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9 results on '"MESH: Thoracic Vertebrae"'

1. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect

Author

C. Chalfouh, Xiaofei Li, C. Guillou, P. Cosette, Q. Delarue, N. Guérout, Jean-Paul Marie, C. Duclos, J. Hardouin, D. Schapman, Delarue, Quentin, Groupe de Recherche sur le Handicap Ventilatoire (GRHV), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Plate-forme de Protéomique PISSARO, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet [Stockholm], Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Lebon, Alexis

Subjects
Male, MESH: Nerve Regeneration, [SDV]Life Sciences [q-bio], Magnetic Field Therapy, Stimulation, Mice, Fibrosis, MESH: Thoracic Vertebrae, Medicine, MESH: Animals, Pharmacology (medical), Spinal cord injury, Cells, Cultured, Spinal Cord Stimulation, Rehabilitation, Age Factors, [SDV] Life Sciences [q-bio], magnetic stimulation and neuroregeneration, medicine.anatomical_structure, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Original Article, glial scar, medicine.symptom, Stem cell, MESH: Cells, Cultured, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Mice, Transgenic, MESH: Spinal Cord Stimulation, Inflammation, Mice, Transgenic, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Thoracic Vertebrae, Glial scar, Lesion, MESH: Mice, Inbred C57BL, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Spinal Cord Injuries, MESH: Magnetic Field Therapy, MESH: Mice, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Spinal Cord Injuries, MESH: Age Factors, Pharmacology, business.industry, medicine.disease, Spinal cord, MESH: Male, spinal cord injury, Nerve Regeneration, Mice, Inbred C57BL, Neurology (clinical), business, MESH: Female, Neuroscience
Abstract

Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is no therapeutic intervention offering a complete recovery. Here, we report that repetitive trans-spinal magnetic stimulation (rTSMS) can be a noninvasive SCI treatment that enhances tissue repair and functional recovery. Several techniques including immunohistochemical, behavioral, cells cultures, and proteomics have been performed. Moreover, different lesion paradigms, such as acute and chronic phase following SCI in wild-type and transgenic animals at different ages (juvenile, adult, and aged), have been used. We demonstrate that rTSMS modulates the lesion scar by decreasing fibrosis and inflammation and increases proliferation of spinal cord stem cells. Our results demonstrate also that rTSMS decreases demyelination, which contributes to axonal regrowth, neuronal survival, and locomotor recovery after SCI. This research provides evidence that rTSMS induces therapeutic effects in a preclinical rodent model and suggests possible translation to clinical application in humans. Electronic supplementary material The online version of this article (10.1007/s13311-020-00915-5) contains supplementary material, which is available to authorized users.

Published
2020
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2. A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review

Author

Jacques Griffet, Loic Sigwalt, C. Durand, Aurélien Courvoisier, E. Bourgeois, Ahmad Eid, Clinique universitaire de chirurgie orthopédique et de traumatologie du sport, hôpital Sud, CHU de Grenoble, avenue de Kimberley, 38130 Échirolles, France, parent, Service de chirurgie pédiatrique [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
medicine.medical_specialty, Pathology, Adolescent, MESH: Giant Cell Tumor of Bone, [SDV]Life Sciences [q-bio], Scoliosis, Thoracic Vertebrae, MESH: Magnetic Resonance Imaging, Malignant transformation, Lesion, 03 medical and health sciences, 0302 clinical medicine, MESH: Thoracic Vertebrae, medicine, Humans, Giant Cell Tumors, Children, MESH: Treatment Outcome, Giant Cell Tumor of Bone, MESH: Adolescent, 030222 orthopedics, Spinal Neoplasms, MESH: Humans, medicine.diagnostic_test, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, MESH: Spinal Neoplasms, General Medicine, medicine.disease, Magnetic Resonance Imaging, Spine, 3. Good health, Treatment Outcome, Primary bone, Bone scintigraphy, Giant cell, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, Giant cell tumor, Neurology (clinical), Neurosurgery, Radiology, medicine.symptom, Tomography, X-Ray Computed, MESH: Tomography, X-Ray Computed, business, MESH: Female
Abstract

Giant cell tumors (GCT) are benign primary bone tumors, locally aggressive, affecting in long bones in young adults during the third decade. It is rare to experience this lesion in skeletally immature patients. GCT are related to a risk of local recurrence and malignant transformation. We report a rare case of a giant cell tumor of the thoracic spine in a skeletally immature girl presenting with a painful right scoliosis. MRI, CT scan, and bone scintigraphy were discordant and the percutaneous biopsy non-contributive. A marginal “en bloc” resection was performed and revealed the GCT. Based on a literature review, the diagnosis and the surgical management of this case are discussed.

Published
2016
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3. Early outcomes of spinal growth tethering for idiopathic scoliosis with a novel device: a prospective study with 2 years of follow-up

Author

Aurélien Courvoisier, Mehdi Boudissa, Jacques Griffet, E. Bourgeois, Ahmad Eid, Service de chirurgie pédiatrique [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
Male, medicine.medical_specialty, Novel device, Vertebral body stapling, [SDV]Life Sciences [q-bio], MESH: Prostheses and Implants, Spinal ligamentoplasty, Idiopathic scoliosis, Thoracic Vertebrae, Adolescent idiopathic scoliosis, Spinal growth tethering, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, MESH: Child, Spine deformity, MESH: Thoracic Vertebrae, Deformity, medicine, Humans, Prospective Studies, Prospective cohort study, Child, MESH: Cohort Studies, MESH: Treatment Outcome, 030222 orthopedics, MESH: Humans, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, MESH: Scoliosis, General Medicine, Growth spurt, Prostheses and Implants, MESH: Follow-Up Studies, MESH: Male, MESH: Prospective Studies, Surgery, Treatment Outcome, Scoliosis, Pediatrics, Perinatology and Child Health, Physical therapy, Female, Neurology (clinical), Neurosurgery, medicine.symptom, business, MESH: Female, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Adolescent idiopathic scoliosis is a 3D spine deformity that worsens during the whole growth. New methods for spinal growth modulation with flexible spinal implants have been described to avoid progression of the deformity during growth spurt. The main limitations are that no specific ancillaries and devices are available, which makes the surgery technically demanding.We have developed a new method of spinal growth tethering using minimal invasive videothoracoscopic approach. Fixation is performed with staples and synthetic ligament on the lateral aspect of vertebral bodies on main curvature convexity. Patients with progressive thoracic idiopathic scoliosis despite the brace treatment were included. The clinical and radiological examinations were compared before and 2 years after surgery.Six patients with flexible thoracic curves with a mean age 11.2 ± 1.2 years and a mean Cobb angle 45° ± 10° (35-60) were operated. All were skeletally immature. At last follow-up, the Cobb angle was stable. None of the patient underwent fusion.The procedure allowed a stabilization of the deformity during growth spurt. Validated devices and further studies with longer term follow-up are needed to confirm the efficiency of this technique. This small cohort of patients is a source of reflection for further medical devices developments.Level 4 case series comparing to not randomized studies.

Published
2017
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4. Posterior Spinal Instrumented Fusion for Idiopathic Scoliosis in Patients with Multisystemic Neurodegenerative Disorder: A Report of Two Cases

Author

Kwong Weng Loh, Chris Yin Wei Chan, Mohd Shahnaz Hasan, Mun Keong Kwan, Chee Kidd Chiu, Krankenanstalt Rudolfstiftung, Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), and Université de Tunis El Manar (UTM)

Subjects
Male, medicine.medical_specialty, Letter to the editor, Mitochondrial disease, medicine.medical_treatment, Encephalopathy, education, MESH: Scoliosis, Idiopathic scoliosis, Scoliosis, 030204 cardiovascular system & hematology, MELAS syndrome, MESH: Neurodegenerative Diseases, 03 medical and health sciences, 0302 clinical medicine, Mitochondrial myopathy, lcsh:Orthopedic surgery, 030202 anesthesiology, MESH: Thoracic Vertebrae, MELAS Syndrome, MESH: Spinal Fusion, medicine, Humans, In patient, Stroke, MESH: Treatment Outcome, 030222 orthopedics, MESH: Humans, business.industry, Siblings, Instrumented fusion, Neurodegenerative Diseases, MESH: Retrospective Studies, medicine.disease, Surgery, lcsh:RD701-811, Spinal Fusion, Anesthesia, Lactic acidosis, Spinal fusion, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS) syndrome is a progressive multisystemic neurodegenerative disorder. MELAS syndrome impairs oxidative phosphorylation and predisposes patients to lactic acidosis, particularly under metabolic stress. We report 2 siblings with MELAS-associated idiopathic scoliosis who underwent posterior spinal instrumented fusion with measures taken to minimise anaesthetic and surgical stress, blood loss, and operating time.

Published
2016
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5. The peripheral nervous system and the perception of verticality

Author

Adolfo M. Bronstein, Sara Tariq, Richard Greenwood, Dominic Pérennou, Michael A. Gresty, G. Mazibrada, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Department of Electrical Engineering, and Tel Aviv University [Tel Aviv]

Subjects
Male, MESH: Proprioception, Poison control, Somatosensory system, MESH: Spinal Injuries, 0302 clinical medicine, MESH: Thoracic Vertebrae, Orthopedics and Sports Medicine, Gravity Sensing, 030223 otorhinolaryngology, media_common, MESH: Aged, MESH: Peripheral Nervous System, Vestibular system, MESH: Middle Aged, Rehabilitation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH: Posture, Sensory loss, Middle Aged, MESH: Case-Control Studies, Peripheral, Female, Adult, medicine.medical_specialty, MESH: Gravity Sensing, media_common.quotation_subject, Posture, Biophysics, Guillain-Barre Syndrome, Thoracic Vertebrae, 03 medical and health sciences, Physical medicine and rehabilitation, Perception, Peripheral Nervous System, Sensation, medicine, Humans, Aged, MESH: Guillain-Barre Syndrome, MESH: Humans, business.industry, MESH: Adult, Proprioception, Trunk, MESH: Male, Surgery, Spinal Injuries, Case-Control Studies, business, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; Orientation of the body with respect to gravity is based on integration of visual, vestibular and somatosensory signals. Here, we investigated the subjective postural vertical (SPV) and visual vertical (SVV) in three patients with bilateral somatosensory deafferentation and a group of age-matched normal subjects. Our hypothesis was that the patients with bilateral somatosensory deafferentation may show tilt induced bias in the construction of their SPV, with a normal SVV. Patient 1 had a severe Guillain Barré syndrome and almost complete absence of peripheral sensation, the two other patients had a thoracic spinal injury with a sensory loss from T6-7 down. On initial testing, compared with normal subjects and the patients with spinal injury, Patient 1 had a significant bias in SPV towards the side of a preceding tilt in both directions. Several months later, after significant improvement of sensation, this tilt-induced bias in SPV had resolved completely. In addition, Patient 1 had a significantly enlarged "cone of verticality", which did not change following improvement in peripheral sensation, reflecting persisting disturbance in the perception of body verticality. In the two patients with spinal injury, bias towards the side of a preceding tilt was not significant. These findings confirm the importance of somatosensory input from the trunk to the perception of SPV in the seated position.

Published
2008
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6. Nouvel arbre décisionnel pour les traumatismes du rachis thoraco-lombaire de l’enfant

Author

Jacques Griffet, C. Durand, E. Bourgeois, Aurélien Courvoisier, Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Centre Hospitalier Universitaire [Grenoble] (CHU)

Subjects
030222 orthopedics, MESH: Decision Trees, MESH: Humans, business.industry, MESH: Spinal Fractures, [SDV]Life Sciences [q-bio], [SCCO.NEUR]Cognitive science/Neuroscience, Anatomy, Lumbar vertebrae, MESH: Magnetic Resonance Imaging, 03 medical and health sciences, MESH: Lumbar Vertebrae, 0302 clinical medicine, medicine.anatomical_structure, 030225 pediatrics, MESH: Child, Pediatrics, Perinatology and Child Health, Thoracic vertebrae, MESH: Thoracic Vertebrae, Medicine, business, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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7. The change on vertebral axial rotation after posterior instrumentation of idiopathic scoliosis

Author

Rémi Kohler, Aurélien Courvoisier, Christophe Garin, Raphaël Vialle, Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Centre Hospitalier Universitaire [Grenoble] (CHU), Service d'Orthopédie et traumatologie Pédiatrique [Hôpital Femme Mère Enfant - HCL], Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
medicine.medical_specialty, Adolescent, Rotation, 3D analysis, [SDV]Life Sciences [q-bio], Idiopathic scoliosis, Scoliosis, Thoracic Vertebrae, MESH: Orthopedic Procedures, Adolescent idiopathic scoliosis, Stereoradiography, MESH: Rotation, MESH: Child, Image Interpretation, Computer-Assisted, MESH: Thoracic Vertebrae, medicine, Humans, Orthopedic Procedures, Instrumentation (computer programming), Child, MESH: Radiography, MESH: Treatment Outcome, Orthodontics, Instrumentation strategy, MESH: Adolescent, MESH: Humans, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, MESH: Scoliosis, General Medicine, medicine.disease, Sagittal plane, Surgery, Radiography, medicine.anatomical_structure, Treatment Outcome, Preoperative planning, Pediatrics, Perinatology and Child Health, Thoracic vertebrae, Posterior instrumentation, Female, Neurology (clinical), business, MESH: Female, MESH: Image Interpretation, Computer-Assisted
Abstract

Agreement between the correction objectives and the instrumentation strategies remains controversial in idiopathic scoliosis. Most studies have focus on the frontal and sagittal plane. The goal of this study was to evaluate the change on vertebral axial rotation after posterior instrumentation in fused and unfused segments.Fourteen patients operated on for idiopathic scoliosis were prospectively included. Fusion and instrumentation were done by posterior approach. All patients had a pre-operative and a 10-day post-operative radiological evaluation with the EOS system. Axial orientation of the vertebrae with special interest to the apical, junctional, and unfused areas was obtained thanks to the reconstruction software.Mean apical vertebra axial rotation statistically decreased from 21° pre-operatively to 13° post-operatively. But, there were no statistically significant differences between pre-operative and post-operative mean axial intervertebral rotations in the main curve and axial rotation of the non-instrumented lower counter curve.3D analysis of the spine in standing position is a great advancement for post-operative analysis of adolescent idiopathic scoliosis (AIS) corrections. This study confirmed that actual instrumentations are able to achieve "en bloc" 3D correction of the spine but not intervertebral axial rotation correction.

Published
2015
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8. Spinal cord compression complicating aseptic spondylodiscitis in ankylosing spondylitis

Author

Toussirot, E., Chataigner, H., Pépin, L., Bertolini, E., Kantelip, B., Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)

Subjects
Male, MESH : Thoracic Vertebrae, Discitis, MESH : Male, MESH: Spinal Cord Compression, MESH : Spondylitis, Ankylosing, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH : Discitis, MESH : Treatment Outcome, Thoracic Vertebrae, MESH: Magnetic Resonance Imaging, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, MESH: Lumbar Vertebrae, MESH : Back Pain, MESH : Magnetic Resonance Imaging, MESH: Thoracic Vertebrae, Humans, Spondylitis, Ankylosing, MESH : Middle Aged, MESH : Lumbar Vertebrae, MESH: Treatment Outcome, MESH: Humans, MESH: Middle Aged, Lumbar Vertebrae, MESH : Humans, Middle Aged, MESH: Spondylitis, Ankylosing, Magnetic Resonance Imaging, MESH: Male, MESH : Spinal Cord Compression, MESH: Discitis, Treatment Outcome, Back Pain, MESH: Back Pain, Spinal Cord Compression
Abstract

International audience; Aseptic spondylodiscitis is a well recognized complication of ankylosing spondylitis. Neurological complications of such discovertebral lesions are uncommon. We report a new case with a diagnosis of T12-L1 spondylodiscitis which developed ten years after a spinal cord compression. Such neurological complications of aseptic spondylodiscitis may be explained by proliferative epidural tissue without predominant inflammatory infiltrates and also the development of new bone reaction, suggesting the contribution of mechanical factors.

Published
2009
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9. Activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat

Author

Samuel Leman, Henrique Sequeira, Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), and Wartel, Anny

Subjects
Male, Stimulation, MESH: Hypertension, MESH: Spinal Cord, MESH: Balloon Dilatation, 0302 clinical medicine, MESH: Thoracic Vertebrae, Adrenal Glands, MESH: Animals, MESH: Adrenal Glands, Spinal cord injury, 0303 health sciences, Adrenal gland, MESH: Proto-Oncogene Proteins c-fos, MESH: Autonomic Fibers, Preganglionic, Immunohistochemistry, Paroxysmal hypertension, medicine.anatomical_structure, Spinal Cord, Hypertension, MESH: Autonomic Dysreflexia, Autonomic dysreflexia, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Proto-Oncogene Proteins c-fos, medicine.medical_specialty, Cholera Toxin, MESH: Rats, Colon, Autonomic Fibers, Preganglionic, Central nervous system, Thoracic Vertebrae, Catheterization, 03 medical and health sciences, Cellular and Molecular Neuroscience, Internal medicine, medicine, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Colon, Rats, Wistar, MESH: Spinal Cord Injuries, MESH: Cholera Toxin, Spinal Cord Injuries, 030304 developmental biology, Endocrine and Autonomic Systems, business.industry, MESH: Chronic Disease, MESH: Immunohistochemistry, MESH: Rats, Wistar, medicine.disease, Spinal cord, MESH: Male, Rats, Endocrinology, Chronic Disease, Autonomic Dysreflexia, Neurology (clinical), Adrenal medulla, business, 030217 neurology & neurosurgery
Abstract

International audience; Autonomic dysreflexia (AD) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. We have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of AD in the 30-day spinal cord-injured (SCI) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to AD. Thus, adrenal sympathetic preganglionic neurons (SPN) could be activated by visceral afferences leading to AD. The aim of this study was then to demonstrate whether visceral stimulation that induces AD activates adrenal SPN in chronic SCI rats. To this end, a retrograde tracer, the cholera toxin B subunit (CTB), was combined with the immunocytochemical detection of Fos protein after visceral stimulation. Chronic SCI rats received a CTB injection into the adrenal gland and, 3 days later, were stimulated by repetitive distension of the colon. Results showed that this stimulation elicited typical hypertensive episodes of AD and a significant increase in the number of double-labeled neurons (CTB/Fos immunoreactive neurons) in the thoracic spinal cord below the level of injury (T4 segment) when compared to the stimulated non-SCI rats. In conclusion, visceral stimulations in the chronic SCI rats activate adrenal SPN, which could induce release of catecholamines by the adrenal medulla. The present study brings new data on the spinal mechanisms of AD cardiovascular dysfunctions.

Published
2002

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