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Your search keyword '"MESH: Oculomotor Nerve"' showing total 3 results
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3 results on '"MESH: Oculomotor Nerve"'

1. Intracerebral dynamics of saccade generation in the human frontal eye field and supplementary eye field

Author

Philippe Kahane, Jean-Philippe Lachaux, Dominique Hoffmann, Alain Berthoz, Lorella Minotti, Deransart, Colin, Biologie et pathologie digestive, Institut Louis Bugnard-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurosciences cognitives et imagerie cérébrale (NCIC), Centre National de la Recherche Scientifique (CNRS), Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire de Physiologie de la Perception et de l'Action (LPPA), Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), and Collaboration

Subjects
Supplementary eye field, genetic structures, MESH: Frontal Lobe, Electroencephalography, MESH: Signal Processing, Computer-Assisted, 0302 clinical medicine, Oculomotor Nerve, Neural Pathways, Evoked Potentials, MESH: Brain Mapping, Cerebral Cortex, Brain Mapping, 0303 health sciences, Fourier Analysis, medicine.diagnostic_test, MESH: Electric Stimulation, Signal Processing, Computer-Assisted, Time resolution, Electrodes, Implanted, Frontal Lobe, MESH: Evoked Potentials, Neurology, Saccade, Visual Perception, MESH: Saccades, Psychology, Cognitive Neuroscience, MESH: Orientation, 03 medical and health sciences, Orientation, MESH: Electroencephalography, Reaction Time, Saccades, medicine, Humans, Dominance, Cerebral, 030304 developmental biology, MESH: Oculomotor Nerve, MESH: Humans, MESH: Visual Perception, MESH: Neural Pathways, Eye movement, MESH: Dominance, Cerebral, Electric Stimulation, Saccadic masking, MESH: Cerebral Cortex, MESH: Reaction Time, Functional imaging, MESH: Epilepsies, Partial, Temporal resolution, MESH: Electrodes, Implanted, Epilepsies, Partial, Neuroscience, 030217 neurology & neurosurgery, MESH: Fourier Analysis
Abstract

International audience; Recent functional imaging and electrical stimulation studies have localized in humans two frontal regions critical for the production of saccadic and anti-saccadic eye movements: the frontal and supplementary eye fields (FEF and SEF, respectively). We investigated the time course of their activations during the generation of pro- and anti-saccades from direct intracranial EEG recordings of three human epileptic patients. We found the preparation and the production of the saccades to be coincident with focal and transient increases of EEG power above 60 Hz. Those were produced in very specific brain sites distributed in the FEF and the SEF (as identified by previous human studies at a coarser time resolution). Furthermore, the spatio-temporal resolution of those recordings turned out to be sufficient to discriminate anatomically between several types of neural responses, determined either by the visual or by the motor components of the saccade tasks, and within this second category of responses, between some associated with the preparation of the saccades and others associated with their execution. Altogether, this study provides the first evidence of high-frequency neural responses in the generation of saccades in humans, and provides a firm basis for other studies detailing further the functional organization of the human oculomotor system at this level of spatial and temporal resolution.

Published
2006
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2. Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro

Author

Erwin Idoux, Michel Muhlethaler, L. E. Moore, Mathieu Beraneck, Mauro Serafin, Pierre-Paul Vidal, Patrice Fort, Nicolas Vibert, Neurobiologie des réseaux sensorimoteurs (NRS (U7060)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Department of Biomedical Engineering [Boston], Boston University [Boston] (BU), Laboratoire de Neurobiologie des Réseaux Sensorimoteurs (LNRS), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5), Boston University [Boston] ( BU ), Laboratoire de Neurobiologie des Réseaux Sensorimoteurs ( LNRS ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 ), Centre de Recherches sur la Cognition et l'Apprentissage ( CeRCA ), Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Centre médical universitaire de Genève (CMU), Département de Physiologie, Genève, Suisse, Centre médical universitaire, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Team Physiopathologie des Réseaux Neuronaux Responsables du Cycle Veille-Sommeil, Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre d'étude de la SensoriMotricité (CESEM - UMR 8194), Université Paris Descartes - Paris 5 (UPD5)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Equipe Pharmacognosie (UMR 8638), Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (COMETE - UMR 8638), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Team Physiopathologie des Réseaux Neuronaux Responsables du Cycle Veille-Sommeil (INSERM U1028 - CNRS UMR 5292 - UNIV Lyon 1), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie des réseaux sensorimoteurs ( NRS (U7060) ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), and Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Action Potentials/physiology, Periodicity, MESH: Periodicity, MESH : Electric Stimulation, Physiology, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Membrane Potentials/ physiology, Medial vestibular nucleus, Action Potentials, MESH : Neurons, Afferent, Membrane Potentials, Nucleus prepositus, 0302 clinical medicine, Oculomotor Nerve, MESH : Membrane Potentials, MESH : Female, MESH: Animals, MESH: Models, Theoretical, ComputingMilieux_MISCELLANEOUS, MESH: Action Potentials, Motor Neurons, Membrane potential, Vestibular system, Medulla Oblongata, 0303 health sciences, education.field_of_study, Chemistry, MESH: Neurons, Afferent, General Neuroscience, MESH: Electric Stimulation, MESH : Medulla Oblongata, medicine.anatomical_structure, Membrane, MESH : Periodicity, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, MESH: Vestibular Nuclei, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, MESH : Guinea Pigs, MESH: Motor Neurons, Oculomotor Nerve/ physiology, MESH : Motor Neurons, MESH : Oculomotor Nerve, MESH : Male, Guinea Pigs, Models, Neurological, Population, Medulla Oblongata/ physiology, Sensory system, MESH: Guinea Pigs, 03 medical and health sciences, MESH : Action Potentials, MESH: Models, Neurological, MESH: Medulla Oblongata, Neurons, Afferent/ physiology, medicine, MESH : Models, Neurological, Animals, MESH: Membrane Potentials, Neurons, Afferent, education, 030304 developmental biology, MESH: Oculomotor Nerve, Vestibular Nuclei/physiology, MESH : Models, Theoretical, Vestibular Nuclei, Models, Theoretical, Electric Stimulation, MESH: Male, ddc:616.8, Motor Neurons/physiology, MESH : Animals, MESH : Vestibular Nuclei, MESH: Female, Neuroscience, Nucleus, 030217 neurology & neurosurgery
Abstract

Numerous models of the oculomotor neuronal integrator located in the prepositus hypoglossi nucleus (PHN) involve both highly tuned recurrent networks and intrinsic neuronal properties; however, there is little experimental evidence for the relative role of these two mechanisms. The experiments reported here show that all PHN neurons (PHNn) show marked phasic behavior, which is highly oscillatory in ∼25% of the population. The behavior of this subset of PHNn, referred to as type D PHNn, is clearly different from that of the medial vestibular nucleus neurons, which transmit the bulk of head velocity-related sensory vestibular inputs without integrating them. We have investigated the firing and biophysical properties of PHNn and developed data-based realistic neuronal models to quantitatively illustrate that their active conductances can produce the oscillatory behavior. Although some individual type D PHNn are able to show some features of mathematical integration, the lack of robustness of this behavior strongly suggests that additional network interactions, likely involving all types of PHNn, are essential for the neuronal integrator. Furthermore, the relationship between the impulse activity and membrane potential of type D PHNn is highly nonlinear and frequency-dependent, even for relatively small-amplitude responses. These results suggest that some of the synaptic input to type D PHNn is likely to evoke oscillatory responses that will be nonlinearly amplified as the spike discharge rate increases. It would appear that the PHNn have specific intrinsic properties that, in conjunction with network interconnections, enhance the persistent neural activity needed for their function.

Published
2006
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3. The neural basis of egocentric and allocentric coding of space in humans: a functional magnetic resonance study

Author

E. Lobel, Gaspare Galati, Alain Berthoz, Giuseppe Vallar, Luigi Pizzamiglio, Denis Le Bihan, Galati, G, Lobel, E, Vallar, G, Berthoz, A, Pizzamiglio, L, Le Bihan, D, Geometry and Probability for Motion and Action (E-MOTION), Laboratoire d'informatique GRAphique, VIsion et Robotique de Grenoble (GRAVIR - IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de Physiologie de la Perception et de l'Action (LPPA), Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Inria Grenoble - Rhône-Alpes, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Male, genetic structures, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Frontal Lobe, spatial reference frame, Functional Laterality, MESH: Magnetic Resonance Imaging, 0302 clinical medicine, Oculomotor Nerve, Parietal Lobe, MESH: Parietal Lobe, right hemisphere, medicine.diagnostic_test, General Neuroscience, 05 social sciences, Neuropsychology, Human brain, Magnetic Resonance Imaging, Frontal Lobe, MESH: Photic Stimulation, medicine.anatomical_structure, Female, Psychology, object-based, hemineglect, mid-sagittal plane, object based, spatial, spatial reference frames, Reference frame, Adult, MESH: Space Perception, MESH: Psychomotor Performance, Stimulus (physiology), M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, 050105 experimental psychology, Lateralization of brain function, Perceptual Disorders, 03 medical and health sciences, medicine, Humans, 0501 psychology and cognitive sciences, MESH: Functional Laterality, MESH: Perceptual Disorders, MESH: Oculomotor Nerve, MESH: Humans, MESH: Adult, Magnetic resonance imaging, Neurophysiology, MESH: Male, Space Perception, Functional magnetic resonance imaging, MESH: Female, Neuroscience, Photic Stimulation, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract

International audience; The spatial location of an object can be represented in the brain with respect to different classes of reference frames, either relative to or independent of the subject's position. We used functional magnetic resonance imaging to identify regions of the healthy human brain subserving mainly egocentric or allocentric (object-based) coordinates by asking subjects to judge the location of a visual stimulus with respect to either their body or an object. A color-judgement task, matched for stimuli, difficulty, motor and oculomotor responses, was used as a control. We identified a bilateral, though mainly right-hemisphere based, fronto-parietal network involved in egocentric processing. A subset of these regions, including a much less extensive unilateral, right fronto-parietal network, was found to be active during object-based processing. The right-hemisphere lateralization and the partial superposition of the egocentric and the object-based networks is discussed in the light of neuropsychological findings in brain-damaged patients with unilateral spatial neglect and of neurophysiological studies in the monkey.

Published
2000
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