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3 results on '"MESH: Maternal Deprivation"'

1. Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner

Author

Julien Chevalier, Jean Christophe Helbling, Patricia Lepage, Élodie Lévy, Pierre-Antoine Grohard, Marion Leboyer, Lilian Basso, Marion Rincel, Gérard Eberl, Muriel Darnaudéry, Hélène Boudin, Camille Monchaux de Oliveira, Sophie Layé, Nathalie Vergnolle, Michel Neunlist, Philippe Aubert, Lucile Capuron, Grégoire Chevalier, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Microenvironnement et Immunité - Microenvironment and Immunity, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Est Créteil, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, University of Bordeaux, INRA, AVIESAN Immunology, Hematology and Pneumology, French Ministry of Research, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, The Enteric Nervous System in gut and brain disorders [U1235] (TENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0301 basic medicine, Lipopolysaccharides, Male, MESH: Maternal Deprivation, Physiology, Gut flora, Anxiety, MESH: Animals, Newborn, Marble burying, Behavioral Neuroscience, Mice, 0302 clinical medicine, MESH: Behavior, Animal, MESH: Animals, Mice, Inbred C3H, biology, Behavior, Animal, Maternal Deprivation, Microbiota, Brain, MESH: Stress, Psychological, Compulsive behavior, Female, medicine.symptom, Gut-brain axis, Emotional behavior, MESH: Social Behavior, Elevated plus maze, Offspring, Immunology, Gut–brain axis, Prefrontal Cortex, Intestinal permeability, MESH: Gastrointestinal Microbiome, 03 medical and health sciences, MESH: Brain, Sex Factors, MESH: Sex Factors, medicine, MESH: Microbiota, Animals, Early-life stress, MESH: Mice, Inbred C3H, Social Behavior, MESH: Mice, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, MESH: Anxiety, Endocrine and Autonomic Systems, HPA axis, [SCCO.NEUR]Cognitive science/Neuroscience, Lachnospiraceae, Ultrasonic vocalizations, biology.organism_classification, medicine.disease, Medial prefrontal cortex, MESH: Male, Gastrointestinal Microbiome, 030104 developmental biology, MESH: Dysbiosis, Animals, Newborn, Dysbiosis, MESH: Prefrontal Cortex, MESH: Female, 030217 neurology & neurosurgery, Stress, Psychological
Abstract

International audience; The accumulation of adverse events in utero and during childhood differentially increases the vulnerability to psychiatric diseases in men and women. Gut microbiota is highly sensitive to the early environment and has been recently hypothesized to affect brain development. However, the impact of early-life adversity on gut microbiota, notably with regards to sex differences, remains to be explored. We examined the effects of multifactorial early-life adversity on behavior and microbiota composition in C3H/HeN mice of both sexes exposed to a combination of maternal immune activation (lipopolysaccharide injection on embryonic day 17, 120 μg/kg, i.p.), maternal separation (3hr per day from postnatal day (PND)2 to PND14) and maternal unpredictable chronic mild stress. At adulthood, offspring exposed to multi-hit early adversity showed sex-specific behavioral phenotypes with males exhibiting deficits in social behavior and females showing increased anxiety in the elevated plus maze and increased compulsive behavior in the marble burying test. Early adversity also differentially regulated gene expression in the medial prefrontal cortex (mPFC) according to sex. Interestingly, several genes such as Arc, Btg2, Fosb, Egr4 or Klf2 were oppositely regulated by early adversity in males versus females. Finally, 16S-based microbiota profiling revealed sex-dependent gut dysbiosis. In males, abundance of taxa belonging to Lachnospiraceae and Porphyromonadaceae families or other unclassified Firmicutes, but also Bacteroides, Lactobacillus and Alloprevotella genera was regulated by early adversity. In females, the effects of early adversity were limited and mainly restricted to Lactobacillus and Mucispirillum genera. Our work reveals marked sex differences in a multifactorial model of early-life adversity, both on emotional behaviors and gut microbiota, suggesting that sex should systematically be considered in preclinical studies both in neurogastroenterology and psychiatric research.

Published
2018
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2. Early and later adoptions differently modify mother-pup interactions

Author

Arnaud Barbazanges, Simona Cabib, Stefania Maccari, Muriel Koehl, Muriel Darnaudéry, Michel Le Moal, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), stress périnatal et maladies neurodégénératives, Université de Lille, Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), and Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, Time Factors, MESH: Maternal Deprivation, MESH: Rats, Sprague-Dawley, MESH: Ultrasonics, MESH: Adoption, MESH: Animals, Newborn, Developmental psychology, Rats, Sprague-Dawley, Behavioral Neuroscience, 0302 clinical medicine, MESH: Pregnancy, Pregnancy, MESH: Behavior, Animal, MESH: Animals, Ultrasonics, Maternal Behavior, Maternal deprivation, Behavior, Animal, Maternal Deprivation, 05 social sciences, Life events, Age Factors, Prenatal development, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, MESH: Rats, Offspring, MESH: Vocalization, Animal, Biology, Affect (psychology), 03 medical and health sciences, Adoption, medicine, Animals, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, MESH: Age Factors, MESH: Time Factors, medicine.disease, MESH: Male, Rats, Prenatal stress, Animals, Newborn, MESH: Maternal Behavior, Vocalization, Animal, Perinatal period, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; Life events occurring during the perinatal period have strong long-term effects. In rats, prenatal stress, postnatal maternal separations, or adoptions at different periods are known to affect behavior and reactivity to stress in offspring. To determine the role of maternal factors on differential outcome adoptions, the authors investigated interactions between pups and the adopting mothers by assessing both pups' ultrasound emissions and maternal behavior. Early and late adoptions increased mother care at the moment of adoption and during mother-infant reunion after a separation procedure. However, although early adoption induced a decrease in pups' ultrasound emissions in response to a stressful separation, later adoptions enhanced it. Results suggest a sensitive period during which fostering may change pups' and dams' behavior.

Published
2004
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3. Adult outcome of children reared for long-term periods in foster families

Author

Marthe Coppel-Batsch, Annick-Camille Dumaret, Simone Couraud, CERMES - Centre de recherche Médecine, Science, Santé Société (CERMES - UMR 8169 / U750), Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fondation Grancher, and Dumaret, Annick Camille

Subjects
Child abuse, Male, MESH: Chi-Square Distribution, MESH: Maternal Deprivation, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Poison control, MESH: Regression Analysis, Foster Home Care, foster care, MESH: Health Surveys, 0302 clinical medicine, Social integration, Child of Impaired Parents, MESH: Risk Factors, Risk Factors, MESH: Child, Developmental and Educational Psychology, MESH: Foster Home Care, Child Abuse, Prospective Studies, Young adult, 10. No inequality, Child, MESH: Treatment Outcome, Family Characteristics, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, 4. Education, Maternal Deprivation, Mental Disorders, 05 social sciences, Age Factors, social integration, follow-up study, MESH: Follow-Up Studies, MESH: Interpersonal Relations, Psychiatry and Mental health, Treatment Outcome, Regression Analysis, Female, France, Psychology, Social Adjustment, MESH: Child Welfare, 050104 developmental & child psychology, Adult, medicine.medical_specialty, Adolescent, MESH: Paternal Deprivation, MESH: Child of Impaired Parents, Child Welfare, 03 medical and health sciences, Paternal Deprivation, 030225 pediatrics, Injury prevention, MESH: Family Characteristics, medicine, intergenerational continuities, MESH: Mental Disorders, Humans, 0501 psychology and cognitive sciences, Interpersonal Relations, Psychiatry, Retrospective Studies, MESH: Adolescent, MESH: Age Factors, Family Health, MESH: Humans, Chi-Square Distribution, MESH: Adult, MESH: Retrospective Studies, MESH: Child Abuse, MESH: Social Adjustment, Child development, Health Surveys, MESH: Male, MESH: Prospective Studies, MESH: France, Foster care, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Pediatrics, Perinatology and Child Health, MESH: Family Health, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography, Follow-Up Studies
Abstract

International audience; OBJECTIVE: To study the long term impact of adverse childhood experiences resulting from family breakdowns combined with a stable care environment. Another aim was to determine predictive factors for maladjusted psycho-social integration in adulthood. METHOD: Sixty-three children from severely psychosocially dysfunctioning families selected from among those having been in care in an institutional setting: All had been reared for at least 5 years by foster families, had been out of care for more than 5 years and were at least 23 years old at the time of the survey. Semi-structured interviews were used in a follow-up study to assess adult outcome, essentially in terms of professional status, social, and family relationships. RESULTS: Data was obtained for 94% of the study population (n = 59), 71% via direct interviews (n = 45). The majority had managed to overcome their childhood adversities: 56% were well-integrated socially, 12% had average integration results, 20% were partially integrated and 10% were in situations of failure. These difficulties were linked to multiple family disturbances and repeated traumatic experiences during childhood (p < .05). Multiple regression analyses indicated that these risk factors accounted for 28% of the variance in the social integration score (p < .0001). Severe emotional deprivation over a prolonged period was a contributing factor to clinical disorders. CONCLUSION: At the study period, intergenerational repetition of "child placement" behaviors, significant in the previous generation, had practically disappeared. The results also highlighted the substantial psychotherapeutic and child-rearing assistance provided by the staff of the foster care agency.

Published
1997

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