier, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Centre Jacques Calvé, Fondation Hopale, Institut Calot, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Databases, Factual, Computer science, fuzzy rules, 02 engineering and technology, MESH: Movement, computer.software_genre, Field (computer science), objective explanation, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], 0302 clinical medicine, Functional evaluation, 0202 electrical engineering, electronic engineering, information engineering, MESH: Animals, MESH: Biomechanics, Fuzzy rule, General Medicine, stratiﬁed tenfold cross validations, Computer Science Applications, Temporal database, Biomechanical Phenomena, MESH: Joints, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 020201 artificial intelligence & image processing, Data mining, MESH: Fuzzy Logic, Algorithms, Biotechnology, fuzzy decision trees, Movement, Fuzzy set, Decision tree, MESH: Algorithms, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Machine learning, Fuzzy logic, Models, Biological, Cross-validation, Upper Extremity, 03 medical and health sciences, Knowledge-based systems, MESH: Computer Simulation, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Fuzzy Logic, Artificial Intelligence, MESH: Artificial Intelligence, Animals, Humans, Computer Simulation, Electrical and Electronic Engineering, MESH: Humans, business.industry, three-dimensional (3-D)-movement measurement, MESH: Models, Biological, MESH: Upper Extremity, MESH: Databases, Factual, Joints, Artificial intelligence, business, computer, 030217 neurology & neurosurgery
Abstract: International audience; In the clinical field, biomechanical data provided by advanced technical devices are still underexploited. Data analysis usually consists of extracting attributes or computing synthetic values from temporal data and exploiting them by means of a monovariable statistical method. This article proposes a method to support clinicians, especially those in orthopedics, in the contextual interpretation of biomechanical data. We propose to characterize temporal biomechanical data by means of fuzzy space-time windows and to induce fuzzy decision trees to map the biomechanical and clinical data related to patients. Then, we present a method for objectively explaining a given clinical characteristic of a particular patient; this method is derived using the fuzzy rule base generated from the trees and a satisfiability measure. We have applied our method to real data in order to provide an objective explanation of the subjective self-evaluation of the functional status of patients with a shoulder prosthesis, and evaluate it by means of the stratified tenfold cross validation method. The mean explanation rate--which corresponds to the mean proportion of the patients belonging to test sets whose functional state is explained by the proposed method--exceeds 80% for more than half of the decision trees, and exceeds 70% for 94% of the trees. By supporting clinicians during the biomechanical data interpretation process, our method helps them take the objective biomechanical measurements in the medical practice into account, particularly in orthopedics. It can also make subjective evaluations more objective by mapping subjective and objective data.
Published: 2006
Full Text: View/download PDF

24. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA‐DR shared epitope and severity of bone destruction

Author: Hubert Marotte, Bruno Mougin, Pierre Farge, Pierre Miossec, Christian Alexandre, Philippe Gaudin, Service d'immunologie et rhumatologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Groupe de Recherche et d'Etude du Processus Inflammatoire (GREPI), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Contraintes mécaniques et tissu osseux, and Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Pathology, Alveolar Bone Loss, Arthritis, MESH: Logistic Models, Mandible, Salivary Glands, Arthritis, Rheumatoid, Epitopes, 0302 clinical medicine, Immunopathology, MESH: Reverse Transcriptase Polymerase Chain Reaction, Immunology and Allergy, MESH: Aged, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, MESH: Polymorphism, Single Nucleotide, MESH: Bone and Bones, Middle Aged, Connective tissue disease, Extended Report, MESH: Joints, Sjogren's Syndrome, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, medicine.medical_specialty, MESH: Salivary Glands, MESH: Epitopes, Immunology, MESH: Carpal Bones, MESH: Mandible, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Bone and Bones, 03 medical and health sciences, Rheumatology, Internal medicine, Sicca syndrome, Biopsy, medicine, Humans, Carpal Bones, Aged, 030203 arthritis & rheumatology, MESH: Epitope Mapping, MESH: Humans, business.industry, Tumor Necrosis Factor-alpha, MESH: Interleukin-1, 030206 dentistry, Odds ratio, HLA-DR Antigens, medicine.disease, MESH: HLA-DR Antigens, MESH: Alveolar Bone Loss, MESH: Male, MESH: Sjogren's Syndrome, Logistic Models, MESH: Tumor Necrosis Factor-alpha, Joints, business, MESH: Female, Epitope Mapping, Interleukin-1
Abstract: International audience; OBJECTIVE: To evaluate a possible association between wrist and periodontal destruction in rheumatoid arthritis, and between periodontal destruction, dry mouth, and labial salivary gland biopsy and the contribution of genetic factors (the shared epitope (SE) and IL1B (+3954) or TNFA (-238 or -308) gene polymorphisms). METHODS: 147 patients with rheumatoid arthritis were enrolled. Periodontal damage was defined according to the Hugoson and Jordan criteria on panoramic dental x rays. Typing for the SE and cytokine polymorphisms was undertaken by enzyme linked oligosorbent assay. Odds ratios (OR), relative risk (RR), and chi2 values were calculated to quantify associations. RESULTS: An association was observed between wrist and periodontal bone destruction (chi2=11.82; p
Published: 2005
Full Text: View/download PDF

25. Motor compensation and recovery for reaching in stroke patients

Author: Roby-Brami, Agnès, Feydy, A., Combeaud, M., Biryukova, E. V., Bussel, B., Levin, M. F., Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Department of Neurological Rehabilitation, Hôpital Raymond Poincaré [AP-HP], Plasticité cérébrale et adaptations des fonctions visuelles et motrices, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Higher Nervous Activity, Russian Academy of Sciences [Moscow] (RAS), School of rehabilitation, Rehabilitation Institute of Montreal, AP-HP Hôpital Raymond Poincaré [Garches], Neurophysique et physiologie du système moteur ( NPSM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Russian Academy of Sciences [Moscow] ( RAS ), and Lamotte D'Incamps, Boris
Subjects: Adult, Male, MESH : Case-Control Studies, MESH : Movement, MESH : Male, Movement, Posture, MESH : Aged, MESH: Movement, MESH: Psychomotor Performance, Motor Activity, MESH: Cerebrovascular Accident, MESH : Biomechanics, Humans, MESH : Middle Aged, MESH : Female, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Longitudinal Studies, MESH: Longitudinal Studies, MESH : Joints, MESH: Biomechanics, Aged, MESH : Longitudinal Studies, MESH: Aged, MESH: Middle Aged, MESH: Humans, MESH : Humans, MESH : Posture, Stroke Rehabilitation, MESH: Adult, MESH: Posture, MESH : Psychomotor Performance, MESH : Adult, Middle Aged, MESH: Case-Control Studies, MESH: Motor Activity, MESH: Male, Biomechanical Phenomena, Stroke, MESH: Joints, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Case-Control Studies, Female, Joints, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH : Cerebrovascular Accident, MESH : Motor Activity, MESH: Female, Psychomotor Performance
Abstract: OBJECTIVES: To examine the mechanisms of alternative strategies developed by stroke patients to compensate their motor impairment and their role in recovery. MATERIAL AND METHODS: The three-dimensional kinematics of the upper limb were quantified during unconstrained reaching movements in seven healthy individuals and in 15 stroke patients. Nine patients were followed-up. Individual observations were correlated with anatomical and functional brain imaging described elsewhere (Feydy et al. Stroke 2002;33:1610). RESULTS: Healthy subjects used mainly elbow extension and shoulder flexion, scaled to movement distance. Patients with hemiparesis because of stroke used different patterns of joint recruitment with different scaling rules. Patients with the greatest impairment compensated by recruiting extra degrees of freedom, particularly trunk bending. Improvement was because of a restoration towards a normal movement pattern (recovery) and/or to a reinforcement of compensation, which led to a poorer outcome. CONCLUSION: Individual behavioural data are necessary to discuss the mechanisms of functional improvement following stroke with respect to recovery and/or compensation.
Published: 2003

26. Hand orientation for grasping and arm joint rotation patterns in healthy subjects and hemiparetic stroke patients

Author: Nezha Bennis, Stéphane Jacobs, Agnès Roby-Brami, Mindy F. Levin, Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Department of Neurological Rehabilitation, Hôpital Raymond Poincaré [AP-HP], School of rehabilitation, Rehabilitation Institute of Montreal, Lamotte D'Incamps, Boris, AP-HP Hôpital Raymond Poincaré [Garches], Neurophysique et physiologie du système moteur ( NPSM ), and Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS )
Subjects: Male, Elbow, MESH : Aged, Wrist, Rotation, MESH : Rotation, MESH : Paresis, 0302 clinical medicine, MESH: Rotation, Orientation (geometry), MESH: Cerebrovascular Accident, MESH : Biomechanics, MESH : Female, MESH: Arm, MESH : Joints, MESH: Biomechanics, MESH: Aged, MESH: Middle Aged, Hand Strength, General Neuroscience, 05 social sciences, MESH : Hand, Middle Aged, MESH : Adult, Biomechanical Phenomena, Paresis, Stroke, MESH: Joints, medicine.anatomical_structure, MESH: Hand Strength, MESH : Brain Damage, Chronic, Arm, Brain Damage, Chronic, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, MESH : Hand Strength, MESH : Orientation, Adult, medicine.medical_specialty, MESH : Male, MESH: Orientation, 050105 experimental psychology, MESH : Arm, MESH: Hand, 03 medical and health sciences, MESH: Paresis, Physical medicine and rehabilitation, Orientation, Motor system, medicine, Humans, 0501 psychology and cognitive sciences, MESH : Middle Aged, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Molecular Biology, Aged, MESH: Humans, business.industry, MESH : Humans, MESH: Adult, Hand, Horizontal plane, MESH: Male, Hemiparesis, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Physical therapy, Joints, Shoulder joint, Neurology (clinical), MESH: Brain Damage, Chronic, business, MESH : Cerebrovascular Accident, MESH: Female, 030217 neurology & neurosurgery, Developmental Biology
Abstract: We previously demonstrated that the hand orientation for grasping (azimuth) is strongly coupled to arm movement direction in the horizontal plane. The question is whether this coupling is directly controlled or secondary to a regulation of the arm angular configuration. To this purpose, we quantified hand orientation and arm joint rotations during unconstrained reaching movements in healthy subjects and in patients with hemiparesis due to stroke since they use altered joint rotation patterns for reaching. Seven healthy subjects and eight patients with a right hemiparesis participated (four had a moderate and four had a mild disorder). Four electromagnetic sensors were used to measure hand orientation and to compute the wrist, elbow and shoulder joint angles. Hand azimuth at the time of grasping was correlated to arm movement direction in all the healthy and hemiparetic individuals. In healthy subjects, a regression analysis of the arm joint rotations suggested that the coupling between hand azimuth and movement direction was not due to a correlation with a particular degree of freedom. Patients used different hand orientations for grasping and different joint rotation patterns that varied according to their level of disability and the use of compensatory strategies. The findings observed in both healthy subjects and patients with stroke show that the coupling of hand azimuth for grasping to movement direction was controlled independently of the set of joint rotations used for reaching. This suggests that it is a basic synergy directly controlled by the motor system.
Published: 2003

27. Positive proprioceptive feedback elicited by isometric contractions of ankle flexors on pretibial motoneurons in cats

Author: Lena H. Ting, Daniel Zytnicki, L. Brizzi, Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), and Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS)
Subjects: MESH: Proprioception, Physiology, Stimulation, Isometric exercise, Membrane Potentials, MESH: Spinal Cord, 0302 clinical medicine, Medicine, Anesthesia, MESH: Animals, MESH: Isometric Contraction, Decerebrate State, Motor Neurons, Nerve Endings, 0303 health sciences, MESH: Muscle, Skeletal, MESH: Electrophysiology, MESH: Feedback, General Neuroscience, MESH: Neurons, Afferent, MESH: Electric Stimulation, musculoskeletal system, Electrophysiology, MESH: Joints, medicine.anatomical_structure, MESH: Nerve Endings, Spinal Cord, Excitatory postsynaptic potential, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Cats, MESH: Motor Neurons, MESH: Paralysis, In Vitro Techniques, MESH: Anesthesia, Feedback, 03 medical and health sciences, Isometric Contraction, Animals, Paralysis, MESH: Membrane Potentials, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurons, Afferent, MESH: Excitatory Postsynaptic Potentials, Muscle, Skeletal, Muscle Spindles, 030304 developmental biology, Positive feedback, Communication, Proprioception, business.industry, Excitatory Postsynaptic Potentials, Electric Stimulation, MESH: Decerebrate State, Reflex, Cats, Joints, Ankle, business, MESH: Muscle Spindles, Neuroscience, 030217 neurology & neurosurgery
Abstract: Pretibial flexor motoneurons were recorded intracellularly in anesthetized cats during unfused isometric contractions of a subpopulation of motor units from either tibialis anterior (TA) or extensor digitorum longus (EDL) muscles. The contractions elicited excitatory postsynaptic potentials in 23 of 28 pretibial flexor motoneurons. No effect was observed in the remaining motoneurons. In control experiments, the effects of electrical stimulation of afferents within the TA nerve were investigated to help identify afferents responsible for the contraction-induced positive feedback. This feedback was ascribed to actions of Ia fibers because the pattern of the contraction-induced excitatory potentials was consistent with the known pattern of Ia discharge; in control experiments, electrical stimulation of group I fibers elicited only monosynaptic excitatory potentials; and the distribution of both the contraction-induced positive feedback among motor nuclei as well as the electrically evoked Ia excitatory monosynaptic potentials were restricted to homonymous and synergic motoneurons. Observation of the Ia contraction-induced positive feedback was facilitated by the absence of Ib autogenic inhibition. This contraction-induced Ia excitatory feedback in ankle flexors might either reinforce Ia-induced reflexes when these muscles are lengthened or help to lift the leg over an obstacle.
Published: 2002
Full Text: View/download PDF

28. Development of a disease activity index for the assessment of reactive arthritis (DAREA)

Author: Gérard Eberl, H Hitzelhammer, Josef S. Smolen, F Gschnait, A Studnicka-Benke, Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, and Hugot, Bérengère
Subjects: Male, Index (economics), MESH: Pain Measurement, Test validity, Severity of Illness Index, 0302 clinical medicine, Medicine, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Pain Measurement, MESH: Treatment Outcome, MESH: Aged, MESH: Middle Aged, Bacterial Infections, Middle Aged, Anti-Bacterial Agents, MESH: Reproducibility of Results, MESH: Joints, C-Reactive Protein, Treatment Outcome, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Adult, medicine.medical_specialty, Composite score, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Bacterial Infections, Validation test, Arthritis, Reactive, Disease activity, 03 medical and health sciences, MESH: Cross-Sectional Studies, Rheumatology, MESH: Severity of Illness Index, MESH: Anti-Bacterial Agents, Prohibitins, MESH: C-Reactive Protein, Humans, In patient, Reactive arthritis, Aged, 030203 arthritis & rheumatology, Measurement method, MESH: Humans, business.industry, MESH: Arthritis, Reactive, Reproducibility of Results, MESH: Adult, medicine.disease, MESH: Male, MESH: Prospective Studies, Cross-Sectional Studies, Physical therapy, Joints, business, MESH: Female
Abstract: The objectives of this study were to investigate and validate individual variables and to develop a composite score for disease activity measurement in patients with reactive arthritis (REA)., In the first cross-sectional part, the clinical and laboratory evaluation of 45 patients was used to elaborate the most important individual disease activity measures. In the second prospective part, these variables as well as a composite score for disease activity measurement of REA were prospectively validated in 23 patients at two points in time., The following variables emerged as the most useful for the composite measure: number of swollen and tender joints, patient's pain and global assessment, and C-reactive protein. The score was calculated by simple addition of the individual figures., DAREA constitutes a reliable score which can easily be assessed on a day-to-day office work basis.
Published: 2000

29. Contribution of ankle, knee, and hip joints to the perception threshold for support surface rotation

Author: Pierre-Alain Barraud, Christian Raphel, Christophe Bourdin, Vincent Nougier, Didier Poquin, Normand Teasdale, Bettina Debû, Laboratoire Sport et Performance Motrice (EA 597), Université Joseph Fourier - Grenoble 1 (UJF), Centre de Recherches du Service de Santé des Armées (CRSSA), Service de Santé des Armées, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Palluel, Estelle
Subjects: Male, MESH: Proprioception, Motion Perception, Rotation, MESH: Differential Threshold, 0302 clinical medicine, MESH: Rotation, MESH: Time and Motion Studies, Psychophysics, Gravity Sensing, General Psychology, media_common, Mathematics, 05 social sciences, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH: Posture, Sensory Systems, MESH: Leg, MESH: Joints, medicine.anatomical_structure, MESH: Motion Perception, Time and Motion Studies, Female, Support surface, MESH: Neck, Adult, musculoskeletal diseases, medicine.medical_specialty, media_common.quotation_subject, Posture, MESH: Gravity Perception, Differential Threshold, MESH: Orientation, Experimental and Cognitive Psychology, 050105 experimental psychology, 03 medical and health sciences, Physical medicine and rehabilitation, Orientation, Perception, MESH: Analysis of Variance, medicine, Humans, 0501 psychology and cognitive sciences, Sensory cue, Joint (geology), Analysis of Variance, Leg, MESH: Humans, Proprioception, MESH: Adult, MESH: Male, Joints, Ankle, MESH: Female, Neck, 030217 neurology & neurosurgery, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Abstract: The purpose of the present experiment was to investigate the extent to which subjects can perceive, at very slow velocities, an angular rotation of the support surface about the medio-lateral axis of the ankle, knee, hip, or neck joint when visual cues are not available. Subjects were passively displaced on a slowly rotating platform at .01, .03, and .05 deg/sec. The subjects' task was to detect movements of the platform in four different postural conditions allowing body oscillations about the ankle, knee, hip, or neck joint. In Experiment 1, subjects had to detect backward and forward rotation (pitching). In Experiment 2, they had to detect left and right rotations of the platform (rolling). In Experiment 3, subjects had to detect both backward/forward and left/right rotations of the platform, with the body fixed and the head either fixed or free to move. Overall, when the body was free to oscillate about the ankle, knee, or hip joints, a similar threshold for movement perception was observed. This threshold was lower for rolling than for pitching. Interestingly, in these postural conditions, an unconscious compensation in the direction opposite to the platform rotation was observed on most trials. The threshold for movement perception was much higher when the head was the only segment free to oscillate about the neck joint. These results suggest that, in static conditions, the otoliths are poor detectors of the direction of gravity forces. They also suggest that accurate perception of body orientation is improved when proprioceptive information can be dynamically integrated.
Published: 1999

30. Control of single-joint movements in deafferented patients: evidence for amplitude coding rather than position control

Author: Michelle Fleury, Yves Lamarre, Jonathan Cole, Vincent Nougier, Normand Teasdale, Jacques Paillard, Chantal Bard, Robert Forget, Laboratoire Sport et Performance Motrice (EA 597), Université Joseph Fourier - Grenoble 1 (UJF), and Palluel, Estelle
Subjects: Adult, medicine.medical_specialty, MESH: Proprioception, Movement, Spatial Behavior, Sensory system, Motor program, MESH: Movement, Wrist, 050105 experimental psychology, MESH: Electromyography, MESH: Afferent Pathways, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Forearm, MESH: Spatial Behavior, Conditioning, Psychological, medicine, Humans, 0501 psychology and cognitive sciences, MESH: Denervation, Afferent Pathways, MESH: Humans, Proprioception, Electromyography, Pulse (signal processing), business.industry, General Neuroscience, 05 social sciences, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH: Adult, Body movement, MESH: Conditioning (Psychology), Denervation, Surgery, MESH: Joints, medicine.anatomical_structure, Upper limb, Joints, business, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 030217 neurology & neurosurgery
Abstract: Two deafferented patients and several control subjects participated in a series of experiments to investigate how accurate single-joint movements are programmed, spatially calibrated, and updated in the absence of proprioceptive information. The deafferented patients suffered from a permanent and severe loss of large sensory myelinated fibers below the neck. Subjects performed, with and without vision, sequences of forearm supinations and pronations with two temporal delays between each movement (0 s and 8 s). Overall, the lack of proprioception did not yield any significant decrease in movement accuracy when vision was available. Without vision, the absence of proprioceptive afferents yielded (1) significantly larger spatial errors, (2) amplitude errors similar to those of control subjects, and (3) a significant drift when an 8-s delay was introduced between two successive movements. Subjects also performed, without vision, a 20 degrees supination followed by a 20 degrees pronation that brought back the wrist to the starting position. On some trials, the supination was blocked unexpectedly by way of a magnetic brake. When the supination was blocked, subjects were already on the second target and no pronation was required when the brake was released. The deafferented patients, unaware of the procedure, always produced a 20 degrees pronation. These data confirm that deafferented patients were not coding a final position. It rather suggests that they coded an amplitude and translated the spatial distance between the two targets in a corresponding force pulse. Overall, the results highlight the powerful and key role of proprioceptive afferents for calibrating the spatial motor frame of reference.
Published: 1996
Full Text: View/download PDF

31. High-resolution magnetic resonance imaging of knee inflammatory arthritis in mice

Author: Saidenberg-Kermanac H N, Leclercq F, Herscovici J, Scherman D, Marie-Christophe Boissier, Unité de Pharmacologie Chimique et Génétique (UPCG - UMR_S 640/UMR 8151), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Paris Descartes - Paris 5 (UPD5) - Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM) - Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP) - Centre National de la Recherche Scientifique (CNRS) - Institut de Recherche pour le Développement (IRD) - Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP) - Centre National de la Recherche Scientifique (CNRS) - Institut de Recherche pour le Développement (IRD) - Université Paris Descartes - Paris 5 (UPD5), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Génétique, Pharmacologie Chimique Et
Subjects: MESH: Arthritis, Experimental, MESH: Mice, Inbred DBA, MESH: Stifle, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Arthritis, Experimental, Magnetic Resonance Imaging, Stifle, MESH: Magnetic Resonance Imaging, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Mice, MESH: Joints, Mice, Inbred DBA, Animals, Joints, MESH: Animals, MESH: Mice, ComputingMilieux_MISCELLANEOUS
Abstract: International audience

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources

Refine your results

31 results on '"MESH: Joints"'

1. Deriving stratified effects from joint models investigating Gene-Environment Interactions

2. Prognosis and follow-up of psoriatic arthritis with peripheral joint involvement: Development of recommendations for clinical practice based on published evidence and expert opinion

3. Computational Motor Control: Redundancy and Invariance

4. Respective interest of T2 mapping and diffusion tensor imaging in assessing porcine knee cartilage with MR at 3 Teslas

5. The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound

6. Can remission in rheumatoid arthritis be assessed without laboratory tests or a formal joint count? possible remission criteria based on a self-report RAPID3 score and careful joint examination in the ESPOIR cohort

7. Improving agreement in assessment of synovitis in rheumatoid arthritis

8. EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria

9. Effect of adherence to European treatment recommendations on early arthritis outcome: data from the ESPOIR cohort

10. Prediction of radiographic damage in early arthritis by sonographic erosions and power Doppler signal: a longitudinal observational study

11. Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

12. Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis

13. Reproducibility of joint swelling assessment by sonography in patients with long-lasting rheumatoid arthritis (SEA-Repro study part II)

14. Articular manifestations in primary Sjögren's syndrome: clinical significance and prognosis of 188 patients

15. Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: Influence on disease activity score-28 values (SEA-repro study part I)

16. The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

17. Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: Development of recommendations for clinical practice based on data from the literature and experts opinion

18. Diagnosis of peripheral psoriatic arthritis: recommendations for clinical practice based on data from the literature and experts opinion

19. Bone scintigraphy pattern of joint chronic graft-versus-host disease after allogeneic bone marrow transplantation

20. The Inactivation Principle: Mathematical Solutions Minimizing the Absolute Work and Biological Implications for the Planning of Arm Movements

21. Pathophysiological links between rheumatoid arthritis and the Epstein-Barr virus: an update

22. Inflammatory and structural evaluation in spondyloarthritis: magnetic resonance imaging analysis of axial and peripheral involvement

23. A support method for the contextual interpretation of biomechanical data

24. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA‐DR shared epitope and severity of bone destruction

25. Motor compensation and recovery for reaching in stroke patients

26. Hand orientation for grasping and arm joint rotation patterns in healthy subjects and hemiparetic stroke patients

27. Positive proprioceptive feedback elicited by isometric contractions of ankle flexors on pretibial motoneurons in cats

28. Development of a disease activity index for the assessment of reactive arthritis (DAREA)

29. Contribution of ankle, knee, and hip joints to the perception threshold for support surface rotation

30. Control of single-joint movements in deafferented patients: evidence for amplitude coding rather than position control

31. High-resolution magnetic resonance imaging of knee inflammatory arthritis in mice

Catalog

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

31 results on '"MESH: Joints"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources