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Your search keyword '"MESH: Macula Lutea"' showing total 2 results
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2 results on '"MESH: Macula Lutea"'

1. Macular Fold Complicating a Subretinal Injection of Voretigene Neparvovec

Author

Michel Weber, Fanny Billaud, Pierre Lebranchu, Jean-Baptiste Ducloyer, Guylène Le Meur, Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, and Nantes Université (Nantes Univ)

Subjects
Male, medicine.medical_specialty, genetic structures, Visual Acuity, MESH: Visual Acuity, Retina, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Retinal Diseases, Ophthalmology, medicine, MESH: Macula Lutea, Humans, Macula Lutea, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, ComputingMilieux_MISCELLANEOUS, MESH: Retinal Diseases, 030304 developmental biology, MESH: Genetic Therapy, 0303 health sciences, MESH: Humans, business.industry, MESH: Retina, Genetic Therapy, MESH: Injections, Intraocular, Leber congenital amaurosis, MESH: Male, eye diseases, MESH: Young Adult, 030221 ophthalmology & optometry, MESH: Retinitis Pigmentosa, sense organs, Injections, Intraocular, business, Retinitis Pigmentosa
Abstract

Synopsis We report the occurrence and the management of a macular fold complicating a subretinal injection of Voretigene Neparvovec for Leber congenital amaurosis associated with bi-allelic mutations of the RPE 65 gene.

Published
2020
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2. Glial cells of the human fovea

Author

Delaunay, Kimberley, Khamsy, Lilly, Kowalczuk, Laura, Gelize, Emmanuelle, Moulin, Alexandre, Nicolas, Michael, Zografos, Leonidas, Lassiaz, Patricia, Behar-Cohen, Francine, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université de Lausanne (UNIL), Fondation Asile des aveugles - Hôpital Ophtalmique Jules-Gonin [Lausanne], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), HAL-SU, Gestionnaire, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), and Université de Lausanne = University of Lausanne (UNIL)

Subjects
Male, Fovea Centralis, genetic structures, Ependymoglial Cells, MESH: Carrier Proteins, Glutamate-Ammonia Ligase, Glial Fibrillary Acidic Protein, Humans, Vimentin, MESH: Macula Lutea, MESH: Glial Fibrillary Acidic Protein, MESH: Glutamate-Ammonia Ligase, Macula Lutea, MESH: Fovea Centralis, Aged, MESH: Aged, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Middle Aged, MESH: Humans, MESH: Immunohistochemistry, Middle Aged, MESH: Ependymoglial Cells, Immunohistochemistry, eye diseases, MESH: Male, MESH: Connexin 43, MESH: Astrocytes, Astrocytes, Connexin 43, Female, MESH: Neuroglia, MESH: Vimentin, sense organs, Carrier Proteins, Neuroglia, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

International audience; PurposeThe exact cellular types that form the human fovea remain a subject of debate, and few studies have been conducted on human macula to solve this question. The purpose of this study was to perform immunohistochemistry on fresh human samples to characterize the glial cells that form the human fovea.MethodsImmunohistochemistry was performed using antibodies against proteins expressed in astrocytes or in retinal Müller glial cells or both types of cells on six human macula obtained from eyes enucleated for peripheral intraocular tumors and on two postmortem eyes from healthy donors. The posterior poles of the enucleated eyes were cryosectioned and stained with antibodies against the glial proteins GFAP, vimentin, CRALBP, glutamine synthetase, and connexin 43.ResultsA population of cells positive for GFAP and negative for glutamine synthetase and CRALBP that express connexin 43 were identified at the roof of the foveal pit. These cells are distinct from the Müller cone cells described by Yamada and Gass, suggesting that another type of foveal glial cells, most likely astrocytes, are present in the human fovea.ConclusionsThis study showed that in humans, astrocytic glial cells cover the foveal pit. Their roles in macula homeostasis and mechanisms of macular disease remain to be determined.

Published
2020

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