1. Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis
- Author
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Guillaume Odin, Elodie Basc, Florence Pedeutour, Elodie Long, Basile Pasquier, Véronique Hofman, Paul Hofman, Maxime Benchetritt, Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Otorhinolaryngology, Laboratory of Solid Tumors Genetics, Nice University Hospital, Department of Pathology, Hôpital Michallon, Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Human Tissue Biobank Unit, and Hôpital Pasteur [Nice] (CHU)
- Subjects
Male ,MESH: Combined Modality Therapy ,MESH: Fatal Outcome ,Pathology ,Chromosomes, Human, Pair 22 ,Vimentin ,MESH: Meningioma ,Metastasis ,Fatal Outcome ,Monosomy ,MESH: Aged, 80 and over ,0302 clinical medicine ,Meningeal Neoplasms ,MESH: Orbital Neoplasms ,MESH: Chromosomes, Human, Pair 22 ,Aged, 80 and over ,biology ,General Medicine ,Combined Modality Therapy ,Immunohistochemistry ,MESH: Monosomy ,3. Good health ,MESH: Spectral Karyotyping ,030220 oncology & carcinogenesis ,Cytogenetic Analysis ,Clear cell carcinoma ,Meningioma ,medicine.medical_specialty ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Adenocarcinoma ,Pathology and Forensic Medicine ,Metastatic carcinoma ,Diagnosis, Differential ,03 medical and health sciences ,MESH: Diagnosis, Differential ,Biomarkers, Tumor ,medicine ,Carcinoma ,Clear Cell Meningioma ,Humans ,Molecular Biology ,MESH: Humans ,MESH: Cytogenetic Analysis ,Spectral Karyotyping ,MESH: Adenocarcinoma ,MESH: Immunohistochemistry ,Cell Biology ,MESH: Meningeal Neoplasms ,medicine.disease ,MESH: Male ,[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,MESH: Tumor Markers, Biological ,biology.protein ,Orbital Neoplasms ,030217 neurology & neurosurgery ,Clear cell - Abstract
Clear cell meningiomas (CCM) are rare tumors of the nervous system that usually occur in young patients and display high recurrence rates and potentially aggressive behavior. In this report, we describe a primary CCM of the orbit in an 84-year-old man with a previous history of a clear cell carcinoma of the kidney. Histologically, the tumor demonstrated a sheet-like proliferation of clear polygonal cells. Differential diagnosis includes metastasis of clear cell carcinomas. Immunohistochemistry, by showing that tumor cells expressed vimentin, epithelial membrane antigen, and progesterone antigens, and cytogenetic analysis, by identifying a monosomy 22, confirmed the diagnosis of CCM.
- Published
- 2008
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